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2. Boundary management preferences from a gender and cross-cultural perspective

Author

Allen, Tammy, Beham, Barbara, Ollier-Malaterre, Ariane, Baierl, Andreas, Alexandrova, Matilda, Artiawati, Beauregard, Alexandra, Carvalho, Vânia Sofia, Chambel, Maria José, Cho, Eunae, Coden da Silva, Bruna, Dawkins, Sarah, Escribano, Pablo, Gudeta, Konjit Hailu, Huang, Ting-pang, Jaga, Ameeta, Kost, Dominique, Kurowska, Anna, Leon, Emmanuelle, Lewis, Suzan, Lu, Chang-qin, Martin, Angela, Morandin, Gabriele, Noboa, Fabrizio, Offer, Shira, Ohu, Eugene, Peters, Pascale, Rajadhyaksha, Ujvala, Russo, Marcello, Sohn, Young Woo, Straub, Caroline, Tammelin, Mia, Van Engen, Marloes, and Waismel-Manor, Ronit

Published
2024
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5. Higher vitamin B6 status is associated with improved survival among patients with stage I–III colorectal cancer

Author

Holowatyj, Andreana N, Ose, Jennifer, Gigic, Biljana, Lin, Tengda, Ulvik, Arve, Geijsen, Anne JMR, Brezina, Stefanie, Kiblawi, Rama, van Roekel, Eline H, Baierl, Andreas, Böhm, Jürgen, Bours, Martijn JL, Brenner, Hermann, Breukink, Stéphanie O, Chang-Claude, Jenny, de Wilt, Johannes HW, Grady, William M, Grünberger, Thomas, Gumpenberger, Tanja, Herpel, Esther, Hoffmeister, Michael, Keulen, Eric TP, Kok, Dieuwertje E, Koole, Janna L, Kosma, Katharina, Kouwenhoven, Ewout A, Kvalheim, Gry, Li, Christopher I, Schirmacher, Peter, Schrotz-King, Petra, Singer, Marie C, van Duijnhoven, Fränzel JB, van Halteren, Henk K, Vickers, Kathy, Vogelaar, F Jeroen, Warby, Christy A, Wesselink, Evertine, Ueland, Per M, Ulrich, Alexis B, Schneider, Martin, Habermann, Nina, Kampman, Ellen, Weijenberg, Matty P, Gsur, Andrea, and Ulrich, Cornelia M

Published
2022
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6. Circulating tryptophan–kynurenine pathway metabolites are associated with all‐cause mortality among patients with stage I–III colorectal cancer.

Author

Damerell, Victoria, Klaassen‐Dekker, Niels, Brezina, Stefanie, Ose, Jennifer, Ulvik, Arve, van Roekel, Eline H., Holowatyj, Andreana N., Baierl, Andreas, Böhm, Jürgen, Bours, Martijn J. L., Brenner, Hermann, de Wilt, Johannes H. W., Grady, William M., Habermann, Nina, Hoffmeister, Michael, Keski‐Rahkonen, Pekka, Lin, Tengda, Schirmacher, Peter, Schrotz‐King, Petra, and Ulrich, Alexis B.

Subjects
PICOLINIC acid, QUINOLINIC acid, AMINOBENZOIC acids, COLORECTAL cancer, ETIOLOGY of cancer
Abstract

Alterations within the tryptophan–kynurenine metabolic pathway have been linked to the etiology of colorectal cancer (CRC), but the relevance of this pathway for prognostic outcomes in CRC patients needs further elucidation. Therefore, we investigated associations between circulating concentrations of tryptophan–kynurenine pathway metabolites and all‐cause mortality among CRC patients. This study utilizes data from 2102 stage I–III CRC patients participating in six prospective cohorts involved in the international FOCUS Consortium. Preoperative circulating concentrations of tryptophan, kynurenine, kynurenic acid (KA), 3‐hydroxykynurenine (HK), xanthurenic acid (XA), 3‐hydroxyanthranilic acid (HAA), anthranilic acid (AA), picolinic acid (PA), and quinolinic acid (QA) were measured by liquid chromatography–tandem mass spectrometry. Using Cox proportional hazards regression, we examined associations of above‐mentioned metabolites with all‐cause mortality, adjusted for potential confounders. During a median follow‐up of 3.2 years (interquartile range: 2.2–4.9), 290 patients (13.8%) deceased. Higher blood concentrations of tryptophan, XA, and PA were associated with a lower risk of all‐cause mortality (per doubling in concentrations: tryptophan: HR = 0.56; 95%CI:0.41,0.76, XA: HR = 0.74; 95%CI:0.64,0.85, PA: HR = 0.76; 95%CI:0.64,0.92), while higher concentrations of HK and QA were associated with an increased risk of death (per doubling in concentrations: HK: HR = 1.80; 95%CI:1.47,2.21, QA: HR = 1.31; 95%CI:1.05,1.63). A higher kynurenine‐to‐tryptophan ratio, a marker of cell‐mediated immune activation, was associated with an increased risk of death (per doubling: HR = 2.07; 95%CI:1.52,2.83). In conclusion, tryptophan–kynurenine pathway metabolites may be prognostic markers of survival in CRC patients. [ABSTRACT FROM AUTHOR]

Published
2025
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10. Effizienz

Author

Obszelka, Daniel, Baierl, Andreas, Obszelka, Daniel, and Baierl, Andreas

Published
2020
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21. Matrizen

Author

Obszelka, Daniel, Baierl, Andreas, Obszelka, Daniel, and Baierl, Andreas

Published
2020
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26. Dataframes

Author

Obszelka, Daniel, Baierl, Andreas, Obszelka, Daniel, and Baierl, Andreas

Published
2020
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29. Listen

Author

Obszelka, Daniel, Baierl, Andreas, Obszelka, Daniel, and Baierl, Andreas

Published
2020
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45. Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium

Author

Koole, Janna L, Bours, Martijn JL, Geijsen, Anne JMR, Gigic, Biljana, Ulvik, Arve, Kok, Dieuwertje E, Brezina, Stefanie, Ose, Jennifer, Baierl, Andreas, Böhm, Jürgen, Brenner, Hermann, Breukink, Stéphanie O, Chang-Claude, Jenny, van Duijnhoven, Fränzel JB, van Duijvendijk, Peter, Gumpenberger, Tanja, Habermann, Nina, van Halteren, Henk K, Hoffmeister, Michael, Holowatyj, Andreana N, Janssen-Heijnen, Maryska LG, Keulen, Eric TP, Kiblawi, Rama, Kruyt, Flip M, Li, Christopher I, Lin, Tengda, Midttun, Øivind, Peoples, Anita R, van Roekel, Eline H, Schneider, Martin A, Schrotz-King, Petra, Ulrich, Alexis B, Vickers, Kathy, Wesselink, Evertine, de Wilt, Johannes HW, Gsur, Andrea, Ueland, Per M, Ulrich, Cornelia M, Kampman, Ellen, and Weijenberg, Matty P

Published
2021
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49. Circulating tryptophan–kynurenine pathway metabolites are associated with all-cause mortality among patients with stage I–III colorectal cancer

Author

Damerell, Victoria, Klaassen-Dekker, Niels, Brezina, Stefanie, Ose, Jennifer, Ulvik, Arve, van Roekel, Eline H., Holowatyj, Andreana N., Baierl, Andreas, Böhm, Jürgen, Bours, Martijn J.L., Brenner, Hermann, de Wilt, Johannes H.W., Grady, William M., Habermann, Nina, Hoffmeister, Michael, Keski-Rahkonen, Pekka, Lin, Tengda, Schirmacher, Peter, Schrotz-King, Petra, Ulrich, Alexis B., van Duijnhoven, Fränzel J.B., Warby, Christy A., Shibata, David, Toriola, Adetunji T., Figueiredo, Jane C., Siegel, Erin M., Li, Christopher I., Gsur, Andrea, Kampman, Ellen, Schneider, Martin, Ueland, Per M., Weijenberg, Matty P., Ulrich, Cornelia M., Kok, Dieuwertje E., Gigic, Biljana, Damerell, Victoria, Klaassen-Dekker, Niels, Brezina, Stefanie, Ose, Jennifer, Ulvik, Arve, van Roekel, Eline H., Holowatyj, Andreana N., Baierl, Andreas, Böhm, Jürgen, Bours, Martijn J.L., Brenner, Hermann, de Wilt, Johannes H.W., Grady, William M., Habermann, Nina, Hoffmeister, Michael, Keski-Rahkonen, Pekka, Lin, Tengda, Schirmacher, Peter, Schrotz-King, Petra, Ulrich, Alexis B., van Duijnhoven, Fränzel J.B., Warby, Christy A., Shibata, David, Toriola, Adetunji T., Figueiredo, Jane C., Siegel, Erin M., Li, Christopher I., Gsur, Andrea, Kampman, Ellen, Schneider, Martin, Ueland, Per M., Weijenberg, Matty P., Ulrich, Cornelia M., Kok, Dieuwertje E., and Gigic, Biljana

Abstract

Alterations within the tryptophan–kynurenine metabolic pathway have been linked to the etiology of colorectal cancer (CRC), but the relevance of this pathway for prognostic outcomes in CRC patients needs further elucidation. Therefore, we investigated associations between circulating concentrations of tryptophan–kynurenine pathway metabolites and all-cause mortality among CRC patients. This study utilizes data from 2102 stage I–III CRC patients participating in six prospective cohorts involved in the international FOCUS Consortium. Preoperative circulating concentrations of tryptophan, kynurenine, kynurenic acid (KA), 3-hydroxykynurenine (HK), xanthurenic acid (XA), 3-hydroxyanthranilic acid (HAA), anthranilic acid (AA), picolinic acid (PA), and quinolinic acid (QA) were measured by liquid chromatography–tandem mass spectrometry. Using Cox proportional hazards regression, we examined associations of above-mentioned metabolites with all-cause mortality, adjusted for potential confounders. During a median follow-up of 3.2 years (interquartile range: 2.2–4.9), 290 patients (13.8%) deceased. Higher blood concentrations of tryptophan, XA, and PA were associated with a lower risk of all-cause mortality (per doubling in concentrations: tryptophan: HR = 0.56; 95%CI:0.41,0.76, XA: HR = 0.74; 95%CI:0.64,0.85, PA: HR = 0.76; 95%CI:0.64,0.92), while higher concentrations of HK and QA were associated with an increased risk of death (per doubling in concentrations: HK: HR = 1.80; 95%CI:1.47,2.21, QA: HR = 1.31; 95%CI:1.05,1.63). A higher kynurenine-to-tryptophan ratio, a marker of cell-mediated immune activation, was associated with an increased risk of death (per doubling: HR = 2.07; 95%CI:1.52,2.83). In conclusion, tryptophan–kynurenine pathway metabolites may be prognostic markers of survival in CRC patients.

Published
2024

50. Boundary management preferences from a gender and cross-cultural perspective

Author

Allen, T.D., Beham, B., Ollier-Malaterre, Ariane, Baierl, Andreas, Alexandrova, M., Artiawati, ., Beauregard, Alexandra, Carvalho, Vânia Sofia, Chambel, Maria José, Cho, Eunae, Silva, Bruna Coden da, Dawkins, Sarah, Escribano, Pablo, Gudeta, Konjit Hailu, Huang, Ting-pang, Jaga, Ameeta, Kost, Dominique, Kurowska, Anna, Leon, Emmanuelle, Lewis, Suzan, Lu, C.Q., Martin, Angela, Morandin, Gabriele, Noboa, Fabrizio, Offer, Shira, Ohu, Eugene, Peters, P., Rajadhyaksha, Ujvala, Russo, Marcello, Sohn, Young Woo, Straub, Caroline, Tammelin, Mia, Engen, M.L. van, Waismel-Manor, Ronit, Allen, T.D., Beham, B., Ollier-Malaterre, Ariane, Baierl, Andreas, Alexandrova, M., Artiawati, ., Beauregard, Alexandra, Carvalho, Vânia Sofia, Chambel, Maria José, Cho, Eunae, Silva, Bruna Coden da, Dawkins, Sarah, Escribano, Pablo, Gudeta, Konjit Hailu, Huang, Ting-pang, Jaga, Ameeta, Kost, Dominique, Kurowska, Anna, Leon, Emmanuelle, Lewis, Suzan, Lu, C.Q., Martin, Angela, Morandin, Gabriele, Noboa, Fabrizio, Offer, Shira, Ohu, Eugene, Peters, P., Rajadhyaksha, Ujvala, Russo, Marcello, Sohn, Young Woo, Straub, Caroline, Tammelin, Mia, Engen, M.L. van, and Waismel-Manor, Ronit

Abstract

Item does not contain fulltext, 30 november 2023

Published
2024

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