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1,467 results on '"Banchereau, Jacques"'

1. Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults

Author

Ravichandran, Sathyabaarathi, Erra-Diaz, Fernando, Karakaslar, Onur E., Marches, Radu, Kenyon-Pesce, Lisa, Rossi, Robert, Chaussabel, Damien, Nehar-Belaid, Djamel, LaFon, David C., Pascual, Virginia, Palucka, Karolina, Paust, Silke, Nahm, Moon H., Kuchel, George A., Banchereau, Jacques, and Ucar, Duygu

Published
2024
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2. SystemMatch: optimizing preclinical drug models to human clinical outcomes via generative latent-space matching

Author

Gigante, Scott, Raghavan, Varsha G., Robinson, Amanda M., Barton, Robert A., Rahman, Adeeb H., Wulsin, Drausin F., Banchereau, Jacques, Solomon, Noam, Voloch, Luis F., and Theis, Fabian J.

Subjects
Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods
Abstract

Translating the relevance of preclinical models ($\textit{in vitro}$, animal models, or organoids) to their relevance in humans presents an important challenge during drug development. The rising abundance of single-cell genomic data from human tumors and tissue offers a new opportunity to optimize model systems by their similarity to targeted human cell types in disease. In this work, we introduce SystemMatch to assess the fit of preclinical model systems to an $\textit{in sapiens}$ target population and to recommend experimental changes to further optimize these systems. We demonstrate this through an application to developing $\textit{in vitro}$ systems to model human tumor-derived suppressive macrophages. We show with held-out $\textit{in vivo}$ controls that our pipeline successfully ranks macrophage subpopulations by their biological similarity to the target population, and apply this analysis to rank a series of 18 $\textit{in vitro}$ macrophage systems perturbed with a variety of cytokine stimulations. We extend this analysis to predict the behavior of 66 $\textit{in silico}$ model systems generated using a perturbational autoencoder and apply a $k$-medoids approach to recommend a subset of these model systems for further experimental development in order to fully explore the space of possible perturbations. Through this use case, we demonstrate a novel approach to model system development to generate a system more similar to human biology., Comment: Published at the MLDD workshop, ICLR 2022

Published
2022

7. MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

Author

Verma, Vivek, Jafarzadeh, Nazli, Boi, Shannon, Kundu, Subhadip, Jiang, Zhinuo, Fan, Yiping, Lopez, Jose, Nandre, Rahul, Zeng, Peng, Alolaqi, Fatmah, Ahmad, Shamim, Gaur, Pankaj, Barry, Simon T., Valge-Archer, Viia E., Smith, Paul D., Banchereau, Jacques, Mkrtichyan, Mikayel, Youngblood, Benjamin, Rodriguez, Paulo C., Gupta, Seema, and Khleif, Samir N.

Published
2021
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9. Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

Author

Altman, Matthew C., Rinchai, Darawan, Baldwin, Nicole, Toufiq, Mohammed, Whalen, Elizabeth, Garand, Mathieu, Syed Ahamed Kabeer, Basirudeen, Alfaki, Mohamed, Presnell, Scott R., Khaenam, Prasong, Ayllón-Benítez, Aaron, Mougin, Fleur, Thébault, Patricia, Chiche, Laurent, Jourde-Chiche, Noemie, Phillips, J. Theodore, Klintmalm, Goran, O’Garra, Anne, Berry, Matthew, Bloom, Chloe, Wilkinson, Robert J., Graham, Christine M., Lipman, Marc, Lertmemongkolchai, Ganjana, Bedognetti, Davide, Thiebaut, Rodolphe, Kheradmand, Farrah, Mejias, Asuncion, Ramilo, Octavio, Palucka, Karolina, Pascual, Virginia, Banchereau, Jacques, and Chaussabel, Damien

Published
2021
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11. Mapping systemic lupus erythematosus heterogeneity at the single-cell level

Author

Nehar-Belaid, Djamel, Hong, Seunghee, Marches, Radu, Chen, Guo, Bolisetty, Mohan, Baisch, Jeanine, Walters, Lynnette, Punaro, Marilynn, Rossi, Robert J., Chung, Cheng-Han, Huynh, Richie P., Singh, Prashant, Flynn, William F., Tabanor-Gayle, Joy-Ann, Kuchipudi, Navya, Mejias, Asuncion, Collet, Magalie A., Lucido, Anna Lisa, Palucka, Karolina, Robson, Paul, Lakshminarayanan, Santhanam, Ramilo, Octavio, Wright, Tracey, Pascual, Virginia, and Banchereau, Jacques F.

Published
2020
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12. Sestrins induce natural killer function in senescent-like CD8+ T cells

Author

Pereira, Branca I., De Maeyer, Roel P. H., Covre, Luciana P., Nehar-Belaid, Djamel, Lanna, Alessio, Ward, Sophie, Marches, Radu, Chambers, Emma S., Gomes, Daniel C. O., Riddell, Natalie E., Maini, Mala K., Teixeira, Vitor H., Janes, Samuel M., Gilroy, Derek W., Larbi, Anis, Mabbott, Neil A., Ucar, Duygu, Kuchel, George A., Henson, Sian M., Strid, Jessica, Lee, Jun H., Banchereau, Jacques, and Akbar, Arne N.

Published
2020
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13. An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes

Author

Caielli, Simone, primary, Balasubramanian, Preetha, additional, Rodriguez-Alcazar, Juan, additional, Balaji, Uthra, additional, Wan, Zurong, additional, Baisch, Jeanine, additional, Smitherman, Cynthia, additional, Walters, Lynnette, additional, Sparagana, Paola, additional, Nehar-Belaid, Djamel, additional, Marches, Radu, additional, Nassi, Lorien, additional, Stewart, Katie, additional, Fuller, Julie, additional, Banchereau, Jacques F., additional, Gu, Jinghua, additional, Wright, Tracey, additional, and Pascual, Virginia, additional

Published
2023
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15. Alterations in the Rho pathway contribute to Epstein-Barr virus–induced lymphomagenesis in immunosuppressed environments

Author

Cho, Sung-Yup, Sung, Chang Ohk, Chae, Jeesoo, Lee, Jieun, Na, Deukchae, Kang, Wonyoung, Kang, Jinjoo, Min, Seoyeon, Lee, Ahra, Kwak, Eunhye, Kim, Jooyoung, Choi, Boram, Kim, Hyunsoo, Chuang, Jeffrey H., Pak, Hyo-Kyung, Park, Chan-Sik, Park, Sanghui, Ko, Young Hyeh, Lee, Dakeun, Roh, Jin, Cho, Min-Sun, Park, Seongyeol, Ju, Young Seok, Suh, Yun-Suhk, Kong, Seong-Ho, Lee, Hyuk-Joon, Keck, James, Banchereau, Jacques, Liu, Edison T., Kim, Woo-Ho, Park, Hansoo, Yang, Han-Kwang, Kim, Jong-Il, and Lee, Charles

Published
2018
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16. A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate

Author

Caielli, Simone, Veiga, Diogo Troggian, Balasubramanian, Preetha, Athale, Shruti, Domic, Bojana, Murat, Elise, Banchereau, Romain, Xu, Zhaohui, Chandra, Manjari, Chung, Cheng-Han, Walters, Lynnette, Baisch, Jeanine, Wright, Tracey, Punaro, Marilynn, Nassi, Lorien, Stewart, Katie, Fuller, Julie, Ucar, Duygu, Ueno, Hideki, Zhou, Joseph, Banchereau, Jacques, and Pascual, Virginia

Published
2019
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18. Pre-vaccination CD56 dimCD16 +NK cell abundance and T h1/T h17 ratio predict responsiveness to conjugated pneumococcal vaccine in older adults

Author

Ravichandran, Sathya Baarathi Shanthi, primary, Diaz, Fernando E, additional, Karakaslar, Onur E, additional, Marches, Radu, additional, Rossi, Robert, additional, Nahm, Moon H, additional, Chaussabel, Damien, additional, Kuchel, George, additional, Banchereau, Jacques, additional, and Ucar, Duygu, additional

Published
2023
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19. Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults

Author

Ravichandran, Sathyabaarathi, primary, Erra-Diaz, Fernando, additional, Karakaslar, Emin Onur, additional, Marches, Radu, additional, Kenyon-Pesce, Lisa, additional, Rossi, Robert, additional, Chaussabel, Damien, additional, Pascual, Virginia, additional, Palucka, Karolina, additional, Paust, Silke, additional, Nahm, Moon H., additional, Kuchel, George A., additional, Banchereau, Jacques, additional, and Ucar, Duygu, additional

Published
2023
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20. Supplementary Table 2 from Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

Author

Wu, Te-Chia, primary, Xu, Kangling, primary, Banchereau, Romain, primary, Marches, Florentina, primary, Yu, Chun I., primary, Martinek, Jan, primary, Anguiano, Esperanza, primary, Pedroza-Gonzalez, Alexander, primary, Snipes, G. Jackson, primary, O'Shaughnessy, Joyce, primary, Nishimura, Stephen, primary, Liu, Yong-Jun, primary, Pascual, Virginia, primary, Banchereau, Jacques, primary, Oh, Sangkon, primary, and Palucka, Karolina, primary

Published
2023
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21. Data from Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

Author

Wu, Te-Chia, primary, Xu, Kangling, primary, Banchereau, Romain, primary, Marches, Florentina, primary, Yu, Chun I., primary, Martinek, Jan, primary, Anguiano, Esperanza, primary, Pedroza-Gonzalez, Alexander, primary, Snipes, G. Jackson, primary, O'Shaughnessy, Joyce, primary, Nishimura, Stephen, primary, Liu, Yong-Jun, primary, Pascual, Virginia, primary, Banchereau, Jacques, primary, Oh, Sangkon, primary, and Palucka, Karolina, primary

Published
2023
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22. Supplementary Table 1 from Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

Author

Wu, Te-Chia, primary, Xu, Kangling, primary, Banchereau, Romain, primary, Marches, Florentina, primary, Yu, Chun I., primary, Martinek, Jan, primary, Anguiano, Esperanza, primary, Pedroza-Gonzalez, Alexander, primary, Snipes, G. Jackson, primary, O'Shaughnessy, Joyce, primary, Nishimura, Stephen, primary, Liu, Yong-Jun, primary, Pascual, Virginia, primary, Banchereau, Jacques, primary, Oh, Sangkon, primary, and Palucka, Karolina, primary

Published
2023
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23. Supplementary Table 3 from Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

Author

Wu, Te-Chia, primary, Xu, Kangling, primary, Banchereau, Romain, primary, Marches, Florentina, primary, Yu, Chun I., primary, Martinek, Jan, primary, Anguiano, Esperanza, primary, Pedroza-Gonzalez, Alexander, primary, Snipes, G. Jackson, primary, O'Shaughnessy, Joyce, primary, Nishimura, Stephen, primary, Liu, Yong-Jun, primary, Pascual, Virginia, primary, Banchereau, Jacques, primary, Oh, Sangkon, primary, and Palucka, Karolina, primary

Published
2023
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24. Data from IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer

Author

Wu, Te-Chia, primary, Xu, Kangling, primary, Martinek, Jan, primary, Young, Robyn R., primary, Banchereau, Romain, primary, George, Joshy, primary, Turner, Jacob, primary, Kim, Kyung In, primary, Zurawski, Sandra, primary, Wang, Xuan, primary, Blankenship, Derek, primary, Brookes, Hannah M., primary, Marches, Florentina, primary, Obermoser, Gerlinde, primary, Lavecchio, Elizabeth, primary, Levin, Maren K., primary, Bae, Sookyoung, primary, Chung, Cheng-Han, primary, Smith, Jennifer L., primary, Cepika, Alma-Martina, primary, Oxley, Kyp L., primary, Snipes, George J., primary, Banchereau, Jacques, primary, Pascual, Virginia, primary, O'Shaughnessy, Joyce, primary, and Palucka, A. Karolina, primary

Published
2023
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25. Table S4 from IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer

Author

Wu, Te-Chia, primary, Xu, Kangling, primary, Martinek, Jan, primary, Young, Robyn R., primary, Banchereau, Romain, primary, George, Joshy, primary, Turner, Jacob, primary, Kim, Kyung In, primary, Zurawski, Sandra, primary, Wang, Xuan, primary, Blankenship, Derek, primary, Brookes, Hannah M., primary, Marches, Florentina, primary, Obermoser, Gerlinde, primary, Lavecchio, Elizabeth, primary, Levin, Maren K., primary, Bae, Sookyoung, primary, Chung, Cheng-Han, primary, Smith, Jennifer L., primary, Cepika, Alma-Martina, primary, Oxley, Kyp L., primary, Snipes, George J., primary, Banchereau, Jacques, primary, Pascual, Virginia, primary, O'Shaughnessy, Joyce, primary, and Palucka, A. Karolina, primary

Published
2023
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35. SEXUAL-DIMORPHISM IN HUMAN IMMUNE SYSTEM AGING

Author

Ucar, Duygu, primary, Kuchel, George, additional, Banchereau, Jacques, additional, Ravichandran, Sathyabaarathi, additional, Karakaslar, Onur, additional, Diaz, Fernando Erra, additional, Marquez, Eladio, additional, and Marches, Radu, additional

Published
2022
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45. Immunotherapy Via Dendritic Cells

Author

Palucka, A. Karolina, Laupeze, Beatrice, Aspord, Caroline, Saito, Hiroaki, Jego, Gaetan, Fay, Joseph, Paczesny, Sophie, Pascual, Virginia, Banchereau, Jacques, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Gupta, Sudhir, editor, Paul, William E., editor, and Steinman, Ralph, editor

Published
2005
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