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22 results on '"Badusche, Marlis"'

2. The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses

Author

Leggewie, Mayke, primary, Scherer, Christina, additional, Altinli, Mine, additional, Gestuveo, Rommel J., additional, Sreenu, Vattipally B., additional, Fuss, Janina, additional, Vazeille, Marie, additional, Mousson, Laurence, additional, Badusche, Marlis, additional, Kohl, Alain, additional, Failloux, Anna-Bella, additional, and Schnettler, Esther, additional

Published
2023
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4. Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015

Author

Kerber, Romy, Krumkamp, Ralf, Diallo, Boubacar, Jaeger, Anna, Rudolf, Martin, Lanini, Simone, Bore, Joseph Akoi, Koundouno, Fara Raymond, Becker-Ziaja, Beate, Fleischmann, Erna, Stoecker, Kilian, Meschi, Silvia, Mély, Stéphane, Newman, Edmund N. C., Carletti, Fabrizio, Portmann, Jasmine, Korva, Misa, Wolff, Svenja, Molkenthin, Peter, Kis, Zoltan, Kelterbaum, Anne, Bocquin, Anne, Strecker, Thomas, Fizet, Alexandra, Castilletti, Concetta, Schudt, Gordian, Ottowell, Lisa, Kurth, Andreas, Atkinson, Barry, Badusche, Marlis, Cannas, Angela, Pallasch, Elisa, Bosworth, Andrew, Yue, Constanze, Pályi, Bernadett, Ellerbrok, Heinz, Kohl, Claudia, Oestereich, Lisa, Logue, Christopher H., Lüdtke, Anja, Richter, Martin, Ngabo, Didier, Borremans, Benny, Becker, Dirk, Gryseels, Sophie, Abdellati, Saïd, Vermoesen, Tine, Kuisma, Eeva, Kraus, Annette, Liedigk, Britta, Maes, Piet, Thom, Ruth, Duraffour, Sophie, Diederich, Sandra, Hinzmann, Julia, Afrough, Babak, Repits, Johanna, Mertens, Marc, Vitoriano, Inês, Bah, Amadou, Sachse, Andreas, Boettcher, Jan Peter, Wurr, Stephanie, Bockholt, Sabrina, Nitsche, Andreas, Županc, Tatjana Avšič, Strasser, Marc, Ippolito, Giuseppe, Becker, Stephan, Raoul, Herve, Carroll, Miles W., De Clerck, Hilde, Van Herp, Michel, Sprecher, Armand, Koivogui, Lamine, Magassouba, N'Faly, Keïta, Sakoba, Drury, Patrick, Gurry, Cèline, Formenty, Pierre, May, Jürgen, Gabriel, Martin, Wölfel, Roman, Günther, Stephan, and Di Caro, Antonino

Published
2016

6. Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa

Author

Carroll, Miles W., Matthews, David A., Hiscox, Julian A., Elmore, Michael J., Pollakis, Georgios, Rambaut, Andrew, Hewson, Roger, García-Dorival, Isabel, Bore, Joseph Akoi, Koundouno, Raymond, Abdellati, Saïd, Afrough, Babak, Aiyepada, John, Akhilomen, Patience, Asogun, Danny, Atkinson, Barry, Badusche, Marlis, Bah, Amadou, Bate, Simon, Baumann, Jan, Becker, Dirk, Becker-Ziaja, Beate, Bocquin, Anne, Borremans, Benny, Bosworth, Andrew, Boettcher, Jan Peter, Cannas, Angela, Carletti, Fabrizio, Castilletti, Concetta, Clark, Simon, Colavita, Francesca, Diederich, Sandra, Donatus, Adomeh, Duraffour, Sophie, Ehichioya, Deborah, Ellerbrok, Heinz, Fernandez-Garcia, Maria Dolores, Fizet, Alexandra, Fleischmann, Erna, Gryseels, Sophie, Hermelink, Antje, Hinzmann, Julia, Hopf-Guevara, Ute, Ighodalo, Yemisi, Jameson, Lisa, Kelterbaum, Anne, Kis, Zoltan, Kloth, Stefan, Kohl, Claudia, Korva, Miša, Kraus, Annette, Kuisma, Eeva, Kurth, Andreas, Liedigk, Britta, Logue, Christopher H., Lüdtke, Anja, Maes, Piet, McCowen, James, Mély, Stéphane, Mertens, Marc, Meschi, Silvia, Meyer, Benjamin, Michel, Janine, Molkenthin, Peter, Muñoz-Fontela, César, Muth, Doreen, Newman, Edmund N. C., Ngabo, Didier, Oestereich, Lisa, Okosun, Jennifer, Olokor, Thomas, Omiunu, Racheal, Omomoh, Emmanuel, Pallasch, Elisa, Pályi, Bernadett, Portmann, Jasmine, Pottage, Thomas, Pratt, Catherine, Priesnitz, Simone, Quartu, Serena, Rappe, Julie, Repits, Johanna, Richter, Martin, Rudolf, Martin, Sachse, Andreas, Schmidt, Kristina Maria, Schudt, Gordian, Strecker, Thomas, Thom, Ruth, Thomas, Stephen, Tobin, Ekaete, Tolley, Howard, Trautner, Jochen, Vermoesen, Tine, Vitoriano, Inês, Wagner, Matthias, Wolff, Svenja, Yue, Constanze, Capobianchi, Maria Rosaria, Kretschmer, Birte, Hall, Yper, Kenny, John G., Rickett, Natasha Y., Dudas, Gytis, Coltart, Cordelia E. M., Kerber, Romy, Steer, Damien, Wright, Callum, Senyah, Francis, Keita, Sakoba, Drury, Patrick, Diallo, Boubacar, de Clerck, Hilde, Van Herp, Michel, Sprecher, Armand, Traore, Alexis, Diakite, Mandiou, Konde, Mandy Kader, Koivogui, Lamine, Magassouba, N’Faly, Avšič-Županc, Tatjana, Nitsche, Andreas, Strasser, Marc, Ippolito, Giuseppe, Becker, Stephan, Stoecker, Kilian, Gabriel, Martin, Raoul, Hervé, Di Caro, Antonino, Wölfel, Roman, Formenty, Pierre, and Günther, Stephan

Published
2015
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7. Antiviral RNAi Response against the Insect-Specific Agua Salud Alphavirus

Author

Altinli, Mine, primary, Leggewie, Mayke, additional, Badusche, Marlis, additional, Gyanwali, Rashwita, additional, Scherer, Christina, additional, Schulze, Jonny, additional, Sreenu, Vattipally B., additional, Fegebank, Marvin, additional, Zibrat, Bernhard, additional, Fuss, Janina, additional, Junglen, Sandra, additional, and Schnettler, Esther, additional

Published
2022
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8. Antiviral RNAi response against the insect-specific Agua Salud alphavirus

Author

Altinli, Mine, primary, Leggewie, Mayke, additional, Badusche, Marlis, additional, Gyanwali, Rashwita, additional, Scherer, Christina, additional, Schulze, Jonny, additional, Sreenu, Vattipally B., additional, Fegebank, Marvin, additional, Zibrat, Bernhard, additional, Fuss, Janina, additional, Junglen, Sandra, additional, and Schnettler, Esther, additional

Published
2021
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10. Culex pipiens and Culex torrentium populations from Central Europe are susceptible to West Nile virus infection

Author

Leggewie, Mayke, Badusche, Marlis, Rudolf, Martin, Jansen, Stephanie, Börstler, Jessica, Krumkamp, Ralf, Huber, Katrin, Krüger, Andreas, Schmidt-Chanasit, Jonas, Tannich, Egbert, and Becker, Stefanie C.

Subjects
lcsh:R5-920, viruses, fungi, parasitic diseases, virus diseases, Infection assay, lcsh:Medicine (General), West Nile virus, Research Paper, Culex mosquitoes
Abstract

West Nile virus (WNV), a Flavivirus with an avian primary host, is already widespread in Europe and might also pose an infection risk to Germany, should competent mosquito vectors be present. Therefore, we analysed the ability of WNV to infect German Culex mosquitoes with special emphasis on field collected specimens of Culex torrentium and Culex pipiens biotype pipiens. We collected egg rafts of Culex mosquitoes over two subsequent seasons at two geographically distinct sampling areas in Germany and differentiated the samples by molecular methods. Adult females, reared from the various egg rafts, were challenged with WNV by feeding of artificial blood meals. WNV infection was confirmed by real-time RT-PCR and virus titration. The results showed that field collected C. pipiens biotype pipiens and C. torrentium mosquitoes native to Germany are susceptible to WNV infection at 25°C as well as 18°C incubation temperature. C. torrentium mosquitoes, which have not been established as WNV vector so far, were the most permissive species tested with maximum infection rates of 96% at 25°C. Furthermore, a disseminating infection was found in up to 94% of tested C. pipiens biotype pipiens and 100% of C. torrentium. Considering geographical variation of susceptibility, C. pipiens biotype pipiens mosquitoes from Southern Germany were more susceptible to WNV infection than corresponding populations from Northern Germany. All in all, we observed high infection and dissemination rates even at a low average ambient temperature of 18°C. The high susceptibility of German Culex populations for WNV indicates that an enzootic transmission cycle in Germany could be possible.

Published
2016
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15. First Nationwide Surveillance of Culex pipiens Complex and Culex torrentium Mosquitoes Demonstrated the Presence of Culex pipiens Biotype pipiens/molestus Hybrids in Germany

Author

Rudolf, Martin, primary, Czajka, Christina, additional, Börstler, Jessica, additional, Melaun, Christian, additional, Jöst, Hanna, additional, von Thien, Heidrun, additional, Badusche, Marlis, additional, Becker, Norbert, additional, Schmidt-Chanasit, Jonas, additional, Krüger, Andreas, additional, Tannich, Egbert, additional, and Becker, Stefanie, additional

Published
2013
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18. Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized by Lassa virus-specific human CD4+ T-cell clones

Author

Meulen, Jan ter, primary, Badusche, Marlis, additional, Satoguina, Judith, additional, Strecker, Thomas, additional, Lenz, Oliver, additional, Loeliger, Cornelius, additional, Sakho, Mohamed, additional, Koulemou, Kekoura, additional, Koivogui, Lamine, additional, and Hoerauf, Achim, additional

Published
2004
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20. Characterization of Human CD4 + T-Cell Clones Recognizing Conserved and Variable Epitopes of the Lassa Virus Nucleoprotein

Author

ter Meulen, Jan, primary, Badusche, Marlis, additional, Kuhnt, Kristiane, additional, Doetze, Andrea, additional, Satoguina, Judith, additional, Marti, Thomas, additional, Loeliger, Cornelius, additional, Koulemou, Kekoura, additional, Koivogui, Lamine, additional, Schmitz, Herbert, additional, Fleischer, Bernhard, additional, and Hoerauf, Achim, additional

Published
2000
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21. First Nationwide Surveillance of Culex pipiens Complex and Culex torrentium Mosquitoes Demonstrated the Presence of Culex pipiens Biotype pipiens/molestus Hybrids in Germany.

Author

Rudolf, Martin, Czajka, Christina, Börstler, Jessica, Melaun, Christian, Jöst, Hanna, von Thien, Heidrun, Badusche, Marlis, Becker, Norbert, Schmidt-Chanasit, Jonas, Krüger, Andreas, Tannich, Egbert, and Becker, Stefanie

Subjects
CULEX pipiens, MOSQUITOES, ARTHROPODA, WEST Nile fever transmission, CARBON dioxide
Abstract

Mosquitoes and other arthropods may transmit medically important pathogens, in particular viruses such as West Nile virus. The presence of suitable hosts and competent vectors for those zoonotic viruses is essential for an enzootic transmission, which is a prerequisite for epidemics. To establish reliable risk projections, it is an urgent need for an exact identification of mosquito species, which is especially challenging in the case of sibling species, such as Culex. pipiens pipiens biotypes pipiens and molestus. To facilitate detection of different Culex pipiens forms and their hybrids we established a multiplex real-time PCR. Culex pipiens samples were obtained by egg raft collection and rearing until imago stage or adult sampling using CO2 baited traps and gravid traps. In total, we tested more than 16,500 samples collected all over Germany in the years 2011 and 2012. The predominant species in Germany are Culex pipiens pipiens biotype pipiens and Culex. torrentium, but we also detected Culex pipiens pipiens biotype molestus and hybrids of the two pipiens biotypes at sites where both species occur sympatrically. This report of a potentially important bridge vector for West Nile virus might have major impact in the risk projections for West Nile virus in Germany. [ABSTRACT FROM AUTHOR]

Published
2013
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22. Characterization of Human CD4+T-Cell Clones Recognizing Conserved and Variable Epitopes of the Lassa Virus Nucleoprotein

Author

ter Meulen, Jan, Badusche, Marlis, Kuhnt, Kristiane, Doetze, Andrea, Satoguina, Judith, Marti, Thomas, Loeliger, Cornelius, Koulemou, Kekoura, Koivogui, Lamine, Schmitz, Herbert, Fleischer, Bernhard, and Hoerauf, Achim

Abstract

ABSTRACTT cells must play the major role in controlling acute human Lassa virus infection, because patients recover from acute Lassa fever in the absence of a measurable neutralizing antibody response. T cells alone seem to protect animals from a lethal Lassa virus challenge, because after experimental vaccination no neutralizing antibodies are detectable. In order to study human T-cell reactivity to single Lassa virus proteins, the nucleoprotein (NP) of Lassa virus, strain Josiah, was cloned, expressed in Escherichia coli, and affinity purified. Peripheral blood mononuclear cells (PBMC) obtained from 8 of 13 healthy, Lassa virus antibody-positive individuals living in the Republic of Guinea, western Africa, were found to proliferate in response to the recombinant protein (proliferation index =10). PBMC obtained from one individual with a particularly high proliferative response were used to generate 50 NP-specific T-cell clones (TCC). For six of these the epitopes were mapped with overlapping synthetic peptides derived from the sequence of the NP. These CD4+TCC displayed high specific proliferation and produced mainly gamma interferon upon stimulation with NP. Because variation of up to 15% in the amino acid sequences of the structural proteins of naturally occurring Lassa virus variants has been observed, the reactivity of the TCC with peptides derived from the homologous epitopes of the Nigeria strain of Lassa virus and of the eastern Africa arenavirus Mopeia was tested. With the Nigeria strain of Lassa virus the levels of homology were 100% for two of these epitopes and 85% for three of them, whereas homology with the respective Mopeia epitopes ranged from 92 to 69%. Reactivity of the TCC with peptides derived from the variable epitopes of the Nigeria strain and of Mopeia was reduced or completely abolished. This report shows for the first time that seropositive individuals from areas of endemicity have very strong memory CD4+T-cell responses against the NP of Lassa virus, which are partly strain specific and partly cross-reactive with other Lassa virus strains. Our findings may have important implications for the strategy of designing recombinant vaccines against this mainly T-cell-controlled human arenavirus infection.

Published
2000
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