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1. Diagnostic accuracy and confounders of vagus nerve ultrasound in amyotrophic lateral sclerosis—a single-center case series and pooled individual patient data meta-analysis

Author

Müller, Katharina J., Schmidbauer, Moritz L., Schönecker, Sonja, Kamm, Katharina, Pelz, Johann O., Holzapfel, Korbinian, Papadopoulou, Marianna, Bakola, Eleni, Tsivgoulis, Georgios, Naumann, Markus, Hermann, Andreas, Walter, Uwe, Dimitriadis, Konstantinos, Reilich, Peter, and Schöberl, Florian more...

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2024
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3. Performance of Different Risk Scores for the Detection of Atrial Fibrillation Among Patients With Cryptogenic Stroke

Author

Palaiodimou, Lina, Theodorou, Aikaterini, Triantafyllou, Sokratis, Dilaveris, Polychronis, Flevari, Panagiota, Giannopoulos, Georgios, Kossyvakis, Charalampos, Adreanides, Elias, Tympas, Konstantinos, Nikolopoulos, Petros, Zompola, Christina, Bakola, Eleni, Chondrogianni, Maria, Magiorkinis, Gkikas, Deftereos, Spyridon, Giannopoulos, Sotirios, Tsioufis, Konstantinos, Filippatos, Gerasimos, and Tsivgoulis, Georgios more...

Published
2024
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8. Cognitive Impairment in Cerebral Amyloid Angiopathy: A Single-Center Prospective Cohort Study.

Author

Theodorou, Aikaterini, Athanasaki, Athanasia, Melanis, Konstantinos, Pachi, Ioanna, Sterpi, Angeliki, Koropouli, Eleftheria, Bakola, Eleni, Chondrogianni, Maria, Stefanou, Maria-Ioanna, Vasilopoulos, Efthimios, Kouzoupis, Anastasios, Paraskevas, Georgios P., Tsivgoulis, Georgios, and Tzavellas, Elias more...

Subjects
CEREBRAL amyloid angiopathy, MAGNETIC resonance imaging, ALZHEIMER'S disease, TAU proteins, MINI-Mental State Examination
Abstract

Background/Objectives: Cognitive impairment represents a core and prodromal clinical feature of cerebral amyloid angiopathy (CAA). We sought to assess specific cognitive domains which are mainly affected among patients with CAA and to investigate probable associations with neuroimaging markers and Cerebrospinal Fluid (CSF) biomarkers. Methods: Thirty-five patients fulfilling the Boston Criteria v1.5 or v2.0 for the diagnosis of probable/possible CAA were enrolled in this prospective cohort study. Brain Magnetic Resonance Imaging and CSF biomarker data were collected. Every eligible participant underwent a comprehensive neurocognitive assessment. Spearman's rank correlation tests were used to identify possible relationships between the Addenbrooke's Cognitive Examination—Revised (ACE-R) sub-scores and other neurocognitive test scores and the CSF biomarker and neuroimaging parameters among CAA patients. Moreover, linear regression analyses were used to investigate the effects of CSF biomarkers on the ACE-R total score and Mini-Mental State Examination (MMSE) score, based on the outcomes of univariate analyses. Results: Cognitive impairment was detected in 80% of patients, and 60% had a coexistent Alzheimer's disease (AD) pathology based on CSF biomarker profiles. Notable correlations were identified between increased levels of total tau (t-tau) and phosphorylated tau (p-tau) and diminished performance in terms of overall cognitive function, especially memory. In contrast, neuroimaging indicators, including lobar cerebral microbleeds and superficial siderosis, had no significant associations with cognitive scores. Among the CAA patients, those without AD had superior neurocognitive test performance, with significant differences observed in their ACE-R total scores and memory sub-scores. Conclusions: The significance of tauopathy in cognitive impairment associated with CAA may be greater than previously imagined, underscoring the necessity for additional exploration of the non-hemorrhagic facets of the disease and new neuroimaging markers. [ABSTRACT FROM AUTHOR] more...

Published
2024
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9. Collet–Sicard syndrome due to cervical artery dissection disclosed by high‐resolution magnetic resonance imaging.

Author

Theodorou, Aikaterini, Lachanis, Stefanos, Papagiannopoulou, Georgia, Maili, Maria, Pachi, Ioanna, Velonakis, Georgios, Bakola, Eleni, Vassilopoulou, Sofia, and Tsivgoulis, Georgios

Subjects
CAROTID artery dissections, INTERNAL carotid artery, HYPOGLOSSAL nerve, MAGNETIC resonance imaging, CRANIAL nerves, CRANIAL nerve diseases
Abstract

Background and purpose: Cervical artery dissection (CAD) represents a leading cause of unilateral lower cranial nerve IX–XII palsy, known as Collet–Sicard syndrome (CSS). High‐resolution magnetic resonance imaging (HR‐MRI) is widely used in the evaluation of patients with CAD, providing information regarding vessel wall abnormalities and intraluminal thrombus. Methods: We present a patient with palsy of multiple lower cranial nerves in the context of CSS, attributed to unilateral spontaneous internal carotid artery dissection. Results: We describe a 68‐year‐old man with unremarkable previous history, who presented with subacute, gradually worsening dysphagia and hoarse voice. Clinical examination revealed right‐sided palsy of cranial nerves IX–XII. Three‐dimensional fat‐saturated black‐blood T1‐weighted high‐resolution vessel wall imaging disclosed spontaneous dissection with intramural hematoma along the distal right internal carotid artery. Neck MRI showed inward displacement of right aryepiglottic fold, right pyriform sinus dilatation, and right true vocal cord in middle position, indicative of right vagus nerve palsy, atrophy of right trapezius and sternocleidomastoid muscles, due to right spinal accessory nerve palsy, and unilateral tongue atrophy with fatty infiltration, characteristic for right hypoglossal nerve palsy. Conclusions: This case highlights the utility of high‐resolution vessel wall imaging and especially fat‐saturated T1‐weighted black‐blood SPACE (sampling perfection with application‐optimized contrast using different flip‐angle evolutions) sequences in the accurate diagnosis of CAD, revealing the characteristic mural hematoma and intimal flap. HR‐MRI is also valuable in the recognition of indirect signs of lower cranial nerve compression. [ABSTRACT FROM AUTHOR] more...

Published
2024
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10. Symptomatic Unilateral Carotid Artery Disease

Author

Melanis, Konstantinos, primary, Athanasaki, Athanasia, additional, Bakola, Eleni, additional, Chondrogianni, Maria, additional, Lazaris, Andreas, additional, Akrivaki, Alexandra, additional, Triantafyllou, Alexandros Stavros, additional, Kotsali-Peteinelli, Vasiliki, additional, Bonakis, Anastasios, additional, Paraskevas, George P., additional, and Tsivgoulis, Georgios, additional more...

Published
2024
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12. Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes

Author

Marvardi, Michele, primary, Ferrante, Mario, additional, Paciaroni, Maurizio, additional, Abdul-Rahim, Azmil H, additional, Tsivgoulis, Georgios, additional, Seiffge, David J, additional, Engelter, Stefan T, additional, Lyrer, Philippe A., additional, Polymeris, Alexandros A, additional, Dittrich, Tolga D, additional, Cancelloni, Virginia, additional, Zietz, Annaelle, additional, De Marchis, Gian Marco, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Vanacker, Peter, additional, Zuurbier, Susanna M., additional, Yperzeele, Laetitia, additional, Loos, Caroline MJ, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Becattini, Cecilia, additional, Pascarella, Rosario, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra Sharma, additional, Schomer, Ashley, additional, Mac Grory, Brian, additional, Jayaraman, Mahesh V, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne A, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Leone De Magistris, Ilaria, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D'Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Adamou, Anastasia, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, D'agliano, Roberto, additional, Baldini, Marco, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Halvatsiotis, Panagiotis, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, lanari, alessia, additional, Tatlisumak, Turgut, additional, Acciarresi, Monica, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung-Il, additional, Mumoli, Nicola, additional, Cararra, Davide, additional, Maccarrone, Miriam, additional, Galati, Franco, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Corea, Francesco, additional, Bellesini, Marta, additional, Karapanayiotides, Theodore, additional, Csiba, Laszlo, additional, Szabo, Lilla, additional, Imberti, Davide, additional, Pieroni, Alessio, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Doronin, Boris, additional, Volodina, Vera Alexandrovna, additional, Agnelli, Giancarlo, additional, Deleu, Dirk, additional, Bonetti, Bruno, additional, Gentile, Luana, additional, Reale, Giuseppe, additional, Caliandro, Pietro, additional, Morotti, Andrea, additional, Vannucchi, Vieri, additional, Padroni, Marina, additional, Letteri, Federica, additional, Magoni, Mauro, additional, Tiseo, Cindy, additional, Rigatelli, Alberto, additional, Zauli, Aurelia, additional, Bossi, Francesco, additional, and Caso, Valeria, additional more...

Published
2024
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18. Transorbital sonography in idiopathic intracranial hypertension: Single‐center study, systematic review and meta‐analysis

Author

Bakola, Eleni, primary, Palaiodimou, Lina, additional, Eleftheriou, Andreas, additional, Foska, Katerina, additional, Pikouli, Anastasia, additional, Stefanatou, Maria, additional, Chondrogianni, Maria, additional, Velonakis, Georgios, additional, Andreadou, Elissavet, additional, Papadopoulou, Marianna, additional, Karapanayiotides, Theodoros, additional, Krogias, Christos, additional, Arvaniti, Chrysa, additional, and Tsivgoulis, Georgios, additional more...

Published
2023
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20. Icatibant averting mechanical ventilation in acute ischemic stroke patient with alteplase‐induced orolingual angioedema.

Author

Theodorou, Aikaterini, Dimitriadou, Evangelia‐Makrina, Tzanetakos, Dimitrios, Bakola, Eleni, Chondrogianni, Maria, Palaiodimou, Lina, Keramida, Anna, Vassilopoulou, Sofia, Makris, Michael, Paraskevas, Georgios P., and Tsivgoulis, Georgios more...

Subjects
STROKE patients, ARTIFICIAL respiration, ISCHEMIC stroke, ANGIONEUROTIC edema, URTICARIA, ACE inhibitors
Abstract

Background and purpose: Orolingual angioedema (OA) represents a rare but life‐threatening complication among patients with acute ischemic stroke treated with intravenous thrombolysis with alteplase. Novel agents, including icatibant, are recommended in resistant patients with alteplase‐induced OA who have failed to respond to first‐line therapies including corticosteroids, antihistamines, and/or adrenaline. Methods: We present a patient with alteplase‐induced OA who showed substantial clinical improvement following the administration of icatibant. Results: We describe a 71‐year‐old woman with known arterial hypertension under treatment with angiotensin‐converting enzyme inhibitor, who presented with acute ischemic stroke in the territory of the right middle cerebral artery and received intravenous alteplase. During intravenous thrombolysis, the case was complicated with OA without any response to standard anaphylactic treatment including corticosteroids, dimetindene, and adrenaline. Thirty minutes after symptom onset, icatibant, a synthetic selective bradykinin B2‐receptor antagonist, was administered subcutaneously. Substantial symptomatic resolution was observed only following the icatibant administration. Conclusions: This case highlights the effectiveness of icatibant in the acute management of alteplase‐induced OA. In particular, icatibant administration, following first‐line therapies including corticosteroids, antihistamines, and/or adrenaline, may avert tracheostomy and intubation in resistant and refractory cases with OA following intravenous thrombolysis for acute ischemic stroke. [ABSTRACT FROM AUTHOR] more...

Published
2024
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21. Clinical Characteristics, Neuroimaging Markers, and Outcomes in Patients with Cerebral Amyloid Angiopathy: A Prospective Cohort Study

Author

Theodorou, Aikaterini, primary, Palaiodimou, Lina, additional, Papagiannopoulou, Georgia, additional, Kargiotis, Odysseas, additional, Psychogios, Klearchos, additional, Safouris, Apostolos, additional, Bakola, Eleni, additional, Chondrogianni, Maria, additional, Kotsali-Peteinelli, Vasiliki, additional, Melanis, Konstantinos, additional, Tsibonakis, Athanasios, additional, Andreadou, Elissavet, additional, Vasilopoulou, Sofia, additional, Lachanis, Stefanos, additional, Velonakis, Georgios, additional, Tzavellas, Elias, additional, Tzartos, John S., additional, Voumvourakis, Konstantinos, additional, Paraskevas, Georgios P., additional, and Tsivgoulis, Georgios, additional more...

Published
2023
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22. Transorbital sonography in idiopathic intracranial hypertension: Single‐center study, systematic review and meta‐analysis.

Author

Bakola, Eleni, Palaiodimou, Lina, Eleftheriou, Andreas, Foska, Katerina, Pikouli, Anastasia, Stefanatou, Maria, Chondrogianni, Maria, Velonakis, Georgios, Andreadou, Elissavet, Papadopoulou, Marianna, Karapanayiotides, Theodoros, Krogias, Christos, Arvaniti, Chrysa, and Tsivgoulis, Georgios more...

Subjects
*INTRACRANIAL hypertension, *ULTRASONIC imaging, *OPTIC disc, *OPTIC nerve, *NONINVASIVE diagnostic tests, *ODDS ratio, *LIKELIHOOD ratio tests
Abstract

Background and Purpose: Transorbital sonography (TOS) provides a noninvasive tool to detect intracranial pressure by assessing optic nerve sheath diameter (ONSD) and optic disc elevation (ODE). The utility of TOS in the diagnosis of idiopathic intracranial hypertension (IIH) has been increasingly recognized. Methods: A single‐center case‐control study sought to compare TOS‐acquired ONSD and ODE among IIH‐cases versus patients with other neurological diseases (controls). Furthermore, a systematic review and meta‐analysis was conducted to present pooled mean differences and diagnostic measures of ONSD and ODE between IIH‐cases and controls. Results: In the single‐center study, consisting of 31 IIH‐cases and 34 sex‐ and age‐matched controls, ONSD values were higher among IIH‐cases than controls (p<.001), while ODE was more prevalent in cases (65% vs. 15%; p<.001). The receiver‐operating characteristic (ROC)‐curve analysis revealed that the optimal cutoff value of ONSD for predicting IIH was 5.15 mm, with an area under the curve (AUC) of 0.914 (95% confidence interval [CI]: 0.861‐0.967) and sensitivity and specificity values of 85% and 90%, respectively. In a meta‐analysis of 14 included studies with 415 IIH‐cases, ONSD and ODE values were higher in IIH‐cases than controls (mean difference in ONSD 1.20 mm; 95% CI: 0.96‐1.44 mm and in ODE 0.3 mm; 95% CI: 0.33‐0.67 mm). With regard to ONSD, pooled sensitivity, specificity, and diagnostic odds ratio were calculated at 85.5% (95% CI: 77.9‐90.8%), 90.7% (95% CI: 84.6‐94.5%), and 57.394 (95% CI: 24.597‐133.924), respectively. The AUC in summary ROC‐curve analysis was 0.878 (95% CI: 0.858‐0.899) with an optimal cutoff point of 5.0 mm. Conclusions: TOS has a high diagnostic utility for the noninvasive diagnosis of IIH and may deserve wider implementation in everyday clinical practice. [ABSTRACT FROM AUTHOR] more...

Published
2024
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23. Impaired cerebral autoregulation in Fabry disease: A case‐control study

Author

Palaiodimou, Lina, primary, Papagiannopoulou, Georgia, additional, Bakola, Eleni, additional, Papadopoulou, Marianna, additional, Kokotis, Panagiotis, additional, Moschovos, Christos, additional, Vrettou, Agathi‐Rosa, additional, Kapsia, Eleni, additional, Petras, Dimitrios, additional, Anastasakis, Aris, additional, Lionaki, Sophia, additional, Vlachopoulos, Charalambos, additional, Boletis, Ioannis N., additional, Zompola, Christina, additional, and Tsivgoulis, Georgios, additional more...

Published
2023
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24. sj-docx-1-tan-10.1177_17562864231180711 – Supplemental material for Autonomic dysfunction entwined with post-COVID but absent in non-post-COVID patients: a neurophysiological and neurosonology study

Author

Papadopoulou, Marianna, Bakola, Eleni, Papapostolou, Apostolos, Stefanou, Maria-Ioanna, Andreadou, Elisabeth, Zouvelou, Vasiliki, Stefanatou, Maria, Gaga, Mina, Michopoulos, Ioannis, and Tsivgoulis, Georgios more...

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-tan-10.1177_17562864231180711 for Autonomic dysfunction entwined with post-COVID but absent in non-post-COVID patients: a neurophysiological and neurosonology study by Marianna Papadopoulou, Eleni Bakola, Apostolos Papapostolou, Maria-Ioanna Stefanou, Elisabeth Andreadou, Vasiliki Zouvelou, Maria Stefanatou, Mina Gaga, Ioannis Michopoulos and Georgios Tsivgoulis in Therapeutic Advances in Neurological Disorders more...

Published
2023
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25. Churg–Strauss syndrome‐associated heart failure and left ventricular thrombosis

Author

Liori, Sotiria, primary, Samiotis, Eleftherios, additional, Birba, Dionysia, additional, Katsimbri, Pelagia, additional, Mademli, Maria, additional, Bakola, Eleni, additional, Tsivgoulis, Georgios, additional, Quris, Estela, additional, Bonios, Michael, additional, Kalabaliki, Maria, additional, Farmakis, Dimitrios, additional, Parissis, John, additional, and Frogoudaki, Alexandra, additional more...

Published
2023
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27. Cortical Superficial Siderosis and Transient Focal Neurological Episode Preceding Lobar Hemorrhage in Cerebral Amyloid Angiopathy

Author

Theodorou, Aikaterini, primary, Chondrogianni, Maria, additional, Bakola, Eleni, additional, Kaloudi, Georgia, additional, Foska, Aikaterini, additional, Michalakakou, Smaragdi, additional, Melanis, Konstantinos, additional, Paraskevas, Georgios P., additional, and Tsivgoulis, Georgios, additional more...

Published
2023
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28. Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series

Author

Bakola, Eleni, primary, Papagiannopoulou, Georgia, additional, Palaiodimou, Lina, additional, Lagios, Konstantinos, additional, Archontakis, Eftychios, additional, Theodorou, Aikaterini, additional, Katsanos, Aristeidis H., additional, Triantafyllou, Sokratis, additional, Zouvelou, Vasiliki, additional, Lachanis, Stefanos, additional, Tzanetakos, Dimitrios, additional, Tzartos, John S., additional, Giannopoulos, Sotirios, additional, and Tsivgoulis, Georgios, additional more...

Published
2023
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29. Quality metrics in the management of acute stroke in Greece during the first 5 years of Registry of Stroke Care Quality (RES-Q) implementation

Author

Palaiodimou, Lina, primary, Kargiotis, Odysseas, additional, Katsanos, Aristeidis H, additional, Kiamili, Argyro, additional, Bakola, Eleni, additional, Komnos, Apostolos, additional, Zisimopoulou, Vaso, additional, Natsis, Konstantinos, additional, Papagiannopoulou, Georgia, additional, Theodorou, Aikaterini, additional, Zompola, Christina, additional, Safouris, Apostolos, additional, Psychogios, Klearchos, additional, Ntais, Evangelos, additional, Plomaritis, Panagiotis, additional, Karamatzianni, Georgia, additional, Mavriki, Andriana, additional, Koutsokera, Maria, additional, Lykou, Christina, additional, Koutroulou, Ioanna, additional, Gourbali, Vanessa, additional, Skafida, Anastasia, additional, Roussopoulou, Andromachi, additional, Kourtesi, Georgia, additional, Papamichalis, Panagiotis, additional, Papagiannopoulos, Sotirios, additional, Gryllia, Maria, additional, Tavernarakis, Antonios, additional, Kazis, Dimitrios, additional, Karapanayiotides, Theodoros, additional, Magoufis, Georgios, additional, Giannopoulos, Sotirios, additional, and Tsivgoulis, Georgios, additional more...

Published
2023
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31. D313Y Variant in Fabry Disease

Author

Palaiodimou, Lina, primary, Stefanou, Maria-Ioanna, additional, Bakola, Eleni, additional, Papadopoulou, Marianna, additional, Kokotis, Panagiotis, additional, Vrettou, Agathi-Rosa, additional, Kapsia, Eleni, additional, Petras, Dimitrios, additional, Anastasakis, Aris, additional, Xifaras, Nikolaos, additional, Karachaliou, Eleni, additional, Touloumi, Giota, additional, Vlachopoulos, Charalambos, additional, Boletis, Ioannis N., additional, Giannopoulos, Sotirios, additional, Tsivgoulis, Georgios, additional, and Zompola, Christina, additional more...

Published
2022
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32. Telltale Signs of Idiopathic Intracranial Hypertension With Normal Opening Cerebrospinal Fluid Pressure

Author

Foska, Aikaterini, primary, Palaiodimou, Lina, additional, Stefanou, Maria Ioanna, additional, Alonistiotis, Dimitrios, additional, Bakola, Eleni, additional, Papagiannopoulou, Georgia, additional, Arvaniti, Chrysa, additional, Bonakis, Anastasios, additional, Lachanis, Stefanos, additional, and Tsivgoulis, Georgios, additional more...

Published
2022
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33. Acute Arterial Ischemic Stroke Following COVID-19 Vaccination

Author

Stefanou, Maria-Ioanna, primary, Palaiodimou, Lina, additional, Aguiar de Sousa, Diana, additional, Theodorou, Aikaterini, additional, Bakola, Eleni, additional, Katsaros, Dimitrios Eleftherios, additional, Halvatsiotis, Panagiotis, additional, Tzavellas, Elias, additional, Naska, Androniki, additional, Coutinho, Jonathan M., additional, Sandset, Else Charlotte, additional, Giamarellos-Bourboulis, Evangelos J., additional, and Tsivgoulis, Georgios, additional more...

Published
2022
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34. Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study

Author

Paciaroni, Maurizio, primary, Caso, Valeria, additional, Agnelli, Giancarlo, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Seiffge, David Julian, additional, Engelter, Stefan T., additional, Lyrer, Philippe, additional, Polymeris, Alexandros A., additional, Kriemler, Lilian, additional, Zietz, Annaelle, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Remillard, Suzette, additional, Buehrer, Manuela, additional, Bavaud, Odessa, additional, Vanacker, Peter, additional, Zuurbier, Susanna, additional, Yperzeele, Laetitia, additional, Loos, Caroline M.J., additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Abdul-Rahim, Azmil, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra, additional, Reznik, Michael, additional, Schomer, Ashley, additional, Grory, Brian Mac, additional, Jayaraman, Mahesh, additional, McTaggart, Ryan, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Padroni, Marina, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Traballi, Laura, additional, Urbini, Chiara, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Caliandro, Pietro, additional, Zauli, Aurelia, additional, Reale, Giuseppe, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D’Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Tsivgoulis, Georgios, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Denti, Licia, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, Ferrari, Elena, additional, Caselli, Maria Chiara, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, and De Marchis, Gian Marco, additional more...

Published
2022
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35. Guillain-Barré syndrome and fulminant encephalomyelitis following Ad26.COV2.S vaccination: double jeopardy.

Author

Stefanou, Maria Ioanna Karachaliou, Eleni Chondrogianni, Maria Moschovos, Christos Bakola, Eleni Foska, Aikaterini Melanis, Konstantinos Andreadou, Elisabeth Voumvourakis, Konstantinos Papathanasiou, Matilda Boutati, Eleni Tsivgoulis, Georgios and Stefanou, Maria Ioanna Karachaliou, Eleni Chondrogianni, Maria Moschovos, Christos Bakola, Eleni Foska, Aikaterini Melanis, Konstantinos Andreadou, Elisabeth Voumvourakis, Konstantinos Papathanasiou, Matilda Boutati, Eleni Tsivgoulis, Georgios more...

Abstract

This correspondence comments on a published article presenting a case of rhombencephalitis following SARS-CoV-2-vaccination with the mRNA vaccine BNT162b2 (Pfizer/BioNTech). We also present the case of a 47-year-old man who developed Guillain-Barré-syndrome and a fulminant encephalomyelitis 28 days after immunization with Ad26.COV2.S (Janssen/Johnson & Johnson). Based on the presented cases, we underscore the importance of clinical awareness for early recognition of overlapping neuroimmunological syndromes following vaccination against SARS-CoV-2. Additionally, we propose that that role of autoantibodies against angiotensin-converting enzyme 2 (ACE2) and the cell-surface receptor neuropilin-1, which mediate neurological manifestations of SARS-CoV-2, merit further investigation in patients presenting with neurological disorders following vaccination against SARS-CoV-2. more...

Published
2022

37. Classical Cerebrospinal Fluid Biomarkers in Dementia with Lewy Bodies

Author

Foska, Aikaterini, primary, Tsantzali, Ioanna, additional, Sideri, Eleni, additional, Stefanou, Maria Ioanna, additional, Bakola, Eleni, additional, Kitsos, Dimitrios K., additional, Zompola, Christina, additional, Bonakis, Anastasios, additional, Giannopoulos, Sotirios, additional, Voumvourakis, Konstantinos I., additional, Tsivgoulis, Georgios, additional, and Paraskevas, George P., additional more...

Published
2022
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38. Connecting Nature Deliverable 7: Final report of all meetings, consultations, webinars and workshops and the publication of a co-production guidebook for cities consisting of 2 guidebooks: 'A practical guide to using co-production for nature-based solutions' and 'A practical guide to using reflexive monitoring for nature-based solutions' (including infographics)

Author

Hölscher, Katharina, Janssen, Annelli, Lodder, Marleen, van der Have, Carien, Albulescu, Patricia, Allaert, Kato, Bakola, Eleni, Beslagic, Lejla, Boskidis, Ioannis, Collier, Marcus J., Dick, Gillian, Dymek, Dominika, Dziubala, Agnieszka, García-Espina Adank, Christian, González Vazquez, Maria Mercedes, Kelly, Sean, Kindlon, Donnchadh, Madajczyk, Natalia, Malekkidou, Eleni, Mavroudi, Maria, McCann, Shibeal, Osipiuk, Agnieszka, Pašić, Belma, Prieto González, Antonio, Quartier, Mien, Sermpezi, Rania, Sulea, Coralia, Suljevic, Nermina, Trendafilov, Ivaylo, Tsouris, Vasilis, Van De Sijpe, Katrien, Velikova, Vili, Vos, Peter, and Xidous, Dimitra more...

Subjects
Co-production, Connecting Nature Framework, Co-creation, City, Nature-based solutions, Urban, Urban transitioning, Connecting Nature, Fast-follower cities, Reflexive monitoring, Business models, Front-runner cities
Abstract

This Deliverable presents our underlying conceptual and methodological approach as well as analytical results by which we have co-developed co-production and reflexive monitoring methodologies for the planning, delivery and stewardship of nature-based solutions on a large scale in cities. Next to supporting co-production and reflexive monitoring processes on the ground in the Connecting Nature Front-Runner and Fast-Follower Cities, a main aim was to generate systematic insights about how cities go about designing and implementing such novel governance approaches. On the one hand, co-production is booming in cities worldwide as a mode of collaborative governance. By bringing together diverse actors – for example, civil servants, practitioners, social innovators, scientists, entrepreneurs and citizens – co-production can support the generation of transformative nature-based solutions (pertaining not only to their mere technical design but also to their financing and business models and social innovations) addressing local needs and mobilising local opportunities. We developed a comprehensive framework that supports the design, implementation and evaluation of co-production. The framework covers different types of co-production, methods, principles for process design and evaluation as well as capacities for co-production to implement the principles. On the other hand, we developed a reflexive monitoring process to support processes of ongoing learning-by-doing and doing-by-learning. Nature-based solutions planning, delivery and stewardship requires ongoing reflection as well as adaptability to respond to new insights, demands and needs. Our reflexive monitoring methodology consists of a step-wise approach with several process tools that the cities have adapted into their regular activities to create space for reflection and capturing learnings. The recording of learning objectives and outcomes helped the cities structure what opportunities and barriers they have encountered and how they have navigated them, generating insights on critical steps and lessons learned for the design, delivery and stewardship of nature-based solutions. Building on a comparative analysis of the cities, we generated several key lessons about how to adapt and implement co-production and reflexive monitoring: Overall, all cities recognised the value of co-production to engage with and empower diverse actors and reflexive monitoring to facilitate continuous learning and adaptation in real time when planning, delivering and stewarding nature-based solutions. In this way, co-production and reflexive monitoring are able to address the various governance needs for knowledge, partnerships, societal and political support and learning. Adopting new governance processes and tools that challenge conventional practices requires the creation of institutional and organisational space in cities and the acquisition of new skills and knowledge. It also requires new cultures within city governments to work across siloes. Co-production and reflexive monitoring are flexible approaches that need to be made fit to a specific city’s contexts. For example, we could distinguish between various types of co-production processes depending on different goals and settings, including different types of actors and methods. Regarding co-production, it has been challenging to reach out and motivate diverse actors to participate in co- production, including especially vulnerable and low-income communities or specific actors from the business and finance community. This requires dedicated communication and community engagement efforts and skills as well as making the process accessible to different audiences. The value of reflexive monitoring extended to the facilitation of knowledge transfer and peer-to-peer learning between Front-Runner and Fast-Follower Cities. We learned that, from the idea initiation stage, it can take a few years before the cities started implementing their learning outcomes with reflexivity changes. Based on our work with the cities and comparative analysis, we produced conceptually grounded and practice-proven, hands-on guidebooks that help urban practitioners and planners design and implement concrete steps, activities and tools for the co-production and reflexive monitoring of nature-based solutions. We have put in place several mechanisms to ensure the long-term sustainability of our co-production and reflexive monitoring work – in particular, to continue to spread knowledge for example through the OPPLA platform and the UrbanByNature programme., Suggested citation: Hölscher, K., Lodder, M., Janssen, A., van der Have, C., Kindlon, D., McCann, S., Allaert, K., Xidous, D., Albulescu, P., Sulea, C., Prieto Gonzalez, A., Gonzalez Vazquez, M. M., Trendafilov, I., Velikova, V., Van De Sijpe, K., Quartier, M., Vos, P., Dick, G., Kelly, S., Sermpezi, R., Bakola, E., Boskidis, Ioannis; Tsouris, Vasilis; García-Espina Adank, Christian; Malekkidou, Eleni; Mavroudi, M., Osipiuk, A., Dziubala, A., Madajczyk, N., Dymek, D., Pasic, B., Suljevic, N., Beslagic, L., Collier, M. J. (2022). Connecting Nature Deliverable 7: Final report of all meetings, consultations, webinars and workshops and the publication of a co-production guidebook for cities consisting of 2 guidebooks: 'A practical guide to using co-production for nature-based solutions' and 'A practical guide to using reflexive monitoring for nature-based solutions' (including infographics). Project. Brussels: DG Research & Innovation. DOI: https://doi.org/10.5281/zenodo.7443221 more...

Published
2022
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39. Connecting Nature Deliverable 6: Connecting Nature Framework Reports for Fast-follower Cities

Author

Hölscher, Katharina, Allaert, Kato, Janssen, Annelli, Lodder, Marleen, McCann, Shibeal, van der Have, Carien, Asmaryan, Shushanik, Bakola, Eleni, Beslagic, Lejla, Boskidis, Ioannis, Collier, Marcus J., Connop, Stuart, Dick, Gillian, Dumitru, Adina, Dymek, Dominika, Dziubala, Agnieszka, Fletcher , Isobel, García-Espina Adank, Christian, Georgiou, Paulina, Gonzalez Vazquez, Maria Mercedes, Gvilava, Mamuka, Kelly, Sean, Madajczyk, Natalia, Malekkidou, Eleni, Mavroudi, Maria, McQuaid, Siobhán, Osipiuk, Agnieszka, Pasic, Belma, Prieto Gonzalez, Antonio, Quartier, Mien, Rizzi, Daniela, Sermpezi, Rania, Suljevic, Nermina, Tomé Lourido, David, Trendafilov, Ivaylo, Tsouris, Vasilis, Vandergert, Paula, Van De Sijpe, Katrien, Velikova, Vili, Vos, Peter, and Xidous, Dimitra more...

Subjects
Co-creation, Nature-based solutions, Reflexive monitoring
Abstract

The Connecting Nature Framework is a process tool that has been co-produced and co-applied with science and practice partners in the project with the aim to give a hands-on and comprehensive guide to the Connecting Nature cities to develop their nature-based solution exemplars. It places the nature-based solution at the core of an interactive process that distinguishes three phases of development for a nature-based solution: planning, delivery, and stewardship. Throughout each phase, there are seven separate elements that need to be considered: Technical solutions, Governance, Financing and business models, Nature-based entrepreneurship, Co-production, Reflexive monitoring, and Impact assessment. While the first phase of the Framework development and application has focused on three Front-runner Cities (2017- 2019), we have in the second phase (2019-2022) transferred the Framework, including the generated knowledge and insights about how to apply it to different city contexts, to the seven Fast-follower and Multiplier Cities., Suggested citation: Hölscher, K., Allaert, K., Janssen, A., Lodder, M., McCann, S., van der Have, C., Asmaryan, S., Bakola, E., Beslagic, L., Boskidis, I., Collier, M. J., Connop, S., Dick, G., Dumitru, A., Dymek, D., Dziubala, A., Fletcher , I., García-Espina Adank, C., Georgiou, P., Gonzalez Vazquez, M. M., Gvilava, M., Kelly, S., Madajczyk, N., Malekkidou, E., Mavroudi, M., McQuaid, S., Osipiuk, A., Pasic, B., Prieto Gonzalez, A., Quartier, M., Rizzi, D., Sermpezi, R., Suljevic, N., Tomé Lourido, D., Trendafilov, I., Tsouris, V., Vandergert, P., Van De Sijpe, K., Velikova, V., Vos, P., and Xidous, D. (2022). Connecting Nature Deliverable 6: Connecting Nature Framework Reports for Fast-follower Cities. DOI: https://doi.org/10.5281/zenodo.7319263 more...

Published
2022
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40. Connecting Nature Deliverable 14: Report on implementation of Connecting Nature Frameworks in the Fast Follower Cities

Author

Xidous, Dimitra, Prieto Gonzalez, Antonio, Gonzalez Vazquez, Maria Mercedes, Trendafilov, Ivaylo, Velikova, Vili, Boskidis, Ioannis, Tsouris, Vasilis, Bakola, Eleni, García-Espina Adank, Cristian, Malekkidou, Eleni, Mavroudi, Maria, Pasic, Belma, Suljevic, Nermina, Beslagic, Lejla, and Collier, Marcus more...

Abstract

The Connecting Nature Framework places the nature-based solution at the core of an interactive process that runs through three distinct phases of development: planning, delivery, and stewardship. Throughout each phase, there are seven separate elements that cities and other entities may consider to help them shape their individual nature-based solution: Technical solutions, Governance, Financing, and business models, Nature-based enterprises, Co-production, Impact assessment, and Reflexive monitoring. The Connecting Nature Framework has been co-produced by scientific partners and a set of Front- Runner Cities (FRCs) – Genk, Glasgow, and Poznan. The experiences and lessons learned by the FRCs have been transferred to a set of Fast-Follower Cities (FFCs) – A Coruna, Burgas, Ioannina, Malaga, Nicosia, Pavlos Melas, and Sarajevo – via the Experiential Learning Framework (ELF). The ELF has fostered peer-to-peer exchange and collaborative learning across all project activities to support the scaling out of nature-based solutions. This report details the implementation of the Connecting Nature Framework in the FFCs. Generally speaking, the cities have highlighted that the Connecting Nature Framework report and the narrative are useful tools for internal use, as a mechanism to share information on nature-based solutions (NBS). While the cities highlight the challenges with the concept of NbS, each city has reflected on how the use of the Framework has provided opportunities to create conditions for a more integrated approach that the multifunctional aspect of NbS demands. For example, Ioannina’s experience highlights the role of nature-based solutions as positive, proactive tools rather than (just) a response to societal and environmental challenges., Suggested citation: Xidous, D., Bakola, E., Beslagic, L., Boskidis I., García-Espina Adank, C., Gonzalez Vazquez, M. M., Malekkidou, E., Mavroudi, M., Pasic, B., Prieto Gonzalez, A., Suljevic, N., Trendafilov, I., Tsouris, V., Velikova, V. and Collier, M.J. (2022). Report on the implementation of Connecting Nature Frameworks in the Fast Follower Cities: Deliverable 14 of the Connecting Nature Project. DOI: https://doi.org/10.5281/zenodo.7340457 more...

Published
2022
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42. Autonomic dysfunction in amyotrophic lateral sclerosis: A neurophysiological and neurosonology study

Author

Papadopoulou, Marianna, primary, Bakola, Eleni, additional, Papapostolou, Apostolos, additional, Stefanou, Maria Ioanna, additional, Moschovos, Christos, additional, Salakou, Stavroula, additional, Zis, Panagiotis, additional, Zouvelou, Vasiliki, additional, Kimiskidis, Vasilios K., additional, Chroni, Elisabeth, additional, and Tsivgoulis, Georgios, additional more...

Published
2022
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44. Diagnosis and treatment of acute isolated proximal internal carotid artery occlusions: a narrative review

Author

Kargiotis, Odysseas, primary, Psychogios, Klearchos, additional, Safouris, Apostolos, additional, Spiliopoulos, Stavros, additional, Karapanayiotides, Theodore, additional, Bakola, Eleni, additional, Mantatzis, Michail, additional, Dardiotis, Efthimios, additional, Ellul, John, additional, Giannopoulos, Sotirios, additional, Magoufis, Georgios, additional, and Tsivgoulis, Georgios, additional more...

Published
2022
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45. Neurological manifestations of long-COVID syndrome: a narrative review

Author

Stefanou, Maria-Ioanna, primary, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Smyrnis, Nikolaos, additional, Papadopoulou, Marianna, additional, Paraskevas, George P., additional, Rizos, Emmanouil, additional, Boutati, Eleni, additional, Grigoriadis, Nikolaos, additional, Krogias, Christos, additional, Giannopoulos, Sotirios, additional, Tsiodras, Sotirios, additional, Gaga, Mina, additional, and Tsivgoulis, Georgios, additional more...

Published
2022
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47. The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Mosconi, Maria Giulia, Giustozzi, Michela, Tsivgoulis, Georgios, Seiffge, David Julian, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna M., Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Lotti, Enrico Maria, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, De Magistris, Ilaria Leone, Cancelloni, Virginia, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Moci, Marco, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Saggese, Carlo Emanuele, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Morotti, Andrea, Magoni, Mauro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Caselli, Maria Chiara, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Halvatsiotis, Panagiotis, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Baronello, Mario Maimone, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and De Marchis, Gian Marco more...

Abstract

Background: Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading to potential worse outcome, particularly cerebrovascular events. The aims of this study were to calculate the rates of ischemic and severe bleeding events in ischemic stroke patients having both AF and reduced ejection fraction (rEF) (⩽40%), compared to ischemic stroke patients with AF but without rEF.Methods: We performed a retrospective analysis that drew data from prospective studies. The primary outcome was the composite of either ischemic (stroke or systemic embolism), or hemorrhagic events (symptomatic intracranial bleeding and severe extracranial bleeding).Results: The cohort for this analysis comprised 3477 patients with ischemic stroke and AF, of which, 643 (18.3%) had also rEF. After a mean follow-up of 7.5 ± 9.1 months, 375 (10.8%) patients had 382 recorded outcome events, for an annual rate of 18.0%. While the number of primary outcome events in patients with rEF was 86 (13.4%), compared to 289 (10.2%) for the patients without rEF; on multivariable analysis rEF was not associated with the primary outcome (OR 1.25; 95% CI 0.84–1.88). At the end of follow-up, 321 (49.9%) patients with rEF were deceased or disabled (mRS ⩾3), compared with 1145 (40.4%) of those without rEF; on multivariable analysis, rEF was correlated with mortality or disability (OR 1.35; 95% CI 1.03–1.77).Conclusions: In patients with ischemic stroke and AF, the presence of rEF was not associated with the composite outcome of ischemic or hemorrhagic events over short-term follow-up but was associated with increased mortality or disability. more...

Published
2023
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48. Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy

Author

Caliandro, Pietro, Cancelloni, Virginia, Marco, Moci, Reale, Giuseppe, Zauli, Aurelia, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Calabresi, Paolo, Giulia Mosconi, Maria, Giustozzi, Michela, Tsivgoulis, Georgios, Julian Seiffge, David, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Marco De Marchis, Gian, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna, Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil, Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, McTaggart, Ryan, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Maria Lotti, Enrico, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, Leone De Magistris, Ilaria, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Emanuele Saggese, Carlo, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Chiara Caselli, Maria, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Halvatsiotis, Panagiotis, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Poli, Loris, Magoni, Mauro, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Girardi, Laura, Maimone Baronello, Mario, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and Paciaroni, Maurizio more...

Abstract

Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of stroke recurrence despite oral anticoagulation therapy. Patients with cardiovascular comorbidities may take both antiplatelet and oral anticoagulation therapy (OAC/AP). Our study aims to evaluate the safety and efficacy of OAC/AP therapy as secondary prevention in people with AF and ischaemic stroke.Patients and methods: We performed a post-hoc analysis of pooled individual data from multicenter prospective cohort studies and compared outcomes in the OAC/AP cohort and patients on DOAC/VKA anticoagulation alone (OAC cohort). Primary outcome was a composite of ischaemic stroke, systemic embolism, intracranial bleeding, and major extracranial bleeding, while secondary outcomes were ischaemic and haemorrhagic events considered separately. A multivariable logistic regression analysis was performed to identify independent predictors for outcome events. To compare the risk of outcome events between the two cohorts, the relation between the survival function and the set of explanatory variables were calculated by Cox proportional hazard models and the results were reported as adjusted hazard ratios (HR). Finally another analysis was performed to compare the overall risk of outcome events in both OAC/AP and OAC cohorts after propensity score matching (PSM).Results: During a mean follow-up time of 7.5 ± 9.1 months (median follow-up time 3.5 months, interquartile range ±3), 2284 stroke patients were on oral anticoagulants and 215 were on combined therapy. The multivariable model demonstrated that the composite outcome is associated with age (OR: 1.03, 95% CI: 1.01–1.04 for each year increase) and concomitant antiplatelet therapy (OR: 2.2, 95% CI: 1.48–3.27), the ischaemic outcome with congestive heart failure (OR: 1.55, 95% CI: 1.02–2.36) and concomitant antiplatelet therapy (OR: 1.93, 95% CI: 1.19–3.13) and the haemorrhagic outcome with age (OR: 1.03, 95% CI: 1.01–1.06 for each year increase), alcoholism (OR: 2.15, 95% CI: 1.06–4.39) and concomitant antiplatelet therapy (OR: 2.22, 95% CI: 1.23–4.02). Cox regression demonstrated a higher rate of the composite outcome (hazard ratio of 1.93 [95% CI, 1.35–2.76]), ischaemic events (HR: 2.05 [95% CI: 1.45–2.87]) and bleeding outcomes (HR: 1.90 [95% CI, 1.06–3.40]) in OAC/AP cohort. After PSM analysis, the composite outcome remained more frequent in people treated with OAC + AP (RR: 1.70 [95% CI, 1.05–2.74]).Discussion: Secondary prevention with combination of oral anticoagulant and antiplatelet therapy after ischaemic stroke was associated with worse outcomes in our cohort.Conclusion: Further research is needed to improve secondary prevention by investigating the mechanisms of recurrent ischaemic stroke in patients with atrial fibrillation. more...

Published
2023
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50. The Emerging Clinical Utility of Neurosonology During COVID-19 Pandemic

Author

Bakola, Eleni, primary, Kargiotis, Odysseas, additional, Psychogios, Klearchos, additional, Safouris, Apostolos, additional, Palaiodimou, Lina, additional, Stefanou, Maria-Ioanna, additional, Chondrogianni, Maria, additional, Karapanayiotides, Theodoros, additional, Vadikolias, Konstantinos, additional, Krogias, Christos, additional, Giannopoulos, Sotirios, additional, and Tsivgoulis, Georgios, additional more...

Published
2021
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