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20. Osteoporosi: stile di vita e farmaci

Author

Bacchi Modena, A, Bagni, B, De Aloysio, D, Giulini, N, Pansini, Fs, Volpe, Annibale, Aldrigo, A, Arangino, S, Bergamini, C, Fontanesi, V, Gabbi, D, Generali, Matteo, Malmusi, S, Vultaggio, E, and Cagnacci, Angelo

Subjects
osteoporosi
Published
2008

24. Circadian rhythms of atrial natriuretic peptide, renin, aldosterone, cortisol, blood pressure and heart rate in normal and hypertensive subjects

Author

M. Ferlini, Parti M, Angelo Margutti, Francesco Portaluppi, degli Uberti E, L Montanari, Maria Teresa Zanella, Giorgio Trasforini, Cavallini R, and Bagni B

Subjects
Male, Cosinor analysis, Sodium balance, medicine.medical_specialty, Hydrocortisone, Physiology, Heart rate, Rennin, Essential hypertension, Plasma renin activity, Cortisol, chemistry.chemical_compound, Atrial natriuretic peptide, Internal medicine, Renin, Internal Medicine, medicine, Humans, Adult hospitalized humans, Circadian rhythm, Aldosterone, Chronobiology, business.industry, Middle Aged, Blood pressure, medicine.disease, Endocrinology, chemistry, Hypertension, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business, Atrial Natriuretic Factor, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology, Blood sampling
Abstract

The occurrence and extent of a circadian rhythm in the circulating concentrations of atrial natriuretic peptide (ANP) are still matters of controversy. Only a few data are available in humans relating the time structure of plasma ANP levels with the circadian patterns of other hormones and cardiovascular variables. In a group of hospitalized normal volunteers (six men and four women, 16-76 years old), and in a group of hospitalized hypertensives (seven men and three women, 18-76 years old), we investigated the circadian variability of ANP and its temporal relationship with the circadian rhythms of blood pressure (BP) and heart rate (HR), and plasma renin activity (PRA), plasma aldosterone (PA) and plasma cortisol (PC) levels, by using a chronobiological inferential statistic method. At the end of a synchronizing period of 1 week (the diet and daily schedule were standardized), the subjects underwent automatic BP and HR monitoring, and blood sampling for 24 h. A statistically significant mean circadian rhythm was demonstrated for ANP, BP, HR, PRA, PA and PC in both normal and hypertensive subjects. The mean circadian acrophase of ANP (calculated to occur at around 04.00 h) anticipated the corresponding acrophases of the other hormones; BP and HR rhythms appeared to be in antiphase with ANP rhythm, i.e. the peak of BP and HR rhythms more or less coincided with the trough in ANP rhythm. A significant increase in the daily levels (assessed by the circadian mesor) of ANP was present in hypertensive subjects when compared with normal controls. In essential hypertension the circadian rhythm of ANP was set at higher circulating levels, but otherwise it was similar to the circadian rhythm found in normals. ANP mesors correlated significantly with renin and aldosterone mesors in normal subjects but not in hypertensive patients. ANP appears to anticipate awakening in its circadian periodic rise. On the basis of the considerable acrophase asynchronism, it seems possible to exclude any causal relations between the periodic changes of ANP and the rhythmic fluctuations of the other hormones that we studied. In contrast, important relations may be hypothesized between ANP levels and BP and HR values, on the basis of their antiphase rhythms.

Published
1990

25. Osteoporosi e Malattie Metaboliche dell’osso. Compendio Clinico-Diagnostico

Author

Adami, S, Bagni, B, Bianchi, Ml, Bonucci, E, Brandi, Ml, Cannella, C, Caudarella, R, Corazzari, T, D’Erasmo, E, Di Munno, O, Faletti, C, Fiore, Ce, Gennari, L, Gonnelli, S, Isaia, Giovanni Carlo, Luisetto, G, Martini, G, Masciocchi, C, Mazzaferro, S, Minisola, S, Nuti, R, Passeri, M, Postacchini, M, Santilli, V, Teti, A, and Zallone, A.

Published
2006

41. Hypoparathyroidism in chronic alcohol intoxication: a preliminary report

Author

Roberto Manfredini, Bariani L, Bagni B, Ar, Cavallini, Gallerani M, Salmi R, Pasin M, Cecchetti E, Rosini M, and Franceschini F

Subjects
Adult, Male, Alcoholism, Hypoparathyroidism, Parathyroid Hormone, Humans, Female, Middle Aged
Abstract

It is well known that osteoporosis is more common in chronic alcoholists than in age-matched controls. Possible aetiological factors could be: malabsorption of calcium and vitamin D, liver disease, abnormal parathyroid function. With this study, the authors investigated parathyroid hormone (PTH) behaviour in thirteen selected patients with alcohol abuse, free from any clinical or humoral sign of hepatopathy, and in ten healthy subjects as a control group. In alcohol abusers a significant reduction of plasmatic PTH, compared to normal calcium levels were found. A possible direct interaction effect between ethyl alcohol and PTH may be suggested, even if further studies are required.

Published
1992

42. Predictive role of fluorodeoxyglucose positron emission tomography (18 fF-FDG CT-PET) in early assessment of response to bevacizumab and FOLFOX-6 combined neoadjuvant therapy for liver metastasis (LM) from colorectal cancer (CRC)

Author

Malavasi, N., primary, Bagni, B., additional, Bertolini, F., additional, Dealis, C., additional, Depenni, R., additional, Cucca, M., additional, Casolo, A., additional, Ponti, G., additional, Luppi, G., additional, and Conte, P. F., additional

Published
2008
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