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360 results on '"Bailey, Susan M."'

1. The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Author

Overbey, Eliah G., Kim, JangKeun, Tierney, Braden T., Park, Jiwoon, Houerbi, Nadia, Lucaci, Alexander G., Garcia Medina, Sebastian, Damle, Namita, Najjar, Deena, Grigorev, Kirill, Afshin, Evan E., Ryon, Krista A., Sienkiewicz, Karolina, Patras, Laura, Klotz, Remi, Ortiz, Veronica, MacKay, Matthew, Schweickart, Annalise, Chin, Christopher R., Sierra, Maria A., Valenzuela, Matias F., Dantas, Ezequiel, Nelson, Theodore M., Cekanaviciute, Egle, Deards, Gabriel, Foox, Jonathan, Narayanan, S. Anand, Schmidt, Caleb M., Schmidt, Michael A., Schmidt, Julian C., Mullane, Sean, Tigchelaar, Seth Stravers, Levitte, Steven, Westover, Craig, Bhattacharya, Chandrima, Lucotti, Serena, Wain Hirschberg, Jeremy, Proszynski, Jacqueline, Burke, Marissa, Kleinman, Ashley S., Butler, Daniel J., Loy, Conor, Mzava, Omary, Lenz, Joan, Paul, Doru, Mozsary, Christopher, Sanders, Lauren M., Taylor, Lynn E., Patel, Chintan O., Khan, Sharib A., Suhail Mohamad, Mir, Byhaqui, Syed Gufran Ahmad, Aslam, Burhan, Gajadhar, Aaron S., Williamson, Lucy, Tandel, Purvi, Yang, Qiu, Chu, Jessica, Benz, Ryan W., Siddiqui, Asim, Hornburg, Daniel, Blease, Kelly, Moreno, Juan, Boddicker, Andrew, Zhao, Junhua, Lajoie, Bryan, Scott, Ryan T., Gilbert, Rachel R., Lai Polo, San-huei, Altomare, Andrew, Kruglyak, Semyon, Levy, Shawn, Ariyapala, Ishara, Beer, Joanne, Zhang, Bingqing, Hudson, Briana M., Rininger, Aric, Church, Sarah E., Beheshti, Afshin, Church, George M., Smith, Scott M., Crucian, Brian E., Zwart, Sara R., Matei, Irina, Lyden, David C., Garrett-Bakelman, Francine, Krumsiek, Jan, Chen, Qiuying, Miller, Dawson, Shuga, Joe, Williams, Stephen, Nemec, Corey, Trudel, Guy, Pelchat, Martin, Laneuville, Odette, De Vlaminck, Iwijn, Gross, Steven, Bolton, Kelly L., Bailey, Susan M., Granstein, Richard, Furman, David, Melnick, Ari M., Costes, Sylvain V., Shirah, Bader, Yu, Min, Menon, Anil S., Mateus, Jaime, Meydan, Cem, and Mason, Christopher E.

Published
2024
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2. A second space age spanning omics, platforms and medicine across orbits

Author

Mason, Christopher E., Green, James, Adamopoulos, Konstantinos I., Afshin, Evan E., Baechle, Jordan J., Basner, Mathias, Bailey, Susan M., Bielski, Luca, Borg, Josef, Borg, Joseph, Broddrick, Jared T., Burke, Marissa, Caicedo, Andrés, Castañeda, Verónica, Chatterjee, Subhamoy, Chin, Christopher R., Church, George, Costes, Sylvain V., De Vlaminck, Iwijn, Desai, Rajeev I., Dhir, Raja, Diaz, Juan Esteban, Etlin, Sofia M., Feinstein, Zachary, Furman, David, Garcia-Medina, J. Sebastian, Garrett-Bakelman, Francine, Giacomello, Stefania, Gupta, Anjali, Hassanin, Amira, Houerbi, Nadia, Irby, Iris, Javorsky, Emilia, Jirak, Peter, Jones, Christopher W., Kamal, Khaled Y., Kangas, Brian D., Karouia, Fathi, Kim, JangKeun, Kim, Joo Hyun, Kleinman, Ashley S., Lam, Try, Lawler, John M., Lee, Jessica A., Limoli, Charles L., Lucaci, Alexander, MacKay, Matthew, McDonald, J. Tyson, Melnick, Ari M., Meydan, Cem, Mieczkowski, Jakub, Muratani, Masafumi, Najjar, Deena, Othman, Mariam A., Overbey, Eliah G., Paar, Vera, Park, Jiwoon, Paul, Amber M., Perdyan, Adrian, Proszynski, Jacqueline, Reynolds, Robert J., Ronca, April E., Rubins, Kate, Ryon, Krista A., Sanders, Lauren M., Glowe, Patricia Savi, Shevde, Yash, Schmidt, Michael A., Scott, Ryan T., Shirah, Bader, Sienkiewicz, Karolina, Sierra, Maria A., Siew, Keith, Theriot, Corey A., Tierney, Braden T., Venkateswaran, Kasthuri, Hirschberg, Jeremy Wain, Walsh, Stephen B., Walter, Claire, Winer, Daniel A., Yu, Min, Zea, Luis, Mateus, Jaime, and Beheshti, Afshin

Published
2024
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7. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Author

Garrett-Bakelman, Francine E, Darshi, Manjula, Green, Stefan J, Gur, Ruben C, Lin, Ling, Macias, Brandon R, McKenna, Miles J, Meydan, Cem, Mishra, Tejaswini, Nasrini, Jad, Piening, Brian D, Rizzardi, Lindsay F, Sharma, Kumar, Siamwala, Jamila H, Taylor, Lynn, Vitaterna, Martha Hotz, Afkarian, Maryam, Afshinnekoo, Ebrahim, Ahadi, Sara, Ambati, Aditya, Arya, Maneesh, Bezdan, Daniela, Callahan, Colin M, Chen, Songjie, Choi, Augustine MK, Chlipala, George E, Contrepois, Kévin, Covington, Marisa, Crucian, Brian E, De Vivo, Immaculata, Dinges, David F, Ebert, Douglas J, Feinberg, Jason I, Gandara, Jorge A, George, Kerry A, Goutsias, John, Grills, George S, Hargens, Alan R, Heer, Martina, Hillary, Ryan P, Hoofnagle, Andrew N, Hook, Vivian YH, Jenkinson, Garrett, Jiang, Peng, Keshavarzian, Ali, Laurie, Steven S, Lee-McMullen, Brittany, Lumpkins, Sarah B, MacKay, Matthew, Maienschein-Cline, Mark G, Melnick, Ari M, Moore, Tyler M, Nakahira, Kiichi, Patel, Hemal H, Pietrzyk, Robert, Rao, Varsha, Saito, Rintaro, Salins, Denis N, Schilling, Jan M, Sears, Dorothy D, Sheridan, Caroline K, Stenger, Michael B, Tryggvadottir, Rakel, Urban, Alexander E, Vaisar, Tomas, Van Espen, Benjamin, Zhang, Jing, Ziegler, Michael G, Zwart, Sara R, Charles, John B, Kundrot, Craig E, Scott, Graham BI, Bailey, Susan M, Basner, Mathias, Feinberg, Andrew P, Lee, Stuart MC, Mason, Christopher E, Mignot, Emmanuel, Rana, Brinda K, Smith, Scott M, Snyder, Michael P, and Turek, Fred W

Subjects
Mental Health, Genetics, Adaptation, Physiological, Adaptive Immunity, Astronauts, Body Weight, Carotid Arteries, Carotid Intima-Media Thickness, DNA Damage, DNA Methylation, Gastrointestinal Microbiome, Genomic Instability, Humans, Male, Space Flight, Telomere Homeostasis, Time Factors, United States, United States National Aeronautics and Space Administration, General Science & Technology
Abstract

To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.

Published
2019

8. Increased Reproductive Output and Telomere Shortening Following Calcium Supplementation in a Wild Songbird.

Author

Rodriguez, Marina D., Bailey, Susan M., Doherty, Paul F., and Huyvaert, Kathryn P.

Subjects
*LIFE history theory, *CALCIUM supplements, *CALCIUM, *TELOMERES, *SONGBIRDS, *LONGEVITY, *REPRODUCTION
Abstract

Life history theory predicts increased parental investment comes with fitness costs, often expressed as negative effects on survival and future reproduction. To better understand the costs of reproduction and life history trade‐offs, we evaluated calcium supplementation at a high‐elevation site in Colorado as a novel approach to experimentally alter reproductive investment in nesting female Tachycineta bicolor (tree swallow). Calcium is a nutrient critical to avian reproduction as the intake of natural calcium is essential for egg production, embryo development, and nestling growth. Altering calcium availability exclusively during the breeding season allowed examination of individual biological responses to experimental modification of reproduction, as well as the reproductive costs associated with egg production and laying an entire clutch. As a functional endpoint and proxy for fitness and longevity, telomere length was measured at the beginning and end of each breeding season. Telomeres—protective "caps" at the ends of chromosomes—have been shown to shorten with aging and a variety of stressors, including higher reproductive output. Results demonstrate that tree swallow mothers supplemented with calcium during the breeding season experience higher reproductive output and produce offspring with longer telomeres, which came at the cost of relatively shorter telomeres during the reproductive season. These findings provide additional support for reproductive trade‐offs, and also challenge previous calcium supplementation studies that suggest excess calcium reduces the cost of reproduction. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers

Author

Bezdan, Daniela, Grigorev, Kirill, Meydan, Cem, Pelissier Vatter, Fanny A., Cioffi, Michele, Rao, Varsha, MacKay, Matthew, Nakahira, Kiichi, Burnham, Philip, Afshinnekoo, Ebrahim, Westover, Craig, Butler, Daniel, Mozsary, Chris, Donahoe, Timothy, Foox, Jonathan, Mishra, Tejaswini, Lucotti, Serena, Rana, Brinda K., Melnick, Ari M., Zhang, Haiying, Matei, Irina, Kelsen, David, Yu, Kenneth, Lyden, David C., Taylor, Lynn, Bailey, Susan M., Snyder, Michael P., Garrett-Bakelman, Francine E., Ossowski, Stephan, De Vlaminck, Iwijn, and Mason, Christopher E.

Published
2020
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11. The Central Role of Cytogenetics in Radiation Biology.

Author

Bailey, Susan M., Kunkel, Stephen R., Bedford, Joel S., and Cornforth, Michael N.

Subjects
PHYSIOLOGICAL effects of radiation, RADIOBIOLOGY, CHROMOSOME abnormalities, DOUBLE-strand DNA breaks, CHROMOSOMAL rearrangement, TECHNOLOGICAL innovations
Abstract

Radiation cytogenetics has a rich history seldom appreciated by those outside the field. Early radiobiology was dominated by physics and biophysical concepts that borrowed heavily from the study of radiation-induced chromosome aberrations. From such studies, quantitative relationships between biological effect and changes in absorbed dose, dose rate and ionization density were codified into key concepts of radiobiological theory that have persisted for nearly a century. This review aims to provide a historical perspective of some of these concepts, including evidence supporting the contention that chromosome aberrations underlie development of many, if not most, of the biological effects of concern for humans exposed to ionizing radiations including cancer induction, on the one hand, and tumor eradication on the other. The significance of discoveries originating from these studies has widened and extended far beyond their original scope. Chromosome structural rearrangements viewed in mitotic cells were first attributed to the production of breaks by the radiations during interphase, followed by the rejoining or mis-rejoining among ends of other nearby breaks. These relatively modest beginnings eventually led to the discovery and characterization of DNA repair of double-strand breaks by non-homologous end joining, whose importance to various biological processes is now widely appreciated. Two examples, among many, are V(D)J recombination and speciation. Rapid technological advancements in cytogenetics, the burgeoning fields of molecular radiobiology and third-generation sequencing served as a point of confluence between the old and new. As a result, the emergent field of "cytogenomics" now becomes uniquely positioned for the purpose of more fully understanding mechanisms underlying the biological effects of ionizing radiation exposure. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Stress and telomere shortening among central Indian conservation refugees

Author

Zahran, Sammy, Snodgrass, Jeffrey G, Maranon, David G, Upadhyay, Chakrapani, Granger, Douglas A, and Bailey, Susan M

Subjects
Aging, Behavioral and Social Science, Clinical Research, Mental Health, Generic health relevance, Good Health and Well Being, Adult, Female, Humans, Hydrocortisone, Indians, North American, Longevity, Male, Stress, Psychological, Telomere, Telomere Homeostasis, India, human displacement, indigenous peoples, stress, telomeres
Abstract

Research links psychosocial stress to premature telomere shortening and accelerated human aging; however, this association has only been demonstrated in so-called "WEIRD" societies (Western, educated, industrialized, rich, and democratic), where stress is typically lower and life expectancies longer. By contrast, we examine stress and telomere shortening in a non-Western setting among a highly stressed population with overall lower life expectancies: poor indigenous people--the Sahariya--who were displaced (between 1998 and 2002) from their ancestral homes in a central Indian wildlife sanctuary. In this setting, we examined adult populations in two representative villages, one relocated to accommodate the introduction of Asiatic lions into the sanctuary (n = 24 individuals), and the other newly isolated in the sanctuary buffer zone after their previous neighbors were moved (n = 22). Our research strategy combined physical stress measures via the salivary analytes cortisol and α-amylase with self-assessments of psychosomatic stress, ethnographic observations, and telomere length assessment [telomere-fluorescence in situ hybridization (TEL-FISH) coupled with 3D imaging of buccal cell nuclei], providing high-resolution data amenable to multilevel statistical analysis. Consistent with expectations, we found significant associations between each of our stress measures--the two salivary analytes and the psychosomatic symptom survey--and telomere length, after adjusting for relevant behavioral, health, and demographic traits. As the first study (to our knowledge) to link stress to telomere length in a non-WEIRD population, our research strengthens the case for stress-induced telomere shortening as a pancultural biomarker of compromised health and aging.

Published
2015

20. Telomeres, chromosome instability and cancer

Author

Bailey, Susan M and Murnane, John P

Subjects
Biological Sciences, Genetics, Cancer, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Chromosomal Instability, Humans, Neoplasms, Repetitive Sequences, Nucleic Acid, Telomere, Environmental Sciences, Information and Computing Sciences, Developmental Biology, Biological sciences, Chemical sciences, Environmental sciences
Abstract

Telomeres are composed of repetitive G-rich sequence and an abundance of associated proteins that together form a dynamic cap that protects chromosome ends and allows them to be distinguished from deleterious DSBs. Telomere-associated proteins also function to regulate telomerase, the ribonucleoprtotein responsible for addition of the species-specific terminal repeat sequence. Loss of telomere function is an important mechanism for the chromosome instability commonly found in cancer. Dysfunctional telomeres can result either from alterations in the telomere-associated proteins required for end-capping function, or from alterations that promote the gradual or sudden loss of sufficient repeat sequence necessary to maintain proper telomere structure. Regardless of the mechanism, loss of telomere function can result in sister chromatid fusion and prolonged breakage/fusion/bridge (B/F/B) cycles, leading to extensive DNA amplification and large terminal deletions. B/F/B cycles terminate primarily when the unstable chromosome acquires a new telomere, most often by translocation of the ends of other chromosomes, thereby providing a mechanism for transfer of instability from one chromosome to another. Thus, the loss of a single telomere can result in on-going instability, affect multiple chromosomes, and generate many of the types of rearrangements commonly associated with human cancer.

Published
2006

24. Supplementary Tables 1-2 from Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

Author

Chernikova, Sophia B., primary, Razorenova, Olga V., primary, Higgins, John P., primary, Sishc, Brock J., primary, Nicolau, Monica, primary, Dorth, Jennifer A., primary, Chernikova, Diana A., primary, Kwok, Shirley, primary, Brooks, James D., primary, Bailey, Susan M., primary, Game, John C., primary, and Brown, J. Martin, primary

Published
2023
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25. Supplementary Figures 1-7 from Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

Author

Chernikova, Sophia B., primary, Razorenova, Olga V., primary, Higgins, John P., primary, Sishc, Brock J., primary, Nicolau, Monica, primary, Dorth, Jennifer A., primary, Chernikova, Diana A., primary, Kwok, Shirley, primary, Brooks, James D., primary, Bailey, Susan M., primary, Game, John C., primary, and Brown, J. Martin, primary

Published
2023
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28. Supplementary Materials and Methods from Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

Author

Chernikova, Sophia B., primary, Razorenova, Olga V., primary, Higgins, John P., primary, Sishc, Brock J., primary, Nicolau, Monica, primary, Dorth, Jennifer A., primary, Chernikova, Diana A., primary, Kwok, Shirley, primary, Brooks, James D., primary, Bailey, Susan M., primary, Game, John C., primary, and Brown, J. Martin, primary

Published
2023
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29. Supplementary Tables 3-5 from Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

Author

Chernikova, Sophia B., primary, Razorenova, Olga V., primary, Higgins, John P., primary, Sishc, Brock J., primary, Nicolau, Monica, primary, Dorth, Jennifer A., primary, Chernikova, Diana A., primary, Kwok, Shirley, primary, Brooks, James D., primary, Bailey, Susan M., primary, Game, John C., primary, and Brown, J. Martin, primary

Published
2023
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30. Data from Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability

Author

Chernikova, Sophia B., primary, Razorenova, Olga V., primary, Higgins, John P., primary, Sishc, Brock J., primary, Nicolau, Monica, primary, Dorth, Jennifer A., primary, Chernikova, Diana A., primary, Kwok, Shirley, primary, Brooks, James D., primary, Bailey, Susan M., primary, Game, John C., primary, and Brown, J. Martin, primary

Published
2023
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43. Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration

Author

Afshinnekoo, Ebrahim, primary, Scott, Ryan T., additional, MacKay, Matthew J., additional, Pariset, Eloise, additional, Cekanaviciute, Egle, additional, Barker, Richard, additional, Gilroy, Simon, additional, Hassane, Duane, additional, Smith, Scott M., additional, Zwart, Sara R., additional, Nelman-Gonzalez, Mayra, additional, Crucian, Brian E., additional, Ponomarev, Sergey A., additional, Orlov, Oleg I., additional, Shiba, Dai, additional, Muratani, Masafumi, additional, Yamamoto, Masayuki, additional, Richards, Stephanie E., additional, Vaishampayan, Parag A., additional, Meydan, Cem, additional, Foox, Jonathan, additional, Myrrhe, Jacqueline, additional, Istasse, Eric, additional, Singh, Nitin, additional, Venkateswaran, Kasthuri, additional, Keune, Jessica A., additional, Ray, Hami E., additional, Basner, Mathias, additional, Miller, Jack, additional, Vitaterna, Martha Hotz, additional, Taylor, Deanne M., additional, Wallace, Douglas, additional, Rubins, Kathleen, additional, Bailey, Susan M., additional, Grabham, Peter, additional, Costes, Sylvain V., additional, Mason, Christopher E., additional, and Beheshti, Afshin, additional

Published
2021
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44. Evaluation of DNA damage and stress in wildlife chronically exposed to low-dose, low-dose rate radiation from the Fukushima Dai-ichi Nuclear Power Plant accident

Author

Cunningham, Kelly, primary, Hinton, Thomas G., additional, Luxton, Jared J., additional, Bordman, Aryn, additional, Okuda, Kei, additional, Taylor, Lynn E., additional, Hayes, Josh, additional, Gerke, Hannah C., additional, Chinn, Sarah M., additional, Anderson, Donovan, additional, Laudenslager, Mark L., additional, Takase, Tsugiko, additional, Nemoto, Yui, additional, Ishiniwa, Hiroko, additional, Beasley, James C., additional, and Bailey, Susan M., additional

Published
2021
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47. Ad Astra – telomeres in space!

Author

Bailey, Susan M., primary, Luxton, Jared J., additional, McKenna, Miles J., additional, Taylor, Lynn E., additional, George, Kerry A., additional, Jhavar, Sameer G., additional, and Swanson, Gregory P., additional

Published
2021
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48. Haplotype diversity and sequence heterogeneity of human telomeres

Author

Grigorev, Kirill, primary, Foox, Jonathan, additional, Bezdan, Daniela, additional, Butler, Daniel, additional, Luxton, Jared J., additional, Reed, Jake, additional, McKenna, Miles J., additional, Taylor, Lynn, additional, George, Kerry A., additional, Meydan, Cem, additional, Bailey, Susan M., additional, and Mason, Christopher E., additional

Published
2021
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49. Finding the Collective Voice — the role of family and community in improving housing options for adults with disability

Author

Bailey, Susan M.

Abstract

University of Technology Sydney. Faculty of Design, Architecture and Building. This thesis describes the activities and strategies of parents and not-for-profit non-government organisations (NGOs) to create new homes for adults with disability. Theories of institutional entrepreneurship, social entrepreneurship and social innovation explain the power of families and NGOs to create new homes when traditional housing systems were constrained and government-funded housing was difficult to access. Cross-case comparison of 11 case studies used activity theory to study innovative living arrangements created by combining resources and other inputs from different actors across sectoral boundaries until new homes were attained and adults could live with more independence. Families and NGOs were institutional entrepreneurs, innovators and change agents who created new homes in new ways for adults when housing was a necessity and there was no other way of achieving it. The research contributes to the practice of institutional entrepreneurship, the field of the study of power, the discipline of social entrepreneurship and the application of social innovation in meeting housing needs. Activity theory revealed that the institutions of family, the state and the not-for-profit sector can achieve new models of housing and paid support for adults when they collaborate, combine resources and act together without regard for housing system or sector boundaries.

Published
2021

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