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3. Impact of an antimicrobial stewardship program indicator on the appropriateness of the empiric antibiotic treatment of urinary source Escherichia coli bacteraemia

Author

Blanco, Naiara Villalba, Vidal, Rafel Pérez, Fernández, Francisco José Vargas-Machuca, de Gracia García Ramírez, Mª, Castro, Ivan Javier, Serra, Natàlia Juan, Satorra, Rosa Maria Morera, Martorell, Sara Oduber, Huerta, Eduardo Sáez, Carrascosa, Montserrat, Soriano, Ludivina Ibañez, Smithson, Alex, Miserachs, Nuria, Blancas, David, Alonso-Tarrés, Carles, Ayuso, Elisabet Farré, González, Maria Priegue, de Ciriza Villacampa, Carmen Pérez, Fernández, María Dolores García, Martins, Marlene Àlvarez, del Río Pérez, Oscar, Riera, Ester Sanfeliu, Bertomeu, Manel Panisello, Flores, Angels García, González, Laura Linares, Pujol, Ester Comellas i, Matias, Guillem Vila, Adell, Claudia Miralles, Marcual, Jaume Llaberia, Sibat, Anna Martinez, Flotats, Elisenda, Roldan, Francina Riu, Martinez, Lorena Gaviria, de Gamarra Martínez, Edurne Fernández, Solchaga, Virginia Pomar, Luque, M. Fernanda Solano, Barque, M. Pilar Barrufet, Nicolas, Elisabeth Mauri, Fidalgo, Arantzazu Mera, Bertran, Nuria Torrellas, Gomila-Grange, Aina, Blasi, Oriol Gasch, Badia, Ester Dorca, Santamaria, Marta Andrés, Pérez-Moreno, Mar Olga, Pallares, Naya Bellaubi, González, Lidia Martín, Fernández, Magda Muelas, Padilla, Eduardo, Zorrilla, Silvia Gomez, Enguidanos, Maria Rosa Laplace, Jofre, Clara Sala, Arango, Mauricio Valencia, Pascua, Pilar Marcos, Chippiraz, Elisabet Lerma, Sureda, Teresa Falgueras, González, Melisa Barrantes, Saballs, Mireia, Taha, Mohamed Sufian Al-dirra, Guitart, Silvia Sancliment, Larrainzar-Coghen, Thais, Toboso, Sebastián Hernández, Rodriguez, Irene Sánchez, Fraile, Maria José, Torras, Sara Garcia, Guitard-Quer, Alba, Castellana-Perelló, Dolors, Sáenz, Alfredo Jover, Ramírez-Hidalgo, María, Pardo, Graciano García, Garriga, Imma Grau, Palau, Damaris Berbel, Moral, Alícia, Vilamala, Anna, Montal, Camil·la Valls, Navarro, Maria, Valls, Mariona Xercavins, Anaya, Gisela Cuadrado, Ochoa, Ivett Suárez, Matellanes, Julen Montoya, Trevisanello, Lucia, Segarra, Glòria Garcia, Prieto, Natacha Recio, Azcona, Ana Felisa Lopez, Iftimie, Simona Mihaella, Jaime, Laura Cabrera, Margall, Nuri Quer, Laporte, Júlia, González, Carlota Gudiol, Sanmartí, Montserrat, Diaz-Brito, Vicens, Belda, Alejandro Sanjuan, Sanz, Marta Milián, Giménez-Pérez, Montserrat, Hernández, Sergi, Padullés, Ariadna, Boix-Palop, Lucía, Grau, Santiago, Badia, Josep M., Ferrer, Ricard, Calbo, Esther, Limón, Enric, Pujol, Miquel, and Horcajada, Juan P.

Published
2024
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4. Reducing the duration of antibiotic therapy in surgical patients through a specific nationwide antimicrobial stewardship program. A prospective, interventional cohort study

Author

Sabé, Núria, Martins, Marlene Álvarez, Smithson, Alejandro, Ros, Núria Bosacoma, Gomila-Grange, Aina, Pomar, Virginia, Toboso, Sebastián Hernández, Murgadella-Sancho, Anna, Perez-Hita, Anna Oller, Temple, Marina del, Molpeceres, Sonia Vega, Pardo, Dolors Rodríguez, Río, Ana del, Luque, Maria Fernanda Solano, Blanco, Naiara Villalba, Acedo, Susana Otero, Guitart, Silvia Sancliment, Nicolas, Elisabeth Mauri, Noblia-Gigena, Laura Beatriz, Pérez, Oscar del Río, Rodriguez, Maria Placeres Garcia, Barcons, Irina Aguilar, Serra, Natàlia Juan, Calva, Luis Cajamarca, Lérida, Ana, Torras, Sara Garcia, Martínez, Lourdes Hernández, Miñambres, Carla, Matellane, Julen Montoya, Jofre, Clara Sala, Estada, Sara Burgués, Carrascosa, Montserrat Carrascosa, Mota, Susana Torrecillas, Barrena, Daniel Serrano, Batlle, Maria, Badia, Josep M., Hernández, Sergi, Grau, Santiago, Padulles, Ariadna, Boix-Palop, Lucía, Giménez-Pérez, Montserrat, Ferrer, Ricard, Calbo, Esther, Limón, Enric, Pujol, Miquel, and Horcajada, Juan P.

Published
2023
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6. Programa de Reducción de la Infección Quirúrgica del Observatorio de Infección en Cirugía (PRIQ-O). Documento de priorización y consenso Delphi de recomendaciones para la prevención de la infección de localización quirúrgica

Author

Badia, Josep M, del Toro, M Dolores, Navarro Gracia, Juan F, Balibrea, José M, Herruzo, Rafael, González Sánchez, Carmen, Lozano García, Javier, Rubio Pérez, Inés, Guirao, Xavier, Soria-Aledo, Víctor, and Ortí-Lucas, Rafael

Published
2023
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8. List of Contributors

Author

Ahmed, Ahsan, primary, Aisa, Tharwat, additional, Aleman, Maria Jimena, additional, Alvarado, Gabriela, additional, Gil Anton, Javier, additional, Aranda, Zulmi, additional, Arina, Pietro, additional, Atagi, Kazuaki, additional, Badia, Josep M., additional, Baldisseri, Marie, additional, Barrasa, Helena, additional, de Carlos, Juan Carlos, additional, Centeno, Clara, additional, Mishra, Rajesh Chandra, additional, Chiscano-Camón, Luis, additional, Coopersmith, Craig, additional, Crespo, Rafael Zaragoza, additional, Cruz, Luisa, additional, Escorza, Jeanette Zúñiga, additional, Esteban, Elisabeth, additional, Ferrer, Ricard, additional, Fonseca-Ferrer, Vanessa, additional, Fonseca, Fernando, additional, Gerena-Montano, Luis, additional, Gorordo-Delsol, Luis Antonio, additional, Gotur, Deepa, additional, Guirao, Xavier, additional, Hedjal, Jamila, additional, Hegazy, Ahmed F., additional, Hidalgo, Allyson, additional, Hidalgo, Jorge, additional, Jacobi, Judith, additional, Johnson, Laura S., additional, Juvany, Montserrat, additional, Ko, Ryoung-Eun, additional, Lai, Christopher, additional, Lopa, Ahsina Jahan, additional, Lyons, John, additional, Mahdy, Saad, additional, Malbrain, Manu L.N.G., additional, Martin, Alex, additional, Maynar, Javier, additional, Mazzei, Michael, additional, Mekeirele, Michaël, additional, Merinos-Sánchez, Graciela, additional, Morales-Colón, Sulimar, additional, Morazan, Gerhaldine, additional, Nanayakkara, Prabath W.B., additional, Sanchez Nava, Victor Manuel, additional, Ramirez Garcia, Hector Alejandro, additional, Nieves-Torres, Lucila, additional, Olivero, Lorenzo J., additional, Orellana Jimenez, Carlos Enrique A., additional, Paiva, José-Artur, additional, Paranjape, Ketan, additional, Perez-Fernandez, Javier, additional, Pérez-Nieto, Orlando, additional, Perez, Paola, additional, Plata Menchaca, Erika-Paola, additional, Reed, Mary Jane, additional, Rello, Jordi, additional, Rodríguez-Cintrón, William, additional, Rodríguez-Vega, Gloria M., additional, Rubio Mateo-Sidron, Jose Alfonso, additional, Ruiz-Rodríguez, Juan Carlos, additional, Sánchez, Carlos, additional, Sánchez, Juan Ignacio, additional, Sa, Marcio Borges, additional, Schinkel, Michiel, additional, Shah, Reena, additional, Sinclair De Frías, Jorge E., additional, Sinclair Avila, Jorge E., additional, Singer, Mervyn, additional, Sinha, Sharmili, additional, Suh, Gee Young, additional, Taha, Ahmed Reda, additional, Teboul, Jean-Louis, additional, Torres, Arlene C., additional, Usón, Elena, additional, Vanhonacker, Domien, additional, Wiersinga, W. Joost, additional, Zamarrón, Eder, additional, and Zimmerman, Janice L., additional

Published
2023
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9. What have we learned from the surveys of the AEC, AECP and the Observatory of Infection in Surgery? Compliance with postoperative infection prevention measures and comparison with the AEC recommendations

Author

Al-Raies Bolaño, Bader, Bravo-Brañas, Elena, Calderón Nájera, Ramón, Chamorro Pons, Manuel, Diez, Cecilia, Meijome, Xosé M., López Menéndez, José, Ocaña Guaita, Julia, Ortega Pérez, Gloria, Paredes Esteban, Rosa, Picardo, Antonio L., Sánchez Viguera, Cristina, Vilallonga, Ramón, Badia, Josep M., Amillo Zaragüeta, Mireia, Rubio-Pérez, Inés, Espin-Basany, Eloy, González Sánchez, Carmen, and Balibrea, José M.

Published
2022
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12. Appropriate Use of Antibiotics in Acute Pancreatitis: A Scoping Review.

Author

Badia, Josep M., Amador, Sara, González-Sánchez, Carmen, Rubio-Pérez, Inés, Manuel-Vázquez, Alba, Juvany, Montserrat, Membrilla, Estela, Balibrea, José M., and Guirao, Xavier

Subjects
DRUG resistance in bacteria, COMPUTED tomography, ANTIFUNGAL agents, RANDOMIZED controlled trials, MYCOSES
Abstract

Background: While selective use of antibiotics for infected pancreatic necrosis (IPN) in acute pancreatitis (AP) is recommended, studies indicate a high rate of inadequate treatment. Methods: A search of PubMed, Scopus, and Cochrane databases was conducted, focusing on primary research and meta-analyses. Data were categorized based on core concepts, and a narrative synthesis was performed. Results: The search identified a total of 1016 publications. After evaluating 203 full texts and additional sources from the grey literature, 80 studies were included in the review. The answers obtained were: (1) Preventive treatment does not decrease the incidence of IPN or mortality. Given the risks of bacterial resistance and fungal infections, antibiotics should be reserved for highly suspected or confirmed IPN; (2) The diagnosis of IPN does not always require microbiological samples, as clinical suspicion or computed tomography signs can suffice. Early diagnosis and treatment may be improved by using biomarkers such as procalcitonin and novel microbiological methods; (3) When indicated, early initiation of antibiotics is a key determinant in reducing mortality associated with IPN; (4) Antibiotics with good penetration into pancreatic tissue covering Gram-negative and Gram-positive bacteria should be used. Routine antifungal therapy is not recommended; (5) The step-up approach, including antibiotics, is the standard for IPN management; (6) Antibiotic duration should be kept to a minimum and should be based on the quality of source control and patient condition. Conclusions: Early antibiotic therapy is essential for the treatment of IPN, but prophylactic antibiotics are not recommended in AP. High-quality randomized controlled trials are required to better understand the role of antibiotics and antifungals in AP management. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Recommendations on intervention for hepatobiliary oncological surgery during the COVID-19 pandemic

Author

Balibrea, Jose M., Rubio-Pérez, Inés, Badia, Josep M., Martin-Antona, Esteban, Peña, Estibaliz Álvarez, Garcia-Botella, Alejandra, Martín-Pérez, Elena, Gallego, Mario Álvarez, Cortijo, Sagrario Martínez, Migueláñez, Isabel Pascual, Díaz, Lola Pérez, Ramos Rodríquez, José Luis, Espín-Basany, Eloy, Santos, Raquel Sánchez, Garriga, Xavier Guirao, Aranda Narváez, José Manuel, Morales-Conde, Salvador, García Botella, Alejandra, Gómez Bravo, Miguel Angel, Di Martino, Marcello, Gastaca, Mikel, Sánchez Cabús, Santiago, Sánchez Pérez, Belinda, López Ben, Santiago, Rodríguez Sanjuán, Juan Carlos, López-Andújar, Rafael, and Barrera, Manuel

Published
2021
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16. Recomendaciones de actuación en cirugía oncológica hepatobiliopancreática durante la pandemia COVID-19

Author

García Botella, Alejandra, Gómez Bravo, Miguel Angel, Di Martino, Marcello, Gastaca, Mikel, Martín-Pérez, Elena, Sánchez Cabús, Santiago, Sánchez Pérez, Belinda, López Ben, Santiago, Rodríguez Sanjuán, Juan Carlos, López-Andújar, Rafael, Barrera, Manuel, Balibrea, Jose M., Rubio-Pérez, Inés, Badia, Josep M., Martin-Antona, Esteban, Álvarez Peña, Estibaliz, Garcia-Botella, A., Álvarez Gallego, Mario, Martínez Cortijo, Sagrario, Pascual Migueláñez, Isabel, Pérez Díaz, Lola, Ramos Rodríquez, José Luis, Espín-Basany, Eloy, Sánchez Santos, Raquel, Guirao Garriga, Xavier, Aranda Narváez, José Manuel, and Morales-Conde, Salvador

Published
2021
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17. Executive summary of the Consensus Document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and of the Spanish Association of Surgeons (AEC) in antibiotic prophylaxis in surgery

Author

del Toro López, Mª Dolores, Arias Díaz, Javier, Balibrea, José M., Benito, Natividad, Canut Blasco, Andrés, Esteve, Erika, Horcajada, Juan Pablo, Ruiz Mesa, Juan Diego, Vázquez, Alba Manuel, Muñoz Casares, Cristóbal, del Pozo, Jose Luis, Pujol, Miquel, Riera, Melchor, Jimeno, Jaime, Rubio Pérez, Inés, Ruiz-Tovar Polo, Jaime, Serrablo, Alejandro, Soriano, Alex, and Badia, Josep M.

Published
2021
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18. Executive summary of the Consensus Document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and of the Spanish Association of Surgeons (AEC) in antibiotic prophylaxis in surgery

Author

del Toro López, M. Dolores, Arias Díaz, Javier, Balibrea, José M., Benito, Natividad, Canut Blasco, Andrés, Esteve, Erika, Horcajada, Juan Pablo, Ruiz Mesa, Juan Diego, Vázquez, Alba Manuel, Muñoz Casares, Cristóbal, del Pozo, Jose Luis, Pujol, Miquel, Riera, Melchor, Jimeno, Jaime, Rubio Pérez, Inés, Ruiz-Tovar Polo, Jaime, Serrablo, Alejandro, Soriano, Alex, and Badia, Josep M.

Published
2021
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19. Resumen ejecutivo del Documento de Consenso de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) y de la Asociación Española de Cirujanos (AEC) en profilaxis antibiótica en cirugía

Author

del Toro López, M. Dolores, Arias Díaz, Javier, Balibrea, José M., Benito, Natividad, Canut Blasco, Andrés, Esteve, Erika, Horcajada, Juan Pablo, Ruiz Mesa, Juan Diego, Manuel Vázquez, Alba, Muñoz Casares, Cristóbal, del Pozo, Jose Luis, Pujol, Miquel, Riera, Melchor, Jimeno, Jaime, Rubio Pérez, Inés, Ruiz-Tovar Polo, Jaime, Serrablo, Alejandro, Soriano, Alex, and Badia, Josep M.

Published
2021
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20. Comparison of two bundles for reducing surgical site infection in colorectal surgery: multicentre cohort study.

Author

Flores-Yelamos, Miriam, Gomila-Grange, Aina, Badia, Josep M, Almendral, Alexander, Vázquez, Ana, Parés, David, Pascual, Marta, Limón, Enric, Pujol, Miquel, Juvany, Montserrat, and Team, members of the VINCat Colorectal Surveillance

Subjects
SURGICAL site infections, RECTAL surgery, ELECTIVE surgery, PROCTOLOGY, INFECTION prevention, ANTIBIOTIC prophylaxis
Abstract

Background There is controversy regarding the maximum number of elements that can be included in a surgical site infection prevention bundle. In addition, it is unclear whether a bundle of this type can be implemented at a multicentre level. Methods A pragmatic, multicentre cohort study was designed to analyse surgical site infection rates in elective colorectal surgery after the sequential implementation of two preventive bundle protocols. Secondary outcomes were to determine compliance with individual measures and to establish their effectiveness, duration of stay, microbiology and 30-day mortality rate. Results A total of 32 205 patients were included. A 50% reduction in surgical site infection was achieved after the implementation of two sequential sets of bundles: from 18.16% in the Baseline group to 10.03% with Bundle-1 and 8.19% with Bundle-2. Bundle-2 reduced superficial-surgical site infection (OR 0.74 (95% c.i. 0.58 to 0.95); P = 0.018) and deep-surgical site infection (OR 0.66 (95% c.i. 0.46 to 0.93); P = 0.018) but not organ/space-surgical site infection (OR 0.88 (95% c.i. 0.74 to 1.06); P = 0.172). Compliance increased after the addition of four measures to Bundle-2. In the multivariable analysis, for organ/space-surgical site infection, laparoscopy, oral antibiotic prophylaxis and mechanical bowel preparation were protective factors in colonic procedures, while no protective factors were found in rectal surgery. Duration of stay fell significantly over time, from 7 in the Baseline group to 6 and 5 days for Bundle-1 and Bundle-2 respectively (P < 0.001). The mortality rate fell from 1.4% in the Baseline group to 0.59% and 0.6% for Bundle-1 and Bundle-2 respectively (P < 0.001). There was an increase in Gram-positive bacteria and yeast isolation, and reduction in Gram-negative bacteria and anaerobes in organ/space-surgical site infection. Conclusions The addition of measures to create a final 10-measure protocol had a cumulative protective effect on reducing surgical site infection. However, organ/space-surgical site infection did not benefit from the addition. No protective measures were found for organ/space-surgical site infection in rectal surgery. Compliance with preventive measures increased from Bundle-1 to Bundle-2. [ABSTRACT FROM AUTHOR]

Published
2024
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21. The persistent breach between evidence and practice in the prevention of surgical site infection. Qualitative study

Author

Badia, Josep M., Rubio-Pérez, Inés, López-Menéndez, José, Diez, Cecilia, Al-Raies Bolaños, Bader, Ocaña-Guaita, Julia, Meijome, Xose M., Chamorro-Pons, Manuel, Calderón-Nájera, Ramón, Ortega-Pérez, Gloria, Paredes-Esteban, Rosa, Sánchez-Viguera, Cristina, Vilallonga, Ramon, Picardo, Antonio L., Bravo-Brañas, Elena, Espin, Eloy, and Balibrea, José M.

Published
2020
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23. COVID-19: conceptos clave para el cirujano

Author

Martín Antona, Esteban, Álvarez Peña, Estíbaliz, García Botella, Sandra, Martín Pérez, Elena, Álvarez Gallego, Mario, Martínez Cortijo, Sagrario, Pascual Migueláñez, Isabel, Pérez Díaz, Lola, Ramos Rodríquez, José Luis, Espín Basany, Eloy, Sánchez Santos, Raquel, Morales Conde, Salvador, Rubio-Pérez, Inés, Badia, Josep M., Mora-Rillo, Marta, Martín Quirós, Alejandro, García Rodríguez, Julio, and Balibrea, Jose M.

Published
2020
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24. Surgical Management of Patients With COVID-19 Infection. Recommendations of the Spanish Association of Surgeons

Author

Balibrea, Jose M., Badia, Josep M., Rubio Pérez, Inés, Martín Antona, Esteban, Álvarez Peña, Estíbaliz, García Botella, Sandra, Álvarez Gallego, Mario, Martín Pérez, Elena, Martínez Cortijo, Sagrario, Pascual Miguelañez, Isabel, Pérez Díaz, Lola, Ramos Rodriguez, Jose Luis, Espin Basany, Eloy, Sánchez Santos, Raquel, Soria Aledo, Victoriano, López Barrachina, Ruth, and Morales-Conde, Salvador

Published
2020
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28. Reducing the duration of antibiotic therapy in surgical patients through a specific nationwide antimicrobial stewardship program. A prospective, interventional cohort study

Author

Batlle, Maria, primary, Badia, Josep M., additional, Hernández, Sergi, additional, Grau, Santiago, additional, Padulles, Ariadna, additional, Boix-Palop, Lucía, additional, Giménez-Pérez, Montserrat, additional, Ferrer, Ricard, additional, Calbo, Esther, additional, Limón, Enric, additional, Pujol, Miquel, additional, Horcajada, Juan P., additional, Sabé, Núria, additional, Martins, Marlene Álvarez, additional, Smithson, Alejandro, additional, Ros, Núria Bosacoma, additional, Gomila-Grange, Aina, additional, Pomar, Virginia, additional, Toboso, Sebastián Hernández, additional, Murgadella-Sancho, Anna, additional, Perez-Hita, Anna Oller, additional, Temple, Marina del, additional, Molpeceres, Sonia Vega, additional, Pardo, Dolors Rodríguez, additional, Río, Ana del, additional, Luque, Maria Fernanda Solano, additional, Blanco, Naiara Villalba, additional, Acedo, Susana Otero, additional, Guitart, Silvia Sancliment, additional, Nicolas, Elisabeth Mauri, additional, Noblia-Gigena, Laura Beatriz, additional, Pérez, Oscar del Río, additional, Rodriguez, Maria Placeres Garcia, additional, Barcons, Irina Aguilar, additional, Serra, Natàlia Juan, additional, Calva, Luis Cajamarca, additional, Lérida, Ana, additional, Torras, Sara Garcia, additional, Martínez, Lourdes Hernández, additional, Miñambres, Carla, additional, Matellane, Julen Montoya, additional, Jofre, Clara Sala, additional, Estada, Sara Burgués, additional, Carrascosa, Montserrat Carrascosa, additional, Mota, Susana Torrecillas, additional, and Barrena, Daniel Serrano, additional

Published
2023
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34. Evidencia científica de la duración del tratamiento antibiótico en las infecciones intraabdominales con control de foco quirúrgico

Author

Membrilla Fernández, Estela, Gómez Zorrilla, Silvia, González-Castillo, Ana María, Pelegrina-Manzano, Amalia, Guzmán-Ahumada, Juan, Prim, Núria, Daniel, Echeverría-Esnal, Grau-Cerrato, Santiago, Horcajada, Juan Pablo, Badia, Josep M, and Sancho Insenser, Juan Jose

Subjects
Durada del tractament antimicrobià, Sepsi intraabdominal, Tractament antibiòtic, Teràpia antibiòtica, Duration of antimicrobial treatment, Brief antibiotic prophylaxis and abdominal surgery, Intra-abdominal sepsis, Intra-abdominal infection, Infección intraabdominal, Programes d'optimització ús d'antibiòtics, Prophylactic antibiotics, Antibiòtics profilàctics, Sepsis intra abdominal, Infecció intraabdominal, Tratamiento antibiótico, Profilaxis antibiótica breve y cirugía abdominal, Antibiotic use optimization programs, Antibiotic therapy, Antibiotic treatment, Profilaxi antibiòtica breu i cirurgia abdominal, Duración del tratamiento antimicrobiano, Terapia antibiótica, Surgery, Antibióticos profilácticos, Programas de optimización uso de antibióticos
Abstract

El aumento progresivo de las resistencias antibióticas apremia el tener estrategias para disminuir la presión sobre la microbiota. La duración del tratamiento antibiótico empírico es variable, a pesar de las recomendaciones de las guías. Se ha realizado una revisión bibliográfica de la evidencia científica publicada sobre la duración del tratamiento antibiótico empírico en las infecciones intraabdominales quirúrgicas con control de foco efectivo. Se analizan las guías americanas realizadas por Mazuski et al. de 2017 como eje central en las recomendaciones de la duración de tratamiento antibiótico empírico en infecciones intraabdominales con control del foco y se añade una búsqueda bibliográfica de todos los artículos que contuviesen las palabras claves en Pubmed y Google Scholar. Se recopilan 21 artículos referentes en la duración del tratamiento antibiótico empírico en la infección intraabdominal con control del foco. Con las guías americanas y estos artículos se ha elaborado una propuesta de duración del tratamiento antibiótico empírico en pacientes sin factores de riesgo entre 24 y 72 h. Y en los que presentan factores de riesgo se habría de individualizar el mismo con monitorización activa cada 24 h de fiebre, íleo paralítico y leucocitosis, ante una detección precoz de complicaciones o de necesidad de cambios en el espectro antibiótico. Los tratamientos cortos son igual de eficaces que los de duraciones más prolongadas y se asocian a menos tasa de efectos adversos, por tanto, ajustar y revaluar diariamente la duración del tratamiento antibiótico empírico es fundamental para una mejor praxis. A non-systematic review of the published scientific evidence has been carried out on the duration of empirical antibiotic treatment in surgical intra-abdominal infections with effective focus control. Given the progressive increase in antibiotic resistance, it is urgent to have strategies to reduce the pressure on the microbiota. The American guidelines made by Mazuski et al. of 2017, as the central axis in the recommendations of the duration of empirical antibiotic treatment in intra-abdominal infections with control of the focus and a bibliographic search of all the articles that contained the keywords in Pubmed and Google Scholar is added. 21 articles referring to the duration of empirical antibiotic treatment in intra-abdominal infection with control of the focus are collected. With the American guidelines and these articles, a proposal is prepared for the duration of empirical antibiotic treatment in patients without risk factors between 24 and 72 h. And in those who present risk factors, it should be individualized with active monitoring every 24 h of fever, paralytic ileus and leukocytosis, before an early detection of complications or the need for changes in antibiotic treatment. Short treatments are just as effective as those of longer durations and are associated with fewer adverse effects, therefore, daily adjusting and reassessing the duration of empirical antibiotic treatment is essential for better practice. info:eu-repo/semantics/publishedVersion

Published
2022

37. Programa de Reducción de la Infección Quirúrgica del Observatorio de Infección en Cirugía (PRIQ-O). Documento de priorización y consenso Delphi de recomendaciones para la prevención de la infección de localización quirúrgica

Author

Universidad de Sevilla. Departamento de Medicina, Badia, Josep M., Toro López, María Dolores del, Navarro Gracia, Juan F., Balibrea, José M., Herruzo, Rafael, González Sánchez, Carmen, Lozano García, Javier, Rubio Pérez, Inés, Guirao, Xavier, Soria Aledo, Víctor, Ortí Lucas, Rafael, Universidad de Sevilla. Departamento de Medicina, Badia, Josep M., Toro López, María Dolores del, Navarro Gracia, Juan F., Balibrea, José M., Herruzo, Rafael, González Sánchez, Carmen, Lozano García, Javier, Rubio Pérez, Inés, Guirao, Xavier, Soria Aledo, Víctor, and Ortí Lucas, Rafael

Abstract

La infección de localización quirúrgica es la complicación más frecuente y más evitable de la cirugía, pero las guías clínicas para su prevención tienen un seguimiento insuficiente. Presentamos los resultados de un consenso Delphi realizado por un panel de expertos de 17 sociedades científicas con revisión crítica de la evidencia científica y guías internacionales, para seleccionar las medidas con mayor grado de evidencia y facilitar su implementación. Se revisaron 40 medidas y se emitieron 53 recomendaciones. Se priorizan 10 medidas principales para su inclusión en bundles de prevención: ducha preoperatoria; correcta higiene quirúrgica de manos; no eliminación del vello del campo quirúrgico o eliminación con maquinilla eléctrica; profilaxis antibiótica sistémica adecuada; uso de abordajes mínimamente invasivos; descontaminación de la piel con soluciones alcohólicas; mantenimiento de la normotermia; protectores-retractores plásticos de herida; cambio de guantes intraoperatorio, y cambio de material quirúrgico y auxiliar antes del cierre de las heridas., Surgical site infection is the most frequent and avoidable complication of surgery, but clinical guidelines for its prevention are insufficiently followed. We present the results of a Delphi consensus carried out by a panel of experts from 17 Scientific Societies with a critical review of the scientific evidence and international guidelines, to select the measures with the highest degree of evidence and facilitate their implementation. Forty measures were reviewed and 53 recommendations were issued. Ten main measures were prioritized for inclusion in prevention bundles: preoperative shower; correct surgical hand hygiene; no hair removal from the surgical field or removal with electric razors; adequate systemic antibiotic prophylaxis; use of minimally invasive approaches; skin decontamination with alcoholic solutions; maintenance of normothermia; plastic wound protectors-retractors; intraoperative glove change; and change of surgical and auxiliary material before wound closure.

Published
2023

42. An Open Software Development-based Ecosystem of R Packages for Metabolomics Data Analysis

Author

Vicini, Andrea, Gine, Roger, Stravs, Michele, Badia, Josep M, Huber, Carolin, Salzer, Liesa, Stanstrup, Jan, Shahaf, Nir, Naake, Thomas, Hecht, Helge, Neumann, Steffen, Witting, Michael, Gibb, Sebastian, Gatto, Laurent, and Rainer, Johannes

Subjects
Open Software Development, Annotation, Metabolomics, Mass Spectrometry
Abstract

Lack of support, maintenance and further development is common with scientific research software. In particular, development by a single researcher can easily result in orphaned software packages, especially if combined with poor documentation or lack of adherence to open software development standards. The RforMassSpectrometry initiative aims to develop an efficient, thoroughly documented and stable infrastructure for mass spectrometry (MS) data analysis. As part of this initiative, a growing ecosystem of R software packages was and is being developed covering different aspects of metabolomics and proteomics data analysis. To avoid the aforementioned problems open shared development, documentation, support and stability are emphasized. At the heart of the package ecosystem is the Spectra package, that provides the core infrastructure to handle MS data. Core functionality, which can be easily re-used by other R software packages, is provided by the MsCoreUtils and MetaboCoreUtils packages. Version 4 of the xcms package for LC-MS data pre-processing is now based mainly on this new infrastructure hence gaining support for additional data types, better data handling and support for ion mobility data. Integration of the xcms package into the package ecosystem simplifies complete analysis workflows which can include the MsFeatures package for feature grouping, and the MetaboAnnotation package for annotation of untargeted metabolomics data. Seamless integration of publicly available annotation resources is possible through packages such as MsBackendMassbank, MsBackendMsp or CompoundDb, the latter also allowing to create and manage lab-specific annotation resources. MsQuality enables rapid, efficient, and standardized quality assessment of MS data. Finally, integration of Python based functionality, such as provided by the matchms package, is possible through the SpectriPy package, and the SpectraQL adds support for the MassQL common query language to R/Spectra., contact: johannes.rainer@eurac.edu, {"references":["Naake, Thomas et al (2023). MsQuality – an interoperable open-source package for the calculation of standardized quality metrics of mass spectrometry data. bioRxiv https://doi.org/10.1101/2023.05.12.540477","Rainer, Johannes et al. (2022). A Modular and Expandable Ecosystem for Metabolomics Data Annotation in R. Metabolites. https://doi.org/10.3390/metabo12020173","Kockmann, Thomas et al. (2021). The rawrr R Package: Direct Access to Orbitrap Data and Beyond. Journal of Proteome Research. https://doi.org/10.1021/acs.jproteome.0c00866","Huber, Florian et al. (2020). matchms – processing and similarity evaluation of mass spectrometry data. JOSS https://doi.org/10.21105/joss.02411","Jarmusch, Alan K et al. (2022). A Universal Language for Finding Mass Spectrometry Data Patterns. bioRxiv https://doi.org/10.1101/2022.08.06.503000"]}

Published
2023
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43. Vigilància de les Infeccions relacionades amb l’atenció sanitària de Catalunya (VINCat) - 2022

Author

Badia, Josep M, Barrufet, Pilar, Calbo, Esther, Besoli, Anna, Casas, Irma, Diaz, Emili, Domènech-Bagué, Dolors, García, Pilar M, Gasch, Oriol, Giménez Hernández, Montserrat, Horcajada, Juan Pablo, Hornero, Ana, Jover-Saenz, Alfredo, López, Ana Felisa, Lopez-Contreras, Joaquin, Martinez Martinez, Jose Antonio, Melendo, Susana, Nuvials, Xavier, Padullés-Zamora, Ariadna, Pomar, Virginia, Smithson, Alex, Sopena, Nieves, Urrea Ayala, Mireia, Hernández Baeza, Sergi, Porrón, Rosario, Almendral, Alexander, Larrosa, María Nieves, Moreno, Esther, and Departament de Salut

Subjects
Catalonia, infecciones bacterianas y micosis::infección::infección hospitalaria [ENFERMEDADES], Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires::Health Surveys::Health Status Indicators [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Infeccions nosocomials - Epidemiologia - Catalunya, Other subheadings::Other subheadings::/epidemiology [Other subheadings], Cataluña, Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores], técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios::encuestas de salud::indicadores de salud [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Indicadors de salut - Catalunya, RA644.N66 P762, Bacterial Infections and Mycoses::Infection::Cross Infection [DISEASES]
Abstract

Infeccions nosocomials; Hospitals; Vigilància epidemiològica Infecciones nosocomiales; Hospitales; Vigilancia epidemiológica Nosocomial infections; Hospitals; Epidemiological surveillance VINCat és un programa que estableix un sistema de vigilància unificat de les infeccions nosocomials als hospitals de Catalunya. La seva missió és contribuir a reduir les taxes d'aquestes infeccions mitjançant la vigilància epidemiològica activa i continuada. El programa es fonamenta en la tasca que porten a terme els professionals dels equips multidisciplinaris de control d'infecció dels hospitals catalans. VINCat is a program of the Catalan Health Service that establishes a unified surveillance system for nosocomial infections in hospitals in Catalonia. Its mission is to help reduce the rates of these infections through active and ongoing epidemiological surveillance. The program is based on the work carried out by the multidisciplinary teams of infection control of Catalan hospitals. VINCat es un programa del Servicio Catalán de la Salud que establece un sistema de vigilancia unificado de las infecciones nosocomiales en los hospitales de Cataluña. Su misión es contribuir a reducir las tasas de estas infecciones mediante la vigilancia epidemiológica activa y continuada. El programa se fundamenta en la tarea que llevan a cabo los profesionales de los equipos multidisciplinares de control de infección de los hospitales catalanes.

Published
2023

46. Surgical Infection Reduction Program of the Observatory of Surgical Infection (PRIQ-O). Delphi prioritization and consensus document on recommendations for the prevention of surgical site infection

Author

Badia, Josep M., primary, Dolores del Toro, M., additional, Navarro Gracia, Juan F., additional, Balibrea, José M., additional, Herruzo, Rafael, additional, González Sánchez, Carmen, additional, Lozano García, Javier, additional, Rubio Pérez, Inés, additional, Guirao, Xavier, additional, Soria-Aledo, Víctor, additional, and Ortí-Lucas, Rafael, additional

Published
2022
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50. An interventional nationwide surveillance program lowers postoperative infection rates in elective colorectal surgery. A cohort study (2008-2019)

Author

Arroyo-García, Nares, Badia, Josep M., Vázquez, Ana, Pera Roman, Miguel, Parés, David, Limón, Enric, Almendral, Alexander, Piriz, Marta, Cecilia, Díez, Fraccalvieri, Domenico, López Contreras, Joaquín, Pujol, Miquel, Colorectal Surveillance Team, VINCat Program, Arroyo-García, Nares, Badia, Josep M., Vázquez, Ana, Pera Roman, Miguel, Parés, David, Limón, Enric, Almendral, Alexander, Piriz, Marta, Cecilia, Díez, Fraccalvieri, Domenico, López Contreras, Joaquín Pujol, Miquel, Colorectal Surveillance Team, VINCat Program, [Arroyo-Garcia N, Badia JM] Department of Surgery, Hospital General Granollers, Granollers, Spain. School of Medicine, Universitat Internacional de Catalunya, Barcelona, Spain. [Vázquez A] Servei d’Estadística Aplicada, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Pera M] Department of Surgery, Hospital del Mar, Barcelona, Spain. [Parés D] Department of Surgery, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. [Limón E] VINCat Program, Universitat de Barcelona, Barcelona, Spain, and Hospital General de Granollers

Subjects
Prevenció i control, Infeccions quirúrgiques, Cirurgia colorectal, Surgical wound infection, Estudios de cohortes, Infection control, Còlon - Cirurgia, Cohort Studies, Health Occupations::Medicine::Specialties, Surgical::Colorectal Surgery [DISCIPLINES AND OCCUPATIONS], Cirugía colorrectal, Control d'infeccions, Prevención y control, Colorectal surgery, Risk Factors, Infección del sitio quirúrgico, Humans, Surgical Wound Infection, Estudis de cohorts, Epidemiologia, Proporción de infección estandarizada, Digestive System Surgical Procedures, Standardized infection ratio, Infecció del lloc quirúrgic, Adverse effects, Prevention & control, Infeccions quirúrgiques - Estudi de casos, Cirurgia colorrectal, General Medicine, Efectos adversos, Infección de la herida quirúrgica, Elective Surgical Procedures, profesiones sanitarias::medicina::especialidades quirúrgicas::cirugía colorrectal [DISCIPLINAS Y OCUPACIONES], Ratio d'infecció estandarditzat, Surgery, Efectes adversos, Colorectal Surgery, Surgical site infection, Infecció de ferides quirúrgiques
Abstract

Colorectal surgery; Postoperative infection; Cohort studies Cirugía colorrectal; Infección postoperatoria; Estudios de cohortes Cirurgia colorectal; Infecció postoperatòria; Estudis de cohorts Background: Colorectal surgery is associated with the highest rate of surgical site infection (SSI). This study analyses the effectiveness of an interventional surveillance program on SSI rates after elective colorectal surgery. Material and methods: Cohort study showing temporal trends of SSI rates and Standardized Infection Ratio (SIR) in elective colorectal surgery over a 12-year period. Prospectively collected data of a national SSI surveillance program was analysed and the effect of specific interventions was evaluated. Patient and procedure characteristics, as well as SIR and SSI rates were stratified by risk categories and type of SSI analysed using stepwise multivariate logistic regression models. Results: In a cohort of 42,330 operations, overall cumulative SSI incidence was 16.31%, and organ-space SSI (O/S-SSI) was 8.59%. There was a 61.63% relative decrease in SSI rates (rho = -0.95804). The intervention which achieved the greatest SSI reduction was a bundle of 6 measures. SSI in pre-bundle period was 19.73% vs. 11.10% in post-bundle period (OR 1.969; IC 95% 1.860-2.085; p < 0.0001). O/S-SSI were 9.08% vs. 6.06%, respectively (OR 1.547; IC 95% 1.433-1.670; p < 0.0001). Median length of stay was 7 days, with a significant decrease over the studied period (rho = -0.98414). Mortality of the series was 1.08%, ranging from 0.35% to 2.0%, but a highly significant decrease was observed (rho = -0.67133). Conclusions: Detailed analysis of risk factors and postoperative infection in colorectal surgery allows strategies for reducing SSI incidence to be designed. An interventional surveillance program has been effective in decreasing SIR and SSI rates.

Published
2021

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