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26 results on '"Bai, Yu-Bin"'

1. The crystal structure of 4′-chloro-griseofulvin: (2S,6′R)-4′,7-dichloro-4,6-dimethoxy-6′-methyl-3H-spiro[benzofuran-2,1′-cyclohexan]-3′-ene-2′,3-dione, C16H14Cl2O5

Author

Yang Kai-Ming, Zhang Meng, Li Yi-Xiang, Huang Liang-Zhu, Zhao Yu, Yang Hua, and Bai Yu-Bin

Subjects
2211418, Physics, QC1-999, Crystallography, QD901-999
Abstract

C16H14Cl2O5, orthorhombic, P212121 (no. 19), a = 8.6429 (4) Å, b = 11.3361 (6) Å, c = 33.9029 (11) Å, V = 3321.7 (3) Å3, Z = 8, R gt(F) = 0.0635, wR ref(F 2) = 0.1630, T = 293(2) K.

Published
2024
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4. Au-Catalyzed Intermolecular [2+2] Cycloadditions between Chloroalkynes and Unactivated Alkenes

Author

Bai, Yu-Bin, Luo, Zaigang, Wang, Yuguang, Gao, Jin-Ming, and Zhang, Liming

Subjects
Chemical Sciences, General Chemistry
Abstract

The [2+2] cycloaddition is a versatile strategy for the synthesis of strained cyclobutenes of high synthetic value. In this study, two efficient intermolecular [2+2] cycloadditions between two different types of chloroalkynes and unactivated alkene are realized with gold catalysis. Of significance is that the reaction works with challenging monosubstituted unactivated alkenes, which is unprecedented in gold catalysis and scarcely documented in other metal-catalyzed/promoted reactions; moreover, the reaction exhibits excellent regioselectivities, which are much better than those reported in literature. With 1,2-disubstituted unactivated alkenes, the reaction is largely stereospecific. The cyclobutene products can be prepared in nearly gram scale and readily undergo further reactions including various cross-coupling reactions using the C(sp2)-Cl and/or C(sp2)-SPh bond, which in turn substantially broaden the scope of accessible cyclobutenes and enhance the synthetic utility of this bimolecular reaction.

Published
2018

5. The crystal structure of 4′-chloro-griseofulvin: (2S,6′R)-4′,7-dichloro-4,6-dimethoxy-6′-methyl-3H-spiro[benzofuran-2,1′-cyclohexan]-3′-ene-2′,3-dione, C16H14Cl2O5.

Author

Yang, Kai-Ming, Zhang, Meng, Li, Yi-Xiang, Huang, Liang-Zhu, Zhao, Yu, Yang, Hua, and Bai, Yu-Bin

Subjects
CRYSTAL structure, OSMIUM
Abstract

C16H14Cl2O5, orthorhombic, P212121 (no. 19), a = 8.6429 (4) Å, b = 11.3361 (6) Å, c = 33.9029 (11) Å, V = 3321.7 (3) Å3, Z = 8, Rgt(F) = 0.0635, wRref(F2) = 0.1630, T = 293(2) K. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Effect of Tangxinkang on Alox-12mRNA Gene Expression for Diabetes-Induced Cardiomyopathy

Author

Lin Zheng, Liu Cheng-gang, Bai Yu-bin, Zhou Xueming, Jiang De-you, Liu Chun-hong, Xie Ying, Wang Jun-xia, Wang Shu-hui, Wang Bing, Jang Zheng-long, Zhang Hai-li, Yao Li, and Fetherston Raul

Subjects
medicine.medical_specialty, Messenger RNA, Cardiomyopathy, Biology, medicine.disease, Gene expression profiling, Endocrinology, ALOX12, Internal medicine, Diabetes mellitus, Diabetic cardiomyopathy, Gene expression, medicine, Gene
Abstract

This study aimed to observe the therapeutical effect of a complex prescription of Tangxinkang on DC rats. The model rats, male Wistar rats, were established with multiple injections of low dose STZ and high calorie diet. Various kinds of examination methods were applied, including Affymetrix Co. US. Rat 2302.0 gene expression profiling chip and cluster analysis, to observe the effect of Tangxinkang on indicators. Then RT-PCR was applied for confirmatory experiment. Alox12 mRNA gene was one of the diabetic cardiomyopathy tissue differential expressions. The Alox12 mRNA genes were up-regulators in the DC model group and down-regulators in the Tangxinkang treatment group. The Alox12 mRNA was associated with diabetic cardiac muscle damage, and Tangxinkang had benign effect on Alox12 gene expression.

Published
2008

20. Antifungal Activity of Griseofulvin Derivatives against Phytopathogenic Fungi in Vitroand in Vivoand Three-Dimensional Quantitative Structure–Activity Relationship Analysis

Author

Bai, Yu-Bin, Gao, Yu-Qi, Nie, Xiao-Di, Tuong, Thi-Mai-Luong, Li, Ding, and Gao, Jin-Ming

Abstract

With environmental pollution, residual hazards accumulate and severe drug resistance and many other problems appear; some highly toxic drugs have been banned, and antifungal agents are far from satisfactory. Natural products play an important role in the discovery and development of new pesticides. The natural product griseofulvin (1) has been known as an antifungal agent in the treatment of dermatomycoses for decades. In this study, a series of new griseofulvin derivatives were synthesized with good yields. Their structures were characterized by 1H and 13C nuclear magnetic resonance and high-resolution mass spectrometry (electrospray ionization). The antifungal activities of griseofulvin analogues were first evaluated against five phytopathogenic fungi (Cytosporasp., Colletotrichum gloeosporioides, Botrytis cinerea, Alternaria solani, and Fusarium solani) in vitro. Of significance is that most of them showed excellent antifungal activities against C. gloeosporioides. The antifungal activities of the four best compounds (6a, 6c, 6e, and 6f) against C. gloeosporioideswere further investigated in vivousing infected apples. The results suggested that compounds 6c, 6e, and 6f[half-maximal inhibitory concentration (IC50) = 47.25 ± 1.46, 49.44 ± 1.50, and 53.63 ± 1.74 μg/mL, respectively] were better than thiophanate-methyl (IC50= 69.66 ± 6.07 μg/mL). Furthermore, comparative molecular field analysis was performed on the basis of the antifungal activity results of all 22 of the compounds against C. gloeosporioidesin vitro. The three-dimensional coefficient contour plots revealed that the suitable bulky and electronegative acyl-substituted groups seem to be more favorable for increasing activity at the 4′ position of griseofulvin. The structure–activity relationships were also discussed. Griseofulvin derivatives can be used for the development of highly effective and safe agricultural fungicides.

Published
2019
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24. Natural products as sources of new fungicides (II): antiphytopathogenic activity of 2,4-dihydroxyphenyl ethanone derivatives.

Author

Nandinsuren, Tseden, Shi, Wei, Zhang, An-Ling, Bai, Yu-Bin, and Gao, Jin-Ming

Abstract

A series of 17 simple 1-(2,4-dihydroxyphenyl) ethanones were synthesised, and their structures characterised by 1H, 13C NMR and ESI-MS. Their in vitro antifungal activities were evaluated against five phytopathogenic fungi including Glomerella cingulate, Botrytis cirerea, Fusarium graminearum, Curvularia lunata and Fusarium oxysporum f. sp. vasinfectum by the mycelial growth inhibition assay. Compounds 2g and 2h exhibited broad-spectrum inhibitory activity against the mycelial growth of the tested pathogens with IC50 values in the range of 16–36 μg/mL, and in particular being more active to G. cingulate, with IC50 values of 16.50 and 19.25 μg/mL, respectively, than the other pathogens. Preliminary SAR indicated that an α,β-unsaturated ketone unit of the alkyl chain of the compounds is the structure requirement for fungicidal action. The results suggested that 2g and 2h may be promising leads in the development of new antifungal agents. [ABSTRACT FROM AUTHOR]

Published
2016
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26. The crystal structure of 4′-chloro-griseofulvin: (2S,6′R)-4′,7-dichloro-4,6-dimethoxy-6′-methyl-3H-spiro[benzofuran-2,1′-cyclohexan]-3′-ene-2′,3-dione, C16H14Cl2O5.

Author

Yang, Kai-Ming, Zhang, Meng, Li, Yi-Xiang, Huang, Liang-Zhu, Zhao, Yu, Yang, Hua, and Bai, Yu-Bin

Subjects
*CRYSTAL structure, *OSMIUM
Abstract

C16H14Cl2O5, orthorhombic, P212121 (no. 19), a = 8.6429 (4) Å, b = 11.3361 (6) Å, c = 33.9029 (11) Å, V = 3321.7 (3) Å3, Z = 8, Rgt(F) = 0.0635, wRref(F2) = 0.1630, T = 293(2) K. [ABSTRACT FROM AUTHOR]

Published
2024
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