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224 results on '"Bahler, Clinton D."'

1. The association of quantitative PSMA PET parameters with pathologic ISUP grade: an international multicenter analysis

Author

Soeterik, Timo F. W., Heetman, Joris G., Hermsen, Rick, Wever, Lieke, Lavalaye, Jules, Vinken, Maarten, Bahler, Clinton D., Yong, Courtney, Tann, Mark, Kesch, Claudia, Seifert, Robert, Telli, Tugce, Chiu, Peter Ka-Fung, Wu, Kwan Kit, Zattoni, Fabio, Evangelista, Laura, Segalla, Emma, Barone, Antonio, Ceci, Francesco, Rajwa, Pawel, Marra, Giancarlo, Mazzone, Elio, Van Basten, Jean-Paul A., Van Melick, Harm H. E., Van den Bergh, Roderick C. N., and Gandaglia, Giorgio

Published
2024
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4. Comparing Magnetic Resonance Imaging and Prostate-Specific Membrane Antigen–Positron Emission Tomography for Prediction of Extraprostatic Extension of Prostate Cancer and Surgical Guidance: A Prospective Nonrandomized Clinical Trial

Author

Bahler, Clinton D., primary, Tachibana, Isamu, additional, Tann, Mark, additional, Collins, Katrina, additional, Swensson, Jordan K., additional, Green, Mark A., additional, Mathias, Carla J., additional, Tong, Yan, additional, Yong, Courtney, additional, Boris, Ronald S., additional, Brocken, Eric, additional, Hutchins, Gary D., additional, Sims, Justin B., additional, Hill, Danielle V., additional, Smith, Nathaniel, additional, Ferari, Christopher, additional, Love, Harrison, additional, and Koch, Michael O., additional

Published
2024
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9. Comparison of tracer kinetic models for 68Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients.

Author

Smith, Nathaniel J., Green, Mark A., Bahler, Clinton D., Tann, Mark, Territo, Wendy, Smith, Anne M., and Hutchins, Gary D.

Subjects
PROSTATE cancer patients, CANCER patients, LUTEINIZING hormone releasing hormone, POSITRON emission tomography, IMAGE analysis, GOODNESS-of-fit tests, CETUXIMAB
Abstract

Background: 68Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical uptake is generally evaluated in static images and quantified as standard uptake values (SUVs) for clinical decision-making. However, analysis of dynamic images characterizing both tracer uptake and pharmacokinetics may offer added insights into the underlying tissue pathophysiology. This study was undertaken to evaluate the suitability of various kinetic models for 68Ga-PSMA-11 PET analysis. Twenty-three lesions in 18 patients were included in a retrospective kinetic evaluation of 55-min dynamic 68Ga-PSMA-11 pre-prostatectomy PET scans from patients with biopsy-demonstrated intermediate- to high-risk prostate cancer. Three kinetic models—a reversible one-tissue compartment model, an irreversible two-tissue compartment model, and a reversible two-tissue compartment model, were evaluated for their goodness of fit to lesion and normal reference prostate time-activity curves. Kinetic parameters obtained through graphical analysis and tracer kinetic modeling techniques were compared for reference prostate tissue and lesion regions of interest. Results: Supported by goodness of fit and information loss criteria, the irreversible two-tissue compartment model optimally fit the time-activity curves. Lesions exhibited significant differences in kinetic rate constants (K1, k2, k3, Ki) and semiquantitative measures (SUV and %ID/kg) when compared with reference prostatic tissue. The two-tissue irreversible tracer kinetic model was consistently appropriate across prostatic zones. Conclusions: An irreversible tracer kinetic model is appropriate for dynamic analysis of 68Ga-PSMA-11 PET images. Kinetic parameters estimated by Patlak graphical analysis or full compartmental analysis can distinguish tumor from normal prostate tissue. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Assessing extra-prostatic extension for surgical guidance in prostate cancer: Comparing two PSMA-PET tracers with the standard-of-care

Author

Bahler, Clinton D., primary, Green, Mark A., additional, Tann, Mark A., additional, Swensson, Jordan K., additional, Collins, Katrina, additional, Alexoff, David, additional, Kung, Hank, additional, Brocken, Eric, additional, Mathias, Carla J., additional, Cheng, Liang, additional, Hutchins, Gary D., additional, and Koch, Michael O., additional

Published
2023
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34. Robotic and open partial nephrectomy for intermediate and high complexity tumors: a matched-pairs comparison of surgical outcomes at a single institution

Author

Abedali, Zain A., primary, Monn, M. Francesca, additional, Huddleston, Patrick, additional, Cleveland, Brent E., additional, Sulek, Jay, additional, Bahler, Clinton D., additional, Foster, Richard S., additional, Koch, Michael O., additional, Mellon, Matthew J., additional, Kaimakliotis, Hristos Z., additional, Cary, Clint, additional, Bihrle, Richard, additional, Gardner, Thomas A., additional, Masterson, Timothy A., additional, Boris, Ronald S., additional, and Sundaram, Chandru P., additional

Published
2020
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35. Robotic and open partial nephrectomy for tumors in a solitary kidney

Author

Abedali, Zain A, primary, Monn, M Francesca, additional, Cleveland, Brent E, additional, Sulek, Jay, additional, Bahler, Clinton D, additional, Koch, Michael O, additional, Bihrle, Richard, additional, Masterson, Timothy A, additional, Gardner, Thomas A, additional, Boris, Ronald S, additional, and Sundaram, Chandru P, additional

Published
2020
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39. [68Ga]Ga-P16-093 as a PSMA-Targeted PET Radiopharmaceutical for Detection of Cancer: Initial Evaluation and Comparison with [68Ga]Ga-PSMA-11 in Prostate Cancer Patients Presenting with Biochemical Recurrence

Author

Green, Mark A., primary, Hutchins, Gary D., additional, Bahler, Clinton D., additional, Tann, Mark, additional, Mathias, Carla J., additional, Territo, Wendy, additional, Sims, Justin, additional, Polson, Heather, additional, Alexoff, David, additional, Eckelman, William C., additional, Kung, Hank F., additional, and Fletcher, James W., additional

Published
2019
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41. [68Ga]Ga-P16-093 as a PSMA-Targeted PET Radiopharmaceutical for Detection of Cancer: Initial Evaluation and Comparison with [68Ga]Ga-PSMA-11 in Prostate Cancer Patients Presenting with Biochemical Recurrence.

Author

Green, Mark A., Hutchins, Gary D., Bahler, Clinton D., Tann, Mark, Mathias, Carla J., Territo, Wendy, Sims, Justin, Polson, Heather, Alexoff, David, Eckelman, William C., Kung, Hank F., and Fletcher, James W.

Subjects
PROSTATE cancer patients, EXOCRINE glands, RADIATION dosimetry, POSITRON emission tomography, PROSTATE-specific membrane antigen, IMAGE segmentation, RESEARCH, OLIGOPEPTIDES, RADIATION measurements, RESEARCH methodology, CANCER relapse, PROTEOLYTIC enzymes, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RADIOPHARMACEUTICALS, ETHYLENEDIAMINETETRAACETIC acid, PROSTATE tumors, ANTIGENS
Abstract

Purpose: This study was undertaken to evaluate radiation dosimetry for the prostate-specific membrane antigen targeted [68Ga]Ga-P16-093 radiopharmaceutical, and to initially assess agent performance in positron emission tomography (PET) detection of the site of disease in prostate cancer patients presenting with biochemical recurrence.Procedures: Under IND 133,222 and an IRB-approved research protocol, we evaluated the biodistribution and pharmacokinetics of [68Ga]Ga-P16-093 with serial PET imaging following intravenous administration to ten prostate cancer patients with biochemical recurrence. The recruited subjects were all patients in whom a recent [68Ga]Ga-PSMA-11 PET/X-ray computed tomography (CT) exam had been independently performed under IND 131,806 to assist in decision-making with regard to their clinical care. Voided urine was collected from each subject at ~ 60 min and ~ 140 min post-[68Ga]Ga-P16-093 injection and assayed for Ga-68 content. Following image segmentation to extract tissue time-activity curves and corresponding cumulated activity values, radiation dosimetry estimates were calculated using IDAC Dose 2.1. The prior [68Ga]Ga-PSMA-11 PET/CT exam (whole-body PET imaging at 60 min post-injection, performed with contrast-enhanced diagnostic CT) served as a reference scan for comparison to the [68Ga]Ga-P16-093 findings.Results: [68Ga]Ga-P16-093 PET images at 60 min post-injection provided diagnostic information that appeared equivalent to the subject's prior [68Ga]Ga-PSMA-11 scan. With both radiopharmaceuticals, sites of tumor recurrence were found in eight of the ten patients, identifying 16 lesions. The site of recurrence was not detected with either agent for the other two subjects. Bladder activity was consistently lower with [68Ga]Ga-P16-093 than [68Ga]Ga-PSMA-11. The kidneys, spleen, salivary glands, and liver receive the highest radiation exposure from [68Ga]Ga-P16-093, with estimated doses of 1.7 × 10-1, 6.7 × 10-2, 6.5 × 10-2, and 5.6 × 10-2 mGy/MBq, respectively. The corresponding effective dose from [68Ga]Ga-P16-093 is 2.3 × 10-2 mSv/MBq.Conclusions: [68Ga]Ga-P16-093 provided diagnostic information that appeared equivalent to [68Ga]Ga-PSMA-11 in this limited series of ten prostate cancer patients presenting with biochemical recurrence, with the kidneys found to be the critical organ. Diminished tracer appearance in the urine represents a potential advantage of [68Ga]Ga-P16-093 over [68Ga]Ga-PSMA-11 for detection of lesions in the pelvis. [ABSTRACT FROM AUTHOR]

Published
2020
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46. Preoperative Nomograms for Predicting Renal Function at 1 Year After Partial Nephrectomy

Author

Shum, Cheuk Fan, primary, Bahler, Clinton D., additional, Cary, Clint, additional, Masterson, Timothy A., additional, Boris, Ronald S., additional, Gardner, Thomas A., additional, Kaimakliotis, Hristos Z., additional, Foster, Richard S., additional, Bihrle, Richard, additional, Koch, Michael O., additional, Slaven, James E., additional, and Sundaram, Chandru P., additional

Published
2017
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50. Contributors

Author

Abdul-Muhsin, Haidar M., Ackerman, A. Lenore, Adams, Mark C., Ahmed, Hashim U., Alenezi, Husain, Anele, Uzoma A., Ark, Jacob T., Arlen, Angela M., Aron, Monish, Azhar, Raed A., Bagley, Demetrius H., Jr., Bahler, Clinton D., Barry, John M., Bass, Edward J., Bayne, Aaron P., Bella, Anthony J., Belsante, Michael, Bihrle, Richard, Billia, Michele, Blackburne, Andrew, Blute, Michael L., Sr., Borchert, Alex, Borofsky, Michael S., Brandes, Steven B., Brant, William O., Bream, Matthew, Brock, John W., III, Broderick, Gregory A., Broghammer, Joshua A., Brown, Elizabeth Timbrook, Brugh, Victor M., III, Buckley, Jill C., Burkhard, Fiona C., Burnett, Arthur L., Cabrera, Fernando, Cadeddu, Jeffrey A., Canvasser, Noah E., Caputo, Peter A., Carson, Culley C., III, Cartwright, Patrick C., Cary, Clint, Castle, Erik P., Cathcart, Paul, Challacombe, Ben, Chang, Sam S., Chapple, Christopher R., Cheng, Earl Y., Chew, Ben H., Chiles, Kelly A., Chin, Joseph L., Chopra, Sameer, Christie, Alison M., Chuang, Kai-wen, Chughtai, Bilal, Clark, Peter E., Clifton, Marisa, Cohn, Joshua A., Cone, Molly M., Cookson, Michael S., Copp, Hillary, Corbett, Sean T., Costabile, Raymond A., Cross, Brian W., Dalela, Deepansh, Danforth, Teresa L., Dechet, Christopher B., DeLong, Jessica M., Denstedt, John D., Desai, Mahesh R., Desai, Mihir M., Dinney, Colin P.N., Dmochowski, Roger R., Eastham, James A., Elliott, Sean P., Elmajian, Donald A., Emberton, Mark, Enemchukwu, Ekene A., Engel, Dena, Eswara, Jairam R., Faris, Sarah F., Ferrandino, Michael N., Fisch, Margit, Foster, Richard S., Frederick, Luke, Freilich, Drew A., Ganpule, Arvind P., Martin, Oscar Dario, Gaunay, Geoffrey Steven, Geiger, Timothy M., Gelpi, Francisco J., Ghani, Khurshid Ridwan, Ginsberg, David A., Glickman, Leonard, Goldfarb, David A., Goldman, Howard Brian, Goldstein, Marc, Gonzalgo, Mark L., Gregg, Justin R., Gupta, Shubham, Guralnick, Michael L., Gutierrez-Acevez, Jorge, Hadaway, Ashley N., Hamilton, Zachary A., Harriman, David I., Hatcher, David, Hausman, Jonathan, Hellstrom, Wayne J.G., Anthony Herndon, C.D., Herrell, S. Duke, Holzbeierlein, Jeffrey M., Hubosky, Scott G., Hudak, Steven J., Inman, Brant A., Inman, Richard D., Jarrett, Thomas W., Jordan, Gerald H., Kaimakliotis, Hristos Z., Kaouk, Jihad H., Kaplan, Steven A., Kaufman, Melissa R., Kavoussi, Louis R., Khurgin, Jacob L., Kim, Charles, Kirby, Roger S., Kirsch, Andrew J., Chang Kit, Laura, Knudsen, Bodo E., Kobashi, Kathleen C., Kovell, R. Caleb, Kraft, Kate, Krambeck, Amy E., Kraus, Stephen R., Krishnamurthi, Venkatesh, Krlin, Ryan M., Lacy, John, Landman, Jaime, Lay, Aaron H., Le, Ngoc-Bich (Nikki), Lee, Eugene W., Lingeman, James E., Lipkin, Michael E., Lloyd, L. Keith, Lue, Tom F., Marien, Tracy, Matlaga, Brian R., Mayer, Erik N., McAninch, Jack W., McClure, R. Dale, McVary, Kevin T., Milam, Douglas F., Milhouse, Olufenwa Famakinwa, Miller, Nicole L., Mirza, Moben, Mitchell, Marta Johnson, Morey, Allen F., Munver, Ravi, Myers, Jeremy B., Navai, Neema, Ng, Christopher S., Nitti, Victor W., O'Connor, R. Corey, Okeke, Zeph, O'Neil, Brock, Ordon, Michael, Packiam, Vignesh, Padmanabhan, Priya, Pak, Raymond W., Parekh, Dipen J., Patel, Abhishek P., Patel, Manish N., Patel, Sanjay, Pathak, Ram A., Peabody, James, Pearle, Margaret S., Penson, David F., Peterson, Andrew C., Polascik, Thomas J., Ponsky, Lee, Pope, John C., IV, Pow-Sang, Julio M., Rampersaud, Edward N., Rapp, David E., Raz, Shlomo, Reed-Maldonado, Amanda B., Reynolds, W. Stuart, Richstone, Lee, Rosenblum, Nirit, Routh, Jonathan C., Rovner, Eric S., Roy, Ornob, Sagalovich, Daniel, Sampaio, Francisco J.B., Scarpato, Kristen R., Schlegel, Peter N., Semerjian, Alice, Semins, Michelle Jo, Shalhav, Arieh, Sharma, Pranav, Siddiqui, Khurram Mutahir, Siegel, Steven W., Skoog, Steven J., Smith, Arthur D., Smith, Joseph A., Jr., Smith, Ryan P., Sood, Akshay, Sotelo, Rene, Spaliviero, Massimiliano, Stone, Nelson N., Stratton, Kelly L., Stricker, Phillip D., Studer, Urs E., Sturm, Renea M., Sundaram, Chandru P., Symons, James L.P., Tanrikut, Cigdem, Jack Tay, Kae, Terlecki, Ryan P., Thomas, John C., Thrasher, J. Brantley, Thüroff, Joachim W., Timberlake, Matthew D., Troche, Nelson Ramirez, Turek, Paul J., Vasavada, Sandip P., Wan, Julian, Wessells, Hunter, Wiener, John S., Wilson, Tracey Small, Winters, Jack Christian, Wolf, J. Stuart, Jr., Wolff, Gillian F., Wolter, Christopher E., Woods, Michael E., Yerkes, Elizabeth B., Zargar-Shoshtari, Kamran, Zee, Rebecca S., Zeltser, Ilia S., and Zhao, Philip T.

Published
2019
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