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3,204 results on '"Baccarani, Michele"'

3. INCB84344-201: Ponatinib and steroids in frontline therapy for unfit patients with Ph+ acute lymphoblastic leukemia

Author

Martinelli, Giovanni, Papayannidis, Cristina, Piciocchi, Alfonso, Robustelli, Valentina, Soverini, Simona, Terragna, Carolina, Marconi, Giovanni, Lemoli, Roberto M., Guolo, Fabio, Fornaro, Antonella, Lunghi, Monia, de Fabritiis, Paolo, Candoni, Anna, Selleri, Carmine, Simonetti, Federico, Bocchia, Monica, Vitale, Antonella, Frison, Luca, Tedeschi, Alessandra, Cuneo, Antonio, Bonifacio, Massimiliano, Martelli, Maria Paola, D'Ardia, Stefano, Trappolini, Silvia, Tosi, Patrizia, Galieni, Piero, Fabbiano, Francesco, Abbenante, Maria Chiara, Granier, Muriel, Zhu, Zhaoyin, Wang, Mingyue, Sartor, Chiara, Paolini, Stefania, Cavo, Michele, Foà, Robin, Fazi, Paola, Vignetti, Marco, and Baccarani, Michele

Published
2022
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6. BCR-ABL1 compound mutants: prevalence, spectrum and correlation with tyrosine kinase inhibitor resistance in a consecutive series of Philadelphia chromosome-positive leukemia patients analyzed by NGS

Author

Soverini, Simona, Martelli, Margherita, Bavaro, Luana, De Benedittis, Caterina, Sica, Simona, Sorà, Federica, Iurlo, Alessandra, Bonifacio, Massimiliano, Pregno, Patrizia, Galimberti, Sara, Lunghi, Francesca, Albano, Francesco, D’Adda, Mariella, Crugnola, Monica, Capodanno, Isabella, Castagnetti, Fausto, Gugliotta, Gabriele, Papayannidis, Cristina, Rosti, Gianantonio, Percesepe, Antonio, Mignone, Flavio, Baccarani, Michele, Martinelli, Giovanni, and Cavo, Michele

Published
2021
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7. Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial

Author

Cortes, Jorge E, Saglio, Giuseppe, Kantarjian, Hagop M, Baccarani, Michele, Mayer, Jiří, Boqué, Concepción, Shah, Neil P, Chuah, Charles, Casanova, Luis, Bradley-Garelik, Brigid, Manos, George, and Hochhaus, Andreas

Subjects
Clinical Research, Orphan Drug, Rare Diseases, Hematology, Pediatric, Cancer, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Dasatinib, Fusion Proteins, bcr-abl, Humans, Imatinib Mesylate, Leukemia, Myeloid, Chronic-Phase, Middle Aged, Mutation, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeWe report the 5-year analysis from the phase III Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients (DASISION) trial, evaluating long-term efficacy and safety outcomes of patients with chronic myeloid leukemia (CML) in chronic phase (CP) treated with dasatinib or imatinib.Patients and methodsPatients with newly diagnosed CML-CP were randomly assigned to receive dasatinib 100 mg once daily (n = 259) or imatinib 400 mg once daily (n = 260).ResultsAt the time of study closure, 61% and 63% of dasatinib- and imatinib-treated patients remained on initial therapy, respectively. Cumulative rates of major molecular response and molecular responses with a 4.0- or 4.5-log reduction in BCR-ABL1 transcripts from baseline by 5 years remained statistically significantly higher for dasatinib compared with imatinib. Rates for progression-free and overall survival at 5 years remained high and similar across treatment arms. In patients who achieved BCR-ABL1 ≤ 10% at 3 months (dasatinib, 84%; imatinib, 64%), improvements in progression-free and overall survival and lower rates of transformation to accelerated/blast phase were reported compared with patients with BCR-ABL1 greater than 10% at 3 months. Transformation to accelerated/blast phase occurred in 5% and 7% of patients in the dasatinib and imatinib arms, respectively. Fifteen dasatinib-treated and 19 imatinib-treated patients had BCR-ABL1 mutations identified at discontinuation. There were no new or unexpected adverse events identified in either treatment arm, and pleural effusion was the only drug-related, nonhematologic adverse event reported more frequently with dasatinib (28% v 0.8% with imatinib). First occurrences of pleural effusion were reported with dasatinib, with the highest incidence in year 1. Arterial ischemic events were uncommon in both treatment arms.ConclusionThese final results from the DASISION trial continue to support dasatinib 100 mg once daily as a safe and effective first-line therapy for the long-term treatment of CML-CP.

Published
2016

8. Managing chronic myeloid leukemia for treatment-free remission: a proposal from the GIMEMA CML WP

Author

Baccarani, Michele, Abruzzese, Elisabetta, Accurso, Vincenzo, Albano, Francesco, Annunziata, Mario, Barulli, Sara, Beltrami, Germana, Bergamaschi, Micaela, Binotto, Gianni, Bocchia, Monica, Caocci, Giovanni, Capodanno, Isabella, Cavazzini, Francesco, Cedrone, Michele, Cerrano, Marco, Crugnola, Monica, D'Adda, Mariella, Elena, Chiara, Fava, Carmen, Fazi, Paola, Fozza, Claudio, Galimberti, Sara, Giai, Valentina, Gozzini, Antonella, Gugliotta, Gabriele, Iurlo, Alessandra, La Barba, Gaetano, Levato, Luciano, Lucchesi, Alessandro, Luciano, Luigia, Lunghi, Francesca, Lunghi, Monia, Malagola, Michele, Marasca, Roberto, Martino, Bruno, Melpignano, Angela, Miggiano, Maria Cristina, Montefusco, Enrico, Musolino, Caterina, Palmieri, Fausto, Pregno, Patrizia, Rapezzi, Davide, Rege-Cambrin, Giovanna, Rupoli, Serena, Salvucci, Marzia, Sancetta, Rosaria, Sica, Simona, Spadano, Raffaele, Stagno, Fabio, Tiribelli, Mario, Tomassetti, Simona, Trabacchi, Elena, Bonifacio, Massimiliano, Breccia, Massimo, Castagnetti, Fausto, Pane, Fabrizio, Russo, Domenico, Saglio, Giuseppe, Soverini, Simona, Vigneri, Paolo, and Rosti, Gianantonio

Published
2019
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9. Validation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 Summary Score in Patients With Hematologic Malignancies

Author

Efficace, Fabio, Cottone, Francesco, Sommer, Kathrin, Kieffer, Jacobien, Aaronson, Neil, Fayers, Peter, Groenvold, Mogens, Caocci, Giovanni, Lo Coco, Francesco, Gaidano, Gianluca, Niscola, Pasquale, Baccarani, Michele, Rosti, Gianantonio, Venditti, Adriano, Angelucci, Emanuele, Fazi, Paola, Vignetti, Marco, and Giesinger, Johannes

Published
2019
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10. High-risk additional chromosomal abnormalities at low blast counts herald death by CML

Author

Hehlmann, Rüdiger, Voskanyan, Astghik, Lauseker, Michael, Pfirrmann, Markus, Kalmanti, Lida, Rinaldetti, Sebastien, Kohlbrenner, Katharina, Haferlach, Claudia, Schlegelberger, Brigitte, Fabarius, Alice, Seifarth, Wolfgang, Spieß, Birgit, Wuchter, Patrick, Krause, Stefan, Kolb, Hans-Jochem, Neubauer, Andreas, Hossfeld, Dieter K., Nerl, Christoph, Gratwohl, Alois, Baerlocher, Gabriela M., Burchert, Andreas, Brümmendorf, Tim H., Hasford, Jörg, Hochhaus, Andreas, Saußele, Susanne, and Baccarani, Michele

Published
2020
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11. The EUTOS long-term survival (ELTS) score is superior to the Sokal score for predicting survival in chronic myeloid leukemia

Author

Pfirrmann, Markus, Clark, Richard E., Prejzner, Witold, Lauseker, Michael, Baccarani, Michele, Saussele, Susanne, Guilhot, François, Heibl, Sonja, Hehlmann, Rüdiger, Faber, Edgar, Turkina, Anna, Ossenkoppele, Gert, Höglund, Martin, Zaritskey, Andrey, Griskevicius, Laimonas, Olsson-Strömberg, Ulla, Everaus, Hele, Koskenvesa, Perttu, Labar, Boris, Sacha, Tomasz, Zackova, Daniela, Cervantes, Francisco, Colita, Adriana, Zupan, Irena, Bogdanovic, Andrija, Castagnetti, Fausto, Guilhot, Joëlle, Hasford, Joerg, Hochhaus, Andreas, and Hoffmann, Verena S.

Published
2020
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14. In Ph+BCR-ABL1P210+ acute lymphoblastic leukemia the e13a2 (B2A2) transcript is prevalent

Author

Baccarani, Michele, Iacobucci, Ilaria, Chiaretti, Sabina, Foà’, Robin, Balasubramanian, Poonkuzhali, Paietta, Elisabeth, Foroni, Letizia, Jeromin, Sabine, Izzo, Barbara, Spinelli, Orietta, Varma, Neelam, Menif, Samia, Terragna, Carolina, Seth, Tulika, Bidet, Audrey, Coriu, Daniel, Lunghi, Francesca, Mayer, Jiri, Scappini, Barbara, Langabeer, Stephen, Maier, Jacqueline, Burt, Emma, Candoni, Anna, Albano, Francesco, Luppi, Mario, Zupan, Irena, Lion, Thomas, Zadro, Renata, di Raimondo, Francesco, Poopak, Behzad, Rege-Cambrin, Giovanna, Annunziata, Mario, Ayala, Ana, Salinas-Viedma, Victor, Ines Prado, Ana, Milner, Benedict, Galimberti, Sara, Janssen, Jeroen, Polli, Valentina, Comba, Lorenzo, Borsellino, Beatrice, Annibali, Ombretta, Crugnola, Monica, and Passamonti, Francesco

Published
2020
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15. Ponatinib efficacy and safety in Philadelphia chromosome–positive leukemia: final 5-year results of the phase 2 PACE trial

Author

Cortes, Jorge E., Kim, Dong-Wook, Pinilla-Ibarz, Javier, le Coutre, Philipp D., Paquette, Ronald, Chuah, Charles, Nicolini, Franck E., Apperley, Jane F., Khoury, H. Jean, Talpaz, Moshe, DeAngelo, Daniel J., Abruzzese, Elisabetta, Rea, Delphine, Baccarani, Michele, Müller, Martin C., Gambacorti-Passerini, Carlo, Lustgarten, Stephanie, Rivera, Victor M., Haluska, Frank G., Guilhot, François, Deininger, Michael W., Hochhaus, Andreas, Hughes, Timothy P., Shah, Neil P., and Kantarjian, Hagop M.

Published
2018
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17. Data from c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells

Author

Porro, Antonio, primary, Iraci, Nunzio, primary, Soverini, Simona, primary, Diolaiti, Daniel, primary, Gherardi, Samuele, primary, Terragna, Carolina, primary, Durante, Sandra, primary, Valli, Emanuele, primary, Kalebic, Thea, primary, Bernardoni, Roberto, primary, Perrod, Chiara, primary, Haber, Michelle, primary, Norris, Murray D., primary, Baccarani, Michele, primary, Martinelli, Giovanni, primary, and Perini, Giovanni, primary

Published
2023
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18. Supplementary Figures 1-4, Tables 1-2 from c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells

Author

Porro, Antonio, primary, Iraci, Nunzio, primary, Soverini, Simona, primary, Diolaiti, Daniel, primary, Gherardi, Samuele, primary, Terragna, Carolina, primary, Durante, Sandra, primary, Valli, Emanuele, primary, Kalebic, Thea, primary, Bernardoni, Roberto, primary, Perrod, Chiara, primary, Haber, Michelle, primary, Norris, Murray D., primary, Baccarani, Michele, primary, Martinelli, Giovanni, primary, and Perini, Giovanni, primary

Published
2023
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21. Supplementary Methods, Tables 1-7, Figures 1-4 from CDKN2A/B Alterations Impair Prognosis in Adult BCR-ABL1–Positive Acute Lymphoblastic Leukemia Patients

Author

Iacobucci, Ilaria, primary, Ferrari, Anna, primary, Lonetti, Annalisa, primary, Papayannidis, Cristina, primary, Paoloni, Francesca, primary, Trino, Stefania, primary, Storlazzi, Clelia Tiziana, primary, Ottaviani, Emanuela, primary, Cattina, Federica, primary, Impera, Luciana, primary, Abbenante, Maria Chiara, primary, Vignetti, Marco, primary, Vitale, Antonella, primary, Potenza, Leonardo, primary, Paolini, Stefania, primary, Soverini, Simona, primary, Pane, Fabrizio, primary, Luppi, Mario, primary, Foà, Robin, primary, Baccarani, Michele, primary, and Martinelli, Giovanni, primary

Published
2023
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22. Supplementary Tables 1-5 from Gene Expression Analysis of Angioimmunoblastic Lymphoma Indicates Derivation from T Follicular Helper Cells and Vascular Endothelial Growth Factor Deregulation

Author

Piccaluga, Pier Paolo, primary, Agostinelli, Claudio, primary, Califano, Andrea, primary, Carbone, Antonino, primary, Fantoni, Luca, primary, Ferrari, Sergio, primary, Gazzola, Anna, primary, Gloghini, Annunziata, primary, Righi, Simona, primary, Rossi, Maura, primary, Tagliafico, Enrico, primary, Zinzani, Pier Luigi, primary, Zupo, Simonetta, primary, Baccarani, Michele, primary, and Pileri, Stefano A., primary

Published
2023
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23. Supplementary File 1 from Gene Expression Analysis of Angioimmunoblastic Lymphoma Indicates Derivation from T Follicular Helper Cells and Vascular Endothelial Growth Factor Deregulation

Author

Piccaluga, Pier Paolo, primary, Agostinelli, Claudio, primary, Califano, Andrea, primary, Carbone, Antonino, primary, Fantoni, Luca, primary, Ferrari, Sergio, primary, Gazzola, Anna, primary, Gloghini, Annunziata, primary, Righi, Simona, primary, Rossi, Maura, primary, Tagliafico, Enrico, primary, Zinzani, Pier Luigi, primary, Zupo, Simonetta, primary, Baccarani, Michele, primary, and Pileri, Stefano A., primary

Published
2023
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24. Pleural effusion and molecular response in dasatinib-treated chronic myeloid leukemia patients in a real-life Italian multicenter series

Author

Iurlo, Alessandra, Galimberti, Sara, Abruzzese, Elisabetta, Annunziata, Mario, Bonifacio, Massimiliano, Latagliata, Roberto, Pregno, Patrizia, Ferrero, Dario, Sorà, Federica, Orlandi, Ester Maria, Fava, Carmen, Cattaneo, Daniele, Bucelli, Cristina, Binotto, Gianni, Pungolino, Ester, Tiribelli, Mario, Gozzini, Antonella, Gugliotta, Gabriele, Castagnetti, Fausto, Stagno, Fabio, Rege-Cambrin, Giovanna, Martino, Bruno, Luciano, Luigiana, Breccia, Massimo, Sica, Simona, Bocchia, Monica, Pane, Fabrizio, Saglio, Giuseppe, Rosti, Gianantonio, Specchia, Giorgina, Cortelezzi, Agostino, and Baccarani, Michele

Published
2017
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26. Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial

Author

Lipton, Jeffrey H, Chuah, Charles, Guerci-Bresler, Agnès, Rosti, Gianantonio, Simpson, David, Assouline, Sarit, Etienne, Gabriel, Nicolini, Franck E, le Coutre, Philipp, Clark, Richard E, Stenke, Leif, Andorsky, David, Oehler, Vivian, Lustgarten, Stephanie, Rivera, Victor M, Clackson, Timothy, Haluska, Frank G, Baccarani, Michele, Cortes, Jorge E, Guilhot, François, Hochhaus, Andreas, Hughes, Timothy, Kantarjian, Hagop M, Shah, Neil P, Talpaz, Moshe, and Deininger, Michael W

Published
2016
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27. Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients

Author

Deininger, Michael W., Hodgson, J. Graeme, Shah, Neil P., Cortes, Jorge E., Kim, Dong-Wook, Nicolini, Franck E., Talpaz, Moshe, Baccarani, Michele, Müller, Martin C., Li, Jin, Parker, Wendy T., Lustgarten, Stephanie, Clackson, Tim, Haluska, Frank G., Guilhot, Francois, Kantarjian, Hagop M., Soverini, Simona, Hochhaus, Andreas, Hughes, Timothy P., Rivera, Victor M., and Branford, Susan

Published
2016
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30. Correction: High-risk additional chromosomal abnormalities at low blast counts herald death by CML

Author

Hehlmann, Rüdiger, Voskanyan, Astghik, Lauseker, Michael, Pfirrmann, Markus, Kalmanti, Lida, Rinaldetti, Sebastien, Kohlbrenner, Katharina, Haferlach, Claudia, Schlegelberger, Brigitte, Fabarius, Alice, Seifarth, Wolfgang, Spieß, Birgit, Wuchter, Patrick, Krause, Stefan, Kolb, Hans-Jochem, Neubauer, Andreas, Hossfeld, Dieter K., Nerl, Christoph, Gratwohl, Alois, Baerlocher, Gabriela M., Burchert, Andreas, Brümmendorf, Tim H., Hasford, Jörg, Hochhaus, Andreas, Saußele, Susanne, and Baccarani, Michele

Published
2020
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38. International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: the EORTC QLQ-CML24

Author

Efficace, Fabio, Baccarani, Michele, Breccia, Massimo, Saussele, Susanne, Abel, Gregory, Caocci, Giovanni, Guilhot, Francois, Cocks, Kim, Naeem, Adel, Sprangers, Mirjam, Oerlemans, Simone, Chie, Weichu, Castagnetti, Fausto, Bombaci, Felice, Sharf, Giora, Cardoni, Annarita, Noens, Lucien, Pallua, Stephan, Salvucci, Marzia, Nicolatou-Galitis, Ourania, Rosti, Gianantonio, and Mandelli, Franco

Published
2014

42. Treatment-free remission in chronic myeloid leukemia patients treated front-line with nilotinib: 10-year followup of the GIMEMA CML 0307 study

Author

Gugliotta, Gabriele, primary, Castagnetti, Fausto, additional, Breccia, Massimo, additional, Levato, Luciano, additional, Intermesoli, Tamara, additional, D'Adda, Mariella, additional, Salvucci, Marzia, additional, Stagno, Fabio, additional, Rege-Cambrin, Giovanna, additional, Tiribelli, Mario, additional, Martino, Bruno, additional, Bocchia, Monica, additional, Cedrone, Michele, additional, Trabacchi, Elena, additional, Cavazzini, Francesco, additional, Porretto, Ferdinando, additional, Sorà, Federica, additional, Simula, Maria Pina, additional, Albano, Francesco, additional, Soverini, Simona, additional, Foà, Robin, additional, Pane, Fabrizio, additional, Cavo, Michele, additional, Saglio, Giuseppe, additional, Baccarani, Michele, additional, and Rosti, Gianantonio, additional

Published
2022
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43. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013

Author

Baccarani, Michele, Deininger, Michael W., Rosti, Gianantonio, Hochhaus, Andreas, Soverini, Simona, Apperley, Jane F., Cervantes, Francisco, Clark, Richard E., Cortes, Jorge E., Guilhot, François, Hjorth-Hansen, Henrik, Hughes, Timothy P., Kantarjian, Hagop M., Kim, Dong-Wook, Larson, Richard A., Lipton, Jeffrey H., Mahon, François-Xavier, Martinelli, Giovanni, Mayer, Jiri, Müller, Martin C., Niederwieser, Dietger, Pane, Fabrizio, Radich, Jerald P., Rousselot, Philippe, Saglio, Giuseppe, Saußele, Susanne, Schiffer, Charles, Silver, Richard, Simonsson, Bengt, Steegmann, Juan-Luis, Goldman, John M., and Hehlmann, Rüdiger

Published
2013
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44. Effects and outcome of a policy of intermittent imatinib treatment in elderly patients with chronic myeloid leukemia

Author

Russo, Domenico, Martinelli, Giovanni, Malagola, Michele, Skert, Cristina, Soverini, Simona, Iacobucci, Ilaria, De Vivo, Antonio, Testoni, Nicoletta, Castagnetti, Fausto, Gugliotta, Gabriele, Turri, Diamante, Bergamaschi, Michela, Pregno, Patrizia, Pungolino, Ester, Stagno, Fabio, Breccia, Massimo, Martino, Bruno, Intermesoli, Tamara, Fava, Carmen, Abruzzese, Elisabetta, Tiribelli, Mario, Bigazzi, Catia, Cesana, Bruno Mario, Rosti, Gianantonio, and Baccarani, Michele

Published
2013
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48. A population‐based study of chronic myeloid leukemia patients treated with imatinib in first line

Author

Castagnetti, Fausto, Di Raimondo, Francesco, De Vivo, Antonio, Spitaleri, Antonio, Gugliotta, Gabriele, Fabbiano, Francesco, Capodanno, Isabella, Mannina, Donato, Salvucci, Marzia, Antolino, Agostino, Marasca, Roberto, Musso, Maurizio, Crugnola, Monica, Impera, Stefana, Trabacchi, Elena, Musolino, Caterina, Cavazzini, Francesco, Mineo, Giuseppe, Tosi, Patrizia, Tomaselli, Carmela, Rizzo, Michele, Siragusa, Sergio, Fogli, Miriam, Ragionieri, Riccardo, Zironi, Alessandro, Soverini, Simona, Martinelli, Giovanni, Cavo, Michele, Vigneri, Paolo, Stagno, Fabio, Rosti, Gianantonio, and Baccarani, Michele

Published
2017
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49. Next-generation deep sequencing improves detection of BCR-ABL1 kinase domain mutations emerging under tyrosine kinase inhibitor treatment of chronic myeloid leukemia patients in chronic phase

Author

Machova Polakova, Katerina, Kulvait, Vojtech, Benesova, Adela, Linhartova, Jana, Klamova, Hana, Jaruskova, Monika, de Benedittis, Caterina, Haferlach, Torsten, Baccarani, Michele, Martinelli, Giovanni, Stopka, Tomas, Ernst, Thomas, Hochhaus, Andreas, Kohlmann, Alexander, and Soverini, Simona

Published
2015
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