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1. Cytokine production profile of heart-infiltrating T cells in Chagas' disease cardiomyopathy

Author

Cunha-Neto E., Rizzo L.V., Albuquerque F., Abel L., Guilherme L., Bocchi E., Bacal F., Carrara D., Ianni B., Mady C., and Kalil J.

Subjects
Trypanosoma cruzi, Chagas' disease cardiomyopathy, immunology, cytokines, gamma-interferon, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

The hallmark of chronic Chagas' disease cardiomyopathy (CCC) is the finding of a T cell-rich inflammatory mononuclear cell infiltrate in the presence of extremely few parasites in the heart lesions. The scarcity of parasites in affected heart tissue casts doubt on the direct participation of Trypanosoma cruzi in CCC heart tissue lesions, and suggests the possible involvement of autoimmunity. The cells in the infiltrate are presumably the ultimate effectors of tissue damage, and there is evidence that such cells recognize cardiac myosin in molecular mimicry with T. cruzi proteins rather than primary reactivity to T. cruzi antigens (Cunha-Neto et al. (1996) Journal of Clinical Investigation, 98: 1709-1712). Recently, we have studied heart-infiltrating T cells at the functional level. In this short review we summarize the studies about the role of cytokines in human and experimental T. cruzi infection, along with our data on heart-infiltrating T cells in human Chagas' cardiomyopathy. The bulk of evidence points to a significant production of IFN-g and TNF-a which may be linked to T. cruzi-induced IL-12 production

Published
1998

6. Have there been changes in the application of mechanical ventilation in relation to scientific evidence? A multicenter observational study in Mexico

Author

Aguilera Almazán, F., Benítez Cortázar, M., Carrillo Speare, R., Castaño, R., Corral, R., D’Ector Lira, D.N., Díaz Polanco, G., Elizalde, J.J., Envila Fisher, R., Franco, G., García Balbuena, P., Gayoso Cruz, O., Green, L., Herrera Hoyos, J.O., Hinojosa, J., Huerta, J., Juárez, V.A., Loera, M., López Alzate, C., López Mora, E., Martínez Caro, S., Méndez Reyes, R., Mendoza, M., Narváez Porras, O., Ortiz, E., Padua, A., Poblano, M., Pureco Reyes, V., Querevalum, W., Quesada, A., Ramírez Rivera, A., Tamariz, A., Vargas, A., Vázquez, C., Cerda, P., Mercado, R., Albe Castañón, J., Villagómez Ortiz, A.J., Cruz Lozano, C., Maycotte Luna, Z., López Bacal, F., Cueto Robledo, G., Treviño Salinas, M.A., Martínez Zubieta, R., Olvera-Guzmán, C., Montes de Oca, Marco, Ñamendys-Silva, S.A., Martínez Cano, J.S., Baltazar Torres, J.A., Morales Muñoz, G., Villa Delgado, A., Ladape Martínez, J., Ortega Pérez, A., Chávez Morales, A., García Luna, A., Rugiero Cabrera, A., Rugerio Cabrera, A., Pérez-Calatayud, Á.A., Arellano, A., Velasco Gutiérrez, A., Longino Gómez, A.J., Tamariz Becerra Álvarez Calderón, Antonio, Álvarez Calderón Christus Mugerza, R., Reynoso Estrella, C.I., Déctor-Lira Espindola-Cruz, D., Gutiérrez-Zárate, D., Esmeralda, D., Anica Malagón, E.D., Monares Zepeda, E., Deloya, E., Manzo Palacios, E., de Jesús Montelongo, F., Flores Mejía, F.J., Ramírez Cervantes, M., Camarena Alejo, G., Vázquez de Anda, G., Vázquez, H., Larios Luna, C., Zamora, S.E., Magaña Solano, G., Sánchez González, J.I., Rosendo Sánchez Medina, J., Zaragoza, J.J., Buensuseso Alfaro, J.A., Dávila Fernández, J.C., Mijangos-Méndez, J.C., Martínez Medina, M., Chacón Gómez, M., Calyeca Sánchez, M.V., Martínez Soria, J.J., García Graullera, R.J., Rosas, R., Sanjuana Gómez Flores, S., Reyes Inurrigarro, S., Ñamendy-Silva, S.A., Sánchez Hurtado, L.A., Villegas Castellanos, L.L., Zalatiel Maycotte, L., Estrada Gutiérrez, A., León, M.A., Marín, M.C., Elizalde, J., Villagómez, A., Cerón, U., Palma-Lara, I., Sánchez, J.R., Monares, E., Muriel, A., Peñuelas, Ó., Frutos-Vivar, F., and Esteban, A.

Published
2020
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8. Vaccine-Induced Coronay Antibodie-Mediated Rejection and Thrombosis in a Heart Transplant Pacient: A Case Report

Author

Barroso, N.D., primary, Galbiati, L.C., additional, Aragão, C., additional, Fernández, M.P., additional, Avila, M.S., additional, Seguro, L.F., additional, Marcondes-Braga, F.G., additional, Mangini, S., additional, Campos, I.W., additional, de Oliveira Júnior, J., additional, Furquim, S., additional, Pieri, R., additional, Gaiotto, F., additional, and Bacal, F., additional

Published
2022
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9. Multimodality Approach for Surveillance of Cardiac Sarcoidosis After Heart Transplantation Based on a Case Series

Author

Barroso, N.D., primary, Galbiati, L.C., additional, Aragão, C., additional, Fernández, M.P., additional, Furquim, S., additional, Pieri, R., additional, Júnior, J.d., additional, Marcondes-Braga, F.G., additional, Mangini, S., additional, Avila, M.S., additional, Seguro, L., additional, Campos, I.W., additional, Gaiotto, F., additional, and Bacal, F., additional

Published
2022
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10. Challenges in Heart Transplantation During COVID-19 Pandemic in Brazil

Author

Barroso, N.D., primary, Galbiati, L.C., additional, Aragão, C., additional, Avila, M.S., additional, Marcondes-Braga, F.G., additional, Seguro, L., additional, Mangini, S., additional, Campos, I.W., additional, Pieri, R., additional, Furquim, S., additional, Júnior, J.d., additional, Pérez, M., additional, de Paulo, A., additional, Duque, A., additional, Barbosa, M., additional, Ohe, L.A., additional, Gaiotto, F., additional, and Bacal, F., additional

Published
2022
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12. Anatomopathological Consequences of the Change in the Clinical-Demographic Profile of Chagasic Patients Who Are Candidates for Heart Transplantation in Recent Years

Author

Aragao, C.A., primary, Campos, I.W., additional, Duarte, N., additional, Furquim, S., additional, Galbiati, L.C., additional, Perez, M., additional, Pieri, R., additional, Ávila Grinberg, M.S., additional, Seguro, L.F., additional, Marcondes-Braga, F.G., additional, Mangini, S., additional, Strabelli, T.M., additional, Gaiotto, F.A., additional, and Bacal, F., additional

Published
2022
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26. Profile of donor hearts in Brazil: P293

Author

Marcondes-Braga, F G, Mangini, S, Seguro, L FBC, Samuel, M Avila, Melo, J L, Paulo, A R, Sousa, J A, Ohe, L A, Barbosa, M B, and Bacal, F

Published
2014

28. Prevalence of Cognitive Impairment in Heart Transplant Waiting List Patients in a Developing Country

Author

de Oliveira, F.M., primary, Ikeda, E.T., additional, Avila, M.S., additional, Campos, I.W., additional, Seguro, L.F., additional, Santos, M.V., additional, Feltrim, M., additional, Barone, F., additional, Issa, V.S., additional, Lage, S., additional, Bocchi, E.A., additional, Gaiotto, F.A., additional, Nomura, C., additional, Bacal, F., additional, Marcondes-Braga, F.G., additional, and Mangini, S., additional

Published
2021
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29. Incidence and Outcomes of Tuberculosis among Thoracic Organ Transplant Recipients in an Endemic Country - 15 Years of Evaluation

Author

Campos, S.V., primary, Reis, F. Pola Dos, additional, Pires, J.P., additional, Lima, M.L., additional, Abdalla, L.G., additional, Cury, C.B., additional, Fernandes, L.M., additional, Teixeira, R.B., additional, Costa, A.N., additional, Carraro, R.M., additional, Bacal, F., additional, and Pêgo-Fernandes, P.M., additional

Published
2021
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31. Change in the Clinical-Demographic Profile of Chagasic Patients Who are Candidates for Heart Transplantation in Recent Years

Author

Aragao, C.A., primary, Campos, I.W., additional, Lira, M.T., additional, Dantas, R.T., additional, Murad, C.M., additional, Belfort, D.S., additional, Mangini, S., additional, Strabelli, T.V., additional, Braga, F.M., additional, Seguro, L.F., additional, Avila, M.S., additional, Gaiotto, F.A., additional, and Bacal, F., additional

Published
2021
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34. Characteristics and Outcomes of Heart Transplant Recipients with Coronavirus-19 Disease

Author

Marcondes-Braga, F.G., primary, Murad, C.M., additional, Belfort, D. d., additional, Dantas, R.C., additional, Lira, M.S., additional, Aragão, C., additional, Siciliano, R.F., additional, Mangini, S., additional, Seguro, L., additional, de Campos, I.W., additional, Ávila, M.S., additional, Bello, M.V., additional, Barone, F., additional, Strabelli, T.M., additional, Gaiotto, F.A., additional, and Bacal, F., additional

Published
2021
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36. Reccurent Cardiac Myxoma Treated with Cardiac Transplantation: A Case Report

Author

Murad, C.M., primary, Braz, J.C., additional, Mockdece, I.S., additional, Ocampo, V.M., additional, Marcondes-Braga, F.G., additional, Campo, I.W., additional, Steffen, S.P., additional, Seguro, L.B., additional, Mangini, S., additional, Ávila, M.S., additional, Aiello, V.D., additional, Gaiotto, F.A., additional, and Bacal, F., additional

Published
2021
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43. Have there been changes in the application of mechanical ventilation in relation to scientific evidence? A multicenter observational study in Mexico

Author

Marín, M.C., primary, Elizalde, J., additional, Villagómez, A., additional, Cerón, U., additional, Poblano, M., additional, Palma-Lara, I., additional, Sánchez, J.R., additional, Monares, E., additional, Arellano, A., additional, Muriel, A., additional, Peñuelas, Ó., additional, Frutos-Vivar, F., additional, Esteban, A., additional, Aguilera Almazán, F., additional, Benítez Cortázar, M., additional, Carrillo Speare, R., additional, Castaño, R., additional, Corral, R., additional, D’Ector Lira, D.N., additional, Díaz Polanco, G., additional, Elizalde, J.J., additional, Envila Fisher, R., additional, Franco, G., additional, García Balbuena, P., additional, Gayoso Cruz, O., additional, Green, L., additional, Herrera Hoyos, J.O., additional, Hinojosa, J., additional, Huerta, J., additional, Juárez, V.A., additional, Loera, M., additional, López Alzate, C., additional, López Mora, E., additional, Martínez Caro, S., additional, Méndez Reyes, R., additional, Mendoza, M., additional, Narváez Porras, O., additional, Ortiz, E., additional, Padua, A., additional, Pureco Reyes, V., additional, Querevalum, W., additional, Quesada, A., additional, Ramírez Rivera, A., additional, Tamariz, A., additional, Vargas, A., additional, Vázquez, C., additional, Cerda, P., additional, Mercado, R., additional, Albe Castañón, J., additional, Villagómez Ortiz, A.J., additional, Cruz Lozano, C., additional, Maycotte Luna, Z., additional, López Bacal, F., additional, Cueto Robledo, G., additional, Treviño Salinas, M.A., additional, Martínez Zubieta, R., additional, Olvera-Guzmán, C., additional, Montes de Oca, Marco, additional, Ñamendys-Silva, S.A., additional, Martínez Cano, J.S., additional, Baltazar Torres, J.A., additional, Morales Muñoz, G., additional, Villa Delgado, A., additional, Ladape Martínez, J., additional, Ortega Pérez, A., additional, Chávez Morales, A., additional, García Luna, A., additional, Rugiero Cabrera, A., additional, Rugerio Cabrera, A., additional, Pérez-Calatayud, Á.A., additional, Velasco Gutiérrez, A., additional, Longino Gómez, A.J., additional, Tamariz Becerra Álvarez Calderón, Antonio, additional, Álvarez Calderón Christus Mugerza, R., additional, Reynoso Estrella, C.I., additional, Déctor-Lira Espindola-Cruz, D., additional, Gutiérrez-Zárate, D., additional, Esmeralda, D., additional, Anica Malagón, E.D., additional, Monares Zepeda, E., additional, Deloya, E., additional, Manzo Palacios, E., additional, de Jesús Montelongo, F., additional, Flores Mejía, F.J., additional, Ramírez Cervantes, M., additional, Camarena Alejo, G., additional, Vázquez de Anda, G., additional, Vázquez, H., additional, Larios Luna, C., additional, Zamora, S.E., additional, Magaña Solano, G., additional, Sánchez González, J.I., additional, Rosendo Sánchez Medina, J., additional, Zaragoza, J.J., additional, Buensuseso Alfaro, J.A., additional, Dávila Fernández, J.C., additional, Mijangos-Méndez, J.C., additional, Martínez Medina, M., additional, Chacón Gómez, M., additional, Calyeca Sánchez, M.V., additional, Martínez Soria, J.J., additional, García Graullera, R.J., additional, Rosas, R., additional, Sanjuana Gómez Flores, S., additional, Reyes Inurrigarro, S., additional, Ñamendy-Silva, S.A., additional, Sánchez Hurtado, L.A., additional, Villegas Castellanos, L.L., additional, Zalatiel Maycotte, L., additional, Estrada Gutiérrez, A., additional, and León, M.A., additional

Published
2020
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44. ¿Se han producido cambios en la aplicación de la ventilación mecánica en relación con la evidencia científica? Estudio multicéntrico en México

Author

Marín, M.C., primary, Elizalde, J., additional, Villagómez, A., additional, Cerón, U., additional, Poblano, M., additional, Palma-Lara, I., additional, Sánchez, J.R., additional, Monares, E., additional, Arellano, A., additional, Muriel, A., additional, Peñuelas, Ó., additional, Frutos-Vivar, F., additional, Esteban, A., additional, Aguilera Almazán, F., additional, Benítez Cortázar, M., additional, Carrillo Speare, R., additional, Castaño, R., additional, Corral, R., additional, D́Ector Lira, D.N., additional, Díaz Polanco, G., additional, Elizalde, J.J., additional, Envila Fisher, R., additional, Franco, G., additional, García Balbuena, P., additional, Gayoso Cruz, O., additional, Green, L., additional, Herrera Hoyos, J.O., additional, Hinojosa, J., additional, Huerta, J., additional, Juárez, V.A., additional, Loera, M., additional, López Alzate, C., additional, López Mora, E., additional, Martínez Caro, S., additional, Méndez Reyes, R., additional, Mendoza, M., additional, Narváez Porras, O., additional, Ortiz, E., additional, Padua, A., additional, Pureco Reyes, V., additional, Querevalum, W., additional, Quesada, A., additional, Ramírez Rivera, A., additional, Tamariz, A., additional, Vargas, A., additional, Vázquez, C., additional, Cerda, P., additional, Mercado, R., additional, Albe Castañón, J., additional, Villagómez Ortiz, A.J., additional, Cruz Lozano, C., additional, Maycotte Luna, Z., additional, López Bacal, F., additional, Cueto Robledo, G., additional, Treviño Salinas, M.A., additional, Martínez Zubieta, R., additional, Olvera-Guzmán, C., additional, Montes de Oca, Marco, additional, Ñamendys-Silva, S.A., additional, Martínez Cano, J.S., additional, Baltazar Torres, J.A., additional, Morales Muñoz, G., additional, Villa Delgado, A., additional, Ladape Martínez, J., additional, Ortega Pérez, A., additional, Chávez Morales, A., additional, García Luna, A., additional, Rugiero Cabrera, A., additional, Rugerio Cabrera, A., additional, Pérez-Calatayud, Á.A., additional, Velasco Gutiérrez, A., additional, Longino Gómez, A.J., additional, Tamariz Becerra Álvarez Calderón, Antonio, additional, Álvarez Calderón Christus Mugerza, R., additional, Reynoso Estrella, C.I., additional, Déctor-Lira Espindola-Cruz, D., additional, Gutiérrez-Zárate, D., additional, Esmeralda, D., additional, Anica Malagón, E.D., additional, Monares Zepeda, E., additional, Deloya, E., additional, Manzo Palacios, E., additional, de Jesús Montelongo, F., additional, Flores Mejía, F.J., additional, Ramírez Cervantes, M., additional, Camarena Alejo, G., additional, Vázquez de Anda, G., additional, Vázquez, H., additional, Larios Luna, C., additional, Zamora, S.E., additional, Magaña Solano, G., additional, Sánchez González, J.I., additional, Rosendo Sánchez Medina, J., additional, Zaragoza, J.J., additional, Buensuseso Alfaro, J.A., additional, Dávila Fernández, J.C., additional, Mijangos-Méndez, J.C., additional, Martínez Medina, M., additional, Chacón Gómez, M., additional, Calyeca Sánchez, M.V., additional, Martínez Soria, J.J., additional, García Graullera, R.J., additional, Rosas, R., additional, Sanjuana Gómez Flores, S., additional, Reyes Inurrigarro, S., additional, Ñamendy-Silva, S.A., additional, Sánchez Hurtado, L.A., additional, Villegas Castellanos, L.L., additional, Zalatiel Maycotte, L., additional, Estrada Gutiérrez, A., additional, and León, M.A., additional

Published
2020
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47. Prevalence of Cognitive Impairment in Heart Transplant Waiting-List Patients in a Developing Country

Author

de Oliveira, F.M., primary, Ikeda, E.T., additional, Avila, M., additional, Wozniak, I., additional, Seguro, L., additional, Santos, M., additional, Feltrim, M., additional, Barone, F., additional, Issa, V., additional, Lage, S., additional, Bacal, F., additional, Bocchi, E., additional, Gaiotto, F., additional, Nomura, C., additional, Marcondes-Braga, F., additional, and Mangini, S., additional

Published
2020
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50. Effects of serelaxin in patients with acute heart failure

Author

Metra, M., Teerlink, J. R., Cotter, G., Davison, B. A., Felker, G. M., Filippatos, G., Greenberg, B. H., Pang, P. S., Ponikowski, P., Voors, A. A., Adams, K. F., Anker, S. D., Arias-Mendoza, A., Avendano, P., Bacal, F., Bohm, M., Bortman, G., Cleland, J. G. F., Cohen-Solal, A., Crespo-Leiro, M. G., Dorobantu, M., Echeverria, L. E., Ferrari, R., Goland, S., Goncalvesova, E., Goudev, A., Kober, L., Lema-Osores, J., Levy, P. D., Mcdonald, K., Manga, P., Merkely, B., Mueller, C., Pieske, B., Silva-Cardoso, J., Spinar, J., Squire, I., Stepinska, J., Van Mieghem, W., Von Lewinski, D., Wikstrom, G., Yilmaz, M. B., Hagner, N., Holbro, T., Hua, T. A., Sabarwal, S. V., Severin, T., Szecsody, P., Gimpelewicz, C, Lembo, G, and Cardiovascular Centre (CVC)

Subjects
Male, Vasodilator Agents, Vasodilation, Blood Pressure, 030204 cardiovascular system & hematology, NESIRITIDE, THERAPY, law.invention, 0302 clinical medicine, Randomized controlled trial, law, 030212 general & internal medicine, Treatment Failure, Acute Disease, Aged, Cardiovascular Diseases, Disease Progression, Double-Blind Method, Female, Heart Failure, Hospitalization, Humans, Incidence, Infusions, Intravenous, Recombinant Proteins, Relaxin, OUTCOMES, General Medicine, ASSOCIATION, ADMISSION, INSIGHTS, Cardiology, SUBSEQUENT MORTALITY, Intravenous, hormones, hormone substitutes, and hormone antagonists, medicine.drug, medicine.medical_specialty, Infusions, NO, 03 medical and health sciences, Serelaxin, Internal medicine, medicine, In patient, Nesiritide, Pregnancy, business.industry, medicine.disease, PROTECT, Heart failure, RELAX-AHF, business, Hormone
Abstract

BackgroundSerelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in better outcomes in patients with acute heart failure.MethodsIn this multicenter, double-blind, placebo-controlled, event-driven trial, we enrolled patients who were hospitalized for acute heart failure and had dyspnea, vascular congestion on chest radiography, increased plasma concentrations of natriuretic peptides, mild-to-moderate renal insufficiency, and a systolic blood pressure of at least 125 mm Hg, and we randomly assigned them within 16 hours after presentation to receive either a 48-hour intravenous infusion of serelaxin (30 mu g per kilogram of body weight per day) or placebo, in addition to standard care. The two primary end points were death from cardiovascular causes at 180 days and worsening heart failure at 5 days.ResultsA total of 6545 patients were included in the intention-to-treat analysis. At day 180, death from cardiovascular causes had occurred in 285 of the 3274 patients (8.7%) in the serelaxin group and in 290 of the 3271 patients (8.9%) in the placebo group (hazard ratio, 0.98; 95% confidence interval [CI], 0.83 to 1.15; P=0.77). At day 5, worsening heart failure had occurred in 227 patients (6.9%) in the serelaxin group and in 252 (7.7%) in the placebo group (hazard ratio, 0.89; 95% CI, 0.75 to 1.07; P=0.19). There were no significant differences between the groups in the incidence of death from any cause at 180 days, the incidence of death from cardiovascular causes or rehospitalization for heart failure or renal failure at 180 days, or the length of the index hospital stay. The incidence of adverse events was similar in the two groups.ConclusionsIn this trial involving patients who were hospitalized for acute heart failure, an infusion of serelaxin did not result in a lower incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days than placebo. (Funded by Novartis Pharma; RELAX-AHF-2 ClinicalTrials.gov number, NCT01870778.)In a randomized trial, 6545 patients with acute heart failure were assigned to either serelaxin or placebo in addition to standard care. There were no significant differences between the two groups in the incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days.

Published
2019

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