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11. Escape to the Shelter.

Author

Badenock, Kathy

Subjects
SINGLE-parent families, BODY odor, YOUNG adults, BODY temperature, WORKING mothers
Published
2024

13. tert-Butyl 2,3-dihydro-1H-cyclopenta[b]indole-4-carboxylate

Author

Jason A. Jordon, Jeanese C. Badenock, Gordon W. Gribble, Manpreet Kaur, and Jerry P. Jasinski

Subjects
crystal structure, π–π stacking interactions, C—H...π interactions, mirror plane, Crystallography, QD901-999
Abstract

In the title molecule, C16H19NO2, all the non-hydrogen atoms except two of the C atoms of the tert-butyl group lie on a crystallographic mirror plane. No classical hydrogen bonds are observed. The crystal packing is influenced by weak π–π and C—H...π interactions.

Published
2016
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18. 3,3-Dimethyl-1,2,3,4-tetrahydrocyclopenta[b]indole-1,2-dione (bruceolline E)

Author

Jason A. Jordon, Jeanese C. Badenock, Gordon W. Gribble, Jerry P. Jasinski, and James A. Golen

Subjects
Crystallography, QD901-999
Abstract

The title compound, C13H11NO2, crystallizes with two molecules in the asymmetric unit. The crystal packing is stabilized by N—H...O hydrogen bonds, which link the molecules into chains along [10-1], and weak C—H...O interactions.

Published
2012
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19. The Synthesis of (±)-1,2,3,4,6,7,12,12b-Octahydroindolo[2,3-a]quinolizine from Tryptophan and Dihydropyran

Author

Gordon W. Gribble and Jeanese C. Badenock

Subjects
chemistry.chemical_compound, Quinolizidine, chemistry, 010405 organic chemistry, Dihydropyran, Stereochemistry, Organic Chemistry, Tryptophan, Quinolizine, Amine gas treating, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences
Abstract

Indolo[2,3-a]quinolizidine 1 (Scheme 1) has an interesting history. First synthesized by Keufer1 in 1950, this tetracyclic amine was subsequently prepared by several others,2–7 only later to be dis...

Published
2018
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21. 4-Phenylsulfonyl-2-(p-tolylsulfonyl)-1H,8H-pyrrolo[2,3-b]indole

Author

Jeanese C. Badenock, Jason A. Jordan, Erin T. Pelkey, Gordon W. Gribble, and Jerry P. Jasinski

Subjects
Crystallography, QD901-999
Abstract

The title compound, C23H18N2O4S2, contains a pyrrolo group fused onto the plane of an indole ring with phenylsulfonyl and p-toluenesulfonyl groups bonded to the indole and pyrrolo rings. The angles between the mean planes of the pyrrolo-indole ring and the phenylsulfonyl and p-toluenesulfonyl rings are 73.7 (6) and 80.6 (0)°, respectively. The dihedral angle between the mean planes of the two benzene rings is 78.7 (4)°. In the crystal, both classical N—H...O and non-classical C—H...O intermolecular hydrogen-bonding interactions are observed, as well as weak π–π interactions [centroid–centroid distances = 3.6258 (8) and 3.9298 (8) Å], which contribute to the stability of the packing.

Published
2010
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29. Synthetic approaches toward the marine alkaloid prenostodione

Author

Jason A. Jordan, Jeanese C. Badenock, and Gordon W. Gribble

Subjects
Indole test, Benzaldehyde, chemistry.chemical_compound, chemistry, Alkaloid, Organic Chemistry, Drug Discovery, Prenostodione, Organic chemistry, Ring (chemistry), Biochemistry, Saponification
Abstract

An efficient synthesis of the core of prenostodione (3) is described herein featuring the base condensation of BOC-protected indole diesters 21 and 24 with p-methoxybenzaldehyde (22) and 4-[(t-butyldimethylsilyl)oxy]benzaldehyde (26). Attempts at selective saponification of the resultant diesters yielded isoprenostodione (3a) bearing the ester functionality at the C-3 position of the indole ring.

Published
2013
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30. tert-Butyl 2,3-dihydro-1H-cyclopenta[b]indole-4-carboxylate

Author

Manpreet Kaur, Gordon W. Gribble, Jerry P. Jasinski, Jeanese C. Badenock, and Jason A. Jordon

Subjects
Indole test, Tert butyl, crystal structure, Chemistry, Hydrogen bond, General Medicine, Crystal structure, 010402 general chemistry, 010403 inorganic & nuclear chemistry, 01 natural sciences, 0104 chemical sciences, Crystal, Crystallography, C—H...π interactions, Group (periodic table), π–π stacking interactions, mirror plane, lcsh:QD901-999, Physics::Atomic Physics, lcsh:Crystallography, Physics::Chemical Physics, Mirror plane
Abstract

In the title molecule, C16H19NO2, all the non-hydrogen atoms except two of the C atoms of thetert-butyl group lie on a crystallographic mirror plane. No classical hydrogen bonds are observed. The crystal packing is influenced by weak π–π and C—H...π interactions.

Published
2016

31. A concise total synthesis of bruceolline E

Author

Gordon W. Gribble, Jason A. Jordan, and Jeanese C. Badenock

Subjects
Indole test, Tandem, Organic Chemistry, chemistry.chemical_element, Total synthesis, Biochemistry, Acylation, chemistry.chemical_compound, chemistry, Yield (chemistry), Drug Discovery, Organic chemistry, Bruceolline E, Selenium, Acrylic acid
Abstract

An efficient synthesis of bruceolline E was completed in three steps from the known ethyl indole-1-carboxylate ( 9d ) in 60% overall yield, via a tandem acylation/Nazarov cyclization with 3,3-dimethyl acrylic acid followed by selenium dioxide oxidation to install the α-diketone functionality.

Published
2011
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34. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

Author

W Beeston, N P R Brown, I D A Peacock, J Wain, E A Knowles, L Armistead, P Raval, A Hudson, Andrew D. Wilson, J Barrett, P England, S Clarke, L Bower, A J Tucker, R Gregory, B Kilgallon, L Kennedy, R Coster, W Wheatcroft, R J Seaman, H Davenport, M H Charlton, C R Tidy, B J Gould, Alex D. Wright, C Rose, Clyne, P Parker, C Roxburgh, S Kumar, A Glover, A B Atkinson, A Badenock, G Frost, M Fernandez, X M P Petrie, S J Evans, J Clarke, K Williams, S Gyde, R Price, M C Doddridge, Sidney C. Smith, A S Spathis, C Searnark, Chris Wallace, Hammersley, S L Franklin, N Vaghela, S Rainbow, R C Temple, P Musk, R Parker, Katoulis, A Olukoga, Gpr Archbold, M Roseblade, Aci Shearer, H Lampard, Hayes, M Flatman, J Rutherford, K Quested, C Eagle, R W Newton, Josh Smith, M Burden, R Paisey, S Kilby, P Harvey, S Gorick, L M Wong, J Grenfell, P G Hill, C Warren, A Prest, P Raniga, Hadden, M Richard, R Wilcocks, N A Levi, I O'Connell, J Stockman, Richard B Paisey, I Robinson, S L Palmer, H Cole, E Duckworth, E Marriot, R A Christie, I Draisey, M Bond, B Abuaisha, A C Burden, B Martin, M Sleightholm, L E Murchison, H McDonald, B Rice, C Davis, S King, G Wallace, A M Culbert, D Humphriss, E M Sellen, S Higgins, N J C Culverwell, M E Nanson, J M Tyrell, J. C. Frost, S Church, C Parkes, N Walravens, J Burns, A J Fox, Tim Dornan, J Singer, R Harper, K Myers, R J Young, N Webb, H Tennet, F Garrett, A J M Boulton, C Pym, C Munroe, K Stanton-King, S Mason, H Mungall, D McDowell, J Piper, P Rocket, K Waring, M J Lyall, J Church, A Farrow, M Dumskyj, J Booker, L Dick, J McVittie, C Merle, Jennifer White, George L. King, K Whitfield, M Copeland, H A Davison, M Booth, Angela C. Shore, A Dornhurst, M Gibson, M Hoyle, J Curwell, S Martin, P M Bell, A Higham, C Hegan, S McDougal, D J Brown, K McHardy, N Hein, R T Jung, E M Kohner, J Sunter, S Hulland, J Hogg, W Maddison, N Patterson, R W Henry, D W Pearson, C Yeo, K Palmer, D Donnelly, N Waugh, K Breislin, R Chapman, D J Wheatcroft, J Sherwell, M Eckert, J M Roland, A J M Davidson, M Roshan, J Steemson, Meredith C. Foster, C Sereviratne, D Walmsley, G Shawcross, E Truscott, M J Williams, M Stowers, K. M. MacLeod, B A Barrow, J S Yudkin, K L Wright, M Rammell, E Thomson, D Clark, E Christie, K Alibhai, A Ellingford, Jonathan C. Levy, M E J Lean, J Nolan, R H Greenwood, M Bradbury, J M Stowers, J Holmes, L Cook, S Nesbitt, J Youens, J L Barron, P Poon, P Strugnell, L M James, M J Denholm, L J Borthwick, P M Brown, A Ryle, F Abouaesha, Featherston, I Richardson, J Graham, Graham Dunn, A M Robertson, G Taylor, C Sherriff, J Grey, Uspds Grp, J Peacock, McCance, S Hyer, P Griffin, E Mehmed, S Walji, S Rayton, P Park, L Leighton, W Cowan, James G. Wilson, B Chakrabarti, Christopher E. Cox, Stearne, N J Bell, A Smyth-Osbourne, H M Coghill, K Jones, F Johnson, Ellen Green, M C Holloway, B P S Connolly, Je Tooke, R J W Thompson, S Townsend, R S Spivey, S Elliott, H Petrie, A J James, S Forrester, Richard Rose, S MacFarlane, A H E Brunt, C Fox, P Sharp, G Vanterpool, and S J Wilson

Subjects
medicine.medical_specialty, business.industry, United Kingdom Prospective Diabetes Study, General Engineering, General Medicine, Diabetic retinopathy, Type 2 diabetes, Diabetic angiopathy, medicine.disease, Mean blood pressure, Blood pressure, Internal medicine, Diabetes mellitus, Cardiology, General Earth and Planetary Sciences, Medicine, Myocardial infarction, business, General Environmental Science
Abstract

OBJECTIVE: To determine whether tight control of blood pressure prevents macrovascular and microvascular complications in patients with type 2 diabetes. DESIGN: Randomised controlled trial comparing tight control of blood pressure aiming at a blood pressure of

Published
1998
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35. Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes: UKPDS 40

Author

Stearne, MR, Palmer, SL, Hammersley, MS, Franklin, SL, Spivey, RS, Levy, JC, Tidy, CR, Bell, NJ, Steemson, J, Barrow, BA, Coster, R, Waring, K, Nolan, L, Truscott, E, Walravens, N, Cook, L, Lampard, H, Merle, C, Parker, P, McVittie, J, Draisey, I, Murchison, LE, Brunt, AHE, Williams, MJ, Pearson, DW, Petrie, XMP, Lean, MEJ, Walmsley, D, Lyall, F, Christie, E, Church, J, Thomson, E, Farrow, A, Stowers, JM, Stowers, M, McHardy, K, Patterson, N, Wright, AD, Levi, NA, Shearer, ACI, Thompson, RJW, Taylor, G, Rayton, S, Bradbury, M, Glover, A, Smyth-Osbourne, A, Parkes, C, Graham, J, England, P, Gyde, S, Eagle, C, Chakrabarti, B, Smith, J, Sherwell, J, Kohner, EM, Dornhorst, A, Doddridge, MC, Dumskyj, M, Walji, S, Sharp, P, Sleightholm, M, Vanterpool, G, Rose, C, Frost, G, Roseblade, M, Elliott, S, Forrester, S, Foster, M, Myers, K, Chapman, R, Hayes, JR, Henry, RW, Featherston, MS, Archbold, GPR, Copeland, M, Harper, R, Richardson, I, Martin, S, Davison, HA, Hadden, DR, Kennedy, L, Atkinson, AB, Culbert, AM, Hegan, C, Tennet, H, Webb, N, Robinson, I, Holmes, J, Bell, PM, McCance, DR, Rutherford, J, Nesbitt, S, Spathis, AS, Hyer, S, Nanson, ME, James, LM, Tyrell, JM, Davis, C, Strugnell, P, Booth, M, Petrie, H, Clark, D, Rice, B, Hulland, S, Barron, JL, Yudkin, JS, Gould, BJ, Singer, J, Badenock, A, Eckert, M, Alibhai, K, Marriot, E, Cox, C, Price, R, Fernandez, M, Ryle, A, Clarke, S, Wallace, G, Mehmed, E, MacFarlane, S, Greenwood, RH, Wilson, J, Denholm, MJ, Temple, RC, Whitfield, K, Johnson, F, Munroe, C, Gorick, S, Duckworth, E, Flatman, M, Rainbow, S, Borthwick, LJ, Wheatcroft, DJ, Seaman, RJ, Christie, RA, Wheatcroft, W, Musk, P, White, J, McDougal, S, Bond, M, Raniga, P, Newton, RW, Jung, RT, Roxburgh, C, Kilgallon, B, Dick, L, Waugh, N, Kilby, S, Ellington, A, Burns, J, Fox, CV, Holloway, MC, Coghill, HM, Hein, N, Fox, A, Cowan, W, Richard, M, Quested, K, Evans, SJ, Paisey, RB, Brown, NPR, Tucker, AJ, Paisey, R, Garrett, F, Hogg, J, Park, P, Williams, K, Harvey, P, Wilcocks, R, Mason, S, Frost, J, Warren, C, Rocket, P, Bower, L, Roland, JM, Brown, DJ, Youens, J, Stanton-King, K, Mungall, H, Ball, V, Maddison, W, Donnelly, D, King, S, Griffin, P, Smith, S, Church, S, Dunn, G, Wilson, A, Palmer, K, Brown, PM, Humphriss, D, Davidson, AJM, Rose, R, Armistead, L, Townsend, S, Poon, P, Peacock, IDA, Culverwell, NJC, Charlton, MH, Connolly, BPS, Peacock, J, Barrett, J, Wain, J, Beeston, W, King, G, Hill, PG, Boulton, AJM, Robertson, AM, Katoulis, V, Olukoga, A, McDonald, H, Kumar, S, Abouaesha, F, Abuaisha, B, Knowles, EA, Higgins, S, Booker, J, Sunter, J, Breislin, K, Parker, R, Raval, P, Curwell, J, Davenport, J, Shawcross, G, Prest, A, Grey, J, Cole, H, Sereviratne, C, Young, RJ, Dornan, TL, Clyne, JR, Gibson, M, O'Connell, I, Wong, LM, Wilson, SJ, Wright, KL, Wallace, C, McDowell, D, Burden, AC, Sellen, EM, Gregory, R, Roshan, M, Vaghela, N, Burden, M, Sherriff, C, Clarke, J, Grenfell, J, Tooke, JE, MacLeod, K, Searnark, C, Rammell, M, Pym, C, Stockman, J, Yeo, C, Piper, J, Leighton, L, Green, E, Hoyle, M, Jones, K, Hudson, A, James, AJ, Shore, A, Higham, A, Martin, B, and Grp, UKPDS

Subjects
General Engineering, HC Economic History and Conditions, General Earth and Planetary Sciences, General Medicine, R Medicine (General), General Environmental Science
Abstract

Objectives: To estimate the economic efficiency of tight blood pressure control, with angiotensin converting enzyme inhibitors or beta blockers, compared with less tight control in hypertensive patients with type 2 diabetes. Design: Cost effectiveness analysis incorporating within trial analysis and estimation of impact on life expectancy through use of the within trial hazards of reaching a defined clinical end point. Use of resources driven by trial protocol and use of resources in standard clinical practice were both considered. Setting: 20 hospital based clinics in England, Scotland, and Northern Ireland. Subjects: 1148 hypertensive patients with type 2 diabetes from UK prospective diabetes study randomised to tight control of blood pressure (n=758) or less tight control (n=390). Main outcome measure: Cost effectiveness ratios based on (a) use of healthcare resources associated with tight control and less tight control and treatment of complications and (b) within trial time free from diabetes related end points, and life years gained. Results: Based on use of resources driven by trial protocol, the incremental cost effectiveness of tight control compared with less tight control was cost saving. Based on use of resources in standard clinical practice, incremental cost per extra year free from end points amounted to £1049 (costs and effects discounted at 6% per year) and £434 (costs discounted at 6% per year and effects not discounted). The incremental cost per life year gained was £720 (costs and effects discounted at 6% per year) and £291 (costs discounted at 6% per year and effects not discounted). Conclusions: Tight control of blood pressure in hypertensive patients with type 2 diabetes substantially reduced the cost of complications, increased the interval without complications and survival, and had a cost effectiveness ratio that compares favourably with many accepted healthcare programmes.

Published
1998
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36. ChemInform Abstract: A Short, Protecting Group-Free Total Synthesis of Bruceollines D, E, and J

Author

Gordon W. Gribble, Ilene L. Green, Jeanese C. Badenock, and Justin M. Lopchuk

Subjects
Stereochemistry, Chemistry, Enantioselective synthesis, Bruceolline E, Total synthesis, General Medicine, Enantiomer, Protecting group, Bruceolline J
Abstract

A short, protecting group-free total synthesis of bruceollines D, E, and J has been achieved. The enantioselective reduction of bruceolline E with β-chlorodiisopinocampheylborane delivers both the natural and unnatural enantiomers of bruceolline J in excellent yields and enantioselectivities. Reduction with baker’s yeast and sucrose was shown to provide the unnatural enantiomer of bruceolline J in 98% ee.

Published
2013
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37. ChemInform Abstract: Radical Reactions of Indole

Author

Jeanese C. Badenock

Subjects
Indole test, Chemistry, General Medicine, Combinatorial chemistry
Abstract

Radical additions and cyclization reactions continue to play a dominant role in the chemistry of indoles, generating, in many cases, fused derivatives via cascade sequences.

Published
2011
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38. 4-Phenyl-sulfon-yl-2-(p-tolyl-sulfon-yl)-1H,8H-pyrrolo-[2,3-b]indole

Author

Erin T. Pelkey, Jerry P. Jasinski, Jason A. Jordan, Gordon W. Gribble, and Jeanese C. Badenock

Subjects
Indole test, 010405 organic chemistry, General Chemistry, Dihedral angle, 010402 general chemistry, Condensed Matter Physics, Ring (chemistry), 01 natural sciences, Organic Papers, 3. Good health, 0104 chemical sciences, lcsh:Chemistry, chemistry.chemical_compound, Crystallography, chemistry, lcsh:QD1-999, General Materials Science, Benzene
Abstract

The title compound, C23H18N2O4S2, contains a pyrrolo group fused onto the plane of an indole ring with phenylsulfonyl and p-toluenesulfonyl groups bonded to the indole and pyrrolo rings. The angles between the mean planes of the pyrrolo-indole ring and the phenylsulfonyl and p-toluenesulfonyl rings are 73.7 (6) and 80.6 (0)°, respectively. The dihedral angle between the mean planes of the two benzene rings is 78.7 (4)°. In the crystal, both classical N—H...O and non-classical C—H...O intermolecular hydrogen-bonding interactions are observed, as well as weak π–π interactions [centroid–centroid distances = 3.6258 (8) and 3.9298 (8) Å], which contribute to the stability of the packing.

Published
2010

39. ChemInform Abstract: A Novel Radical Cyclization of 2-Bromoindoles. Synthesis of Hexahydropyrrolo[3,4-b]indoles

Author

Heidi L. Fraser, Gordon W. Gribble, and Jeanese C. Badenock

Subjects
Indole test, Stereochemistry, Chemistry, General Medicine, Radical cyclization
Abstract

Hexahydropyrrolo[3,4-b]indoles 6, 10, and 13 are obtained from 2-bromo-3-carboxamides 5, 9, and 12, respectively, by a 1,5-radical translocation process followed by 5-endo-trig cyclization to the indole C-2 position.

Published
2010
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41. Azepinyl 2-bromo-1-methyl-1H-indol-3-yl ketone

Author

Heidi L. Fraser, Gordon W. Gribble, Jerry P. Jasinski, and Jeanese C. Badenock

Subjects
chemistry.chemical_classification, Indole test, Steric effects, Ketone, Double bond, General Chemistry, Crystal structure, Condensed Matter Physics, Ring (chemistry), Medicinal chemistry, chemistry.chemical_compound, chemistry, Azepane, Amide, General Materials Science
Abstract

The crystal structure of the title compound, C16H19BrN2O, reveals that the amide group is twisted out of π-conjugation with the indole double bond due to steric hindrance by the Br atom. The azepane ring adopts a twist-chair conformation.

Published
2007
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42. 2-Bromo-N-tert-butyl-N,1-dimethyl-1H-indole-3-carboxamide

Author

Jerry P. Jasinski, Gordon W. Gribble, Jeanese C. Badenock, and Heidi L. Fraser

Subjects
Indole test, Steric effects, Tert butyl, chemistry.chemical_classification, Double bond, medicine.drug_class, Stereochemistry, Carboxamide, General Chemistry, Crystal structure, Condensed Matter Physics, chemistry.chemical_compound, chemistry, Amide, medicine, General Materials Science, Pyrrole
Abstract

The crystal structure of the title compound, C15H19BrN2O, reveals that the amide group is twisted out of π-conjugation with the pyrrole double bond due to steric hindrance by the Br atom.

Published
2007
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43. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group

Author

Stearne, MR, Palmer, SL, Hammersley, MS, Franklin, SL, Spivey, RS, Levy, JC, Tidy, CR, Bell, NJ, Steemson, J, Barrow, BA, Coster, R, Waring, K, Nolan, J, Truscott, E, Walravens, N, Cook, L, Lampard, H, Merle, C, Parker, P, McVittie, J, Draisey, I, Murchison, LE, Brunt, AHE, Williams, MJ, Pearson, DW, Petrie, XMP, Lean, MEJ, Walmsley, D, Lyall, MJ, Christie, E, Church, J, Thomson, E, Farrow, A, Stowers, JM, Stowers, M, McHardy, K, Patterson, N, Wright, AD, Levi, NA, Shearer, ACI, Thompson, RJW, Taylor, G, Rayton, S, Bradbury, M, Glover, A, Smyth-Osbourne, A, Parkes, C, Graham, J, England, P, Gyde, S, Eagle, C, Chakrabarti, B, Smith, J, Sherwell, J, Kohner, EM, Dornhurst, A, Doddridge, MC, Dumskyj, M, Walji, S, Sharp, P, Sleightholm, M, Vanterpool, G, Rose, C, Frost, G, Roseblade, M, Elliott, S, Forrester, S, Foster, M, Myers, K, Chapman, R, Hayes, JR, Henry, RW, Featherston, MS, Archbold, GPR, Copeland, M, Harper, R, Richardson, I, Martin, S, Davison, HA, Hadden, DR, Kennedy, L, Atkinson, AB, Culbert, AM, Hegan, C, Tennet, H, Webb, N, Robinson, I, Holmes, J, Bell, PM, McCance, DR, Rutherford, J, Nesbitt, S, Spathis, AS, Hyer, S, Nanson, ME, James, LM, Tyrell, JM, Davis, C, Strugnell, P, Booth, M, Petrie, H, Clark, D, Rice, B, Hulland, S, Barron, JL, Yudkin, JS, Gould, BJ, Singer, J, Badenock, A, Eckert, M, Alibhai, K, Marriot, E, Cox, C, Price, R, Fernandez, M, Ryle, A, Clarke, S, Wallace, G, Mehmed, E, MacFarlane, S, Greenwood, RH, Wilson, J, Denholm, MJ, Temple, RC, Whitfield, K, Johnson, F, Munroe, C, Gorick, S, Duckworth, E, Flatman, M, Rainbow, S, Borthwick, LJ, Wheatcroft, DJ, Seaman, RJ, Christie, RA, Wheatcroft, W, Musk, P, White, J, McDougal, S, Bond, M, Raniga, P, Newton, RW, Jung, RT, Roxburgh, C, Kilgallon, B, Dick, L, Waugh, N, Kilby, S, Ellingford, A, Burns, J, Fox, CV, Holloway, MC, Coghill, HM, Hein, N, Fox, A, Cowan, W, Richard, M, Quested, K, Evans, SJ, Paisey, RB, Brown, NPR, Tucker, AJ, Paisey, R, Garrett, F, Hogg, J, Park, P, Williams, K, Harvey, P, Wilcocks, R, Mason, S, Frost, J, Warren, C, Rocket, P, Bower, L, Roland, JM, Brown, DJ, Youens, J, Stanton-King, K, Mungall, H, Ball, V, Maddison, W, Donnelly, D, King, S, Griffin, P, Smith, S, Church, S, Dunn, G, Wilson, A, Palmer, K, Brown, PM, Humphriss, D, Davidson, AJM, Rose, R, Armistead, L, Townsend, S, Poon, P, Peacock, IDA, Culverwell, NJC, Charlton, MH, Connolly, BPS, Peacock, J, Barrett, J, Wain, J, Beeston, W, King, G, Hill, PG, Boulton, AJM, Robertson, AM, Katoulis, V, Olukoga, A, McDonald, H, Kumar, S, Abouaesha, F, Abuaisha, B, Knowles, EA, Higgins, S, Booker, J, Sunter, J, Breislin, K, Parker, R, Raval, P, Curwell, J, Davenport, H, Shawcross, G, Prest, A, Grey, J, Cole, H, Sereviratne, C, Young, RJ, Dornan, TL, Clyne, JR, Gibson, M, O'Connell, I, Wong, LM, Wilson, SJ, Wright, KL, Wallace, C, McDowell, D, Burden, AC, Sellen, EM, Gregory, R, Roshan, M, Vaghela, N, Burden, M, Sherriff, C, Clarke, J, Grenfell, J, Tooke, JE, MacLeod, K, Searnark, C, Rammell, M, Pym, C, Stockman, J, Yeo, C, Piper, J, Leighton, L, Green, E, Hoyle, M, Jones, K, Hudson, A, James, AJ, Shore, A, Higham, A, Martin, B, and Grp, USPDS

Abstract

OBJECTIVE: To determine whether tight control of blood pressure prevents macrovascular and microvascular complications in patients with type 2 diabetes. DESIGN: Randomised controlled trial comparing tight control of blood pressure aiming at a blood pressure of

Published
1998

44. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. UK Prospective Diabetes Study Group

Author

Stearne, MR, Palmer, SL, Hammersley, MS, Franklin, SL, Spivey, RS, Levy, JC, Tidy, CR, Bell, NJ, Steemson, J, Barrow, BA, Coster, R, Waring, K, Nolan, L, Truscott, E, Walravens, N, Cook, BL, Lampard, H, Merle, C, Parker, P, McVittie, J, Draisey, I, Murchison, LE, Brunt, AHE, Williams, MJ, Pearson, DW, Petrie, XMP, Lean, MEJ, Walmsley, D, Lyall, F, Christie, E, Church, J, Thomson, E, Farrow, A, Stowers, JM, Stowers, M, McHardy, K, Patterson, N, Wright, AD, Levi, NA, Shearer, AGI, Thompson, RJW, Taylor, G, Rayton, S, Bradbury, M, Glover, A, Smyth-Osbourne, A, Parkes, C, Graham, J, England, P, Gyde, S, Eagle, C, Chakrabarti, B, Smith, J, Sherwell, J, Kohner, EM, Dornhorst, A, Doddridge, MC, Dumskyj, M, Walji, S, Sharp, P, Sleightholm, M, Vanterpool, G, Rose, C, Frost, G, Roseblade, M, Elliott, S, Forrester, S, Foster, M, Myers, K, Chapman, R, Hayes, JR, Henry, TW, Featherston, MS, Archbold, GPR, Copeland, M, Harper, R, Richardson, I, Martin, S, Davison, HA, Hadden, DR, Kennedy, L, Atkinson, AB, Culbert, AM, Hegan, C, Tennet, H, Webb, N, Robinson, I, Holmes, J, Bell, PM, McCance, DR, Rutherford, J, Nesbitt, S, Spathis, AS, Hyer, S, Nanson, ME, James, JM, Tyrell, JM, Davis, C, Strugnell, P, Booth, M, Petrie, H, Clark, D, Rice, B, Hulland, S, Barron, JL, Yudkin, JS, Gould, BJ, Singer, J, Badenock, A, Eckert, M, Alibhai, K, Marriot, E, Cox, C, Price, R, Fernandez, M, Ryle, A, Clarke, S, Wallace, G, Mehmed, E, MacFarlane, S, Greenwood, RH, Wilson, J, Denholm, MJ, Temple, RC, Whitfield, K, Johnson, F, Munroe, C, Gorick, S, Duckworth, E, Flatman, M, Rainbow, S, Borthwick, LJ, Wheatcroft, DJ, Seaman, RJ, Christie, RA, Wheatcroft, W, Musk, P, White, J, McDougal, S, Bond, M, Raniga, P, Newton, RW, Jung, RT, Roxburgh, C, Kilgallon, B, Dick, L, Waugh, N, Kilby, S, Ellingford, A, Burns, J, Fox, CV, Holloway, MC, Coghill, HM, Hein, N, Fox, A, Cowan, W, Richard, M, Quested, K, Evans, SJ, Paisey, RB, Brown, NPR, Tucker, AJ, Paisey, R, Garrett, F, Hogg, J, Park, P, Williams, K, Harvey, P, Wilcocks, R, Mason, S, Frost, J, Warren, C, Rocket, P, Bower, L, Roland, JM, Brown, DJ, Youens, J, Stanton-King, K, Mungall, H, Ball, V, Maddison, W, Donnelly, D, King, S, Griffin, P, Smith, S, Church, S, Dunn, G, Wilson, A, Palmer, K, Brown, PM, Humphriss, D, Davidson, AJM, Rose, R, Armistead, L, Townsend, S, Poon, P, Peacock, IDA, Culverwell, NJC, Charlton, MH, Connolly, BPS, Peacock, J, Barrett, J, Wain, J, Beeston, W, King, G, Hill, PG, Boulton, AJM, Robertson, AM, Katoulis, V, Olukoga, A, McDonald, H, Kumar, S, Abouaesha, F, Abuaisha, B, Knowles, EA, Higgins, S, Booker, J, Sunter, J, Breislin, K, Parker, R, Raval, P, Curwell, J, Davenport, H, Shawcross, G, Prest, A, Grey, J, Cole, H, Sereviratne, C, Young, RJ, Dornan, TL, Clyne, JR, Gibson, M, O'Connell, I, Wong, LM, Wilson, SJ, Wright, KL, Wallace, C, McDowell, D, Burden, AC, Sellen, EM, Gregory, R, Roshan, M, Vaghela, N, Burden, M, Sherriff, C, Clarke, J, Grenfell, J, Tooke, JE, MacLeod, K, Searnark, C, Rammell, M, Pym, C, Stockman, J, Yeo, C, Piper, J, Leighton, L, Green, E, Hoyle, M, Jones, K, Hudson, A, James, AJ, Shore, A, Higham, A, Martin, B, and Grp, USPDS

Subjects
cardiovascular diseases, circulatory and respiratory physiology
Abstract

OBJECTIVE: To determine whether tight control of blood pressure with either a beta blocker or an angiotensin converting enzyme inhibitor has a specific advantage or disadvantage in preventing the macrovascular and microvascular complications of type 2 diabetes. DESIGN: Randomised controlled trial comparing an angiotensin converting enzyme inhibitor (captopril) with a beta blocker (atenolol) in patients with type 2 diabetes aiming at a blood pressure of =300 mg/l (5% and 9%). The proportion of patients with hypoglycaemic attacks was not different between groups, but mean weight gain in the atenolol group was greater (3.4 kg v 1.6 kg). CONCLUSION: Blood pressure lowering with captopril or atenolol was similarly effective in reducing the incidence of diabetic complications. This study provided no evidence that either drug has any specific beneficial or deleterious effect, suggesting that blood pressure reduction in itself may be more important than the treatment used.

Published
1998

45. 5-Methyl-5bβ,6,7,8,9,11aα-hexahydro-5H-indolizino[1,2-b]indol-11(5aαH)-one

Author

Jerry P. Jasinski, Heidi L. Fraser, Gordon W. Gribble, and Jeanese C. Badenock

Subjects
Indole test, Stereochemistry, Chemistry, General Materials Science, General Chemistry, Condensed Matter Physics, HEXA, Ring (chemistry)
Abstract

The title compound, C5H18N2O, reveals a cis–trans stereochemistry for this rare example of the 5H-indolizino[1,2-b]indole ring system.

Published
2006
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