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6. Beta talasemi minör ve demir eksikliği anemisinin ayırıcı tanısında eritrosit indekslerinin tanısal doğruluk testlerinin değerlendirilmesi: ön çalışma raporu.

Author

Balcı, Tevfik, Ayan, Durmuş, Türkyürek, Cevdet, and Yaylagül, Ergül

Subjects
*IRON deficiency anemia, *BLOOD cell count, *BETA-Thalassemia, *THALASSEMIA, *DIFFERENTIAL diagnosis
Abstract

Purpose: The most common anemias are iron deficiency anemia (IDA) and beta-thalassemia minor (BTm). A correct differantiation of them is important in terms of preventing unnecessary iron treatment and also preventing thalassemia disease. Considering the financial limitations specifically in countries with high prevalence of thalassemia, mathematical indices, which are simpler solutions, have been used to achieve a differential diagnosis. Materials and Methods: Total of 71 cases eligible for inclusion criteria were included in the study and 11 indices were examined. 46 of the cases were in the BTm-group and 25 of the cases were in the IDA-group. The BTmgroup were accepted as positive-patient-group and the IDA-group were accepted as control-group. Diagnostic criteria were evaluated with erythrocyte indices. Results: The highest Youden Index was seen in the Sirdah index (89.48%), followed by two identical performances of the Ehsani and the Mentzer indices (84.%), indicating that these three indices showed the best diagnostic performance. There were two indices with a low performance (DOR<10): The Bessmann and Ricerca indices. Conclusion: Adding appropriate indices to complete blood count (CBC) results before further examinations will be beneficial in terms of efficient use of resources. [ABSTRACT FROM AUTHOR]

Published
2021
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7. Poster Presentations

Author

Önder, Arif, primary, Adanır, Aslı Sürer, additional, Bilaç, Öznur, additional, Kavurma, Canem, additional, Doğan, Yakup, additional, Sapmaz, Şermin Yalın, additional, Türkmen, Nurcan Bektaş, additional, Tekeş, Feyza Alyu, additional, Arslan, Rana, additional, Kurtses Gürsoy, Betül, additional, Öztürk, Büşra, additional, Işıldar, Yetiş, additional, Uzunoğlu, Gülçin Bölük, additional, Bilgen, Nuran, additional, Doğan, Bilge, additional, Duman, Ali, additional, Memiş, Çağdaş Öykü, additional, Kocabaş, Oktay, additional, Sevinçok, Levent, additional, Üçel, Umut İrfan, additional, Demir Özkay, Ümide, additional, Can, Özgür Devrim, additional, Akpınar, Kemal, additional, Özdel, Osman İsmail, additional, Bora, Sultan Taş, additional, Buldukoğlu, Kadriye, additional, Karatoprak, Serdar, additional, Dönmez, Yunus Emre, additional, Özcan, Özlem, additional, Altun, Hatice, additional, Altun, İdiris, additional, Ardic, Ferhat Can, additional, Kose, Samet, additional, Solmaz, Mustafa, additional, Kulacaoglu, Filiz, additional, Balcioglu, Yasin Hasan, additional, Olğar, Yusuf, additional, Turan, Belma, additional, Öztürk, Yusuf, additional, Gelegen, Volkan, additional, Tamam, Lut, additional, Aslan, Şerife, additional, Çamlı, Nevzat, additional, Topak, Osman Zülkif, additional, Tümkaya, Selim, additional, Ateşci, Figen Çulha, additional, Metin, Ozge, additional, Ray, Perihan Cam, additional, Kaypakli, Gamze Yapca, additional, Eynalli, Ezgi, additional, Tahiroglu, Aysegul Yolga, additional, Karci, Canan Kuygun, additional, Celik, Gonca Gul, additional, Çimik, Alper, additional, Alyu, Feyza, additional, Zıblak, Alper, additional, Kenar, Ayşe Nur İnci, additional, Yücel, Nazlı Turan, additional, Barbaros, Mustafa Burak, additional, Eker, Dilan, additional, Çimen, Esen, additional, Gündoğmuş, İbrahim, additional, Algül, Ayhan, additional, Karagöz, Abdulkadir, additional, Kıyançiçek, Murat, additional, Kalcı, Pelin, additional, Karaş, Hakan, additional, Polat, Aslıhan, additional, Alğan, Zehra, additional, İbiloğlu, Aslıhan Okan, additional, İbiloglu, İbrahim, additional, Aslaner, Dilek, additional, Comlekci, Mevlut, additional, Sagir, Selim, additional, Basoglu, Tuba, additional, Özen, Murat Eren, additional, Örüm, Mehmet Hamdi, additional, Kalenderoğlu, Aysun, additional, Peltek, Gülümser, additional, Selek, Salih, additional, Atmaca, Murad, additional, Vural, Mehmet, additional, Aydın, Halef, additional, Yılmaz, Sedat, additional, Öner, Ramazan İlyas, additional, Karadağ, Ayşe Sevgi, additional, Kara, Mahmut Zabit, additional, Usta, Miraç Barış, additional, Karabekiroğlu, Koray, additional, Şahin, Berkan, additional, Aydın, Muazzez, additional, Bozkurt, Abdullah, additional, Karaosman, Tolga, additional, Aral, Armağan, additional, Çobanoğlu, Cansu, additional, Kurt, Ayşegül Duman, additional, Kesim, Neriman, additional, Şahin, İrem, additional, Ürer, Emre, additional, Eğilmez, Oğuzhan Bekir, additional, Utkan, Tijen, additional, Sahin, Tugce Demirtas, additional, Gocmez, Semil Selcen, additional, Yazir, Yusufhan, additional, Aricioglu, Feyza, additional, Yurtdaş, Cangül, additional, Zortul, Hacer, additional, Yilmaz, Bayram, additional, Arıcıoğlu, Feyza, additional, Parlaktaş, Hatice Kübra, additional, Uçar, Aylin Yaba, additional, Yılmaz, Bayram, additional, Kurtul, Neslihan, additional, Arıcı, Asiye, additional, Yazar, Ece Merve, additional, Uzun, Necati, additional, Akça, Ömer Faruk, additional, Kılınç, İbrahim, additional, Balcı, Tevfik, additional, Bayru, Ozge, additional, Bertizlioğlu, Osman, additional, Yalçın, Funda Yiğit, additional, Bolu, Abdullah, additional, Akar, Hatice, additional, Aydın, Mehmet Sinan, additional, Doruk, Ali, additional, Mutu, Tuğba, additional, Yazici, Esra, additional, Guzel, Derya, additional, Erol, Atila, additional, Çiftçi, Elvan, additional, Kaya, Heysem, additional, Güleç, Hüseyin, additional, Salah, Albert Ali, additional, Kalyoncu, Tuğba, additional, Çıldır, Deniz Argüz, additional, Ergüvendi, Fazilet, additional, Shamkhalova, Ulkar, additional, Gok, Ezgi Eynallı, additional, Altunbasak, Sakir, additional, Dogankoc, Seyda Besen, additional, Ovetti, Nefise Hilal Cansever, additional, Metin, Özge, additional, and Shamkhalova, Ulkhar, additional

Published
2018
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8. Bir Üniversite Hastanesinde Hemoglobinopati ve Talasemi Verilerinin Değerlendirilmesi

Author

Özer, Nejla, Uysal, Saliha, Güngören, Merve Sibel, Aköz, Mehmet, Balcı, Tevfik, Saliha Uysal: 0000-0002-9815-1039, Mehmet Aköz: 0000-0003-2748-5493, Tevfik Balcı: 0000-0001-6212-0444, Merve Sibel Güngören: 0000-0002-0203-981X, and Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, Temel Tıp Bilimleri BölümüTıbbi Biyokimya Anabilim Dalı

Subjects
Talasemi, Hemoglobinopati prevalansı, Tertiary referral hospital, Biyokimya ve Moleküler Biyoloji, Thalassemia, Üniversite hastanesi, Hemoglobinopathy prevalance, Üçüncü basamak hastane, University Hospital
Abstract

Amaç: Hemoglobinopatiler, globin fonksiyonlarını bozan bir grup hastalıktır. HPLC, hemoglobinopati taramalarında tüm dünyada en sık kullanılan tekniktir. Çalışmada, Türkiye'de bir üçüncü basamak hastane laboratuvarında 3 yıllık retrospektif hemoglobinopati sıklığı değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Üniversite hastanemize başvuran 2461 hastanın 3 yıllık laboratuvar ve hastane kayıtları incelenmiştir. Hemoglobinopati taramasında Tosoh G8 HPLC cihazı kullanılmıştır Bulgular: HbA2%3,5 olan 668, %3,5HbA2%4 olan 19 sonuç saptanmıştır.19 sonuçtan 10'u betatalasemi minör olarak kabul edilmiştir. HbA2 %4 olan 649 sonuç vardır ve sonculara göre 602 hasta beta-talassemi minör olarak kabul edilmiştir. HbA2 düzeylerine göre, hastaların %25'i beta-talasemi minör olarak değerlendirilmiştir. HbF%2 olan 391 hasta saptanmış ve HbA2%3,5 olan 138 kayıt ayrıntılı incelemeye alınmıştır. Varyant analizi veri kümesi, 53 hasta içermektedir. HbA2%3,5 ve HbF%2 olan, varyant pikleri mevcut kayıtlar incelenmiş ve 28 vaka saptanmıştır. En sık görülen Hb varyantları sırasıyla HbH, HbS, HbD, HbC, HbE ve HbO-Arab'dır. Sonuç: Çalışmada en sık varyantlar sırasıyla HbH, HbAS, HbAD, HbAC, HbAE ve HbO-Arab olarak bulunmuştur. Beta talasemi minör sıklığı ülkemizin gelen popülasyonundan yüksek olarak %25 bulunmuştur. Özellikle hematolojik malignensiler, herediter sferositoz ve demir eksikliği anemisi gibi eşlik eden durumlar hemoglobinopati değerlendirmesinde akılda tutulmalıdır., Objective: Hemoglobinopathies are an array of disorders that affect hemoglobin (Hb) function. HPLC is by far the most common technique used for detection of hemoglobinopathies worldwide. The aim of this study is to evaluate 3-year retrospective data of a tertiary hospital in Turkey according to prevalence of hemoglobinopathies. Material and Methods: A three-year data of 2461 patients admitted to our university hospital laboratory were assessed by scanning laboratory and hospital records. Tosoh G8 HPLC instrument was used for screening. Results: 668 results with HbA23.5% and 19 results with 3.5% HbA2 4% were detected. 10 of 19 patients were considered as beta-thalassemia. Number of patients with HbA2 4% were 649 and 602 of them were assessed as beta-thalassemia-minor. 25% of patients were assessed as beta-thalassemiaminor, based on HbA2 levels. 391 patient results were found to be HbF2% and 138 of them with HbA23.5% were further investigated. Variant analysis dataset contains 53 patients. Samples with HbA23.5% and HbF2% showing variant peaks were scanned and 28 cases were detected. The most common variants were found to be HbH, HbS, HbD, HbC, HbE and HbO-Arab, respectively. Conclusion: In this study, the most common variants were found to be HbH, HbAS, HbAD, HbAC, HbAE and HbO-Arab, respectively. Moreover, the frequency of beta-thalassemia minor was found as 25% which is higher than general population prevalence of our country. Accompanying diseases especially hematological malignancies, hereditary spherocytosis and IDA should be kept in mind during evaluating hemoglobinopathy analysis.

Published
2017

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