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3. INFLUENCE OF DIFFERENT LIVING HINGES GEOMETRIES TO COMPLIANT STRAIGHT LINE MECHANISM TRAJECTORY

Author

Boris KOSIC, Ana PETROVIC, Marija BACKOVIC, Radoslav SURLA, and Zorana JELI

Subjects
straight-line mechanism, compliant mechanism, compliant hinge geometry, 3D modelling, Simulation, Architectural engineering. Structural engineering of buildings, TH845-895, Engineering design, TA174
Abstract

Classical straight-line mechanisms are one of the most interesting, both from a theoretical and practical point of view. In many cases, those mechanisms frequently produce a nearly straight trajectory rather than one perfectly straight. In compliant form, those mechanisms can produce even better results. Compliant mechanism joints' deformability allows engineers to make further modifications. These modifications may improve the mechanism's ability to follow a straight path even further. This paper will provide an analysis of different hinge sizes, thicknesses, shapes, and overall geometrical characteristics. Their influence on the straightness of the mechanism trajectory will be analyzed and quantified.

Published
2024

8. Novel Competitive ELISA Utilizing Trimeric Spike Protein of SARS-CoV-2, Could Identify More Than RBD-RBM Specific Neutralizing Antibodies in Hybrid Sera

Author

Petros Eliadis, Annie Mais, Alexandros Papazisis, Eleni K. Loxa, Alexios Dimitriadis, Ioannis Sarrigeorgiou, Marija Backovic, Maria Agallou, Marios Zouridakis, Evdokia Karagouni, Konstantinos Lazaridis, Avgi Mamalaki, and Peggy Lymberi

Subjects
SARS-CoV-2, surrogate viral neutralization assay (sVNA), trimeric S(6P)-HexaPro, non-RBD-RBM neutralizing antibodies (nAbs), Medicine
Abstract

Since the initiation of the COVID-19 pandemic, there has been a need for the development of diagnostic methods to determine the factors implicated in mounting an immune response against the virus. The most promising indicator has been suggested to be neutralizing antibodies (nAbs), which mainly block the interaction between the Spike protein (S) of SARS-CoV-2 and the host entry receptor ACE2. In this study, we aimed to develop and optimize conditions of a competitive ELISA to measure serum neutralizing titer, using a recombinant trimeric Spike protein modified to have six additional proline residues (S(6P)-HexaPro) and h-ACE2. The results of our surrogate Virus Neutralizing Assay (sVNA) were compared against the commercial sVNT (cPass, Nanjing GenScript Biotech Co., Nanjing City, China), using serially diluted sera from vaccinees, and a high correlation of ID50–90 titer values was observed between the two assays. Interestingly, when we tested and compared the neutralizing activity of sera from eleven fully vaccinated individuals who subsequently contracted COVID-19 (hybrid sera), we recorded a moderate correlation between the two assays, while higher sera neutralizing titers were measured with sVNA. Our data indicated that the sVNA, as a more biologically relevant model assay that paired the trimeric S(6P) with ACE2, instead of the isolated RBD-ACE2 pairing cPass test, could identify nAbs other than the RBD-RBM specific ones.

Published
2024
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10. The Large Hadron-Electron Collider at the HL-LHC

Author

Agostini, P., Aksakal, H., Alekhin, S., Allport, P. P., Andari, N., Andre, K. D. J., Angal-Kalinin, D., Antusch, S., Bella, L. Aperio, Apolinario, L., Apsimon, R., Apyan, A., Arduini, G., Ari, V., Armbruster, A., Armesto, N., Auchmann, B., Aulenbacher, K., Azuelos, G., Backovic, S., Bailey, I., Bailey, S., Balli, F., Behera, S., Behnke, O., Ben-Zvi, I., Benedikt, M., Bernauer, J., Bertolucci, S., Biswal, S. S., Blümlein, J., Bogacz, A., Bonvini, M., Boonekamp, M., Bordry, F., Boroun, G. R., Bottura, L., Bousson, S., Bouzas, A. O., Bracco, C., Bracinik, J., Britzger, D., Brodsky, S. J., Bruni, C., Brüning, O., Burkhardt, H., Cakir, O., Calaga, R., Caldwell, A., Calıskan, A., Camarda, S., Catalan-Lasheras, N. C., Cassou, K., Cepila, J., Cetinkaya, V., Chetvertkova, V., Cole, B., Coleppa, B., Cooper-Sarkar, A., Cormier, E., Cornell, A. S., Corsini, R., Cruz-Alaniz, E., Currie, J., Curtin, D., D'Onofrio, M., Dainton, J., Daly, E., Das, A., Das, S. P., Dassa, L., de Blas, J., Rose, L. Delle, Denizli, H., Deshpande, K. S., Douglas, D., Duarte, L., Dupraz, K., Dutta, S., Efremov, A. V., Eichhorn, R., Eskola, K. J., Ferreiro, E. G., Fischer, O., Flores-Sánchez, O., Forte, S., Gaddi, A., Gao, J., Gehrmann, T., Ridder, A. Gehrmann-De, Gerigk, F., Gilbert, A., Giuli, F., Glazov, A., Glover, N., Godbole, R. M., Goddard, B., Gonçalves, V., Gonzalez-Sprinberg, G. A., Goyal, A., Grames, J., Granados, E., Grassellino, A., Gunaydin, Y. O., Guo, Y. C., Guzey, V., Gwenlan, C., Hammad, A., Han, C. C., Harland-Lang, L., Haug, F., Hautmann, F., Hayden, D., Hessler, J., Helenius, I., Henry, J., Hernandez-Sanchez, J., Hesari, H., Hobbs, T. J., Hod, N., Hoffstaetter, G. H., Holzer, B., Honorato, C. G., Hounsell, B., Hu, N., Hug, F., Huss, A., Hutton, A., Islam, R., Iwamoto, S., Jana, S., Jansova, M., Jensen, E., Jones, T., Jowett, J. M., Kaabi, W., Kado, M., Kalinin, D. A., Karadeniz, H., Kawaguchi, S., Kaya, U., Khalek, R. A., Khanpour, H., Kilic, A., Klein, M., Klein, U., Kluth, S., Köksal, M., Kocak, F., Korostelev, M., Kostka, P., Krelina, M., Kretzschmar, J., Kuday, S., Kulipanov, G., Kumar, M., Kuze, M., Lappi, T., Larios, F., Latina, A., Laycock, P., Lei, G., Levitchev, E., Levonian, S., Levy, A., Li, R., Li, X., Liang, H., Litvinenko, V., Liu, M., Liu, T., Liu, W., Liu, Y., Liuti, S., Lobodzinska, E., Longuevergne, D., Luo, X., Ma, W., Machado, M., Mandal, S., Mäntysaari, H., Marhauser, F., Marquet, C., Martens, A., Martin, R., Marzani, S., McFayden, J., Mcintosh, P., Mellado, B., Meot, F., Milanese, A., Milhano, J. G., Militsyn, B., Mitra, M., Moch, S., Najafabadi, M. Mohammadi, Mondal, S., Moretti, S., Morgan, T., Morreale, A., Nadolsky, P., Navarra, F., Nergiz, Z., Newman, P., Niehues, J., Nissen, E. A., Nowakowski, M., Okada, N., Olivier, G., Olness, F., Olry, G., Osborne, J. A., Ozansoy, A., Pan, R., Parker, B., Patra, M., Paukkunen, H., Peinaud, Y., Pellegrini, D., Perez-Segurana, G., Perini, D., Perrot, L., Pietralla, N., Pilicer, E., Pire, B., Pires, J., Placakyte, R., Poelker, M., Polifka, R., Polini, A., Poulose, P., Pownall, G., Pupkov, Y. A., Queiroz, F. S., Rabbertz, K., Radescu, V., Rahaman, R., Rai, S. K., Raicevic, N., Ratoff, P., Rashed, A., Raut, D., Raychaudhuri, S., Repond, J., Rezaeian, A. H., Rimmer, R., Rinolfi, L., Rojo, J., Rosado, A., Ruan, X., Russenschuck, S., Sahin, M., Salgado, C. A., Sampayo, O. A., Satendra, K., Satyanarayan, N., Schenke, B., Schirm, K., Schopper, H., Schott, M., Schulte, D., Schwanenberger, C., Sekine, T., Senol, A., Seryi, A., Setiniyaz, S., Shang, L., Shen, X., Shipman, N., Sinha, N., Slominski, W., Smith, S., Solans, C., Song, M., Spiesberger, H., Stanyard, J., Starostenko, A., Stasto, A., Stocchi, A., Strikman, M., Stuart, M. J., Sultansoy, S., Sun, H., Sutton, M., Szymanowski, L., Tapan, I., Tapia-Takaki, D., Tanaka, M., Tang, Y., Tasci, A. T., Ten-Kate, A. T., Thonet, P., Tomas-Garcia, R., Tommasini, D., Trbojevic, D., Trott, M., Tsurin, I., Tudora, A., Cakir, I. Turk, Tywoniuk, K., Vallerand, C., Valloni, A., Verney, D., Vilella, E., Walker, D., Wallon, S., Wang, B., Wang, K., Wang, X., Wang, Z. S., Wei, H., Welsch, C., Willering, G., Williams, P. H., Wollmann, D., Xiaohao, C., Xu, T., Yaguna, C. E., Yamaguchi, Y., Yamazaki, Y., Yang, H., Yilmaz, A., Yock, P., Yue, C. X., Zadeh, S. G., Zenaiev, O., Zhang, C., Zhang, J., Zhang, R., Zhang, Z., Zhu, G., Zhu, S., Zimmermann, F., Zomer, F., Zurita, J., and Zurita, P.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment, Nuclear Theory
Abstract

The Large Hadron electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High Luminosity--Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operation. This report represents an update of the Conceptual Design Report (CDR) of the LHeC, published in 2012. It comprises new results on parton structure of the proton and heavier nuclei, QCD dynamics, electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics in extending the accessible kinematic range in lepton-nucleus scattering by several orders of magnitude. Due to enhanced luminosity, large energy and the cleanliness of the hadronic final states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, the report represents a detailed updated design of the energy recovery electron linac (ERL) including new lattice, magnet, superconducting radio frequency technology and further components. Challenges of energy recovery are described and the lower energy, high current, 3-turn ERL facility, PERLE at Orsay, is presented which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution and calibration goals which arise from the Higgs and parton density function physics programmes. The paper also presents novel results on the Future Circular Collider in electron-hadron mode, FCC-eh, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies., Comment: 373 pages, many figures, to be published by J. Phys. G

Published
2020
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13. Managing Costs of Renewable Energy Companies for Sustainable Business

Author

Backović, Nemanja, Ilić, Bojan, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Mihić, Marko, editor, Jednak, Sandra, editor, and Savić, Gordana, editor

Published
2023
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14. Predicting the survival probability of functional neuroendocrine tumors treated with peptide receptor radionuclide therapy: Serbian experience

Author

Vladimir Vukomanovic, Katarina Vuleta Nedic, Marija Zivkovic Radojevic, Aleksandar Dagovic, Neda Milosavljevic, Marina Markovic, Vladimir Ignjatovic, Ivana Simic Vukomanovic, Svetlana Djukic, Marijana Sreckovic, Milena Backovic, Marko Vuleta, Aleksandar Djukic, Verica Vukicevic, and Vesna Ignjatovic

Subjects
NET, PRRT, functional tumors, overall survival, progression free survival, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

IntroductionPeptide receptor radionuclide therapy (PRRT) is a treatment option for well-differentiated, somatostatin receptor positive, unresectable or/and metastatic neuroendocrine tumors (NETs). Although high disease control rates seen with PRRT a significant number NET patients have a short progression-free interval, and currently, there is a deficiency of effective biomarkers to pre-identify these patients. This study is aimed at determining the prognostic significance of biomarkers on survival of patients with NETs in initial PRRT treatment.MethodologyWe retrospectively analyzed 51 patients with NETs treated with PRRT at the Department for nuclear medicine, University Clinical Center Kragujevac, Serbia, with a five-year follow-up. Eligible patients with confirmed inoperable NETs, were retrospectively evaluated hematological, blood-based inflammatory markers, biochemical markers and clinical characteristics on disease progression. In accordance with the progression og the disease, the patients were divided into two groups: progression group (n=18) and a non-progression group (n=33). Clinical data were compared between the two groups.ResultsA total of 51 patients (Md=60, age 25-75 years) were treated with PRRT, of whom 29 (56.86%) demonstrated stable disease, 4 (7.84%) demonstrated a partial response, and 14 (27.46%) demonstrated progressive disease and death was recorded in 4 (7.84%) patients. The mean PFS was a 36.22 months (95% CI 30.14-42.29) and the mean OS was 44.68 months (95% CI 37.40-51.97). Univariate logistic regression analysis displayed that age (p

Published
2024
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15. The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells

Author

Ignacio Fernández, Lasse Toftdal Dynesen, Youna Coquin, Riccardo Pederzoli, Delphine Brun, Ahmed Haouz, Antoine Gessain, Félix A. Rey, Florence Buseyne, and Marija Backovic

Subjects
Science
Abstract

Foamy viruses are ancient retroviruses that are prevalent in non-human primates. Fernández et al. report an X-ray structure of a protein domain from a simian Foamy virus that mediates the attachment to cells, providing insights into viral entry.

Published
2023
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16. MadDM v.3.0: a Comprehensive Tool for Dark Matter Studies

Author

Ambrogi, Federico, Arina, Chiara, Backovic, Mihailo, Heisig, Jan, Maltoni, Fabio, Mantani, Luca, Mattelaer, Olivier, and Mohlabeng, Gopolang

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present MadDM v.3.0, a numerical tool to compute particle dark matter observables in generic new physics models. The new version features a comprehensive and automated framework for dark matter searches at the interface of collider physics, astrophysics and cosmology and is deployed as a plugin of the MadGraph5_aMC@NLO platform, inheriting most of its features. With respect to the previous version, MadDM v.3.0 can now provide predictions for indirect dark matter signatures in astrophysical environments, such as the annihilation cross section at present time and the energy spectra of prompt photons, cosmic rays and neutrinos resulting from dark matter annihilation. MadDM indirect detection features support both $2\to2$ and $2 \to n$ dark matter annihilation processes. In addition, the ability to compare theoretical predictions with experimental constraints is extended by including the Fermi-LAT likelihood for gamma-ray constraints from dwarf spheroidal galaxies and by providing an interface with the nested sampling algorithm PyMultinNest to perform high dimensional parameter scans efficiently. We validate the code for a wide set of dark matter models by comparing the results from MadDM v.3.0 to existing tools and results in the literature., Comment: 42 pages + references, 13 figures, 2 tables. Revised version matches the published version, minor changes

Published
2018
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17. Concertino for piano and orchestra

Author

Backovic, Jovana

Abstract

This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.

Published
2020

18. Recommendations of the LHC Dark Matter Working Group: Comparing LHC searches for dark matter mediators in visible and invisible decay channels and calculations of the thermal relic density

Author

Albert, Andreas, Backovic, Mihailo, Boveia, Antonio, Buchmueller, Oliver, Busoni, Giorgio, De Roeck, Albert, Doglioni, Caterina, DuPree, Tristan, Fairbairn, Malcolm, Genest, Marie-Helene, Gori, Stefania, Gustavino, Giuliano, Hahn, Kristian, Haisch, Ulrich, Harris, Philip C, Hayden, Dan, Ippolito, Valerio, John, Isabelle, Kahlhoefer, Felix, Kulkarni, Suchita, Landsberg, Greg, Lowette, Steven, Mawatari, Kentarou, Riotto, Antonio, Shepherd, William, Tait, Tim MP, Tolley, Emma, Tunney, Patrick, Zaldivar, Bryan, and Zinser, Markus

Subjects
Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Published
2019

19. Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics

Author

Matteo Broketa, Aurélien Sokal, Michael Mor, Pablo Canales-Herrerias, Angga Perima, Annalisa Meola, Ignacio Fernández, Bruno Iannascoli, Guilhem Chenon, Alexis Vandenberghe, Laetitia Languille, Marc Michel, Bertrand Godeau, Sébastien Gallien, Giovanna Melica, Marija Backovic, Felix A. Rey, Jean Baudry, Natalia T. Freund, Matthieu Mahévas, and Pierre Bruhns

Subjects
Immunology, Vaccines, Medicine
Abstract

SARS-CoV-2 mRNA vaccination generates protective B cell responses targeting the SARS-CoV-2 spike glycoprotein. Whereas anti-spike memory B cell responses are long lasting, the anti-spike humoral antibody response progressively wanes, making booster vaccinations necessary for maintaining protective immunity. Here, we qualitatively investigated the plasmablast responses by measuring from single cells within hours of sampling the affinity of their secreted antibody for the SARS-CoV-2 spike receptor binding domain (RBD) in cohorts of BNT162b2-vaccinated naive and COVID-19–recovered individuals. Using a droplet microfluidic and imaging approach, we analyzed more than 4,000 single IgG-secreting cells, revealing high interindividual variability in affinity for RBD, with variations over 4 logs. High-affinity plasmablasts were induced by BNT162b2 vaccination against Hu-1 and Omicron RBD but disappeared quickly thereafter, whereas low-affinity plasmablasts represented more than 65% of the plasmablast response at all time points. Our droplet-based method thus proves efficient at fast and qualitative immune monitoring and should be helpful for optimization of vaccination protocols.

Published
2023
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20. Impact of diabetes on the management and outcomes in atrial fibrillation: an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

Author

Boriani, G., Lip, G.Y.H., Tavazzi, L., Maggioni, A.P., Dan, G.-A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Simantirakis, E., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K.A., Erglis, A., Poposka, L., Burg, M., Crijns, H., Erküner, Ö., Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Lane, D., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., Van Genechten, G., Heidbuchel, H., Boussy, T., De Coninck, M., Van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., Van Hauwaert, B., Kuppens, C., Faes, D., Van Lier, D., Van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., Le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., Le Bidan, M., Pavin, D., Le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., Da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., Di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V.L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., De Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., Van Es, J., Van Opstal, J., Van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-Łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Mijatovic, A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I.E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A.K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U.O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M.B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Ding, Wern Yew, Kotalczyk, Agnieszka, Boriani, Giuseppe, Marin, Francisco, Blomström-Lundqvist, Carina, Potpara, Tatjana S., Fauchier, Laurent, and Lip, Gregory.Y.H.

Published
2022
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21. Presence

Author

Backovic, Nick and Todorovic, Dragan

Subjects
820, P Language and Literature
Published
2019

22. Cardiac troponins and adverse outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EORP atrial fibrillation general long-term registry

Author

Boriani, G., Lip, G.Y.H., Tavazzi, L., Maggioni, A.P., Dan, G-A., Potpara, T., Nabauer, M., Marin, F., Kalarus, Z., Fauchier, L., Goda, A., Mairesse, G., Shalganov, T., Antoniades, L., Taborsky, M., Riahi, S., Muda, P., García Bolao, I., Piot, O., Etsadashvili, K., Haim, M., Azhari, A., Najafian, J., Santini, M., Mirrakhimov, E., Kulzida, K., Erglis, A., Poposka, L., Burg, M.R., Crijns, H., Erküner, Ö., Atar, D., Lenarczyk, R., Martins Oliveira, M., Shah, D., Serdechnaya, E., Diker, E., Zëra, E., Ekmekçiu, U., Paparisto, V., Tase, M., Gjergo, H., Dragoti, J., Ciutea, M., Ahadi, N., el Husseini, Z., Raepers, M., Leroy, J., Haushan, P., Jourdan, A., Lepiece, C., Desteghe, L., Vijgen, J., Koopman, P., Van Genechten, G., Heidbuchel, H., Boussy, T., De Coninck, M., Van Eeckhoutte, H., Bouckaert, N., Friart, A., Boreux, J., Arend, C., Evrard, P., Stefan, L., Hoffer, E., Herzet, J., Massoz, M., Celentano, C., Sprynger, M., Pierard, L., Melon, P., Van Hauwaert, B., Kuppens, C., Faes, D., Van Lier, D., Van Dorpe, A., Gerardy, A., Deceuninck, O., Xhaet, O., Dormal, F., Ballant, E., Blommaert, D., Yakova, D., Hristov, M., Yncheva, T., Stancheva, N., Tisheva, S., Tokmakova, M., Nikolov, F., Gencheva, D., Kunev, B., Stoyanov, M., Marchov, D., Gelev, V., Traykov, V., Kisheva, A., Tsvyatkov, H., Shtereva, R., Bakalska-Georgieva, S., Slavcheva, S., Yotov, Y., Kubíčková, M., Marni Joensen, A., Gammelmark, A., Hvilsted Rasmussen, L., Dinesen, P., Krogh Venø, S., Sorensen, B., Korsgaard, A., Andersen, K., Fragtrup Hellum, C., Svenningsen, A., Nyvad, O., Wiggers, P., May, O., Aarup, A., Graversen, B., Jensen, L., Andersen, M., Svejgaard, M., Vester, S., Hansen, S., Lynggaard, V., Ciudad, M., Vettus, R., Maestre, A., Castaño, S., Cheggour, S., Poulard, J., Mouquet, V., Leparrée, S., Bouet, J., Taieb, J., Doucy, A., Duquenne, H., Furber, A., Dupuis, J., Rautureau, J., Font, M., Damiano, P., Lacrimini, M., Abalea, J., Boismal, S., Menez, T., Mansourati, J., Range, G., Gorka, H., Laure, C., Vassalière, C., Elbaz, N., Lellouche, N., Djouadi, K., Roubille, F., Dietz, D., Davy, J., Granier, M., Winum, P., Leperchois-Jacquey, C., Kassim, H., Marijon, E., Le Heuzey, J., Fedida, J., Maupain, C., Himbert, C., Gandjbakhch, E., Hidden-Lucet, F., Duthoit, G., Badenco, N., Chastre, T., Waintraub, X., Oudihat, M., Lacoste, J., Stephan, C., Bader, H., Delarche, N., Giry, L., Arnaud, D., Lopez, C., Boury, F., Brunello, I., Lefèvre, M., Mingam, R., Haissaguerre, M., Le Bidan, M., Pavin, D., Le Moal, V., Leclercq, C., Beitar, T., Martel, I., Schmid, A., Sadki, N., Romeyer-Bouchard, C., Da Costa, A., Arnault, I., Boyer, M., Piat, C., Lozance, N., Nastevska, S., Doneva, A., Fortomaroska Milevska, B., Sheshoski, B., Petroska, K., Taneska, N., Bakrecheski, N., Lazarovska, K., Jovevska, S., Ristovski, V., Antovski, A., Lazarova, E., Kotlar, I., Taleski, J., Kedev, S., Zlatanovik, N., Jordanova, S., Bajraktarova Proseva, T., Doncovska, S., Maisuradze, D., Esakia, A., Sagirashvili, E., Lartsuliani, K., Natelashvili, N., Gumberidze, N., Gvenetadze, R., Gotonelia, N., Kuridze, N., Papiashvili, G., Menabde, I., Glöggler, S., Napp, A., Lebherz, C., Romero, H., Schmitz, K., Berger, M., Zink, M., Köster, S., Sachse, J., Vonderhagen, E., Soiron, G., Mischke, K., Reith, R., Schneider, M., Rieker, W., Boscher, D., Taschareck, A., Beer, A., Oster, D., Ritter, O., Adamczewski, J., Walter, S., Frommhold, A., Luckner, E., Richter, J., Schellner, M., Landgraf, S., Bartholome, S., Naumann, R., Schoeler, J., Westermeier, D., William, F., Wilhelm, K., Maerkl, M., Oekinghaus, R., Denart, M., Kriete, M., Tebbe, U., Scheibner, T., Gruber, M., Gerlach, A., Beckendorf, C., Anneken, L., Arnold, M., Lengerer, S., Bal, Z., Uecker, C., Förtsch, H., Fechner, S., Mages, V., Martens, E., Methe, H., Schmidt, T., Schaeffer, B., Hoffmann, B., Moser, J., Heitmann, K., Willems, S., Klaus, C., Lange, I., Durak, M., Esen, E., Mibach, F., Mibach, H., Utech, A., Gabelmann, M., Stumm, R., Ländle, V., Gartner, C., Goerg, C., Kaul, N., Messer, S., Burkhardt, D., Sander, C., Orthen, R., Kaes, S., Baumer, A., Dodos, F., Barth, A., Schaeffer, G., Gaertner, J., Winkler, J., Fahrig, A., Aring, J., Wenzel, I., Steiner, S., Kliesch, A., Kratz, E., Winter, K., Schneider, P., Haag, A., Mutscher, I., Bosch, R., Taggeselle, J., Meixner, S., Schnabel, A., Shamalla, A., Hötz, H., Korinth, A., Rheinert, C., Mehltretter, G., Schön, B., Schön, N., Starflinger, A., Englmann, E., Baytok, G., Laschinger, T., Ritscher, G., Gerth, A., Dechering, D., Eckardt, L., Kuhlmann, M., Proskynitopoulos, N., Brunn, J., Foth, K., Axthelm, C., Hohensee, H., Eberhard, K., Turbanisch, S., Hassler, N., Koestler, A., Stenzel, G., Kschiwan, D., Schwefer, M., Neiner, S., Hettwer, S., Haeussler-Schuchardt, M., Degenhardt, R., Sennhenn, S., Brendel, M., Stoehr, A., Widjaja, W., Loehndorf, S., Logemann, A., Hoskamp, J., Grundt, J., Block, M., Ulrych, R., Reithmeier, A., Panagopoulos, V., Martignani, C., Bernucci, D., Fantecchi, E., Diemberger, I., Ziacchi, M., Biffi, M., Cimaglia, P., Frisoni, J., Giannini, I., Boni, S., Fumagalli, S., Pupo, S., Di Chiara, A., Mirone, P., Pesce, F., Zoccali, C., Malavasi, V.L., Mussagaliyeva, A., Ahyt, B., Salihova, Z., Koshum-Bayeva, K., Kerimkulova, A., Bairamukova, A., Lurina, B., Zuzans, R., Jegere, S., Mintale, I., Kupics, K., Jubele, K., Kalejs, O., Vanhear, K., Burg, M., Cachia, M., Abela, E., Warwicker, S., Tabone, T., Xuereb, R., Asanovic, D., Drakalovic, D., Vukmirovic, M., Pavlovic, N., Music, L., Bulatovic, N., Boskovic, A., Uiterwaal, H., Bijsterveld, N., De Groot, J., Neefs, J., van den Berg, N., Piersma, F., Wilde, A., Hagens, V., Van Es, J., Van Opstal, J., Van Rennes, B., Verheij, H., Breukers, W., Tjeerdsma, G., Nijmeijer, R., Wegink, D., Binnema, R., Said, S., Philippens, S., van Doorn, W., Szili-Torok, T., Bhagwandien, R., Janse, P., Muskens, A., van Eck, M., Gevers, R., van der Ven, N., Duygun, A., Rahel, B., Meeder, J., Vold, A., Holst Hansen, C., Engset, I., Dyduch-Fejklowicz, B., Koba, E., Cichocka, M., Sokal, A., Kubicius, A., Pruchniewicz, E., Kowalik-Sztylc, A., Czapla, W., Mróz, I., Kozlowski, M., Pawlowski, T., Tendera, M., Winiarska-Filipek, A., Fidyk, A., Slowikowski, A., Haberka, M., Lachor-Broda, M., Biedron, M., Gasior, Z., Kołodziej, M., Janion, M., Gorczyca-Michta, I., Wozakowska-Kaplon, B., Stasiak, M., Jakubowski, P., Ciurus, T., Drozdz, J., Simiera, M., Zajac, P., Wcislo, T., Zycinski, P., Kasprzak, J., Olejnik, A., Harc-Dyl, E., Miarka, J., Pasieka, M., Ziemińska-Łuć, M., Bujak, W., Śliwiński, A., Grech, A., Morka, J., Petrykowska, K., Prasał, M., Hordyński, G., Feusette, P., Lipski, P., Wester, A., Streb, W., Romanek, J., Woźniak, P., Chlebuś, M., Szafarz, P., Stanik, W., Zakrzewski, M., Kaźmierczak, J., Przybylska, A., Skorek, E., Błaszczyk, H., Stępień, M., Szabowski, S., Krysiak, W., Szymańska, M., Karasiński, J., Blicharz, J., Skura, M., Hałas, K., Michalczyk, L., Orski, Z., Krzyżanowski, K., Skrobowski, A., Zieliński, L., Tomaszewska-Kiecana, M., Dłużniewski, M., Kiliszek, M., Peller, M., Budnik, M., Balsam, P., Opolski, G., Tymińska, A., Ozierański, K., Wancerz, A., Borowiec, A., Majos, E., Dabrowski, R., Szwed, H., Musialik-Lydka, A., Leopold-Jadczyk, A., Jedrzejczyk-Patej, E., Koziel, M., Mazurek, M., Krzemien-Wolska, K., Starosta, P., Nowalany-Kozielska, E., Orzechowska, A., Szpot, M., Staszel, M., Almeida, S., Pereira, H., Brandão Alves, L., Miranda, R., Ribeiro, L., Costa, F., Morgado, F., Carmo, P., Galvao Santos, P., Bernardo, R., Adragão, P., Ferreira da Silva, G., Peres, M., Alves, M., Leal, M., Cordeiro, A., Magalhães, P., Fontes, P., Leão, S., Delgado, A., Costa, A., Marmelo, B., Rodrigues, B., Moreira, D., Santos, J., Santos, L., Terchet, A., Darabantiu, D., Mercea, S., Turcin Halka, V., Pop Moldovan, A., Gabor, A., Doka, B., Catanescu, G., Rus, H., Oboroceanu, L., Bobescu, E., Popescu, R., Dan, A., Buzea, A., Daha, I., Dan, G., Neuhoff, I., Baluta, M., Ploesteanu, R., Dumitrache, N., Vintila, M., Daraban, A., Japie, C., Badila, E., Tewelde, H., Hostiuc, M., Frunza, S., Tintea, E., Bartos, D., Ciobanu, A., Popescu, I., Toma, N., Gherghinescu, C., Cretu, D., Patrascu, N., Stoicescu, C., Udroiu, C., Bicescu, G., Vintila, V., Vinereanu, D., Cinteza, M., Rimbas, R., Grecu, M., Cozma, A., Boros, F., Ille, M., Tica, O., Tor, R., Corina, A., Jeewooth, A., Maria, B., Georgiana, C., Natalia, C., Alin, D., Dinu-Andrei, D., Livia, M., Daniela, R., Larisa, R., Umaar, S., Tamara, T., Ioachim Popescu, M., Nistor, D., Sus, I., Coborosanu, O., Alina-Ramona, N., Dan, R., Petrescu, L., Ionescu, G., Vacarescu, C., Goanta, E., Mangea, M., Ionac, A., Mornos, C., Cozma, D., Pescariu, S., Solodovnicova, E., Soldatova, I., Shutova, J., Tjuleneva, L., Zubova, T., Uskov, V., Obukhov, D., Rusanova, G., Isakova, N., Odinsova, S., Arhipova, T., Kazakevich, E., Zavyalova, O., Novikova, T., Riabaia, I., Zhigalov, S., Drozdova, E., Luchkina, I., Monogarova, Y., Hegya, D., Rodionova, L., Nevzorova, V., Lusanova, O., Arandjelovic, A., Toncev, D., Vukmirovic, L., Radisavljevic, M., Milanov, M., Sekularac, N., Zdravkovic, M., Hinic, S., Dimkovic, S., Acimovic, T., Saric, J., Radovanovic, S., Kocijancic, A., Obrenovic-Kircanski, B., Kalimanovska Ostric, D., Simic, D., Jovanovic, I., Petrovic, I., Polovina, M., Vukicevic, M., Tomasevic, M., Mujovic, N., Radivojevic, N., Petrovic, O., Aleksandric, S., Kovacevic, V., Mijatovic, Z., Ivanovic, B., Tesic, M., Ristic, A., Vujisic-Tesic, B., Nedeljkovic, M., Karadzic, A., Uscumlic, A., Prodanovic, M., Zlatar, M., Asanin, M., Bisenic, B., Vasic, V., Popovic, Z., Djikic, D., Sipic, M., Peric, V., Dejanovic, B., Milosevic, N., Backovic, S., Stevanovic, A., Andric, A., Pencic, B., Pavlovic-Kleut, M., Celic, V., Pavlovic, M., Petrovic, M., Vuleta, M., Petrovic, N., Simovic, S., Savovic, Z., Milanov, S., Davidovic, G., Iric-Cupic, V., Djordjevic, D., Damjanovic, M., Zdravkovic, S., Topic, V., Stanojevic, D., Randjelovic, M., Jankovic-Tomasevic, R., Atanaskovic, V., Antic, S., Simonovic, D., Stojanovic, M., Stojanovic, S., Mitic, V., Ilic, V., Petrovic, D., Deljanin Ilic, M., Ilic, S., Stoickov, V., Markovic, S., Mijatovic, A., Tanasic, D., Radakovic, G., Peranovic, J., Panic-Jelic, N., Vujadinovic, O., Pajic, P., Bekic, S., Kovacevic, S., García Fernandez, A., Perez Cabeza, A., Anguita, M., Tercedor Sanchez, L., Mau, E., Loayssa, J., Ayarra, M., Carpintero, M., Roldán Rabadan, I., Gil Ortega, M., Tello Montoliu, A., Orenes Piñero, E., Manzano Fernández, S., Marín, F., Romero Aniorte, A., Veliz Martínez, A., Quintana Giner, M., Ballesteros, G., Palacio, M., Alcalde, O., García-Bolao, I., Bertomeu Gonzalez, V., Otero-Raviña, F., García Seara, J., Gonzalez Juanatey, J., Dayal, N., Maziarski, P., Gentil-Baron, P., Koç, M., Onrat, E., Dural, I.E., Yilmaz, K., Özin, B., Tan Kurklu, S., Atmaca, Y., Canpolat, U., Tokgozoglu, L., Dolu, A.K., Demirtas, B., Sahin, D., Ozcan Celebi, O., Gagirci, G., Turk, U.O., Ari, H., Polat, N., Toprak, N., Sucu, M., Akin Serdar, O., Taha Alper, A., Kepez, A., Yuksel, Y., Uzunselvi, A., Yuksel, S., Sahin, M., Kayapinar, O., Ozcan, T., Kaya, H., Yilmaz, M.B., Kutlu, M., Demir, M., Gibbs, C., Kaminskiene, S., Bryce, M., Skinner, A., Belcher, G., Hunt, J., Stancombe, L., Holbrook, B., Peters, C., Tettersell, S., Shantsila, A., Lane, D., Senoo, K., Proietti, M., Russell, K., Domingos, P., Hussain, S., Partridge, J., Haynes, R., Bahadur, S., Brown, R., McMahon, S., McDonald, J., Balachandran, K., Singh, R., Garg, S., Desai, H., Davies, K., Goddard, W., Galasko, G., Rahman, I., Chua, Y., Payne, O., Preston, S., Brennan, O., Pedley, L., Whiteside, C., Dickinson, C., Brown, J., Jones, K., Benham, L., Brady, R., Buchanan, L., Ashton, A., Crowther, H., Fairlamb, H., Thornthwaite, S., Relph, C., McSkeane, A., Poultney, U., Kelsall, N., Rice, P., Wilson, T., Wrigley, M., Kaba, R., Patel, T., Young, E., Law, J., Runnett, C., Thomas, H., McKie, H., Fuller, J., Pick, S., Sharp, A., Hunt, A., Thorpe, K., Hardman, C., Cusack, E., Adams, L., Hough, M., Keenan, S., Bowring, A., Watts, J., Zaman, J., Goffin, K., Nutt, H., Beerachee, Y., Featherstone, J., Mills, C., Pearson, J., Stephenson, L., Grant, S., Wilson, A., Hawksworth, C., Alam, I., Robinson, M., Ryan, S., Egdell, R., Gibson, E., Holland, M., Leonard, D., Mishra, B., Ahmad, S., Randall, H., Hill, J., Reid, L., George, M., McKinley, S., Brockway, L., Milligan, W., Sobolewska, J., Muir, J., Tuckis, L., Winstanley, L., Jacob, P., Kaye, S., Morby, L., Jan, A., Sewell, T., Boos, C., Wadams, B., Cope, C., Jefferey, P., Andrews, N., Getty, A., Suttling, A., Turner, C., Hudson, K., Austin, R., Howe, S., Iqbal, R., Gandhi, N., Brophy, K., Mirza, P., Willard, E., Collins, S., Ndlovu, N., Subkovas, E., Karthikeyan, V., Waggett, L., Wood, A., Bolger, A., Stockport, J., Evans, L., Harman, E., Starling, J., Williams, L., Saul, V., Sinha, M., Bell, L., Tudgay, S., Kemp, S., Frost, L., Ingram, T., Loughlin, A., Adams, C., Adams, M., Hurford, F., Owen, C., Miller, C., Donaldson, D., Tivenan, H., Button, H., Nasser, A., Jhagra, O., Stidolph, B., Brown, C., Livingstone, C., Duffy, M., Madgwick, P., Roberts, P., Greenwood, E., Fletcher, L., Beveridge, M., Earles, S., McKenzie, D., Beacock, D., Dayer, M., Seddon, M., Greenwell, D., Luxton, F., Venn, F., Mills, H., Rewbury, J., James, K., Roberts, K., Tonks, L., Felmeden, D., Taggu, W., Summerhayes, A., Hughes, D., Sutton, J., Felmeden, L., Khan, M., Walker, E., Norris, L., O'Donohoe, L., Mozid, A., Dymond, H., Lloyd-Jones, H., Saunders, G., Simmons, D., Coles, D., Cotterill, D., Beech, S., Kidd, S., Wrigley, B., Petkar, S., Smallwood, A., Jones, R., Radford, E., Milgate, S., Metherell, S., Cottam, V., Buckley, C., Broadley, A., Wood, D., Allison, J., Rennie, K., Balian, L., Howard, L., Pippard, L., Board, S., Pitt-Kerby, T., Vitolo, Marco, Malavasi, Vincenzo L., Proietti, Marco, Diemberger, Igor, Fauchier, Laurent, Marin, Francisco, Nabauer, Michael, Potpara, Tatjana S., Dan, Gheorghe-Andrei, Kalarus, Zbigniew, Tavazzi, Luigi, Maggioni, Aldo Pietro, Lane, Deirdre A., Lip, Gregory Y.H., and Boriani, Giuseppe

Published
2022
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23. Analysis of the Relationship Between Energy Consumption and Economic Growth in Transition Countries.

Author

Pejovic, Bojan, Backovic, Tamara, and Karadzic, Vesna

Subjects
CONSUMPTION (Economics), ENERGY consumption, GROSS domestic product, ECONOMIC impact, ECONOMIC expansion
Abstract

This paper investigates the relationship between economic growth and energy consumption in European transition countries. Cross-sectionally augmented autoregressive distributed lag and cross-sectionally augmented distributed lag models were used in the paper to investigate the relationship, while robustness was checked using several different estimators. The results confirm a positive relationship between the variables. Growth of the gross domestic product will lead to an increase in energy consumption in the long run, so transition countries should work on creating new sources of energy and improving energy efficiency. Policies based on limiting energy consumption can have a negative impact on economic growth. [ABSTRACT FROM AUTHOR]

Published
2025
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24. Probing Dark Matter Long-lived Mediators with Solar $\gamma$ rays

Author

Lucente, Michele, Arina, Chiara, Backović, Mihailo, and Heisig, Jan

Subjects
High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We show that solar $\gamma$-ray observations can provide a complementary probe of Dark Matter in scenarios where the interactions with the Standard Model proceed via long-lived mediators. For illustration we consider a simplified model which provides solar $\gamma$-ray fluxes observable with the next generation $\gamma$-ray telescopes, while complying with the existing experimental constraints. Our results suggest that solar $\gamma$-ray fluxes can be orders of magnitude larger than the ones from the Galactic center, while being subject to low backgrounds., Comment: 4 pages, 2 figures. To appear in the proceedings of The European Physical Society Conference on High Energy Physics, 5-12 July 2017 in Venice, Italy

Published
2017
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25. Solar $\gamma$-rays as a Complementary Probe of Dark Matter

Author

Arina, Chiara, Backović, Mihailo, Heisig, Jan, and Lucente, Michele

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Phenomenology
Abstract

We show that observations of solar $\gamma$-rays offer a novel probe of dark matter in scenarios where interactions with the visible sector proceed via a long-lived mediator. As a proof of principle, we demonstrate that there exists a class of models which yield solar $\gamma$-ray fluxes observable with the next generation of $\gamma$-ray telescopes, while being allowed by a variety of current experimental constraints. The parameter space allowed by big bang nucleosynthesis and beam dump experiments naturally leads to mediator lifetimes sufficient to produce observable solar $\gamma$-ray signals. The model allows for solar $\gamma$-ray fluxes up to orders of magnitude larger compared to dwarf spheroidal galaxies, without reaching equilibrium between dark matter annihilation and capture rate. Our results suggest that solar $\gamma$-ray observations are complementary, and in some cases superior, to existing and future dark matter detection efforts., Comment: 15 pages + references, 7 figures, v3: Fermi-LAT and HERD sensitivity corrected, minor presentational improvements, matches journal version

Published
2017
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26. Recommendations of the LHC Dark Matter Working Group: Comparing LHC searches for heavy mediators of dark matter production in visible and invisible decay channels

Author

Albert, Andreas, Backovic, Mihailo, Boveia, Antonio, Buchmueller, Oliver, Busoni, Giorgio, De Roeck, Albert, Doglioni, Caterina, DuPree, Tristan, Fairbairn, Malcolm, Genest, Marie-Helene, Gori, Stefania, Gustavino, Giuliano, Hahn, Kristian, Haisch, Ulrich, Harris, Philip C., Hayden, Dan, Ippolito, Valerio, John, Isabelle, Kahlhoefer, Felix, Kulkarni, Suchita, Landsberg, Greg, Lowette, Steven, Mawatari, Kentarou, Riotto, Antonio, Shepherd, William, Tait, Tim M. P., Tolley, Emma, Tunney, Patrick, Zaldivar, Bryan, and Zinser, Markus

Subjects
High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

Weakly-coupled TeV-scale particles may mediate the interactions between normal matter and dark matter. If so, the LHC would produce dark matter through these mediators, leading to the familiar "mono-X" search signatures, but the mediators would also produce signals without missing momentum via the same vertices involved in their production. This document from the LHC Dark Matter Working Group suggests how to compare searches for these two types of signals in case of vector and axial-vector mediators, based on a workshop that took place on September 19/20, 2016 and subsequent discussions. These suggestions include how to extend the spin-1 mediated simplified models already in widespread use to include lepton couplings. This document also provides analytic calculations of the relic density in the simplified models and reports an issue that arose when ATLAS and CMS first began to use preliminary numerical calculations of the dark matter relic density in these models., Comment: 19 pages, 4 figures; v2: author list and LaTeX problem fixed

Published
2017

28. Neutralization of zoonotic retroviruses by human antibodies: Genotype-specific epitopes within the receptor-binding domain from simian foamy virus.

Author

Lasse Toftdal Dynesen, Ignacio Fernandez, Youna Coquin, Manon Delaplace, Thomas Montange, Richard Njouom, Chanceline Bilounga-Ndongo, Félix A Rey, Antoine Gessain, Marija Backovic, and Florence Buseyne

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

Infection with viruses of animal origin pose a significant threat to human populations. Simian foamy viruses (SFVs) are frequently transmitted to humans, in which they establish a life-long infection, with the persistence of replication-competent virus. However, zoonotic SFVs do not induce severe disease nor are they transmitted between humans. Thus, SFVs represent a model of zoonotic retroviruses that lead to a chronic infection successfully controlled by the human immune system. We previously showed that infected humans develop potent neutralizing antibodies (nAbs). Within the viral envelope (Env), the surface protein (SU) carries a variable region that defines two genotypes, overlaps with the receptor binding domain (RBD), and is the exclusive target of nAbs. However, its antigenic determinants are not understood. Here, we characterized nAbs present in plasma samples from SFV-infected individuals living in Central Africa. Neutralization assays were carried out in the presence of recombinant SU that compete with SU at the surface of viral vector particles. We defined the regions targeted by the nAbs using mutant SU proteins modified at the glycosylation sites, RBD functional subregions, and genotype-specific sequences that present properties of B-cell epitopes. We observed that nAbs target conformational epitopes. We identified three major epitopic regions: the loops at the apex of the RBD, which likely mediate interactions between Env protomers to form Env trimers, a loop located in the vicinity of the heparan binding site, and a region proximal to the highly conserved glycosylation site N8. We provide information on how nAbs specific for each of the two viral genotypes target different epitopes. Two common immune escape mechanisms, sequence variation and glycan shielding, were not observed. We propose a model according to which the neutralization mechanisms rely on the nAbs to block the Env conformational change and/or interfere with binding to susceptible cells. As the SFV RBD is structurally different from known retroviral RBDs, our data provide fundamental knowledge on the structural basis for the inhibition of viruses by nAbs. Trial registration: The study was registered at www.clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/NCT03225794/.

Published
2023
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30. Analyzing the factors influencing the formation of the price of electricity in the deregulated markets of developing countries

Author

Zdenka Dragasevic, Nikola Milovic, Vladimir Djurisic, and Tamara Backovic

Subjects
Developing countries, Deregulated electricity market, Regression model, Renewable energy sources, A dominant firm leadership model, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The aim of this paper is to measure the impact of certain factors on the formation of the price of electricity, which is obtained from conventional and renewable energy sources, in the deregulated markets of developing countries, such as Montenegro. Another goal is to identify and analyze the criteria that can lead to a change in the electricity market structure. This study was especially inspired by the fact that no similar research has been conducted in this domain, according to the authors’ knowledge. A regression model is applied in the paper, which can be used to display the fluctuation of electricity prices based on the analyzed factors. In addition to price as a dependent variable, the model also examined eight factors that are independent variables. Apart from the basic model, another model has been formulated which, in addition to a price as dependent variable and the examined factors, also takes into consideration the production of electricity from renewable sources. The results of the research showed that an increase in the amount of electricity produced will lead to a slight increase in price, which is to be expected considering there is still one large producer servicing the market, which, despite the deregulation of the market, still has significant monopoly power. The generation of electricity by small hydropower plants will not significantly affect price change, and these entities will behave as if they were in a market of perfect competition. Further opening up the market to new competitors would lead to a fall in the price of electricity. Based on the predicted capacity of electricity generation from small hydropower plants, the electricity deficit could be reduced; in another words it could lead to the reduction of imports. Based on the results of the study, energy policy makers will be able to adopt informed strategies and make decisions related to developments in the energy market, most notably the creation of a common EU energy market. Also, the results of the conducted research expand the theoretical body of work dealing with the determination of the price of electricity. Future studies could address the issue of using natural potential for the generation of electricity from renewable sources, such as solar energy, wind energy and other sources.

Published
2021
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32. Psychosocial school factors and mental health of first grade secondary school students-Results of the Health Behaviour in School-aged Children Survey in Serbia.

Author

Dragana Skoric, Jelena Gudelj Rakic, Verica Jovanovic, Dusan Backovic, Ivan Soldatovic, and Jelena Ilic Zivojinovic

Subjects
Medicine, Science
Abstract

This cross-sectional study aimed to investigate the association between psychosocial school factors and life satisfaction, symptoms of depression and psychosomatic health complaints among first grade secondary school students in Serbia. We analysed data from the 2018 Health Behaviour in School-aged Children (HBSC) study in the Republic of Serbia. Analyzed psychosocial school factors included satisfaction with school, schoolwork pressure, teacher support, classmate support and being bullied at school. Life satisfaction was assessed by the 11-step Cantril's ladder (cutoff >5). Symptoms of depression were measured by the Center for Epidemiologic Studies Depression Scale (CESD-10) and psychosomatic health complaints by using the HBSC symptom checklist. Univariable and multivariable binary logistic regression was used to determine independent predictors of students' life satisfaction, symptoms of depression and psychosomatic health complaints in the school environment, while also considering their socio-demographic characteristics and perceived family and friend support. The study included 1605 students (average age 15.26 ±0.44 years), of whom 50.3% were females. Results from the binary logistic regression analyses showed that life satisfaction was positively related to school satisfaction and classmate support, and negatively to being bullied at school. Symptoms of depression were positively associated with schoolwork pressure and being bullied at school, and negatively with teacher and classmate support. All analyzed factors of the school environment were significantly related to psychosomatic health complaints, whereby schoolwork pressure and being bullied at school were positively associated, while teacher and classmate support and satisfaction with school were negatively associated. Given the established association of psychosocial school factors with mental health, there is a need for targeted measures both at school and community level with the aim of improving social support in the school environment, reducing schoolwork burden and preventing bullying at school, potentially resulting in the overall improvement of mental health of the first grade secondary school students.

Published
2023
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33. LHC vector resonance searches in the $t\bar{t} Z$ final state

Author

Backović, Mihailo, Flacke, Thomas, Jain, Bithika, and Lee, Seung J.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, 81T99, J.2
Abstract

LHC searches for BSM resonances in $l^+ l^-, \, jj, \, t\bar{t}, \gamma \gamma$ and $VV$ final states have so far not resulted in discovery of new physics. Current results set lower limits on mass scales of new physics resonances well into the $\mathcal{O}(1)$ TeV range, assuming that the new resonance decays dominantly to a pair of Standard Model particles. While the SM pair searches are a vital probe of possible new physics, it is important to re-examine the scope of new physics scenarios probed with such final states. Scenarios where new resonances decay dominantly to final states other than SM pairs, even though well theoretically motivated, lie beyond the scope of SM pair searches. In this paper we argue that LHC searches for (vector) resonances beyond two particle final states would be useful complementary probes of new physics scenarios. As an example, we consider a class of composite Higgs models, and identify specific model parameter points where the color singlet, electrically neutral vector resonance $\rho_0$ decays dominantly not to a pair of SM particles, but to a fermionic top partner $T_{f1}$ and a top quark, with $T_{f1} \rightarrow tZ$. We show that dominant decays of $\rho_0 \rightarrow T_{f1} t$ in the context of Composite Higgs models are possible even when the decay channel to a pair of $T_{f1}$ is kinematically open. Our analysis deals with scenarios where both $m_\rho$ and $m_{T_{f1}}$ are of $\mathcal{O}(1)$ TeV, leading to highly boosted $t\bar{t}Z$ final state topologies. We show that the particular composite Higgs scenario we consider is discoverable at the LHC13 with as little as 30 fb$^{-1}$, while being allowed by other existing experimental constraints., Comment: 37 pages, 6 figures, 9 tables. v2: typos corrected, Version published in JHEP

Published
2016
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34. A comprehensive approach to dark matter studies: exploration of simplified top-philic models

Author

Arina, Chiara, Backović, Mihailo, Conte, Eric, Fuks, Benjamin, Guo, Jun, Heisig, Jan, Hespel, Benoît, Krämer, Michael, Maltoni, Fabio, Martini, Antony, Mawatari, Kentarou, Pellen, Mathieu, and Vryonidou, Eleni

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

Studies of dark matter lie at the interface of collider physics, astrophysics and cosmology. Constraining models featuring dark matter candidates entails the capability to provide accurate predictions for large sets of observables and compare them to a wide spectrum of data. We present a framework which, starting from a model lagrangian, allows one to consistently and systematically make predictions, as well as to confront those predictions with a multitude of experimental results. As an application, we consider a class of simplified dark matter models where a scalar mediator couples only to the top quark and a fermionic dark sector (i.e. the simplified top-philic dark matter model). We study in detail the complementarity of relic density, direct/indirect detection and collider searches in constraining the multi-dimensional model parameter space, and efficiently identify regions where individual approaches to dark matter detection provide the most stringent bounds. In the context of collider studies of dark matter, we point out the complementarity of LHC searches in probing different regions of the model parameter space with final states involving top quarks, photons, jets and/or missing energy. Our study of dark matter production at the LHC goes beyond the tree-level approximation and we show examples of how higher-order corrections to dark matter production processes can affect the interpretation of the experimental results., Comment: 52 pages, 23 figures

Published
2016
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35. Cornering diphoton resonance models at the LHC

Author

Backović, Mihailo, Kulkarni, Suchita, Mariotti, Alberto, Sessolo, Enrico Maria, and Spannowsky, Michael

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We explore the ability of the high luminosity LHC to test models which can explain the 750 GeV diphoton excess. We focus on a wide class of models where a 750 GeV singlet scalar couples to Standard Model gauge bosons and quarks, as well as dark matter. Including both gluon and photon fusion production mechanisms, we show that LHC searches in channels correlated with the diphoton signal will be able to probe wide classes of diphoton models with $\mathcal{L} \sim 3000\, \text{fb}^{-1}$ of data. Furthermore, models in which the scalar is a portal to the dark sector can be cornered with as little as $\mathcal{L} \sim 30\, \text{fb}^{-1}$., Comment: 21 pages, 4 figures

Published
2016
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36. A Theory of Ambulance Chasing

Author

Backović, Mihailo

Subjects
Physics - Physics and Society, Computer Science - Digital Libraries, High Energy Physics - Phenomenology, Physics - Data Analysis, Statistics and Probability
Abstract

Ambulance chasing is a common socio-scientific phenomenon in particle physics. I argue that despite the seeming complexity, it is possible to gain insight into both the qualitative and quantitative features of ambulance chasing dynamics. Compound-Poisson statistics suffices to accommodate the time evolution of the cumulative number of papers on a topic, where basic assumptions that the interest in the topic as well as the number of available ideas decrease with time appear to drive the time evolution. It follows that if the interest scales as an inverse power law in time, the cumulative number of papers on a topic is well described by a di-gamma function, with a distinct logarithmic behavior at large times. In cases where the interest decreases exponentially with time, the model predicts that the total number of papers on the topic will converge to a fixed value as time goes to infinity. I demonstrate that the two models are able to fit at least 9 specific instances of ambulance chasing in particle physics using only two free parameters. In case of the most recent ambulance chasing instance, the ATLAS {\gamma}{\gamma} excess, fits to the current data predict that the total number of papers on the topic will not exceed 310 papers by the June 1. 2016, and prior to the natural cut-off for the validity of the theory., Comment: 9 pages, 4 figures

Published
2016

37. The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance

Author

Borst, Andrew J, James, Zachary M, Zagotta, William N, Ginsberg, Mark, Rey, Felix A, DiMaio, Frank, Backovic, Marija, and Veesler, David

Subjects
Biochemistry and Cell Biology, Biological Sciences, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Cancer, Amino Acid Motifs, Angiogenesis Inhibitors, Antibodies, Monoclonal, Antigens, Antiviral Agents, Binding Sites, Bone Density Conservation Agents, Cloning, Molecular, Crystallography, X-Ray, Escherichia coli, Gene Expression, Genetic Vectors, Humans, Immunoglobulin Fab Fragments, Integrin alphaVbeta3, Ligands, Models, Molecular, Oligopeptides, Protein Binding, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Recombinant Proteins, LM609 antibody, abegrin, alpha V beta 3 integrin, etaracizumab, integrins, single-particle electron microscopy, vitaxin, Chemical Sciences, Information and Computing Sciences, Biophysics, Biological sciences, Chemical sciences
Abstract

The LM609 antibody specifically recognizes αVβ3 integrin and inhibits angiogenesis, bone resorption, and viral infections in an arginine-glycine-aspartate-independent manner. LM609 entered phase II clinical trials for the treatment of several cancers and was also used for αVβ3-targeted radioimmunotherapy. To elucidate the mechanisms of recognition and inhibition of αVβ3 integrin, we solved the structure of the LM609 antigen-binding fragment by X-ray crystallography and determined its binding affinity for αVβ3. Using single-particle electron microscopy, we show that LM609 binds at the interface between the β-propeller domain of the αV chain and the βI domain of the β3 chain, near the RGD-binding site, of all observed integrin conformational states. Integrating these data with fluorescence size-exclusion chromatography, we demonstrate that LM609 sterically hinders access of large ligands to the RGD-binding pocket, without obstructing it. This work provides a structural framework to expedite future efforts utilizing LM609 as a diagnostic or therapeutic tool.

Published
2017

39. Multiplex assays for the identification of serological signatures of SARS-CoV-2 infection: an antibody-based diagnostic and machine learning study

Author

Rosado, Jason, Pelleau, Stéphane, Cockram, Charlotte, Merkling, Sarah Hélène, Nekkab, Narimane, Demeret, Caroline, Meola, Annalisa, Kerneis, Solen, Terrier, Benjamin, Fafi-Kremer, Samira, de Seze, Jerome, Bruel, Timothée, Dejardin, François, Petres, Stéphane, Longley, Rhea, Fontanet, Arnaud, Backovic, Marija, Mueller, Ivo, and White, Michael T

Published
2021
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40. Di-photon excess illuminates Dark Matter

Author

Backovic, Mihailo, Mariotti, Alberto, and Redigolo, Diego

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We propose a simplified model of dark matter with a scalar mediator to accommodate the di-photon excess recently observed by the ATLAS and CMS collaborations. Decays of the resonance into dark matter can easily account for a relatively large width of the scalar resonance, while the magnitude of the total width combined with the constraint on dark matter relic density lead to sharp predictions on the parameters of the Dark Sector. Under the assumption of a rather large width, the model predicts a signal consistent with ~300 GeV dark matter particle in channels with large missing energy. This prediction is not yet severely bounded by LHC Run I searches and will be accessible at the LHC Run II in the jet plus missing energy channel with more luminosity. Our analysis also considers astrophysical constraints, pointing out that future direct detection experiments will be sensitive to this scenario., Comment: 23 pages, 8 figures. Added 2 figures and more discussions

Published
2015
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41. MadDM: New Dark Matter Tool in the LHC era

Author

Backovic, Mihailo, Martini, Antony, Kong, Kyoungchul, Mattelaer, Olivier, and Mohlabeng, Gopolang

Subjects
High Energy Physics - Phenomenology
Abstract

We present the updated version of MadDM, a new dark matter tool based on MadGraph5_aMC@NLO framework. New version includes direct detection capability in addition to relic abundance computation. In this article, we provide short description of the implementation of relevant effective operators and validations against existing results in literature., Comment: 4 pages. Submitted to the proceedings of PPC 2015

Published
2015
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42. Higher-order QCD predictions for dark matter production at the LHC in simplified models with s-channel mediators

Author

Backović, Mihailo, Krämer, Michael, Maltoni, Fabio, Martini, Antony, Mawatari, Kentarou, and Pellen, Mathieu

Subjects
High Energy Physics - Phenomenology
Abstract

Weakly interacting dark matter particles can be pair-produced at colliders and detected through signatures featuring missing energy in association with either QCD/EW radiation or heavy quarks. In order to constrain the mass and the couplings to standard model particles, accurate and precise predictions for production cross sections and distributions are of prime importance. In this work, we consider various simplified models with s-channel mediators. We implement such models in the FeynRules/MadGraph5_aMC@NLO framework, which allows to include higher-order QCD corrections in realistic simulations and to study their effect systematically. As a first phenomenological application, we present predictions for dark matter production in association with jets and with a top-quark pair at the LHC, at next-to-leading order accuracy in QCD, including matching/merging to parton showers. Our study shows that higher-order QCD corrections to dark matter production via s-channel mediators have a significant impact not only on total production rates, but also on shapes of distributions. We also show that the inclusion of next-to-leading order effects results in a sizeable reduction of the theoretical uncertainties., Comment: 21 pages, 14 figures, 3 tables; v2: version to appear in EPJC

Published
2015

43. Search Strategies for TeV Scale Fermionic Top Partners with Charge 2/3

Author

Backovic, Mihailo, Flacke, Thomas, Kim, Jeong Han, and Lee, Seung J.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

Searches for fermionic top partners at the TeV scale will bring forward a new final state kinematic regime and event topologies, where Run I search strategies will inevitably fail. We propose concrete search strategies for singly produced charge 2/3 fermionic top partners ($T'$) adequate for LHC Run II. Our analysis spans over all of the $T'$ decay modes ($i.e.$ $tZ$, $th$ and $Wb$) where we present detailed discussion of the search performances, signal efficiencies and backgrounds rates. Our LHC Run II search proposals utilize signatures with large missing energy and leptons, as well as jet substructure observables for tagging of boosted heavy SM states, customized $b$-tagging tactics and forward jet tagging. We analyze the prospects for discovery and exclusion of $T'$ models within the framework of partially composite quarks at the LHC Run II. Our results show that the LHC Run II has good prospects for observing $T'$ models which predict single production cross section of $\sigma_{T'} \sim 70 -140 \, (30 -65)$ fb for $M_{T'} = 1\, (1.5)$~TeV respectively with 100 fb$^{-1}$ of integrated luminosity, depending on the branching ratios of the $T'$. Similarly, we find that cross sections of $\sigma_{T'} \sim 27 -60\, (13 - 24)$ fb for $M_{T'} = 1\, (1.5)$ TeV respectively can be excluded with the same amount of data. Our results are minimally model dependent and can be applied to most $T'$ models where $\Gamma_{T'} \ll M_{T'}$., Comment: 32 pages, 11 figures, 26 tables

Published
2015
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44. Dark Matter Benchmark Models for Early LHC Run-2 Searches: Report of the ATLAS/CMS Dark Matter Forum

Author

Abercrombie, Daniel, Akchurin, Nural, Akilli, Ece, Maestre, Juan Alcaraz, Allen, Brandon, Gonzalez, Barbara Alvarez, Andrea, Jeremy, Arbey, Alexandre, Azuelos, Georges, Azzi, Patrizia, Backović, Mihailo, Bai, Yang, Banerjee, Swagato, Beacham, James, Belyaev, Alexander, Boveia, Antonio, Brennan, Amelia Jean, Buchmueller, Oliver, Buckley, Matthew R., Busoni, Giorgio, Buttignol, Michael, Cacciapaglia, Giacomo, Caputo, Regina, Carpenter, Linda, Castro, Nuno Filipe, Ceballos, Guillelmo Gomez, Cheng, Yangyang, Chou, John Paul, Gonzalez, Arely Cortes, Cowden, Chris, D'Eramo, Francesco, De Cosa, Annapaola, De Gruttola, Michele, De Roeck, Albert, De Simone, Andrea, Deandrea, Aldo, Demiragli, Zeynep, DiFranzo, Anthony, Doglioni, Caterina, Pree, Tristan du, Erbacher, Robin, Erdmann, Johannes, Fischer, Cora, Flaecher, Henning, Fox, Patrick J., Fuks, Benjamin, Genest, Marie-Helene, Gomber, Bhawna, Goudelis, Andreas, Gramling, Johanna, Gunion, John, Hahn, Kristian, Haisch, Ulrich, Harnik, Roni, Harris, Philip C., Hoepfner, Kerstin, Hoh, Siew Yan, Hsu, Dylan George, Hsu, Shih-Chieh, Iiyama, Yutaro, Ippolito, Valerio, Jacques, Thomas, Ju, Xiangyang, Kahlhoefer, Felix, Kalogeropoulos, Alexis, Kaplan, Laser Seymour, Kashif, Lashkar, Khoze, Valentin V., Khurana, Raman, Kotov, Khristian, Kovalskyi, Dmytro, Kulkarni, Suchita, Kunori, Shuichi, Kutzner, Viktor, Lee, Hyun Min, Lee, Sung-Won, Liew, Seng Pei, Lin, Tongyan, Lowette, Steven, Madar, Romain, Malik, Sarah, Maltoni, Fabio, Perez, Mario Martinez, Mattelaer, Olivier, Mawatari, Kentarou, McCabe, Christopher, Megy, Théo, Morgante, Enrico, Mrenna, Stephen, Narayanan, Siddharth M., Nelson, Andy, Novaes, Sérgio F., Padeken, Klaas Ole, Pani, Priscilla, Papucci, Michele, Paulini, Manfred, Paus, Christoph, Pazzini, Jacopo, Penning, Björn, Peskin, Michael E., Pinna, Deborah, Procura, Massimiliano, Qazi, Shamona F., Racco, Davide, Re, Emanuele, Riotto, Antonio, Rizzo, Thomas G., Roehrig, Rainer, Salek, David, Pineda, Arturo Sanchez, Sarkar, Subir, Schmidt, Alexander, Schramm, Steven Randolph, Shepherd, William, Singh, Gurpreet, Soffi, Livia, Srimanobhas, Norraphat, Sung, Kevin, Tait, Tim M. P., Theveneaux-Pelzer, Timothee, Thomas, Marc, Tosi, Mia, Trocino, Daniele, Undleeb, Sonaina, Vichi, Alessandro, Wang, Fuquan, Wang, Lian-Tao, Wang, Ren-Jie, Whallon, Nikola, Worm, Steven, Wu, Mengqing, Wu, Sau Lan, Yang, Hongtao, Yang, Yong, Yu, Shin-Shan, Zaldivar, Bryan, Zanetti, Marco, Zhang, Zhiqing, and Zucchetta, Alberto

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a repository of generator implementations. This report also addresses how to apply the Effective Field Theory formalism for collider searches and present the results of such interpretations.

Published
2015
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45. Direct Detection of Dark Matter with MadDM v.2.0

Author

Backovic, Mihailo, Kong, Kyoungchul, Martini, Antony, Mattelaer, Olivier, and Mohlabeng, Gopolang

Subjects
High Energy Physics - Phenomenology
Abstract

We present MadDM v.2.0, a numerical tool for dark matter physics in a generic model. This version is the next step towards the development of a fully automated framework for dark matter searches at the interface of collider physics, astro-physics and cosmology. It extends the capabilities of v.1.0 to perform calculations relevant to the direct detection of dark matter. These include calculations of spin-independent/spin-dependent nucleon scattering cross sections and nuclear recoil rates (as a function of both energy and angle), as well as a simplified functionality to compare the model points with existing constraints. The functionality of MadDM v.2.0 incorporates a large selection of dark matter detector materials and sizes, and simulates detector effects on the nuclear recoil signals. We validate the code in a wide range of dark matter models by comparing results from MadDM v.2.0 to the existing tools and literature., Comment: 38 pages, 8 figures, 5 tables; v2. Matches the version accepted for publication in Physics of the Dark Universe. We have improved table IV by validating the other sps points of the MSSM

Published
2015
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46. Signs of Tops from Highly Mixed Stops

Author

Backović, Mihailo, Mariotti, Alberto, and Spannowsky, Michael

Subjects
High Energy Physics - Phenomenology
Abstract

Supersymmetric extensions of the Standard Model with highly mixed squark flavours beyond minimal flavour violation provide interesting scenarios of new physics, which have so far received limited attention. We propose a calculable realization of such scenarios in models of gauge mediation augmented with an extra interaction between the messengers and the up type squark. We compute the supersymmetric spectrum and analyze the flavour physics constraints on such models. In a simplified model approach, we show that scenarios with maximal squark flavour mixing result in interesting phenomenological signatures at the LHC. We show that the model can be probed up to masses of $m_{\tilde{u}} \lesssim 950$ GeV in the single-top event topology at LHC14 with as little as 300 fb$^{-1}$. The most distinctive signature of highly mixed scenarios, the same sign positive charge di-top, can be probed to comparable squark masses at high luminosity LHC14., Comment: 36 pages, 9 figures, 8 tables. Minor changes to the conclusions section. Accepted For publication in JHEP

Published
2015

47. Towards an Understanding of the Correlations in Jet Substructure

Author

Adams, D., Arce, A., Asquith, L., Backovic, M., Barillari, T., Berta, P., Bertolini, D., Buckley, A., Butterworth, J., Toro, R. C. Camacho, Caudron, J., Chien, Y. -T., Cogan, J., Cooper, B., Curtin, D., Debenedetti, C., Dolen, J., Eklund, M., Hedri, S. El, Ellis, S. D., Embry, T., Ferencek, D., Ferrando, J., Fleischmann, S., Freytsis, M., Giulini, M., Han, Z., Hare, D., Harris, P., Hinzmann, A., Hoing, R., Hornig, A., Jankowiak, M., Johns, K., Kasieczka, G., Kogler, R., Lampl, W., Larkoski, A. J., Lee, C., Leone, R., Loch, P., Mateos, D. Lopez, Lou, H. K., Low, M., Maksimovic, P., Marchesini, I., Marzani, S., Masetti, L., McCarthy, R., Menke, S., Miller, D. W., Mishra, K., Nachman, B., Nef, P., O'Grady, F. T., Ovcharova, A., Picazio, A., Pollard, C., Potter-Landua, B., Potter, C., Rappoccio, S., Rojo, J., Rutherfoord, J., Salam, G. P., Schabinger, R. M., Schwartzman, A., Schwartz, M. D., Shuve, B., Sinervo, P., Soper, D., Corral, D. E. Sosa, Spannowsky, M., Strauss, E., Swiatlowski, M., Thaler, J., Thomas, C., Thompson, E., Tran, N. V., Tseng, J., Usai, E., Valery, L., Veatch, J., Vos, M., Waalewijn, W., Wacker, J., and Young, C.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

Over the past decade, a large number of jet substructure observables have been proposed in the literature, and explored at the LHC experiments. Such observables attempt to utilize the internal structure of jets in order to distinguish those initiated by quarks, gluons, or by boosted heavy objects, such as top quarks and W bosons. This report, originating from and motivated by the BOOST2013 workshop, presents original particle-level studies that aim to improve our understanding of the relationships between jet substructure observables, their complementarity, and their dependence on the underlying jet properties, particularly the jet radius and jet transverse momentum. This is explored in the context of quark/gluon discrimination, boosted W boson tagging and boosted top quark tagging., Comment: Report prepared by the participants of the BOOST 2013 workshop, hosted by the University of Arizona at Flagstaff, AZ, 12-16 August 2013. 54 pages, 51 figures. Version to be published in EPJC

Published
2015

49. Novel Competitive ELISA Utilizing Trimeric Spike Protein of SARS-CoV-2, Could Identify More Than RBD-RBM Specific Neutralizing Antibodies in Hybrid Sera.

Author

Eliadis, Petros, Mais, Annie, Papazisis, Alexandros, Loxa, Eleni K., Dimitriadis, Alexios, Sarrigeorgiou, Ioannis, Backovic, Marija, Agallou, Maria, Zouridakis, Marios, Karagouni, Evdokia, Lazaridis, Konstantinos, Mamalaki, Avgi, and Lymberi, Peggy

Subjects
COVID-19 pandemic, ANGIOTENSIN converting enzyme, SARS-CoV-2, IMMUNE response, TITERS
Abstract

Since the initiation of the COVID-19 pandemic, there has been a need for the development of diagnostic methods to determine the factors implicated in mounting an immune response against the virus. The most promising indicator has been suggested to be neutralizing antibodies (nAbs), which mainly block the interaction between the Spike protein (S) of SARS-CoV-2 and the host entry receptor ACE2. In this study, we aimed to develop and optimize conditions of a competitive ELISA to measure serum neutralizing titer, using a recombinant trimeric Spike protein modified to have six additional proline residues (S(6P)-HexaPro) and h-ACE2. The results of our surrogate Virus Neutralizing Assay (sVNA) were compared against the commercial sVNT (cPass, Nanjing GenScript Biotech Co., Nanjing City, China), using serially diluted sera from vaccinees, and a high correlation of ID50–90 titer values was observed between the two assays. Interestingly, when we tested and compared the neutralizing activity of sera from eleven fully vaccinated individuals who subsequently contracted COVID-19 (hybrid sera), we recorded a moderate correlation between the two assays, while higher sera neutralizing titers were measured with sVNA. Our data indicated that the sVNA, as a more biologically relevant model assay that paired the trimeric S(6P) with ACE2, instead of the isolated RBD-ACE2 pairing cPass test, could identify nAbs other than the RBD-RBM specific ones. [ABSTRACT FROM AUTHOR]

Published
2024
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