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2. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schneider, Markus P., Schultheiss, Ulla T., Friedrich, Nele, and Nauck, Matthias

Published
2023
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3. Differential Prognostic Utility of Adiposity Measures in Chronic Kidney Disease

Author

Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Paul, Rainer, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Cejka, Vladimir, Störk, Stefan, Nadal, Jennifer, Sitter, Thomas, Meiselbach, Heike, Busch, Martin, Schneider, Markus P., Saritas, Turgay, Schultheiss, Ulla T., Kotsis, Fruzsina, Wanner, Christoph, Eckardt, Kai-Uwe, and Krane, Vera

Published
2023
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4. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Kraska, Detlef, Reis, André, Ekici, Arif B., Becker, Susanne, Alberth-Schmidt, Ulrike, Marschall, Sabine, Schefler, Eugenia, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Schmidt-Ott, Kai, Zeier, Martin, Sommerer, Claudia, Aykac, Mehtap, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Müller-Krebs, Sandra, Schultheiss, Ulla T., Friedrich, Nele, Nauck, Matthias, Nußhag, Christian, Reiser, Jochen, and Hayek, Salim S.

Published
2023
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8. Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort

Author

Winitzki, Doris, Zacharias, Helena U., Nadal, Jennifer, Baid-Agrawal, Seema, Schaeffner, Elke, Schmid, Matthias, Busch, Martin, Bergmann, Manuela M., Schultheiss, Ulla, Kotsis, Fruzsina, Stockmann, Helena, Meiselbach, Heike, Wolf, Gunter, Krane, Vera, Sommerer, Claudia, Eckardt, Kai-Uwe, Schneider, Markus P., Schlieper, Georg, Floege, Jürgen, and Saritas, Turgay

Published
2022
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10. Low adherence to CKD-specific dietary recommendations associates with impaired kidney function, dyslipidemia, and inflammation

Author

Kaesler, Nadine, Baid-Agrawal, Seema, Grams, Sabine, Nadal, Jennifer, Schmid, Matthias, Schneider, Markus P., and Eckardt, Kai-Uwe

Subjects
Chronic kidney failure -- Diet therapy -- Complications and side effects, Patient compliance -- Influence, Inflammation -- Risk factors, Dyslipidemias -- Risk factors, Food/cooking/nutrition, Health
Abstract

Background/Objectives A diet following chronic kidney disease (CKD)-specific recommendations is considered essential for optimal management of patients with CKD. However, data on the adherence to these recommendations and its implications for health-relevant biomarkers are lacking. The objectives were to estimate adherence to CKD-specific dietary recommendations, to identify characteristics and lifestyle variables associated with poor adherence, and to investigate the relationship of adherence with biomarkers. Methods In this cross-sectional analysis, average dietary intake was estimated in 3193 participants with moderately severe CKD enrolled into the observational multicenter German CKD study using a food frequency questionnaire. A CKD diet score was developed to assess adherence to CKD-specific dietary recommendations based on intake of sodium, potassium, fiber, protein, sugar, and cholesterol. The associations of dietary adherence with characteristics, lifestyle variables, and biomarker levels were determined. Results Logistic regression analysis revealed younger age, higher body mass index, male gender, lower educational attainment, various lifestyle variables (cigarette smoking, infrequent alcohol consumption, low physical activity), and lower estimated glomerular filtrate rate associated with lower adherence to dietary recommendations. Low adherence to dietary recommendations was further associated with dyslipidemia, higher uric acid, and C-reactive protein levels. Associations between low dietary adherence and biomarkers were mostly driven by low intake of fiber and potassium, and high intake of sugar and cholesterol. Conclusions This study revealed differential characteristics and biomarkers associated with lower adherence to CKD-specific dietary recommendations. Promotion of CKD-specific dietary recommendations may help to mitigate the adverse prognosis in CKD patients., Author(s): Nadine Kaesler [sup.1] , Seema Baid-Agrawal [sup.2] , Sabine Grams [sup.3] , Jennifer Nadal [sup.4] , Matthias Schmid [sup.4] , Markus P. Schneider [sup.5] [sup.6] , Kai-Uwe Eckardt [sup.5] [...]

Published
2021
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11. COVID-19 Outcomes and Vaccinations in Swedish Solid Organ Transplant Recipients 2020–2021: A Nationwide Multi-Register Comparative Cohort Study

Author

Søfteland, John Mackay, primary, Li, Huiqi, additional, Magnusson, Jesper M., additional, Leach, Susannah, additional, Friman, Vanda, additional, Gisslén, Magnus, additional, Felldin, Marie, additional, Schult, Andreas, additional, Karason, Kristjan, additional, Baid-Agrawal, Seema, additional, Wallquist, Carin, additional, and Nyberg, Fredrik, additional

Published
2024
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12. Prescription Practices in Patients With Mild to Moderate CKD in India

Author

Prasad, Narayan, Yadav, Ashok Kumar, Kundu, Monica, Sethi, Jasmin, Jaryal, Ajay, Sircar, Dipankar, Modi, Gopesh K., Kamboj, Kajal, Sahay, Manisha, Gopalakrishnan, Natarajan, Kaur, Prabhjot, Vikrant, Sanjay, Varughese, Santosh, Baid-Agrawal, Seema, Singh, Shivendra, Gang, Sishir, Parameswaran, Sreejith, Kumar, Vivek, Ghosh, Arpita, and Jha, Vivekanand

Published
2021
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13. Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schachtl-Riess, Johanna F., Kheirkhah, Azin, Grüneis, Rebecca, Di Maio, Silvia, Schoenherr, Sebastian, Streiter, Gertraud, Losso, Jamie Lee, Paulweber, Bernhard, Lamina, Claudia, and Coassin, Stefan

Published
2021
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14. Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus, Dienemann, Thomas, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Ganslandt, Thomas, Reis, André, Ekici, Arif B., Avendaño, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Zitzmann, Rita, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schlieper, Georg, Saritas, Turgay, Ernst, Sabine, Beaujean, Nicole, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Woitke, Rebecca, Wolf, Gunter, Busch, Martin, Fuß, Rainer, Sitter, Thomas, Blank, Claudia, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, Schmid, Matthias, Nadal, Jennifer, Fazzini, Federica, Lamina, Claudia, Schultheiss, Ulla T., and Steinbrenner, Inga

Published
2020
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15. Association Between Dietary Patterns and Kidney Function in Patients With Chronic Kidney Disease: A Cross-Sectional Analysis of the German Chronic Kidney Disease Study

Author

Heindel, Judith, Baid-Agrawal, Seema, Rebholz, Casey M., Nadal, Jennifer, Schmid, Matthias, Schaeffner, Elke, Schneider, Markus P., Meiselbach, Heike, Kaesler, Nadine, Bergmann, Manuela, Ernst, Sabine, Krane, Vera, Eckardt, Kai-Uwe, Floege, Jürgen, Schlieper, Georg, and Saritas, Turgay

Published
2020
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16. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Schneider, Markus P., primary, Schmid, Matthias, additional, Nadal, Jennifer, additional, Krane, Vera, additional, Saritas, Turgay, additional, Busch, Martin, additional, Schultheiss, Ulla T., additional, Meiselbach, Heike, additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Floege, Jürgen, additional, Kronenberg, Florian, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
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19. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Sommerer, Claudia, primary, Müller-Krebs, Sandra, additional, Nadal, Jennifer, additional, Schultheiss, Ulla T., additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Schmid, Matthias, additional, Nußhag, Christian, additional, Reiser, Jochen, additional, Eckardt, Kai-Uwe, additional, Zeier, Martin, additional, Hayek, Salim S., additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Kraska, Detlef, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Alberth-Schmidt, Ulrike, additional, Marschall, Sabine, additional, Schefler, Eugenia, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Schmidt-Ott, Kai, additional, Sommerer, Claudia, additional, Aykac, Mehtap, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
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22. Differential prognostic utility of adiposity measures in chronic kidney disease

Author

Cejka, Vladimir, primary, Störk, Stefan, additional, Nadal, Jennifer, additional, Schmid, Matthias, additional, Sommerer, Claudia, additional, Sitter, Thomas, additional, Meiselbach, Heike, additional, Busch, Martin, additional, Schneider, Markus P., additional, Saritas, Turgay, additional, Schultheiss, Ulla T., additional, Kotsis, Fruzsina, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Krane, Vera, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Zeier, Martin, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
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24. Renin-angiotensin blocker use is associated with improved cardiovascular mortality in Indian patients with mild-moderate chronic kidney disease—findings from the ICKD study

Author

Prasad, Narayan, primary, Yadav, Ashok Kumar, additional, Kundu, Monica, additional, Jaryal, Ajay, additional, Sircar, Dipankar, additional, Modi, Gopesh, additional, Sahay, Manisha, additional, Gopalakrishnan, Natarajan, additional, Vikrant, Sanjay, additional, Varughese, Santosh, additional, Baid-Agrawal, Seema, additional, Singh, Shivendra, additional, Gang, Sishir, additional, Parameswaran, Sreejith, additional, Ghosh, Arpita, additional, Kumar, Vivek, additional, and Jha, Vivekanand, additional

Published
2022
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26. Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study

Author

Schneider, Markus P., primary, Schmid, Matthias, additional, Nadal, Jennifer, additional, Wanner, Christoph, additional, Krane, Vera, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Busch, Martin, additional, Sitter, Thomas, additional, Friedrich, Nele, additional, Stockmann, Helena, additional, Meiselbach, Heike, additional, Nauck, Matthias, additional, Kronenberg, Florian, additional, Eckardt, Kai-Uwe, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2022
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27. Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls

Author

Søfteland, John M., primary, Gisslén, Magnus, additional, Liljeqvist, Jan-Åke, additional, Friman, Vanda, additional, de Coursey, Emily, additional, Karason, Kristjan, additional, Ekelund, Jan, additional, Felldin, Marie, additional, Magnusson, Jesper, additional, Baid-Agrawal, Seema, additional, Wallquist, Carin, additional, Schult, Andreas, additional, Jacobsson, Hanna, additional, Bergdahl, Anders, additional, Bemark, Mats, additional, Andersson, Lars-Magnus, additional, Holm Gunnarsson, Inger, additional, Stenström, Jan, additional, and Leach, Susannah, additional

Published
2022
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28. Multiparametric magnetic resonance imaging allows non-invasive functional and structural evaluation of diabetic kidney disease

Author

Makvandi, Kianoush, primary, Hockings, Paul D, additional, Jensen, Gert, additional, Unnerstall, Tim, additional, Leonhardt, Henrik, additional, Jarl, Lisa V, additional, Englund, Camilla, additional, Francis, Susan, additional, Sundgren, Anna K, additional, Hulthe, Johannes, additional, and Baid-Agrawal, Seema, additional

Published
2022
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30. Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study

Author

Steinbrenner, Inga, primary, Schultheiss, Ulla T., additional, Kotsis, Fruzsina, additional, Schlosser, Pascal, additional, Stockmann, Helena, additional, Mohney, Robert P., additional, Schmid, Matthias, additional, Oefner, Peter J., additional, Eckardt, Kai-Uwe, additional, Köttgen, Anna, additional, Sekula, Peggy, additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Schultheiß, Ulla T., additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, Gronwald, Wolfram, additional, and Nadal, Jennifer, additional

Published
2021
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31. Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease

Author

Schachtl-Riess, Johanna F., Kheirkhah, Azin, Grüneis, Rebecca, Di Maio, Silvia, Schoenherr, Sebastian, Streiter, Gertraud, Losso, Jamie Lee, Paulweber, Bernhard, Eckardt, Kai-Uwe, Köttgen, Anna, Lamina, Claudia, Kronenberg, Florian, Coassin, Stefan, For The GCKD Investigators, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter J., Gronwald, Wolfram, Schmid, Matthias, and Nadal, Jennifer

Subjects
medicine.medical_specialty, 610 Medizin, Coronary Artery Disease, Mendelian randomization, cardiovascular disease, cohort study, copy number variation, genetic variability, lipoprotein(a), Coronary artery disease, Kringles, Internal medicine, Medicine, Humans, Copy-number variation, Genetic variability, Prospective Studies, Risk factor, ddc:610, biology, business.industry, Genetic Variation, Lipoprotein(a), medicine.disease, biology.protein, Cardiology, lipids (amino acids, peptides, and proteins), biological phenomena, cell phenomena, and immunity, Cardiology and Cardiovascular Medicine, business, Lipoprotein, Cohort study
Abstract

Background: Lipoprotein(a) (Lp(a)) concentrations are a major independent risk factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up to 70% of the LPA coding sequence is located in the hypervariable kringle IV type 2 (KIV-2) region. It is hardly accessible by conventional technologies, but may contain functional variants. Objectives: This study sought to investigate the new, very frequent splicing variant KIV-2 4733G>A on Lp(a) and CAD. Methods: We genotyped 4733G>A in the GCKD (German Chronic Kidney Disease) study (n = 4,673) by allele-specific polymerase chain reaction, performed minigene assays, identified proxy single nucleotide polymorphisms and used them to characterize its effect on CAD by survival analysis in UK Biobank (n = 440,234). Frequencies in ethnic groups were assessed in the 1000 Genomes Project. Results: The 4733G>A variant (38.2% carrier frequency) was found in most isoform sizes. It reduces allelic expression without abolishing protein production, lowers Lp(a) by 13.6 mg/dL (95% CI: 12.5-14.7; P < 0.0001) and is the strongest variance-explaining factor after the smaller isoform. Splicing of minigenes was modified. Compound heterozygosity (4.6% of the population) for 4733G>A and 4925G>A, another KIV-2 splicing mutation, reduces Lp(a) by 31.8 mg/dL and most importantly narrows the interquartile range by 9-fold (from 42.1 to 4.6 mg/dL) when compared to the wild type. In UK Biobank 4733G>A alone and compound heterozygosity with 4925G>A reduced HR for CAD by 9% (95% CI: 7%-11%) and 12% (95% CI: 7%-16%) (both P < 0.001). Frequencies in ethnicities differ notably. Conclusions: Functional variants in the previously inaccessible LPA KIV-2 region cooperate in determining Lp(a) variance and CAD risk. Even a moderate but lifelong genetic Lp(a) reduction translates to a noticeable CAD risk reduction.

Published
2021

32. The Indian Chronic Kidney Disease (ICKD) study: baseline characteristics

Author

Kumar, Vivek, primary, Yadav, Ashok Kumar, additional, Sethi, Jasmine, additional, Ghosh, Arpita, additional, Sahay, Manisha, additional, Prasad, Narayan, additional, Varughese, Santosh, additional, Parameswaran, Sreejith, additional, Gopalakrishnan, Natarajan, additional, Kaur, Prabhjot, additional, Modi, Gopesh K, additional, Kamboj, Kajal, additional, Kundu, Monica, additional, Sood, Vivek, additional, Inamdar, Neeraj, additional, Jaryal, Ajay, additional, Vikrant, Sanjay, additional, Nayak, Saurabh, additional, Singh, Shivendra, additional, Gang, Sishir, additional, Baid-Agrawal, Seema, additional, and Jha, Vivekanand, additional

Published
2021
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33. Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: the German Chronic Kidney Disease (GCKD) study

Author

Jing, Jiaojiao, Kielstein, Jan T., Schultheiss, Ulla T., Sitter, Thomas, Titze, Stephanie I., Schaeffner, Elke S., McAdams-DeMarco, Mara, Kronenberg, Florian, Eckardt, Kai-Uwe, Köttgen, Anna, Eckardt, Kai-Uwe, Titze, Stephanie, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Reis, André, Ekici, Arif B., Gefeller, Olaf, Hilgers, Karl F., Hübner, Silvia, Avendaño, Susanne, Becker-Grosspitsch, Dinah, Hauck, Nina, Seuchter, Susanne A., Hausknecht, Birgit, Rittmeier, Marion, Weigel, Anke, Beck, Andreas, Ganslandt, Thomas, Knispel, Sabine, Dressel, Thomas, Malzer, Martina, Floege, Jürgen, Eitner, Frank, Schlieper, Georg, Findeisen, Katharina, Arweiler, Elfriede, Ernst, Sabine, Unger, Mario, Lipski, Stefan, Schaeffner, Elke, Baid-Agrawal, Seema, Petzold, Kerstin, Schindler, Ralf, Köttgen, Anna, Schultheiss, Ulla, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Walz, Gerd, Haller, Hermann, Lorenzen, Johan, Kielstein, Jan T., Otto, Petra, Sommerer, Claudia, Föllinger, Claudia, Zeier, Martin, Wolf, Gunter, Busch, Martin, Paul, Katharina, Dittrich, Lisett, Sitter, Thomas, Hilge, Robert, Blank, Claudia, Wanner, Christoph, Krane, Vera, Schmiedeke, Daniel, Toncar, Sebastian, Cavitt, Daniela, Schönowsky, Karina, Börner-Klein, Antje, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weiensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, and Schmid, Matthias

Published
2015
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34. Disease burden and risk profile in referred patients with moderate chronic kidney disease: composition of the German Chronic Kidney Disease (GCKD) cohort

Author

Titze, Stephanie, Schmid, Matthias, Köttgen, Anna, Busch, Martin, Floege, Jürgen, Wanner, Christoph, Kronenberg, Florian, Eckardt, Kai-Uwe, Eckardt, Kai-Uwe, Titze, Stephanie, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Ganslandt, Thomas, Gefeller, Olaf, Schmid, Matthias, Köster, Jan, Malzer, Martina, Schlieper, Georg, Eitner, Frank, Meisen, Sabine, Kehl, Katharina, Arweiler, Elfriede, Floege, Jürgen, Schaeffner, Elke, Baid-Agrawal, Seema, Schindler, Ralf, Titze, Stephanie, Hübner, Silvia, Dienemann, Thomas, Hilgers, Karl F., Eckardt, Kai-Uwe, Köttgen, Anna, Schulthei, Ulla, Walz, Gerd, Kielstein, Jan T., Lorenzen, Johan, Haller, Hermann, Sommerer, Claudia, Zeier, Martin, Busch, Martin, Paul, Katharina, Wolf, Gunter, Hilge, Robert, Sitter, Thomas, Krane, Vera, Schmiedeke, Daniel, Toncar, Sebastian, Wanner, Christoph, Ekici, Arif B., Reis, André, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Kollertits, Barbara, Raschenberger, Julia, Kronenberg, Florian, Gronwald, Wolfram, Zacharias, Helena, and Oefner, Peter

Published
2015
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35. Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals

Author

Fazzini, Federica, Lamina, Claudia, Meiselbach, Heike, Schönherr, Sebastian, Forer, Lukas, Weissensteiner, Hansi, Pramstaller, Peter P., Eckardt, Kai-Uwe, Hicks, Andrew A., Kronenberg, Florian, GCKD Investigators, Raftopoulou, Athina, Schneider, Markus, Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Kraska, Detlef, Reis, André, Ekici, Arif B., Becker, Susanne, Koller, Adriana, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Fuchsberger, Christian, Reinhard, Ursula, Flöge, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Pattaro, Cristian, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Del Greco, Fabiola M., Raschenberger, Julia, Kollerits, Barbara, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Döttelmayer, Patricia, Fendt, Liane, and Fritz, Josef

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Mitochondrial DNA, DNA Copy Number Variations, chronic kidney disease, diabetes, metabolic syndrome, mitochondrial DNA copy number, 610 Medizin, Type 2 diabetes, 030204 cardiovascular system & hematology, Mitochondrion, DNA, Mitochondrial, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Medicine, Prospective Studies, Triglycerides, Aged, Metabolic Syndrome, ddc:610, diabetes, business.industry, Original Articles, Middle Aged, medicine.disease, Obesity, mitochondrial DNA copy number, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Original Article, Female, Waist Circumference, Metabolic syndrome, business, Body mass index, chronic kidney disease, Kidney disease
Abstract

Journal of internal medicine 290(1), 190-202 (2021). doi:10.1111/joim.13242, Published by Wiley-Blackwell, Oxford [u.a.]

Published
2021

38. Status of periodontal health in German patients suffering from chronic kidney disease - data from the GCKD study

Author

Dannewitz, Bettina, Sommerer, Claudia, Stölzel, Peggy, Baid‐Agrawal, Seema, Nadal, Jennifer, Bärthlein, Barbara, Wanner, Christoph, Eckardt, Kai‐Uwe, Zeier, Martin, Schlagenhauf, Ulrich, Krane, Vera, Jockel‐Schneider, Yvonne, and GCKD Study Investigators

Subjects
ddc:610
Abstract

Aim: To assess the prevalence and severity of periodontitis in patients with moderate chronic kidney disease (CKD) and comparing the results with the self‐reported periodontitis awareness of the study subjects. Material and methods: The periodontal status of 270 patients with moderate CKD randomly selected from a cohort of 5,217 subjects participating in the prospective observational German Chronic Kidney Disease (GCKD) project was analysed by recording bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL). Furthermore, the awareness of the study subjects of their periodontal conditions was evaluated by a self‐reported questionnaire. Results: 24.4% of the CKD study patients showed no or only mild signs of periodontal disease, 47.6% displayed moderate and 27% severe periodontitis. Questionnaire data revealed that 62.3% of the study subjects with severe periodontitis were not aware of the presence of the disease, 44.4% denied having received any systematic periodontal therapy so far, although 50% of them indicated to visit their dentist regularly for professional tooth cleanings. Conclusion: While the clinical study data confirm an increased prevalence of periodontitis in CKD patients, their self‐reported awareness of periodontitis was low.

Published
2019

40. PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function

Author

Kheirkhah, Azin, Lamina, Claudia, Kollerits, Barbara, Schachtl-Riess, Johanna F., Schultheiss, Ulla T., Forer, Lukas, Sekula, Peggy, Kotsis, Fruzsina, Eckardt, Kai-Uwe, Kronenberg, Florian, Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, B?rthlein, Barbara, Beck, Andreas, Reis, Andr?, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, K?ttgen, Anna, Schulthei?, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, J?rgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, B?rner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Sch?nherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, and Nadal, Jennifer

Published
2022
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42. Contributors

Author

Alangaden, George J., primary, Aldape, Michael J., additional, Allardet-Servent, Jérôme, additional, Allen, Upton D., additional, Ammerlaan, Heidi S.M., additional, Angelakis, Emmanouil, additional, Artenstein, Andrew, additional, Asboe, David, additional, Asiedu, Kingsley B., additional, Atherton, John C., additional, Aw, Tar-Ching, additional, Baid-Agrawal, Seema, additional, Bailey, Robin, additional, Bandel, Christopher, additional, Barie, Philip S., additional, Barillo, David J., additional, Bart, Pierre-Alexandre, additional, Bayston, Roger, additional, Beard, C. Ben, additional, Beeching, Nick J., additional, Bégué, Rodolfo E., additional, Benhamou, Yves, additional, Benson, Constance A., additional, Berbari, Elie F., additional, Berendt, Anthony R., additional, Bhatta, Madhav P., additional, Bille, Jacques, additional, Bitnun, Ari, additional, Black, Finn T., additional, Blair, Iain, additional, Blanche, Stéphane, additional, Bleck, Thomas P., additional, Bleeker-Rovers, Chantal P., additional, Bleijenberg, Gijs, additional, Bloch, Karen C., additional, Bonten, Marc J.M., additional, Boucher, Charles A.B., additional, Bourayou, Rafik, additional, Bouza, Emilio S., additional, Bowie, William R., additional, Brause, Barry D., additional, Brisse, Sylvain, additional, Britton, Warwick, additional, Brook, Itzhak, additional, Brown, David W.G., additional, Brun-Buisson, Christian, additional, Brust, James C.M., additional, Bryant, Amy E., additional, Bryskier, André, additional, Buller, R. Mark L, additional, Bush, Karen, additional, Calandra, Thierry, additional, Cameron, D. William, additional, Caraël, Michel, additional, Carr, Michael J., additional, Casas, Inmaculada, additional, Chambers, Stephen T., additional, Chiller, Katarina G., additional, Chiller, Tom M., additional, Chiodini, Peter L., additional, Chopra, Ian, additional, Chu, Anthony C., additional, Chung, Kevin K., additional, Clark, Benjamin M., additional, Clumeck, Nathan, additional, Cockerell, Clay J., additional, Cohen, Jonathan, additional, Collinge, John, additional, Conlon, Christopher P., additional, Corey, G. Ralph, additional, Cross, Alan, additional, Cross, John H., additional, Currier, Judith, additional, Curtis, Carmel M., additional, Dallabetta, Gina, additional, Davidson, Robert N., additional, Davies, Jane, additional, Day, Jeremy, additional, Day, Nicholas P.J., additional, De Gascun, Cillian F., additional, de Wit, Stéphane, additional, Delmont, Jean, additional, Dennis, David T., additional, Diemert, David J., additional, Doganay, Mehmet, additional, Doherty, Tom, additional, Dolecek, Christiane, additional, Donati, Stéphane Y., additional, Dondorp, Arjen M., additional, Doudier, Barbara, additional, Drancourt, Michel, additional, Drekonja, Dimitri M., additional, Drew, Richard H., additional, Duker, Jay S., additional, Dummer, J. Stephen, additional, Edwards, Charles N., additional, Ekkelenkamp, Miquel B., additional, Enright, Mark C., additional, Epstein, Paul R., additional, Erard, Veronique, additional, Eziefula, Alice Chijioke, additional, Feinberg, Mark B., additional, Fenollar, Florence, additional, Fenwick, Alan, additional, Fernandez, Luis, additional, Fierer, Joshua, additional, Finch, Roger G., additional, Flexner, Charles W., additional, Fluit, Ad C., additional, Ford-Jones, Elizabeth Lee, additional, Fournier, Pierre-Edouard, additional, Fraser, Victoria, additional, French, Martyn A., additional, Friedland, Jon S., additional, Fritz, Joseph M., additional, Furuya, E. Yoko, additional, Gage, Kenneth L., additional, Garcia, Lynne S., additional, Gastañaduy, Arturo S., additional, Ghanem, Khalil G., additional, Giannella, Maddalena, additional, Glaser, Carol A., additional, Glesby, Marshall J., additional, Glover, Sarah, additional, Glupczynski, Youri, additional, Gnann, John W., additional, Goddard, Andrew F., additional, Goldstein, Ellie J.C., additional, González, Iveth J., additional, Gorbach, Sherwood L., additional, Gottstein, Bruno, additional, Gowda, Ravi, additional, Grabenstein, John D., additional, Grange, John M., additional, Green, Michael D., additional, Green, Stephen T., additional, Greenblatt, Danielle T., additional, Greenwood, Brian, additional, Gregson, Aric L., additional, Groll, Andreas H., additional, Gupta, Aditya K., additional, Gwee, Kok-Ann, additional, Hall, William, additional, Hammer, Scott M., additional, Handa, Sajeev, additional, Hanfelt-Goade, Diane, additional, Harari, Alexandre, additional, Harris, Marianne, additional, Hartman, Barry J., additional, Hay, Roderick J., additional, Henderson, David K., additional, Hensley, Lisa E., additional, Herbert, Luke, additional, Hill, David R., additional, Hills, Timothy J., additional, Hinze, John David, additional, Hirsch, Hans H., additional, Hirschel, Bernard, additional, Hoepelman, Andy I.M., additional, Holland, Steven M., additional, Horgan, Mary M., additional, Howe, Robin, additional, Hughes, James M., additional, Hull, Mark W., additional, Inderlied, Clark B., additional, Ison, Michael G., additional, Jenks, Peter J., additional, Johnson, James R., additional, Jones, Theodore, additional, Kanno, Mettassebia, additional, Kauffman, Carol, additional, Kelly, Patrick, additional, Kendler, Jason S., additional, Keynan, Yoav, additional, Khan, Ali S., additional, Kho, Grace T., additional, Kinghorn, George R., additional, Klapper, Paul E., additional, Kluytmans, Jan AJW, additional, Kok, Menno, additional, Koné-Paut, Isabelle, additional, Krieger, John N., additional, Kroes, Aloys C.M., additional, Kroon, Frank P., additional, Kubin, Christine J., additional, La Rosa, Alberto M., additional, Lalani, Tahaniyat, additional, Lalloo, David G., additional, Lambert, Harold, additional, Landraud, Luce, additional, Lawn, Stephen D., additional, Pharm, Phillipe Lehours, additional, Leone, Marc, additional, Levi, Itzchak, additional, Levitt, Alexandra M., additional, Lindquist, H. D. Alan, additional, Lloyd, Graham, additional, Looney, David J., additional, Lowy, Franklin D., additional, Luft, Benjamin J., additional, Lynn, William A., additional, Macielag, Mark J., additional, Mackowiak, Philip A., additional, MacPherson, Paul A., additional, Maghraoui-Slim, Valérie, additional, Main, Janice, additional, Mallet, Vincent, additional, Mangino, Julie E., additional, Manuel, Oriol, additional, Marchetti, Oscar, additional, Marks, Kristen, additional, Marr, Kieren A., additional, Martin, Claude, additional, Martín-Rabadán, Pablo, additional, Martinez, Augusto Julio, additional, Mascini, Ellen M., additional, Mayer, Kenneth H., additional, McCormick, Joseph B., additional, McGready, Rose, additional, McKendrick, Michael W., additional, Mead, Simon, additional, Mégraud, Francis, additional, Meheus, André Z., additional, Meintjes, Graeme, additional, Michaels, Marian G., additional, Miles, Michael, additional, Miller, Alastair, additional, Mimiaga, Matthew J., additional, Mingeot-Leclercq, Marie-Paule, additional, Mitchell, Thomas G., additional, Moise, Pamela A., additional, Montaner, Julio, additional, Moore, Caroline B., additional, Moreillon, Philippe, additional, Morgan-Capner, Peter, additional, Montessori, Valentina, additional, Moss, Peter, additional, Muñoz, Patricia, additional, Naber, Kurt G., additional, Nakhla, Sammy, additional, Narain, Jai P., additional, Nathwani, Dilip, additional, Newton, Paul, additional, Nguyen, Chinh, additional, Nicolle, Lindsay E., additional, Niederman, Michael S., additional, Noel, Gary J., additional, Norrby, S. Ragnar, additional, Nosten, François, additional, Notarangelo, Luigi Daniele, additional, Nyirjesy, Paul, additional, O'Connell, P. Ronan, additional, Odorico, Jon S., additional, Ong, Edmund L.C., additional, Opal, Steven M., additional, Ormerod, L. Peter, additional, Osmon, Douglas R., additional, Ottesen, Eric A., additional, Palacios, Gustavo, additional, Pantaleo, Giuseppe, additional, Papazian, Laurent, additional, Parola, Philippe, additional, Pascual, Manuel A., additional, Patrozou, Eleni, additional, Paya, Carlos, additional, Peacock, Sharon J., additional, Pechère, Jean-Claude, additional, Perkins, Mark D., additional, Peters, Barry, additional, Pfyffer, Gaby E., additional, Pham, Paul A., additional, Piot, Peter, additional, Placko-Parola, Geraldine, additional, Pol, Stainslas, additional, Posfay-Barbe, Klara M., additional, Powderly, William G., additional, Pozniak, Anton, additional, Prod'hom, Guy, additional, Quinn, Thomas C., additional, Rahn, Daniel W., additional, Rana, Aadia I., additional, Raoult, Didier, additional, Raz, Raul, additional, Razonable, Raymund, additional, Read, Robert C., additional, Reynolds, Stephen J., additional, Richardson, Malcolm D., additional, Robinson, Christopher C., additional, Rooijakkers, Suzan H.M., additional, Rosenbluth, Daniel, additional, Rosenzweig, Sergio D., additional, Rovery, Clarisse, additional, Rubin, Robert H., additional, Rubinovitch, Bina, additional, Rubins, Kathleen H., additional, Rubinstein, Ethan, additional, Ryan, Greg, additional, Ryder, Stephen, additional, Safren, Steven, additional, Sahasrabuddhe, Vikrant V., additional, Saikku, Pekka A.I., additional, Sakoulas, George, additional, Salazar, Juan Carlos, additional, Salvaggio, Michelle R., additional, Schaffer, Kirsten, additional, Schmitz, Franz-Josef, additional, Schooley, Robert T., additional, Schumacher, Richard-Fabian, additional, Scrimgeour, Euan M., additional, Seddon, James, additional, Seifert, Harald, additional, Serjeant, Graham R., additional, Sha, Beverly E., additional, Shah, Keerti V., additional, Shapiro, Daniel S., additional, Sheehan, Gerard, additional, Shoham, Shmuel, additional, Simmons, Cameron P., additional, Simonsen, Kari A., additional, Singh, Neeraj, additional, Slack, Mary P.E., additional, Sobel, Jack D., additional, Sopirala, Madhuri M., additional, Spacek, Lisa A., additional, Sriskandan, Shiranee, additional, Stanley, Samuel L., additional, Steckelberg, James M., additional, Stephenson, Iain, additional, Stevens, Dennis L., additional, Straus, Walter L., additional, Sturm, Willem, additional, Summerbell, Richard C., additional, Susa, Joseph S., additional, Tabrizi, Sarah J., additional, Tack, Marc A., additional, Taplitz, Randy, additional, Tebas, Pablo, additional, Temmerman, Marleen, additional, Thijsen, Steven F.T., additional, Thomas, Lora D., additional, Thomson, Gail, additional, Thwaites, Guy E., additional, Tirelli, Umberto, additional, Tolkoff-Rubin, Nina E., additional, Tønjum, Tone, additional, Torriani, Francesca J., additional, Townsend, Gregory C., additional, Masó, Gloria Trallero, additional, Tulkens, Paul M., additional, Tunkel, Allan R., additional, Vaccher, Emanuela, additional, Vallet-Pichard, Anaïs, additional, Van Bambeke, Françoise, additional, van de Beek, Diederik, additional, van der Meer, Jos W.M., additional, van Loon, Anton M., additional, van Putten, Jos, additional, Vaudaux, Bernard P., additional, Vermund, Sten H., additional, Verstraelen, Hans, additional, Verweij, Paul, additional, Viscidi, Raphael P., additional, Visvanathan, Kumar, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wagenlehner, Florian M.E., additional, Wahl-Jensen, Victoria, additional, Walsh, Thomas J., additional, Warhurst, David C., additional, Warnock, David W., additional, Warrell, David A., additional, Warrell, Mary J., additional, Warris, Adilia, additional, Weber, Rainer, additional, Weidner, Wolfgang, additional, Weston, Vivienne C., additional, Whimbey, Estella, additional, Whitby, Michael, additional, White, Peter J., additional, Whitty, Christopher J.M., additional, Willems, Rob J.L., additional, Williams, Emrys, additional, Wilson, Cara, additional, Wilson, Mary E., additional, Winn, Richard E., additional, Winthrop, Kevin L., additional, Wiselka, Martin J., additional, Wisplinghoff, Hilmar, additional, Wolfe, Cameron R., additional, Wood, Robin, additional, Wright, Natalie, additional, Yankaskas, James R., additional, Zaidi, Najam A., additional, Zenilman, Jonathan M., additional, Zhang, Yaobi, additional, Zuckerman, Arie J., additional, Zuckerman, Jane Nicola, additional, and Zumla, Alimuddin, additional

Published
2010
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43. The German Chronic Kidney Disease (GCKD) study: design and methods

Author

Eckardt, Kai-Uwe, Bärthlein, Barbara, Baid-Agrawal, Seema, Beck, Andreas, Busch, Martin, Eitner, Frank, Ekici, Arif B., Floege, Jürgen, Gefeller, Olaf, Haller, Hermann, Hilge, Robert, Hilgers, Karl F., Kielstein, Jan T., Krane, Vera, Köttgen, Anna, Kronenberg, Florian, Oefner, Peter, Prokosch, Hans-Ulrich, Reis, André, Schmid, Matthias, Schaeffner, Elke, Schultheiss, Ulla T., Seuchter, Susanne A., Sitter, Thomas, Sommerer, Claudia, Walz, Gerd, Wanner, Christoph, Wolf, Gunter, Zeier, Martin, and Titze, Stephanie

Published
2012
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44. Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease

Author

Fazzini, Federica, primary, Lamina, Claudia, additional, Raschenberger, Julia, additional, Schultheiss, Ulla T., additional, Kotsis, Fruzsina, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Forer, Lukas, additional, Steinbrenner, Inga, additional, Meiselbach, Heike, additional, Bärthlein, Barbara, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Köttgen, Anna, additional, Kronenberg, Florian, additional, Schneider, Markus, additional, Dienemann, Thomas, additional, Prokosch, Hans-Ulrich, additional, Beck, Andreas, additional, Ganslandt, Thomas, additional, Reis, André, additional, Ekici, Arif B., additional, Avendaño, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Zitzmann, Rita, additional, Weigel, Anke, additional, Walz, Gerd, additional, Schultheiß, Ulla T., additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Schlieper, Georg, additional, Saritas, Turgay, additional, Ernst, Sabine, additional, Beaujean, Nicole, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Woitke, Rebecca, additional, Wolf, Gunter, additional, Busch, Martin, additional, Fuß, Rainer, additional, Sitter, Thomas, additional, Blank, Claudia, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kollerits, Barbara, additional, Oefner, Peter, additional, Gronwald, Wolfram, additional, Zacharias, Helena, additional, Schmid, Matthias, additional, and Nadal, Jennifer, additional

Published
2020
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45. Status of periodontal health in German patients suffering from chronic kidney disease—Data from the GCKD study

Author

Dannewitz, Bettina, primary, Sommerer, Claudia, additional, Stölzel, Peggy, additional, Baid‐Agrawal, Seema, additional, Nadal, Jennifer, additional, Bärthlein, Barbara, additional, Wanner, Christoph, additional, Eckardt, Kai‐Uwe, additional, Zeier, Martin, additional, Schlagenhauf, Ulrich, additional, Krane, Vera, additional, and Jockel‐Schneider, Yvonne, additional

Published
2019
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46. Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease

Author

Alencar de Pinho, Natalia, primary, Levin, Adeera, additional, Fukagawa, Masafumi, additional, Hoy, Wendy E., additional, Pecoits-Filho, Roberto, additional, Reichel, Helmut, additional, Robinson, Bruce, additional, Kitiyakara, Chagriya, additional, Wang, Jinwei, additional, Eckardt, Kai-Uwe, additional, Jha, Vivekanand, additional, Oh, Kook-Hwan, additional, Sola, Laura, additional, Eder, Susanne, additional, de Borst, Martin, additional, Taal, Maarten, additional, Feldman, Harold I., additional, Stengel, Bénédicte, additional, Djurdjev, Ognjenka, additional, Tang, Mila, additional, Fujii, Naohiki, additional, Maruyama, Shoichi, additional, Imaizumi, Takahiro, additional, Zhang, Jianzhen, additional, Wang, Zaimin, additional, Healy, Helen G., additional, Alencar de Pinho, Natalia, additional, Massy, Ziad A., additional, Combe, Christian, additional, Laville, Maurice, additional, Filho, Roberto Pecoits, additional, Lopes, Antonio, additional, Pisoni, Ronald, additional, Bieber, Brian, additional, Tu, Charlotte, additional, Sangthawan, Pornpen, additional, Pichaiwong, Warangkana, additional, Klyprayong, Pinkaew, additional, Orlandi, Paula, additional, Townsend, Raymond, additional, Go, Alan, additional, Zhang, Luxia, additional, Kumar, Vivek, additional, Yadav, Ashok Kumar, additional, Baid-Agrawal, Seema, additional, Ahn, Curie, additional, Chae, Dong Wan, additional, Han, Seung Hyeok, additional, Rios, Pablo G., additional, Gadola, Liliana, additional, Lamadrid, Veronica, additional, Leierer, Johannes, additional, Kerschbaum, Julia, additional, de Borst, Martin H., additional, Van Ittersum, Frans J., additional, Van den Brand, Jan A., additional, De Jong, Maarten A., additional, Taal, Maarten W., additional, and Shardlow, Adam, additional

Published
2019
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48. Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease

Author

Fazzini, Federica, Lamina, Claudia, Eckardt, Kai-Uwe, Köttgen, Anna, Kronenberg, Florian, GCKD Investigators, Meiselbach, Heike, Schneider, Markus, Dienemann, Thomas, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Fendt, Liane, Beck, Andreas, Ganslandt, Thomas, Reis, André, Ekici, Arif B., Avendaño, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Zitzmann, Rita, Weigel, Anke, Schultheiss, Ulla T., Walz, Gerd, Schultheiß, Ulla, Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Flöge, Jürgen, Schlieper, Georg, Saritas, Turgay, Ernst, Sabine, Beaujean, Nicole, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Woitke, Rebecca, Hicks, Andrew A., Wolf, Gunter, Busch, Martin, Fuß, Rainer, Sitter, Thomas, Blank, Claudia, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, Schmid, Matthias, and Nadal, Jennifer

Subjects
Male, DNA Copy Number Variations, Kaplan-Meier Estimate, Middle Aged, Infections, Prognosis, DNA, Mitochondrial, Mitochondria, Hospitalization, Oxidative Stress, Cardiovascular Diseases, Risk Factors, Cause of Death, Germany, Prevalence, Humans, Female, Prospective Studies, Renal Insufficiency, Chronic, Aged, Follow-Up Studies, Proportional Hazards Models
Abstract

Kidney international 96(2), 480-488 (2019). doi:10.1016/j.kint.2019.04.021, Published by Elsevier, New York, NY

Published
2019
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50. Thyroid function, renal events and mortality in chronic kidney disease patients: the German Chronic Kidney Disease study.

Author

Schultheiss, Ulla T, Steinbrenner, Inga, Nauck, Matthias, Schneider, Markus P, Kotsis, Fruzsina, Baid-Agrawal, Seema, Schaeffner, Elke, Eckardt, Kai-Uwe, Köttgen, Anna, Sekula, Peggy, and investigators, the GCKD

Subjects
CHRONIC kidney failure, CHRONICALLY ill, ACUTE kidney failure, THYROID gland, PROPORTIONAL hazards models
Abstract

Background Hypothyroidism and low free triiodothyronine (FT3) syndrome [low FT3 levels with normal thyroid-stimulating hormone (TSH)] have been associated with reduced kidney function cross-sectionally in chronic kidney disease (CKD) patients with severely reduced estimated glomerular filtration rate (eGFR) or end-stage kidney disease (ESKD). Results on the prospective effects of impaired thyroid function on renal events and mortality for patients with severely reduced eGFR or from population-based cohorts are conflicting. Here we evaluated the association between thyroid and kidney function with eGFR (cross-sectionally) as well as renal events and mortality (prospectively) in a large, prospective cohort of CKD patients with mild to moderately reduced kidney function. Methods Thyroid markers were measured among CKD patients from the German Chronic Kidney Disease study. Incident renal endpoints (combined ESKD, acute kidney injury and renal death) and all-cause mortality were abstracted from hospital records and death certificates. Time to first event analysis of complete data from baseline to the 4-year follow-up (median follow-up time 4.04 years) of 4600 patients was conducted. Multivariable linear regression and Cox proportional hazards models were fitted for single and combined continuous thyroid markers [TSH, free thyroxine (FT4), FT3] and thyroid status. Results Cross-sectionally, the presence of low-FT3 syndrome showed a significant inverse association with eGFR and continuous FT3 levels alone showed a significant positive association with eGFR; in combination with FT4 and TSH, FT3 levels also showed a positive association and FT4 levels showed a negative association with eGFR. Prospectively, higher FT4 and lower FT3 levels were significantly associated with a higher risk of all-cause mortality (N events = 297). Per picomole per litre higher FT3 levels the risk of reaching the composite renal endpoint was 0.73-fold lower (95% confidence interval 0.65–0.82; N events = 615). Compared with euthyroid patients, patients with low-FT3 syndrome had a 2.2-fold higher risk and patients with hypothyroidism had a 1.6-fold higher risk of experiencing the composite renal endpoint. Conclusions Patients with mild to moderate CKD suffering from thyroid function abnormalities are at an increased risk of adverse renal events and all-cause mortality over time. [ABSTRACT FROM AUTHOR]

Published
2021
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