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3. Chyme reinfusion in a clinical setting.

Author

Steensgaard, Maja, Cooper, Laura, Staub, Ditte, Salling, Ida, and Bager, Palle

Abstract

Background: Patients with ileostomies may develop intestinal failure and high stoma output. Chyme reinfusion (CR) was considered an alternative to parenteral nutrition. The Insides System, a closed system for CR, was introduced to allow complete patient control and management. In this paper the authors used the system for 3 years and aimed to describe its use in clinical practice. Methods: A cohort of patients considered for the system was included in the study. They were followed from screening until discontinuation of the system. Data on health-related quality of life were collected, and journal audits were performed. Results: A total of 14 patients were included in the results. Two did not receive the system, four answered the questionnaires one time or less and four had the system discontinued before discharge. Answers from the remaining four patients were inconclusive. The audit revealed that evaluating patient compliance and motivation was key before introducing the system. With the system in place, pain and discomfort levels were found to be important for the patients. Conclusion: The Insides System was feasible in a clinical practice setting. However, comprehensive screening was necessary, with specialised nurses playing a key role. [ABSTRACT FROM AUTHOR]

Published
2024
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6. e-Health

Author

Bager, Palle, Sturm, Andreas, editor, and White, Lydia, editor

Published
2019
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12. ESPEN guideline on Clinical Nutrition in inflammatory bowel disease

Author

Bischoff, Stephan C., primary, Bager, Palle, additional, Escher, Johanna, additional, Forbes, Alastair, additional, Hébuterne, Xavier, additional, Hvas, Christian Lodberg, additional, Joly, Francisca, additional, Klek, Stansilaw, additional, Krznaric, Zeljko, additional, Ockenga, Johann, additional, Schneider, Stéphane, additional, Shamir, Raanan, additional, Stardelova, Kalina, additional, Bender, Darija Vranesic, additional, Wierdsma, Nicolette, additional, and Weimann, Arved, additional

Published
2023
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13. Intestinal Faecalibacterium Prausnitzii Abundance Correlates With The Effect Of High-Dose Thiamine On Chronic Fatigue In Patients With IBD In Remission

Author

Sanchez, Sandra Bermudez, Bager, Palle, Dahlerup, Jens Frederik, Baunwall, Simon Dahl, Licht, Tine Rask, Mortensen, Martin Steen, Hvas, Christian, Sanchez, Sandra Bermudez, Bager, Palle, Dahlerup, Jens Frederik, Baunwall, Simon Dahl, Licht, Tine Rask, Mortensen, Martin Steen, and Hvas, Christian

Abstract

Gut microbiome analysis in previous studies has shown that IBD patients with fatigue symptoms were characterized by a significant reduction in butyrate-producing bacteria in the colon and a less diverse microbiome. Although some gut bacteria can produce thiamine in the gut environment, many butyrate-producing bacteria, including Faecalibacterium prausnitzii, appear to depend on dietary thiamine or cross-feeding from other bacterial species in the colon. In some situations, a lack of thiamine in the colon may thus reduce the number of butyrate-producing bacteria, and thereby butyrate levels in the colon. Recently, a randomized, double-blinded, placebo-controlled crossover trial revealed that high-dose oral thiamine significantly reduced chronic fatigue in IBD patients in remission. Here, we analyzed the microbiota and short-chain fatty acids concentrations in fecal samples from that study to test the possibility that the beneficial effect of thiamine on chronic fatigue was explained by induced changes in the microbiome, including increased levels of butyrate-producing bacteria and butyrate. However, we found no differences in butyrate nor butyrate-producing bacteria between controls and chronic fatigue patients or during the treatment by comparing placebo vs. treated patients. Interestingly, a negative correlation between F. prausnitzii relative abundance in fecal samples and IBD fatigue score change was seen in thiamine-treated patients with chronic fatigue.

Published
2023

19. Levercirrose

Author

Bager, Palle, Have, Heidi, Wensien, Jette, and Grønhøj, Mads

Published
2022

20. Hepatisk encefalopati

Author

Bager, Palle, Have, Heidi, Wensien, Jette, and Grønhøj, Mads

Published
2022

21. Crohns sygdom

Author

Bager, Palle, Have, Heidi, Wensien, Jette, and Grønhøj, Mads

Published
2022

22. Colitis ulcerosa

Author

Bager, Palle, Have, Heidi, Wensien, Jette, and Grønhøj, Mads

Published
2022

25. Patient-reported outcomes and health-related quality of life in people living with ileostomies: A population-based, cross-sectional study

Author

Rud, Charlotte L, Baunwall, Simon Mark Dahl, Bager, Palle, Dahlerup, Jens Frederik, Wilkens, Trine L, Tøttrup, Anders, Lal, Simon, Hvas, Christian Lodberg, Rud, Charlotte L, Baunwall, Simon Mark Dahl, Bager, Palle, Dahlerup, Jens Frederik, Wilkens, Trine L, Tøttrup, Anders, Lal, Simon, and Hvas, Christian Lodberg

Abstract

Background: The impact of a stoma on long-term health-related quality of life in people living with ileostomies is not clear. Objective: This study aimed to describe important patient-reported outcomes and health-related quality of life in people with ileostomies. Design: This is a population-based, cross-sectional study. Patients were invited to answer questionnaires estimating stoma-specific and generic health-related quality of life (EQ-5D-5L and the Major Depression Inventory). Danish norms were retrieved from reference literature. Settings: This study was conducted at the major stoma clinic at Aarhus University Hospital, Denmark. Patients: We invited all patients with ileostomies who were in contact with the clinic between 2012 and 2017. Main outcome measures: The primary outcomes measured were patient-reported outcomes specific to people with ileostomies. Results: Of 621 identified patients (50% women), 412 (67%) responded to the survey. Among the responders, 178 (43%) reported that they still had an ileostomy at the time of the survey and were included in the analysis. Fatigue was frequent; 68% (95% CI 60%-75%) reported being tired and 26% (95% CI 20%-33%) answered that they were "always tired," whereas 43% (95% CI 36%-51%) lacked energy, 62% (95% CI 54%-69%) reported poor sleep, and 59% (95% CI 52%-66%) needed to rest during the day. Fifty-six percent (95% CI 48%-63%) needed to know the immediate location of the nearest toilet, and 58% (95% CI 51%-66%) felt sexually unattractive because of their ileostomy. Health-related quality of life measured with generic questions indicated 0.124 points lower health-related quality of life than the Danish norm (p < 0.001), and 18% (95% CI 13%-25%) scored above the threshold for depression, which is 2.6 times higher than the background population (7%, 95% CI 6%-9%; p < 0.001). Limitations: This study was limit

Published
2022

27. ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment

Author

Adamina, Michel, Bonovas, Stefanos, Raine, Tim, Spinelli, Antonino, Warusavitarne, Janindra, Armuzzi, Alessandro, Bachmann, Oliver, Bager, Palle, Biancone, Livia, Bokemeyer, Bernd, Bossuyt, Peter, Burisch, Johan, Collins, Paul, Doherty, Glen, El-Hussuna, Alaa, Ellul, Pierre, Fiorino, Gionata, Frei-Lanter, Cornelia, Furfaro, Federica, Gingert, Christian, Gionchetti, Paolo, Gisbert, Javier P, Gomollon, Fernando, Lorenzo, Marien Gonzalez, Gordon, Hannah, Hlavaty, Tibor, Juillerat, Pascal, Katsanos, Konstantinos, Kopylov, Uri, Krustins, Eduards, Kucharzik, Torsten, Lytras, Theodore, Maaser, Christian, Magro, Fernando, Marshall, John Kenneth, Myrelid, Par, Pellino, Gianluca, Rosa, Isadora, Sabino, Joao, Savarino, Edoardo, Stassen, Laurents, Torres, Joana, Uzzan, Mathieu, Vavricka, Stephan, Verstockt, Bram, Zmora, Oded, Akyuz, Filiz, Atreya, Raja, De Acosta, Manuel Barreiro, Bettenworth, Dominik, Bjorkesten, Clas-Goran, Bogut, Ante, Calabrese, Emma, Cvetkovic, Mirjana, Dewint, Pieter, Djuranovic, Srdjan, Drobne, David, Duricova, Dana, Filippi, Jerome, Hogenauer, Christoph, Kaimakliotis, Ioannis, Kiudelis, Gediminas, Klopocka, Maria, Koutroubakis, Ioannis, Krznaric, Zeljko, Laja, Hendrik, Moschen, Alexander, Novak, Gregor, Potapov, Alexander, Tuire, Ilus, Turcan, Svetlana, van Dop, Willemijn, van Schaik, Fiona, Vieira, Ana Isabel, Viennot, Stephanie, Wildt, Signe, Adamina, Michel, Bonovas, Stefano, Raine, Tim, Spinelli, Antonino, Warusavitarne, Janindra, Armuzzi, Alessandro, Bachmann, Oliver, Bager, Palle, Biancone, Livia, Bokemeyer, Bernd, Bossuyt, Peter, Burisch, Johan, Collins, Paul, Doherty, Glen, El-Hussuna, Alaa, Ellul, Pierre, Fiorino, Gionata, Frei-Lanter, Cornelia, Furfaro, Federica, Gingert, Christian, Gionchetti, Paolo, Gisbert, Javier P, Gomollon, Fernando, Lorenzo, Marien González, Gordon, Hannah, Hlavaty, Tibor, Juillerat, Pascal, Katsanos, Konstantino, Kopylov, Uri, Krustins, Eduard, Kucharzik, Torsten, Lytras, Theodore, Maaser, Christian, Magro, Fernando, Marshall, John Kenneth, Myrelid, Pär, Pellino, Gianluca, Rosa, Isadora, Sabino, Joao, Savarino, Edoardo, Stassen, Laurent, Torres, Joana, Uzzan, Mathieu, Vavricka, Stephan, Verstockt, Bram, Zmora, Oded, Surgery, MUMC+: MA Heelkunde (9), MUMC+: MA AIOS Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Adamina M., Bonovas S., Raine T., Spinelli A., Warusavitarne J., Armuzzi A., Bachmann O., Bager P., Biancone L., Bokemeyer B., Bossuyt P., Burisch J., Collins P., Doherty G., El-Hussuna A., Ellul P., Fiorino G., Frei-Lanter C., Furfaro F., Gingert C., Gionchetti P., Gisbert J.P., Gomollon F., Gonzalez Lorenzo M., Gordon H., Hlavaty T., Juillerat P., Katsanos K., Kopylov U., Krustins E., Kucharzik T., Lytras T., Maaser C., Magro F., Marshall J.K., Myrelid P., Pellino G., Rosa I., Sabino J., Savarino E., Stassen L., Torres J., Uzzan M., Vavricka S., Verstockt B., and Zmora O.

Subjects
Crohn’s disease, intersphincteric fistula tract, pouch-anal anastomosis, inflammatory bowel disease [IBD], FECAL DIVERSION, Disease, Inflammatory bowel disease, surgery, vedolizumab-treated patients, Crohn Disease, Maintenance therapy, Induction therapy, Intestine, Small, EVIDENCE-BASED CONSENSUS, Medicine, POSTOPERATIVE COMPLICATIONS, Certolizumab pegol, 610 Medicine & health, Surgical treatment, POUCH-ANAL ANASTOMOSIS, TO-END ANASTOMOSIS, Crohn's disease, Gastroenterology, ANTI-TNF THERAPY, General Medicine, Inflammatory bowel disease (IBD), Life Sciences & Biomedicine, medicine.drug, medicine.medical_specialty, Abdominal Abscess, MEDLINE, postoperative complications, Humans, Rectal Fistula, INTRAABDOMINAL SEPTIC COMPLICATIONS, Intensive care medicine, VEDOLIZUMAB-TREATED PATIENTS, Science & Technology, evidence-based consensus, Gastroenterology & Hepatology, inflammatory-bowel-disease, intraabdominal septic complications, business.industry, medicine.disease, INTERSPHINCTERIC FISTULA TRACT, business, Intestinal Obstruction, INFLAMMATORY-BOWEL-DISEASE
Abstract

This article is the second in a series of two publications relating to the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease. The first article covers medical management; the present article addresses surgical management, including preoperative aspects and drug management before surgery. It also provides technical advice for a variety of common clinical situations. Both articles together represent the evidence-based recommendations of the ECCO for Crohn's disease and an update of previous guidelines. ispartof: JOURNAL OF CROHNS & COLITIS vol:14 issue:2 pages:155-168 ispartof: location:England status: published

Published
2019

32. Fatigue and quality of life in patients with neuroendocrine neoplasia.

Author

Hummelshøj, Nynne Emilie, Gronbaek, Henning, Bager, Palle, Tabaksblat, Elizaveta, and Dam, Gitte

Subjects
FATIGUE life, NEUROENDOCRINE tumors, OLDER patients, CANCER fatigue, TUMORS, QUALITY of life, TRAIL Making Test
Abstract

Neuroendocrine Neoplasms (NEN) are rare tumours arising in the gastro-intestinal tract or lungs. Poor health related quality of life (HRQoL) is associated with the carcinoid syndrome (CS), but fatigue is also important. We aimed to quantify HRQoL and fatigue in out-patients with NEN. In a cross-sectional study, we included 231 patients with NEN (G1-G3). We used pre-validated questionnaires MFI-20, EQ-5D-5L and 85% responded. We collected clinical, biochemical, imaging, and pathology data from Electronic Patient files. Normative values for fatigue and HRQoL were derived from background populations. Median age was 68 years (range 21–91) and 52% were male. Patients with NEN reported more fatigue and worse HRQoL compared to the background population (p <.05). Cured patients reported higher HRQoL than patients with current disease, and patients with high grade neoplasms (G2–G3) reported more anxiety and depression compared to patients with low grade G1 disease (p <.05). The CS resulted in a 9% relative loss in Quality Adjusted Life Years compared to patients without CS. (p <.05). More than 50% of patients with CS reported problems with usual activities, pain/discomfort, and anxiety/depression. Overall, 36% of patients with NEN were fatigued and 92% of these had psychological fatigue. Younger patients (<65 years) experienced more fatigue than older patients (p <.05). Patients with NEN report significantly lower HRQoL and more fatigue compared to the background population. Especially, patients with CS had pain, discomfort, anxiety, and depression and a relative reduction in HRQoL. However, compared to other cancer types, patients with NEN experience less fatigue. [ABSTRACT FROM AUTHOR]

Published
2023
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44. ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment

Author

Adamina, Michel, Bonovas, Stefanos, Raine, Tim, Spinelli, Antonino, Warusavitarne, Janindra, Armuzzi, Alessandro, Bachmann, Oliver, Bager, Palle, Biancone, Livia, Bokemeyer, Bernd, Bossuyt, Peter, Burisch, Johan, Collins, Paul, Doherty, Glen, El-Hussuna, Alaa, Ellul, Pierre, Fiorino, Gionata, Frei-Lanter, Cornelia, Furfaro, Federica, Gingert, Christian, Gionchetti, Paolo, Gisbert, Javier P, Gomollon, Fernando, González Lorenzo, Marien, Gordon, Hannah, Hlavaty, Tibor, Juillerat, Pascal, Katsanos, Konstantinos, Kopylov, Uri, Krustins, Eduards, Vavricka, S, University of Zurich, and Adamina, Michel

Subjects
10219 Clinic for Gastroenterology and Hepatology, 610 Medicine & health, 2715 Gastroenterology
Published
2020

45. ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment

Author

Torres, Joana, Bonovas, Stefanos, Doherty, Glen, Kucharzik, Torsten, Gisbert, Javier P, Raine, Tim, Adamina, Michel, Armuzzi, Alessandro, Bachmann, Oliver, Bager, Palle, Biancone, Livia, Bokemeyer, Bernd, Bossuyt, Peter, Burisch, Johan, Collins, Paul, El-Hussuna, Alaa, Ellul, Pierre, Frei-Lanter, Cornelia, Furfaro, Federica, Gingert, Christian, Gionchetti, Paolo, Gomollon, Fernando, González-Lorenzo, Marien, Gordon, Hannah, Hlavaty, Tibor, Juillerat, Pascal, Katsanos, Konstantinos, Kopylov, Uri, Krustins, Eduards, Lytras, Theodore, et al, and University of Zurich

Subjects
10219 Clinic for Gastroenterology and Hepatology, 610 Medicine & health, 2715 Gastroenterology
Published
2020

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