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252 results on '"Balzarini, Piera"'

1. Concurrent RB1 and P53 pathway disruption predisposes to the development of a primitive neuronal component in high-grade gliomas depending on MYC-driven EBF3 transcription

Author

Pagani, Francesca, Orzan, Francesca, Lago, Sara, De Bacco, Francesca, Prelli, Marta, Cominelli, Manuela, Somenza, Elena, Gryzik, Magdalena, Balzarini, Piera, Ceresa, Davide, Marubbi, Daniela, Isella, Claudio, Crisafulli, Giovanni, Poli, Maura, Malatesta, Paolo, Galli, Rossella, Ronca, Roberto, Zippo, Alessio, Boccaccio, Carla, and Poliani, Pietro Luigi

Published
2025
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2. Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness

Author

Monti, Matilde, Benerini Gatta, Luisa, Bugatti, Mattia, Pezzali, Irene, Picinoli, Sara, Manfredi, Marcello, Lavazza, Antonio, Vanella, Virginia Vita, De Giorgis, Veronica, Zanatta, Lucia, Missale, Francesco, Lonardi, Silvia, Zanetti, Benedetta, Bozzoni, Giovanni, Cadei, Moris, Abate, Andrea, Vergani, Barbara, Balzarini, Piera, Battocchio, Simonetta, Facco, Carla, Turri-Zanoni, Mario, Castelnuovo, Paolo, Nicolai, Piero, Fonsatti, Ester, Leone, Biagio Eugenio, Marengo, Emilio, Sigala, Sandra, Ronca, Roberto, Perego, Michela, Lombardi, Davide, and Vermi, William

Published
2024
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4. Immunoglobulin light chain transcript detection by ultrasensitive RNA in situ hybridization for B-cell lymphoma diagnosis

Author

Lorenzi, Luisa, Lonardi, Silvia, Bonezzi, Michela, Zini, Stefania, Bugatti, Mattia, Valzelli, Arianna, Melotti, Flavia, Facchetti, Mattia, Ghini, Iacopo, Villanacci, Vincenzo, Balzarini, Piera, Pizzi, Marco, Giustini, Viviana, Galvagni, Anna, Chiarini, Marco, Dei Tos, Angelo Paolo, Vermi, William, Casola, Stefano, and Facchetti, Fabio

Published
2023
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5. Correction to: Immunoglobulin light chain transcript detection by ultrasensitive RNA in situ hybridization for B-cell lymphoma diagnosis

Author

Lorenzi, Luisa, Lonardi, Silvia, Bonezzi, Michela, Zini, Stefania, Bugatti, Mattia, Valzelli, Arianna, Melotti, Flavia, Facchetti, Mattia, Ghini, Iacopo, Villanacci, Vincenzo, Balzarini, Piera, Pizzi, Marco, Giustini, Viviana, Galvagni, Anna, Chiarini, Marco, Dei Tos, Angelo Paolo, Vermi, William, Casola, Stefano, and Facchetti, Fabio

Published
2024
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6. MYC rearrangements in HIV-associated large B-cell lymphomas: EUROMYC, a European retrospective study

Author

Pagani, Chiara, Rusconi, Chiara, Dalla Pria, Alessia, Ravano, Emanuele, Schommers, Philipp, Bastos-Oreiro, Mariana, Verga, Luisa, Gini, Guido, Spina, Michele, Arcaini, Luca, Steffanoni, Sara, Dalu, Davide, Crucitti, Lara, Lorenzi, Luisa, Balzarini, Piera, Cattaneo, Chiara, Bongiovanni, Lucia, Rosenwald, Andreas, Facchetti, Fabio, Bower, Mark, Ferreri, Andrés J. M., Rossi, Giuseppe, Tucci, Alessandra, and Re, Alessandro

Published
2024
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8. A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes

Author

Orzan, Francesca, Pagani, Francesca, Cominelli, Manuela, Triggiani, Luca, Calza, Stefano, De Bacco, Francesca, Medicina, Daniela, Balzarini, Piera, Panciani, Pier Paolo, Liserre, Roberto, Buglione, Michela, Fontanella, Marco Maria, Medico, Enzo, Galli, Rossella, Isella, Claudio, Boccaccio, Carla, Poliani, Pietro Luigi, and on behalf of the Neuro-Oncology group of Spedali Civili of Brescia

Published
2020
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10. Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness

Author

Monti, M, Benerini Gatta, L, Bugatti, M, Pezzali, I, Picinoli, S, Manfredi, M, Lavazza, A, Vanella, V, De Giorgis, V, Zanatta, L, Missale, F, Lonardi, S, Zanetti, B, Bozzoni, G, Cadei, M, Abate, A, Vergani, B, Balzarini, P, Battocchio, S, Facco, C, Turri-Zanoni, M, Castelnuovo, P, Nicolai, P, Fonsatti, E, Leone, B, Marengo, E, Sigala, S, Ronca, R, Perego, M, Lombardi, D, Vermi, W, Monti, Matilde, Benerini Gatta, Luisa, Bugatti, Mattia, Pezzali, Irene, Picinoli, Sara, Manfredi, Marcello, Lavazza, Antonio, Vanella, Virginia Vita, De Giorgis, Veronica, Zanatta, Lucia, Missale, Francesco, Lonardi, Silvia, Zanetti, Benedetta, Bozzoni, Giovanni, Cadei, Moris, Abate, Andrea, Vergani, Barbara, Balzarini, Piera, Battocchio, Simonetta, Facco, Carla, Turri-Zanoni, Mario, Castelnuovo, Paolo, Nicolai, Piero, Fonsatti, Ester, Leone, Biagio Eugenio, Marengo, Emilio, Sigala, Sandra, Ronca, Roberto, Perego, Michela, Lombardi, Davide, Vermi, William, Monti, M, Benerini Gatta, L, Bugatti, M, Pezzali, I, Picinoli, S, Manfredi, M, Lavazza, A, Vanella, V, De Giorgis, V, Zanatta, L, Missale, F, Lonardi, S, Zanetti, B, Bozzoni, G, Cadei, M, Abate, A, Vergani, B, Balzarini, P, Battocchio, S, Facco, C, Turri-Zanoni, M, Castelnuovo, P, Nicolai, P, Fonsatti, E, Leone, B, Marengo, E, Sigala, S, Ronca, R, Perego, M, Lombardi, D, Vermi, W, Monti, Matilde, Benerini Gatta, Luisa, Bugatti, Mattia, Pezzali, Irene, Picinoli, Sara, Manfredi, Marcello, Lavazza, Antonio, Vanella, Virginia Vita, De Giorgis, Veronica, Zanatta, Lucia, Missale, Francesco, Lonardi, Silvia, Zanetti, Benedetta, Bozzoni, Giovanni, Cadei, Moris, Abate, Andrea, Vergani, Barbara, Balzarini, Piera, Battocchio, Simonetta, Facco, Carla, Turri-Zanoni, Mario, Castelnuovo, Paolo, Nicolai, Piero, Fonsatti, Ester, Leone, Biagio Eugenio, Marengo, Emilio, Sigala, Sandra, Ronca, Roberto, Perego, Michela, Lombardi, Davide, and Vermi, William

Abstract

Background: Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical cellular systems has significantly limited the understanding of their immunobiology. Methods: Five novel cell lines were obtained from patient-derived biopsies of MM arising in the sino-nasal mucosa and designated as SN-MM1-5. The morphology, ultrastructure and melanocytic identity of SN-MM cell lines were validated by transmission electron microscopy and immunohistochemistry. Moreover, in vivo tumorigenicity of SN-MM1-5 was tested by subcutaneous injection in NOD/SCID mice. Molecular characterization of SN-MM cell lines was performed by a mass-spectrometry proteomic approach, and their sensitivity to PI3K chemical inhibitor LY294002 was validated by Akt activation, measured by pAkt(Ser473) and pAkt(Thr308) in immunoblots, and MTS assay. Results: This study reports the validation and functional characterization of five newly generated SN-MM cell lines. Compared to the normal counterpart, the proteomic profile of SN-MM is consistent with transformed melanocytes showing a heterogeneous degree of melanocytic differentiation and activation of cancer-related pathways. All SN-MM cell lines resulted tumorigenic in vivo and display recurrent structural variants according to aCGH analysis. Of relevance, the microscopic analysis of the corresponding xenotransplants allowed the identification of clusters of MITF-/CDH1-/CDH2 + /ZEB1 + /CD271 + cells, supporting the existence of melanoma-initiating cells also in MM, as confirmed in clinical samples. In vitro, SN-MM cell lines were sensitive to cisplatin, but not to temozolomide. Moreover, the proteomic analysis of SN-MM cell lines revealed that RICTOR, a subunit of mTORC2 complex, is the most significantly activated upstream regulator, suggesting a relevant role for the PI3K-Akt-mTOR pathway in these neoplasms. Co

Published
2024

11. Immunoglobulin light chain transcript detection by ultrasensitive RNA in situ hybridization for B-cell lymphoma diagnosis.

Author

Lorenzi, Luisa, Lonardi, Silvia, Bonezzi, Michela, Zini, Stefania, Bugatti, Mattia, Valzelli, Arianna, Melotti, Flavia, Facchetti, Mattia, Ghini, Iacopo, Villanacci, Vincenzo, Balzarini, Piera, Pizzi, Marco, Giustini, Viviana, Galvagni, Anna, Chiarini, Marco, Dei Tos, Angelo Paolo, Vermi, William, Casola, Stefano, and Facchetti, Fabio

Abstract

Evaluation of B-cell clonality can be challenging in the interpretation of lymphoid infiltrates on tissue sections. Clonality testing based on IG gene rearrangements analysis by PCR (IG-PCR) is the gold standard. Alternatively, B-cell clonality can be assessed by the recognition of immunoglobulin light chain (IgLC) restriction, by immunohistochemistry (IHC), chromogenic in situ hybridization (ISH) or flow cytometry (FC). IG-PCR requires molecular facilities, and FC requires cell suspensions, both not widely available in routine pathology units. This study evaluates the performance of B-cell clonality detection by IgLC-RNAscope® (RNAsc) in a group of 216 formalin-fixed, paraffin-embedded samples including 185 non-Hodgkin B-cell lymphomas, 11 Hodgkin lymphomas (HL) and 20 reactive samples. IgLC-RNAsc, performed in parallel with FC in 53 cases, demonstrated better performances (93% vs 83%), particularly in diffuse large B-cell lymphoma (98% vs 71%) and follicular lymphoma (93% vs 83%) diagnosis. IgLC-RNAsc was also superior to IHC and ISH especially in samples with limited tumor cell content, where IG-PCR was not informative. Performed for the first time on mediastinal lymphomas, IgLC-RNAsc identified monotypic IgLC transcripts in 69% of primary mediastinal large B-cell lymphoma (PMBCL) and 67% of mediastinal gray zone lymphomas (MGZL). IGK/L double-negative cells were detected in 1 PMBCL, 2 MGZL, and all classical HL, while monotypic IgLC expression appeared to be a hallmark in nodular lymphocyte-predominant HL. IgLC-RNAsc demonstrates to be a powerful tool in B-cell lymphoma diagnosis, above all in challenging cases with limited tumor cell content, ensuring in situ investigations on mechanisms of Ig regulation across lymphoma entities. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Massive parallel sequencing unveils homologous recombination deficiency in follicular dendritic cell sarcoma

Author

Lorenzi, Luisa, primary, Haferlach, Torsten, additional, Mori, Luigi, additional, Simbeni, Matteo, additional, Walter, Wencke, additional, Balzarini, Piera, additional, Meggendorfer, Manja, additional, Döring, Claudia, additional, Lonardi, Silvia, additional, Bugatti, Mattia, additional, Agostinelli, Claudio, additional, Mehta, Jay, additional, Borges, Anita, additional, Agaimy, Abbas, additional, Simonitsch-Klupp, Ingrid, additional, Cabeçadas, José, additional, Campo, Elias, additional, Pileri, Stefano Aldo, additional, Facchetti, Fabio, additional, Leo Hansmann, Martin, additional, and Hartmann, Sylvia, additional

Published
2023
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13. Large B-cell lymphoma with IRF4 rearrangement: a multi-centric study with focus on potential misleading phenotypes

Author

Pizzi, Marco, primary, Bongiovanni, Lucia, additional, Lorenzi, Luisa, additional, Righi, Simona, additional, Scarmozzino, Federico, additional, Balzarini, Piera, additional, Santoro, Luisa, additional, Mussolin, Lara, additional, Carraro, Elisa, additional, Pillon, Marta, additional, Bonaldi, Laura, additional, Vianello, Fabrizio, additional, Agostinelli, Claudio, additional, Ponzoni, Maurilio, additional, Dei Tos, Angelo Paolo, additional, and Sabattini, Elena, additional

Published
2023
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14. Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness.

Author

Monti, Matilde, primary, Gatta, Luisa Benerini, additional, Bugatti, Mattia, additional, Pezzali, Irene, additional, Picinoli, Sara, additional, Manfredi, Marcello, additional, Lavazza, Antonio, additional, Vanella, Virginia Vita, additional, De Giorgis, Veronica, additional, Zanatta, Lucia, additional, Missale, Francesco, additional, Zanetti, Benedetta, additional, Bozzoni, Giovanni, additional, Cadei, Moris, additional, Vergani, Barbara, additional, Balzarini, Piera, additional, Battocchio, Simonetta, additional, Facco, Carla, additional, Turri-Zanoni, Mario, additional, Castelnuovo, Paolo, additional, Nicolai, Piero, additional, Fonsatti, Ester, additional, Leone, Biagio Eugenio, additional, Marengo, Emilio, additional, Ronca, Roberto, additional, Perego, Michela, additional, Lombardi, Davide, additional, and Vermi, William, additional

Published
2023
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18. Supplementary Figures from slan+ Monocytes and Macrophages Mediate CD20-Dependent B-cell Lymphoma Elimination via ADCC and ADCP

Author

Vermi, William, primary, Micheletti, Alessandra, primary, Finotti, Giulia, primary, Tecchio, Cristina, primary, Calzetti, Federica, primary, Costa, Sara, primary, Bugatti, Mattia, primary, Calza, Stefano, primary, Agostinelli, Claudio, primary, Pileri, Stefano, primary, Balzarini, Piera, primary, Tucci, Alessandra, primary, Rossi, Giuseppe, primary, Furlani, Lara, primary, Todeschini, Giuseppe, primary, Zamò, Alberto, primary, Facchetti, Fabio, primary, Lorenzi, Luisa, primary, Lonardi, Silvia, primary, and Cassatella, Marco A., primary

Published
2023
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19. Supplementary Figure S3 from Ligand-Dependent Activation of EGFR in Follicular Dendritic Cells Sarcoma is Sustained by Local Production of Cognate Ligands

Author

Vermi, William, primary, Giurisato, Emanuele, primary, Lonardi, Silvia, primary, Balzarini, Piera, primary, Rossi, Elisa, primary, Medicina, Daniela, primary, Bosisio, Daniela, primary, Sozzani, Silvano, primary, Pellegrini, Wilma, primary, Doglioni, Claudio, primary, Marchetti, Antonio, primary, Rossi, Giulio, primary, Pileri, Stefano, primary, and Facchetti, Fabio, primary

Published
2023
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20. Data from slan+ Monocytes and Macrophages Mediate CD20-Dependent B-cell Lymphoma Elimination via ADCC and ADCP

Author

Vermi, William, primary, Micheletti, Alessandra, primary, Finotti, Giulia, primary, Tecchio, Cristina, primary, Calzetti, Federica, primary, Costa, Sara, primary, Bugatti, Mattia, primary, Calza, Stefano, primary, Agostinelli, Claudio, primary, Pileri, Stefano, primary, Balzarini, Piera, primary, Tucci, Alessandra, primary, Rossi, Giuseppe, primary, Furlani, Lara, primary, Todeschini, Giuseppe, primary, Zamò, Alberto, primary, Facchetti, Fabio, primary, Lorenzi, Luisa, primary, Lonardi, Silvia, primary, and Cassatella, Marco A., primary

Published
2023
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21. Supplementary Material Table S6. from Ligand-Dependent Activation of EGFR in Follicular Dendritic Cells Sarcoma is Sustained by Local Production of Cognate Ligands

Author

Vermi, William, primary, Giurisato, Emanuele, primary, Lonardi, Silvia, primary, Balzarini, Piera, primary, Rossi, Elisa, primary, Medicina, Daniela, primary, Bosisio, Daniela, primary, Sozzani, Silvano, primary, Pellegrini, Wilma, primary, Doglioni, Claudio, primary, Marchetti, Antonio, primary, Rossi, Giulio, primary, Pileri, Stefano, primary, and Facchetti, Fabio, primary

Published
2023
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22. Supplementary Tables from slan+ Monocytes and Macrophages Mediate CD20-Dependent B-cell Lymphoma Elimination via ADCC and ADCP

Author

Vermi, William, primary, Micheletti, Alessandra, primary, Finotti, Giulia, primary, Tecchio, Cristina, primary, Calzetti, Federica, primary, Costa, Sara, primary, Bugatti, Mattia, primary, Calza, Stefano, primary, Agostinelli, Claudio, primary, Pileri, Stefano, primary, Balzarini, Piera, primary, Tucci, Alessandra, primary, Rossi, Giuseppe, primary, Furlani, Lara, primary, Todeschini, Giuseppe, primary, Zamò, Alberto, primary, Facchetti, Fabio, primary, Lorenzi, Luisa, primary, Lonardi, Silvia, primary, and Cassatella, Marco A., primary

Published
2023
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23. Supplementary Material from Ligand-Dependent Activation of EGFR in Follicular Dendritic Cells Sarcoma is Sustained by Local Production of Cognate Ligands

Author

Vermi, William, primary, Giurisato, Emanuele, primary, Lonardi, Silvia, primary, Balzarini, Piera, primary, Rossi, Elisa, primary, Medicina, Daniela, primary, Bosisio, Daniela, primary, Sozzani, Silvano, primary, Pellegrini, Wilma, primary, Doglioni, Claudio, primary, Marchetti, Antonio, primary, Rossi, Giulio, primary, Pileri, Stefano, primary, and Facchetti, Fabio, primary

Published
2023
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25. Transforming growth factor-beta1 induces microvascular abnormalities through a down-modulation of neural cell adhesion molecule in human hepatocellular carcinoma

Author

Balzarini, Piera, Benetti, Anna, Invernici, Gloria, Cristini, Silvia, Zicari, Sonia, Caruso, Arnaldo, Gatta, Luisa B, Berenzi, Angiola, Imberti, Luisa, Zanotti, Cinzia, Portolani, Nazario, Giulini, Stefano M, Ferrari, Maura, Ciusani, Emilio, Navone, Stefania E, Canazza, Alessandra, Parati, Eugenio A, and Alessandri, Giulio

Published
2012
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26. Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas

Author

L'Imperio, V, Morello, G, Vegliante, M, Cancila, V, Bertolazzi, G, Mazzara, S, Belmonte, B, Mangogna, A, Balzarini, P, Corral, L, Lopez, G, Di Napoli, A, Facchetti, F, Pagni, F, Tripodo, C, L'Imperio, Vincenzo, Morello, Gaia, Vegliante, Maria Carmela, Cancila, Valeria, Bertolazzi, Giorgio, Mazzara, Saveria, Belmonte, Beatrice, Mangogna, Alessandro, Balzarini, Piera, Corral, Lilia, Lopez, Gianluca, Di Napoli, Arianna, Facchetti, Fabio, Pagni, Fabio, Tripodo, Claudio, L'Imperio, V, Morello, G, Vegliante, M, Cancila, V, Bertolazzi, G, Mazzara, S, Belmonte, B, Mangogna, A, Balzarini, P, Corral, L, Lopez, G, Di Napoli, A, Facchetti, F, Pagni, F, Tripodo, C, L'Imperio, Vincenzo, Morello, Gaia, Vegliante, Maria Carmela, Cancila, Valeria, Bertolazzi, Giorgio, Mazzara, Saveria, Belmonte, Beatrice, Mangogna, Alessandro, Balzarini, Piera, Corral, Lilia, Lopez, Gianluca, Di Napoli, Arianna, Facchetti, Fabio, Pagni, Fabio, and Tripodo, Claudio

Abstract

The GC reaction results in the selection of B cells acquiring effector Ig secreting ability by progressing toward plasmablastic differentiation. This transition is associated with exclusion from the GC microenvironment. The aberrant expansion of plasmablastic elements within the GC fringes configures an atypical condition, the biological characteristics of which have not been defined yet. We investigated the in situ immunophenotypical and transcriptional characteristics of a nonclonal germinotropic expansion of plasmablastic elements (GEx) occurring in the tonsil of a young patient. Compared to neighboring GC and perifollicular regions, the GEx showed a distinctive signature featuring key regulators of plasmacytic differentiation, cytokine signaling, and cell metabolism. The GEx signature was tested in the setting of diffuse large B-cell lymphoma (DLBCL) as a prototypical model of lymphomagenesis encompassing transformation at different stages of GC and post-GC functional differentiation. The signature outlined DLBCL clusters with different immune microenvironment composition and enrichment in genetic subtypes. This report represents the first insight into the transcriptional features of a germinotropic plasmablastic burst, shedding light into the molecular hallmarks of B cells undergoing plasmablastic differentiation and aberrant expansion within the noncanonical setting of the GC microenvironment.

Published
2022

27. Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88 / CD79B mutants‐enriched diffuse large B‐cell lymphomas

Author

L'Imperio, Vincenzo, primary, Morello, Gaia, additional, Vegliante, Maria Carmela, additional, Cancila, Valeria, additional, Bertolazzi, Giorgio, additional, Mazzara, Saveria, additional, Belmonte, Beatrice, additional, Mangogna, Alessandro, additional, Balzarini, Piera, additional, Corral, Lilia, additional, Lopez, Gianluca, additional, Di Napoli, Arianna, additional, Facchetti, Fabio, additional, Pagni, Fabio, additional, and Tripodo, Claudio, additional

Published
2022
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31. In situ transcriptional profile of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched Diffuse Large B-cell Lymphomas

Author

L’Imperio, Vincenzo, primary, Morello, Gaia, additional, Vegliante, Maria Carmela, additional, Cancila, Valeria, additional, Bertolazzi, Giorgio, additional, Mazzara, Saveria, additional, Belmonte, Beatrice, additional, Balzarini, Piera, additional, Corral, Lilia, additional, Napoli, Arianna Di, additional, Facchetti, Fabio, additional, Pagni, Fabio, additional, and Tripodo, Claudio, additional

Published
2021
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35. Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants‐enriched diffuse large B‐cell lymphomas.

Author

L'Imperio, Vincenzo, Morello, Gaia, Vegliante, Maria Carmela, Cancila, Valeria, Bertolazzi, Giorgio, Mazzara, Saveria, Belmonte, Beatrice, Mangogna, Alessandro, Balzarini, Piera, Corral, Lilia, Lopez, Gianluca, Di Napoli, Arianna, Facchetti, Fabio, Pagni, Fabio, and Tripodo, Claudio

Subjects
DIFFUSE large B-cell lymphomas, GERMINAL centers, B cells, TRANSCRIPTOMES, CELL metabolism
Abstract

The GC reaction results in the selection of B cells acquiring effector Ig secreting ability by progressing toward plasmablastic differentiation. This transition is associated with exclusion from the GC microenvironment. The aberrant expansion of plasmablastic elements within the GC fringes configures an atypical condition, the biological characteristics of which have not been defined yet. We investigated the in situ immunophenotypical and transcriptional characteristics of a nonclonal germinotropic expansion of plasmablastic elements (GEx) occurring in the tonsil of a young patient. Compared to neighboring GC and perifollicular regions, the GEx showed a distinctive signature featuring key regulators of plasmacytic differentiation, cytokine signaling, and cell metabolism. The GEx signature was tested in the setting of diffuse large B‐cell lymphoma (DLBCL) as a prototypical model of lymphomagenesis encompassing transformation at different stages of GC and post‐GC functional differentiation. The signature outlined DLBCL clusters with different immune microenvironment composition and enrichment in genetic subtypes. This report represents the first insight into the transcriptional features of a germinotropic plasmablastic burst, shedding light into the molecular hallmarks of B cells undergoing plasmablastic differentiation and aberrant expansion within the noncanonical setting of the GC microenvironment. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Rituximab with Dose-Adjusted EPOCH (R-DA-EPOCH) with or without Autologous Stem Cell Transplantation (ASCT) As First Line Treatment in Patients with Aggressive B-Cell Lymphoma with MYC and BCL-2 and/or BCL-6 Gene Rearrangements or Increase Copy Number

Author

Tucci, Alessandra, primary, Re, Alessandro, additional, Pagani, Chiara, additional, Guidetti, Anna, additional, Dodero, Anna, additional, Marino, Fabrizio, additional, Casaroli, Ivana, additional, Soverini, Giulia, additional, Daffini, Rosa, additional, Balzarotti, Monica, additional, Campostrini, Giulia, additional, Lorenzi, Luisa, additional, Balzarini, Piera, additional, Facchetti, Fabio, additional, Carlo-Stella, Carmelo, additional, Corradini, Paolo, additional, and Rossi, Giuseppe, additional

Published
2020
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39. Single Cell Analysis of Circulating Endothelial Cells in Allogeneic Hematopoietic Stem Cell Transplant; To Whom Do They Belong: Host or Donor?

Author

Almici, Camillo, primary, Fontana, Francesca, additional, Piovani, Giovanna, additional, Balzarini, Piera, additional, Neva, Arabella, additional, Bruno, Benedetto, additional, Skert, Cristina, additional, Rotta, GianLuca, additional, Fisogni, Simona, additional, Verardi, Rosanna, additional, Bianchetti, Andrea, additional, Braga, Simona, additional, Malagola, Michele, additional, Manaresi, Nicolò, additional, Facchetti, Fabio, additional, Marini, Mirella, additional, and Russo, Domenico, additional

Published
2019
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40. An increase in MYC copy number has a progressive negative prognostic impact in patients with diffuse large B-cell and high-grade lymphoma, who may benefit from intensified treatment regimens

Author

Schieppati, Francesca, primary, Balzarini, Piera, additional, Fisogni, Simona, additional, Re, Alessandro, additional, Pagani, Chiara, additional, Bianchetti, Nicola, additional, Micheli, Lorenzo, additional, Passi, Angela, additional, Ferrari, Samantha, additional, Maifredi, Adriana, additional, Bottelli, Chiara, additional, Leopaldo, Rossella, additional, Pellegrini, Vilma, additional, Facchetti, Fabio, additional, Rossi, Giuseppe, additional, and Tucci, Alessandra, additional

Published
2019
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44. Very Poor Outcome of Patients with Relapsed/Refractory Aggressive B Cell Lymphoma after Autologous Stem Cell Transplantation (ASCT) or High Dose of Methotrexate and Cytarabine (HD-MTX/ARA-C) Regimens in the Clinical Care Setting

Author

Bianchetti, Nicola, primary, Tucci, Alessandra, additional, Re, Alessandro, additional, Pagani, Chiara, additional, Cattaneo, Chiara, additional, Miscio, Maria, additional, Facchetti, Fabio, additional, Fisogni, Simona, additional, Balzarini, Piera, additional, Albano, Domenico, additional, Bosio, Giovanni, additional, Bertagna, Francesco, additional, and Rossi, Giuseppe, additional

Published
2018
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45. Cell-of-Origin Identification and Prognostic Correlation in HIV-Associated Diffuse Large B-Cell Lymphomas: Results of an Italian Multicentric Study

Author

Rusconi, Chiara, primary, Re, Alessandro, additional, Bandiera, Laura, additional, Crucitti, Lara, additional, Spina, Michele, additional, Gini, Guido, additional, Paulli, Marco, additional, Lucioni, Marco, additional, Facchetti, Fabio, additional, Goteri, Gaia, additional, Canzonieri, Vincenzo, additional, Lorenzi, Luisa, additional, Balzarini, Piera, additional, Fisogni, Simona, additional, Malfitano, Antonello, additional, Bonfichi, Maurizio, additional, Moioli, Maria Cristina, additional, Nichelatti, Michele, additional, Melle, Federica, additional, Motta, Giovanna, additional, Pileri, Stefano A., additional, and Cairoli, Roberto, additional

Published
2018
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46. slan+ Monocytes and Macrophages Mediate CD20-Dependent B-cell Lymphoma Elimination via ADCC and ADCP

Author

Vermi, William, primary, Micheletti, Alessandra, additional, Finotti, Giulia, additional, Tecchio, Cristina, additional, Calzetti, Federica, additional, Costa, Sara, additional, Bugatti, Mattia, additional, Calza, Stefano, additional, Agostinelli, Claudio, additional, Pileri, Stefano, additional, Balzarini, Piera, additional, Tucci, Alessandra, additional, Rossi, Giuseppe, additional, Furlani, Lara, additional, Todeschini, Giuseppe, additional, Zamò, Alberto, additional, Facchetti, Fabio, additional, Lorenzi, Luisa, additional, Lonardi, Silvia, additional, and Cassatella, Marco A., additional

Published
2018
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48. Tumor-forming plasmacytoid dendritic cells associated with myeloid neoplasms. Report of a peculiar case with histopathologic features masquerading as lupus erythematosus

Author

Dargent, Jean Louis, Henne, Stéphanie, Pranger, Delphine, Balzarini, Piera, Sartenaer, Daniel, Bulliard, Geneviève, Rack, Katrina, and Facchetti, Fabio

Subjects
Male, Chronic myelomonocytic leukemia, Lupus erythematosus, Plasmacytoid dendritic cells, 2708, 2734, Histology, Skin Neoplasms, Plasma Cells, Dendritic Cells, Dermis, Middle Aged, Leukemia, Myeloid, Lupus Erythematosus, Cutaneous, Humans
Abstract

Plasmacytoid dendritic cells (PDC) belong to a subtype of dendritic cells that are normally absent in healthy skin. In some inflammatory diseases of the skin, especially lupus erythematosus (LE), these cells are occasionally recruited in great amounts, which can be used as a helpful clue for diagnosis. Rarely, PDC may also accumulate in the skin of patients with myeloid leukemia, a yet poorly known condition currently called 'tumor-forming PDC associated with myeloid neoplasms'. In this study, we describe a patient with unsuspected chronic myelomonocytic leukemia who developed cutaneous lesions characterized by a dermal infiltrate rich in PDC. Similarly to LE, such neoplastic PDC were accompanied by interface dermatitis-like changes, but displayed an aberrant phenotype and shared the same chromosomal abnormality with the leukemic cells identified in the bone marrow, thus revealing the neoplastic nature of the process. This observation illustrates that tumor-forming PDC associated with myeloid neoplasms may microscopically mimic LE in some patients. Accordingly, a hematologic workup is recommended in any skin lesion featuring excessive numbers of PDC, even if morphological alterations suggestive of interface dermatitis are found.

Published
2015

49. Unfavorable Prognostic Impact of MYC Increased Copy Number (ICN) in Patients with Diffuse Large B-Cell and High-Grade Lymphoma Treated with Immuno-Chemotherapy (ICT)

Author

Schieppati, Francesca, primary, Fisogni, Simona, additional, Balzarini, Piera, additional, Re, Alessandro, additional, Lorenzi, Luisa, additional, Dalceggio, Daniela, additional, Passi, Angela, additional, Cattaneo, Chiara, additional, Facchetti, Fabio, additional, Rossi, Giuseppe, additional, and Tucci, Alessandra, additional

Published
2016
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