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5. GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1

Author

Balazova, Lucia, Balaz, Miroslav, Horvath, Carla, Horváth, Áron, Moser, Caroline, Kovanicova, Zuzana, Ghosh, Adhideb, Ghoshdastider, Umesh, Efthymiou, Vissarion, Kiehlmann, Elke, Sun, Wenfei, Dong, Hua, Ding, Lianggong, Amri, Ez-Zoubir, Nuutila, Pirjo, Virtanen, Kirsi A., Niemi, Tarja, Ukropcova, Barbara, Ukropec, Jozef, Pelczar, Pawel, Lamla, Thorsten, Hamilton, Bradford, Neubauer, Heike, and Wolfrum, Christian

Published
2021
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8. Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Author

Sun, Wenfei, Dong, Hua, Becker, Anton S., Dapito, Dianne H., Modica, Salvatore, Grandl, Gerald, Opitz, Lennart, Efthymiou, Vissarion, Straub, Leon G., Sarker, Gitalee, Balaz, Miroslav, Balazova, Lucia, Perdikari, Aliki, Kiehlmann, Elke, Bacanovic, Sara, Zellweger, Caroline, Peleg-Raibstein, Daria, Pelczar, Pawel, Reik, Wolf, Burger, Irene A., von Meyenn, Ferdinand, and Wolfrum, Christian

Published
2018
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11. Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Author

Sun, Wenfei, Dong, Hua, Becker, Anton S., Dapito, Dianne H., Modica, Salvatore, Grandl, Gerald, Opitz, Lennart, Efthymiou, Vissarion, Straub, Leon G., Sarker, Gitalee, Balaz, Miroslav, Balazova, Lucia, Perdikari, Aliki, Kiehlmann, Elke, Bacanovic, Sara, Zellweger, Caroline, Peleg-Raibstein, Daria, Pelczar, Pawel, Reik, Wolf, Burger, Irene A., von Meyenn, Ferdinand, and Wolfrum, Christian

Published
2018
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12. Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Author

Sun, Wenfei, Dong, Hua, Becker, Anton S., Dapito, Dianne H., Modica, Salvatore, Grandl, Gerald, Opitz, Lennart, Efthymiou, Vissarion, Straub, Leon G., Sarker, Gitalee, Balaz, Miroslav, Balazova, Lucia, Perdikari, Aliki, Kiehlmann, Elke, Bacanovic, Sara, Zellweger, Caroline, Peleg-Raibstein, Daria, Pelczar, Pawel, Reik, Wolf, Burger, Irene A., von Meyenn, Ferdinand, and Wolfrum, Christian

Published
2018
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13. Mitochondrial transformation occurs in cultured adipocytes, but fails to increase adipose tissue metabolic activity in mice in vivo

Author

Balazova, Lucia, Palesova, Natalia, and Balaz, Miroslav

Abstract

ABSTRACTA large number of studies in recent years have aimed to devise novel therapeutic strategies to increase adipose tissue metabolic activity and fight the global obesity epidemics. Growing evidence suggests that cells are able to accept isolated mitochondria by a simple coincubation in a process known as mitochondrial transformation. Therefore, we aimed to test whether mitochondrial transformation occurs in mature adipocytes, and whether this phenomenon could be utilized as a therapeutic approach to increase adipose tissue mitochondrial content and improve metabolic control. We provide evidence that both brown and white adipocytes are able to rapidly accept a large amount of brown adipocyte-derived mitochondria, which remain functional for several days and significantly contribute to cellular respiration in vitro. However, we did not find any evidence that internalization of exogenous mitochondria would trigger transcriptional changes in the recipient cells. Moreover, injection of a large amount of brown adipocyte-derived mitochondria into the inguinal fat of C57BL/6 mice failed to increase whole-body energy expenditure, and reduce body weight gain under obesogenic conditions. This might be due to activation of immune response and rapid removal of administered mitochondria. Altogether, our study adds information on the usability of mitochondrial transformation in the treatment of metabolic disease.

Published
2022
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16. A framework for remission in SLE: Consensus findings from a large international task force on definitions of remission in SLE (DORIS).

Author

Tincani A., Voskuyl A., Bertsias G., Aranow C., Aringer M., Arnaud L., Askanase A., Balazova P., Bonfa E., Bootsma H., Boumpas D., Bruce I., Cervera R., Clarke A., Coney C., Costedoat-Chalumeau N., Czirjak L., Rekvig O.P., Rovensky J., Shoenfeld Y., Smolen J., Van Vollenhoven R., Urowitz M., Van Leeuw B., Vasconcelos C., Voss A., Werth V.P., Zakharova H., Zoma A., Schneider M., Ward M., Derksen R., Doria A., Dorner T., Fischer-Betz R., Fritsch-Stork R., Gordon C., Graninger W., Gyori N., Houssiau F., Isenberg D., Jacobsen S., Jayne D., Kuhn A., Le Guern V., Lerstrom K., Levy R., MacHado-Ribeiro F., Mariette X., Missaykeh J., Morand E., Mosca M., Inanc M., Navarra S., Neumann I., Olesinska M., Petri M., Rahman A., Tincani A., Voskuyl A., Bertsias G., Aranow C., Aringer M., Arnaud L., Askanase A., Balazova P., Bonfa E., Bootsma H., Boumpas D., Bruce I., Cervera R., Clarke A., Coney C., Costedoat-Chalumeau N., Czirjak L., Rekvig O.P., Rovensky J., Shoenfeld Y., Smolen J., Van Vollenhoven R., Urowitz M., Van Leeuw B., Vasconcelos C., Voss A., Werth V.P., Zakharova H., Zoma A., Schneider M., Ward M., Derksen R., Doria A., Dorner T., Fischer-Betz R., Fritsch-Stork R., Gordon C., Graninger W., Gyori N., Houssiau F., Isenberg D., Jacobsen S., Jayne D., Kuhn A., Le Guern V., Lerstrom K., Levy R., MacHado-Ribeiro F., Mariette X., Missaykeh J., Morand E., Mosca M., Inanc M., Navarra S., Neumann I., Olesinska M., Petri M., and Rahman A.

Abstract

Objectives Treat-to-target recommendations have identified 'remission' as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE. Methods An international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%. Results The task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions: 1. Definitions of remission will be worded as follows: remission in SLE is a durable state characterised by ...................... (reference to symptoms, signs, routine labs). 2. For defining remission, a validated index must be used, for example, clinical systemic lupus erythematosus disease activity index (SLEDAI)=0, British Isles lupus assessment group (BILAG) 2004 D/E only, clinical European consensus lupus outcome measure (ECLAM)=0; with routine laboratory assessments included, and supplemented with physician's global assessment. 3. Distinction is made between remission off and on therapy: remission off therapy requires the patient to be on no other treatment for SLE than maintenance antimalarials; and remission on therapy allows patients to be on stable maintenance antimalarials, low-dose corticosteroids (prednisone <=5 mg/day), maintenance immunosuppressives and/or maintenance biologics. The task force also agreed that the most appropriate outcomes (dependent variables) for testing the prognostic value (construct validity) of potential remission definitions are: death, damage, flares and measures of health-related quality of life. Conclusions The work of this international task force provides a framework for testing different definitions of remission against long-term outcomes.Copyright © Publish

Published
2017

19. Paul Felix Lazarsfeld His Methodological Inspirations and Networking Activities in the Field of Social Research, Prague, 25 - 27 September 2011.

Author

Balazova, Eva and Marsalek, Jan

Subjects
INSPIRATION, METHODOLOGY, SOCIAL networks, CONFERENCES & conventions
Abstract

This short text informs about the international conference dedicated to the life and work of Paul F. Lazarsfeld which was held in Prague, September 2011. It organizes the conference presentations into three blocks: 1) Critical analyses of social research methods that Lazarsfeld propagated; 2) Commemorations of his personality and intellectual style; 3) Studies of Lazarsfeld’s posterity and of his presence in current social research. [ABSTRACT FROM PUBLISHER]

Published
2012
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20. Cardiac Output by Flotrac/VigileoTM Validation Trials: Are there Reliable Conclusions?

Author

Giustiniano, Enrico, Morenghi, Emanuela, Ruggieri, Nadia, Pellegrino, Francesco, Balazova, Jana, Dominoni, Cristina, and Marinelli, Gian

Abstract

We reviewed the comparative trials of the Flotrac/VigileoTM versus the thermodilution method, published in the last five years. The results about the agreement between the two methods measuring cardiac output are contrasting. We also noticed that almost the whole pertinent literature include studies conducted without a correct statistical design, particularly about the sample size. For this reason we consider that results of the published studies about the agreement between pulse contour analysis for cardiac output measurement and thermodilution method may be not reliable.

Published
2012

23. Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.

Author

Balaz, Miroslav, Becker, Anton S., Balazova, Lucia, Straub, Leon, Müller, Julian, Gashi, Gani, Maushart, Claudia Irene, Sun, Wenfei, Dong, Hua, Moser, Caroline, Horvath, Carla, Efthymiou, Vissarion, Rachamin, Yael, Modica, Salvatore, Zellweger, Caroline, Bacanovic, Sara, Stefanicka, Patrik, Varga, Lukas, Ukropcova, Barbara, and Profant, Milan

Abstract

Summary Recent research focusing on brown adipose tissue (BAT) function emphasizes its importance in systemic metabolic homeostasis. We show here that genetic and pharmacological inhibition of the mevalonate pathway leads to reduced human and mouse brown adipocyte function in vitro and impaired adipose tissue browning in vivo. A retrospective analysis of a large patient cohort suggests an inverse correlation between statin use and active BAT in humans, while we show in a prospective clinical trial that fluvastatin reduces thermogenic gene expression in human BAT. We identify geranylgeranyl pyrophosphate as the key mevalonate pathway intermediate driving adipocyte browning in vitro and in vivo , whose effects are mediated by geranylgeranyltransferases (GGTases), enzymes catalyzing geranylgeranylation of small GTP-binding proteins, thereby regulating YAP1/TAZ signaling through F-actin modulation. Conversely, adipocyte-specific ablation of GGTase I leads to impaired adipocyte browning, reduced energy expenditure, and glucose intolerance under obesogenic conditions, highlighting the importance of this pathway in modulating brown adipocyte functionality and systemic metabolism. Graphical Abstract Highlights • The mevalonate pathway is important for adipose tissue browning in mouse and human • Statin use is inversely correlated with brown fat activity in humans • Geranylgeranylation of small GTP-binding proteins promotes adipocyte browning • Small GTP-binding proteins regulate F-actin formation and YAP1/TAZ stability Through genetic and pharmacological in vivo and in vitro approaches, Balaz et al. show that the mevalonate pathway is important for adipocyte browning. The importance of this pathway is supported by a retrospective clinical study and a small volunteer trial with fluvastatin. The authors identify geranylgeranyl pyrophosphate as the key mevalonate intermediate driving adipocyte browning. [ABSTRACT FROM AUTHOR]

Published
2019
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24. BATLAS: Deconvoluting Brown Adipose Tissue

Author

Perdikari, Aliki, Leparc, Germán Gastón, Balaz, Miroslav, Pires, Nuno D., Lidell, Martin E., Sun, Wenfei, Fernandez-Albert, Francesc, Müller, Sebastian, Akchiche, Nassila, Dong, Hua, Balazova, Lucia, Opitz, Lennart, Röder, Eva, Klein, Holger, Stefanicka, Patrik, Varga, Lukas, Nuutila, Pirjo, Virtanen, Kirsi A., Niemi, Tarja, Taittonen, Markku, Rudofsky, Gottfried, Ukropec, Jozef, Enerbäck, Sven, Stupka, Elia, Neubauer, Heike, and Wolfrum, Christian

Abstract

Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies. Here, we provide an in-depth analysis of pure brown, brite, and white adipocyte transcriptomes. By combining mouse and human transcriptome data, we identify a gene signature that can classify brown and white adipocytes in mice and men. Using a machine-learning-based cell deconvolution approach, we develop an algorithm proficient in calculating the brown adipocyte content in complex human and mouse biopsies. Applying this algorithm, we can show in a human weight loss study that brown adipose tissue (BAT) content is associated with energy expenditure and the propensity to lose weight. This online available tool can be used for in-depth characterization of complex adipose tissue samples and may support the development of therapeutic strategies to increase energy expenditure in humans.

Published
2018
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