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To satisfy the requirements on loading ability and manoeuvrability of the wall-climbing robot, a novel magnetic adsorption device with variable magnetic force was proposed. First, its configuration was introduced and three-dimensional magnetic field models were established, then the magnetic field of novel magnetic adsorption unit based on finite element method was analyzed, and its magnetic flux density distribution and magnetic adsorption force were obtained. The APDL parametric technology of ANSYS was used to optimize the dimensions of magnetic unit, and optimization principle was obtained by analysis. By simulation and comparison of performance parameters of traditional H-shaped magnetic adsorption device, it is shown that the novel one has the characteristics of high utilization of permanent magnet, large ratio of the maximum and minimum adsorption force, light weight and strong loading ability. The result is proved by experiment and provides the basis for the design of wall-climbing robot magnetic adsorption device. [ABSTRACT FROM AUTHOR]

Magnaporthe oryzae is a filamentous fungus that causes rice blast. Rice blast seriously threatens the safety of food production. The normal synthesis and metabolism of fatty acids are extremely important for eukaryotes, and acyl-CoA is involved in fatty acid metabolism. Acyl-CoA binding (ACB) proteins specifically bind both medium-chain and long-chain acyl-CoA esters. However, the role of the Acb protein in plant-pathogenic fungi has not yet been investigated. Here, we identified MoAcb1, a homolog of the Acb protein in Saccharomyces cerevisiae . Disruption of MoACB1 causes delayed hyphal growth, significant reduction in conidial production and delayed appressorium development, glycogen availability, and reduced pathogenicity. Using immunoblotting and chemical drug sensitivity analysis, MoAcb1 was found to be involved in endoplasmic reticulum autophagy (ER-phagy). In conclusion, our results suggested that MoAcb1 is involved in conidia germination, appressorium development, pathogenicity and autophagy processes in M. oryzae ., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Cao, Zhu, Bao, Zhu, Liu, Lin and Li.)

Curcumin, traditionally used as food and medicinal purposes, has recently been reported to have protective efficacy against hypoxia. Hypoxia is one of the important reactive factors in tumor metastasis, which is a key problem in clinical thyroid cancer therapy. In present study, we investigate the anti-metastatic effect of curcumin on the K1 papillary thyroid cancer cells as well as its potential mechanisms. The results show that curcumin effectively inhibits hypoxia-induced reactive oxygen species (ROS) upregulation and significantly decreases the mRNA and protein expression levels of hypoxia-inducible factor-1α (HIF-1α) in K1 cells. Curcumin also decreases the DNA binding ability of HIF-1α to hypoxia response element (HRE). Furthermore, curcumin enhances E-cadherin expression, inhibits metalloproteinase-9 (MMP-9) enzyme activity, and weakens K1 cells migration under hypoxic conditions. In summary, these results indicate that curcumin possesses a potent anti-metastatic effect and might be an effective tumoristatic agent for the treatment of aggressive papillary thyroid cancers., (© 2014 by the Society for Experimental Biology and Medicine.)