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Your search keyword '"Bao, Xue-Feng"' showing total 12 results
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12 results on '"Bao, Xue-Feng"'

5. Cycloartane-type triterpenoids from the root of Astragalus membranaceus var. mongholicus

Author

Luo-Min Xiao, Cao, Pei-Hong, Luo, Zhi-Hui, Bao, Xue-Feng, Zheng-Qun Zhou, Li, Shuang, Sen-Sen Zhao, Zheng, Jun-Xia, Gao, Hao, and Zhi, Hui

Abstract

Three new (1–3) and 11 known (4–14) cycloartane-type triterpenoids were isolated from the root of Astragalus membranaceus var. mongholicus. Their structures were determined by spectroscopic analyses and chemical methods. Cycloartane-type triterpenoids are a class of major bioactive constituents in the root of A. membranaceus var. mongholicus, and the discovery of compounds 1–3 added new members of this kind of natural product.

Published
2020
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6. Astramalabaricosides A–T, Highly Oxygenated Malabaricane Triterpenoids with Migratory Inhibitory Activity from Astragalus membranaceusvar. mongholicus

Author

Luo, Zhi-Hui, Zeng, Jin, Yu, Hai-Yang, Huang, Hui-Yun, Bao, Xue-Feng, Qin, Sheng-Ying, Chen, Guo-Dong, Zhou, Zheng-Qun, Zhi, Hui, Yao, Xin-Sheng, and Gao, Hao

Abstract

Twenty new malabaricane triterpenoids, astramalabaricosides A–T (1–20), were isolated from the roots of Astragalus membranaceusvar. mongholicus(Astragali Radix). Their structures were determined by spectroscopic analysis, and the use of the circular dichroism exciton chirality method, quantum chemical calculations, and chemical methods. Malabaricane triterpenoids, an unusual group with the 6-6-5-tricyclic core, are distributed in plants (e.g., Simaroubaceae, Polypodiaceae, and Fabaceae), a marine sponge, and fungi, and their number obtained to date is limited. Compounds 1–20were characterized as glycosides with a highly oxygenated side chain, and 13–20were the first cyclic carbonate derivatives among the malabaricane triterpenoids. The stereocluster formed from the continuous hydroxylated chiral carbons in each highly oxygenated side chain and the 6-6-5-tricyclic core system were entirely segregated, and the independent identification of their stereoconfigurations required considerable effort. The migratory inhibitory and antiproliferative activities of 1–20were evaluated by wound-healing and cell-viability assays, respectively. Most compounds showed significant migratory inhibitory activity, and a preliminary structure–activity relationship was developed. Malabaricane triterpenoids are being reported in the genus Astragalusfor the first time.

Published
2022
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9. Cladosporine A, a new indole diterpenoid alkaloid with antimicrobial activities from Cladosporium sp.

Author

Han, Xue, Bao, Xue-Feng, Wang, Chuan-Xi, Xie, Jun, Song, Xiao-Jun, Dai, Ping, Chen, Guo-Dong, Hu, Dan, Yao, Xin-Sheng, and Gao, Hao

Subjects
INDOLE alkaloids, CLADOSPORIUM, ANDROGRAPHIS paniculata, ASPERGILLUS niger, CIRCULAR dichroism, CANDIDA albicans
Abstract

Cladosporine A (1), a new indole diterpenoid alkaloid, was isolated from the extract of a fungal strain Cladosporium sp. JNU17DTH12-9-01. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configurations were determined by electronic circular dichroism (ECD) experiments. This is the first report of the presence of indole diterpenoid alkaloid in the genus Cladosporium. The antimicrobial activities against Staphylococcus aureus 209P, Escherichia coli ATCC0111, Aspergillus niger R330, and Candida albicans FIM709 were evaluated. Compound 1 showed MICs of 4 μg/mL and 16 μg/mL against S. aureus 209P and C. albicans FIM709, respectively. [ABSTRACT FROM AUTHOR]

Published
2021
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10. A microbial model of mammalian metabolism: biotransformation of 4,5-dimethoxyl-canthin-6-one using Cunninghamella blakesleeana CGMCC 3.970

Author

Fan, Hong-Xia, Zheng-Qun Zhou, Peng, Jun, Wu, Bao-Jian, He-Ru Chen, Bao, Xue-Feng, Mu, Zhen-Qiang, Jiao, Wei-Hua, Yao, Xin-Sheng, and Gao, Hao

Abstract

1. A filamentous fungus, Cunninghamella blakesleeana CGMCC 3.970, was applied as a microbial system to mimic mammalian metabolism of 4,5-dimethoxyl-canthin-6-one (1). Compound 1 belongs to canthin-6-one type alkaloids, which is a major bioactive constituent of a traditional Chinese medicine (the stems of Picrasma quassioides). 2. After 72 h of incubation in potato dextrose broth, 1 was metabolized to seven metabolites as follows: 4-methoxyl-5-hydroxyl-canthin-6-one (M1), 4-hydroxyl-5-methoxyl-canthin-6-one (M2), canthin-6-one (M3), canthin-6-one N-oxide (M4), 10-hydroxyl-4,5-dimethoxyl-canthin-6-one (M5), 1-methoxycarbonl-β-carboline (M6), and 4-methoxyl-5-O-β-D-glucopyranosyl-canthin-6-one (M7). 3. The structures of metabolites were determined using spectroscopic analyses, chemical methods, and comparison of NMR data with those of known compounds. Among them, M7 was a new compound. 4. The metabolic pathways of 1 were proposed, and the metabolic processes involved phase I (O-demethylation, dehydroxylation, demethoxylation, N-oxidation, hydroxylation, and oxidative ring cleavage) and phase II (glycosylation) reactions. 5. This was the first research on microbial transformation of canthin-6-one alkaloid, which could be a useful microbial model for producing the mammalian phase I and phase II metabolites of canthin-6-one alkaloids. 6. 1, M1−M5, and M7 are canthin-6-one alkaloids, whereas M6 belongs to β-carboline type alkaloids. The strain of Cunninghamella blakesleeana can supply an approach to transform canthin-6-one type alkaloids into β-carboline type alkaloids.

Published
2016
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12. A microbial model of mammalian metabolism: biotransformation of 4,5-dimethoxyl-canthin-6-one using Cunninghamella blakesleeana CGMCC 3.970.

Author

Fan, Hong-Xia, Zhou, Zheng-Qun, Peng, Jun, Wu, Bao-Jian, Chen, He-Ru, Bao, Xue-Feng, Mu, Zhen-Qiang, Jiao, Wei-Hua, Yao, Xin-Sheng, and Gao, Hao

Subjects
BIOTRANSFORMATION (Metabolism), ALKALOIDS, METABOLITES, CARBOLINES, HYDROXYLATION, MAMMALS
Abstract

1. A filamentous fungus,Cunninghamella blakesleeanaCGMCC 3.970, was applied as a microbial system to mimic mammalian metabolism of 4,5-dimethoxyl-canthin-6-one (1). Compound1belongs to canthin-6-one type alkaloids, which is a major bioactive constituent of a traditional Chinese medicine (the stems ofPicrasma quassioides). 2. After 72 h of incubation in potato dextrose broth,1was metabolized to seven metabolites as follows: 4-methoxyl-5-hydroxyl-canthin-6-one (M1), 4-hydroxyl-5-methoxyl-canthin-6-one (M2), canthin-6-one (M3), canthin-6-oneN-oxide (M4), 10-hydroxyl-4,5-dimethoxyl-canthin-6-one (M5), 1-methoxycarbonl-β-carboline (M6), and 4-methoxyl-5-O-β-D-glucopyranosyl-canthin-6-one (M7). 3. The structures of metabolites were determined using spectroscopic analyses, chemical methods, and comparison of NMR data with those of known compounds. Among them,M7was a new compound. 4. The metabolic pathways of1were proposed, and the metabolic processes involved phase I (O-demethylation, dehydroxylation, demethoxylation,N-oxidation, hydroxylation, and oxidative ring cleavage) and phase II (glycosylation) reactions. 5. This was the first research on microbial transformation of canthin-6-one alkaloid, which could be a useful microbial model for producing the mammalian phase I and phase II metabolites of canthin-6-one alkaloids. 6. 1,M1−M5, andM7are canthin-6-one alkaloids, whereasM6belongs toβ-carboline type alkaloids. The strain ofCunninghamella blakesleeanacan supply an approach to transform canthin-6-one type alkaloids intoβ-carboline type alkaloids. [ABSTRACT FROM PUBLISHER]

Published
2017
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