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1. Risk Score for Long-Term Survival and Major Adverse Cardiovascular and Cerebrovascular Events After Coronary Artery Bypass Grafting Surgery

Author

Dokollari, Aleksander, Rosati, Fabrizio, Muneretto, Claudio, Amabile, Andrea, Pernoci, Marjela, Gemelli, Marco, Hassanabad, Ali Fatehi, Sicouri, Serge, Sicouri, Noah, Yamashita, Yoshiyuki, Baudo, Massimo, Bonacchi, Massimo, Cabrucci, Francesco, Bacchi, Beatrice, Ghorpade, Nitin, Shah, Ashish, Coku, Lindita, Cameli, Matteo, Mandoli, Giulia Elena, Kjelstrom, Stephanie, Montone, Georgia, Wertan, Maryann, Ramlawi, Basel, DiMagli, Arnaldo, and Sutter, Francis P.

Published
2024
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2. Midterm Clinical Outcomes of Robotic-Assisted Reverse Hybrid Coronary Revascularization: A Single-Center Experience

Author

Dokollari, Aleksander, Gemelli, Marco, Sicouri, Serge, Gray, William A., Shapiro, Timothy A., McGeehin, Frank, Badri, Marwan, Coady, Paul, Gnall, Eric, Caroline, Mara, Khan, Amid A., Bonacchi, Massimo, Cabrucci, Francesco, Bacchi, Beatrice, Chiarello, Bruno, Shah, Ashish, Spooner, Aaron, Ghorpade, Nitin, Hassanabad, Ali Fatehi, Kjelstrom, Stephanie, Montone, Georgia, Wertan, Mary Ann, Ramlawi, Basel, and Sutter, Francis P.

Published
2024
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6. Clinical Outcomes and Cost Analysis in Patients with Heart Failure Undergoing Transcatheter Edge-to-Edge Repair for Mitral Valve Regurgitation.

Author

Dokollari, Aleksander, Sicouri, Serge, Rodriguez, Roberto, Gnall, Eric, Coady, Paul, Mahmud, Farah, Kjelstrom, Stephanie, Montone, Georgia, Yamashita, Yoshiyuki, Harish, Jarrett, Bacchi, Beatrice, Arora, Rakesh C, Shah, Ashish, Ghorpade, Nitin, Abramson, Sandra, Hawthorne, Katie, Goldman, Scott, Gray, William, Cabrucci, Francesco, and Bonacchi, Massimo

Subjects
HEART failure patients, MITRAL valve, INTENSIVE care units, HOSPITAL costs, MYOCARDIAL infarction, HEART failure, MITRAL valve insufficiency
Abstract

Objective: To analyze the clinical and cost outcomes of transcatheter edge-to-edge repair (TEER) for mitral regurgitation (MR) in heart failure (HF) patients. Methods: All 162 HF patients undergoing TEER for MR between January 2019 and March 2023 were included. A propensity-adjusted analysis was used to compare 32 systolic vs. 97 diastolic vs. 33 mixed (systolic + diastolic) HF patients. Systolic, diastolic, and mixed HF patients were defined according to AHA guidelines. The primary outcome was the long-term incidence of all-cause death and major adverse cardiovascular and cerebrovascular events (MACCEs, all-cause mortality + stroke + myocardial infarction + repeat intervention). Results: The mean age was 76.3 vs. 80.9 vs. 76 years old, and the mean ejection fraction (EF) was 39.5% vs. 59.8% vs. 39.7% in systolic vs. diastolic vs. mixed HF, respectively. Postoperatively, the diastolic vs. systolic HF group had a higher intensive care unit stay (21 vs. 0 h; HR 67.5 (23.7, 111.4)]; lower ventilation time [2 vs. 2.3 h; HR 49.4 (8.6, 90.2)]; lower EF [38% vs. 58.5%; HR 9.9 (3.7, 16.1)]. In addition, the diastolic vs. mixed HF groups had a lower incidence of EF < 50% (11 vs. 27 patients; HR 6.6 (1.6, 27.3) and a lower use of dialysis (one vs. three patients; HR 18.1 (1.1, 287.3), respectively. At a mean 1.6 years follow-up, all-cause death [HR 39.8 (26.2, 60.5)], MACCEs [HR 50.3 (33.7–75.1)], and new pacemaker implantations [HR 17.3 (8.7, 34.6)] were higher in the mixed group. There was no significant total hospital cost difference among the systolic (USD 106,859) vs. diastolic (USD 91,731) vs. mixed (USD 120,522) HF groups (p = 0.08). Conclusions: TEER for MR evidenced the worst postoperative and follow-up clinical outcomes in the mixed HF group compared to diastolic and systolic HF groups. No total hospital cost differences were observed. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Development of a Risk Score for Long-term Survival and MACCE After Coronary Artery Bypass Grafting Surgery

Author

Dokollari, Aleksander, primary, Rosati, Fabrizio, additional, Muneretto, Claudio, additional, Amabile, Andrea, additional, Pernoci, Marjela, additional, Gemelli, Marco, additional, Hassanabad, Ali Fatehi, additional, Sicouri, Serge, additional, Sicouri, Noah, additional, Yamashita, Yoshiyuki, additional, Baudo, Massimo, additional, Bonacchi, Massimo, additional, Cabrucci, Francesco, additional, Bacchi, Beatrice, additional, Ghorpade, Nitin, additional, Shah, Ashish, additional, Coku, Lindita, additional, Cameli, Matteo, additional, Mandoli, Giulia Elena, additional, Kjelstrom, Stephanie, additional, Montone, Georgia, additional, Wertan, MaryAnn, additional, Ramlawi, Basel, additional, DiMagli, Arnaldo, additional, and Sutter, Francis P., additional

Published
2024
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12. TCT-40 Long-Term Outcomes in Octogenarians After Robotic-Assisted Coronary Artery Bypass Grafting

Author

Dokollari, Aleksander, primary, Erten, Ozgun, additional, Bonacchi, Massimo, additional, Cabrucci, Francesco, additional, Bacchi, Beatrice, additional, Gnall, Eric, additional, Gemelli, Marco, additional, Kjelstrom, Stephanie, additional, Montone, Georgia, additional, Sicouri, Serge, additional, Rodriguez, Roberto, additional, Hassanabad, Ali Fatehi, additional, Goldman, Scott, additional, Wertan, Mary Ann, additional, and Sutter, Francis, additional

Published
2023
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14. Long-Term Prognosis of Patients With Takotsubo Syndrome

Author

Ghadri, Jelena R., Kato, Ken, Cammann, Victoria L., Gili, Sebastiano, Jurisic, Stjepan, Di Vece, Davide, Candreva, Alessandro, Ding, Katharina J., Micek, Jozef, Szawan, Konrad A., Bacchi, Beatrice, Bianchi, Rahel, Levinson, Rena A., Wischnewsky, Manfred, Seifert, Burkhardt, Schlossbauer, Susanne A., Citro, Rodolfo, Bossone, Eduardo, Münzel, Thomas, Knorr, Maike, Heiner, Susanne, D’Ascenzo, Fabrizio, Franke, Jennifer, Sarcon, Annahita, Napp, L. Christian, Jaguszewski, Milosz, Noutsias, Michel, Katus, Hugo A., Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Tschöpe, Carsten, Pieske, Burkert M., Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Hasenfuß, Gerd, Karakas, Mahir, Koenig, Wolfgang, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Banning, Adrian, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K.E. Juhani, Opolski, Grzegorz, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang, Empen, Klaus, Felix, Stephan B., Delmas, Clément, Lairez, Olivier, El-Battrawy, Ibrahim, Akin, Ibrahim, Borggrefe, Martin, Horowitz, John, Kozel, Martin, Tousek, Petr, Widimský, Petr, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, Winchester, David E., Ukena, Christian, Bax, Jeroen J., Prasad, Abhiram, Böhm, Michael, Lüscher, Thomas F., Ruschitzka, Frank, and Templin, Christian

Published
2018
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16. Long-Term Outcomes in Patients Undergoing Thoracic Endovascular Aortic Repair. Single Center Experience

Author

Dokollari, Aleksander, primary, Sicouri, Serge, additional, Torregrossa, Gianluca, additional, Rodriguez, Roberto, additional, Meisner, Robert, additional, Hirsch, Henry, additional, DiGiovanni, Vincent, additional, Uribe, Alexander, additional, Bacchi, Beatrice, additional, Cabrucci, Francesso, additional, Chiarello, Bruno, additional, Ramlawi, Basel, additional, and Bonacchi, Massimo, additional

Published
2023
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17. Severe Refractory Vasoplegic Shock Syndrome after OPCABG Successfully Treated with Hydroxycobalamin: A Case Report and Review of the Literature.

Author

Bacchi, Beatrice, Cabrucci, Francesco, Chiarello, Bruno, Dokollari, Aleksander, and Bonacchi, Massimo

Subjects
*LITERATURE reviews, *TREATMENT effectiveness, *CORONARY artery bypass, *CORONARY artery disease, *METHYLENE blue, *PERICARDIAL effusion
Abstract

Background: Vasoplegic shock syndrome (VSS) after an off-pump coronary artery bypass graft (OPCABG) is an extremely rare condition. Inotropic support is usually the first-line therapy, though it can precipitate several complications or be ineffective. We report the first case of severe refractory VSS after OPCABG successfully treated with hydroxycobalamin. Methods: A 77-year-old gentleman underwent OPCABG for three vessels coronary artery disease. Preoperative LV ejection fraction was 28%, and the patient before surgery started sacubitril/valsartan titrated, then, at the highest dose. Surgery was uneventful and, by the end of the procedure, TEE showed improved biventricular contractility. Results: The patient was transferred to the ICU without inotropic support, but soon developed hypotension. TEE ruled out pericardial tamponade and confirmed fair contractility. Norepinephrine was titrated to a medium-high dose, vasopressin was started and a Swan-Ganz catheter was placed. SVR was 480 dyn·s·cm−5. Despite aggressive pharmacologic treatment (including methylprednisolone and methylene blue), no improvements were noticed. Ten grams of hydroxycobalamin were administered. One hour later, hemodynamic status re-assessment showed SVR > 800 dyn·s·cm−5. Afterward, vasopressors were gradually reduced. Conclusions: Our case demonstrated the importance of adequate early treatment in VSS after OPCABG. This case report shows, for the first time, that hydroxycobalamin was effectively used to restore homeostasis. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Short And Long-Term Outcomes Of Minimally Invasive Aortic Valve Surgery According To Pleural Integrity Preservation.

Author

Bacchi, Beatrice, Cabrucci, Francesco, Chiarello, Bruno, Dokollari, Aleksander, and Bonacchi, Massimo

Subjects
AORTIC valve surgery, SURGICAL complications, AORTIC valve transplantation, PNEUMOTHORAX, INTENSIVE care units
Abstract

Background Pleura integrity is a significant parameter influencing the outcomes in conventional cardiac surgery interventions. The impact of pleural integrity preservation in minimally invasive surgery is still not widely investigated. This study aims to define the role of pleural integrity preservation (PPI) on short and long-term outcomes after minimally-invasive aortic valve replacement (MIAVR). METHODS Data from 2430 consecutive patients who underwent MIAVR between 1997-2022 were retrospectively collected. Patients were divided into two groups: patients with PPI versus not-pleura integrity preservation (not-PPI). PPI has considered the maintenance of the pleura closed without the need for a chest tube insertion at the end of the surgical procedure. The not-PPI group included patients treated by right anterior Mini-Thoracotomy (824) or Ministernotomy (154) requiring surgical pleural drainage. A propensity-matched analysis was used to compare the two groups (not-PPI vs PPI). The main outcome was all-cause incidence of postoperative respiratory complications. RESULTS After propensity-matching, 848 patients were included in each group (PPI and not-PPI). Mean followup time was 147.4 months. Post-operatively, not-PPI vs PPI patients had a longer intensive care unit stay (hours) (9.7 vs 17.3, p= 0.00003, respectively), and hospital length of stay (LOS) (days) (5.2 vs 8.9, p= 0.00002, respectively). The rate of respiratory complications, including incidence of pneumothorax and/or subcutaneous emphysema, pulmonary atelectasis, and pleural effusion events requiring thoracentesis/drainage, was significantly higher in the not-PPI vs PPI group. Thirty-day all-cause mortality was higher in not-PPI vs PPI (0.029 vs 0.010, p= 0.0028, respectively), (Table 1). CONCLUSIONS Not-PPI after MIAVR was associated with an increased incidence of postoperative complications, and increased LOS compared to PPI. Even long term survival was significantly better in the PPI group. Particularly, the not-PPI approach increased 4 folds the probability of long-term mortality. Therefore, a MIAVR-tailored patient-procedure approach to maintaining the pleura integrity seems positively impacts short- and long-term outcomes. [ABSTRACT FROM AUTHOR]

Published
2023

19. Early and Long-Term Clinical and Echocardiographic Outcomes of Sutureless vs. Sutured Bioprosthesis for Aortic Valve Replacement

Author

Dokollari, Aleksander, primary, Torregrossa, Gianluca, additional, Bisleri, Gianluigi, additional, Hassanabad, Ali Fatehi, additional, Sa, Michel Pompeu, additional, Sicouri, Serge, additional, Veshti, Altin, additional, Prifti, Edvin, additional, Bacchi, Beatrice, additional, Cabrucci, Francesco, additional, Ramlawi, Basel, additional, and Bonacchi, Massimo, additional

Published
2023
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20. Editorial: Insights in heart surgery: 2022

Author

Bonacchi, Massimo, primary, Bacchi, Beatrice, additional, Cabrucci, Francesco, additional, Tevaearai Stahel, Hendrik, additional, Jeenchen Chen, Robert, additional, and Dokollari, Aleksander, additional

Published
2023
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22. Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome: Results From the International Takotsubo Registry

Author

Di Vece, Davide, Citro, Rodolfo, Cammann, Victoria L., Kato, Ken, Gili, Sebastiano, Szawan, Konrad A., Micek, Jozef, Jurisic, Stjepan, Ding, Katharina J., Bacchi, Beatrice, Schwyzer, Moritz, Candreva, Alessandro, Bossone, Eduardo, D’Ascenzo, Fabrizio, Sarcon, Annahita, Franke, Jennifer, Napp, L. Christian, Jaguszewski, Milosz, Noutsias, Michel, Münzel, Thomas, Knorr, Maike, Heiner, Susanne, Katus, Hugo A., Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Tschöpe, Carsten, Pieske, Burkert M., Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Hasenfuβ, Gerd, Karakas, Mahir, Koenig, Wolfgang, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Banning, Adrian, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K.E. Juhani, Opolski, Grzegorz, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Crea, Filippo, Dichtl, Wolfgang, Empen, Klaus, Felix, Stephan B., Delmas, Clément, Lairez, Olivier, El-Battrawy, Ibrahim, Akin, Ibrahim, Borggrefe, Martin, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, Horowitz, John, Kozel, Martin, Tousek, Petr, Widimský, Petr, Winchester, David E., Ukena, Christian, Di Mario, Carlo, Prasad, Abhiram, Böhm, Michael, Bax, Jeroen J., Lüscher, Thomas F., Ruschitzka, Frank, Ghadri, Jelena R., and Templin, Christian

Published
2019
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25. Clinical Outcomes of Cryo Nerve Ablation Technique for Pain Management: An Exploratory Study in Patients Undergoing Left Thoracotomy Coronary Artery Bypass Grafting.

Author

Dokollari, Aleksander, Sicouri, Serge, Erten, Ozgun, Ramlawi, Basel, Cameli, Matteo, Mandoli, Giulia Elena, Bacchi, Beatrice, Cabrucci, Francesco, Sutter, Francis P., Kjelstrom, Stephanie, Montone, Georgia, Sicouri, Noah, Hosseinian, Leila, Bonacchi, Massimo, and Torregrossa, Gianluca

Abstract

Background: To investigate the impact of Cryo Nerve Block with cryoICE™ device utilization, on post-operative pain in patients undergoing isolated coronary artery bypass grafting (CABG) through left thoracotomy. Methods: All consecutive patients undergoing isolated CABG through left thoracotomy between July 2021 and July 2022 from a single surgeon were included in the study. Patients using the cryoICE™ device for nerve block were compared for baseline demographics and pre-operative characteristics with those that did not use the cryoICE™ device. A propensity-adjusted analysis was used to compare the two groups. The primary outcome was degree of incisional pain and numbness. Results: A total of 103 patients underwent isolated CABG through left thoracotomy. After matching, the cryoICE™ device was used for nerve block in 60 patients while the control group included 43 patients. Mean follow-up was 5.7 months. The cryoICE™ device group had a mean value of incisional pain at hospital discharge was 1.5 (scale 0-10) while at follow-up was 0.69 (scale 0-10). Mean values of skin numbness at hospital discharge were 1 (scale 0-10) and 0.57 (scale 0-10) at follow-up. After univariate analysis comparison of cryoICE™ device group (60 patients) versus non-cryoICE™ device group (43 patients), the total in-hospital morphine use was 49% lower in the cryoICE™ versus the non-cryoICE™ cohort (73.8 + 79.37 mg vs 144.1 + 118.99 mg). Conclusions: Good clinical outcomes were observed in patients undergoing isolated left thoracotomy CABG with cryoICE™ utilization, including a very low incidence of post-operative pain, numbness, and hypersensitivity for all comers. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Emerging Medical Treatment for Hypertrophic Cardiomyopathy

Author

Argirò, Alessia, primary, Zampieri, Mattia, additional, Berteotti, Martina, additional, Marchi, Alberto, additional, Tassetti, Luigi, additional, Zocchi, Chiara, additional, Iannone, Luisa, additional, Bacchi, Beatrice, additional, Cappelli, Francesco, additional, Stefàno, Pierluigi, additional, Marchionni, Niccolò, additional, and Olivotto, Iacopo, additional

Published
2021
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38. Prognostic relevance of GRACE risk score in Takotsubo syndrome

Author

Scudiero, Fernando, primary, Arcari, Luca, additional, Cacciotti, Luca, additional, De Vito, Elena, additional, Marcucci, Rossella, additional, Passaseo, Ilaria, additional, Limite, Luca Rosario, additional, Musumeci, Maria Beatrice, additional, Autore, Camillo, additional, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Sanna, Giuseppe D, additional, Bacchi, Beatrice, additional, Volpe, Massimo, additional, Di Mario, Carlo, additional, and Parodi, Guido, additional

Published
2020
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40. Prediction of short- and long-term mortality in takotsubo syndrome: the InterTAK Prognostic Score

Author

Wischnewsky, Manfred B, Candreva, Alessandro, Bacchi, Beatrice, Cammann, Victoria L, Kato, Ken, Szawan, Konrad A, Gili, Sebastiano, D'Ascenzo, Fabrizio, Dichtl, Wolfgang, Citro, Rodolfo, Bossone, Eduardo, Neuhaus, Michael, et al, and University of Zurich

Subjects
10209 Clinic for Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2019

41. Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry

Author

Gili, Sebastiano, Cammann, Victoria L, Schlossbauer, Susanne A, Kato, Ken, D'Ascenzo, Fabrizio, Di Vece, Davide, Jurisic, Stjepan, Micek, Jozef, Obeid, Slayman, Bacchi, Beatrice, Szawan, Konrad A, Famos, Flurina, Sarcon, Annahita, Levinson, Rena, Ding, Katharina J, Seifert, Burkhardt, Lenoir, Olivia, Bossone, Eduardo, Citro, Rodolfo, Franke, Jennifer, Napp, L Christian, Jaguszewski, Milosz, Noutsias, Michel, Münzel, Thomas, Knorr, Maike, Heiner, Susanne, Katus, Hugo A, Burgdorf, Christof, Schunkert, Heribert, Thiele, Holger, et al, and University of Zurich

Subjects
11459 Center for Molecular Cardiology, 10209 Clinic for Cardiology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2705 Cardiology and Cardiovascular Medicine
Published
2019

42. Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry

Author

Cammann, Victoria Lucia, Sarcon, Annahita, Ding, Katharina J, Seifert, Burkhardt, Kato, Ken, Di Vece, Davide, Szawan, Konrad A, Gili, Sebastiano, Jurisic, Stjepan, Bacchi, Beatrice, Micek, Jozef, Frangieh, Antonio H, Napp, L Christian, Lüscher, Thomas F, Ruschitzka, Frank, Ghadri, Jelena R, Templin, Christian, et al, and University of Zurich

Subjects
11459 Center for Molecular Cardiology, 10209 Clinic for Cardiology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2705 Cardiology and Cardiovascular Medicine
Published
2019
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43. Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry

Author

Cammann, Victoria L., Sarcon, Annahita, Ding, Katharina J., Seifert, Burkhardt, Kato, Ken, Di Vece, Davide, Szawan, Konrad A., Gili, Sebastiano, Jurisic, Stjepan, Bacchi, Beatrice, Micek, Jozef, Frangieh, Antonio H., Napp, L. Christian, Jaguszewski, Milosz, Bossone, Eduardo, Citro, Rodolfo, D'Ascenzo, Fabrizio, Franke, Jennifer, Noutsias, Michel, Knorr, Maike, Heiner, Susanne, Burgdorf, Christof, Koenig, Wolfgang, Thiele, Holger, Tschope, Carsten, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Banning, Adrian, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Dworakowski, Rafal, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Dichtl, Wolfgang, Delmas, Clement, Lairez, Olivier, Horowitz, John D., Kozel, Martin, Widimsky, Petr, Tousek, Petr, Winchester, David E., Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, El-Battrawy, Ibrahim, Akin, Ibrahim, Ukena, Christian, Bauersachs, Johann, Pieske, Burkert M., Hasenfuss, Gerd, Rottbauer, Wolfgang, Braun-Dullaeus, Ruediger C., Opolski, Grzegorz, MacCarthy, Philip, Felix, Stephan B., Borggrefe, Martin, Di Mario, Carlo, Crea, Filippo, Katus, Hugo A., Schunkert, Heribert, Munzel, Thomas, Bohm, Michael, Bax, Jeroen J., Prasad, Abhiram, Shinbane, Jerold, Luscher, Thomas F., Ruschitzka, Frank, Ghadri, Jelena R., Templin, Christian, Cammann, Victoria L., Sarcon, Annahita, Ding, Katharina J., Seifert, Burkhardt, Kato, Ken, Di Vece, Davide, Szawan, Konrad A., Gili, Sebastiano, Jurisic, Stjepan, Bacchi, Beatrice, Micek, Jozef, Frangieh, Antonio H., Napp, L. Christian, Jaguszewski, Milosz, Bossone, Eduardo, Citro, Rodolfo, D'Ascenzo, Fabrizio, Franke, Jennifer, Noutsias, Michel, Knorr, Maike, Heiner, Susanne, Burgdorf, Christof, Koenig, Wolfgang, Thiele, Holger, Tschope, Carsten, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Banning, Adrian, Cuculi, Florim, Kobza, Richard, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Dworakowski, Rafal, Kaiser, Christoph, Osswald, Stefan, Galiuto, Leonarda, Dichtl, Wolfgang, Delmas, Clement, Lairez, Olivier, Horowitz, John D., Kozel, Martin, Widimsky, Petr, Tousek, Petr, Winchester, David E., Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, El-Battrawy, Ibrahim, Akin, Ibrahim, Ukena, Christian, Bauersachs, Johann, Pieske, Burkert M., Hasenfuss, Gerd, Rottbauer, Wolfgang, Braun-Dullaeus, Ruediger C., Opolski, Grzegorz, MacCarthy, Philip, Felix, Stephan B., Borggrefe, Martin, Di Mario, Carlo, Crea, Filippo, Katus, Hugo A., Schunkert, Heribert, Munzel, Thomas, Bohm, Michael, Bax, Jeroen J., Prasad, Abhiram, Shinbane, Jerold, Luscher, Thomas F., Ruschitzka, Frank, Ghadri, Jelena R., and Templin, Christian

Abstract

Background-Clinical characteristics and outcomes of takotsubo syndrome (US) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short- and long-term outcomes in TTS patients with or without malignancy. Methods and Results-ITS patients were enrolled from the International Takotsubo Registry. The TTS cohort was divided into patients with and without malignancy to investigate differences in clinical characteristics and to assess short- and long-term mortality. A subanalysis was performed comparing long-term mortality between a subset of TTS patients with or without malignancy and acute coronary syndrome (ACS) patients with or without malignancy. Malignancy was observed in 16.6% of 1604 TTS patients. Patients with malignancy were older and more likely to have physical triggers, but less likely to have emotional triggers compared with those without malignancy. Long-term mortality was higher in patients with malignancy (P<0.001), while short-term outcome was comparable (P=0.17). In a subanalysis, long-term mortality was comparable between TTS patients with malignancies and ACS patients with malignancies (P=0.13). Malignancy emerged as an independent predictor of long-term mortality. Conclusions-A substantial number of TTS patients show an association with malignancy. History of malignancy might increase the risk for TTS, and therefore, appropriate screening for malignancy should be considered in these patients.

Published
2019

44. threatening meteor for cardiac surgeons: anomalous left main coronary origin in type A aortic dissection.

Author

Braconi, Lucio, Cabrucci, Francesco, Bacchi, Beatrice, and Bonacchi, Massimo

Subjects
AORTIC dissection, METEORS, SURGEONS, CORONARY arteries
Abstract

We present the case of a type A aortic dissection originating from the right coronary ostium and an intraoperative diagnosis of the entire coronary artery system originating from a single right-sided coronary ostium. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Long-Term Prognosis of Patients With Takotsubo Syndrome

Author

Ghadri, Jelena R, Kato, Ken, Cammann, Victoria L, Gili, Sebastiano, Jurisic, Stjepan, Di Vece, Davide, Candreva, Alessandro, Ding, Katharina J, Micek, Jozef, Szawan, Konrad A, Bacchi, Beatrice, Bianchi, Rahel, Seifert, Burkhardt, Schlossbauer, Susanne A, et al, and University of Zurich

Subjects
11459 Center for Molecular Cardiology, 10209 Clinic for Cardiology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2705 Cardiology and Cardiovascular Medicine
Published
2018
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46. Prediction of short‐ and long‐term mortality in takotsubo syndrome: the InterTAK Prognostic Score

Author

Wischnewsky, Manfred B., primary, Candreva, Alessandro, additional, Bacchi, Beatrice, additional, Cammann, Victoria L., additional, Kato, Ken, additional, Szawan, Konrad A., additional, Gili, Sebastiano, additional, D'Ascenzo, Fabrizio, additional, Dichtl, Wolfgang, additional, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Neuhaus, Michael, additional, Franke, Jennifer, additional, Sorici‐Barb, Ioana, additional, Jaguszewski, Milosz, additional, Noutsias, Michel, additional, Knorr, Maike, additional, Heiner, Susanne, additional, Burgdorf, Christof, additional, Kherad, Behrouz, additional, Tschöpe, Carsten, additional, Sarcon, Annahita, additional, Shinbane, Jerold, additional, Rajan, Lawrence, additional, Michels, Guido, additional, Pfister, Roman, additional, Cuneo, Alessandro, additional, Jacobshagen, Claudius, additional, Karakas, Mahir, additional, Koenig, Wolfgang, additional, Pott, Alexander, additional, Meyer, Philippe, additional, Arroja, Jose David, additional, Banning, Adrian, additional, Cuculi, Florim, additional, Kobza, Richard, additional, Fischer, Thomas A., additional, Vasankari, Tuija, additional, Airaksinen, K.E. Juhani, additional, Napp, L. Christian, additional, Budnik, Monika, additional, Dworakowski, Rafal, additional, MacCarthy, Philip, additional, Kaiser, Christoph, additional, Osswald, Stefan, additional, Galiuto, Leonarda, additional, Chan, Christina, additional, Bridgman, Paul, additional, Beug, Daniel, additional, Delmas, Clément, additional, Lairez, Olivier, additional, El‐Battrawy, Ibrahim, additional, Akin, Ibrahim, additional, Gilyarova, Ekaterina, additional, Shilova, Alexandra, additional, Gilyarov, Mikhail, additional, Kozel, Martin, additional, Tousek, Petr, additional, Winchester, David E., additional, Galuszka, Jan, additional, Ukena, Christian, additional, Poglajen, Gregor, additional, Carrilho‐Ferreira, Pedro, additional, Hauck, Christian, additional, Paolini, Carla, additional, Bilato, Claudio, additional, Prasad, Abhiram, additional, Rihal, Charanjit S., additional, Liu, Kan, additional, Schulze, P. Christian, additional, Bianco, Matteo, additional, Jörg, Lucas, additional, Rickli, Hans, additional, Nguyen, Thanh H., additional, Kobayashi, Yoshio, additional, Böhm, Michael, additional, Maier, Lars S., additional, Pinto, Fausto J., additional, Widimský, Petr, additional, Borggrefe, Martin, additional, Felix, Stephan B., additional, Opolski, Grzegorz, additional, Braun‐Dullaeus, Ruediger C., additional, Rottbauer, Wolfgang, additional, Hasenfuß, Gerd, additional, Pieske, Burkert M., additional, Schunkert, Heribert, additional, Thiele, Holger, additional, Bauersachs, Johann, additional, Katus, Hugo A., additional, Horowitz, John, additional, Di Mario, Carlo, additional, Münzel, Thomas, additional, Crea, Filippo, additional, Bax, Jeroen J., additional, Lüscher, Thomas F., additional, Ruschitzka, Frank, additional, Ghadri, Jelena R., additional, and Templin, Christian, additional

Published
2019
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47. Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry

Author

Cammann, Victoria L., primary, Sarcon, Annahita, additional, Ding, Katharina J., additional, Seifert, Burkhardt, additional, Kato, Ken, additional, Di Vece, Davide, additional, Szawan, Konrad A., additional, Gili, Sebastiano, additional, Jurisic, Stjepan, additional, Bacchi, Beatrice, additional, Micek, Jozef, additional, Frangieh, Antonio H., additional, Napp, L. Christian, additional, Jaguszewski, Milosz, additional, Bossone, Eduardo, additional, Citro, Rodolfo, additional, D'Ascenzo, Fabrizio, additional, Franke, Jennifer, additional, Noutsias, Michel, additional, Knorr, Maike, additional, Heiner, Susanne, additional, Burgdorf, Christof, additional, Koenig, Wolfgang, additional, Thiele, Holger, additional, Tschöpe, Carsten, additional, Rajan, Lawrence, additional, Michels, Guido, additional, Pfister, Roman, additional, Cuneo, Alessandro, additional, Jacobshagen, Claudius, additional, Karakas, Mahir, additional, Banning, Adrian, additional, Cuculi, Florim, additional, Kobza, Richard, additional, Fischer, Thomas A., additional, Vasankari, Tuija, additional, Airaksinen, K. E. Juhani, additional, Dworakowski, Rafal, additional, Kaiser, Christoph, additional, Osswald, Stefan, additional, Galiuto, Leonarda, additional, Dichtl, Wolfgang, additional, Delmas, Clément, additional, Lairez, Olivier, additional, Horowitz, John D., additional, Kozel, Martin, additional, Widimský, Petr, additional, Tousek, Petr, additional, Winchester, David E., additional, Gilyarova, Ekaterina, additional, Shilova, Alexandra, additional, Gilyarov, Mikhail, additional, El‐Battrawy, Ibrahim, additional, Akin, Ibrahim, additional, Ukena, Christian, additional, Bauersachs, Johann, additional, Pieske, Burkert M., additional, Hasenfuß, Gerd, additional, Rottbauer, Wolfgang, additional, Braun‐Dullaeus, Ruediger C., additional, Opolski, Grzegorz, additional, MacCarthy, Philip, additional, Felix, Stephan B., additional, Borggrefe, Martin, additional, Di Mario, Carlo, additional, Crea, Filippo, additional, Katus, Hugo A., additional, Schunkert, Heribert, additional, Münzel, Thomas, additional, Böhm, Michael, additional, Bax, Jeroen J., additional, Prasad, Abhiram, additional, Shinbane, Jerold, additional, Lüscher, Thomas F., additional, Ruschitzka, Frank, additional, Ghadri, Jelena R., additional, and Templin, Christian, additional

Published
2019
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48. Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry

Author

Gili, Sebastiano, primary, Cammann, Victoria L, additional, Schlossbauer, Susanne A, additional, Kato, Ken, additional, D’Ascenzo, Fabrizio, additional, Di Vece, Davide, additional, Jurisic, Stjepan, additional, Micek, Jozef, additional, Obeid, Slayman, additional, Bacchi, Beatrice, additional, Szawan, Konrad A, additional, Famos, Flurina, additional, Sarcon, Annahita, additional, Levinson, Rena, additional, Ding, Katharina J, additional, Seifert, Burkhardt, additional, Lenoir, Olivia, additional, Bossone, Eduardo, additional, Citro, Rodolfo, additional, Franke, Jennifer, additional, Napp, L Christian, additional, Jaguszewski, Milosz, additional, Noutsias, Michel, additional, Münzel, Thomas, additional, Knorr, Maike, additional, Heiner, Susanne, additional, Katus, Hugo A, additional, Burgdorf, Christof, additional, Schunkert, Heribert, additional, Thiele, Holger, additional, Bauersachs, Johann, additional, Tschöpe, Carsten, additional, Pieske, Burkert M, additional, Rajan, Lawrence, additional, Michels, Guido, additional, Pfister, Roman, additional, Cuneo, Alessandro, additional, Jacobshagen, Claudius, additional, Hasenfuß, Gerd, additional, Karakas, Mahir, additional, Koenig, Wolfgang, additional, Rottbauer, Wolfgang, additional, Said, Samir M, additional, Braun-Dullaeus, Ruediger C, additional, Banning, Adrian, additional, Cuculi, Florim, additional, Kobza, Richard, additional, Fischer, Thomas A, additional, Vasankari, Tuija, additional, Airaksinen, K E Juhani, additional, Opolski, Grzegorz, additional, Dworakowski, Rafal, additional, MacCarthy, Philip, additional, Kaiser, Christoph, additional, Osswald, Stefan, additional, Galiuto, Leonarda, additional, Crea, Filippo, additional, Dichtl, Wolfgang, additional, Empen, Klaus, additional, Felix, Stephan B, additional, Delmas, Clément, additional, Lairez, Olivier, additional, El-Battrawy, Ibrahim, additional, Akin, Ibrahim, additional, Borggrefe, Martin, additional, Gilyarova, Ekaterina, additional, Shilova, Alexandra, additional, Gilyarov, Mikhail, additional, Horowitz, John D, additional, Kozel, Martin, additional, Tousek, Petr, additional, Widimský, Petr, additional, Winchester, David E, additional, Ukena, Christian, additional, Gaita, Fiorenzo, additional, Di Mario, Carlo, additional, Wischnewsky, Manfred B, additional, Bax, Jeroen J, additional, Prasad, Abhiram, additional, Böhm, Michael, additional, Ruschitzka, Frank, additional, Lüscher, Thomas F, additional, Ghadri, Jelena R, additional, and Templin, Christian, additional

Published
2019
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49. Takotsubo Recurrence

Author

Kato, Ken, primary, Di Vece, Davide, additional, Cammann, Victoria L., additional, Micek, Jozef, additional, Szawan, Konrad A., additional, Bacchi, Beatrice, additional, Lüscher, Thomas F., additional, Ruschitzka, Frank, additional, Ghadri, Jelena R., additional, and Templin, Christian, additional

Published
2019
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50. Hydroxycobalamin In Severe Refractory Vasoplegic Shock Syndrome After Off-Pump CABG.

Author

Bacchi, Beatrice, Cabrucci, Francesco, Chiarello, Bruno, Dokollari, Aleksander, and Bonacchi, Massimo

Subjects
VITAMIN B12, CORONARY artery bypass, VENTRICULAR ejection fraction, TRANSESOPHAGEAL echocardiography, VASOCONSTRICTORS
Abstract

Background: Vasoplegic shock syndrome (VSS) complicates up to 3% of off-pump coronary artery bypass grafting (OPCABG) cases. While VSS following on-pump cardiac surgery using cardiopulmonary bypass (CPB) is better understood, the mechanism and therapy for VSS after OPCABG are not well described. We report, to our knowledge, the first case of severe refractory VSS after OPCABG successfully treated with an infusion of hydroxycobalamin. Methods: A 61-year-old male underwent elective four-vessel OPCABG for severe triple vessel coronary artery disease. Left ventricular ejection fraction was 28%, and heart failure optimization included a two-week titration of sacubitril/valsartan. In addition, an intraortic balloon pump (IABP) was placed immediately preoperatively. Surgery was uneventful and after separation from CPB transesophageal echocardiography (TEE) showed improved biventricular contractility. Results: The patient was transferred to ICU without inotropic support. After one hour, the patient developed hypotension and hyperlactatemia addressed unsuccessfully with fluid administration and low-dose vasopressor. No bleeding was observed. TEE ruled out any pericardial tamponade and confirmed good contractility. Systemic vascular resistance (SVR) was calculated to be 480 dyn/cm5/s. Despite aggressive pharmacologic treatment, including up-titration of norepinephrine and vasopressin, as well as methylprednisolone, there was no improvement in MAP (< 50 mmHg) or SVR. Methylene blue infusion was commenced with no success and the patient remained profoundly vasoplegic. Hydroxycobalamin (10 g) was infused centrally. Within 30 minutes, the patient's MAP rose to 65 mmHg with a SVR>800 dyn/cm5/s. This improvement was sustained and in the next few hours, the SBP exceeded 90 mmHg. Vasopressors were weaned and hyperlactatemia improved. Conclusions: Our case demonstrates the importance of recognizing refractory VSS in cardiac surgery without the use of CPB, highlighting the role of the surgical procedure itself as causing severe systemic inflammation. Sacubitril-Valsartan, recently started, exacerbated the effect in this patient. Previously described only in the therapy of VSS in on-pump cardiac procedures, hydroxycobalamin played a crucial role in restoring hemodynamics in this setting. Hydroxycobalamin, a nitric oxide scavenger, has a more favorable safety profile than methylene blue(MB), and we propose that it should be used prior to MB in VSS. With our case study, we hope to encourage further research in this area. [ABSTRACT FROM AUTHOR]

Published
2023

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