Search

Your search keyword '"Bao, Hexin"' showing total 12 results
Start Over Author "Bao, Hexin"
12 results on '"Bao, Hexin"'

3. Mono- and Co-Doped Mn-Doped CsPbCl 3 Perovskites with Enhanced Doping Efficiency and Photoluminescent Performance.

Author

Jiang, Hao, Zhao, Yiting, Liu, Fangchao, Yan, Yongqi, Ma, Yinuo, Bao, Hexin, Wu, Zhongchen, Cong, Wei-Yan, and Lu, Ying-Bo

Subjects
DOPING agents (Chemistry), JAHN-Teller effect, PEROVSKITE, BAND gaps, BOND strengths, OCTAHEDRA
Abstract

To investigate the effect of Mn and other metal dopants on the photoelectronic performance of CsPbCl3 perovskites, we conducted a series of theoretical analyses. Our findings showed that after Mn mono-doping, the CsPbCl3 lattice contracted and the bonding strength increased, resulting in a more compact structure of the metal octahedral cage. The relaxation of the metal octahedral cage, along with the Jahn–Teller effect, results in a decrease in lattice strain between the octahedra and a reduction in the energy of the entire lattice due to the deformation of the metal octahedron. These three factors work together to reduce intrinsic defects and enhance the stability and electronic properties of CsPbCl3 perovskites. The solubility of the Mn dopant is significantly increased when co-doped with Ni, Fe, and Co dopants, as it compensates for the lattice strain induced by Mn. Doping CsPbCl3 perovskites reduces the band gap due to the decreased contributions of 3d orbitals from the dopants. Our analyses have revealed that strengthening the CsPbCl3 lattice and reducing intrinsic defects can result in improved stability and PL properties. Moreover, increasing Mn solubility and decreasing the bandgap can enhance the PLQY of orange luminescence in CsPbCl3 perovskites. These findings offer valuable insights for the development of effective strategies to enhance the photoelectronic properties of these materials. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

8. Constructing new acid-activated anticancer peptide by attaching a desirable anionic binding partner peptide

Author

Zhang, Yun, Chang, Linlin, Bao, Hexin, Wu, Xiaoyan, Liu, Hui, Gou, Sanhu, Zhang, Jingying, and Ni, Jingman

Subjects
Phagocytosis, Pharmaceutical Science, Glutamic Acid, Histidine, Disulfides, Peptides
Abstract

Improving the cell selectivity of anticancer peptides (ACPs) is a major hurdle in their clinical utilisation. In this study, a new acid-activated ACP was designed by conjugating a cationic ACP LK to its anionic binding partner peptide (LEH) via a disulphide linker to trigger antitumor activity at acidic pH while masking its killing activity at normal pH. Three anionic binding peptides containing different numbers of glutamic acid (Glu) and histidine were engineered to obtain an efficient acid-activated ACP. The conjugates LK-LEH2 and LK-LEH3 exhibited 6.1- and 8.0-fold higher killing activity at pH 6.0 relative to at pH 7.4, respectively, suggesting their excellent pH-dependent antitumor activity; and their cytotoxicity was 10-fold lower than that of LK. However, LK-LEH4 had no pH-responsive killing effect. Interestingly, increasing the number of Glu from 2 to 4 increased the pH-response of the physical mixture of LK and LEH; conversely, they weakly decreased the cytotoxicity of LK, suggesting that the conjugate connection is required to achieve excellent pH dependence while maintaining minimum toxicity. LK-LEH2 and LK-LEH3 were more enzymatically stable than LK, indicating their potential for in vivo application. Our work provided a basis for designing promising ACPs with good selectivity and low toxicity.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results