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Recent analytical work reveals the need to assess mediated interactions (independent variable-by-mediator multiplicative terms) in mediation models to ensure the proper reporting of indirect effects. Besides their analytical value, mediated interactions can aid theory development. This study adds a theoretical support structure to this emergent analytical imperative and provides a theory-driven decision tree for incorporating mediated interactions into communication models. More broadly, mediated interactions are used as a basis to encourage the field to move beyond a "one variable, one role" approach to model building. Monte Carlo simulations reflecting common communication research practices were constructed and 1,920,000 datasets were analyzed to reveal the relative upsides and minimal risk incurred from assessing mediated interactions. In addition, the analyses elucidate the downsides incurred from not exploring these relationships when they are present in a population. The implications of these findings for future research and theory development are explored. [ABSTRACT FROM AUTHOR]

CRISPR technologies are advancing at a dizzying pace, and emerging cultural, sociopolitical, ethical, and legal implications continue to pose new challenges for public engagement. Recent calls for public engagement and dialogue on CRISPR applications stress the importance of nuanced thinking and responsible communication. In this chapter, we review public opinion research and find that a comprehensive and clear picture of global views on CRISPR is missing but is necessary to build the foundation for effective public engagement programs. We recommend community-based-participatory research as an inclusive and effective framework for shared knowledge production and decision-making practices for scientific experts and science communicators to engage in genuine and meaningful dialogue with community members in making informed consideration for important value-laden decisions. In response to the politicization of science, this chapter offers strategic communication techniques that can help those facilitating public engagement of CRISPR-based technologies keep cognitive biases, such as identity protective cognition, motivated reasoning, and confirmation bias, at bay., (Copyright © 2022 Elsevier Inc. All rights reserved.)