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413 results on '"Baden, Howard P."'

11. Detection of substrates of keratinocyte transglutaminase in vitro and in vivo using a monoclonal antibody to dansylcadaverine

Author

Kvedar, Joseph C., Pion, Ira A., Bilodeau, Elise B., Baden, Howard P., and Greco, Mary Ann

Subjects
Keratinocytes -- Research, Transglutaminases -- Research, Monoclonal antibody probes -- Usage, Biological sciences, Chemistry
Abstract

Monoclonal antibodies to dansylcadaverine were used in localization of transglutaminase activity in tissue and identification of in vivo substrates in epidermal extracts. Putative transglutaminase substrates were demonstrated using western blot analysis and their activities were measured by enzyme-linked immunosorbent assay. The cellular periphery in the upper spinous and granular cell layers of the epidermis were recognized as sites of enzyme activity. Moreover, the in vitro and in vivo substrates identified were similar.

Published
1992

19. Yellow nail syndrome

Author

DeCoste, Susan D., Imber, Michael J., and Baden, Howard P.

Subjects
Nails (Anatomy) -- Abnormalities, Health
Abstract

Yellow fingernails, or yellow nail syndrome, are known to be associated with lymphedema (accumulation of lymphatic fluid in tissues, leading to swelling), but the condition's actual causes are not known. It occurs in people with pleural effusions (fluid in the pleural cavity), chronic bronchiectasis (destruction of the bronchial tree), and chronic sinusitis, as well as malignancies, thyroid disease, rheumatoid arthritis, and deficiencies of the immune system. Two patients in whom the symptom resolved are discussed, of particular interest because their underlying disorders had not disappeared. Such findings cast doubt on the belief that yellow nail syndrome is the result of systemic disease. One patient had had yellow, thickened nails on toes and fingers for three years. She had sinusitis, lymphedema, and swelling of the legs. Three months after nail cultures were taken, the nails near the cuticle looked normal, and they continued to grow normally. Her other symptoms did not change. The second patient had had bronchitis and sinusitis for two years, with yellow nails; these, too, began to grow normally without relief of other symptoms. Biopsies from the nail bed of the first patient showed growth of thick, fibrous tissue, with distensible channels lined with endothelium throughout. Progressive hardening (sclerosis) of the nail bed may have caused lymphatic obstruction, and led to yellow nail syndrome as a result of mechanisms unknown. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

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