164 results on '"Baldasso P"'
Search Results
2. On the algebraic lower bound for the radius of spatial analyticity for the Zakharov-Kuznetsov and modified Zakharov-Kuznetsov equations
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Baldasso, Mikaela and Panthee, Mahendra
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Mathematics - Analysis of PDEs ,35A20, 35B40, 35Q35, 35Q53 - Abstract
We consider the initial value problem (IVP) for the 2D generalized Zakharov-Kuznetsov (ZK) equation \begin{equation} \begin{cases} \partial_{t}u+\partial_{x}\Delta u+\mu \partial_{x}u^{k+1}=0, \,\;\; (x, y) \in \mathbb{R}^2, \, t \in \mathbb{R},\\ u(x,y,0)=u_0(x,y), \end{cases} \end{equation} where $\Delta=\partial_x^2+\partial_y^2$, $\mu=\pm 1$, $k=1,2$ and the initial data $u_0$ is real analytic in a strip around the $x$-axis of the complex plane and have radius of spatial analyticity $\sigma_0$. For both $k=1$ and $k=2$ we prove that there exists $T_0>0$ such that the radius of spatial analyticity of the solution remains the same in the time interval $[-T_0, T_0]$. We also consider the evolution of the radius of spatial analyticity when the local solution extends globally in time. For the Zakharov-Kuznetsov equation ($k=1$), we prove that, in both focusing ($\mu=1$) and defocusing ($\mu=-1$) cases, and for any $T> T_0$, the radius of analyticity cannot decay faster than $cT^{-4+\epsilon}$, $\epsilon>0$, $c>0$. For the modified Zakharov-Kuznetsov equation ($k=2)$ in the defocusing case ($\mu=-1$), we prove that the radius of spatial analyticity cannot decay faster than $cT^{-\frac{4}{3}}$, $c>0$, for any $T>T_0$. These results on the algebraic lower bounds for the evolution of the radius of analyticity improve the ones obtained by Shan and Zhang in [J. Math. Anal. Appl., 501 (2021) 125218] and by Quian and Shan in [Nonlinear Analysis, 235 (2023) 113344] where the authors have obtained lower bounds involving exponential decay., Comment: 34 pages. arXiv admin note: text overlap with arXiv:2308.08541
- Published
- 2024
3. Marked random graphs with given degree sequence: large deviations on the local topology
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Baldasso, Rangel, Pereira, Alan, and Reis, Guilherme
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Mathematics - Probability ,60F10, 05C80 - Abstract
We investigate the behavior of the empirical neighbourhood distribution of marked graphs in the framework of local weak convergence. We establish a large deviation principle for such families of empirical measures. The proof builds on Bordenave and Caputo's seminal 2015 paper, and Delgosha and Anantharam's 2019 introduction of BC entropy, relying on combinatorial lemmas that allow one to construct suitable approximations of measures supported on marked trees.
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- 2023
4. Diving into the proteomic atlas of SARS-CoV-2 infected cells
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Carregari, Victor C., Reis-de-Oliveira, Guilherme, Crunfli, Fernanda, Smith, Bradley J., de Souza, Gabriela Fabiano, Muraro, Stéfanie Primon, Saia-Cereda, Veronica M., Vendramini, Pedro H., Baldasso, Paulo A., Silva-Costa, Lícia C., Zuccoli, Giuliana S., Brandão-Teles, Caroline, Antunes, André, Valença, Aline F., Davanzo, Gustavo G., Virgillio-da-Silva, João Victor, dos Reis Araújo, Thiago, Guimarães, Raphael Campos, Chaim, Felipe David Mendonça, Chaim, Elinton Adami, Kawagosi Onodera, Carolina Mie, Ludwig, Raissa Guimarães, Saccon, Tatiana Dandolini, Damásio, André R. L., Leiria, Luiz Osório S., Vinolo, Marco Aurélio R., Farias, Alessandro S., Moraes-Vieira, Pedro M., Mori, Marcelo A., Módena, José Luiz P., and Martins-de-Souza, Daniel
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- 2024
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5. Improved algebraic lower bound for the radius of spatial analyticity for the generalized KdV equation
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Baldasso, Mikaela and Panthee, Mahendra
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Mathematics - Analysis of PDEs ,35A20, 35B40, 35Q35, 35Q53 - Abstract
We consider the initial value problema (IVP) for the generalized Korteweg-de Vries (gKdV) equation \begin{equation} \begin{cases} \partial_tu+\partial_x^3u+\mu u^k\partial_xu=0, \,\;\; x\in \mathbb{R}, \, t \in \mathbb{R},\\ u(x,0)=u_0(x), \end{cases} \end{equation} where $u(x,\,t)$ is a real valued function, $u_0(x)$ is a real analytic function, $\mu=\pm 1$ and $k\geq 4$. We prove that if the initial data $u_0$ has radius of analyticity $\sigma_0$, then there exists $T_0>0$ such that the radius of spatial analyticity of the solution remains the same in the time interval $[-T_0, \, T_0]$. In the defocusing case, for $k\geq 4$ even, we prove that when the local solution extends globally in time, then for any $T\geq T_0$, the radius of analyticity cannot decay faster than $cT^{-\left(\frac{2k}{k+4}+\epsilon\right)}$, $\epsilon>0$ arbitrarily small and $c>0$ a constant. The result of this work improves the one obtained by Bona et al. in [ J. L. Bona, Z. Gruji\'c, H. Kalisch, Algebraic lower bounds for the uniform radius of spatial analyticity for the generalized KdV equation, Ann Inst. H. Poincar\'e, 22 (2005) 783--797]., Comment: 15 pages
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- 2023
6. Fluctuation bounds for symmetric random walks on dynamic environments via Russo-Seymour-Welsh
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Baldasso, Rangel, Hilario, Marcelo R., Kious, Daniel, and Teixeira, Augusto
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Mathematics - Probability ,60K37 - Abstract
In this article, we prove a lower bound for the fluctuations of symmetric random walks on dynamic random environments in dimension $1 + 1$ in the perturbative regime where the walker is weakly influenced by the environment. We suppose that the random environment is invariant with respect to translations and reflections, satisfies the FKG inequality and a mild mixing condition. The techniques employed are inspired by percolation theory, including a Russo-Seymour-Welsh (RSW) inequality. To exemplify the generality of our results, we provide two families of fields that satisfy our hypotheses: a class of Gaussian fields and Confetti percolation models.
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- 2023
7. Discordant edges for the voter model on regular random graphs
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Avena, Luca, Baldasso, Rangel, Hazra, Rajat Subhra, Hollander, Frank den, and Quattropani, Matteo
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Mathematics - Probability ,05C81, 60K35 - Abstract
We consider the two-opinion voter model on a regular random graph with n vertices and degree $d \geq 3$. It is known that consensus is reached on time scale n and that on this time scale the volume of the set of vertices with one opinion evolves as a Fisher-Wright diffusion. We are interested in the evolution of the number of discordant edges (i.e., edges linking vertices with different opinions), which can be thought as the perimeter of the set of vertices with one opinion, and is the key observable capturing how consensus is reached. We show that if initially the two opinions are drawn independently from a Bernoulli distribution with parameter $u \in (0, 1)$, then on time scale 1 the fraction of discordant edges decreases and stabilises to a value that depends on d and u, and is related to the meeting time of two random walks on an infinite tree of degree d starting from two neighbouring vertices. Moreover, we show that on time scale n the fraction of discordant edges moves away from the constant plateau and converges to zero in an exponential fashion. Our proofs exploit the classical dual system of coalescing random walks and use ideas from Cooper et al. (2010) built on the so-called First Visit Time Lemma. We further introduce a novel technique to derive concentration properties from weak-dependence of coalescing random walks on moderate time scales., Comment: Manuscript matching published version
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- 2022
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8. Law of large numbers for ballistic random walks in dynamic random environments under lateral decoupling
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Arcanjo, Weberson S., Baldasso, Rangel, Hilário, Marcelo R., and Santos, Renato S. dos
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Mathematics - Probability ,60K35, 82B43 - Abstract
We establish a strong law of large numbers for one-dimensional continuous-time random walks in dynamic random environments under two main assumptions: the environment is required to satisfy a decoupling inequality that can be interpreted as a bound on the speed of dependence propagation, while the random walk is assumed to move ballistically with a speed larger than this bound. Applications include environments with strong space-time correlations such as the zero-range process and the asymmetric exclusion process., Comment: 33 pages. Accepted for publication in Annales de l'Institut Henri Poincar\'e, Probabilit\'es et Statistiques
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- 2022
9. Large deviations for marked sparse random graphs with applications to interacting diffusions
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Baldasso, Rangel, Oliveira, Roberto I, Pereira, Alan, and Reis, Guilherme
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Mathematics - Probability ,60F10, 05C80 - Abstract
We consider the empirical neighborhood distribution of marked sparse Erd\"os-R\'enyi random graphs, obtained by decorating edges and vertices of a sparse Erd\"os-R\'enyi random graph with i.i.d.\ random elements taking values on Polish spaces. We prove that the empirical neighborhood distribution of this model satisfies a large deviation principle in the framework of local weak convergence. We rely on the concept of BC-entropy introduced by Delgosha and Anantharam~(2019) which is inspired on the previous work by Bordenave and Caputo~(2015). Our main technical contribution is an approximation result that allows one to pass from graph with marks in discrete spaces to marks in general Polish spaces. As an application of the results developed here, we prove a large deviation principle for interacting diffusions driven by gradient evolution and defined on top of sparse Erd\"os-R\'enyi random graphs. In particular, our results apply for the stochastic Kuramoto model. We obtain analogous results for the sparse uniform random graph with given number of edges., Comment: 54 pages
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- 2022
10. Diving into the proteomic atlas of SARS-CoV-2 infected cells
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Victor C. Carregari, Guilherme Reis-de-Oliveira, Fernanda Crunfli, Bradley J. Smith, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Veronica M. Saia-Cereda, Pedro H. Vendramini, Paulo A. Baldasso, Lícia C. Silva-Costa, Giuliana S. Zuccoli, Caroline Brandão-Teles, André Antunes, Aline F. Valença, Gustavo G. Davanzo, João Victor Virgillio-da-Silva, Thiago dos Reis Araújo, Raphael Campos Guimarães, Felipe David Mendonça Chaim, Elinton Adami Chaim, Carolina Mie Kawagosi Onodera, Raissa Guimarães Ludwig, Tatiana Dandolini Saccon, André R. L. Damásio, Luiz Osório S. Leiria, Marco Aurélio R. Vinolo, Alessandro S. Farias, Pedro M. Moraes-Vieira, Marcelo A. Mori, José Luiz P. Módena, and Daniel Martins-de-Souza
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Medicine ,Science - Abstract
Abstract The COVID-19 pandemic was initiated by the rapid spread of a SARS-CoV-2 strain. Though mainly classified as a respiratory disease, SARS-CoV-2 infects multiple tissues throughout the human body, leading to a wide range of symptoms in patients. To better understand how SARS-CoV-2 affects the proteome from cells with different ontologies, this work generated an infectome atlas of 9 cell models, including cells from brain, blood, digestive system, and adipocyte tissue. Our data shows that SARS-CoV-2 infection mainly trigger dysregulations on proteins related to cellular structure and energy metabolism. Despite these pivotal processes, heterogeneity of infection was also observed, highlighting many proteins and pathways uniquely dysregulated in one cell type or ontological group. These data have been made searchable online via a tool that will permit future submissions of proteomic data ( https://reisdeoliveira.shinyapps.io/Infectome_App/ ) to enrich and expand this knowledgebase.
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- 2024
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11. Fire retainment on Cayley graphs
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Amir, Gideon, Baldasso, Rangel, Gerasimova, Maria, and Kozma, Gady
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Mathematics - Group Theory ,Mathematics - Combinatorics ,05C63, 05C57, 20F65, 05C10 - Abstract
We study the fire-retaining problem on groups, a quasi-isometry invariant introduced by Mart\'inez-Pedroza and Prytula [8], related to the firefighter problem. We prove that any Cayley graph with degree-$d$ polynomial growth does not satisfy $\{f(n)\}$-retainment, for any $f(n) = o(n^{d-2})$, matching the upper bound given for the firefighter problem for these graphs. In the exponential growth regime we prove general lower bounds for direct products and wreath products. These bounds are tight, and show that for exponential-growth groups a wide variety of behaviors is possible. In particular, we construct, for any $d\geq 1$, groups that satisfy $\{n^{d}\}$-retainment but not $o(n^d)$-retainment, as well as groups that do not satisfy sub-exponential retainment., Comment: 15 pages, 1 figure
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- 2021
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12. A proof of Sanov's Theorem via discretizations
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Baldasso, Rangel, Oliveira, Roberto I., Pereira, Alan, and Reis, Guilherme
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Mathematics - Probability ,60F10 - Abstract
We present an alternative proof of Sanov's theorem for Polish spaces in the weak topology that follows via discretization arguments. We combine the simpler version of Sanov's Theorem for discrete finite spaces and well chosen finite discretizations of the Polish space. The main tool in our proof is an explicit control on the rate of convergence for the approximated measures., Comment: Published version
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- 2021
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13. Dynamical noise sensitivity for the voter model
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Amir, Gideon, Angel, Omer, Baldasso, Rangel, and Peretz, Ron
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Mathematics - Probability ,82C22, 60J27, 60K35 - Abstract
We study noise sensitivity of the consensus opinion of the voter model on finite graphs, with respect to noise affecting the initial opinions and noise affecting the dynamics. We prove that the final opinion is stable with respect to small perturbations of the initial configuration, and is sensitive to perturbations of the dynamics governing the evolution of the process. Our proofs rely on the duality relationship between the voter model and coalescing random walks, and on a precise description of this evolution when we have coupled dynamics., Comment: 8 pages. Manuscript matching plublished version
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- 2021
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14. Habitat modification driven by land use as an environmental filter on the morphological traits of neotropical stream fish fauna
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Mara Cristina Baldasso, Anielly Galego de Oliveira, Bruna Caroline Kotz Kliemann, and Rosilene Luciana Delariva
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Ecomorphology ,Forest cover ,Freshwater fish ,Habitat loss ,Human pressure ,Zoology ,QL1-991 - Abstract
Abstract The ecomorphological attributes of fish are influenced by various factors inherent to their environment, enabling them to serve as indicators of environmental conditions resulting from habitat loss. We evaluated the variation in the ecomorphological characteristics of fish fauna considering the forest cover percentage in streams of the Iguaçu River basin, an ecoregion characterized by high endemism. Environmental variables were measured alongside fish collection by electrofishing with four samples per site. We evaluated 12 ecomorphological indices for 26 species. The combination of environmental variables resulting from forest cover loss and silting led to habitat homogenization, a significant factor in morphological structuring. Streams with lower forest cover showed a prevalence of morphological traits associated with enhanced performance in silted margins, such as caudal fin aspect ratio, dorsal and anal fin relative area, caudal peduncle relative width, pelvic fin aspect ratio. In contrast, the pectoral fin aspect ratio and ventral mouth orientation were traits positively related to the rocky substrate and forest streams. Thus, habitat loss and alteration have imposed selection pressures on species with more specialized traits and habitat use. These findings underscore the critical role of preserving forest cover in maintaining fish diversity.
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- 2024
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15. Local and global survival for infections with recovery
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Baldasso, Rangel and Stauffer, Alexandre
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Mathematics - Probability ,60K37, 60K35, 82C22 - Abstract
We establish two open problems from Kesten and Sidoravicius [8]. Particles are initially placed on $\Z^{d}$ with a given density and evolve as independent continuous-time random walks. Particles initially placed at the origin are declared as infected. Infection transmits instantaneously to healthy particles on the same site and infected particles become healthy with a positive rate. We prove that, for small enough recovery rates, the infection process survives and visits the origin infinitely many times on the event of survival. Second, we establish the existence of density parameters for which the infection survives for all choices of the recovery rate., Comment: 13 pages, manuscript matching published version
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- 2021
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16. Percolation phase transition on planar spin systems
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Alves, Caio, Amir, Gideon, Baldasso, Rangel, and Teixeira, Augusto
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Mathematics - Probability ,60K35, 82C22, 82C27 - Abstract
In this article we study the sharpness of the phase transition for percolation models defined on top of planar spin systems. The two examples that we treat in detail concern the Glauber dynamics for the Ising model and a Dynamic Bootstrap process. For both of these models we prove that their phase transition is continuous and sharp, providing also quantitative estimates on the two point connectivity. The techniques that we develop in this work can be applied to a variety of different dependent percolation models and we discuss some of the problems that can be tackled in a similar fashion. In the last section of the paper we present a long list of open problems that would require new ideas to be attacked., Comment: 40 pages, 4 figures
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- 2021
17. FINNger -- Applying artificial intelligence to ease math learning for children
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Audibert, Rafael Baldasso and Maschio, Vinicius Marinho
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Kids have an amazing capacity to use modern electronic devices such as tablets, smartphones, etc. This has been incredibly boosted by the ease of access of these devices given the expansion of such devices through the world, reaching even third world countries. Also, it is well known that children tend to have difficulty learning some subjects at pre-school. We as a society focus extensively on alphabetization, but in the end, children end up having differences in another essential area: Mathematics. With this work, we create the basis for an intuitive application that could join the fact that children have a lot of ease when using such technological applications, trying to shrink the gap between a fun and enjoyable activity with something that will improve the children knowledge and ability to understand concepts when in a low age, by using a novel convolutional neural network to achieve so, named FINNger.
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- 2021
18. Endoscopic Release of the Ulnar Nerve at the Elbow: Technique Description and Case Series
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Ricardo Kaempf de Oliveira, João Pedro Farina Brunelli, Matheus Baldasso Araújo, Márcio Aita, Vicente Carratalá, and Pedro J. Delgado
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ulnar nerve ,cubital tunnel syndrome ,nerve compression syndromes ,elbow ,paresthesia ,minimally invasive surgical procedures ,Medicine ,Orthopedic surgery ,RD701-811 - Abstract
Abstract Objective The endoscopic release of the ulnar nerve reproduces a simple (in situ) procedure with smaller incisions, less soft tissue damage, and higher preservation of nerve vascularization. Endoscopy allows the clear visualization of the entire path of the nerve and surrounding noble structures. Moreover, it reveals any signs of compression and allows a safe release of 10cm distally or proximally to the medial epicondyle. Methods A retrospective survey revealed that 15 subjects (1 with a bilateral injury) underwent an ulnar nerve compression release at the elbow using the endoscopic technique with Agee (Micro-Aire Sugical Instruments, Charlottesville, VA, EUA) equipment from January 2016 to January 2020. Results Symptoms of ulnar nerve compression improved in all patients; on average, they resumed their work activities in 26.5 days. There was no recurrence or need for another procedure. In addition, there were no severe procedure-related complications, such as infection and nerve or vascular injury. One patient had transient paresthesia of the sensory branches to the forearm, with complete functional recovery in 8 weeks. Conclusion Our study shows that the endoscopic release of the ulnar nerve at the elbow with the Agee equipment is a safe, reliable technique with good outcomes.
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- 2023
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19. El cuidado de sí: palabra y cuerpo en la formación de profesora/es de Educación Física
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Santiago Pich, Cristiano Mezzaroba, Fabiana Cristina Turelli, Alceu Junior Maciel, Letícia Baldasso Moraes, and Paulo César de Carvalho Jacó
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Cuerpo ,Palabra ,Formación de profesores ,Ética ,Política ,Education (General) ,L7-991 - Abstract
El ensayo problematiza la idea moderna de formación de profesores de educación física referenciada en la noción de cuidado de sí a partir de la elaboración de Michel Foucault. Ese movimiento nos lleva a pensar la relación entre cuerpo y verdad que es constitutiva del modo hegemónico de formación de profesores construida con base en el par pedagogía-profesor(a) y a cuestionar la imposibilidad de la formación del sujeto ético en ese registro en el contexto de una política democrática. Por otro lado, con base en el concepto de cuidado de sí y en el par psicagogía-parresiasta elaboramos algunos principios que nos permiten construir otro modo de formación docente en el campo de la educación física, que tienen como clivaje la constitución del sujeto ético para la vida en común.
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- 2024
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20. Disrupted hemodynamic response within dorsolateral prefrontal cortex during cognitive tasks among people with multiple sclerosis-related fatigue
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Bruna D. Baldasso, Syed Z. Raza, Sadman S. Islam, Isabella B. Burry, Caitlin J. Newell, Sydney R. Hillier, and Michelle Ploughman
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Medicine ,Science - Published
- 2024
21. Valorization of Wastes Generated in Organic Grape Processing
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Márcia Zanini, Wendel Paulo Silvestre, Camila Baldasso, and Isabel Cristina Tessaro
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Agricultural waste ,antioxidant capacity ,chemical composition ,‘Ives noir’ grape ,phenolic compounds ,Biotechnology ,TP248.13-248.65 - Abstract
Abstract The development potential of byproducts from wastes of grape processing can be a promising alternative due to environmental questions. Moreover, there is the possibility of using this material in the development of products with added value. In this study, the wastes of grape skin (GSk), grape seed (GSe), and defatted grape seed with skin fragments (DGS) from ‘Ives noir’ grape (Vitis labrusca L.), grown under organic farming conditions, had their chemical composition and physical-chemical properties evaluated. Parameters of chemical composition, contents of phenolic compounds, total anthocyanins, flavonoids, and minerals, the antioxidant capacity, and water sorption capacity were evaluated. The wastes of grape were also analyzed by FTIR and TG/DTG. All residues had a high fiber content (54.1 - 74.3 wt.%), the DGS waste had the highest contents of phenolic compounds as flavonoids, and the GSk waste had the highest content of total anthocyanins. Antioxidant capacity values were higher in the ABTS+ method, with no statistical difference. On the other hand, in the DPPH antioxidant assay, the DGS and GSe wastes had higher antioxidant activity; these wastes also had greater thermal stability. The GSk waste had the highest water sorption capacity. The results show that the wastes from grape processing have the potential to be reused in applications with more value added.
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- 2024
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22. Local survival of spread of infection among biased random walks
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Baldasso, Rangel and Stauffer, Alexandre
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Mathematics - Probability ,60K37, 60K35, 82C22 - Abstract
We study infection spread among biased random walks on $\mathbb{Z}^{d}$. The random walks move independently and an infected particle is placed at the origin at time zero. Infection spreads instantaneously when particles share the same site and there is no recovery. If the initial density of particles is small enough, the infected cloud travels in the direction of the bias of the random walks, implying that the infection does not survive locally. When the density is large, the infection spreads to the whole $\mathbb{Z}^{d}$. The proofs rely on two different techniques. For the small density case, we use a description of the infected cloud through genealogical paths, while the large density case relies on a renormalization scheme., Comment: 31 pages, 4 figures. Manuscript matching published version
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- 2020
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23. The firefighter problem on polynomial and intermediate growth groups
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Amir, Gideon, Baldasso, Rangel, and Kozma, Gady
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Mathematics - Group Theory ,Computer Science - Discrete Mathematics ,Mathematics - Combinatorics ,05C63, 05C57 05C63, 05C57 20F65, 05c63, 05c57, 05C10 - Abstract
We prove that any Cayley graph $G$ with degree $d$ polynomial growth does not satisfy $\{f(n)\}$-containment for any $f=o(n^{d-2})$. This settles the asymptotic behaviour of the firefighter problem on such graphs as it was known that $Cn^{d-2}$ firefighters are enough, answering and strengthening a conjecture of Develin and Hartke. We also prove that intermediate growth Cayley graphs do not satisfy polynomial containment, and give explicit lower bounds depending on the growth rate of the group. These bounds can be further improved when more geometric information is available, such as for Grigorchuk's group., Comment: 5 pages
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- 2020
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24. Correction to: Cutaneous protothecosis in a dog successfully treated with oral itraconazole in pulse dosing
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Gmyterco, Vanessa Cunningham, Jagielski, Tomasz, Baldasso, Gustavo, Bacher, Louise Helene, Ribeiro, Marcio Garcia, and de Farias, Marconi Rodrigues
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- 2023
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25. Comprehensive bronchoalveolar lavage characterization in COVID-19 associated acute respiratory distress syndrome patients: a prospective cohort study
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Calabrese, Fiorella, Lunardi, Francesca, Baldasso, Elisa, Pezzuto, Federica, Kilitci, Asuman, Olteanu, Gheorghe-Emilian, Del Vecchio, Claudia, Fortarezza, Francesco, Boscolo, Annalisa, Schiavon, Marco, Vedovelli, Luca, Cattelan, Annamaria, Gregori, Dario, Rea, Federico, and Navalesi, Paolo
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- 2023
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26. Cutaneous protothecosis in a dog successfully treated with oral itraconazole in pulse dosing
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Gmyterco, Vanessa Cunningham, Jagielski, Tomasz, Baldasso, Gustavo, Bacher, Louise Helene, Ribeiro, Márcio Garcia, and de Farias, Marconi Rodrigues
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- 2023
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27. Comprehensive bronchoalveolar lavage characterization in COVID-19 associated acute respiratory distress syndrome patients: a prospective cohort study
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Fiorella Calabrese, Francesca Lunardi, Elisa Baldasso, Federica Pezzuto, Asuman Kilitci, Gheorghe-Emilian Olteanu, Claudia Del Vecchio, Francesco Fortarezza, Annalisa Boscolo, Marco Schiavon, Luca Vedovelli, Annamaria Cattelan, Dario Gregori, Federico Rea, and Paolo Navalesi
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ARDS ,Bronchoalveolar lavage ,COVID-19 ,Cytokine profile ,Microbiology ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract COVID-19-related acute respiratory distress syndrome (CARDS) is associated with high mortality rates. We still have limited knowledge of the complex alterations developing in the lung microenvironment. The goal of the present study was to comprehensively analyze the cellular components, inflammatory signature, and respiratory pathogens in bronchoalveolar lavage (BAL) of CARDS patients (16) in comparison to those of other invasively mechanically ventilated patients (24). In CARDS patients, BAL analysis revealed: SARS-CoV-2 infection frequently associated with other respiratory pathogens, significantly higher neutrophil granulocyte percentage, remarkably low interferon-gamma expression, and high levels of interleukins (IL)-1β and IL-9. The most important predictive variables for worse outcomes were age, IL-18 expression, and BAL neutrophilia. To the best of our knowledge, this is the first study that was able to identify, through a comprehensive analysis of BAL, several aspects relevant to the complex pathophysiology of CARDS.
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- 2023
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28. A Proof of Sanov’s Theorem via Discretizations
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Baldasso, Rangel, Oliveira, Roberto I., Pereira, Alan, and Reis, Guilherme
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- 2023
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29. Membrane separation process of microfiltration applied to the filtration of kombuchas
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Júlia Daneluz, Guilherme Ferreira da Silva, Jocelei Duarte, Tayse Circe Turossi, Venina dos Santos, Camila Baldasso, and Ana Carolina Daneluz
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Functional beverages ,Fermentation ,Microfitlration ,Kombucha ,Membranes ,Filtration ,Food processing and manufacture ,TP368-456 - Abstract
Kombucha is a drink prepared from the fermentation of add sugars in teas infusions. Residues from the fermentation may not be visually pleasing to some consumers. Residual microorganisms from fermentation continue to be in constant activity and result in microbiological instability. Most commercialized kombuchas do not use techniques to improve these properties. A new alternative to minimize these characteristics is the use of membrane separation process. This process has not yet been used to improve kombuchas. This study aimed to evaluate microfiltration in kombuchas, in order to reduce turbidity, suspended solids concentration and the amount of residual microorganisms from fermentation. The samples were submitted to analysis of the parameters of turbidity, suspended and dissolved solids, microbial count, pH, volatile acidity, alcohol content and organoleptic evaluation. Microfiltration reduced turbidity (80,18–83,30 %), suspended solids (66.40–79,33 %) and microorganisms (53,93 %), due to these components are larger than the membrane pores and have been retained in the processes. The microfiltration did not affect the other evaluated parameters, because the components responsible for these properties are smaller than the pores of the membrane and permeate with the sample. The microfiltered kombuchas were visually clearer. That proved that the technique was efficient for the proposed purpose.
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- 2023
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30. Pectin-based films with thyme essential oil: production, characterization, antimicrobial activity, and biodegradability
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Greice Ribeiro Furlan, Wendel Paulo Silvestre, and Camila Baldasso
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active packaging ,biological activity ,biopolymer ,terpenes ,Chemical technology ,TP1-1185 - Abstract
Abstract This work aimed to incorporate thyme essential oil into films composed of pectin to provide antimicrobial action to them. The effect of adding essential oil on the films' mechanical, physical-chemical, and barrier properties and their degradability was evaluated. Essential oil addition was possible by using Tween® 20 as an emulsifier, and it was possible to observe antimicrobial activity in the films containing 1.0 wt.% and 2.0 wt.% essential oil. The films containing thyme essential oil were more elastic and thicker but less resistant, with high permeability to water vapor and more hydrophilic relative to other formulations. Scanning electron microscopy analysis showed the presence of heterogeneities in the formulations with essential oil. The films produced using the optimized formulation (30 wt.% glycerol, 1.0 wt.% thyme essential oil, and 0.5 wt.% Tween® 20 relative to pectin mass) degraded entirely after 24 days of exposure to standard soil.
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- 2023
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31. Metal mobility in an anaerobic-digestate-amended soil: the role of two bioenergy crop plants and their metal phytoremediation potential
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Neus Bonet-Garcia, Veronica Baldasso, Valentin Robin, Carlos R. Gomes, Gilles Guibaud, Maria João Alves, Ricardo Castro, Ana Paula Mucha, and C. Marisa R. Almeida
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anaerobic digestate ,trace metals ,phytoremediation ,bioenergy crop plants ,soil reclamation ,Environmental sciences ,GE1-350 - Abstract
Panicum virgatum and Pennisetum alopecuroides, two non-food bioenergy crops, were evaluated for their capacity to phyto-manage trace metals (Pb, Zn, Ni, Fe, Mn, Co, Cr, and Cu) from municipal solid waste digestate after its application to a marginal soil. For that, 90-day vertical soil column mesocosm (columns with 0.6 × 0.2 m) experiments were carried out to assess 1) the impact of digestate application on the health of marginal soil, 2) plant effect on digestate-borne trace metals’ mobility along the soil profile (measuring total metal levels and fractionation in different soil layers by atomic absorption spectroscopy, and 3) plant growth performance and trace metal (Pb, Zn, and Cu) uptake capacity. The results showed that trace metals were mostly confined in the 0–0.2 m soil horizon over the course of the experimental period, migrating from the digestate-amended soil layer (0–0.1 m) to the layer underneath (0.1–0.2 m) within the first 21 days and remaining stable afterward. No evidence of the trace metals’ mobility to deeper soil layers was detected. Migration of trace metals was reduced in the presence of P. virgatum and P. alopecuroides, suggesting a phytoremediation (phytostabilization) effect. For both plant species, no trace metal accumulation in the roots was observed (bioconcentration factor 1). The growth of both plants was positively affected by municipal solid waste digestate application, which also improved soil quality (increased concentration of total organic carbon and available phosphorus, as well as cation exchange capacity and water holding capacity).
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- 2023
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32. Sharp threshold for two-dimensional majority dynamics percolation
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Alves, Caio and Baldasso, Rangel
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Mathematics - Probability - Abstract
In this work we consider the two-dimensional percolation model arising from the majority dynamics process at a given time $t\in\mathbb{R}_+$. We show the emergence of a sharp threshold phenomenon for the box crossing event at the critical probability parameter $p_c(t)$ with polynomial size window. We then use this result in order to obtain stretched-exponential bounds on the one-arm event probability in the subcritical phase. Our results are based on differential inequalities derived from the OSSS inequality, inspired by the recent developments by Ahlberg, Broman, Griffiths, and Morris and by Duminil-Copin, Raoufi, and Tassion. We also provide analogous results for percolation in the voter model., Comment: 24 pages, 1 figure. Version accepted for publication
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- 2019
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33. Large deviations for interacting diffusions with path-dependent McKean-Vlasov limit
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Baldasso, Rangel, Pereira, Alan, and Reis, Guilherme
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Mathematics - Probability ,60F10, 35R60 - Abstract
We consider a mean-field system of path-dependent stochastic interacting diffusions in random media over a finite time window. The interaction term is given as a function of the empirical measure and is allowed to be non-linear and path dependent. We prove that the sequence of empirical measures of the full trajectories satisfies a large deviation principle with explicit rate function. The minimizer of the rate function is characterized as the path-dependent McKean-Vlasov diffusion associated to the system. As corollary, we obtain a strong law of large numbers for the sequence of empirical measures. The proof is based on a decoupling technique by associating to the system a convenient family of product measures. To illustrate, we apply our results for the delayed stochastic Kuramoto model and for a SDE version of Galves-L\"ocherbach model., Comment: This version coincides with the published one
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- 2019
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34. Majority dynamics and the median process: connections, convergence and some new conjectures
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Amir, Gideon, Baldasso, Rangel, and Beilin, Nissan
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Mathematics - Probability ,Computer Science - Discrete Mathematics - Abstract
We consider the median dynamics process in general graphs. In this model, each vertex has an independent initial opinion uniformly distributed in the interval [0,1] and, with rate one, updates its opinion to coincide with the median of its neighbors. This process provides a continuous analog of binary majority dynamics. We deduce properties of median dynamics through this connection and raise new conjectures regarding the behavior of majority dynamics on general graphs. We also prove these conjectures on some graphs where majority dynamics has a simple description., Comment: 30 pages, 3 figures. Manuscript matching plublished version
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- 2019
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35. Percolation in majority dynamics
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Amir, Gideon and Baldasso, Rangel
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Mathematics - Probability ,82C43, 82B43, 82C22 - Abstract
We consider two-dimensional dependent dynamical site percolation where sites perform majority dynamics. We introduce the critical percolation function at time t as the infimum density with which one needs to begin in order to obtain an infinite open component at time t. We prove that, for any fixed time t, there is no percolation at criticality and that the critical percolation function is continuous. We also prove that, for any positive time, the percolation threshold is strictly smaller than the critical probability for independent site percolation., Comment: 25 pages, 3 figures
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- 2019
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36. Cutaneous protothecosis in a dog successfully treated with oral itraconazole in pulse dosing
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Vanessa Cunningham Gmyterco, Tomasz Jagielski, Gustavo Baldasso, Louise Helene Bacher, Márcio Garcia Ribeiro, and Marconi Rodrigues de Farias
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CYTB gene ,Genetic identification ,MALDI-TOF MS ,Prototheca sp. ,Prototheca wickerhamii ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Protothecosis is a rare infectious disease caused by unicellular, achlorophyllous, microalgae of the genus Prototheca, ubiquitously distributed in nature. The algae are emerging pathogens, whose incidence is increasing in both human and animal populations and serious systemic infections related to this pathogen have been increasingly described in humans in recent years. After mastitis in dairy cows, canine protothecosis is the second most prevalent form of the protothecal disease in animals. Here, we report the first case of chronic cutaneous protothecosis due to P. wickerhamii in a dog in Brazil, successfully treated with a long-term therapy with itraconazole in pulse. Case presentation Upon clinical examination, exudative nasolabial plaque, ulcered, and painful lesions in central and digital pads and lymphadenitis were observed in a 2-year-old mixed-breed dog, with a 4-month history of cutaneous lesions and contact with sewage water. Histopathological examination revealed intense inflammatory reaction, with numerous spherical to oval, encapsulated structures stained with Periodic Acid Schiff, compatible with Prototheca morphology. Tissue culture on Sabouraud agar revealed yeast-like, greyish-white colonies after 48 h of incubation. The isolate was subjected to mass spectrometry profiling and PCR-sequencing of the mitochondrial cytochrome b (CYTB) gene marker, leading to identification of the pathogen as P. wickerhamii. The dog was initially treated with oral itraconazole at a dosage of 10 mg/kg once daily. After six months, the lesions resolved completely, yet recurred shortly after cessation of therapy. The dog was then treated with terbinafine at a dose of 30 mg/kg, once daily for 3 months, with no success. The resolution of clinical signs, with no recurrence over a 36-months follow-up period, was achieved after 3 months of treatment with itraconazole (20 mg/kg) in pulse intermittently on two consecutive days a week. Conclusions This report highlights the refractoriness of skin infections by Prototheca wickerhamii with therapies proposed in the literature and suggests a new treatment option with oral itraconazole in pulse dosing for long-term disease control successfully performed in a dog with skin lesions.
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- 2023
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37. Evaluation of tumor load in sentinel lymph node in patients with cutaneous melanoma
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PEDRO DEAK DE ALMEIDA, LUCCAS LAVAREZE, CAROLINA EMERICK DA SILVA RANGEL, FERNANDA VIVIANE MARIANO, DIEGO VICTOR NUNES RODRIGUES, TIAGO ANTONIO BALDASSO, RENATO VENTURA FANNI, ANDRE LUIS MAION CASARIM, ANDRÉ DEL NEGRO, and ALFIO JOSÉ TINCANI
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Melanoma ,Sentinel Lymph Node ,Diagnosis ,Surgery ,RD1-811 - Abstract
ABSTRACT Introduction: cutaneous melanoma (MC) is a malignant neoplasm derived from melanocytic cells with an aggressive behavior. It is usually associated with the multifactorial interaction of genetic susceptibility and environmental exposure, usually ultraviolet radiation. Despite advances in treatment, the disease remains relentless with poor prognosis. Sentinel lymph node (SLN) biopsy is a technique used to screen patients in need of lymph node dissection. Objectives: to correlate the tumor burden in the SLN with the mortality of patients undergoing SLN biopsy. Methodology: the medical records and histological slides of patients with MC who underwent SLN biopsy treated at HC-Unicamp from 2001 to 2021 were retrospectively analyzed. The positive SLN were measured according to the size of the tumor infiltration area, for analysis of the depth of invasion (DI), closest proximity to the capsule (CPC) and tumor burden (TB). For statistical analysis, associations between variables were analyzed using Fishers exact test, with post Bonferroni test and Wilcoxon test. Results: 105 records of patients who underwent SLN biopsy of MC were identified. Of these, nine (8.6%) had positive SLN and 81 (77.1%) had negative SLN. The performed lymphadenectomies resulted in 55.6% (n=5) affected, 22.2% (n=2) without disease and 22.2% (n=2) were not performed. Mean CPC, TB, and DI were 0.14mm, 32.10mm and 2.33mm, respectively. Patients with T2 and T3 tumors were more likely to show the SLN affected (p=0.022). No patient with positive SLN died during follow-up. Conclusion: patients who presented T3 staging are the ones who most presented positive SLN.
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- 2023
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38. Antibiotic Resistance to Molecules Commonly Prescribed for the Treatment of Antibiotic-Resistant Gram-Positive Pathogens: What Is Relevant for the Clinician?
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Gianpiero Tebano, Irene Zaghi, Francesco Baldasso, Chiara Calgarini, Roberta Capozzi, Caterina Salvadori, Monica Cricca, and Francesco Cristini
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Gram-positive bacterial infections ,antibiotic resistance ,daptomycin ,dalbavancin ,linezolid ,tedizolid ,Medicine - Abstract
Antibiotic resistance in Gram-positive pathogens is a relevant concern, particularly in the hospital setting. Several antibiotics are now available to treat these drug-resistant pathogens, such as daptomycin, dalbavancin, linezolid, tedizolid, ceftaroline, ceftobiprole, and fosfomycin. However, antibiotic resistance can also affect these newer molecules. Overall, this is not a frequent phenomenon, but it is a growing concern in some settings and can compromise the effectiveness of these molecules, leaving few therapeutic options. We reviewed the available evidence about the epidemiology of antibiotic resistance to these antibiotics and the main molecular mechanisms of resistance, particularly methicillin-resistant Sthaphylococcus aureus, methicillin-resistant coagulase-negative staphylococci, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. We discussed the interpretation of susceptibility tests when minimum inhibitory concentrations are not available. We focused on the risk of the emergence of resistance during treatment, particularly for daptomycin and fosfomycin, and we discussed the strategies that can be implemented to reduce this phenomenon, which can lead to clinical failure despite appropriate antibiotic treatment. The judicious use of antibiotics, epidemiological surveillance, and infection control measures is essential to preserving the efficacy of these drugs.
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- 2024
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39. Transglutaminase effect on the gelatin-films properties
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Baggio, Elizete, Scopel, Bianca Santinon, Rosseto, Marieli, Rigueto, Cesar Vinicius Toniciolli, Dettmer, Aline, and Baldasso, Camila
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- 2022
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40. Spread of an infection on the zero range process
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Baldasso, Rangel and Teixeira, Augusto
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Mathematics - Probability ,60K37, 60K35, 82C22 - Abstract
We study the spread of an infection on top of a moving population. The environment evolves as a zero range process on the integer lattice starting in equilibrium. At time zero, the set of infected particles is composed by those which are on the negative axis, while particles at the right of the origin are considered healthy. A healthy particle immediately becomes infected if it shares a site with an infected particle. We prove that the front of the infection wave travels to the right with positive and finite velocity. As a central step in the proof of these results, we prove a space-time decoupling for the zero range process which is interesting on its own. Using a sprinkling technique, we derive an estimate on the correlation of functions of the space of trajectories whose supports are sufficiently far away., Comment: 38 pages, 8 figures. Version accepted for publication
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- 2018
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41. Desempenho e qualidade da carne de novilhas Nelore e F1 Nelore x Rubia Gallega suplementadas com cromo picolinato
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Natália Baldasso Romero, Bruno Gomes de Castro, Rodolfo Cassimiro de Araujo Berber, and Paulo Sérgio Andrade Moreira
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análise físico-química, carcaça, crescimento, cruzamento, minerais ,General Works - Abstract
Objetivou-se avaliar o desempenho, as características de carcaça e da carne de novilhas Nelore (NEL) e F1 Nelore x Rubia Gallega (NRG), suplementadas com adição de Cromo Picolinato (CrP). Foram avaliados 28 animais, que foram mantidos em dois piquetes contendo Brachiaria brizantha cv. Marandu, separados conforme a suplementação (com e sem CrP). Para as análises físico-químicas foram coletadas amostras do músculo Longissimus thoracis, entre a 12° e 13° costelas, em que foram avaliadas as perdas por exsudação, pH, espessura de gordura, coloração, perdas por cocção, maciez e composição química. O delineamento adotado foi inteiramente casualizado, em arranjo fatorial 2x2 (dois grupos genéticos x dois tipos de suplementação). O grupo genético, apresentou diferenças para as variáveis peso corporal final, peso de carcaça quente e rendimento de carcaça quente, com superioridade para os animais NRG (386,48 kg; 209,33 kg; 54,09 %) contra os animais NEL (378,59 kg; 203,93 kg; 53,85%). A nota para o acabamento de carcaça nos animais NRG foi menor que nos animais NEL (2,71 x 3,35). Para as características da carne houve menor espessura de gordura nos animais NRG (3,25 mm), do que nos animais NEL (7,84 mm) e as perdas por exsudação, foram maiores nos animais NRG quando comparadas aos animais NEL (9,45% x 5,68%). Novilhas NRG apresentam melhor desempenho e menor deposição de gordura quando comparadas aos animais NEL. A suplementação com CrP em nada influencia no desempenho de novilhas na fase de terminação e nas características de carcaça e de carne dos animais.
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- 2023
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42. IDAA1C como fator preditor para nefropatia diabética em pacientes com diabetes mellitus tipo 1
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Alessandra Lima Veras de Menezes Cavalcante Girão, Marina Baldasso, Luciana Felipe Férrer Aragão, Annelise Barreto de Carvalho, Jaquellyne Gurgel Penaforte Saboia, Mayara Teixeira Alexandrino Sales, and Milena Silva Sousa
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diabetes mellitus tipo 1 ,complicações do diabetes ,nefropatias ,Medicine ,Medicine (General) ,R5-920 - Abstract
Objetivos: Comparar função residual de célula beta pancreática através do cálculo do IDAA1C (dose de insulina ajustada para HbA1C) entre pacientes pediátricos com diabetes mellitus tipo 1 (DM1) que desenvolveram nefropatia diabética e aqueles sem complicações microvasculares. Metodologia: Estudo retrospectivo descritivo realizado através da análise de prontuários de pacientes DM1 acompanhados no ambulatório de Endocrinologia Pediátrica do Hospital Universitário Walter Cantídio (HUWC). Os dados coletados foram: sexo, idade, dados antropométricos, estágio puberal, tempo de doença, tipo de insulina, dose diária de insulina, dosagem de microalbuminúria e níveis de HbA1C. Resultados: A mediana de duração do diabetes em anos até o diagnóstico de nefropatia foi 3.2 anos. No ano anterior ao diagnóstico de nefropatia, 15,4% dos pacientes nefropatas ainda possuíam reserva pancreática (IDAA1C
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- 2022
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43. Broad-Spectrum Cannabis Oil Alleviates Behavioral Symptoms Associated with Stress-Related Anxiety and Depression in Mice
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Pollyana Mendonça de Assis, Eduarda Gomes Ferrarini, Gabriela Mantovani Baldasso, Rodrigo Sebben Paes, Murilo Chaves Gouvêa, Carlos Espínola Neto Segundo, Francesca Borrelli, Marcos Antônio Fernandes Brandão, Raffaelle Capasso, Rafael Cypriano Dutra, and Nádia Rezende Barbosa Raposo
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anxiety ,broad-spectrum cannabis oil ,cannabis sp ,depression ,posttraumatic stress disorder ,Pharmacy and materia medica ,RS1-441 - Abstract
Background: Posttraumatic stress disorder (PTSD) is a psychiatric condition that manifests through a broad range of symptoms and shares several phenotypes with anxiety and depression. Refractory PTSD affects 10–30% of the patients and highlights the need for alternative pharmacotherapy. The suggested involvement of the endocannabinoid system (ECS) with the emotional processes has enlightened the use of Cannabis sp. Then, this study aimed to evaluate the therapeutic effects of a broad-spectrum Cannabis oil on anxiety- and depressive-like behaviors triggered by stressors from combined nature. In addition, this study investigated the effect of the oil on central cannabinoid receptor 1 and serum levels of cytokines, chemokines, and growth factors. Methods: Mice were randomized into five groups (vehicle; Cannabis oil; fluoxetine; single oral dose) and submitted to acute restraint and chronic unpredictable stress. Then, they were behaviorally assessed in the elevated plus-maze test (EPMT), forced swimming test (FST), splash test (ST), and open field test (OFT). The tetrad cannabinoid assay evaluated the central effect of the oil. Serum biomarkers levels were measured by a multiplex bead-based assay. Results: Cannabis oil (0.1 mg/kg, p.o.) significantly reduced the anxiety-like behavior in EPMT in the acute restraint stress model (p < 0.05) as compared to vehicle. Moreover, compared to the vehicle, Cannabis oil significantly reverted the despair and anhedonic-like behaviors in FST (p < 0.05) and ST (p < 0.05), respectively, in chronically stressed mice. Yet, compared to vehicle, therapy with Cannabis oil did not induce cannabinoid-tetrad (p < 0.0001); downregulated granulocyte-macrophage colony-stimulating factor (GM-CSF; p < 0.01) and advanced glycation end-products (RAGE; p < 0.0001); and upregulated vascular endothelial growth factor (VEGF; p < 0.01) serum levels. Conclusion: Altogether, our data suggest the potential of the broad-spectrum Cannabis oil to improve symptoms related to anxiety and depression caused by traumatic events.
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- 2022
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44. Noise sensitivity and Voronoi percolation
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Ahlberg, Daniel and Baldasso, Rangel
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Mathematics - Probability ,Mathematics - Combinatorics ,60K35, 82B43, 60G55 - Abstract
In this paper we study noise sensitivity and threshold phenomena for Poisson Voronoi percolation on $\mathbb{R}^2$. In the setting of Boolean functions, both threshold phenomena and noise sensitivity can be understood via the study of randomized algorithms. Together with a simple discretization argument, such techniques apply also to the continuum setting. Via the study of a suitable algorithm we show that box-crossing events in Voronoi percolation are noise sensitive and present a threshold phenomenon with polynomial window. We also study the effect of other kinds of perturbations, and emphasize the fact that the techniques we use apply for a broad range of models., Comment: 29 pages, 2 figures
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- 2017
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45. Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice
- Author
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Carlos Pereira Martins, Rodrigo Sebben Paes, Gabriela Mantovani Baldasso, Eduarda Gomes Ferrarini, Rahisa Scussel, Rubya Pereira Zaccaron, Ricardo Andrez Machado-de-Ávila, Paulo Cesar Lock Silveira, and Rafael Cypriano Dutra
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dopamine ,dopaminergic system ,fibromyalgia ,hyperalgesia ,pain ,pramipexole ,reserpine ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Fibromyalgia (FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole (PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plus-maze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH (2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage (carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina (UFSC) Ethics Committee (approval No. 2572210218) on May 10, 2018.
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- 2022
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46. Development and validation of a flow cytometry antibody test for Lawsonia intracellularis
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Débora Zini Baldasso, João Antônio Guizzo, Cláudia Cerutti Dazzi, Gabriela Carolina Paraboni Frandoloso, César Feronato, Stephan von Berg, Roberto Maurício Carvalho Guedes, Heather Lynne Wilson, Luiz Carlos Kreutz, and Rafael Frandoloso
- Subjects
Lawsonia intracellularis ,Ileitis ,pig ,diagnostic test ,flow cytometry assay ,serological antibody detection ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Lawsonia intracellularis is the etiologic agent of porcine proliferative enteropathy (PPE), an inflammatory bowel disease with a major economic impact on the pig industry. The serological diagnosis of PPE can be performed using Blocking or Indirect ELISA, Immunoperoxidase Monolayer Assay (IPMA) and Indirect Fluorescence Antibody Test (IFAT). Here, we designed a most sophisticated immunological method for the detection of porcine anti-L. intracellularis IgGs, named Flow Cytometry Antibody Test - FCAT. This assay uses whole, live-attenuated L. intracellularis bacteria derived from a commercial vaccine. For the assay, we set up the optimal antigen concentration (106 bacterium/assay), primary antibody dilution (1:100), time of incubation (20 min), antigen stability (15 days), precision (coefficient of variation - CV < 10%), reproducibility (CV ≤ 13%) and Receiver Operating Characteristic (ROC). When using a cut-off of >15.15% for FCAT, we determined that it showed a sensitivity of 98.8% and specificity of 100%. The rate of agreement with IPMA was 84.09% with a kappa index of 0.66. FCAT was used to screen 1,000 sera from non-vaccinated pigs housed in 22 different farms and we found that 730 pigs (73%) from 16 farms (72.7%) had L. intracellularis IgG. This high prevalence confirms that L. intracellularis is endemic on Brazilian pig farms. Finally, we determined that FCAT is an easy to perform diagnostic assay and we would highly recommend it for: i) seroepidemiological studies; ii) evaluation of infection dynamics; and iii) characterization of the humoral response profile induced by vaccines.
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- 2023
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47. Socialização acadêmica de estudantes em uma universidade pública de pesquisa: variações da experiência estudantil na relação com o capital cultural
- Author
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Célia Elizabete Caregnato, Bernardo Sfredo Miorando, and Julio Cesar Baldasso
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Socialização acadêmica ,Educação superior ,Estudantes ,Capital cultural ,Theory and practice of education ,LB5-3640 - Abstract
RESUMO Este artigo explora quais fatores contribuem para a socialização acadêmica entre um grupo de possíveis componentes desse processo. A questão se coloca no contexto de ampliação e diversificação do público estudantil nas universidades públicas brasileiras para além de grupos sociais detentores de elevado capital cultural. Para analisar a socialização acadêmica de estudantes universitários, elaborou-se uma escala abrangendo itens relativos a: atividades acadêmicas priorizadas na experiência estudantil; valoração de aprendizados; e dificuldades expressas pelos estudantes. Também foram analisadas variáveis de contexto. Trata-se de um estudo exploratório, de abordagem quantitativa com análises descritivas, examinando comparações de média e correlações. Os dados analisados foram obtidos de 1.185 respostas a um survey aplicado no ano de 2021 entre estudantes de graduação da Universidade Federal do Rio Grande do Sul. Os resultados indicam socialização acadêmica mais intensa entre estudantes que participaram de programas acadêmicos extracurriculares. Convergindo com a literatura sociológica recente, há casos de alta socialização acadêmica relacionados a indicadores tradicionais de composição do capital cultural. Porém, verificou-se que outras experiências formativas disponíveis a estudantes de origens sociais menos favorecidas também repercutem em maior intensidade na socialização acadêmica, como é o caso de programas extracurriculares de iniciação à pesquisa, à extensão e à docência. A interpretação dos dados sugere que o investimento institucional em tais programas e no diálogo com formas variadas de capital cultural desenvolvidas pelos estudantes pode produzir um maior aproveitamento da experiência universitária.
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- 2023
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48. Trace metal fate in soil after application of digestate originating from the anaerobic digestion of non-source-separated organic fraction of municipal solid waste
- Author
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Veronica Baldasso, Neus Bonet-Garcia, Stéphanie Sayen, Emmanuel Guillon, Luigi Frunzo, Carlos A. R. Gomes, Maria João Alves, Ricardo Castro, Ana Paula Mucha, and C. Marisa R. Almeida
- Subjects
trace metals ,municipal solid waste digestate ,metal bioavaibility ,soil-metal interaction ,metal dynamics ,Environmental sciences ,GE1-350 - Abstract
Introduction: Digestate originating from anaerobic digestion of non-source-separated organic fraction of municipal solid waste (OFMSW) is produced abundantly worldwide and generally discarded in landfills. However, it can be a valuable resource for many bioeconomy strategies as land restoration, only if a consolidated understanding of the contaminants’ presence and behaviour in digestate-amended soil is achieved. This study aimed to investigate the fate of trace metals, namely Zn, Cu, Pb, and Cr found in the digestate, along the soil profile after digestate application on soil, and the influence that other contaminants as pharmaceutical compounds can have on their behaviour in the soil system.Methods: For that, a 90-day soil column experiment was conducted using a fine loamy sand soil topped with a layer of digestate-amended soil. Digestate-amended soil had a soil to digestate proportion of 14 to 1 (dry weight). Two experimental conditions were tested: soil amended with digestate, and soil amended with digestate spiked with the antidiabetic drug metformin. Soil samples were taken at 4 depths on days 1, 7, 21, 35 and 90, and total trace metals concentrations and fractionation were determined via atomic absorption spectroscopy.Results: Results showed that Zn, Cu, Pb ad Cr initially present in the digestate were transferred from the digestate-amended soil layer to the underlying soil layer over time, although in low amounts. Nevertheless, no transfer was detected to the deeper soil layers. Trace metals in soil were predominantly in immobile and less bioavailable forms associated with clay and silicate mineral groups, whereas in the digestate-amended soil they were in more bioavailable forms, which could be related to metals’ migration in the soil layers below. Results also show that the presence of metformin had no influence on trace metal behaviour, giving insight also on possible interactions with other potentially present contaminants as microplastics.Conclusion: The current study showed that OFMSW digestate can be a promising organic nutrient-rich matrix for land restoration even if it may contain high metals’ concentrations because low metal mobility along the soil profile can be expected.
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- 2023
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49. How can a clairvoyant particle escape the exclusion process?
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Baldasso, Rangel and Teixeira, Augusto
- Subjects
Mathematics - Probability ,60K37, 60K35, 82B43, 82C22 - Abstract
We study a detection problem in the following setting: On the one-dimensional integer lattice, at time zero, place nodes on each site independently with probability $\rho \in [0,1)$ and let them evolve as a simple symmetric exclusion process. At time zero, place a target at the origin. The target moves only at integer times, and can move to any site that is within distance $R$ from its current position. Assume also that the target can predict the future movement of all nodes. We prove that, for $R$ large enough (depending on the value of $\rho$) it is possible for the target to avoid detection forever with positive probability. The proof of this result uses two ingredients of independent interest. First we establish a renormalisation scheme that can be used to prove percolation for dependent oriented models under a certain decoupling condition. This result is general and does not rely on the specifities of the model. As an application, we prove our main theorem for different dynamics, such as independent random walks and independent renewal chains. We also proof existence of oriented percolation for random interlacements and for its vacant set for large dimensions . The second step of the proof is a space-time decoupling for the exclusion process., Comment: 33 pages, 10 figures. New applications added and extended bibliography
- Published
- 2016
- Full Text
- View/download PDF
50. Development of a Green Polymeric Membrane for Sodium Diclofenac Removal from Aqueous Solutions
- Author
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Camila Suliani Raota, Janaina da Silva Crespo, Camila Baldasso, and Marcelo Giovanela
- Subjects
poly(vinyl alcohol) ,citric acid ,crosslinking ,statistical analysis ,physicochemical characterization ,Chemical technology ,TP1-1185 ,Chemical engineering ,TP155-156 - Abstract
Water-soluble polymers provide an alternative to organic solvent requirements in membrane manufacture, aiming at accomplishing the Green Chemistry principles. Poly(vinyl alcohol) (PVA) is a biodegradable and non-toxic polymer renowned for its solubility in water. However, PVA is little explored in membrane processes due to its hydrophilicity, which reduces its stability and performance. Crosslinking procedures through an esterification reaction with carboxylic acids can address this concern. For this, experimental design methodology and statistical analysis were employed to achieve the optimal crosslinking conditions of PVA with citric acid as a crosslinker, aiming at the best permeate production and sodium diclofenac (DCF) removal from water. The membranes were produced following an experimental design and characterized using multiple techniques to understand the effect of crosslinking on the membrane performance. Characterization and filtration results demonstrated that crosslinking regulates the membranes’ properties, and the optimized conditions (crosslinking at 110 °C for 110 min) produced a membrane able to remove 44% DCF from water with a permeate production of 2.2 L m−2 h−1 at 3 bar, comparable to commercial loose nanofiltration membranes. This study contributes to a more profound knowledge of green membranes to make water treatment a sustainable practice in the near future.
- Published
- 2023
- Full Text
- View/download PDF
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