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2. Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules 2024

Author

Park, Young Joo, primary, Lee, Eun Kyung, additional, Song, Young Shin, additional, Kang, Su Hwan, additional, Koo, Bon Seok, additional, Kim, Sun Wook, additional, Na, Dong Gyu, additional, Baek, Seung-Kuk, additional, Oh, So Won, additional, Lee, Min Kyoung, additional, Lee, Sang-Woo, additional, Lee, Young Ah, additional, Lee, Yong Sang, additional, Lee, Ji Ye, additional, Lim, Dong-Jun, additional, Joo, Leehi, additional, Jung, Yuh-Seog, additional, Jung, Chan Kwon, additional, Cho, Yoon Young, additional, Chung, Yun Jae, additional, Kim, Won Bae, additional, Yi, Ka Hee, additional, Kang, Ho-Cheol, additional, and Park, Do Joon, additional

Published
2024
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18. Guideline for the Surgical Management of Locally Invasive Differentiated Thyroid Cancer From the Korean Society of Head and Neck Surgery

Author

Park, Jun-Ook, primary, Kim, Joo Hyun, additional, Joo, Young Hoon, additional, Kim, Sang-Yeon, additional, Kim, Geun-Jeon, additional, Kim, Hyun Bum, additional, Lee, Dong-Hyun, additional, Hong, Hyun Jun, additional, Park, Young Min, additional, Chung, Eun-Jae, additional, Ji, Yong Bae, additional, Oh, Kyoung Ho, additional, Lee, Hyoung Shin, additional, Lee, Dong Kun, additional, Park, Ki Nam, additional, Ban, Myung Jin, additional, Kim, Bo Hae, additional, Kim, Do Hun, additional, Cho, Jae-Keun, additional, Ahn, Dong Bin, additional, Kim, Min-Su, additional, Seok, Jun Girl, additional, Jang, Jeon Yeob, additional, Choi, Hyo Geun, additional, Kim, Hee Jin, additional, Park, Sung Joon, additional, Jung, Eun Kyung, additional, Kim, Yeon Soo, additional, Hong, Yong Tae, additional, Lee, Young Chan, additional, Won, Ho-Ryun, additional, Shin, Sung-Chan, additional, Baek, Seung-Kuk, additional, and Kwon, Soon Young, additional

Published
2023
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28. Matrix Metalloproteinase-7 Induces E-Cadherin Cleavage in Acid-Exposed Primary Human Pharyngeal Epithelial Cells Via The ROS/ERK/c-Jun Pathway

Author

Im, Nu-Ri, Kim, Byoungjae, Jung, Kwang-Yoon, and Baek, Seung-Kuk

Subjects
Adult, Male, MAP Kinase Signaling System, Matrix metalloproteinase-7 (MMP-7), JNK Mitogen-Activated Protein Kinases, Reactive oxygen species (ROS), Epithelial Cells, Laryngopharyngeal reflux, Middle Aged, Cadherins, Young Adult, Antigens, CD, Mitogen-activated protein kinases (MAPK), Matrix Metalloproteinase 7, Drug Discovery, Molecular Medicine, Humans, Pharynx, Female, Original Article, Hydrochloric Acid, Transcription factor, Reactive Oxygen Species, Genetics (clinical), Cells, Cultured
Abstract

Abstract Laryngopharyngeal reflux disease (LPRD) is caused by pharyngeal mucosal damage due to the reflux of gastric contents, including acid, pepsin, and bile juice. Our previous study has demonstrated that LPRD is associated with the cleavage of E-cadherin, which is facilitated by the acid-activated matrix metalloproteinase-7 (MMP-7); however, the mechanism by which the acid activates MMP-7 remains unclear. The purpose of this study was to investigate the mechanism by which MMP-7 is activated in the pharyngeal epithelial cells that are exposed to acid. The levels of reactive oxygen species (ROS) were measured in the epithelial cells exposed to acid. To investigate the signaling mechanism of ROS in the expression of MMP-7, the mechanism of action of the mitogen-activated protein kinase was examined. The expression of various signaling factors was determined, according to the presence or absence of each inhibitor in the acid-exposed pharyngeal epithelial cells. To identify changes in the cleavage of E-cadherin, the integrity of the mucosal membrane was assessed using a transepithelial permeability test. We found that acid exposure increased the levels of ROS, phosphorylated-extracellular signal-regulated kinase (p-ERK) 1/2, and phosphorylated-c-Jun (p–c-Jun) in pharyngeal epithelial cells. The ROS inhibitor reduced the expression of p-ERK and MMP-7, while the ERK inhibitor reduced the expression of p–c-Jun and MMP-7. Moreover, the c-Jun inhibitor reduced the expression of MMP-7 and blocked the degradation of E-cadherin. In addition, decrease in the levels of immunostained E-cadherin and increase in transepithelial permeability after acid exposure were collectively alleviated by the inhibitors of ROS, ERK, and c-Jun. The degradation of E-cadherin that occurs after human mucosal cells are exposed to acid appears to be caused by an increase in the expression of MMP-7 via the ROS/ERK/c-Jun pathway, which is thought to be an important mechanism associated with the development of LPRD. Key messages • ROS is triggered when reflux occurs. • ROS regulates the transcription factor c-Jun via the ERK pathway. • The increase in MMP-7 that induces LPRD is induced via the ROS/ERK/c-Jun pathway. • This study revealed for the first time the expression mechanism of MMP-7, which is one of the causes of LPRD.

Published
2021

31. Association between oral health and thyroid disorders: A population‐based cross‐sectional study.

Author

Kwon, Minsu, Jeong, Yu‐Jin, Kwak, Jiwon, Jung, Kwang‐Yoon, and Baek, Seung‐Kuk

Subjects
THYROID gland function tests, STATISTICS, STATISTICAL significance, THYROID diseases, ORAL hygiene, ORAL health, CROSS-sectional method, ONE-way analysis of variance, MULTIVARIATE analysis, MULTIPLE regression analysis, PERIODONTITIS, PERIODONTAL disease, CHI-squared test, HEALTH behavior
Abstract

Objectives: In this study, we aimed to determine the relationship between oral health status and thyroid dysfunction. Methods: A population‐based cross‐sectional analysis using data from the Korean National Health and Nutrition Examination Survey (KNHNES) was performed. We investigated the association between oral health‐related parameters and the prevalence of thyroid diseases. In addition, the relationship between oral health status and thyroid function test (TFT) results was analyzed. One‐way analysis of variances or chi‐square test was used for comparisons between oral health‐related parameters and presence of thyroid diseases. Univariable and multivariable logistic regression analyses were conducted to evaluate the associations between participants' characteristics including oral health‐related parameters and the abnormal results of TFTs. Results: A total of 18,034 adults were surveyed. Histories of thyroid diseases were found to be more common in people who brushed their teeth frequently or used oral hygiene products. However, histories of periodontitis and community periodontal index (CPI) did not show significant associations with histories of thyroid diseases. Among 14,860 participants without history of thyroid disorders, people having higher CPI values demonstrated higher probabilities of abnormal TFTs (OR 1.381, 95% CI 1.241‒1.537, p <.0001); however, statistical significance was not found after adjusting for the other variables. Conclusions: Our study demonstrated that good oral health‐related behavior was associated with more frequent thyroid disease history. High CPI showed a significant association with TFT abnormalities; however, the significance of this association became lower when other variables such as age and sex were adjusted. Further studies will be needed to determine how the control of oral health‐related conditions actually has a causal relationship with thyroid disease/dysfunction through prospective cohort studies. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Survival Benefits From Surgery for Stage IVa Head and Neck Squamous Cell Carcinoma: A Multi-Institutional Analysis of 1,033 Cases

Author

Park, Jun-Ook, primary, Park, Young Min, additional, Jeong, Woo-Jin, additional, Shin, Yoo Seob, additional, Hong, Yong Tae, additional, Choi, Ik Joon, additional, Kim, Ji Won, additional, Woo, Seung Hoon, additional, Kim, Yeon Soo, additional, Chang, Jae Won, additional, Kim, Min-Sik, additional, Jung, Kwang-Yoon, additional, Ahn, Soon-Hyun, additional, Kim, Chul-Ho, additional, Hong, Ki Hwan, additional, Chung, Phil-Sang, additional, Kim, Young-Mo, additional, Kim, Se-Heon, additional, and Baek, Seung-Kuk, additional

Published
2021
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46. The Utility of Gastrointestinal Endoscopic Examination Versus Positron Emission Tomography–Computed Tomography in the Detection of Second Primary Lesions in Korean Patients With Head and Neck Cancer.

Author

Kim, Min-Su, Song, In Sik, Oh, Kyoung Ho, Cho, Jae-Gu, Baek, Seung-Kuk, Woo, Jeong-Soo, Jung, Kwang-Yoon, and Kwon, Soon Young

Subjects
NASOPHARYNX cancer, COLONOSCOPY, CONFIDENCE intervals, HEAD & neck cancer, DIGESTIVE system endoscopic surgery, POSITRON emission tomography computed tomography, RETROSPECTIVE studies, METASTASIS, TUMOR classification, RISK assessment, SECONDARY primary cancer, DESCRIPTIVE statistics, ENDOSCOPIC gastrointestinal surgery, ODDS ratio, PRECANCEROUS conditions
Abstract

Objective: Head and neck cancer often accompany a synchronous secondary primary lesion in the digestive tract. The aim of this study was to compare detection rates between positron emission tomography–computed tomography (PET-CT) and esophagogastroduodenoscopy (G-fiber) or colonoscopy (C-fiber) in the initial staging and to analyze risk factors for premalignant, malignant, and total synchronous secondary primary lesions. Methods: A total of 739 patients with head and neck cancer who underwent PET-CT, G-fiber, or C-fiber were analyzed retrospectively. Results: Positron emission tomography–CT did not definitely detect any premalignant synchronous secondary primary lesions (0 [0%] of 739) but definitely detected 10 malignant synchronous secondary primary lesions (10 [1.35%] of 739). Esophagogastroduodenoscopy or C-fiber detected all 20 premalignant synchronous secondary primary lesions (20 [2.71%] of 739) and all 37 malignant synchronous secondary primary lesions (37 [5.00%] of 739). The patients with nasopharynx cancer tended to have premalignant synchronous secondary primary lesions (odds ratio [OR]: 3.793; 95% CI: 1.414-10.171; P =.008). Those with distant metastasis tended to have premalignant (OR: 4.743; 95% CI: 1.508-14.916; P =.009), malignant (OR: 3.803; 95% CI: 1.486-9.731; P =.005), and total synchronous secondary primary lesions (OR: 2.753; 95% CI: 1.159-6.538; P =.022). Conclusions: Premalignant or malignant synchronous secondary primary lesions that were not definitely detected by PET-CT could be found in the endoscopic examination. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Effects of N-acetylcysteine inhalation therapy on the quality of life of patients with head and neck cancer who are receiving radiation therapy: a prospective non-randomized controlled multi-center study

Author

Won, Ho-Ryun, primary, Lee, Geon ho, additional, Kim, Jin Hwan, additional, Lee, Sang Hyuk, additional, Kwon, Soon Young, additional, Baek, Seung-Kuk, additional, Ryu, Chang Hwan, additional, Lee, Sang Joon, additional, Park, Il-Seok, additional, Shin, Sung-Chan, additional, Lee, Dong Wook, additional, Chung, Phil-Sang, additional, and Koo, Bon Seok, additional

Published
2020
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