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This is a descriptive, cross*sectional, nonexperimental study of 76 newborn children (NB) (Maternity and Children Hospital Jose Maria Vargas, Valencia, Venezuela): 40 of them were delivered by mothers with allergy history and 36 without these antecedents. We quantified serum CD23s, IgE and the number of CD23m (+) B lymphocytes in the umbilical chord blood and these results were correlated with pregnancy exposure to house dust. CD23s - serum IgE was assayed by ELISA (Smartest Diagnostics). CD23m (blood) by flow cytometer Becton-Dickinson FACScan. Maternal age of total group (mean ± SD): 21.65 ± 4.88 years old. Male NB babies were 40.8%. Exposure to dust during pregnancy accounted for 81.6% and 40 NB had associated a maternal history of allergy (+). In total group: CD23s was 648 ± 248.6 pg / ml, 5.5 ± 9.7 IU IgE / mL, B lymphocytes CD23m (+): 316 ± 189.7 cells / uL. CD23s: NB with maternal history of allergy (+): 727.6 ± 291.7 pg / mL NB from mothers with no history: 561 43 ± 1504 pg / mL (p = 0.0012). CD23m in NB from mothers with history: 294 ± 1472 cells / uL. NB in mothers without allergy antecedents: 340.5 ± 227.6 cells / uL (p = 0.14), No statistical correlation was found between: CD23m and CD23s with IgE (total group). Maternal history of atopy and possible intrauterine sensitization process appears to be associated with elevated levels of CD23s in newborn babies. [ABSTRACT FROM AUTHOR]

Background: Adrenal gland involvement by metastatic melanoma can be found in up to 50% of patients with ocular or cutaneous melanomas. Since these tumors are not hormone secreting, they usually present with locally advanced disease., Case: We report on the presence of a bilateral massive metastatic adrenal melanoma in an 80-year-old, symptomatic woman with the initial clinical diagnosis of adrenal hemorrhage/carcinoma. Histological assessment of the bilateral adrenalectomy showed a massive malignant melanoma in the adrenal glands, consistent with metastasis. Following that diagnosis, thorough studies revealed no ocular, mucocutaneous or primary tumor. The presence of melanoma in both adrenal glands favors metastatic melanoma over a primary adrenal melanoma., Conclusion: What makes this case rare is the unusually great size of the symptomatic bilateral malignant melanoma adrenal metastasis of occult primary with wide hemorrhagic and necrotic areas, which was probably responsible for the patient's acute symptoms. The search for the primary tumor may be exigent, and it might not even be present at the time of diagnosis. Confirmation at autopsy is advisable, however this may not always be feasible.