7 results on '"Baoting Chao"'
Search Results
2. Middle lobe preservation and fixation after right upper and lower lobectomy for synchronous lung cancer
- Author
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Hua Jiang, Bingqing Yue, Jiankai Wang, Baoting Chao, and Weixia Ma
- Subjects
Lung cancer ,middle lobe preservation ,pulmonary bilobectomy ,pulmonary function. ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract The incidence of multiple lung cancer has been steadily increasing worldwide. Although cases of patients with lung cancers in the right upper and lower lobe have also become more frequently reported in clinical work, simultaneous right upper and lower lobectomy reports with the middle lobe preservation are still quite rare. A total of three patients with lung cancers in the right upper and lower lobe were included in the study. The patients underwent simultaneous right upper and lower lobectomy, whereas the remaining middle lobe was sutured and fixed to the intercostal muscle of the incision to prevent postoperative lobe torsion. There was no procedure to reduce residual space,such as phrenic nerve crush or thoracoplasty. All patients were discharged from the hospital 7 days after the operation. The chest tube was removed 5 days after the operation in two patients. One patient was discharged with the tube because of slight pulmonary leakage, and the tube was removed 2 weeks after the operation. Six months after the operation, the chest computer tomography showed that the middle lobe expanded well and no obvious cavity or pleural effusion was found. The suture of the remaining middle lobe and intercostal muscle of the incision is a simple and effective method that can be used to successfully avoid middle lobe torsion. This strategy is safe and can be used as the first choice for eligible patients.
- Published
- 2021
- Full Text
- View/download PDF
3. Abdominal aortic intimal flap motion characterization in acute aortic dissection: assessed with retrospective ECG-gated thoracoabdominal aorta dual-source CT angiography.
- Author
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Shifeng Yang, Xia Li, Baoting Chao, Lebin Wu, Zhaoping Cheng, Yanhua Duan, Dawei Wu, Yiqiang Zhan, Jiuhong Chen, Bo Liu, Xiaopeng Ji, Pei Nie, and Ximing Wang
- Subjects
Medicine ,Science - Abstract
OBJECTIVES: To evaluate the feasibility of dose-modulated retrospective ECG-gated thoracoabdominal aorta CT angiography (CTA) assessing abdominal aortic intimal flap motion and investigate the motion characteristics of intimal flap in acute aortic dissection (AAD). MATERIALS AND METHODS: 49 patients who had thoracoabdominal aorta retrospective ECG-gated CTA scan were enrolled. 20 datasets were reconstructed in 5% steps between 0 and 95% of the R-R interval in each case. The aortic intimal flap motion was assessed by measuring the short axis diameters of the true lumen and false lumen 2 cm above of celiac trunk ostium in different R-R intervals. Intimal flap motion and configuration was assessed by two independent observers. RESULTS: In these 49 patients, 37 had AAD, 7 had intramural hematoma, and 5 had negative result for acute aortic disorder. 620 datasets of 31 patients who showed double lumens in abdominal aorta were enrolled in evaluating intimal flap motion. The maximum and minimum true lumen diameter were 12.2 ± 4.1 mm (range 2.6 ∼ 17.4) and 6.7 ± 4.1 mm (range 0 ∼ 15.3) respectively. The range of intimal flap motion in all patients was 5.5 ± 2.6 mm (range 1.8 ∼ 10.2). The extent of maximum true lumen diameter decreased during a cardiac cycle was 49.5% ± 23.5% (range 12% ∼ 100%). The maximum motion phase of true lumen diameter was in systolic phase (5% ∼ 40% of R-R interval). Maximum and minimum intimal flap motion was at 15% and 75% of the R-R interval respectively. Intimal flap configuration had correlation with the phase of cardiac cycle. CONCLUSIONS: Abdominal intimal flap position and configuration varied greatly during a cardiac cycle. Retrospective ECG-gated thoracoabdominal aorta CTA can reflect the actual status of the true lumen and provide more information about true lumen collapse. This information may be helpful to diagnosis and differential diagnosis of dynamic abstraction.
- Published
- 2014
- Full Text
- View/download PDF
4. Specific genomic alterations and prognostic analysis of perihilar cholangiocarcinoma and distal cholangiocarcinoma
- Author
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Yuanwen Zheng, Yejun Qin, Wei Gong, Hongguang Li, Bin Li, Yu Wang, Baoting Chao, Shulei Zhao, Luguang Liu, Shuzhan Yao, Junping Shi, Xiaoliang Shi, Kai Wang, and Shifeng Xu
- Subjects
Oncology ,Gastroenterology ,Original Article ,neoplasms - Abstract
BACKGROUND: Cholangiocarcinoma (CCA), which consists of intrahepatic CCA (iCCA), perihilar CCA (pCCA), and distal CCA (dCCA), is an aggressive malignancy worldwide. PCCA and dCCA are often classified as extrahepatic CCA (exCCA). However, the differences in mutational characteristics between pCCA and dCCA remain unclear. METHODS: Deep sequencing targeting of 450 cancer genes was performed for genomic alteration detection. The tumor mutational burden (TMB) was measured by an algorithm developed in-house. Correlation analysis was conducted using Fisher’s exact test. RESULTS: FGFR2 and ERBB2 mutations mainly occurred in iCCA and exCCA, respectively. In exCCA, the frequencies of PIK3CA, FAT4, KDM6A, MDM2, and TCF7L2 mutations were significantly higher in pCCA compared to dCCA, while the frequencies of TP53 and KRAS mutations were markedly lower in pCCA than those in dCCA. The prognosis-related mutations were different among the CCA subtypes. NF1 mutation was associated with short disease-free survival (DFS) and overall survival (OS), and ERBB2 mutation was associated with short DFS in dCCA patients. Meanwhile, MAP2K4 mutation was associated with long DFS and OS, and TERT mutation was associated with short DFS in pCCA. A series of mutations in genes, including ARID1A, ARID2, SMAD4, TERT, TP53, and KRAS, were found to be associated with the TMB. CONCLUSIONS: In this study, we investigated the comprehensive genomic characterizations of CCA patients, identified the significant alterations in each subtype, and identified potential biomarkers for prognosis prediction. These results provide molecular evidence for the heterogeneity of CCA subtypes and evidence for further precision targeted therapy of CCA patients.
- Published
- 2021
5. Short-term effects of different PM2.5 ranges on daily all-cause mortality in Jinan, China
- Author
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Zhixiang Ma, Xiangwei Meng, Cai Chen, Baoting Chao, Chuanzhen Zhang, and Wei Li
- Subjects
Male ,Air Pollutants ,China ,Multidisciplinary ,Air Pollution ,Humans ,Female ,Particulate Matter ,Environmental Exposure ,Middle Aged ,Mortality - Abstract
To examine the effects of different PM2.5 concentration ranges on daily all-cause mortality, 8768 all-cause deaths were recorded in the database of the Shandong Provincial Hospital Affiliated to Shandong First Medical University. Data of air pollutants (PM2.5 and O3) concentration were provided by the Jinan Environment Monitoring Center. The relative risk of all-cause mortality was assessed using a quasi-Poisson regression model after adjusting for confounding factors. The concentrations of PM2.5 were divided into four ranges 0–35 μg/m3; 35–75 μg/m3; 75–115 μg/m3; 115–150 μg/m3. There was no significant relationship between PM2.5 exposure and all-cause deaths in individuals aged 3, 35–75 μg/m3, and 115–150 μg/m3 with a mortality increase of 1.07 (1.01, 1.13), 1.03 (1.00, 1.05), and 1.05 (1.01, 1.08), respectively. When the population aged ≥ 60 years was stratified into gender groups, exposure to PM2.5 in the range 0–35 μg/m3 increased the mortality risk in men but not women. All-cause mortality in women, but not men, increased significantly with exposure to PM2.5 in the ranges of 35–75, 75–115, and 115–150 μg/m3.
- Published
- 2021
6. Middle lobe preservation and fixation after right upper and lower lobectomy for synchronous lung cancer
- Author
-
Bingqing Yue, Baoting Chao, Weixia Ma, Hua Jiang, and Jiankai Wang
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Pleural effusion ,medicine.medical_treatment ,Lung cancer ,middle lobe preservation ,pulmonary bilobectomy ,pulmonary function ,Pulmonary function testing ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Technical Note ,Humans ,Pneumonectomy ,RC254-282 ,Phrenic nerve ,Aged ,Lung ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,General Medicine ,Middle Aged ,medicine.disease ,Lobe ,Surgery ,Chest tube ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,business ,Intercostal muscle - Abstract
The incidence of multiple lung cancer has been steadily increasing worldwide. Although cases of patients with lung cancers in the right upper and lower lobe have also become more frequently reported in clinical work, simultaneous right upper and lower lobectomy reports with the middle lobe preservation are still quite rare. A total of three patients with lung cancers in the right upper and lower lobe were included in the study. The patients underwent simultaneous right upper and lower lobectomy, whereas the remaining middle lobe was sutured and fixed to the intercostal muscle of the incision to prevent postoperative lobe torsion. There was no procedure to reduce residual space,such as phrenic nerve crush or thoracoplasty. All patients were discharged from the hospital 7 days after the operation. The chest tube was removed 5 days after the operation in two patients. One patient was discharged with the tube because of slight pulmonary leakage, and the tube was removed 2 weeks after the operation. Six months after the operation, the chest computer tomography showed that the middle lobe expanded well and no obvious cavity or pleural effusion was found. The suture of the remaining middle lobe and intercostal muscle of the incision is a simple and effective method that can be used to successfully avoid middle lobe torsion. This strategy is safe and can be used as the first choice for eligible patients., The patients with lung cancers in right upper and lower lobe have been found in clinical work. Right pneumonectomy has a higher risk of mortality than lobectomy. We found a new simple and effective method to fix the middle lobe after right upper and lower bilobectomy, and the method can be preferred as the first choice of surgical procedure for eligible patients in clinical work.
- Published
- 2021
7. MRI-based visualization of iron-labeled CD133+ human endothelial progenitor cells
- Author
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Baoting Chao and Jie Liu
- Subjects
Endocrinology, Diabetes and Metabolism ,Iron ,Clinical Biochemistry ,Cell ,Biology ,Biochemistry ,Inorganic Chemistry ,chemistry.chemical_compound ,In vivo ,Antigens, CD ,medicine ,Humans ,Iron complex ,Viability assay ,AC133 Antigen ,Progenitor cell ,Cytotoxicity ,Cells, Cultured ,Glycoproteins ,Stem Cells ,Biochemistry (medical) ,Endothelial Cells ,General Medicine ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,chemistry ,embryonic structures ,Immunology ,cardiovascular system ,Agarose ,Stem cell ,Peptides ,Biomedical engineering - Abstract
The objective of this study is to build up a kind of effective approach to multiply CD133+ endothelial progenitor cells (EPCs) and visualize cells by labeling with two FDA-approved agents based on MRI technique. CD133+ cells were separated by immunomagnetic microbeads selection and grew with serum-free medium. Seven days later, CD133+ cell production was collected and co-incubated with iron complex for 24 h for labeling. The iron-labeled cells were suspended into agarose gel and scanned by MRI for visualization. Labeled cells were also analyzed for cell viability. Iron can be effectively introduced into CD133+ EPCs plasma in culture and visualized by changing the MRI signal intensity. Iron had no influence on cell viability. Conclusion: Iron substance can be applied to label CD133+ cells without cytotoxicity and iron-labeled cells can be visualized by MRI image. Due to the non-invasive property and repeatability of MRI technology and this kind of method could be used for tracing in vivo stem cells in the future.
- Published
- 2008
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