Author: "Bahamonde Carrasco, Alberto" - Searchworks@Jio Institute Digital Library Search Results

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1. Early antibiotic de-escalation in patients with severe infections due to bloodstream infection by enterobacterales: A post hoc analysis of a prospective multicentre cohort

Author: Retamar-Gentil, Pilar, Ferrer, José Bravo, García, Marcos Guzmán, García, David Vinuesa, Gea-Lázaro, Isabel, Natal, Isabel Fernández, Porto, Antonio Sánchez, Pérez-Camacho, Inés, León, Eva, de Lucas, Esperanza Merino, Fariñas, Maria Carmen, Reche, Isabel, Escrihuela-Vidal, Francesc, Palacios-Baena, Zaira R., Agirre, Josune Goikoetxea, Pérez-Rodríguez, María Teresa, Reguera Iglesias, José María, Cuquet Pedragosa, Jordi, Sánchez Gómez, Leticia, Boix-Palop, Lucía, Bahamonde Carrasco, Alberto, Natera-Kindelán, Clara, Fernández-Suárez, Jonathan, Jover-Sáenz, Alfredo, Smithson Amat, Alejandro, del Arco Jiménez, Alfonso, Sánchez Calvo, Juan Manuel, Martín-Aspas, Andrés, Martínez Pérez-Crespo, Pedro María, López-Hernández, Inmaculada, Rodríguez-Baño, Jesús, and López-Cortés, Luis Eduardo
Published: 2024
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2. Clinical characteristics, predisposing factors and outcomes for Enterococcus faecalis versus Enterococcus faecium bloodstream infections: a prospective multicentre cohort study.

Author: Scharloo, Fenna, Cogliati Dezza, Francesco, López-Hernández, Inmaculada, Martínez Pérez-Crespo, Pedro María, Goikoetxea Aguirre, Ane Josune, Pérez-Rodríguez, María Teresa, Fernandez-Suarez, Jonathan, León Jiménez, Eva, Morán Rodríguez, Miguel Ángel, Fernández-Natal, Isabel, Reguera Iglesias, José María, Natera Kindelán, Clara, Fariñas Álvares, Maria Carmen, Boix-Palop, Lucía, Lopez-Cortes, Luis Eduardo, Rodríguez-Baño, Jesús, Jover-Sáenz, Alfredo, Sánchez-Calvo, Juan Manuel, Gea-Lázaro, Isabel, and Bahamonde Carrasco, Alberto
Subjects: ENTEROCOCCUS faecalis, ENTEROCOCCUS faecium, CONGESTIVE heart failure, HOSPITAL mortality, DEATH rate, ENTEROCOCCAL infections
Abstract: Purposes: Enterococcal BSI is associated with significant morbidity and mortality, with fatality rates of approximately 20–30%. There are microbiological and clinical differences between E. faecalis and E. faecium infections. The aim of this study was to investigate differences in predisposing factors for E. faecalis and E. faecium BSI and to explore prognostic factors. Methods: This study was a post-hoc analysis of PROBAC, a Spanish prospective, multicenter, cohort in 2016–2017. Patients with E. faecalis or E. faecium BSI were eligible. Independent predictors for BSI development in polymicrobial and monomicrobial BSI and in-hospital mortality in the monomicrobial group were identified by logistic regression. Results: A total of 431 patients were included. Independent factors associated with E. faecium BSI were previous use of penicillins (aOR 1.99 (95% CI 1.20–3.32)) or carbapenems (2.35 (1.12–4.93)), hospital-acquired BSI (2.58 (1.61–4.12)), and biliary tract source (3.36 (1.84–6.13)), while congestive heart failure (0.51 (0.27–0.97)), cerebrovascular disease (0.45 (0.21–0.98)), and urinary tract source (0.49 (0.26–0.92)) were associated with E. faecalis BSI. Independent prognostic factors for in-hospital mortality in E. faecalis BSI were Charlson Comorbidity Index (1.27 (1.08–1.51)), SOFA score (1.47 (1.24–1.73)), age (1.06 (1.02–1.10)), and urinary/biliary source (0.29 (0.09–0.90)). For E. faecium BSI, only SOFA score (1.34 (1.14–1.58) was associated with in-hospital mortality. Conclusions: The factors associated with E. faecium and E. faecalis BSI are different. These variables may be helpful in the suspicion of one or other species for empiric therapeutic decisions and provide valuable information on prognosis. [ABSTRACT FROM AUTHOR]
Published: 2024
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3. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study

Author: Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, Retamar, Pilar, Valiente, Adoración, López-Cortés, Luis E., Sojo-Dorado, Jesús, Bravo-Ferrer, José, Salamanca, Elena, Palacios-Baena, Zaira R., Pérez-Palacios, Patricia, Gandullo-Moro, María, Ruíz-Hueso, Rocío, Moya-González, Natalia, Valido-Morales, Agustín, Pavón-Masa, María, Díaz Menéndez, Marta, De la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, De Miguel Buckley, Rosa, Cadiñanos Loidi, Julen, Busca Arenzana, Carmen, Mican Rivera, Rafael, Mora Rillo, Marta, Loeches Yagüe, Belén, Bernardino de la Serna, José Ignacio, García Rodríguez, Julio, Montejano Sánchez, Rocío, Diaz Pollan, Beatriz, López, Juan Carlos, Ramírez-Schacke, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Parras, Francisco, Catalán, Pilar, García-Leoni, María E, Pérez-Tamayo, Isabel, Puente, Luis, Cedeño, Jamil, Such-Diaz, Ana, Álvaro-Alonso, Elena, Izquierdo-García, Elsa, Torres-Macho, Juan, Cuevas, Guillermo, Notario, Helena, Mestre-Gómez, Beatriz, Jiménez-González de Buitrago, Eva, Fernández-Jiménez, Inés, Tebar-Martínez, Ana Josefa, Brañas, Fátima, Valencia, Jorge, Pérez-Butragueño, Mario, Alvarado, Marta, Abelenda-Alonso, Gabriela, Ardanuy, Carmen, Bergas, Alba, Cuervo, Guillermo, Domínguez, María Ángeles, Fernández-Huerta, Miguel, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Pérez-Recio, Sandra, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Trullen, Núria, Cisneros, José Miguel, Amodeo, Cristina, Camacho, Pedro, Espinosa, Nuria, García-Gutiérrez, Manuel, Jara-Palomares, Luis, González-León, Rocío, Molina, José, Nieto Martín, María Dolores, Paniagua, María, Poyato, Manuel, Rodríguez-Villodres, Ángel, Ruiz de Azua, Zaida, Salamanca, Celia, Sepúlveda Berrocal, Mº Antonia, Yera Bergua, Carmen, Toledano Sierra, Pilar, Cano Llorente, Verónica, Zafar Iqubal-Mirza, Sadaf, Muñiz, Gema, Martín Pérez, Inmaculada, Mozas Moriñigo, Helena, Alguacil, Ana, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Goikoetxea Agirre, Josune, Blanco Vidal, María José, Nieto Arana, Javier, del Álamo Martínez de Lagos, Mikel, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Silvariño Fernández, Rafael, Ugalde Espiñeira, Jon, Rivas-Carmenado, María, Suárez Pérez, Lucia, Suárez Diaz, Silvia, Yllera Gutiérrez, Carmen, Boix, Vicente, Díez Martínez, Marcos, Carreres Candela, Melissa, Gómez-Ayerbe, Cristina, Sánchez-Lora, Javier, Velasco Garrido, José Luis, López-Jodar, María, Santos González, Jesús, Ruiz Aragón, Jesús, Virto Peña, Ianire, Alende Castro, Vanessa, Sande Llovo, Diana, Vega Molpeceres, Sonia, Pons Viñas, Estel, del Río Pérez, Oscar, Valero Rovira, Silvia, Villar-García, Judit, Gómez-Junyent, Joan, Cánepa, María Cecilia, Castañeda Espinosa, Silvia, Letang, Emilio, Arenas-Miras, María del Mar, Gómez-Zorrilla, Silvia, Sánchez Martínez, Francesca, Lerma-Chippirraz, Elisabet, García Vázquez, Elisa, Moral Escudero, Encarnación, Roura Piloto, Aychel Elena, García Almodóvar, Esther, Sáez Barberá, Carmen, Karroud, Zineb, Hernández Quero, José, Vinuesa García, David, García Fogeda, José Luis, Peregrina, José Antonio, Novella Mena, María, Hernández Gutiérrez, Cristina, Sanz Moreno, José, Pérez Tanoira, Ramón, Navarro López, Jorge, Balsa Vázquez, Javier, Gutiérrez García, Aida, Arranz Caso, Alberto, Cuadros González, Juan, Álvarez de Mon Soto, Melchor, Díaz De Brito Fernández, Vicente Ferrer, Sanmarti Vilamala, Montserrat, Gabarrell Pascuet, Aina, Molina Morant, Daniel, España Cueto, Sergio, Cámara Fernández, Jonathan, Sabater Gil, Albert, Muñoz López, Laura, Jorge García, Ruth, Molina Torres, Nora, Sempere Alcocer, Marco Antonio, De Castro Vega, Francisco Javier, De los Santos Gil, Ignacio, García-Fraile, Lucio, Sampedro Núñez, Miguel, Barrios Blandino, Ana, Rodríguez Franco, Carlos, Useros Brañas, Daniel, Villa Martí, Almudena, Oliver Ortega, Javier, Costanza Espiño Álvarez, Alexia, Sanz Sanz, Jesús, Rexach Fumaña, María, Policarpo Torres, Guillem, Ortega Montoliu, Meritxell, Sala Jofre, Clara, Casas Rodríguez, Susana, Tortajada Alamilla, Cecilia, Oltra, Carmina, Masiá Canuto, Mar, Gutiérrez Rodero, Félix, Oltra Sempere, María Rosa, Vela Berna, Sara, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, De la Vega, Alexandra, Pérez Pinto, Sergio, Hernández Machín, Pilar, Alastrué Violeta, Alba, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Gozalo, Mónica, Mora Gómez, Francisco, Milagro Beamonte, Ana, Latorre-Millán, Miriam, Rezusta López, Antonio, Martínez Sapiña, Ana, Meije, Yolanda, Ribera Puig, Alba, Ortega Enciso, Lucía, Sanz Salvador, Xavier, Losa García, Juan Emilio, Velasco Arribas, María, Pérez-Rodríguez, M. Teresa, Pérez González, Alexandre, Belhassen-García, Moncef, Rodríguez-Alonso, Beatriz, López-Bernus, Amparo, Carbonell, Cristina, Torres Perea, Rafael, Cantón De Seoane, Juan, Alonso, Blanca, Kamal, Sara Lidia, Cajuela, Lucía, Roa, David, Cervero, Miguel, Oreja, Alberto, Avilés, Juan Pablo, Martín, Lidia, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Abadia Otero, Jésica, Salillas Hernando, Juan, Torres Sánchez del Arco, Robert, Torralba González de Suso, Miguel, Serrano Martínez, Alberto, Gilaberte Reyzábal, Sergio, Pacheco Martínez-Atienza, Marina, Liébana Gómez, Mónica, Fernández Rodríguez, Sara, Varela Plaza, Álvaro, Calvo Sánchez, Henar, Martínez Martín, Patricia, González- Ruano, Patricia, Malmierca Corral, Eduardo, Rábago Lorite, Isabel, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Sirisi, Merce, Rojas, Richard, Díaz de Tuesta del Arco, José Luis, Figueroa Cerón, Ruth, González Sarria, Ander, Alemán Valls, Remedios, Alonso Socas, María del Mar, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Riera Jaume, Melchor, Vilchez, Helem Haydee, Albertí, Francesc, Cañabate, Ana Isabel, Moreno Cuerda, Víctor J, Álvarez Kaelis, Silvia, Álvarez Zapatero, Beatriz, García García, Alejandro, Isaba Ares, Elena, Morcate Fernández, Covadonga, Pérez Rodríguez, Andrea, Ramos Merino, Lucía, Castelo Corral, Laura, Rodríguez Mahía, María, González Bardanca, Mónica, Sánchez Vidal, Efrén, Míguez Rey, Enrique, Correa Ruiz, Ana, García de Lomas Guerrero, José Mº, Daniel López, Daniel, Marinas, Rebeca, Morando, Marta, Gómez García, Lucía, Boix Palop, Lucia, Dietl Gómez-Luengo, Beatriz, Pedrola Gorrea, Iris, Blasco Claramunt, Amparo, López Mestanza, Cristina, Fraile Villarejo, Esther, Jaén Sánchez, Nieves, Orihuela Martín, Jorge, Algado Rabasa, José Tomas, Garijo Saiz, Ana María, Amador Prous, Concepción, Salavert Lletí, Miguel, Hernández Belmonte, Adriana, Martínez Goñi, Raquel, Navarro Vilasaró, Marta, Calzado Isbert, Sonia, Cervantes García, Manuel, Gomila Grange, Aina, Gasch Blasi, Oriol, Machado Sicilia, María Luisa, Van den Eynde Otero, Eva, Falgueras López, Luis, Navarro Sáez, María del Carmen, Martínez, Esteban, Marcos, Mº Ángeles, Mosquera, Mar, Blanco, José Luis, Laguno, Montserrat, Rojas, Jhon, González-Cordón, Ana, Inciarte, Alexy, Torres, Berta, De la Mora, Lorena, Soriano, Alex, Martínez Macia, Olalla, Pérez Doñate, Virginia, Cabello Úbeda, Alfonso, Carrasco Antón, Nerea, Álvarez Álvarez, Beatriz, Petkova Saiz, Elizabet, Górgolas Hernández-Mora, Miguel, Prieto Pérez, Laura, Carrillo Acosta, Irene, Heili Frades, Sara, Villar Álvarez, Felipe, Fernández Roblas, Ricardo, Sánchez Pernaute, Olga, Fernández Espinilla, Virginia, Castrodeza Sanz, José Javier, Dueñas Gutiérrez, Carlos Jesús, González-Romo, Fernando, Merino Amador, Paloma, Rueda López, Alba, Martínez Jordán, Jorge, Medrano Pardo, Sara, Díaz de la Torre, Irene, Posada Franco, Yolanda, Delgado-Iribarren, Alberto, López-Contreras González, Joaquín, Pascual Alonso, Pablo, Pomar Solchaga, Virginia, Rabella García, Nuria, Benito Hernández, Natividad, Domingo Pedrol, Pere, Bonfill Cosp, Xavier, Padrós Selma, Rafael, Puig Campmany, Mireia, Mancebo Cortés, Jordi, Gurguí Ferrer, Mercè, Íñigo Pestaña, Melania, Pérez García, Alejandra, Sorní Moreno, Patricia, Izko Gartzia, Nora, Membrillo de Novales, Francisco Javier, Simón Sacristán, María, Zamora Cintas, Maribel, Martínez Martínez, Yolanda, Estébanez Muñoz, Miriam, Ramírez-Olivencia, Germán, Herrero Mendoza, María Dolores, De Dios García, Begoña, Mata Forte, Tatiana, Rodríguez Fernández, José María, Sáez de Adana Arróniz, Ester, Portu Zapirain, Joseba, Gainzarain Arana, Juan Carlos, Ortiz de Zárate Ibarra, Zuriñe, Moran Rodríguez, Miguel Ángel, Canut Blasco, Andrés, Hernáez Crespo, Silvia, Sanjosé Muñiz, Irene, Molina Iturritza, Estíbaliz, Ganchegui Aguirre, Maite, Urrestarazu Larrañag, Miren, De la Higuera Arranz, Carmen, Álvarez Padín, Pilar, Iglesias Llorente, Laura, Román Bernal, Berta, Sánchez Montalvá, Adrián, Espinosa Pereiro, Juan, Almirante, Benito, Miarons, Marta, Sellarés, Júlia, Larrosa, María, Villamarín, Miguel, Fernández, Nuria, Salvador, Fernando, Bosch-Nicolau, Pau, Pérez-Jorge Peremarch, Conchita, Resino Foz, Elena, Espigares Correa, Andrea, Álvarez de Espejo Montiel, Teresa, Navas Clemente, Iván, Quijano Contreras, María Isabel, Nieto Fernández del Campo, Luis Alberto, Jiménez Álvarez, Guillermo, Guillamón Sánchez, Mercedes, García García, Josefina, Muñoz Hornero, Constanza, Cosmen Sánchez, Ana, Mariño Callejo, Ana, Valcarce Pardeiro, Nieves, Smithson Amat, Alex, Chico Chumillas, Cristina, Sánchez Serrano, Adriana, Piñar Cabezos, Diana, Jiménez Martínez, Isabel, Estrada Fernández, Guillermo, Lorén Vargas, María, Parra Arribas, Nuria, Martínez Cilleros, Carmen, Villasante de la Puente, Aránzazu, García Delange, Teresa, Ruiz Rodríguez, María José, Robledo del Prado, Marta, Abad Almendro, Juan Carlos, Muñoz del Rey, José Román, Jiménez Álvaro, Montaña, Coy Coy, Javier, Poquet Catala, Inmaculada, Santos Peña, Marta, Mora Delgado, Juan, Manso Gómez, Tamara, Rubio Obanos, Teresa, Barbeito Castiñeiras, Gema, Domínguez Santalla, María Jesús, Mao Martín, Laura, Adalid Moll, María, Díaz Luperena, Javier, Ruiz Grinspan, Martín Sebastián, Barrós González, Raquel, Herrera Pacheco, Lourdes, Martínez Avilés, Rocío, Rodrigo González, Sara, Rodríguez Leal, Cristóbal Manuel, Romay Lema, Eva María, Suárez Gil, Roi, Bustinduy Odriozola, Maria Jesús, Marimón Ortiz de Zárate, José María, Vidaur Tello, Loreto, Kortajarena Urkola, Xabier, Arriola Martínez, Paula, Lartategi Iraurgi, Alazne, Álvarez de Castro, Maria, Martínez Mateu, Cintia María, Rodríguez Gómez, Francisco, Asschert Agüero, Isabel, Chamarro Martí, Elena, Franch Llasat, Diego, Zakariya-Yousef Breval, Ismail, Rico Rodríguez, Marta, Martínez López, Belén, García-López, María, Fernández Cruz, Ana, Calderón Parra, Jorge, Ramos Martínez, Antonio, Múñez Rubio, Elena, Vázquez Comendador, José Manuel, Diego Yagüe, Itziar, Expósito Palomo, Esther, Díaz de Santiago, Alberto, De la Fuente Moral, Sara, Pintos Pascual, Ilduara, Álvarez Franco, Raquel, Fernández de Orueta, Lucía, Vates Gómez, Roberto, Cardona Arias, Andrés Felipe, Marguenda Contreras, Pablo, Gaspar Alonso-Vega, Gabriel, Aranda Rife, Elena María, Martínez Cifre, Blanca, Roger Zapata, Daniel, Martín Rubio, Irene, Barbosa Ventura, André, Piñero, Iván, Bahamonde Carrasco, Alberto, Martínez Vidal, Ana, Talavera García, Eva, Mendoza Roy, Paula, Urrutia Losada, Ainhoa, Arteche Eguizabal, Lorea, Delgado Sánchez, Elisabet, Bañón Escandell, Sara, Caro Bragado, Sarah, Domínguez de Pablos, Gema, Herrero Rodríguez, Carmen, Liébana Martos, Carmen, Force Sanmartín, Luis, Aranega, Raquel, Mera Fidalgo, Arantzazu, Hortos Alsina, Miquel, Merchante Gutiérrez, Nicolas, León Jiménez, Eva María, Del Pozo, José L, Serralta Buades, Josefa, Cabrera Tejada, Ginger Giorgiana, Fernández-Ruiz, Mario, Aguado, José María, Maestro de la Calle, Guillermo, Vizcarra, Pilar, Rodriguez Dominguez, Mario José, Gioia, Francesca, Del Campo, Santos, Cantón Moreno, Rafael, Martín Dávila, Pilar, Casado, José Luis, Oteo Revuelta, José Antonio, Santibáñez Sáenz, Paula, Cervera Acedo, Cristina, Ruiz Martínez, Carlos, Blanco Ramos, José Ramón, Azcona Gutiérrez, José M., García García, Concepción, Alba Fernández, Jorge, Ibarra Cucalón, Valvanera, San Franco, Mercedes, Metola Sacristán, Luis, Meijide Míguez, Héctor, Gredilla Zubiría, Íñigo, Menéndez, Justo, Villares Fernández, Paula, Montes Andújar, Lara, Navarro Batet, Álvaro, Ferrer Santolaria, Anna, Padilla Salazar, María de la Luz, Abella Vázquez, Lucy, Hayek Peraza, Marcelino, García Pardo, Antonio, Hernández Carballo, Carolina, Ruiz Fernández, Andrés Javier, Barrio López, Isabel, Martakoush, Alí, Rojas-Vieyra, Agustín, García Calvo, Sonia, Villarreal García-Lomas, Mercedes, Vizcaíno Callejón, Marta, García García, María Pilar, Lérida Urteaga, Ana, Carrasco Fons, Natalia, María Sanjuan, Beatriz, Martín González, Lydia, Sanz Zamudio, Camilo, Alejos, Belén, Moreno, Cristina, Rava, Marta, Iniesta, Carlos, Izquierdo, Rebeca, Suárez-García, Inés, Díaz, Asunción, Ruiz-Alguero, Marta, Hernando, Victoria, Frías, Jesús, Ramírez, Elena, Martín-Quirós, Alejandro, Quintana-Díaz, Manuel, Mingorance, Jesús, Arnalich, Francisco, Moreno, Francisco, Figueiras, Juan Carlos, García-Arenzana, Nicolás, Montero-Vega, María Dolores, Romero-Gómez, María Pilar, Toro-Rueda, Carlos, García-Bujalance, Silvia, Ruiz-Carrascosa, Guillermo, Cendejas-Bueno, Emilio, Falces-Romero, Iker, Lázaro-Perona, Fernando, Ruiz-Bastián, Mario, Gutiérrez-Arroyo, Almudena, Girón De Velasco-Sada, Patricia, Dahdouh, Elie, Gómez-Arroyo, Bartolomé, García-Sánchez, Consuelo, Guedez-López, Virginia, Bloise-Sánchez, Iván, Alguacil-Guillén, Marina, Liras-Hernández, Maria Gracia, Sánchez-Castellano, Miguel Angel, García-Clemente, Paloma, González-Donapetry, Patricia, San José-Villar, S, de Pablos-Gómez, Manuela, Gómez-Gil, Rosa, Corcuera-Pindado, Maria Teresa, Rico-Nieto, Alicia, Herrero, Alicia, Prieto-Arribas, Daniel, Oliver-Saez, Paloma, Mora-Corcovado, Roberto, Fernández-Calle, Pilar, Alcaide-Martín, María José, Díaz-Garzón, Jorge, Fernández-Puntero, Belén, Nuñez-Cabetas, Rocío, Crespo-Sánchez, Gema, Rodriguez-Fraga, Olaia, Mendez del Sol, Helena, Duque-Alcorta, Marta, Gomez-Rioja, Rubén, Sanz de Pedro, María, Pascual-García, Lydia, Segovia-Amaro, Marta, Iturzaeta-Sánchez, Jose Manuel, Rodriguez-Gutiérrez, Mercedes, Perez-Garcia Morillón, Amparo, Martinez Gallego, Miguel Angel, Fabre-Estremera, Blanca, Martinez-Chavez, Estefanía, Moreno-Parra, Isabel, Rodriguez-Roca, Neila, Ortiz-Sánchez, Daniel, Simon-Velasco, Manuela, Gabriela-Tomoiu, Ileana, Pizarro-Sanchez, Cristina, Montero-San Martín, Blanca, Qasem-Moreno, Ana Laila, Gómez-López, Marta, Casares Guerrero, Ismael, Buño-Soto, Antonio, Martí de Gracia, Milagros, Parra-Gordo, Luz, Diez-Tascón, Aurea, Ossaba-Vélez, Silvia, Pinilla, Inmaculada, Cuesta, Emilio, Fernández-Velilla, María, Torres, Maria Isabel, Garzón, Gonzalo, Pérez-Blanco, Verónica, Quintás-Viqueira, Almudena, San Juan, Isabel, Cantero-Escribano, José Miguel, Pérez-Romero, César, Castro-Martínez, Mercedes, Hernández-Rivas, Lucía, Pedraz, Teresa, Fernández-Bretón, Eva, García-Vaz, Claudia, Robustillo-Rodela, Ana, Torres Santos-Olmo, Rosario María, Rivera-Núñez, Angélica, Fernández-Fernández, Ignacio, Noguerol-Gutiérrez, Marina, Martínez-Virto, Ana María, González-Viñolis, Manuel, Cabrera-Gamero, Regina, Mayayo-Alvira, Rosa, Marín-Baselga, Raquel, Lo-Iacono García, Victoria, Lerín-Baratas, Macarena, Romero Gallego-Acho, Paloma, Reche-Martínez, Begoña, Tejada-Sorados, Renzo, Rico-Briñas, Mikel, Deza-Palacios, Ricardo, Fabra-Cadenas, Sara, Arroyo-Rico, Isabel, Ben-Abdellah, Lubna Dani, Labajo-Montero, Laura, Soriano-Arroyo, Rubén, López-Corcuer, Lorena, Calvin-García, Elena, Martínez-Álvarez, Susana, López-Tappero Irazábal, Laura, Pilares-Barco, Martín, González-Peña, Olga, Bejarano-Redondo, Guillermina, Iglesias-Sigüenza, Alberto, Tung-Chen, Yale, Maroun Eid, Charbel, Bravo-Lizcano, Ruth, Silvestre-Niño, Miguel, Perdomo-García, Frank, Alonso-González, Berta, Antón-Huguet, Berta, Arenas-Berenguer, Isabel, Cabré-Verdiell Surribas, Clara, Marqués-González, Francisco, Muñoz del Val, Elena, Ángeles Molina, María, Cancelliere-Fernández, Nataly, Pastor-Yvorra, Sivia, Frade-Pardo, Laura, López-Arévalo, Paloma, García, Isabel, Fernández-Capitán, Carmen, González-Garcia, Juan José, Herrero, Juan, Quesada Simón, María Angustias, Robles Marhuenda, Angel, Soto Abanedes, Clara, Noblejas Mozo, Ana María, Ramos, Juan Carlos, Jaras Hernandez, María Jesús, Martinez Robles, Elena, Moreno Fernandez, Alberto, Sanchez Purificación, Aquilino, Martin Gutiérrez, Juan Carlos, Martinez Hernández, Pedro Luis, Sancho Bueso, Teresa, Lorenzo Hernández, Alicia, Gutierrez Sancerni, Belén, Salgueiro, Giorgina, Martin Carbonero, Luz, Mostaza, Jose María, Martinez-López, María Angeles, Hontañón, Victor, Menéndez, Araceli, Alvarez Troncoso, Jorge, Castellano, Arancha, Marcelo-Calvo, Cristina, Vives-Beltrán, Ivo, Ramos Ruperto, Luis, Daroca-Bengoa, Germán, Arcos Rueda, María, Vasquez-Manau, Julia, Fernández Cidón, Pelayo, Rosario Herrero Gil, Carmen, Palmier Peláez, Esmeralda, Untoria Tabares, Yeray, Lahoz, Carlos, Estirado, Eva, Hernández, Clara, Garcia-Iglesias, Francisca, Monteoliva, Enrique, Martínez, Mónica, Vara, Marta, González Alegre, Teresa, Valencia, Maria Eulalia, Moreno, Victoria, Montes, Maria Luisa, Alcolea-Batres, Sergio, Cabanillas-Martín, Juan José, Carpio-Segura, Carlos, Casitas-Mateo, Raquel, Fernández-Bujarrabal Villoslada, Jaime, Fernández-Navarro, Isabel, Fernández-Lahera, Juan, García-Quero, Cristina, Hidalgo-Sánchez, María, Galera-Martínez, Raúl, García-Río, Francisco, Gómez-Carrera, Luis, Gómez-Mendieta, María Antonia, Mangas-Moro, Alberto, Martínez-Cerón, Elisabet, Martínez-Redondo, María, Martínez-Abad, Yolanda, Martínez-Verdasco, Antonio, Plaza-Moreno, Cristina, Quirós-Fernández, Sarai, Romera-Cano, Delia, Romero-Ribate, David, Sánchez-Sánchez, Begoña, Santiago-Recuerda, Ana, Villasante, Carlos, Zamarrón de Lucas, Ester, Arnalich-Montiel, Victoria, Mariscal-Aguilar, Pablo, Falcone, Adalgisa, Laorden-Escudero, Daniel, Prados Sánchez, María Concepción, Álvarez-Sala Walther, Rodolfo, García, Andony, Arévalo, Cristina, Gutiérrez, Carola, Yus, Santiago, Asensio, Maria José, Sánchez, Manolo, Añón, Jose Manuel, Manzanares, Jesús, García de Lorenzo, Abelardo, Perales, Eva, Civantos, Belén, Cachafeiro, Lucía, Agrifoglio, Alexander, Estébanez, Belén, Flores, Eva, Hernández, Mónica, Millán, Pablo, Rodríguez, Montserrat, Nanwani, Kapil, Arizcun, Beatriz, Pérez-Costa, Elena, Rodríguez-Álvarez, Diego, Sánchez-Martín, María, Quesada, Úrsula, Román-Hernández, Carmen, Dorao, Paloma, Álvarez-Rojas, Elena, Menéndez, Juan José, Verdú, Cristina, Gómez-Zamora, Ana, Schüffelmann, Cristina, Calderón-Llopis, Belén, Laplaza-González, María, Río-García, Miguel, Amores-Hernández, Irene, Rodríguez-Rubio, Miguel, de la Oliva, Pedro, Ruiz, Jose, Rosillo, Sandra, González, Oscar, Iniesta, Angel, Ponz, Ines, Muñoz-Ramón, José María, Hernández-Gancedo, María, Uña Orejón, Carmen R., Sanabria-Carretero, Pascual, Moreno Gómez-Limón, Isidro, Seiz-Martinez, Alverio, Guasch-Arévalo, Emilia, Martín-Carrasco, Cristina, Alvar, Elena, Serrá, Lucía, Iannuccelli, Fabricio, Latorre, Julieta, Casares, Sandra, Valbuena, Isabel, Díaz Díez Picazo, Luis, Rodríguez Roca, Cristina, Cervera, Omar, García de las Heras, Esteban, Durán, Pilar, Castro, Carmen, Manrique de Lara, Carlos, Veganzones, Javier, López-Tofiño, Araceli, Fernandez-Cerezo, Estefanía, Zurita, Sergio, López-Martinez, Mercedes, Prim, Teresa, Alvárez del Vayo, Julía, Alcaraz, Gabriela, Castro, Luis, Yagüe, Julio, Díaz-Carrasco, Sofía, González-Pizarro, Patricio, Montero, Ana, Sagra, Francisco Javier, Suárez, Alejandro, Díez-Porres, Leyre, Varela-Cerdeira, María, Alonso-Babarro, Alberto, Abellán Martínez, Francisco, Alonso-Eiras, Jorge Ignacio, Álvarez Brandt, Alejandra, Archinà, Martina, Arribas-Terradillos, Silvia, Baselga-Puente, Trinidad, Barco Núñez, Pilar, Barrera-López, Natalia Guadalupe, Barrera-López, Lorena, Bartrina-Tarrio, Andres, Bassani, Gemma, Betancort de la Torre, Paula, Blanco-Bartolomé, Irene, Blasco-Andres, Celia, Brieba-Plata, Lucía, Cadenas-Gota, Fernando, Carrera-Vázquez, Paloma, Cascajares-Sanz, Carlota, Catino, Arianna, Cavallé-Pulla, Raquel, Ceniza-Pena, Daniel, Conde-Alonso, Ylenia María, Currás-Sánchez, Laura, Daltro-Lage, Marcelo, Esteban-Romero, Ana, Fernández Vidal, María Luisa, Ferrer Ortiz, Inés, de la Fuente Regaño, Lydia, Galindo-Ballesteros, Pablo, Garcia-Bellido Ruiz, Sara, García-Mochales Fortún, Carlos, Gómez-Ballesteros, Teresa, Gómez-Domínguez, Cecilia, González-Aguado, Nelsa, González-García, Sofía, Guisández Martín, Jorge, Hernández-Liebo, Paula Alejandra, Hernando Nieto, Raquel, Llorente-Cortijo, Irene María, Marín-García, Antonio, López-Pirez, Pilar, Mejuto-Illade, Lucía, Palma, Marco, Peña-Hidalgo, Adrian, Platero-Dueñas, Lucía, Pujol-Pocull, David, Ramírez-Verdyguer, Miguel, Redondo-Gutierrez, Marta, Reinoso-Lozano, Francisco, Rodríguez-Revillas, Ana, Rodríguez Saenz de Urturi, Alejandro, Romero-Imaz, Lucía, Sánchez-Rico, Susana, Sánchez-Santiuste, Mónica, Serrano de la Fuente, Patricia, Serrano-Martín, Henar, Silva-Freire, Thamires, Soria-Alcaide, Eva, Suárez-Plaza, Andrés Enrique, Tejero-Soriano, Beatriz, Torrecillas-Mainez, Andrea, Torres-Cortés, Javier, Valentín-Pastrana Aguilar, María de las Mercedes, Villanueva-Freije, Angélica, Virgós-Varela, Marta, Yagüe-Barrado, Marta, Yustas-Benitez, Natalia, Nuñez, María Concepción, Montserrat, Jaime, Queiruga, Javier, Rodriguez-Mariblanca, Amelia, Martínez de Soto, Lucía, Urroz, Mikel, Seco, Enrique, Zubimendi, Mónica, Stuart, Stephan, Díaz, Lucía, García, Irene, García Morales, María Teresa, Martín-Vega, Alberto, Caro, Abel, Martínez-Alés, Gonzalo, Gutiérrez-Gutiérrez, Belén, del Toro, María Dolores, Borobia, Alberto M, Carcas, Antonio, Jarrín, Inmaculada, Yllescas, María, Ryan, Pablo, Pachón, Jerónimo, Carratalà, Jordi, Berenguer, Juan, Arribas, Jose Ramón, and Rodríguez-Baño, Jesús
Published: 2021
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4. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

Author: Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, López, Juan Carlos, Ramírez-Schacke, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Parras, Francisco, Catalán, Pilar, García-Leoni, María E., Pérez-Tamayo, Isabel, Puente, Luis, Cedeño, Jamil, Berenguer, Juan, Díaz Menéndez, Marta, de la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, Lago Núñez, Mª del Mar, de Miguel Buckley, Rosa, Cadiñaños Loidi, Julen, Busca Arenzana, Carmen, Mican, Alfredo, Mora Rillo, Marta, Ramos Ramos, Juan Carlos, Loeches Yagüe, Belén, Bernardino de la Serna, José Ignacio, García Rodríguez, Julio, Arribas López, José Ramón, Such Diaz, Ana, Álvaro Alonso, Elena, Izquierdo García, Elsa, Torres Macho, Juan, Cuevas Tascon, Guillermo, Troya García, Jesús, Mestre Gómez, Beatriz, Jiménez González de Buitrago, Eva, Fernández Jiménez, Inés, Tebar Martínez, Ana Josefa, Brañas Baztán, Fátima, Valencia de la Rosa, Jorge, Pérez Butragueño, Mario, Alvarado Blasco, Marta, Ryan, Pablo, Sepúlveda Berrocal, Mª Antonia, Yera Bergua, Carmen, Toledano Sierra, Pilar, Cano Llorente, Verónica, Zafar Iqubal-Mirza, Sadaf, Muñiz, Gema, Martín Pérez, Inmaculada, Mozas Moriñigo, Helena, Alguacil, Ana, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Goikoetxea Agirre, Josune, Blanco Vidal, María José, Nieto Arana, Javier, del Álamo Martínez de Lagos, Mikel, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Silvariño Fernández, Rafael, Ugalde Espiñeira, Jon, Asensi Álvarez, Víctor, Suárez Pérez, Lucia, Suárez Diaz, Silvia, Yllera Gutiérrez, Carmen, Boix, Vicente, Díez Martínez, Marcos, Carreres Candela, Melissa, Gómez-Ayerbe, Cristina, Sánchez-Lora, Javier, Velasco Garrido, José Luis, López-Jódar, María, Santos González, Jesús, Ruiz Aragón, Jesús, Virto Peña, Ianire, Alende Castro, Vanessa, Brea Aparicio, Ruth, Vega Molpeceres, Sonia, Pons Viñas, Estel, del Río Pérez, Oscar, Valero Rovira, Silvia, Villar-García, Judit, Gómez-Junyent, Joan, Knobel, Hernando, Cánepa, María Cecilia, Castañeda Espinosa, Silvia, Sorli Redò, Luisa, Güerri-Fernández, Roberto, Milagro Montero, María, Horcajada, Juan Pablo, García Vázquez, Elisa, Moral Escudero, Encarnación, Hernández Torres, Alicia, García Almodóvar, Esther, Sáez Barberá, Carmen, Karroud, Zineb, Hernández Quero, José, Vinuesa García, David, García Fogeda, José Luis, Peregrina, José Antonio, Novella Mena, María, Hernández Gutiérrez, Cristina, Sanz Moreno, José, Pérez Tanoira, Ramón, Sierra Rodríguez, Rodrigo, Alonso Menchén, David, Gutiérrez García, Aida, Arranz Caso, Alberto, Cuadros González, Juan, Álvarez de Mon Soto, Melchor, Díaz de Brito Fernández, Vicente Ferrer, Sanmarti Vilamala, Montserrat, Gabarrell Pascuet, Aina, Molina Morant, Daniel, España Cueto, Sergio, Cámara Fernández, Jonathan, Sabater Gil, Albert, Muñoz López, Laura, Sáez Escolano, Paula, Bejarano Tello, Esperanza, Sempere Alcocer, Marco Antonio, Álvarez Martin, Salvador, De los Santos Gil, Ignacio, García-Fraile, Lucio, Sampedro Núñez, Miguel, Barrios Blandino, Ana, Rodríguez Franco, Carlos, Useros Brañas, Daniel, Villa Martí, Almudena, Oliver Ortega, Javier, Costanza Espiño Álvarez, Alexia, Sanz Sanz, Jesús, Rexach Fumaña, María, Abascal Cambras, Ivette, Pérez Jaén, Ana del Cielo, Sala Jofre, Clara, Casas Rodríguez, Susana, Tortajada Alamilla, Cecilia, Oltra, Carmina, Masiá Canuto, Mar, Gutiérrez Rodero, Félix, Ferrer Ribera, Ana, Bea Serrano, Carlos, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, Fiorante, Silvana, Pérez Pinto, Sergio, Hernández Machín, Pilar, Alastrué Violeta, Alba, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Gozalo, Mónica, Mora Gómez, Francisco, Milagro Beamonte, Ana, Latorre-Millán, Miriam, Rezusta López, Antonio, Martínez Sapiña, Ana, Meije, Yolanda, Duarte Borges, Alejandra, Pareja Coca, Julia, Clemente Presas, Mercedes, Losa García, Juan Emilio, Vegas Serrano, Ana, Pérez-Rodríguez, M. Teresa, Pérez González, Alexandre, Belhassen-García, Moncef, Rodríguez-Alonso, Beatriz, López-Bernus, Amparo, Carbonell, Cristina, Torres Perea, Rafael, Cantón de Seoane, Juan, Alonso, Blanca, Kamal, Sara Lidia, Cajuela, Lucia, Roa, David, Cervero, Miguel, Oreja, Alberto, Avilés, Juan Pablo, Martín, Lidia, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Abadia Otero, Jessica, Salillas Hernando, Juan, Torres Sánchez del Arco, Robert, Torralba González de Suso, Miguel, Serrano Martínez, Alberto, Gilaberte Reyzábal, Sergio, Pacheco Martínez-Atienza, Marina, Liébana Gómez, Mónica, Fernández Rodríguez, Sara, Varela Plaza, Álvaro, Calvo Sánchez, Henar, Martínez Martín, Patricia, González- Ruano, Patricia, Malmierca Corral, Eduardo, Rábago Lorite, Isabel, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Sirisi, Merce, Rojas, Richard, Díaz de Tuesta del Arco, José Luis, Figueroa Cerón, Ruth, González Sarria, Ander, Alemán Valls, Remedios, Alonso Socas, María del Mar, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Riera Jaume, Melchor, Vilchez, Helem Haydee, Albertí, Francesc, Cañabate, Ana Isabel, Moreno Cuerda, Víctor J., Álvarez Kaelis, Silvia, Álvarez Zapatero, Beatriz, García García, Alejandro, Isaba Ares, Elena, Morcate Fernández, Covadonga, Pérez Rodríguez, Andrea, Ramos Merino, Lucía, Castelo Corral, Laura, Rodríguez Mahía, María, González Bardanca, Mónica, Sánchez Vidal, Efrén, Míguez Rey, Enrique, De la Torre Lima, Javier, García de Lomas Guerrero, José Mª, Morte, Elena, Loscos, Silvia, Camón, Ana, Gómez García, Lucía, Boix Palop, Lucia, Dietl Gómez-Luengo, Beatriz, Pedrola Gorrea, Iris, Blasco Claramunt, Amparo, López Mestanza, Cristina, Fraile Villarejo, Esther, Tosco Núñez, Tomás, Aroca Ferri, María, Algado Rabasa, José Tomas, Garijo Saiz, Ana María, Amador Prous, Concepción, Baño, Jesús Rodriguez, Retamar, Pilar, Valiente, Adoración, López-Cortés, Luis E., Sojo, Jesús, Gutiérrez-Gutiérrez, Belén, Bravo-Ferrer, José, Salamanca, Elena, Palacios, Zaira R., Pérez-Palacios, Patricia, Peral, Enrique, Pérez de León, José Antonio, Sánchez-Gómez, Jesús, Marín-Barrera, Lucía, García-Jiménez, Domingo, Carratalà, Jordi, Abelenda-Alonso, Gabriela, Ardanuy, Carmen, Bergas, Alba, Cuervo, Guillermo, Domínguez, María Ángeles, Fernández-Huerta, Miguel, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Pérez-Recio, Sandra, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Trullen, Núria, Salavert Lletí, Miguel, Castro Hernández, Iván, Hernández Belmonte, Adriana, Martínez Goñi, Raquel, Navarro Vilasaró, Marta, Calzado Isbert, Sonia, Cervantes García, Manuel, Gomila Grange, Aina, Gasch Blasi, Oriol, Machado Sicilia, María Luisa, Van den Eynde Otero, Eva, Falgueras López, Luis, Navarro Sáez, María del Carmen, Martínez, Esteban, Marcos, Mª Ángeles, Mosquera, Mar, Blanco, José Luis, Laguno, Montserrat, Rojas, Jhon, González-Cordón, Ana, Inciarte, Alexy, Torres, Berta, De la Mora, Lorena, Soriano, Alex, Martínez Macias, Olalla, Pérez Doñate, Virginia, Cabello Úbeda, Alfonso, Carrasco Antón, Nerea, Álvarez Álvarez, Beatriz, Petkova Saiz, Elizabet, Górgolas Hernández-Mora, Miguel, Prieto Pérez, Laura, Carrillo Acosta, Irene, Heili Frades, Sara, Villar Álvarez, Felipe, Fernández Roblas, Ricardo, Milicua Muñoz, José María, Fernández Espinilla, Virginia, Dueñas Gutiérrez, Carlos Jesús, Hernán García, Cristina, González-Romo, Fernando, Merino Amador, Paloma, Rueda López, Alba, Martínez Jordán, Jorge, Medrano Pardo, Sara, Díaz de la Torre, Irene, Posada Franco, Yolanda, Delgado-Iribarren, Alberto, López-Contreras González, Joaquín, Pascual Alonso, Pablo, Pomar Solchaga, Virginia, Rabella García, Nuria, Benito Hernández, Natividad, Domingo Pedrol, Pere, Bonfill Cosp, Xavier, Padrós Selma, Rafael, Puig Campmany, Mireia, Mancebo Cortés, Jordi, Gurguí Ferrer, Mercè, Íñigo Pestaña, Melania, Pérez García, Alejandra, Sorní Moreno, Patricia, Izko Gartzia, Nora, Membrillo de Novales, Francisco Javier, Simón Sacristán, María, Zamora Cintas, Maribel, Martínez Martínez, Yolanda, Fernández-González, Pablo, Alcántara Nicolás, Francisco, Aguirre Vila-Cora, Alejandro, López Tizón, Elena, Ramírez-Olivencia, Germán, Estébanez Muñoz, Miriam, Sáez de Adana Arróniz, Ester, Portu Zapirain, Joseba, Gainzarain Arana, Juan Carlos, Ortiz de Zárate Ibarra, Zuriñe, Moran Rodríguez, Miguel Ángel, Canut Blasco, Andrés, Hernáez Crespo, Silvia, Balerdi Sarasola, Leire, Morales García, Cristina, Corral Saracho, Miguel, Valcarce González, Zeltia, Arenal Andrés, Noelia, Rodríguez Tarazona, Raquel Elisa, Iglesias Llorente, Laura, Loureiro Rodríguez, Beatriz, Sánchez Montalvá, Adrián, Espinosa Pereiro, Juan, Almirante, Benito, Miarons, Marta, Sellarés, Júlia, Larrosa, María, García, Sonia, Marzo, Blanca, Villamarín, Miguel, Fernández, Nuria, Pérez-Jorge Peremarch, Conchita, Resino Foz, Elena, Espigares Correa, Andrea, Álvarez de Espejo Montiel, Teresa, Navas Clemente, Iván, Quijano Contreras, María Isabel, Nieto Fernández del Campo, Luis Alberto, Jiménez Álvarez, Guillermo, Guillamón Sánchez, Mercedes, García García, Josefina, Muñoz Hornero, Constanza, Mariño Callejo, Ana, Valcarce Pardeiro, Nieves, Smithson Amat, Alex, Chico Chumillas, Cristina, Sánchez Serrano, Adriana, García Villalba, Eva Pilar, Jiménez Martínez, Isabel, Estrada Fernández, Guillermo, Lorén Vargas, María, Parra Arribas, Nuria, Martínez Cilleros, Carmen, Villasante de la Puente, Aránzazu, García Delange, Teresa, Ruiz Rodríguez, María José, Robledo del Prado, Marta, Abad Almendro, Juan Carlos, Muñoz del Rey, José Román, Jiménez Álvaro, Montaña, Coy Coy, Javier, Poquet Catala, Inmaculada, Santos Peña, Marta, Naranjo Velasco, Virginia, Manso Gómez, Tamara, Quilez Ágreda, Delia, Barbeito Castiñeiras, Gema, Domínguez Santalla, María Jesús, Mao Martín, Laura, Alonso Navarro, Rodrigo, Ampuero Martinich, Jose David, Barrós González, Raquel, Galindo Martín, María Aránzazu, Herrera Pacheco, Lourdes, Martínez Avilés, Rocío, Rodrigo González, Sara, Rodríguez Leal, Cristóbal Manuel, Romay Lema, Eva María, Suárez Gil, Roi, Ibarguren Pinilla, Maialen, Marimón Ortiz de Zárate, José María, Vidaur Tello, Loreto, Kortajarena Urkola, Xabier, García Gómez, Miriam, Aranguren Arostegui, Asier, Álvarez de Castro, Maria, Martínez Mateu, Cintia María, Rodríguez Gómez, Francisco, Muñoz Beamud, Francisco, Chamarro Martí, Elena, Cardona Rivera, Merce, Zakariya-Yousef Breval, Ismail, Rico Rodríguez, Marta, Llenas García, Jara, Sánchez Arenas, Mª Carmen, Fernández Cruz, Ana, Calderón Parra, Jorge, López Dosil, Marcos, Ramos Martínez, Antonio, Múñez Rubio, Elena, Callejas Díaz, Alejandro, Vázquez Comendador, José Manuel, Diego Yagüe, Itziar, Expósito Palomo, Esther, Anel Pedroche, Jorge, Álvarez Franco, Raquel, Fernández de Orueta, Lucía, Vates Gómez, Roberto, Cardona Arias, Andrés Felipe, Marguenda Contreras, Pablo, Gaspar Alonso-Vega, Gabriel, Aranda Rife, Elena María, Martínez Cifre, Blanca, Roger Zapata, Daniel, Martín Rubio, Irene, Barbosa Ventura, André, Piñero, Iván, Bahamonde Carrasco, Alberto, Runza Buznego, Paula, Talavera García, Eva, Lamata Subero, Marta, Urrutia Losada, Ainhoa, Arteche Eguizabal, Lorea, Delgado Sánchez, Elisabet, Molina Peinado, Virginia, Caro Bragado, Sarah, Domínguez de Pablos, Gema, Roldán Fontana, Carolina, Herrero Rodríguez, Carmen, Force Sanmartín, Luis, Aranega, Raquel, Mera Fidalgo, Arantzazu, Toda Savall, María Roca, Merchante Gutiérrez, Nicolas, León Jiménez, Eva María, Del Pozo, José Luís, Serralta Buades, Josefa, Cabrera Tejada, Ginger Giorgiana, Fernández-Ruiz, Mario, Aguado, José María, Maestro de la Calle, Guillermo, Cisneros, José Miguel, Pachón, Jerónimo, Aguilar-Guisado, Manuela, Aldabó, Teresa, Avilés, María Dolores, Bueno, Claudio, Cordero-Matía, Elisa, Escoresca, Ana, Gálvez-Benítez, Lydia, Infante, Carmen, Martín, Guillermo, Praena, Julia, Roca, Cristina, Salamanca, Celia, Suárez-Benjumea, Alejandro, Vizcarra, Pilar, Quereda, Carmen, Rodriguez Dominguez, Mario José, Gioia, Francesca, Norman, Francesca, Del Campo, Santos, Cantón Moreno, Rafael, Oteo Revuelta José, Antonio, Santibáñez Sáenz, Paula, Cervera Acedo, Cristina, Ruiz Martínez, Carlos, Blanco Ramos, José R., Azcona Gutiérrez, José M., García García, Concepción, Alba Fernández, Jorge, Ibarra Cucalón, Valvanera, San Franco, Mercedes, Metola Sacristán, Luis, Meijide Míguez, Héctor, Paulos Viñas, Silvia, Menéndez, Justo, Villares Fernández, Paula, Montes Andújar, Lara, Navarro Batet, Álvaro, Ferrer Santolaria, Anna, Padilla Salazar, María de la Luz, Abella Vázquez, Lucy, Hayek Peraza, Marcelino, García Pardo, Antonio, Hernández Carballo, Carolina, Ruiz Fernández, Andrés Javier, Barrio López, Isabel, Martakoush, Alí, Rojas-Vieyra, Agustín, García Calvo, Sonia, Villarreal García-Lomas, Mercedes, Vizcaíno Callejón, Marta, García García, María Pilar, Lérida Urteaga, Ana, Carrasco Fons, Natalia, María Sanjuan, Beatriz, Martín González, Lydia, Sanz Zamudio, Camilo, Jarrín, Inmaculada, Alejos, Belén, Moreno, Cristina, Rava, Marta, Iniesta, Carlos, Izquierdo, Rebeca, Suárez-García, Inés, Díaz, Asunción, Ruiz-Alguero, Marta, Hernando, Victoria, Rodríguez-Baño, Jesús, Yllescas, María, and Arriba, José Ramón
Published: 2020
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5. Does my patient really need this at admission? Seven opportunities for improving value in patient care during their hospitalization

Author: Corral-Gudino, Luis, Rivas-Lamazares, Alicia, González-Fernández, Ana, Rodríguez-María, Miriam, Aguilera-Sanz, Carmen, Tierra-Rodríguez, Ana, Runza-Buznego, Paula, Hernández-Martín, Ester, Ortega-Gil, Martín, and Bahamonde-Carrasco, Alberto
Published: 2019
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6. Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study

Author: Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Núñez-Pereira, Susana, Benavent Palomares, Eva, Ulldemolins, Marta, Sobrino-Díaz, Beatriz, Iribarren, José A., Escudero-Sánchez, Rosa, Toro, María Dolores del, Nodar, Andrés, Sorlí, Luisa, Bahamonde-Carrasco, Alberto, Vilchez, Helem H., Gasch, Oriol, Muñez, Elena, Rodriguez-Montserrat, David, García-País, María José, Haddad, Sleiman, Sellarès-Nadal, Julia, Murillo, Óscar, Rodríguez-Pardo, Dolors, Geio-Seimc Group, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Núñez-Pereira, Susana, Benavent Palomares, Eva, Ulldemolins, Marta, Sobrino-Díaz, Beatriz, Iribarren, José A., Escudero-Sánchez, Rosa, Toro, María Dolores del, Nodar, Andrés, Sorlí, Luisa, Bahamonde-Carrasco, Alberto, Vilchez, Helem H., Gasch, Oriol, Muñez, Elena, Rodriguez-Montserrat, David, García-País, María José, Haddad, Sleiman, Sellarès-Nadal, Julia, Murillo, Óscar, Rodríguez-Pardo, Dolors, and Geio-Seimc Group
Abstract: Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0.025), although 55.6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29.6% vs. 12.8%; p = 0.014) and received shorter antibiotic regimens (p = 0.014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin.
Published: 2023

7. Conventional Hospitalization versus Sequential Outpatient Parenteral Antibiotic Therapy for Staphylococcus aureus Bacteremia: Post-Hoc Analysis of a Multicenter Observational Cohort

Author: Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Castillo-Fernández, Nerea, Pérez-Crespo, Pedro María Martínez, Salamanca, Elena, Herrera-Hidalgo, Laura, Alarcón González, Arístides de, Navarro-Amuedo, María Dolores, Marrodán, Teresa, Pérez-Rodríguez, María Teresa, Sevilla Blanco, Juan, Jover-Sáenz, Alfredo, Fernández Suárez, Jonathan, Armiñanzas Castillo, Carlos, Reguera-Iglesias, J. M., Natera Kindelán, Clara, Boix-Palop, Lucía, León Jiménez, Eva, Galán-Sánchez, Fátima, Arco-Jiménez, Alfonso del, Bahamonde-Carrasco, Alberto, Vinuesa García, David, Smithson Amat, Alejandro, Cuquet Pedragosa, Jordi, Reche Molina, Isabel María, Pérez-Camacho, Inés, Merino de Lucas, Esperanza, Gutiérrez-Gutiérrez, Belén, Rodríguez-Baño, Jesús, López-Cortés, Luis Eduardo, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Castillo-Fernández, Nerea, Pérez-Crespo, Pedro María Martínez, Salamanca, Elena, Herrera-Hidalgo, Laura, Alarcón González, Arístides de, Navarro-Amuedo, María Dolores, Marrodán, Teresa, Pérez-Rodríguez, María Teresa, Sevilla Blanco, Juan, Jover-Sáenz, Alfredo, Fernández Suárez, Jonathan, Armiñanzas Castillo, Carlos, Reguera-Iglesias, J. M., Natera Kindelán, Clara, Boix-Palop, Lucía, León Jiménez, Eva, Galán-Sánchez, Fátima, Arco-Jiménez, Alfonso del, Bahamonde-Carrasco, Alberto, Vinuesa García, David, Smithson Amat, Alejandro, Cuquet Pedragosa, Jordi, Reche Molina, Isabel María, Pérez-Camacho, Inés, Merino de Lucas, Esperanza, Gutiérrez-Gutiérrez, Belén, Rodríguez-Baño, Jesús, and López-Cortés, Luis Eduardo
Abstract: It is not known whether sequential outpatient parenteral antimicrobial (OPAT) is as safe and effective as conventional hospitalization in patients with S. aureus bacteremia (SAB). A post-hoc analysis of the comparative effectiveness of conventional hospitalization versus sequential OPAT was performed in two prospective Spanish cohorts of patients with S. aureus bacteremia. The PROBAC cohort is a national, multicenter, prospective observational cohort of patients diagnosed in 22 Spanish hospitals between October 2016 and March 2017. The DOMUS OPAT cohort is a prospective observational cohort including patients from two university hospitals in Seville, Spain from 2012 to 2021. Multivariate regression was performed, including a propensity score (PS) for receiving OPAT, stratified analysis according to PS quartiles, and matched pair analyses based on PS. Four hundred and thirteen patients were included in the analysis: 150 in sequential OPAT and 263 in the full hospitalization therapy group. In multivariate analysis, including PS and center effect as covariates, 60-day treatment failure was lower in the OPAT group than in the full hospitalization group (p < 0.001; OR 0.275, 95%CI 0.129−0.584). In the PS-based matched analyses, sequential treatment under OPAT was not associated with higher 60-day treatment failure (p = 0.253; adjusted OR 0.660; % CI 0.324−1.345). OPAT is a safe and effective alternative to conventional in-patient therapy for completion of treatment in well-selected patients with SAB, mainly those associated with a low-risk source and without end-stage kidney disease.
Published: 2023

8. Conventional Hospitalization versus Sequential Outpatient Parenteral Antibiotic Therapy for Staphylococcus aureus Bacteremia: Post-Hoc Analysis of a Multicenter Observational Cohort

Author: Castillo-Fernández, Nerea, primary, Pérez-Crespo, Pedro María Martínez, additional, Salamanca-Rivera, Elena, additional, Herrera-Hidalgo, Laura, additional, de Alarcón, Arístides, additional, Navarro-Amuedo, María Dolores, additional, Marrodán Ciordia, Teresa, additional, Pérez-Rodríguez, María Teresa, additional, Sevilla-Blanco, Juan, additional, Jover-Saenz, Alfredo, additional, Fernández-Suárez, Jonathan, additional, Armiñanzas-Castillo, Carlos, additional, Reguera-Iglesias, José María, additional, Natera Kindelán, Clara, additional, Boix-Palop, Lucía, additional, León Jiménez, Eva, additional, Galán-Sánchez, Fátima, additional, del Arco Jiménez, Alfonso, additional, Bahamonde-Carrasco, Alberto, additional, Vinuesa García, David, additional, Smithson Amat, Alejandro, additional, Cuquet Pedragosa, Jordi, additional, Reche Molina, Isabel María, additional, Pérez Camacho, Inés, additional, Merino de Lucas, Esperanza, additional, Gutiérrez-Gutiérrez, Belén, additional, Rodríguez Baño, Jesús, additional, and López Cortés, Luis Eduardo, additional
Published: 2023
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9. Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project

Author: Mussa, Marco, Martínez Pérez-Crespo, Pedro María, Lopez-Cortes, Luis Eduardo, Retamar-Gentil, Pilar, Sousa-Dominguez, Adrián, Goikoetxea-Aguirre, Ane Josune, Reguera-Iglesias, José María, León Jiménez, Eva, Fernández-Natal, Isabel, Armiñanzas-Castillo, Carlos, Boix-Palop, Lucía, Cuquet-Pedragosa, Jordi, Morán Rodríguez, Miguel Ángel, Fernandez-Suarez, Jonathan, Del Arco-Jiménez, Alfonso, Jóver-Saenz, Alfredo, Bahamonde-Carrasco, Alberto, Galan-Sanchez, Fátima, Sánchez-Calvo, Juan Manuel, Smithson-Amat, Alejandro, Vinuesa-García, David, Sánchez-Porto, Antonio, López-Hernández, Inmaculada, Rodríguez-Baño, Jesús, PROBAC REIPI/GEIH-SEIMC/SAEI group, [Mussa M] Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Milan, Italy. UGC Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Sevilla, Spain. Departamento de Medicina, Universidad de Sevilla/IBiS/CSIC, Sevilla, Spain. [Martínez Pérez-Crespo PM] Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Sevilla, Spain. Hospital Universitario de Valme, Sevilla, Spain. [Lopez-Cortes LE] UGC Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Sevilla, Spain. Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Sevilla, Spain. [Retamar-Gentil P] UGC Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Sevilla, Spain. Departamento de Medicina, Universidad de Sevilla/IBiS/CSIC, Sevilla, Spain. Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Sevilla, Spain. [Sousa-Dominguez A] Hospital Universitario de Vigo, Vigo, Spain. [Goikoetxea-Aguirre AJ] Hospital de Cruces, Bilbao, Spain. [Cuquet-Pedragosa J] Hospital General Granollers, Granollers, Spain, Hospital General de Granollers, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Red Española de Investigación en Patología Infecciosa, and Universidad de Cantabria
Subjects: Microbiology (medical), Enterococs, Physiology, Cholangitis, Enterococcus faecium, bloodstream infection, Bacteremia, Bloodstream infection, Cholangiocarcinoma, Cohort Studies, Bacterièmia, Risk Factors, Genetics, Enterococcus faecalis, Humans, Renal Insufficiency, Chronic, Biliary Tract, Gram-Positive Bacterial Infections, Aged, General Immunology and Microbiology, Ecology, Enterococcus spp, Biliary tract infection, Cell Biology, Anti-Bacterial Agents, Infectious Diseases, Bacteria::Firmicutes::Lactobacillales::Enterococcaceae::Enterococcus [ORGANISMS], Carbapenems, biliary tract infection, Conductes biliars - Infeccions, Bacteria::Firmicutes::Lactobacillales::Enterococcaceae::Enterococcus [ORGANISMOS], Enterococcus
Abstract: Biliary-tract bloodstream infections (BT-BSI) caused by Enterococcus faecalis and E. faecium are associated with inappropriate empirical treatment and worse outcomes compared to other etiologies. The objective of this study was to investigate the risk factors for enterococcal BT-BSI. Patients with BT-BSI from the PROBAC cohort, including consecutive patients with BSI in 26 Spanish hospitals between October 2016 and March 2017, were selected; episodes caused by E. faecalis or E. faecium and other causes were compared. Independent predictors for enterococci were identified by logistic regression, and a predictive score was developed. Eight hundred fifty episodes of BT-BSI were included; 73 (8.5%) were due to target Enterococcus spp. (48 [66%] were E. faecium and 25 [34%] E. faecalis). By multivariate analysis, the variables independently associated with Enterococcus spp. were (OR; 95% confidence interval): cholangiocarcinoma (4.48;1.32 to 15.25), hospital acquisition (3.58;2.11 to 6.07), use of carbapenems in the previous month (3.35;1.45 to 7.78), biliary prosthesis (2.19;1.24 to 3.90), and moderate or severe chronic kidney disease (1.55;1.07 to 2.26). The AUC of the model was 0.74 [95% CI0.67 to 0.80]. A score was developed, with 7, 6, 5, 4, and 2 points for these variables, respectively, with a negative predictive value of 95% for a score ≤ 6. A model, including cholangiocarcinoma, biliary prosthesis, hospital acquisition, previous carbapenems, and chronic kidney disease showed moderate prediction ability for enterococcal BT-BSI. Although the score will need to be validated, this information may be useful for deciding empirical therapy in biliary tract infections when bacteremia is suspected. IMPORTANCE Biliary tract infections are frequent, and a significant cause of morbidity and mortality. Bacteremia is common in these infections, particularly in the elderly and patients with cancer. Inappropriate empirical treatment has been associated with increased risk of mortality in bacteremic cholangitis, and the probability of receiving inactive empirical treatment is higher in episodes caused by enterococci. This is because many of the antimicrobial agents recommended in guidelines for biliary tract infections lack activity against these organisms. To the best of our knowledge, this is the first study analyzing the predictive factors for enterococcal BT-BSI and deriving a predictive score., This work was financed by Plan Nacional de I+D+i 2013‐2016, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades, through grants PI16/01432 and Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0007; and RD16/0016/0012]; co‐financed by European Development Regional Fund “A Way to Achieve Europe,” Operative program Intelligent Growth 2014–2020.
Published: 2022

10. Pseudomonas aeruginosa Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development—Results from the PRO-BAC Cohort

Author: Martínez Pérez-Crespo, Pedro María, Rojas, Álvaro, Lanz-García, Joaquín Felipe, Retamar-Gentil, Pilar, Reguera-Iglesias, José María, Lima-Rodríguez, Olalla, Del Arco Jiménez, Alfonso, Fernández Suárez, Jonathan, Jover-Saenz, Alfredo, Goikoetxea Aguirre, Josune, León Jiménez, Eva, Cantón-Bulnes, María Luisa, Ortega Lafont, Pilar, Armiñanzas Castillo, Carlos, Sevilla Blanco, Juan, Cuquet Pedragosa, Jordi, Boix-Palop, Lucía, Becerril Carral, Berta, Bahamonde-Carrasco, Alberto, Marrodan Ciordia, Teresa, Natera Kindelán, Clara, Reche Molina, Isabel María, Herrero Rodríguez, Carmen, Pérez Camacho, Inés, Vinuesa García, David, Galán-Sánchez, Fátima, Smithson Amat, Alejandro, Merino de Lucas, Esperanza, Sánchez-Porto, Antonio, Guzmán García, Marcos, López-Hernández, Inmaculada, Rodríguez-Baño, Jesús, López-Cortés, Luis Eduardo, On Behalf Of The Probac Reipi/Geih-Seimc/Saei Group, [Martínez Pérez-Crespo PM] Infectious Diseases and Microbiology Unit, Hospital Universitario Virgen Macarena and Department of Medicine, University of Sevilla/Biomedicines Institute of Sevilla, Sevilla, Spain. Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario Nuestra Señora de Valme, Sevilla, Spain. [Rojas Á] Departamento de Enfermedades Infecciosas del Adulto, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. [Lanz-García JF, Retamar-Gentil P] Infectious Diseases and Microbiology Unit, Hospital Universitario Virgen Macarena and Department of Medicine, University of Sevilla/Biomedicines Institute of Sevilla, Sevilla, Spain. [Reguera-Iglesias JM] Servicio de Enfermedades Infecciosas, Hospital Regional Universitario de Málaga, IBIMA Málaga, Málaga, Spain. [Lima-Rodríguez O] Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Álvaro Cunqueiro, Vigo, Spain. [Cuquet Pedragosa J] Departamento de Medicina Interna, Hospital General de Granollers, Granollers, Spain, Hospital General de Granollers, and Universidad de Cantabria
Subjects: Microbiology (medical), bacteraemia, Epidemiology, Sang - Infeccions, bloodstream infection, community-onset, Bloodstream infection, Bacteria::bacterias gramnegativas::bacterias aerobias gramnegativas::bacilos y cocos aerobios gramnegativos::Pseudomonadaceae::Pseudomonas::Pseudomonas aeruginosa [ORGANISMOS], bacterial infections and mycoses, Biochemistry, Microbiology, Pseudomonas aeruginosa, epidemiology, Pseudomones, Infectious Diseases, Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Pseudomonadaceae::Pseudomonas::Pseudomonas aeruginosa [ORGANISMS], Community-onset, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Epidemiologia, human activities
Abstract: Community-onset bloodstream infections (CO-BSI) caused by gram-negative bacilli are common and associated with significant mortality; those caused by Pseudomonas aeruginosa are associated with worse prognosis and higher rates of inadequateempirical antibiotic treatment. The aims of this study were to describe the characteristics of patients with CO-BSI caused by P. aeruginosa, to identify predictors, and to develop a predictive score for P. aeruginosa CO-BSI. Materials/methods: PROBAC is a prospective cohort including patients >14 years with BSI from 26 Spanish hospitals between October 2016 and May 2017. Patients with monomicrobial P. aeruginosa CO-BSI and monomicrobial Enterobacterales CO-BSI were included. Variables of interest were collected. Independent predictors of Pseudomonas aeruginosa CO-BSI were identified by logistic regression and a prediction score was developed. Results: A total of 78patients with P. aeruginosa CO-BSI and 2572 with Enterobacterales CO-BSI were included. Patients with P. aeruginosa had a median age of 70 years (IQR 60-79), 68.8% were male, median Charlson score was 5 (IQR 3-7), and 30-daymortality was 18.5%. Multivariate analysis identified the following predictors of CO-BSI-PA [adjusted OR (95% CI)]: male gender [1.89 (1.14-3.12)], haematological malignancy [2.45 (1.20-4.99)], obstructive uropathy [2.86 (1.13-3.02)], source of infection other than urinary tract, biliary tract or intra-abdominal [6.69 (4.10-10.92)] and healthcare-associated BSI [1.85 (1.13-3.02)]. Anindex predictive of CO-BSI-PA was developed; scores ? 3.5 showed a negative predictive value of 89% and an area under the receiver operator curve (ROC) of 0.66. Conclusions: We did not find a good predictive score of P. aeruginosa CO-BSI due to its relatively low incidence in the overall population. Our model includes variables that are easy to collect in real clinical practice and could be useful to detect patients with very low risk of P. aeruginosa CO-BSI. This work was financed by grants from the Plan Nacional de I + D+i 2013–2016-Instituto de Salud Carlos III (Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades) [PI16/01432]; and Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0008]; co-financed by the European Development Regional Fund “A way to achieve Europe”, Operative program Intelligent Growth 2014–2020.
Published: 2022

11. Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project

Author: Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Red Española de Investigación en Patología Infecciosa, Mussa, Marco, Martínez Pérez-Crespo, Pedro María, López-Cortés, Luis Eduardo, Retamar Gentil, Pilar, Sousa, Adrián, Goikoetxea-Aguirre, Josune, Reguera-Iglesias, J. M., León Jiménez, Eva, Fernández-Natal, Isabel, Armiñanzas Castillo, Carlos, Boix-Palop, Lucía, Cuquet Pedragosa, Jordi, Morán Rodríguez, Miguel Ángel, Fernández Suárez, Jonathan, Arco-Jiménez, Alfonso del, Jover-Sáenz, Alfredo, Bahamonde-Carrasco, Alberto, Galán-Sánchez, Fátima, Sánchez Calvo, J. M., Smithson Amat, Alejandro, Vinuesa García, David, Sánchez-Porto, Antonio, López-Hernández, Inmaculada, Rodríguez-Baño, Jesús, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Red Española de Investigación en Patología Infecciosa, Mussa, Marco, Martínez Pérez-Crespo, Pedro María, López-Cortés, Luis Eduardo, Retamar Gentil, Pilar, Sousa, Adrián, Goikoetxea-Aguirre, Josune, Reguera-Iglesias, J. M., León Jiménez, Eva, Fernández-Natal, Isabel, Armiñanzas Castillo, Carlos, Boix-Palop, Lucía, Cuquet Pedragosa, Jordi, Morán Rodríguez, Miguel Ángel, Fernández Suárez, Jonathan, Arco-Jiménez, Alfonso del, Jover-Sáenz, Alfredo, Bahamonde-Carrasco, Alberto, Galán-Sánchez, Fátima, Sánchez Calvo, J. M., Smithson Amat, Alejandro, Vinuesa García, David, Sánchez-Porto, Antonio, López-Hernández, Inmaculada, and Rodríguez-Baño, Jesús
Abstract: Biliary-tract bloodstream infections (BT-BSI) caused by Enterococcus faecalis and E. faecium are associated with inappropriate empirical treatment and worse outcomes compared to other etiologies. The objective of this study was to investigate the risk factors for enterococcal BT-BSI. Patients with BT-BSI from the PROBAC cohort, including consecutive patients with BSI in 26 Spanish hospitals between October 2016 and March 2017, were selected; episodes caused by E. faecalis or E. faecium and other causes were compared. Independent predictors for enterococci were identified by logistic regression, and a predictive score was developed. Eight hundred fifty episodes of BT-BSI were included; 73 (8.5%) were due to target Enterococcus spp. (48 [66%] were E. faecium and 25 [34%] E. faecalis). By multivariate analysis, the variables independently associated with Enterococcus spp. were (OR; 95% confidence interval): cholangiocarcinoma (4.48;1.32 to 15.25), hospital acquisition (3.58;2.11 to 6.07), use of carbapenems in the previous month (3.35;1.45 to 7.78), biliary prosthesis (2.19;1.24 to 3.90), and moderate or severe chronic kidney disease (1.55;1.07 to 2.26). The AUC of the model was 0.74 [95% CI0.67 to 0.80]. A score was developed, with 7, 6, 5, 4, and 2 points for these variables, respectively, with a negative predictive value of 95% for a score ≤ 6. A model, including cholangiocarcinoma, biliary prosthesis, hospital acquisition, previous carbapenems, and chronic kidney disease showed moderate prediction ability for enterococcal BT-BSI. Although the score will need to be validated, this information may be useful for deciding empirical therapy in biliary tract infections when bacteremia is suspected. IMPORTANCE Biliary tract infections are frequent, and a significant cause of morbidity and mortality. Bacteremia is common in these infections, particularly in the elderly and patients with cancer. Inappropriate empirical treatment has been associated with increased risk of mo
Published: 2022

12. Mediterranean spotted fever with lymphangitis occurring from a tick bite lesion. A case in Spain

Author: Barja López, Juan Manuel, Bahamonde Carrasco, Alberto, Alija Senra, Antonio, Manjón Haces, Jose Antonio, and Soto del Moral, Francisco
Published: 2015
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13. Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

Author: Pérez-Crespo, Pedro María Martínez, primary, Lanz-García, Joaquín Felipe, additional, Bravo-Ferrer, José, additional, Cantón-Bulnes, María Luisa, additional, Sousa Domínguez, Adrian, additional, Goikoetxea Aguirre, Josune, additional, Reguera-Iglesias, José María, additional, León Jiménez, Eva, additional, Armiñanzas Castillo, Carlos, additional, Mantecón Vallejo, María Ángeles, additional, Marrodan Ciordia, Teresa, additional, Fernández Suárez, Jonathan, additional, Boix-Palop, Lucía, additional, Cuquet Pedragosa, Jordi, additional, Jover Saenz, Alfredo, additional, Sevilla Blanco, Juan, additional, Galán-Sánchez, Fátima, additional, Natera Kindelán, Clara, additional, del Arco Jiménez, Alfonso, additional, Bahamonde-Carrasco, Alberto, additional, Smithson Amat, Alejandro, additional, Vinuesa García, David, additional, Herrero Rodríguez, Carmen, additional, Reche Molina, Isabel María, additional, Pérez Camacho, Inés, additional, Sánchez-Porto, Antonio, additional, Guzmán García, Marcos, additional, Becerril Carral, Berta, additional, Merino de Lucas, Esperanza, additional, López-Hernández, Inmaculada, additional, Rodríguez-Baño, Jesús, additional, and López-Cortés, Luis Eduardo, additional
Published: 2021
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14. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study

Author: Gutiérrez-Gutiérrez, Belén, primary, del Toro, María Dolores, additional, Borobia, Alberto M, additional, Carcas, Antonio, additional, Jarrín, Inmaculada, additional, Yllescas, María, additional, Ryan, Pablo, additional, Pachón, Jerónimo, additional, Carratalà, Jordi, additional, Berenguer, Juan, additional, Arribas, Jose Ramón, additional, Rodríguez-Baño, Jesús, additional, Aznar Muñoz, Esther, additional, Gil Divasson, Pedro, additional, González Muñiz, Patricia, additional, Muñoz Aguirre, Clara, additional, Retamar, Pilar, additional, Valiente, Adoración, additional, López-Cortés, Luis E., additional, Sojo-Dorado, Jesús, additional, Bravo-Ferrer, José, additional, Salamanca, Elena, additional, Palacios-Baena, Zaira R., additional, Pérez-Palacios, Patricia, additional, Gandullo-Moro, María, additional, Ruíz-Hueso, Rocío, additional, Moya-González, Natalia, additional, Valido-Morales, Agustín, additional, Pavón-Masa, María, additional, Díaz Menéndez, Marta, additional, De la Calle Prieto, Fernando, additional, Arsuaga Vicente, Marta, additional, Trigo Esteban, Elena, additional, De Miguel Buckley, Rosa, additional, Cadiñanos Loidi, Julen, additional, Busca Arenzana, Carmen, additional, Mican Rivera, Rafael, additional, Mora Rillo, Marta, additional, Loeches Yagüe, Belén, additional, Bernardino de la Serna, José Ignacio, additional, García Rodríguez, Julio, additional, Montejano Sánchez, Rocío, additional, Diaz Pollan, Beatriz, additional, López, Juan Carlos, additional, Ramírez-Schacke, Margarita, additional, Gutiérrez, Isabel, additional, Tejerina, Francisco, additional, Aldámiz-Echevarría, Teresa, additional, Díez, Cristina, additional, Fanciulli, Chiara, additional, Pérez-Latorre, Leire, additional, Parras, Francisco, additional, Catalán, Pilar, additional, García-Leoni, María E, additional, Pérez-Tamayo, Isabel, additional, Puente, Luis, additional, Cedeño, Jamil, additional, Such-Diaz, Ana, additional, Álvaro-Alonso, Elena, additional, Izquierdo-García, Elsa, additional, Torres-Macho, Juan, additional, Cuevas, Guillermo, additional, Notario, Helena, additional, Mestre-Gómez, Beatriz, additional, Jiménez-González de Buitrago, Eva, additional, Fernández-Jiménez, Inés, additional, Tebar-Martínez, Ana Josefa, additional, Brañas, Fátima, additional, Valencia, Jorge, additional, Pérez-Butragueño, Mario, additional, Alvarado, Marta, additional, Abelenda-Alonso, Gabriela, additional, Ardanuy, Carmen, additional, Bergas, Alba, additional, Cuervo, Guillermo, additional, Domínguez, María Ángeles, additional, Fernández-Huerta, Miguel, additional, Gudiol, Carlota, additional, Lorenzo-Esteller, Laia, additional, Niubó, Jordi, additional, Pérez-Recio, Sandra, additional, Podzamczer, Daniel, additional, Pujol, Miquel, additional, Rombauts, Alexander, additional, Trullen, Núria, additional, Cisneros, José Miguel, additional, Amodeo, Cristina, additional, Camacho, Pedro, additional, Espinosa, Nuria, additional, García-Gutiérrez, Manuel, additional, Jara-Palomares, Luis, additional, González-León, Rocío, additional, Molina, José, additional, Nieto Martín, María Dolores, additional, Paniagua, María, additional, Poyato, Manuel, additional, Rodríguez-Villodres, Ángel, additional, Ruiz de Azua, Zaida, additional, Salamanca, Celia, additional, Sepúlveda Berrocal, Mº Antonia, additional, Yera Bergua, Carmen, additional, Toledano Sierra, Pilar, additional, Cano Llorente, Verónica, additional, Zafar Iqubal-Mirza, Sadaf, additional, Muñiz, Gema, additional, Martín Pérez, Inmaculada, additional, Mozas Moriñigo, Helena, additional, Alguacil, Ana, additional, García Butenegro, María Paz, additional, Peláez Ballesta, Ana Isabel, additional, Morcillo Rodríguez, Elena, additional, Goikoetxea Agirre, Josune, additional, Blanco Vidal, María José, additional, Nieto Arana, Javier, additional, del Álamo Martínez de Lagos, Mikel, additional, Pérez Hernández, Isabel A., additional, Pérez Zapata, Inés, additional, Silvariño Fernández, Rafael, additional, Ugalde Espiñeira, Jon, additional, Rivas-Carmenado, María, additional, Suárez Pérez, Lucia, additional, Suárez Diaz, Silvia, additional, Yllera Gutiérrez, Carmen, additional, Boix, Vicente, additional, Díez Martínez, Marcos, additional, Carreres Candela, Melissa, additional, Gómez-Ayerbe, Cristina, additional, Sánchez-Lora, Javier, additional, Velasco Garrido, José Luis, additional, López-Jodar, María, additional, Santos González, Jesús, additional, Ruiz Aragón, Jesús, additional, Virto Peña, Ianire, additional, Alende Castro, Vanessa, additional, Sande Llovo, Diana, additional, Vega Molpeceres, Sonia, additional, Pons Viñas, Estel, additional, del Río Pérez, Oscar, additional, Valero Rovira, Silvia, additional, Villar-García, Judit, additional, Gómez-Junyent, Joan, additional, Cánepa, María Cecilia, additional, Castañeda Espinosa, Silvia, additional, Letang, Emilio, additional, Arenas-Miras, María del Mar, additional, Gómez-Zorrilla, Silvia, additional, Sánchez Martínez, Francesca, additional, Lerma-Chippirraz, Elisabet, additional, García Vázquez, Elisa, additional, Moral Escudero, Encarnación, additional, Roura Piloto, Aychel Elena, additional, García Almodóvar, Esther, additional, Sáez Barberá, Carmen, additional, Karroud, Zineb, additional, Hernández Quero, José, additional, Vinuesa García, David, additional, García Fogeda, José Luis, additional, Peregrina, José Antonio, additional, Novella Mena, María, additional, Hernández Gutiérrez, Cristina, additional, Sanz Moreno, José, additional, Pérez Tanoira, Ramón, additional, Navarro López, Jorge, additional, Balsa Vázquez, Javier, additional, Gutiérrez García, Aida, additional, Arranz Caso, Alberto, additional, Cuadros González, Juan, additional, Álvarez de Mon Soto, Melchor, additional, Díaz De Brito Fernández, Vicente Ferrer, additional, Sanmarti Vilamala, Montserrat, additional, Gabarrell Pascuet, Aina, additional, Molina Morant, Daniel, additional, España Cueto, Sergio, additional, Cámara Fernández, Jonathan, additional, Sabater Gil, Albert, additional, Muñoz López, Laura, additional, Jorge García, Ruth, additional, Molina Torres, Nora, additional, Sempere Alcocer, Marco Antonio, additional, De Castro Vega, Francisco Javier, additional, De los Santos Gil, Ignacio, additional, García-Fraile, Lucio, additional, Sampedro Núñez, Miguel, additional, Barrios Blandino, Ana, additional, Rodríguez Franco, Carlos, additional, Useros Brañas, Daniel, additional, Villa Martí, Almudena, additional, Oliver Ortega, Javier, additional, Costanza Espiño Álvarez, Alexia, additional, Sanz Sanz, Jesús, additional, Rexach Fumaña, María, additional, Policarpo Torres, Guillem, additional, Ortega Montoliu, Meritxell, additional, Sala Jofre, Clara, additional, Casas Rodríguez, Susana, additional, Tortajada Alamilla, Cecilia, additional, Oltra, Carmina, additional, Masiá Canuto, Mar, additional, Gutiérrez Rodero, Félix, additional, Oltra Sempere, María Rosa, additional, Vela Berna, Sara, additional, Pedromingo Kus, Miguel, additional, Garcinuño, María Ángeles, additional, De la Vega, Alexandra, additional, Pérez Pinto, Sergio, additional, Hernández Machín, Pilar, additional, Alastrué Violeta, Alba, additional, Fariñas Álvarez, María Carmen, additional, González Rico, Claudia, additional, Arnaiz de las Revillas, Francisco, additional, Calvo, Jorge, additional, Gozalo, Mónica, additional, Mora Gómez, Francisco, additional, Milagro Beamonte, Ana, additional, Latorre-Millán, Miriam, additional, Rezusta López, Antonio, additional, Martínez Sapiña, Ana, additional, Meije, Yolanda, additional, Ribera Puig, Alba, additional, Ortega Enciso, Lucía, additional, Sanz Salvador, Xavier, additional, Losa García, Juan Emilio, additional, Velasco Arribas, María, additional, Pérez-Rodríguez, M. Teresa, additional, Pérez González, Alexandre, additional, Belhassen-García, Moncef, additional, Rodríguez-Alonso, Beatriz, additional, López-Bernus, Amparo, additional, Carbonell, Cristina, additional, Torres Perea, Rafael, additional, Cantón De Seoane, Juan, additional, Alonso, Blanca, additional, Kamal, Sara Lidia, additional, Cajuela, Lucía, additional, Roa, David, additional, Cervero, Miguel, additional, Oreja, Alberto, additional, Avilés, Juan Pablo, additional, Martín, Lidia, additional, Pelegrín Senent, Iván, additional, Rouco Esteves Marques, Rosana, additional, Parra Ruiz, Jorge, additional, Ramos Sesma, Violeta, additional, Abadia Otero, Jésica, additional, Salillas Hernando, Juan, additional, Torres Sánchez del Arco, Robert, additional, Torralba González de Suso, Miguel, additional, Serrano Martínez, Alberto, additional, Gilaberte Reyzábal, Sergio, additional, Pacheco Martínez-Atienza, Marina, additional, Liébana Gómez, Mónica, additional, Fernández Rodríguez, Sara, additional, Varela Plaza, Álvaro, additional, Calvo Sánchez, Henar, additional, Martínez Martín, Patricia, additional, González- Ruano, Patricia, additional, Malmierca Corral, Eduardo, additional, Rábago Lorite, Isabel, additional, Pérez-Monte Mínguez, Beatriz, additional, García Flores, Ángeles, additional, Comas Casanova, Pere, additional, Sirisi, Merce, additional, Rojas, Richard, additional, Díaz de Tuesta del Arco, José Luis, additional, Figueroa Cerón, Ruth, additional, González Sarria, Ander, additional, Alemán Valls, Remedios, additional, Alonso Socas, María del Mar, additional, Sanz Peláez, Oscar, additional, Mohamed Ramírez, Karim, additional, Riera Jaume, Melchor, additional, Vilchez, Helem Haydee, additional, Albertí, Francesc, additional, Cañabate, Ana Isabel, additional, Moreno Cuerda, Víctor J, additional, Álvarez Kaelis, Silvia, additional, Álvarez Zapatero, Beatriz, additional, García García, Alejandro, additional, Isaba Ares, Elena, additional, Morcate Fernández, Covadonga, additional, Pérez Rodríguez, Andrea, additional, Ramos Merino, Lucía, additional, Castelo Corral, Laura, additional, Rodríguez Mahía, María, additional, González Bardanca, Mónica, additional, Sánchez Vidal, Efrén, additional, Míguez Rey, Enrique, additional, Correa Ruiz, Ana, additional, García de Lomas Guerrero, José Mº, additional, Daniel López, Daniel, additional, Marinas, Rebeca, additional, Morando, Marta, additional, Gómez García, Lucía, additional, Boix Palop, Lucia, additional, Dietl Gómez-Luengo, Beatriz, additional, Pedrola Gorrea, Iris, additional, Blasco Claramunt, Amparo, additional, López Mestanza, Cristina, additional, Fraile Villarejo, Esther, additional, Jaén Sánchez, Nieves, additional, Orihuela Martín, Jorge, additional, Algado Rabasa, José Tomas, additional, Garijo Saiz, Ana María, additional, Amador Prous, Concepción, additional, Salavert Lletí, Miguel, additional, Hernández Belmonte, Adriana, additional, Martínez Goñi, Raquel, additional, Navarro Vilasaró, Marta, additional, Calzado Isbert, Sonia, additional, Cervantes García, Manuel, additional, Gomila Grange, Aina, additional, Gasch Blasi, Oriol, additional, Machado Sicilia, María Luisa, additional, Van den Eynde Otero, Eva, additional, Falgueras López, Luis, additional, Navarro Sáez, María del Carmen, additional, Martínez, Esteban, additional, Marcos, Mº Ángeles, additional, Mosquera, Mar, additional, Blanco, José Luis, additional, Laguno, Montserrat, additional, Rojas, Jhon, additional, González-Cordón, Ana, additional, Inciarte, Alexy, additional, Torres, Berta, additional, De la Mora, Lorena, additional, Soriano, Alex, additional, Martínez Macia, Olalla, additional, Pérez Doñate, Virginia, additional, Cabello Úbeda, Alfonso, additional, Carrasco Antón, Nerea, additional, Álvarez Álvarez, Beatriz, additional, Petkova Saiz, Elizabet, additional, Górgolas Hernández-Mora, Miguel, additional, Prieto Pérez, Laura, additional, Carrillo Acosta, Irene, additional, Heili Frades, Sara, additional, Villar Álvarez, Felipe, additional, Fernández Roblas, Ricardo, additional, Sánchez Pernaute, Olga, additional, Fernández Espinilla, Virginia, additional, Castrodeza Sanz, José Javier, additional, Dueñas Gutiérrez, Carlos Jesús, additional, González-Romo, Fernando, additional, Merino Amador, Paloma, additional, Rueda López, Alba, additional, Martínez Jordán, Jorge, additional, Medrano Pardo, Sara, additional, Díaz de la Torre, Irene, additional, Posada Franco, Yolanda, additional, Delgado-Iribarren, Alberto, additional, López-Contreras González, Joaquín, additional, Pascual Alonso, Pablo, additional, Pomar Solchaga, Virginia, additional, Rabella García, Nuria, additional, Benito Hernández, Natividad, additional, Domingo Pedrol, Pere, additional, Bonfill Cosp, Xavier, additional, Padrós Selma, Rafael, additional, Puig Campmany, Mireia, additional, Mancebo Cortés, Jordi, additional, Gurguí Ferrer, Mercè, additional, Íñigo Pestaña, Melania, additional, Pérez García, Alejandra, additional, Sorní Moreno, Patricia, additional, Izko Gartzia, Nora, additional, Membrillo de Novales, Francisco Javier, additional, Simón Sacristán, María, additional, Zamora Cintas, Maribel, additional, Martínez Martínez, Yolanda, additional, Estébanez Muñoz, Miriam, additional, Ramírez-Olivencia, Germán, additional, Herrero Mendoza, María Dolores, additional, De Dios García, Begoña, additional, Mata Forte, Tatiana, additional, Rodríguez Fernández, José María, additional, Sáez de Adana Arróniz, Ester, additional, Portu Zapirain, Joseba, additional, Gainzarain Arana, Juan Carlos, additional, Ortiz de Zárate Ibarra, Zuriñe, additional, Moran Rodríguez, Miguel Ángel, additional, Canut Blasco, Andrés, additional, Hernáez Crespo, Silvia, additional, Sanjosé Muñiz, Irene, additional, Molina Iturritza, Estíbaliz, additional, Ganchegui Aguirre, Maite, additional, Urrestarazu Larrañag, Miren, additional, De la Higuera Arranz, Carmen, additional, Álvarez Padín, Pilar, additional, Iglesias Llorente, Laura, additional, Román Bernal, Berta, additional, Sánchez Montalvá, Adrián, additional, Espinosa Pereiro, Juan, additional, Almirante, Benito, additional, Miarons, Marta, additional, Sellarés, Júlia, additional, Larrosa, María, additional, Villamarín, Miguel, additional, Fernández, Nuria, additional, Salvador, Fernando, additional, Bosch-Nicolau, Pau, additional, Pérez-Jorge Peremarch, Conchita, additional, Resino Foz, Elena, additional, Espigares Correa, Andrea, additional, Álvarez de Espejo Montiel, Teresa, additional, Navas Clemente, Iván, additional, Quijano Contreras, María Isabel, additional, Nieto Fernández del Campo, Luis Alberto, additional, Jiménez Álvarez, Guillermo, additional, Guillamón Sánchez, Mercedes, additional, García García, Josefina, additional, Muñoz Hornero, Constanza, additional, Cosmen Sánchez, Ana, additional, Mariño Callejo, Ana, additional, Valcarce Pardeiro, Nieves, additional, Smithson Amat, Alex, additional, Chico Chumillas, Cristina, additional, Sánchez Serrano, Adriana, additional, Piñar Cabezos, Diana, additional, Jiménez Martínez, Isabel, additional, Estrada Fernández, Guillermo, additional, Lorén Vargas, María, additional, Parra Arribas, Nuria, additional, Martínez Cilleros, Carmen, additional, Villasante de la Puente, Aránzazu, additional, García Delange, Teresa, additional, Ruiz Rodríguez, María José, additional, Robledo del Prado, Marta, additional, Abad Almendro, Juan Carlos, additional, Muñoz del Rey, José Román, additional, Jiménez Álvaro, Montaña, additional, Coy Coy, Javier, additional, Poquet Catala, Inmaculada, additional, Santos Peña, Marta, additional, Mora Delgado, Juan, additional, Manso Gómez, Tamara, additional, Rubio Obanos, Teresa, additional, Barbeito Castiñeiras, Gema, additional, Domínguez Santalla, María Jesús, additional, Mao Martín, Laura, additional, Adalid Moll, María, additional, Díaz Luperena, Javier, additional, Ruiz Grinspan, Martín Sebastián, additional, Barrós González, Raquel, additional, Herrera Pacheco, Lourdes, additional, Martínez Avilés, Rocío, additional, Rodrigo González, Sara, additional, Rodríguez Leal, Cristóbal Manuel, additional, Romay Lema, Eva María, additional, Suárez Gil, Roi, additional, Bustinduy Odriozola, Maria Jesús, additional, Marimón Ortiz de Zárate, José María, additional, Vidaur Tello, Loreto, additional, Kortajarena Urkola, Xabier, additional, Arriola Martínez, Paula, additional, Lartategi Iraurgi, Alazne, additional, Álvarez de Castro, Maria, additional, Martínez Mateu, Cintia María, additional, Rodríguez Gómez, Francisco, additional, Asschert Agüero, Isabel, additional, Chamarro Martí, Elena, additional, Franch Llasat, Diego, additional, Zakariya-Yousef Breval, Ismail, additional, Rico Rodríguez, Marta, additional, Martínez López, Belén, additional, García-López, María, additional, Fernández Cruz, Ana, additional, Calderón Parra, Jorge, additional, Ramos Martínez, Antonio, additional, Múñez Rubio, Elena, additional, Vázquez Comendador, José Manuel, additional, Diego Yagüe, Itziar, additional, Expósito Palomo, Esther, additional, Díaz de Santiago, Alberto, additional, De la Fuente Moral, Sara, additional, Pintos Pascual, Ilduara, additional, Álvarez Franco, Raquel, additional, Fernández de Orueta, Lucía, additional, Vates Gómez, Roberto, additional, Cardona Arias, Andrés Felipe, additional, Marguenda Contreras, Pablo, additional, Gaspar Alonso-Vega, Gabriel, additional, Aranda Rife, Elena María, additional, Martínez Cifre, Blanca, additional, Roger Zapata, Daniel, additional, Martín Rubio, Irene, additional, Barbosa Ventura, André, additional, Piñero, Iván, additional, Bahamonde Carrasco, Alberto, additional, Martínez Vidal, Ana, additional, Talavera García, Eva, additional, Mendoza Roy, Paula, additional, Urrutia Losada, Ainhoa, additional, Arteche Eguizabal, Lorea, additional, Delgado Sánchez, Elisabet, additional, Bañón Escandell, Sara, additional, Caro Bragado, Sarah, additional, Domínguez de Pablos, Gema, additional, Herrero Rodríguez, Carmen, additional, Liébana Martos, Carmen, additional, Force Sanmartín, Luis, additional, Aranega, Raquel, additional, Mera Fidalgo, Arantzazu, additional, Hortos Alsina, Miquel, additional, Merchante Gutiérrez, Nicolas, additional, León Jiménez, Eva María, additional, Del Pozo, José L, additional, Serralta Buades, Josefa, additional, Cabrera Tejada, Ginger Giorgiana, additional, Fernández-Ruiz, Mario, additional, Aguado, José María, additional, Maestro de la Calle, Guillermo, additional, Vizcarra, Pilar, additional, Rodriguez Dominguez, Mario José, additional, Gioia, Francesca, additional, Del Campo, Santos, additional, Cantón Moreno, Rafael, additional, Martín Dávila, Pilar, additional, Casado, José Luis, additional, Oteo Revuelta, José Antonio, additional, Santibáñez Sáenz, Paula, additional, Cervera Acedo, Cristina, additional, Ruiz Martínez, Carlos, additional, Blanco Ramos, José Ramón, additional, Azcona Gutiérrez, José M., additional, García García, Concepción, additional, Alba Fernández, Jorge, additional, Ibarra Cucalón, Valvanera, additional, San Franco, Mercedes, additional, Metola Sacristán, Luis, additional, Meijide Míguez, Héctor, additional, Gredilla Zubiría, Íñigo, additional, Menéndez, Justo, additional, Villares Fernández, Paula, additional, Montes Andújar, Lara, additional, Navarro Batet, Álvaro, additional, Ferrer Santolaria, Anna, additional, Padilla Salazar, María de la Luz, additional, Abella Vázquez, Lucy, additional, Hayek Peraza, Marcelino, additional, García Pardo, Antonio, additional, Hernández Carballo, Carolina, additional, Ruiz Fernández, Andrés Javier, additional, Barrio López, Isabel, additional, Martakoush, Alí, additional, Rojas-Vieyra, Agustín, additional, García Calvo, Sonia, additional, Villarreal García-Lomas, Mercedes, additional, Vizcaíno Callejón, Marta, additional, García García, María Pilar, additional, Lérida Urteaga, Ana, additional, Carrasco Fons, Natalia, additional, María Sanjuan, Beatriz, additional, Martín González, Lydia, additional, Sanz Zamudio, Camilo, additional, Alejos, Belén, additional, Moreno, Cristina, additional, Rava, Marta, additional, Iniesta, Carlos, additional, Izquierdo, Rebeca, additional, Suárez-García, Inés, additional, Díaz, Asunción, additional, Ruiz-Alguero, Marta, additional, Hernando, Victoria, additional, Frías, Jesús, additional, Ramírez, Elena, additional, Martín-Quirós, Alejandro, additional, Quintana-Díaz, Manuel, additional, Mingorance, Jesús, additional, Arnalich, Francisco, additional, Moreno, Francisco, additional, Figueiras, Juan Carlos, additional, García-Arenzana, Nicolás, additional, Montero-Vega, María Dolores, additional, Romero-Gómez, María Pilar, additional, Toro-Rueda, Carlos, additional, García-Bujalance, Silvia, additional, Ruiz-Carrascosa, Guillermo, additional, Cendejas-Bueno, Emilio, additional, Falces-Romero, Iker, additional, Lázaro-Perona, Fernando, additional, Ruiz-Bastián, Mario, additional, Gutiérrez-Arroyo, Almudena, additional, Girón De Velasco-Sada, Patricia, additional, Dahdouh, Elie, additional, Gómez-Arroyo, Bartolomé, additional, García-Sánchez, Consuelo, additional, Guedez-López, Virginia, additional, Bloise-Sánchez, Iván, additional, Alguacil-Guillén, Marina, additional, Liras-Hernández, Maria Gracia, additional, Sánchez-Castellano, Miguel Angel, additional, García-Clemente, Paloma, additional, González-Donapetry, Patricia, additional, San José-Villar, S, additional, de Pablos-Gómez,, Manuela, additional, Gómez-Gil, Rosa, additional, Corcuera-Pindado, Maria Teresa, additional, Rico-Nieto, Alicia, additional, Herrero, Alicia, additional, Prieto-Arribas, Daniel, additional, Oliver-Saez, Paloma, additional, Mora-Corcovado, Roberto, additional, Fernández-Calle, Pilar, additional, Alcaide-Martín, María José, additional, Díaz-Garzón, Jorge, additional, Fernández-Puntero, Belén, additional, Nuñez-Cabetas, Rocío, additional, Crespo-Sánchez, Gema, additional, Rodriguez-Fraga, Olaia, additional, Mendez del Sol, Helena, additional, Duque-Alcorta, Marta, additional, Gomez-Rioja, Rubén, additional, Sanz de Pedro, María, additional, Pascual-García, Lydia, additional, Segovia-Amaro, Marta, additional, Iturzaeta-Sánchez, Jose Manuel, additional, Rodriguez-Gutiérrez, Mercedes, additional, Perez-Garcia Morillón, Amparo, additional, Martinez Gallego, Miguel Angel, additional, Fabre-Estremera, Blanca, additional, Martinez-Chavez, Estefanía, additional, Moreno-Parra, Isabel, additional, Rodriguez-Roca, Neila, additional, Ortiz-Sánchez, Daniel, additional, Simon-Velasco, Manuela, additional, Gabriela-Tomoiu, Ileana, additional, Pizarro-Sanchez, Cristina, additional, Montero-San Martín, Blanca, additional, Qasem-Moreno, Ana Laila, additional, Gómez-López, Marta, additional, Casares Guerrero, Ismael, additional, Buño-Soto, Antonio, additional, Martí de Gracia, Milagros, additional, Parra-Gordo, Luz, additional, Diez-Tascón, Aurea, additional, Ossaba-Vélez, Silvia, additional, Pinilla, Inmaculada, additional, Cuesta, Emilio, additional, Fernández-Velilla, María, additional, Torres, Maria Isabel, additional, Garzón, Gonzalo, additional, Pérez-Blanco, Verónica, additional, Quintás-Viqueira, Almudena, additional, San Juan, Isabel, additional, Cantero-Escribano, José Miguel, additional, Pérez-Romero, César, additional, Castro-Martínez, Mercedes, additional, Hernández-Rivas, Lucía, additional, Pedraz, Teresa, additional, Fernández-Bretón, Eva, additional, García-Vaz, Claudia, additional, Robustillo-Rodela, Ana, additional, Torres Santos-Olmo, Rosario María, additional, Rivera-Núñez, Angélica, additional, Fernández-Fernández, Ignacio, additional, Noguerol-Gutiérrez, Marina, additional, Martínez-Virto, Ana María, additional, González-Viñolis, Manuel, additional, Cabrera-Gamero, Regina, additional, Mayayo-Alvira, Rosa, additional, Marín-Baselga, Raquel, additional, Lo-Iacono García, Victoria, additional, Lerín-Baratas, Macarena, additional, Romero Gallego-Acho, Paloma, additional, Reche-Martínez, Begoña, additional, Tejada-Sorados, Renzo, additional, Rico-Briñas, Mikel, additional, Deza-Palacios, Ricardo, additional, Fabra-Cadenas, Sara, additional, Arroyo-Rico, Isabel, additional, Ben-Abdellah, Lubna Dani, additional, Labajo-Montero, Laura, additional, Soriano-Arroyo, Rubén, additional, López-Corcuer, Lorena, additional, Calvin-García, Elena, additional, Martínez-Álvarez, Susana, additional, López-Tappero Irazábal, Laura, additional, Pilares-Barco, Martín, additional, González-Peña, Olga, additional, Bejarano-Redondo, Guillermina, additional, Iglesias-Sigüenza, Alberto, additional, Tung-Chen, Yale, additional, Maroun Eid, Charbel, additional, Bravo-Lizcano, Ruth, additional, Silvestre-Niño, Miguel, additional, Perdomo-García, Frank, additional, Alonso-González, Berta, additional, Antón-Huguet, Berta, additional, Arenas-Berenguer, Isabel, additional, Cabré-Verdiell Surribas, Clara, additional, Marqués-González, Francisco, additional, Muñoz del Val, Elena, additional, Ángeles Molina, María, additional, Cancelliere-Fernández, Nataly, additional, Pastor-Yvorra, Sivia, additional, Frade-Pardo, Laura, additional, López-Arévalo, Paloma, additional, García, Isabel, additional, Fernández-Capitán, Carmen, additional, González-Garcia, Juan José, additional, Herrero, Juan, additional, Quesada Simón, María Angustias, additional, Robles Marhuenda, Angel, additional, Soto Abanedes, Clara, additional, Noblejas Mozo, Ana María, additional, Ramos, Juan Carlos, additional, Jaras Hernandez, María Jesús, additional, Martinez Robles, Elena, additional, Moreno Fernandez, Alberto, additional, Sanchez Purificación, Aquilino, additional, Martin Gutiérrez, Juan Carlos, additional, Martinez Hernández, Pedro Luis, additional, Sancho Bueso, Teresa, additional, Lorenzo Hernández, Alicia, additional, Gutierrez Sancerni, Belén, additional, Salgueiro, Giorgina, additional, Martin Carbonero, Luz, additional, Mostaza, Jose María, additional, Martinez-López, María Angeles, additional, Hontañón, Victor, additional, Menéndez, Araceli, additional, Alvarez Troncoso, Jorge, additional, Castellano, Arancha, additional, Marcelo-Calvo, Cristina, additional, Vives-Beltrán, Ivo, additional, Ramos Ruperto, Luis, additional, Daroca-Bengoa, Germán, additional, Arcos Rueda, María, additional, Vasquez-Manau, Julia, additional, Fernández Cidón, Pelayo, additional, Rosario Herrero Gil, Carmen, additional, Palmier Peláez, Esmeralda, additional, Untoria Tabares, Yeray, additional, Lahoz, Carlos, additional, Estirado, Eva, additional, Hernández, Clara, additional, Garcia-Iglesias, Francisca, additional, Monteoliva, Enrique, additional, Martínez, Mónica, additional, Vara, Marta, additional, González Alegre, Teresa, additional, Valencia, Maria Eulalia, additional, Moreno, Victoria, additional, Montes, Maria Luisa, additional, Alcolea-Batres, Sergio, additional, Cabanillas-Martín, Juan José, additional, Carpio-Segura, Carlos, additional, Casitas-Mateo, Raquel, additional, Fernández-Bujarrabal Villoslada, Jaime, additional, Fernández-Navarro, Isabel, additional, Fernández-Lahera, Juan, additional, García-Quero, Cristina, additional, Hidalgo-Sánchez, María, additional, Galera-Martínez, Raúl, additional, García-Río, Francisco, additional, Gómez-Carrera, Luis, additional, Gómez-Mendieta, María Antonia, additional, Mangas-Moro, Alberto, additional, Martínez-Cerón, Elisabet, additional, Martínez-Redondo, María, additional, Martínez-Abad, Yolanda, additional, Martínez-Verdasco, Antonio, additional, Plaza-Moreno, Cristina, additional, Quirós-Fernández, Sarai, additional, Romera-Cano, Delia, additional, Romero-Ribate, David, additional, Sánchez-Sánchez, Begoña, additional, Santiago-Recuerda, Ana, additional, Villasante, Carlos, additional, Zamarrón de Lucas, Ester, additional, Arnalich-Montiel, Victoria, additional, Mariscal-Aguilar, Pablo, additional, Falcone, Adalgisa, additional, Laorden-Escudero, Daniel, additional, Prados Sánchez, María Concepción, additional, Álvarez-Sala Walther, Rodolfo, additional, García, Andony, additional, Arévalo, Cristina, additional, Gutiérrez, Carola, additional, Yus, Santiago, additional, Asensio, Maria José, additional, Sánchez, Manolo, additional, Añón, Jose Manuel, additional, Manzanares, Jesús, additional, García de Lorenzo, Abelardo, additional, Perales, Eva, additional, Civantos, Belén, additional, Cachafeiro, Lucía, additional, Agrifoglio, Alexander, additional, Estébanez, Belén, additional, Flores, Eva, additional, Hernández, Mónica, additional, Millán, Pablo, additional, Rodríguez, Montserrat, additional, Nanwani, Kapil, additional, Arizcun, Beatriz, additional, Pérez-Costa, Elena, additional, Rodríguez-Álvarez, Diego, additional, Sánchez-Martín, María, additional, Quesada, Úrsula, additional, Román-Hernández, Carmen, additional, Dorao, Paloma, additional, Álvarez-Rojas, Elena, additional, Menéndez, Juan José, additional, Verdú, Cristina, additional, Gómez-Zamora, Ana, additional, Schüffelmann, Cristina, additional, Calderón-Llopis, Belén, additional, Laplaza-González, María, additional, Río-García, Miguel, additional, Amores-Hernández, Irene, additional, Rodríguez-Rubio, Miguel, additional, de la Oliva, Pedro, additional, Ruiz, Jose, additional, Rosillo, Sandra, additional, González, Oscar, additional, Iniesta, Angel, additional, Ponz, Ines, additional, Muñoz-Ramón, José María, additional, Hernández-Gancedo, María, additional, Uña Orejón, Carmen R., additional, Sanabria-Carretero, Pascual, additional, Moreno Gómez-Limón, Isidro, additional, Seiz-Martinez, Alverio, additional, Guasch-Arévalo, Emilia, additional, Martín-Carrasco, Cristina, additional, Alvar, Elena, additional, Serrá, Lucía, additional, Iannuccelli, Fabricio, additional, Latorre, Julieta, additional, Casares, Sandra, additional, Valbuena, Isabel, additional, Díaz Díez Picazo, Luis, additional, Rodríguez Roca, Cristina, additional, Cervera, Omar, additional, García de las Heras, Esteban, additional, Durán, Pilar, additional, Castro, Carmen, additional, Manrique de Lara, Carlos, additional, Veganzones, Javier, additional, López-Tofiño, Araceli, additional, Fernandez-Cerezo, Estefanía, additional, Zurita, Sergio, additional, López-Martinez, Mercedes, additional, Prim, Teresa, additional, Alvárez del Vayo, Julía, additional, Alcaraz, Gabriela, additional, Castro, Luis, additional, Yagüe, Julio, additional, Díaz-Carrasco, Sofía, additional, González-Pizarro, Patricio, additional, Montero, Ana, additional, Sagra, Francisco Javier, additional, Suárez, Alejandro, additional, Díez-Porres, Leyre, additional, Varela-Cerdeira, María, additional, Alonso-Babarro, Alberto, additional, Abellán Martínez, Francisco, additional, Alonso-Eiras, Jorge Ignacio, additional, Álvarez Brandt, Alejandra, additional, Archinà, Martina, additional, Arribas-Terradillos, Silvia, additional, Baselga-Puente, Trinidad, additional, Barco Núñez, Pilar, additional, Barrera-López, Natalia Guadalupe, additional, Barrera-López, Lorena, additional, Bartrina-Tarrio, Andres, additional, Bassani, Gemma, additional, Betancort de la Torre, Paula, additional, Blanco-Bartolomé, Irene, additional, Blasco-Andres, Celia, additional, Brieba-Plata, Lucía, additional, Cadenas-Gota, Fernando, additional, Carrera-Vázquez, Paloma, additional, Cascajares-Sanz, Carlota, additional, Catino, Arianna, additional, Cavallé-Pulla, Raquel, additional, Ceniza-Pena, Daniel, additional, Conde-Alonso, Ylenia María, additional, Currás-Sánchez, Laura, additional, Daltro-Lage, Marcelo, additional, Esteban-Romero, Ana, additional, Fernández Vidal, María Luisa, additional, Ferrer Ortiz, Inés, additional, de la Fuente Regaño, Lydia, additional, Galindo-Ballesteros, Pablo, additional, Garcia-Bellido Ruiz, Sara, additional, García-Mochales Fortún, Carlos, additional, Gómez-Ballesteros, Teresa, additional, Gómez-Domínguez, Cecilia, additional, González-Aguado, Nelsa, additional, González-García, Sofía, additional, Guisández Martín, Jorge, additional, Hernández-Liebo, Paula Alejandra, additional, Hernando Nieto, Raquel, additional, Llorente-Cortijo, Irene María, additional, Marín-García, Antonio, additional, López-Pirez, Pilar, additional, Mejuto-Illade, Lucía, additional, Palma, Marco, additional, Peña-Hidalgo, Adrian, additional, Platero-Dueñas, Lucía, additional, Pujol-Pocull, David, additional, Ramírez-Verdyguer, Miguel, additional, Redondo-Gutierrez, Marta, additional, Reinoso-Lozano, Francisco, additional, Rodríguez-Revillas, Ana, additional, Rodríguez Saenz de Urturi, Alejandro, additional, Romero-Imaz, Lucía, additional, Sánchez-Rico, Susana, additional, Sánchez-Santiuste, Mónica, additional, Serrano de la Fuente, Patricia, additional, Serrano-Martín, Henar, additional, Silva-Freire, Thamires, additional, Soria-Alcaide, Eva, additional, Suárez-Plaza, Andrés Enrique, additional, Tejero-Soriano, Beatriz, additional, Torrecillas-Mainez, Andrea, additional, Torres-Cortés, Javier, additional, Valentín-Pastrana Aguilar, María de las Mercedes, additional, Villanueva-Freije, Angélica, additional, Virgós-Varela, Marta, additional, Yagüe-Barrado, Marta, additional, Yustas-Benitez, Natalia, additional, Nuñez, María Concepción, additional, Montserrat, Jaime, additional, Queiruga, Javier, additional, Rodriguez-Mariblanca, Amelia, additional, Martínez de Soto, Lucía, additional, Urroz, Mikel, additional, Seco, Enrique, additional, Zubimendi, Mónica, additional, Stuart, Stephan, additional, Díaz, Lucía, additional, García, Irene, additional, García Morales, María Teresa, additional, Martín-Vega, Alberto, additional, Caro, Abel, additional, and Martínez-Alés, Gonzalo, additional
Published: 2021
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15. Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

Author: Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, European Commission, Martínez Pérez-Crespo, Pedro María, Lanz-García, Joaquín, Bravo-Ferrer, José, Cantón-Bulnes, María Luisa, Sousa, Adrián, Goikoetxea-Aguirre, Josune, Reguera-Iglesias, J. M., León Jiménez, Eva, Armiñanzas Castillo, Carlos, Mantecón Vallejo, María Ángeles, Marrodán, Teresa, Fernández Suárez, Jonathan, Boix-Palop, Lucía, Cuquet Pedragosa, Jordi, Jover-Sáenz, Alfredo, Sevilla Blanco, Juan, Galán-Sánchez, Fátima, Natera Kindelán, Clara, Arco, A. del, Bahamonde-Carrasco, Alberto, Smithson Amat, Alejandro, Vinuesa García, David, Herrero Rodríguez, Carmen, Reche Molina, Isabel María, Pérez-Camacho, Inés, Sánchez-Porto, Antonio, Guzmán García, Marcos, Becerril Carral, Berta, Merino de Lucas, Esperanza, López-Hernández, Inmaculada, Rodríguez-Baño, Jesús, López-Cortés, Luis Eduardo, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, European Commission, Martínez Pérez-Crespo, Pedro María, Lanz-García, Joaquín, Bravo-Ferrer, José, Cantón-Bulnes, María Luisa, Sousa, Adrián, Goikoetxea-Aguirre, Josune, Reguera-Iglesias, J. M., León Jiménez, Eva, Armiñanzas Castillo, Carlos, Mantecón Vallejo, María Ángeles, Marrodán, Teresa, Fernández Suárez, Jonathan, Boix-Palop, Lucía, Cuquet Pedragosa, Jordi, Jover-Sáenz, Alfredo, Sevilla Blanco, Juan, Galán-Sánchez, Fátima, Natera Kindelán, Clara, Arco, A. del, Bahamonde-Carrasco, Alberto, Smithson Amat, Alejandro, Vinuesa García, David, Herrero Rodríguez, Carmen, Reche Molina, Isabel María, Pérez-Camacho, Inés, Sánchez-Porto, Antonio, Guzmán García, Marcos, Becerril Carral, Berta, Merino de Lucas, Esperanza, López-Hernández, Inmaculada, Rodríguez-Baño, Jesús, and López-Cortés, Luis Eduardo
Abstract: The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60–81 years) and 3656 (58.3%; 95% confidence interval 57.1–59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients’ profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition.
Published: 2021

16. Infections after spine instrumentation: effectiveness of short antibiotic treatment in a large multicentre cohort

Author: Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Benavent Palomares, Eva, Rodríguez-Pardo, Dolors, Ulldemolins, Marta, Sobrino-Díaz, Beatriz, Bustinduy, María Jesús, Escudero-Sánchez, Rosa, Nodar, Andrés, Sorlí, Luisa, Toro, María Dolores del, Bahamonde-Carrasco, Alberto, Vilchez, Helem H., Durán, Joan, Muñez, Elena, Rodriguez-Montserrat, David, García-País, María José, Pellisé, Ferran, Núñez-Pereira, Susana, Caballero-Martínez, Luis F., Cobo Reinoso, Javier, Pérez-Rodríguez, María Teresa, Ariza, Javier, Pigrau, Carlos, Murillo, Óscar, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Benavent Palomares, Eva, Rodríguez-Pardo, Dolors, Ulldemolins, Marta, Sobrino-Díaz, Beatriz, Bustinduy, María Jesús, Escudero-Sánchez, Rosa, Nodar, Andrés, Sorlí, Luisa, Toro, María Dolores del, Bahamonde-Carrasco, Alberto, Vilchez, Helem H., Durán, Joan, Muñez, Elena, Rodriguez-Montserrat, David, García-País, María José, Pellisé, Ferran, Núñez-Pereira, Susana, Caballero-Martínez, Luis F., Cobo Reinoso, Javier, Pérez-Rodríguez, María Teresa, Ariza, Javier, Pigrau, Carlos, and Murillo, Óscar
Abstract: [Background and objectives] Available information about infection after spine instrumentation (IASI) and its management are scarce. We aimed to analyse DAIR (debridement, antibiotics and implant retention) prognosis and evaluate effectiveness of short antibiotic courses on early forms., [Methods] Multicentre retrospective study of patients with IASI managed surgically (January 2010–December 2016). Risk factors for failure were analysed by multivariate Cox regression and differences between short and long antibiotic treatment were evaluated with a propensity score-matched analysis., [Results] Of the 411 IASI cases, 300 (73%) presented in the first month after surgery, 48 in the second month, 22 in the third and 41 thereafter. Infections within the first 2 months (early cases) occurred mainly to older patients, with local inflammatory signs and predominance of Enterobacteriaceae, unlike those in the later periods. When managed with DAIR, prognosis of early cases was better than later ones (failure rate 10.4% versus 26.1%, respectively; P = 0.02). Risk factors for DAIR failure in early cases were female sex, Charlson Score, large fusions (>6 levels) and polymicrobial infections (adjusted HRs of 2.4, 1.3, 2.6 and 2.26, respectively). Propensity score matching proved shorter courses of antibiotics (4–6 weeks) as effective as longer courses (failure rates 11.4% and 10.5%, respectively; P = 0.870)., [Conclusions] IASIs within the first 2 months could be managed effectively with DAIR and shorter antibiotic courses. Clinicians should be cautious when faced with patients with comorbidities, large fusions and/or polymicrobial infections.
Published: 2021

17. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

Author: Berenguer, Juan, primary, Ryan, Pablo, additional, Rodríguez-Baño, Jesús, additional, Jarrín, Inmaculada, additional, Carratalà, Jordi, additional, Pachón, Jerónimo, additional, Yllescas, María, additional, Arriba, José Ramón, additional, Aznar Muñoz, Esther, additional, Gil Divasson, Pedro, additional, González Muñiz, Patricia, additional, Muñoz Aguirre, Clara, additional, López, Juan Carlos, additional, Ramírez-Schacke, Margarita, additional, Gutiérrez, Isabel, additional, Tejerina, Francisco, additional, Aldámiz-Echevarría, Teresa, additional, Díez, Cristina, additional, Fanciulli, Chiara, additional, Pérez-Latorre, Leire, additional, Parras, Francisco, additional, Catalán, Pilar, additional, García-Leoni, María E., additional, Pérez-Tamayo, Isabel, additional, Puente, Luis, additional, Cedeño, Jamil, additional, Berenguer, Juan, additional, Díaz Menéndez, Marta, additional, de la Calle Prieto, Fernando, additional, Arsuaga Vicente, Marta, additional, Trigo Esteban, Elena, additional, Lago Núñez, Mª del Mar, additional, de Miguel Buckley, Rosa, additional, Cadiñaños Loidi, Julen, additional, Busca Arenzana, Carmen, additional, Mican, Alfredo, additional, Mora Rillo, Marta, additional, Ramos Ramos, Juan Carlos, additional, Loeches Yagüe, Belén, additional, Bernardino de la Serna, José Ignacio, additional, García Rodríguez, Julio, additional, Arribas López, José Ramón, additional, Such Diaz, Ana, additional, Álvaro Alonso, Elena, additional, Izquierdo García, Elsa, additional, Torres Macho, Juan, additional, Cuevas Tascon, Guillermo, additional, Troya García, Jesús, additional, Mestre Gómez, Beatriz, additional, Jiménez González de Buitrago, Eva, additional, Fernández Jiménez, Inés, additional, Tebar Martínez, Ana Josefa, additional, Brañas Baztán, Fátima, additional, Valencia de la Rosa, Jorge, additional, Pérez Butragueño, Mario, additional, Alvarado Blasco, Marta, additional, Sepúlveda Berrocal, Mª Antonia, additional, Yera Bergua, Carmen, additional, Toledano Sierra, Pilar, additional, Cano Llorente, Verónica, additional, Zafar Iqubal-Mirza, Sadaf, additional, Muñiz, Gema, additional, Martín Pérez, Inmaculada, additional, Mozas Moriñigo, Helena, additional, Alguacil, Ana, additional, García Butenegro, María Paz, additional, Peláez Ballesta, Ana Isabel, additional, Morcillo Rodríguez, Elena, additional, Goikoetxea Agirre, Josune, additional, Blanco Vidal, María José, additional, Nieto Arana, Javier, additional, del Álamo Martínez de Lagos, Mikel, additional, Pérez Hernández, Isabel A., additional, Pérez Zapata, Inés, additional, Silvariño Fernández, Rafael, additional, Ugalde Espiñeira, Jon, additional, Asensi Álvarez, Víctor, additional, Suárez Pérez, Lucia, additional, Suárez Diaz, Silvia, additional, Yllera Gutiérrez, Carmen, additional, Boix, Vicente, additional, Díez Martínez, Marcos, additional, Carreres Candela, Melissa, additional, Gómez-Ayerbe, Cristina, additional, Sánchez-Lora, Javier, additional, Velasco Garrido, José Luis, additional, López-Jódar, María, additional, Santos González, Jesús, additional, Ruiz Aragón, Jesús, additional, Virto Peña, Ianire, additional, Alende Castro, Vanessa, additional, Brea Aparicio, Ruth, additional, Vega Molpeceres, Sonia, additional, Pons Viñas, Estel, additional, del Río Pérez, Oscar, additional, Valero Rovira, Silvia, additional, Villar-García, Judit, additional, Gómez-Junyent, Joan, additional, Knobel, Hernando, additional, Cánepa, María Cecilia, additional, Castañeda Espinosa, Silvia, additional, Sorli Redò, Luisa, additional, Güerri-Fernández, Roberto, additional, Milagro Montero, María, additional, Horcajada, Juan Pablo, additional, García Vázquez, Elisa, additional, Moral Escudero, Encarnación, additional, Hernández Torres, Alicia, additional, García Almodóvar, Esther, additional, Sáez Barberá, Carmen, additional, Karroud, Zineb, additional, Hernández Quero, José, additional, Vinuesa García, David, additional, García Fogeda, José Luis, additional, Peregrina, José Antonio, additional, Novella Mena, María, additional, Hernández Gutiérrez, Cristina, additional, Sanz Moreno, José, additional, Pérez Tanoira, Ramón, additional, Sierra Rodríguez, Rodrigo, additional, Alonso Menchén, David, additional, Gutiérrez García, Aida, additional, Arranz Caso, Alberto, additional, Cuadros González, Juan, additional, Álvarez de Mon Soto, Melchor, additional, Díaz de Brito Fernández, Vicente Ferrer, additional, Sanmarti Vilamala, Montserrat, additional, Gabarrell Pascuet, Aina, additional, Molina Morant, Daniel, additional, España Cueto, Sergio, additional, Cámara Fernández, Jonathan, additional, Sabater Gil, Albert, additional, Muñoz López, Laura, additional, Sáez Escolano, Paula, additional, Bejarano Tello, Esperanza, additional, Sempere Alcocer, Marco Antonio, additional, Álvarez Martin, Salvador, additional, De los Santos Gil, Ignacio, additional, García-Fraile, Lucio, additional, Sampedro Núñez, Miguel, additional, Barrios Blandino, Ana, additional, Rodríguez Franco, Carlos, additional, Useros Brañas, Daniel, additional, Villa Martí, Almudena, additional, Oliver Ortega, Javier, additional, Costanza Espiño Álvarez, Alexia, additional, Sanz Sanz, Jesús, additional, Rexach Fumaña, María, additional, Abascal Cambras, Ivette, additional, Pérez Jaén, Ana del Cielo, additional, Sala Jofre, Clara, additional, Casas Rodríguez, Susana, additional, Tortajada Alamilla, Cecilia, additional, Oltra, Carmina, additional, Masiá Canuto, Mar, additional, Gutiérrez Rodero, Félix, additional, Ferrer Ribera, Ana, additional, Bea Serrano, Carlos, additional, Pedromingo Kus, Miguel, additional, Garcinuño, María Ángeles, additional, Fiorante, Silvana, additional, Pérez Pinto, Sergio, additional, Hernández Machín, Pilar, additional, Alastrué Violeta, Alba, additional, Fariñas Álvarez, María Carmen, additional, González Rico, Claudia, additional, Arnaiz de las Revillas, Francisco, additional, Calvo, Jorge, additional, Gozalo, Mónica, additional, Mora Gómez, Francisco, additional, Milagro Beamonte, Ana, additional, Latorre-Millán, Miriam, additional, Rezusta López, Antonio, additional, Martínez Sapiña, Ana, additional, Meije, Yolanda, additional, Duarte Borges, Alejandra, additional, Pareja Coca, Julia, additional, Clemente Presas, Mercedes, additional, Losa García, Juan Emilio, additional, Vegas Serrano, Ana, additional, Pérez-Rodríguez, M. Teresa, additional, Pérez González, Alexandre, additional, Belhassen-García, Moncef, additional, Rodríguez-Alonso, Beatriz, additional, López-Bernus, Amparo, additional, Carbonell, Cristina, additional, Torres Perea, Rafael, additional, Cantón de Seoane, Juan, additional, Alonso, Blanca, additional, Kamal, Sara Lidia, additional, Cajuela, Lucia, additional, Roa, David, additional, Cervero, Miguel, additional, Oreja, Alberto, additional, Avilés, Juan Pablo, additional, Martín, Lidia, additional, Pelegrín Senent, Iván, additional, Rouco Esteves Marques, Rosana, additional, Parra Ruiz, Jorge, additional, Ramos Sesma, Violeta, additional, Abadia Otero, Jessica, additional, Salillas Hernando, Juan, additional, Torres Sánchez del Arco, Robert, additional, Torralba González de Suso, Miguel, additional, Serrano Martínez, Alberto, additional, Gilaberte Reyzábal, Sergio, additional, Pacheco Martínez-Atienza, Marina, additional, Liébana Gómez, Mónica, additional, Fernández Rodríguez, Sara, additional, Varela Plaza, Álvaro, additional, Calvo Sánchez, Henar, additional, Martínez Martín, Patricia, additional, González- Ruano, Patricia, additional, Malmierca Corral, Eduardo, additional, Rábago Lorite, Isabel, additional, Pérez-Monte Mínguez, Beatriz, additional, García Flores, Ángeles, additional, Comas Casanova, Pere, additional, Sirisi, Merce, additional, Rojas, Richard, additional, Díaz de Tuesta del Arco, José Luis, additional, Figueroa Cerón, Ruth, additional, González Sarria, Ander, additional, Alemán Valls, Remedios, additional, Alonso Socas, María del Mar, additional, Sanz Peláez, Oscar, additional, Mohamed Ramírez, Karim, additional, Riera Jaume, Melchor, additional, Vilchez, Helem Haydee, additional, Albertí, Francesc, additional, Cañabate, Ana Isabel, additional, Moreno Cuerda, Víctor J., additional, Álvarez Kaelis, Silvia, additional, Álvarez Zapatero, Beatriz, additional, García García, Alejandro, additional, Isaba Ares, Elena, additional, Morcate Fernández, Covadonga, additional, Pérez Rodríguez, Andrea, additional, Ramos Merino, Lucía, additional, Castelo Corral, Laura, additional, Rodríguez Mahía, María, additional, González Bardanca, Mónica, additional, Sánchez Vidal, Efrén, additional, Míguez Rey, Enrique, additional, De la Torre Lima, Javier, additional, García de Lomas Guerrero, José Mª, additional, Morte, Elena, additional, Loscos, Silvia, additional, Camón, Ana, additional, Gómez García, Lucía, additional, Boix Palop, Lucia, additional, Dietl Gómez-Luengo, Beatriz, additional, Pedrola Gorrea, Iris, additional, Blasco Claramunt, Amparo, additional, López Mestanza, Cristina, additional, Fraile Villarejo, Esther, additional, Tosco Núñez, Tomás, additional, Aroca Ferri, María, additional, Algado Rabasa, José Tomas, additional, Garijo Saiz, Ana María, additional, Amador Prous, Concepción, additional, Baño, Jesús Rodriguez, additional, Retamar, Pilar, additional, Valiente, Adoración, additional, López-Cortés, Luis E., additional, Sojo, 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Villalba, Eva Pilar, additional, Jiménez Martínez, Isabel, additional, Estrada Fernández, Guillermo, additional, Lorén Vargas, María, additional, Parra Arribas, Nuria, additional, Martínez Cilleros, Carmen, additional, Villasante de la Puente, Aránzazu, additional, García Delange, Teresa, additional, Ruiz Rodríguez, María José, additional, Robledo del Prado, Marta, additional, Abad Almendro, Juan Carlos, additional, Muñoz del Rey, José Román, additional, Jiménez Álvaro, Montaña, additional, Coy Coy, Javier, additional, Poquet Catala, Inmaculada, additional, Santos Peña, Marta, additional, Naranjo Velasco, Virginia, additional, Manso Gómez, Tamara, additional, Quilez Ágreda, Delia, additional, Barbeito Castiñeiras, Gema, additional, Domínguez Santalla, María Jesús, additional, Mao Martín, Laura, additional, Alonso Navarro, Rodrigo, additional, Ampuero Martinich, Jose David, additional, Barrós González, Raquel, additional, Galindo Martín, María Aránzazu, additional, Herrera Pacheco, Lourdes, additional, Martínez Avilés, Rocío, additional, Rodrigo González, Sara, additional, Rodríguez Leal, Cristóbal Manuel, additional, Romay Lema, Eva María, additional, Suárez Gil, Roi, additional, Ibarguren Pinilla, Maialen, additional, Marimón Ortiz de Zárate, José María, additional, Vidaur Tello, Loreto, additional, Kortajarena Urkola, Xabier, additional, García Gómez, Miriam, additional, Aranguren Arostegui, Asier, additional, Álvarez de Castro, Maria, additional, Martínez Mateu, Cintia María, additional, Rodríguez Gómez, Francisco, additional, Muñoz Beamud, Francisco, additional, Chamarro Martí, Elena, additional, Cardona Rivera, Merce, additional, Zakariya-Yousef Breval, Ismail, additional, Rico Rodríguez, Marta, additional, Llenas García, Jara, additional, Sánchez Arenas, Mª Carmen, additional, Fernández Cruz, Ana, additional, Calderón Parra, Jorge, additional, López Dosil, Marcos, additional, Ramos Martínez, Antonio, additional, Múñez Rubio, Elena, additional, Callejas Díaz, Alejandro, additional, Vázquez Comendador, José Manuel, additional, Diego Yagüe, Itziar, additional, Expósito Palomo, Esther, additional, Anel Pedroche, Jorge, additional, Álvarez Franco, Raquel, additional, Fernández de Orueta, Lucía, additional, Vates Gómez, Roberto, additional, Cardona Arias, Andrés Felipe, additional, Marguenda Contreras, Pablo, additional, Gaspar Alonso-Vega, Gabriel, additional, Aranda Rife, Elena María, additional, Martínez Cifre, Blanca, additional, Roger Zapata, Daniel, additional, Martín Rubio, Irene, additional, Barbosa Ventura, André, additional, Piñero, Iván, additional, Bahamonde Carrasco, Alberto, additional, Runza Buznego, Paula, additional, Talavera García, Eva, additional, Lamata Subero, Marta, additional, Urrutia Losada, Ainhoa, additional, Arteche Eguizabal, Lorea, additional, Delgado Sánchez, Elisabet, additional, Molina Peinado, Virginia, additional, Caro Bragado, Sarah, additional, Domínguez de Pablos, Gema, additional, Roldán Fontana, Carolina, additional, Herrero Rodríguez, Carmen, additional, Force Sanmartín, Luis, additional, Aranega, Raquel, additional, Mera Fidalgo, Arantzazu, additional, Toda Savall, María Roca, additional, Merchante Gutiérrez, Nicolas, additional, León Jiménez, Eva María, additional, Del Pozo, José Luís, additional, Serralta Buades, Josefa, additional, Cabrera Tejada, Ginger Giorgiana, additional, Fernández-Ruiz, Mario, additional, Aguado, José María, additional, Maestro de la Calle, Guillermo, additional, Cisneros, José Miguel, additional, Aguilar-Guisado, Manuela, additional, Aldabó, Teresa, additional, Avilés, María Dolores, additional, Bueno, Claudio, additional, Cordero-Matía, Elisa, additional, Escoresca, Ana, additional, Gálvez-Benítez, Lydia, additional, Infante, Carmen, additional, Martín, Guillermo, additional, Praena, Julia, additional, Roca, Cristina, additional, Salamanca, Celia, additional, Suárez-Benjumea, Alejandro, additional, Vizcarra, Pilar, additional, Quereda, Carmen, additional, Rodriguez Dominguez, Mario José, additional, Gioia, Francesca, additional, Norman, Francesca, additional, Del Campo, Santos, additional, Cantón Moreno, Rafael, additional, Oteo Revuelta José, Antonio, additional, Santibáñez Sáenz, Paula, additional, Cervera Acedo, Cristina, additional, Ruiz Martínez, Carlos, additional, Blanco Ramos, José R., additional, Azcona Gutiérrez, José M., additional, García García, Concepción, additional, Alba Fernández, Jorge, additional, Ibarra Cucalón, Valvanera, additional, San Franco, Mercedes, additional, Metola Sacristán, Luis, additional, Meijide Míguez, Héctor, additional, Paulos Viñas, Silvia, additional, Menéndez, Justo, additional, Villares Fernández, Paula, additional, Montes Andújar, Lara, additional, Navarro Batet, Álvaro, additional, Ferrer Santolaria, Anna, additional, Padilla Salazar, María de la Luz, additional, Abella Vázquez, Lucy, additional, Hayek Peraza, Marcelino, additional, García Pardo, Antonio, additional, Hernández Carballo, Carolina, additional, Ruiz Fernández, Andrés Javier, additional, Barrio López, Isabel, additional, Martakoush, Alí, additional, Rojas-Vieyra, Agustín, additional, García Calvo, Sonia, additional, Villarreal García-Lomas, Mercedes, additional, Vizcaíno Callejón, Marta, additional, García García, María Pilar, additional, Lérida Urteaga, Ana, additional, Carrasco Fons, Natalia, additional, María Sanjuan, Beatriz, additional, Martín González, Lydia, additional, Sanz Zamudio, Camilo, additional, Alejos, Belén, additional, Moreno, Cristina, additional, Rava, Marta, additional, Iniesta, Carlos, additional, Izquierdo, Rebeca, additional, Suárez-García, Inés, additional, Díaz, Asunción, additional, Ruiz-Alguero, Marta, additional, and Hernando, Victoria, additional
Published: 2020
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18. Early antibiotic de-escalation in patients with severe infections due to bloodstream infection by enterobacterales: A post hoc analysis of a prospective multicentre cohort.

Author: Escrihuela-Vidal, Francesc, Palacios-Baena, Zaira R., Agirre, Josune Goikoetxea, Pérez-Rodríguez, María Teresa, Reguera Iglesias, José María, Cuquet Pedragosa, Jordi, Sánchez Gómez, Leticia, Boix-Palop, Lucía, Bahamonde Carrasco, Alberto, Natera-Kindelán, Clara, Fernández-Suárez, Jonathan, Jover-Sáenz, Alfredo, Smithson Amat, Alejandro, del Arco Jiménez, Alfonso, Sánchez Calvo, Juan Manuel, Martín-Aspas, Andrés, Martínez Pérez-Crespo, Pedro María, López-Hernández, Inmaculada, Rodríguez-Baño, Jesús, and López-Cortés, Luis Eduardo
Subjects: *CENTRAL venous catheters, *BILIARY tract, *URINARY organs, *BACTEREMIA, *ODDS ratio
Abstract: • Data on antibiotic de-escalation in sepsis associated with bloodstream infection caused by Enterobacterales are scarce. • Neutropenia, central catheter use, and extended-spectrum β-lactamase were negatively associated with de-escalation in sepsis. • De-escalation was not associated with mortality in patients with sepsis and bloodstream infection. Data about antibiotic de-escalation in sepsis associated with the bloodstream and caused by Enterobacterales are scarce. The objectives of this study are to identify factors associated with early de-escalation and to analyse the impact of de-escalation on mortality in patients with Enterobacterales bloodstream infection (BSI) with a Sequential Organ Failure Assessment (SOFA) score ≥ 2. A prospective, multicentre cohort study was performed including episodes of BSI due to Enterobacterales and a SOFA score ≥ 2 who were receiving an active antipseudomonal β-lactam; the isolate should be susceptible to at least 1 narrower-spectrum antibiotic. Variables associated with de-escalation were identified using logistic binary regression. The association of de-escalation with 30-day mortality was investigated. Confounding was controlled by calculating a propensity score used as covariate, as matching variable, and for inverse probability treatment weighting. Of the 582 patients included, de-escalation was performed in 311 (53.4%). Neutropenia (adjusted odds ratio [aOR] = 0.37; 95% confidence interval [95% CI] = 0.18–0.75), central venous catheter (aOR = 0.52; 95% CI = 0.32–0.83), and extended-spectrum β-lactamase (ESBL)–producing isolate (aOR = 0.28; 95% CI = 0.17–0.48) were negatively associated with de-escalation, and urinary tract source was positively associated (aOR = 2.27; 95% CI = 1.56–3.33). The 30-day mortality was 6.8% (21 patients) in de-escalated patients and 14.4% (39) in not de-escalated patients (relative risk, 0.63; 95% CI = 0.44–0.89). In multivariate analysis including the propensity score, de-escalation was not associated with mortality (AOR = 0.98; 95% CI = 0.39–2.47) and was protective in the case of urinary or biliary tract source (AOR = 0.31, 95% CI = 0.09–1.06). Matched and inverse probability treatment weighting analysis showed similar results. These results suggest that early de-escalation from antipseudomonal β-lactams is safe in patients with Enterobacterales bacteremia and SOFA ≥ 2. [Display omitted] [ABSTRACT FROM AUTHOR]
Published: 2024
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19. A comprehensive, predictive mortality score for patients with bloodstream infections (PROBAC): a prospective, multicentre cohort study.

Author: De la Rosa-Riestra S, López-Hernández I, Pérez-Rodríguez MT, Sousa A, Goikoetxea Agirre J, Reguera Iglesias JM, León E, Armiñanzas Castillo C, Sánchez Gómez L, Fernández-Natal I, Fernández-Suárez J, Boix-Palop L, Cuquet Pedragosa J, Jover-Sáenz A, Sánchez Calvo JM, Martín-Aspas A, Natera-Kindelán C, Del Arco Jiménez A, Bahamonde Carrasco A, Amat AS, Vinuesa García D, Martínez Pérez-Crespo PM, López-Cortés LE, and Rodríguez-Baño J
Subjects: Humans, Prospective Studies, Male, Female, Aged, Middle Aged, Spain epidemiology, Aged, 80 and over, Adult, Risk Factors, Prognosis, Logistic Models, Bacteremia mortality, Bacteremia microbiology
Abstract: Objectives: Bloodstream infections (BSI) are an important cause of mortality, although they show heterogeneity depending on patients and aetiological factors. Comprehensive and specific mortality scores for BSI are scarce. The objective of this study was to develop a mortality predictive score in BSI based on a multicentre prospective cohort., Methods: A prospective cohort including consecutive adults with bacteraemia recruited between October 2016 and March 2017 in 26 Spanish hospitals was randomly divided into a derivation cohort (DC) and a validation cohort (VC). The outcome was all-cause 30-day mortality. Predictors were assessed the day of blood culture growth. A logistic regression model and score were developed in the DC for mortality predictors; the model was applied to the VC., Results: Overall, 4102 patients formed the DC and 2009 the VC. Mortality was 11.8% in the DC and 12.34% in the CV; the patients and aetiological features were similar for both cohorts. The mortality predictors selected in the final multivariate model in the DC were age, cancer, liver cirrhosis, fatal McCabe underlying condition, polymicrobial bacteraemia, high-risk aetiologies, high-risk source of infection, recent use of broad-spectrum antibiotics, stupor or coma, mean blood pressure <70 mmHg and PaO2/FiO2 ≤ 300 or equivalent. Mortality in the DC was <2% for ≤2 points, 6%-14% for 3-7 points, 26%-45% for 8-12 points and ≥60% for ≥13 points. The predictive score had areas under the receiving operating curves of 0.81 (95% CI 0.79-0.83) in the DC and 0.80 (0.78-0.83) in the VC., Conclusions: A 30 day mortality predictive score in BSI with good discrimination ability was developed and internally validated., (© The Author(s) 2024. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Published: 2024
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20. Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project.

Author: Mussa M, Martínez Pérez-Crespo PM, Lopez-Cortes LE, Retamar-Gentil P, Sousa-Dominguez A, Goikoetxea-Aguirre AJ, Reguera-Iglesias JM, León Jiménez E, Fernández-Natal I, Armiñanzas-Castillo C, Boix-Palop L, Cuquet-Pedragosa J, Morán Rodríguez MÁ, Fernandez-Suarez J, Del Arco-Jiménez A, Jóver-Saenz A, Bahamonde-Carrasco A, Galan-Sanchez F, Sánchez-Calvo JM, Smithson-Amat A, Vinuesa-García D, Sánchez-Porto A, López-Hernández I, and Rodríguez-Baño J
Subjects: Aged, Anti-Bacterial Agents therapeutic use, Carbapenems, Cohort Studies, Enterococcus, Enterococcus faecalis, Humans, Risk Factors, Bacteremia drug therapy, Bacteremia epidemiology, Biliary Tract, Cholangiocarcinoma complications, Cholangitis complications, Enterococcus faecium, Gram-Positive Bacterial Infections drug therapy, Gram-Positive Bacterial Infections epidemiology, Renal Insufficiency, Chronic complications
Abstract: Biliary-tract bloodstream infections (BT-BSI) caused by Enterococcus faecalis and E. faecium are associated with inappropriate empirical treatment and worse outcomes compared to other etiologies. The objective of this study was to investigate the risk factors for enterococcal BT-BSI. Patients with BT-BSI from the PROBAC cohort, including consecutive patients with BSI in 26 Spanish hospitals between October 2016 and March 2017, were selected; episodes caused by E. faecalis or E. faecium and other causes were compared. Independent predictors for enterococci were identified by logistic regression, and a predictive score was developed. Eight hundred fifty episodes of BT-BSI were included; 73 (8.5%) were due to target Enterococcus spp. (48 [66%] were E. faecium and 25 [34%] E. faecalis). By multivariate analysis, the variables independently associated with Enterococcus spp. were (OR; 95% confidence interval): cholangiocarcinoma (4.48;1.32 to 15.25), hospital acquisition (3.58;2.11 to 6.07), use of carbapenems in the previous month (3.35;1.45 to 7.78), biliary prosthesis (2.19;1.24 to 3.90), and moderate or severe chronic kidney disease (1.55;1.07 to 2.26). The AUC of the model was 0.74 [95% CI0.67 to 0.80]. A score was developed, with 7, 6, 5, 4, and 2 points for these variables, respectively, with a negative predictive value of 95% for a score ≤ 6. A model, including cholangiocarcinoma, biliary prosthesis, hospital acquisition, previous carbapenems, and chronic kidney disease showed moderate prediction ability for enterococcal BT-BSI. Although the score will need to be validated, this information may be useful for deciding empirical therapy in biliary tract infections when bacteremia is suspected. IMPORTANCE Biliary tract infections are frequent, and a significant cause of morbidity and mortality. Bacteremia is common in these infections, particularly in the elderly and patients with cancer. Inappropriate empirical treatment has been associated with increased risk of mortality in bacteremic cholangitis, and the probability of receiving inactive empirical treatment is higher in episodes caused by enterococci. This is because many of the antimicrobial agents recommended in guidelines for biliary tract infections lack activity against these organisms. To the best of our knowledge, this is the first study analyzing the predictive factors for enterococcal BT-BSI and deriving a predictive score.
Published: 2022
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21. Pseudomonas aeruginosa Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development-Results from the PRO-BAC Cohort.

Author: Martínez Pérez-Crespo PM, Rojas Á, Lanz-García JF, Retamar-Gentil P, Reguera-Iglesias JM, Lima-Rodríguez O, Del Arco Jiménez A, Fernández Suárez J, Jover-Saenz A, Goikoetxea Aguirre J, León Jiménez E, Cantón-Bulnes ML, Ortega Lafont P, Armiñanzas Castillo C, Sevilla Blanco J, Cuquet Pedragosa J, Boix-Palop L, Becerril Carral B, Bahamonde-Carrasco A, Marrodan Ciordia T, Natera Kindelán C, Reche Molina IM, Herrero Rodríguez C, Pérez Camacho I, Vinuesa García D, Galán-Sánchez F, Smithson Amat A, Merino de Lucas E, Sánchez-Porto A, Guzmán García M, López-Hernández I, Rodríguez-Baño J, López-Cortés LE, and On Behalf Of The Probac Reipi/Geih-Seimc/Saei Group
Abstract: Community-onset bloodstream infections (CO-BSI) caused by gram-negative bacilli are common and associated with significant mortality; those caused by Pseudomonas aeruginosa are associated with worse prognosis and higher rates of inadequateempirical antibiotic treatment. The aims of this study were to describe the characteristics of patients with CO-BSI caused by P. aeruginosa, to identify predictors, and to develop a predictive score for P. aeruginosa CO-BSI. Materials/methods: PROBAC is a prospective cohort including patients >14 years with BSI from 26 Spanish hospitals between October 2016 and May 2017. Patients with monomicrobial P. aeruginosa CO-BSI and monomicrobial Enterobacterales CO-BSI were included. Variables of interest were collected. Independent predictors of Pseudomonas aeruginosa CO-BSI were identified by logistic regression and a prediction score was developed. Results: A total of 78patients with P. aeruginosa CO-BSI and 2572 with Enterobacterales CO-BSI were included. Patients with P. aeruginosa had a median age of 70 years (IQR 60−79), 68.8% were male, median Charlson score was 5 (IQR 3−7), and 30-daymortality was 18.5%. Multivariate analysis identified the following predictors of CO-BSI-PA [adjusted OR (95% CI)]: male gender [1.89 (1.14−3.12)], haematological malignancy [2.45 (1.20−4.99)], obstructive uropathy [2.86 (1.13−3.02)], source of infection other than urinary tract, biliary tract or intra-abdominal [6.69 (4.10−10.92)] and healthcare-associated BSI [1.85 (1.13−3.02)]. Anindex predictive of CO-BSI-PA was developed; scores ≥ 3.5 showed a negative predictive value of 89% and an area under the receiver operator curve (ROC) of 0.66. Conclusions: We did not find a good predictive score of P. aeruginosa CO-BSI due to its relatively low incidence in the overall population. Our model includes variables that are easy to collect in real clinical practice and could be useful to detect patients with very low risk of P. aeruginosa CO-BSI.
Published: 2022
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21 results on '"Bahamonde Carrasco, Alberto"'

1. Early antibiotic de-escalation in patients with severe infections due to bloodstream infection by enterobacterales: A post hoc analysis of a prospective multicentre cohort

2. Clinical characteristics, predisposing factors and outcomes for Enterococcus faecalis versus Enterococcus faecium bloodstream infections: a prospective multicentre cohort study.

3. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study

4. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

5. Does my patient really need this at admission? Seven opportunities for improving value in patient care during their hospitalization

6. Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study

7. Conventional Hospitalization versus Sequential Outpatient Parenteral Antibiotic Therapy for Staphylococcus aureus Bacteremia: Post-Hoc Analysis of a Multicenter Observational Cohort

8. Conventional Hospitalization versus Sequential Outpatient Parenteral Antibiotic Therapy for Staphylococcus aureus Bacteremia: Post-Hoc Analysis of a Multicenter Observational Cohort

9. Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project

10. Pseudomonas aeruginosa Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development—Results from the PRO-BAC Cohort

11. Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project

12. Mediterranean spotted fever with lymphangitis occurring from a tick bite lesion. A case in Spain

13. Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

14. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study

15. Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

16. Infections after spine instrumentation: effectiveness of short antibiotic treatment in a large multicentre cohort

17. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

18. Early antibiotic de-escalation in patients with severe infections due to bloodstream infection by enterobacterales: A post hoc analysis of a prospective multicentre cohort.

19. A comprehensive, predictive mortality score for patients with bloodstream infections (PROBAC): a prospective, multicentre cohort study.

20. Risk Factors and Predictive Score for Bacteremic Biliary Tract Infections Due to Enterococcus faecalis and Enterococcus faecium: a Multicenter Cohort Study from the PROBAC Project.

21. Pseudomonas aeruginosa Community-Onset Bloodstream Infections: Characterization, Diagnostic Predictors, and Predictive Score Development-Results from the PRO-BAC Cohort.

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