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This study was conducted to assess the holistic needs of cancer patients in terms of physiological, psychological, social, and spiritual needs and to determine how they respond through coping strategies. The study utilized a quantitative descriptive approach as a research design and adapted the Sheffield Profile for Assessment and Referral to Care (SPARC) for holistic need assessment and adopted the Situational Version of the Brief COPE for coping strategies with 14 theoretically coping responses by measuring the 28-item self-report questionnaire. The study includes 20 diagnosed cancer patients from the early stage to stage 3 except for those who were not able to participate due to extensive progression of the disease and those who received palliative treatment. Purposive sampling was used in the selection of the subjects. It was found out that in terms of physiological needs, "Fatigue" is the most common symptom they experienced. In terms of psychological, social, and spiritual needs, most of the patients experienced a significant concern. Meanwhile, in coping, "Religion" dominates among the 14 strategies followed by "Use of Emotional Support" and "Positive Reframing", and, "Substance Use" obtained the lowest response. Most of the respondents were female and its significant relationship in terms of "Positive Reframing" agrees significantly. Moreover, in coping and civil status, "Positive Reframing" and "Humor" are significant among married respondents. In coping and stage of cancer, "Positive Re- framing" and "Humor" are significant with the stage of cancer. In coping and treatment modalities, "Active Coping", "Use of Emotional Support" and "Religion" are significantly related to patients' treatment modalities. There is also a significant relationship between "Active Coping and Physiological Needs"; "Religion and Psychological Needs", and, "Self-blaming and Psychological, Social and Spiritual Needs". Holistic needs and coping strategies are related to one another to achieve the goal of healing & coping. Spirituality & the presence of strong support system manifest a positive coping response in their journey to healing regardless of the stage and diagnosis. A formulated care intervention program "My Cancer Journey" would be beneficial among cancer patients. The paper is written based on scholarly work and all errors has been corrected and followed the appropriate format. The research follows and adopted the appropriate methods of research inquiry. [ABSTRACT FROM AUTHOR]