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1. Profiling of Serum Oxylipins During the Earliest Stages of Rheumatoid Arthritis

Author

Rodríguez‐Carrio, Javier, Coras, Roxana, Alperi‐López, Mercedes, López, Patricia, Ulloa, Catalina, Ballina‐García, Francisco Javier, Armando, Aaron M, Quehenberger, Oswald, Guma, Mónica, and Suárez, Ana

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Rheumatoid Arthritis, Arthritis, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Adult, Aged, Antirheumatic Agents, Arthritis, Rheumatoid, Case-Control Studies, Discriminant Analysis, Disease Progression, Female, Humans, Least-Squares Analysis, Male, Middle Aged, Oxylipins, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectiveEicosanoids modulate inflammation via complex networks involving different pathways and downstream mediators, including oxylipins. Although altered eicosanoids are linked to rheumatoid arthritis (RA), suggesting that metabolization is enhanced, the role of oxylipins in disease stratification remains unexplored. This study was undertaken to characterize oxylipin networks during the earliest stages of RA and evaluate their associations with clinical features and treatment outcomes.MethodsIn total, 60 patients with early RA (according to the American College of Rheumatology/European League Against Rheumatism 2010 criteria), 11 individuals with clinically suspect arthralgia (CSA), and 28 healthy control subjects were recruited. Serum samples were collected at the time of onset. In the early RA group, 50 patients who had not been exposed to disease-modifying antirheumatic drug (DMARD) or glucocorticoid treatment at the time of recruitment were prospectively followed up at 6 and 12 months after having received conventional synthetic DMARDs. A total of 75 oxylipins, mostly derived from arachidonic, eicosapentanoic, and linoleic acids, were identified in the serum by liquid chromatography tandem mass spectrometry.ResultsUnivariate analyses demonstrated differences in expression patterns of 14 oxylipins across the RA, CSA, and healthy control groups, with each exhibiting a different trajectory. Network analyses revealed a strong grouping pattern of oxylipins in RA patients, whereas in individuals with CSA, a fuzzy network of oxylipins with higher degree and closeness was found. Partial least-squares discriminant analyses yielded variable important projection scores of >1 for 22 oxylipins, which allowed the identification of 2 clusters. Cluster usage differed among the groups (P = 0.003), and showed associations with disease severity and low rates of remission at 6 and 12 months in RA patients who were initially treatment-naive. Pathway enrichment analyses revealed different precursors and pathways between the groups, highlighting the relevance of the arachidonic acid pathway in individuals with CSA and the lipooxygenase pathway in patients with early RA. In applying distinct oxylipin signatures, subsets of seropositive and seronegative RA could be identified.ConclusionOxylipin networks differ across stages during the earliest phases of RA. These distinct oxylipin networks could potentially elucidate pathways with clinical relevance for disease progression, clinical heterogeneity, and treatment response.

Published
2021

6. Quality of Care Standards for Nursing Clinics in Rheumatology

Author

Muñoz Fernández, Santiago, Lázaro y De Mercado, Pablo, Alegre López, Javier, Almodóvar González, Raquel, Alonso Ruiz, Alberto, Ballina García, Francisco Javier, Bilbao Cantarero, Ana María, Cabañas Sáenz, Mercedes, García-Vicuña, Rosario, Mínguez Vega, Mauricio, Padró Blanch, Isabel, Román Ivorra, José Andrés, and Roncal Marqueta, Encarnación

Published
2013
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7. Estándares de calidad asistencial para las consultas de enfermería en reumatología

Author

Muñoz Fernández, Santiago, Lázaro y De Mercado, Pablo, Alegre López, Javier, Almodóvar González, Raquel, Alonso Ruiz, Alberto, Ballina García, Francisco Javier, Bilbao Cantarero, Ana María, Cabañas Sáenz, Mercedes, García-Vicuña, Rosario, Mínguez Vega, Mauricio, Padró Blanch, Isabel, Román Ivorra, José Andrés, and Roncal Marqueta, Encarnación

Published
2013
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9. Profiling of Serum Oxylipins During the Earliest Stages of Rheumatoid Arthritis.

Author

Rodríguez-Carrio, Javier, Rodríguez-Carrio, Javier, Coras, Roxana, Alperi-López, Mercedes, López, Patricia, Ulloa, Catalina, Ballina-García, Francisco Javier, Armando, Aaron M, Quehenberger, Oswald, Guma, Mónica, Suárez, Ana, Rodríguez-Carrio, Javier, Rodríguez-Carrio, Javier, Coras, Roxana, Alperi-López, Mercedes, López, Patricia, Ulloa, Catalina, Ballina-García, Francisco Javier, Armando, Aaron M, Quehenberger, Oswald, Guma, Mónica, and Suárez, Ana

Abstract

ObjectiveEicosanoids modulate inflammation via complex networks involving different pathways and downstream mediators, including oxylipins. Although altered eicosanoids are linked to rheumatoid arthritis (RA), suggesting that metabolization is enhanced, the role of oxylipins in disease stratification remains unexplored. This study was undertaken to characterize oxylipin networks during the earliest stages of RA and evaluate their associations with clinical features and treatment outcomes.MethodsIn total, 60 patients with early RA (according to the American College of Rheumatology/European League Against Rheumatism 2010 criteria), 11 individuals with clinically suspect arthralgia (CSA), and 28 healthy control subjects were recruited. Serum samples were collected at the time of onset. In the early RA group, 50 patients who had not been exposed to disease-modifying antirheumatic drug (DMARD) or glucocorticoid treatment at the time of recruitment were prospectively followed up at 6 and 12 months after having received conventional synthetic DMARDs. A total of 75 oxylipins, mostly derived from arachidonic, eicosapentanoic, and linoleic acids, were identified in the serum by liquid chromatography tandem mass spectrometry.ResultsUnivariate analyses demonstrated differences in expression patterns of 14 oxylipins across the RA, CSA, and healthy control groups, with each exhibiting a different trajectory. Network analyses revealed a strong grouping pattern of oxylipins in RA patients, whereas in individuals with CSA, a fuzzy network of oxylipins with higher degree and closeness was found. Partial least-squares discriminant analyses yielded variable important projection scores of >1 for 22 oxylipins, which allowed the identification of 2 clusters. Cluster usage differed among the groups (P = 0.003), and showed associations with disease severity and low rates of remission at 6 and 12 months in RA patients who were initially treatment-naive. Pathway enrichment analyses reveale

Published
2021

12. A Genome-Wide Association Study Identifies rs116199914 As an Intergenic Variant Associated with Carotid Intima-Media Thickness in Spanish Patients with Rheumatoid Arthritis

Author

López-Mejías, Raquel, Genre, Fernanda, Remuzgo-Martínez, Sara, Carmona, David, Pulito-Cueto, Verónica, González-Juanatey, Carlos, Corrales, Alfonso, Vicente, Esther, Miranda-Filloy, J. A., Segura Tejera, Beatriz, Ramírez Huaranga, Marco A., Mijares, Verónica, Lera-Gómez, Leticia, Blanco, Ricardo, Robustillo-Villarino, Montserrat, Rodríguez-Carrio, Javier, Suárez, Ana, Alperi-López, Mercedes, Ballina García, Francisco Javier, López Longo, Francisco Javier, Narváez, Francisco Javier, Alegre, Juan José, Mera, Antonio, Perez Pampín, Eva, González, Antonio, Raya Álvarez, Enrique, López-Pedrera, Chary, Gómez Vaquero, Carmen, Balsa, Alejandro, Pascual-Salcedo, Dora, Carreira, P., González-Álvaro, Isidoro, Rodríguez Rodríguez, Luis, Fernández Gutiérrez, Benjamín, Ferraz-Amaro, Iván, Castañeda, Santos, Martín, J., Llorca, Javier, and González-Gay, M. A.

Published
2018

16. AB0779 TOWARDS A GLOBAL MANAGEMENT OF PSORIATIC ARTHRITIS: ESTIMATION OF THE CARDIOVASCULAR RISK AND THE ACTIVITY OF THE DISEASE IN CLINICAL PRACTICE

Author

Lorenzo Martín, José andrés, primary, Campo, Estefania Pardo, additional, Martínez, Marina Pino, additional, Charca Benavente, Lilian Consuelo, additional, Arboleya Rodríguez, Luis Marcelino, additional, Castro, Sara alonso, additional, Alperi-López, Mercedes, additional, Ballina-García, Francisco Javier, additional, and Silva, Rubén Queiró, additional

Published
2019
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18. Paraoxonase 1 Activity Is Modulated by the rs662 Polymorphism and IgG Anti-High-Density Lipoprotein Antibodies in Patients with Rheumatoid Arthritis: Potential Implications for Cardiovascular Disease

Author

Rodríguez Carrio, Javier, López Mejías, Raquel, Alperi López, Mercedes, López Suárez, Patricia, Ballina García, Francisco Javier, González Gay, Miguel Ángel, and Suárez Díaz, Ana María

Abstract

Supported in part by funds from the European Union FEDER, the Fondo de Investigación Sanitaria (grants PI12/00523 and PI12/00060 from the Instituto de Salud Carlos III, Spanish Ministry of Health), and a RETICS program grant (RD12/0009 from the Instituto de Salud Carlos III, Spanish Ministry of Health). Dr. Rodríguez-Carrio’s work was supported by an FPU fellowship from the Spanish Ministry of Education (AP2010-1614). Dr. López-Mejías is recipient of a Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III at the Spanish Ministry of Health (CD12/00425).

Published
2016

20. HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis

Author

Queiro Silva, Rubén, González Rodríguez, Segundo, López Larrea, Carlos, Alperi López, Mercedes, Sarasqueta Eizaguirre, Cristina, Riestra Noriega, José Luis, and Ballina García, Francisco Javier

Subjects
Male, Arthritis, Psoriatic, Humans, Female, Genetic Predisposition to Disease, HLA-C Antigens, Middle Aged, Polymerase Chain Reaction, Alleles, HLA-B27 Antigen, Research Article
Abstract

The aim of the present study was to evaluate the relative contribution of human leukocyte antigen (HLA)-C locus alleles in determining the risk and the clinical expression of psoriatic arthritis (PsA). One hundred PsA patients were randomly selected and grouped into three disease subsets: oligoarthritis (n = 40), polyarthritis (n = 25) and spondylitis (n = 35). The HLA-C locus profile of this cohort was studied by methods based on molecular biology and was compared with that of 45 patients with psoriasis vulgaris and 177 healthy blood donors from the same ethnic origin. HLA-Cw*0602 was found associated with both psoriasis (odds ratio (OR) 6.2; 95% confidence interval (CI) 3.1 to 12.5; p < 0.0001) and PsA (OR 6.2; 95% CI 3.6 to 10.8; p < 0.0001); however, this allele was equally found among the PsA subsets. HLA-Cw6-positive patients showed a longer psoriasis-arthritis latency period (p = 0.012). HLA-Cw*0701 was found under-represented in PsA in comparison with controls (OR 0.5; 95% CI 0.3 to 0.9; p = 0.04), as was HLA-Cw*0802 (OR 0.3; 95% CI 0.08 to 1; p = 0.05). A positive association was found between psoriatic spondylitis and HLA-Cw*0702 (OR 5.0; 95% CI 1.4 to 25; p = 0.01). HLA-Cw*0602 seems to confer a general risk for psoriasis, but the presence of other HLA-C locus alleles may explain an additional arthritogenic risk. HLA-C alleles may modulate some aspects of the clinical expression of PsA, but these findings need confirmation.

Published
2006

21. Antibodies to paraoxonase 1 are associated with oxidant status and endothelial activation in rheumatoid arthritis.

Author

Rodríguez-Carrio, Javier, Alperi-López, Mercedes, López-Mejías, Raquel, López, Patricia, Ballina-García, Francisco Javier, Abal, Francisco, González-Gay, Miguel Ángel, and Suarez, Ana

Subjects
RHEUMATOID arthritis treatment, IMMUNOGLOBULINS, PARAOXONASE, OXIDANT status, ENDOTHELIAL cells
Abstract

Traditional and non-traditional cardiovascular (CV) risk factors underlie CV disease occurrence in rheumatoid arthritis (RA). Recently, a functional impairment of high-density lipoprotein (HDL) has been observed. Although the actual players are unknown, anti-HDLs were associated with altered lipid profile, decreased paraoxonase 1 (PON1) activity and CV disease in RA. Therefore, we aimed to evaluate whether the presence of antibodies against PON1 may be involved in this scenario. IgG anti-PON1 antibodies were quantified by ELISA in serum samples from 212 RA patients, 175 healthy controls (HC) and 54 subjects with traditional CV risk factors (CVR). A subgroup of 13 RA patients was prospectively followed upon tumour necrosis factor-α (TNFα) blockade. Serum PON1 activity, nitric oxide (NO) and total antioxidant capacity (TAC) were measured. Interferon-γ (IFNγ), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule (sICAM) and TNFα serum levels were assessed by immunoassays. PON1 rs662 (Q > R) status was studied by reverse transcription (RT)-PCR. IgG anti-PON1 antibodies are increased in RA patients compared with HC (P<0.0001) and CVR subjects (P<0.001), even after correcting for total IgG levels. Although no associations with lipid profile were found, a positive correlation with Health Assessment Questionnaire (HAQ) was observed (r =0.215, P=0.004). Anti-PON1 antibodies were associated with PON1 activity, NO and TAC, a rs662-mediated gene-dosage effect being found. Similarly, anti-PON1 antibodies were associated with sICAM serum levels in univariate and multivariate models. Finally, these antibodies were not affected by TNFα blockade. Anti-PON1 antibodies can be responsible for PON1 impairment in RA patients, with a potential impact on biomarkers of oxidative status and endothelial activation. A gene-environment interaction of rs662 variants is supported. [ABSTRACT FROM AUTHOR]

Published
2016
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23. Colaboradores

Author

Abalovich, Marcos S., Agustí García-Navarro, Álvaro, Agustí García-Navarro, Carlos, Albanell Mestres, Joan, Alcalá Hernández, Luis, Alcaraz Asensio, Antonio, Alcázar Arroyo, Roberto, Alegre de Miquel, Víctor, Alexandra Hanzu, Felicia, Almirante Gragera, Benito, Alonso Tarrés, Carles, Alsina Gibert, Mercè, Alsina Manrique de Lara, Laia, Álvarez Martínez, Miriam José, Álvarez-Sala Walther, José Luis, Ambrosioni Czyrko, Juan, Ancochea Bermúdez, Julio, Andrade Bellido, Raúl J., Antón López, Jordi, Aran Perramon, Josep Maria, Arance Fernández, Ana, Arboleya Rodríguez, Luis, Arellano Tolivar, Antonio, Arias Gómez, Manuel, Arias Loste, M.ª Teresa, Ariza Cardenal, Javier, Armengol Dulcet, Lluís, Aróstegui Gorospe, Juan Ignacio, Arrese, Marco, Arroyo Pérez, Vicente, Aschner Montoya, Pablo, Audí Parera, Laura, Azpiroz Vidaur, Fernando, Badimon Maestro, Lina, Baena Caparrós, Jacinto, Ballester Rodés, Eugenio, Ballina García, Francisco Javier, Barberà Mir, Joan Albert, Barberán López, José, Barile Fabris, Leonor, Bartra Tomás, Joan, Bassas Arnau, Lluís, Bassat Orellana, Quique, Bataller Alberola, Luis, Bayés Colomer, Mónica, Bernardo Arroyo, Miquel, Berraondo López, Pedro, Bielsa Marsol, Isabel, Bladé Creixentí, Joan, Blancafort Sansó, Xavier, Blanco Arévalo, José Luis, Blanco García, Francisco J., Blanes Mompó, José Ignacio, Blesa González, Rafael, Bodegas Cañas, Andrés Ignacio, Bodro Marimont, Marta, Boronat Guerrero, Susana, Bosch Albareda, Francesc, Bosch Genover, Jaime, Bosch Genover, Xavier, Bosch Gil, José Ángel, Bosch Mestres, Jordi, Botey Puig, Albert, Bouza Santiago, Emilio, Bru Saumell, Concepció, Brugada Terradellas, Josep, Brugada Terradellas, Ramon, Bruguera Cortada, Miquel, Bruix Tudó, Jordi, Bujanda Fernández de Piérola, Luis, Buti Ferret, María, Caballería Rovira, Joan, Cabellos Mínguez, Carmen, Cahn, Pedro, Calvet Calvo, Xavier, Calzado Isbert, Sonia, Campins Martí, Magda, Campistol Plana, Josep M.ª, Campo Casanelles, Miguel del, Campo Güerri, Elías, Campuzano Larrea, Óscar, Campuzano Uceda, Victoria, Cardellach López, Francesc, Carmena Rodríguez, Rafael, Carmona Herrera, Francisco, Carracedo Álvarez, Ángel, Carrascosa Lezcona, Antonio, Carreres Molas, Anna, Carreras Pons, Enric, Casabona i Barbarà, Jordi, Casademont Pou, Jordi, Casanueva, Felipe F., Cases Amenós, Aleix, Castells Garangou, Antoni, Castro Fornieles, Josefina, Castro Rebollo, Pedro, Catalán Eraso, Beatriz, Caylà Buqueras, Joan A., Cervantes Requena, Francisco, Cervera Segura, Ricardo, Cervera Álvarez, Carlos, Chamorro Sánchez, Ángel, Cinta Cid Xutglà, María, Cinca Cuscullola, Juan M.ª, Coll Daroca, Joaquím, Coll Rosell, M.ª José, Colmenero Arroyo, Jordi, Conesa Bertrán, Gerardo, Corell Almuzara, Alfredo, Crespo Casal, Manuel, Crespo Conde, Gonzalo, Crespo García, Javier, Cristòfol Allué, Ramon, Cubiella Fernández, Joaquín, Cuenca Estrella, Manuel, Dalmau Obrador, Josep, Davant Llauradó, Ester, Delgado González, Julio, Desola Alà, Jordi, Diekmann, Fritz, Dolz Abadía, Carlos, Domínguez Benítez, José Antonio, Domínguez García, Ángela, Domínguez Luengo, Carmen, Domínguez Luzón, M.ª Ángeles, Domínguez Tordable, M.ª Jesús, Dopazo Blázquez, Joaquín, Dueñas Laita, Antonio, Durán Rebolledo, Carlos Eduardo, Duró Pujol, Juan Carlos, Echevarría Mayo, José Manuel, Echevarria Mayo, Juan Emilio, Eiros Bouza, José M.ª, Elizalde Frez, José Ignacio, Engel Rocamora, Pablo, Enrique Cahn, Pedro, Enríquez de Salamanca Lorente, Rafael, Escorsell Mañosa, Àngels, Escribano Mora, Luis, Estapé Madinabeitia, Tania, Estapé Rodríguez, Jordi, Esteban Mur, Rafael, Esteller Badosa, Manel, Esteve Comas, María, Esteve Pardo, María, Esteve Reyner, Jordi, Estivill Pallejà, Xavier, Estruch Riba, Ramón, Fainboim, Leo, Feliu Frasnedo, Evarist, Fernández Bañares, Fernando, Fernández Fernández, Óscar, Fernández Gómez, Javier, Fernández-Tresguerres Hernández, Jesús Ángel, Ferrándiz Foraster, Carlos, Ferrer Monreal, Miguel, Figuerola Pino, Daniel, Fillat Fonts, Cristina, Fonollosa Pla, Vincent, Fonseca Capdevila, Eduardo, Font Creus, Bernat, Fontanellas Romá, Antonio, Forns Bernhardt, Xavier, Fortuny Guasch, Claudia, Franco de Castro, Agustín, Franco Vásquez, José G., Fresno Escudero, Manuel, Galarza Delgado, Dionicio Ángel, Galicia Paredes, Miguel, Gállego Culleré, Montserrat, Gallego García de Vinuesa, Pastora, Gárate Ormaechea, Teresa, García Lareo, Manuel, Carlos García Moncó, Juan, García Nieto, Víctor M., García-Pagán, Juan Carlos, García Sánchez, José Elías, García-Zepeda, Eduardo Alberto, Garrido Marín, Eduardo, Gascón Brustenga, Joaquim, Gatell Artigas, Josep M.ª, Gaztambide Sáenz, Sonia, Giavina-Bianchi, Pedro, Gil de Extremera, Blas, Giménez Pérez, Montserrat, Ginès Gibert, Pere, Girós Blasco, M.ª Luisa, Goday Arnó, Albert, Gómez Dantés, Héctor, Gómez Gil, Esther, Gómez Junyent, Joan, Gómez Sáez, José Manuel, Gómez-Batiste Alentorn, Xavier, Gomollón García, Fernando, González Argenté, Francesc Xavier, González Juanatey, José Ramón, González Macías, Jesús, González Martín, Julià, González Tugas, Matías, Gonzalo de Liria, Carlos Rodrigo, Gracia Guillén, Diego, Gracia Roldán, Javier de, Grau Junyent, Josep M.ª, Grau de Castro, Juan José, Graus Ribas, Francesc, Gual Solé, Antoni, Guañabens Gay, Núria, Guardiola Ponti, Helena, Gurguí Ferrer, Mercè, Gutiérrez Julián, José M.ª, Gutiérrez Ponce de León, Fernando, Halperin Rabinovich, Irene, Hawkins Carranza, Federico G., Hernández García, Miguel T., Hernández-Nieto, Luis, Herrero Santos, José Ignacio, Ibáñez Toda, Lourdes, Illa Sendra, Isabel, Iranzo de Riquer, Alejandro, Jaraquemada Pérez de Guzmán, Dolores, Jové Teixidó, Josep, Juan Otero, Manel, Juanola Roura, Xavier, Kalil, Jorge, Khamashta, Munther, Labarca Labarca, Jaime, Laborde, Amalia, Lanas Arbeloa, Ángel, Larrosa Escartín, Nieves, Liñares Louzao, Josefina, Lobo Satué, Antonio, Londoño, María Carlota, López Bernaldo de Quirós, Juan Carlos, López Guillermo, Armando, López Otín, Carlos, Luis López-Sendón, José, López-Vélez Pérez, Rogelio, Lozano Sánchez, Francisco S., Lozano Soto, Francisco, Lucas Martín, Anna M.ª, Lucas Morante, Tomás, Luis Alonso, Pedro, Lumbreras Bermejo, Carlos, Madaria Pascual, Enrique de, Mallolas Masferrer, Josep, Mañá Rey, Juan, Marcas Vila, Álex, Marco Reverté, Francesc David, Marcos Maeso, M.ª Ángeles, Marrades Sicart, Ramón M.ª, Marruecos Sant, Lluís, Marrugat de la Iglesia, Jaume, Martín Sierra, Cristina, Martínez Díaz-Guerra, Guillermo, Martínez Martínez, José Antonio, Martínez Vea, Alberto, Martínez Yélamos, Sergio, Martínez Yoldi, Miguel J., Martorell Pons, Jaume, Mas Capó, Jordi, Mas Ordeig, Antoni, Masana Marín, Lluís, Masana Montejo, Guillem, Manuel Mascaró Galy, José, Matas Andreu, Lurdes, Maurel, Joan, Melero, Marcelo José, Melero Bermejo, Ignacio, Mellado González, Begoña, Mensa Pueyo, José, Mercé Klein, Jordi, Mestres Alomar, Gaspar, Milà Recasens, Monteserrat, Miquel Abbad, Carlos, Miralles Basseda, Ramón, Miralles Hernández, Manuel, Miró Meda, José M.ª, Mòdol Deltell, Josep M.ª, Molero Richard, Xavier, Molina Infante, Javier, Molins López-Rodó, Laureano, Mont Girbau, Lluís, Montoro Huguet, Miguel Ángel, Montserrat Canal, Josep M.ª, Morales-Olivas, Francisco José, Morán Chorro, Indalecio, Morata Ruiz, Laura, Morell Brotad, Ferran, Moreno Camacho, M.ª Asunción, Moreno Carriles, Rosa M.ª, Moreno Ramírez, David, Muñoz García, José Esteban, Muñoz García-Paredes, Patricia, Muñoz Gutiérrez, José, Muñoz Mateu, Montserrat, Muñoz Villegas, Álvaro, Muxí Pradas, M.ª África, Navarro Acebes, Xavier, Navasa Anadón, Miquel À., Nicolás Arfelis, José M.ª, Nogué Xarau, Santiago, Nolla Sañas, Joan, Miquel Nolla Solé, Joan, Norman, Francesca F., Obach Baurier, Victor, Obrador Vera, Gregorio Tomás, Oliva Dámaso, Elena, Olivé Marqués, Alejandro, Ordi Ros, José, Ortiz Arduan, Alberto, Ortiz de Lejarazu Leonardo, Raúl, Ortiz Rivera, Marta, Oteo Revuelta, José Antonio, Pablo Rabassó, Joan de, Palau Martínez, Francesc, Pallarés Giner, Román, Palou Rivera, Eduardo, Panés Díaz, Julià, Paré Bardera, Joan Carles, Parés Darnaculleta, Albert, Parrilla Paricio, Pascual, Pascal Capdevila, Mariona, Pascual Gómez, Eliseo, Pascual Gómez, Julio, Pedro-Botet Montoya, Juan, Pedro-Botet Montoya, M.ª Luisa, Pereira Saavedra, Arturo, Pérez Gisbert, Javier, Pérez Jurado, Luis Alberto, Pérez Sáenz, José Luis, Pérez Trallero, Emilio, Picado Vallés, César, Picado de Puig, Albert, Picó Alfonso, Antonio, Pigrau Serrallach, Carlos, Pinazo Delgado, M.ª Jesús, Pintado García, Vicente, Pintos Morell, Guillem, Piñeiro Ibáñez, Daniel José, Poch López de Briñas, Esteban, Pons Lladó, Guillem, Pons-Estel, Bernardo A., Pons-Estel, Guillermo J., Porcel Pérez, José Manuel, Portela Hernández, Margarita, Praga Terente, Manuel, Prat, Aleix, Puig Domingo, Manuel, Pujol Borrell, Ricardo, Pulido Mestre, Marta, Pumarola Suñé, Tomàs, Puras Mallagray, Enrique, Quintana Porras, Luis F., Quintero Carrión, Enrique, Rabinovich, Gabriel A., Rabionet Janssen, Raquel, Ramos Casals, Manuel, Real Arribas, Francisco X., Rego Castro, M.ª José, Reguart, Noemi, Regueiro González, José R., Reverter Calatayud, Jordi Lluís, Reverter Calatayud, Juan Carlos, Rey-Joly Barroso, Celestino, Reyes, José Miguel, Reynals de Blasis, Enrique, Riambau Alonso, Vicente, Ribera Casado, José Manuel, Ribera Santasusana, Josep M.ª, Ribes Rubió, Antonia, Rimola Castellá, Antoni, Río Bueno, Ana del, Robert Boter, Neus, Roca Antònio, Josep, Roca Torrent, Josep, Rodés Teixidor, Joan, Rodríguez Baño, Jesús, Rodríguez de Castro, Felipe, Rodríguez Panadero, Francisco, Rodríguez Pérez, José Carlos, Rodríguez Roisin, Roberto, Roig Minguell, Eulàlia, Rojas García, Ricardo, Romero Gómez, Manuel, Rovira Cañellas, Àlex, Rozman Borstnar, Ciril, Rozman Jurado, María, Ruiz Granell, Ricardo, Ruiz Manzano, Juan, Ruiz Moreno, Javier, Ruiz-Argüelles, Guillermo José, Sabaté Tenas, Manuel, Saiz Hinarejos, Albert, Salgado García, Emilio José, Salinas Vert, Isabel, San Miguel, Jesús F., Sánchez González, Marcelo, Sánchez Rodríguez, Ángel, Sánchez Tapias, José M.ª, Sanmartí Sala, Raimon, Santamaria Cano, Joan, Sanz Alonso, Miguel Ángel, Sanz Santillana, Guillermo F., Saperas Franch, Esteban, Segura Egea, Antonia, Segura Porta, Ferrán, Selva O’Callaghan, Albert, Serra Majem, Lluís, Sierra Gil, Jorge, Sierra Iserte, Alejandro de la, Sierra Romero, Gustavo Adolfo, Sitges Carreño, Marta, Solà Vergés, Elsa, Solana Lara, Rafael, Solans Laqué, Roser, Soldevila Melgarejo, M.ª Gloria, Sopena Galindo, Nieves, Soriano Viladomiu, Álex, Soy Muner, Dolors, Targarona Soler, Eduardo M.ª, Tejedor Jorge, Alberto, Tena Marsà, Xavier, de Teresa Galván, Eduardo, Tolosa Sarró, Eduardo, Tornero Molina, Jesús, Tornos Mas, Pilar, Torra Balcells, Roser, Torre Cisneros, Julián de la, Torregrosa Prats, José Vicente, Torres Hortal, Montserrat, Torres Martí, Antonio, Torres Ramírez, Armando, Torrico, Faustino, Trilla García, Antoni, Tuca Rodríguez, Albert, Tudela Hita, Pere, Urbano Ispizua, Álvaro, Urrutia de Diego, Agustín, Valdés Miyar, Manuel, Valls Lolla, M.ª Eugenia, Valls Solé, Josep, Vaquero Raya, Eva C., Vázquez Martínez, Clotilde, Vázquez Zaragoza, Miguel Ángel, Verea Hernando, Héctor, Vicente García, Vicente, Vidal Bermúdez, José E., Vidal-Puig, Antonio, Vieta Pascual, Eduardo, Vila Estapé, Jordi, Vilar, Eduardo, Vilardell Tarrés, Miguel, Vilella Morató, Anna, Villabona Artero, Carlos, Villamor Casas, Neus, Vinuesa Aumedes, Teresa, Viñolas, Nuria, Vives Corrons, Joan Lluís, Webb Youdale, Susan M., Xaubet Mir, Antonio, Yagüe Ribes, Jordi, and Zarranz Imirizaldu, Juan José

Published
2016
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24. Autores

Author

Abecia Inchaurregui, Luis Carlos, Abreu Rodríguez, Rossana, Aguinaga Ontoso, Enrique, Aibar Remón, Carlos, Alberdi Sudupe, Jesús, Alfonso Sánchez, José Luis, Alguacil Ojeda, Juan, Almaraz Gómez, Ana, Altet Gómez, María Neus, Álvarez Marante, Roberto, Álvarez-Dardet Díaz, Carlos, Álvarez-Ruiz, Juan Carlos, Amezcua Prieto, Carmen, Aranaz Andrés, Jesús M.ª, Aranceta Bartrina, Javier, Arcos González, Pedro, Arévalo Morales, M.ª Pilar, Arias Rodríguez, Ángeles, Armadans Gil, Lluís, Badenier Bustamante, Osvaldo, Ballina García, Francisco Javier, Baltar Trabazo, José Manuel, Banegas Banegas, José Ramón, Barros Dios, Juan Miguel, Bes-Rastrollo, Maira, Bolúmar Montrull, Francisco, Borràs López, Eva, Brugos Larumbe, Antonio, Bueno Cavanillas, Aurora, Caamaño Isorna, Francisco, Calle Purón, María Elisa, Calleja Cabeza, Patricia, Campayo Rojas, Francisco Javier, Campins Martí, Magda, Carlos Chillerón, Silvia, Carrasco Garrido, Pilar, Castro Delgado, Rafael, Castro Hernández, Beatriz, Conde Herrera, Manuel, Corella Piquer, Dolores, Cores Calvo, Juan, Crous Bou, Marta, Davó Blanes, M.ª Carmen, de Irala Estévez, Jokin, de Juanes Pardo, José Ramón, del Barrio Fernández, José Luis, del Rey Calero, Juan, Delgado Rodríguez, Miguel, Díaz Molina, Carmen, Dierssen Sotos, Trinidad, Díez Sebastián, Jesús, Díez-Gañán, Lucía, Domínguez García, Ángela, Domínguez Rojas, Vicente, Donat-Vargas, Carolina, Doreste Alonso, Jorge Luis, Duran Jordà, Xavier, Escribá Aguir, Vicenta, Esguep Sarah, Alfredo, Espigares García, Miguel, Espigares Rodríguez, Elena, Farouk Allam, Mohamed, Fernández Muñoz, Esteve, Fernández-Crehuet Navajas, Joaquín, Fernández-Crehuet Navajas, Rafael, Fernández-Crehuet Serrano, José Luis, Fernández-Crehuet Serrano, Pablo, Ferreira Herdeiro, María Teresa, Figueiras Guzmán, Adolfo, Fuentes Almendras, Margarita, Gallardo Pino, Carmen, García Barbero, Milagros, García Benavides, Fernando, García Caballero, Juan, García de la Hera, Manuela, García López, Eva María, García Martín, Miguel, García Rodríguez, Antonio, Gea Sánchez, Alfredo, Gestal Otero, Juan Jesús, Gestal Romaní, Santiago, Gil de Miguel, Ángel, Gil Prieto, Ruth, Gil-González, Diana, Gili Miner, Miguel, Gómez Acebo, Inés, Gómez-Aracena, Jorge, Gómez-Gracia, Enrique, González Iglesias, Marta Clara, Graciani Pérez-Regadera, Auxiliadora, Guallar Castillón, Pilar, Guillén Grima, Francisco, Guillén Solvas, José Francisco, Gutiérrez Bedmar, Mario, Gutiérrez-Fisac, Juan Luis, Harris, Meggan, Henríquez Sánchez, Patricia, Hernández Aguado, Ildefonso, Hernández Mejía, Radhamés, Herruzo Cabrera, Rafael, Herruzo Priego, Irene, Iglesias Amorín, José Luis, Jiménez García, Rodrigo, Jiménez Mejías, Eladio, Jiménez Moleón, José Juan, Jurado Chacón, Dolores, Lana Pérez, Alberto, Lardelli Claret, Pablo, Latorre-Arteaga, Sergio, Lecuona Fernández, María, Llinás Santacreu, Gilberto, Llopis González, Agustín, Llorca Díaz, Javier, López de Andrés, Ana, López García, Esther, López-Gigosos, Rosa María, López González, María Luisa, López Jurado, Lázaro, López-del Burgo, Cristina, Lumbreras Lacarra, Blanca, Luna del Castillo, Juan de Dios, Malvar Pintos, Alberto, Mariscal Larrubia, Alberto, Martín Moreno, José María, Martín Sánchez, Vicente, Martín-Calvo, Nerea, Martínez-González, Miguel Ángel, Martínez Ruiz, Virginia, Martínez Vizcaíno, Vicente, Mendiola Olivares, Jaime, Miqueleiz Autor, Estrella, Monasterio Otero, Adolfo Alejandro, Monge Corella, Susana, Montes Martínez, Agustín, Morales Suárez-Varela, María M., Moreno Abril, Obdulia, Moreno Roldán, Elena, Moya Geromini, Ángeles, Muñiz Saborido, José Ramón, Muñoz Bravo, Carlos, Navarrete Muñoz, Eva María, Olmedo Requena, Rocío, Ortiz Moncada, Rocío, Otero Cordeiro, Francisco Javier, Pastor Valero, María, Peña Sánchez de Rivera, José María, Pértega Díaz, Sonia, Pita Fernández, Salvador, Porta Serra, Miquel, Portolés Reparaz, Olga, Regidor Poyatos, Enrique, Ribas Barba, Lourdes, Río Sánchez, Isabel, Rodríguez Álvarez, Cristobalina, Rodríguez Arenas, M.ª Ángeles, Rodríguez Artalejo, Fernando, Rodríguez Cundín, Paz, Rodríguez Martínez, Marisol, Ronda Pérez, Elena, Rosell Aguilar, Ignacio, Ruano Rodríguez, Cristina, Ruiz Cantero, María Teresa, Ruiz-Canela López, Miguel, Salleras Sanmartí, Lluís, Saltó Cerezuela, Esteve, Sánchez Fernández, Luis Vicente, Sánchez Villegas, Almudena, Sastre Gervás, Isabel, Serra Majem, Lluís, Serrano del Castillo, Amparo, Sillero Arenas, María, Sorlí Guerola, José Vicente, Sotodosos Carpintero, Mercedes, Takkouche, Bahi, Taracido Trunk, Margarita, Tardón García, Adonina, Teijeiro Dacal, María José, Toledo Atucha, Estefanía A., Torner Gracia, Nuria, Torres Cantero, Alberto Manuel, Valcárcel Rivera, Yolanda, Vaqué Rafart, Josep, Villar Álvarez, Fernando, Vioque López, Jesús, and Vizcaíno Alcaide, María José

Published
2016
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25. Estudio comparativo del perfil de los factores de riesgo cardiovascular clásicos entre los pacientes con artritis psoriásica y pacientes con psoriasis

Author

Tejón Menéndez, Patricia, Ballina García, Francisco Javier, Queiro Silva, Rubén, and Medicina, Departamento de

Subjects
Reumatología
Abstract

Trabajos recientes han demostrado que la psoriasis y la artritis psoriásica (AP), al igual que otras enfermedades de base inmunológica, se asocian con una mayor prevalencia de comorbilidades cardiovasculares (CV). Esta frecuencia se asocia sólo en parte a una mayor presencia de factores de riesgo CV clásicos. Muy pocos trabajos han analizado las diferencias en la frecuencia de los factores de riesgo CV en pacientes con psoriasis sin artritis frente a aquellos con AP. OBJETIVOS 1. Analizar las diferencias en el perfil de factores de riesgo CV clásicos en pacientes con psoriasis sin artritis frente a sujetos con AP. 2. Determinar en los pacientes con AP el perfil epidemiológico y clínico que se asocia con cada uno de los eventos y factores de riesgo CV clásicos. PACIENTES Y MÉTODOS Es un estudio retrospectivo realizado en el Hospital Universitario Central de Asturias. Se incluyeron 310 pacientes con psoriasis a seguimiento por el Servicio de Dermatología y 340 pacientes de la consulta de Reumatología con el diagnóstico de AP que cumplían los criterios CASPAR. Se recogieron datos sociodemográficos, características clínicas, genéticas, radiológicas y el tratamiento recibido para dichas enfermedades. RESULTADOS Los pacientes con AP tenían mayor prevalencia de hipertensión (29.0% vs 18.5%, p=0.003) y dislipemia (27.9% vs 13.7%, p

Published
2017

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