1. Use of serum biomarkers in the diagnosis of traumatic brain injury
- Author
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Nadira Nabiyeva Çevik, Ali Korulmaz, Mehmet Alakaya, Barış Ten, Çağrı Eroğlan, Mehmet Burak Yavuz Çimen, and Ali Ertuğ Arslanköylü
- Subjects
traumatic brain injury ,biomarkers ,glial fibrillary acidic protein ,ubiquitin carboxyterminal hydrolase-like1 ,Pediatrics ,RJ1-570 - Abstract
Objective: Traumatic brain injury (TBI) is a leading cause of death and disability in the pediatric age group. This study aimed to investigate the effectiveness of serum S100 calcium-binding protein B (S100b), ubiquitin carboxyterminal hydrolase-like1 (UCH-L1), glial fibrillary acidic protein (GFAP), and neurofilament (NF) protein levels in predicting the diagnosis and prognosis of traumatic brain injury. Methods: The research comprised head trauma patients aged 1 month to 18 years hospitalized at Mersin University Faculty of Medicine between October 2018 and November 2019. We recorded the demographic data of the patients, the type of trauma, the treatments administered in the pediatric intensive care unit (PICU), the Glasgow Coma Scale (GCS), the Pediatric Trauma Score (PTS), and the computed cerebral tomography (CT) reports. S-100b protein, UCHL-1, GFAP, and NF levels of the patients and control group were checked. The correlation between serum levels of biomarkers and GCS, CT findings, Rotterdam score, and Glasgow Outcome Scale-Extended (GOS-E) score of the patients was analyzed statistically. Results: The study included 73 patients, 49 males and 24 females. Comparing the groups revealed no statistically significant correlation between GFAP and TBI (p>0.05). However, the correlation between S-100b, UCHL-1, and NF and patient groups was statistically significant (p
- Published
- 2024
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