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1. The safety of corticosteroid therapy in IGA nephropathy: analysis of a real-life Italian cohort

Author

Baragetti, Ivano, Del Vecchio, Lucia, Ferrario, Francesca, Alberici, Federico, Amendola, Andrea, Russo, Elisa, Ponti, Serena, Di Palma, Anna Maria, Pani, Antonello, Rollino, Cristiana, Giannese, Domenico, Boscutti, Giuliano, Sorrentino, Annasara, Colturi, Carla, Brunori, Giuliano, Lazzarin, Roberta, Catapano, Fausta, Cozzolino, Mario, Feriozzi, Sandro, and Pozzi, Claudio

Published
2024
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3. Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients

Author

Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Musiała, Aleksandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Woodman, Alistair, Ranghino, Andrea, Stucchi, Andrea, Jonsson, Andreas, Schneider, Andreas, Pignataro, Angelo, Schrander, Anita, Torp, Anke, McKeever, Anna, Szymczak, Anna, Blom, Anna-Lena, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Ullah, Asad, McLaren, Barbara, van Dam, Bastiaan, Iwig, Beate, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Rogland, Björn, Perras, Boris, Alessandra, Butti, Harron, Camille, Wallquist, Carin, Siegert, Carl, Barrett, Carla, Gaillard, Carlo, Garofalo, Carlo, Abaterusso, Cataldo, Beerenhout, Charles, O'Toole, Charlotte, Somma, Chiara, Marx, Christian, Summersgill, Christina, Blaser, Christof, D'alessandro, Claudia, Emde, Claudia, Zullo, Claudia, Pozzi, Claudio, Geddes, Colin, Verburgh, Cornelis, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Glowski, Deborah, McGlynn, Deborah, Vargas, Denes, Krieter, Detlef, Russo, Domenico, Fuchs, Dunja, Sands, Dympna, Hoogeveen, Ellen, Irmler, Ellen, Dimény, Emöke, Favaro, Enrico, Platen, Eva, Olczyk, Ewelina, Hoorn, Ewout, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Sundelin, Fredrik, Uhlin, Fredrik, Greco, Gaetano, Roy, Geena, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Hirst, Gillian, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Welander, Gunilla, Augustyniak-Bartosik, Hanna, Boots, Hans, Schmidt-Gürtler, Hans, King, Hayley, McNally, Helen, Schlee, Hendrik, Boom, Henk, Naujoks, Holger, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Miśkowiec-Wiśniewska, Ilona, Schlee, Ines, Capizzi, Irene, Hernandez, Isabel Bascaran, Baragetti, Ivano, Manitius, Jacek, Turner, Jane, Eijgenraam, Jan-Willem, Kooman, Jeroen, Beige, Joachim, Pondel, Joanna, Wilcox, Joanne, Berdeprado, Jocelyn, Röthele, Jochen, Wong, Jonathan, Rotmans, Joris, Banda, Joyce, Mazur, Justyna, Hahn, Kai, Jędrzejak, Kamila, Nowańska, Katarzyna, Blouin, Katja, Neumeier, Katrin, Jones, Kirsteen, Anding-Rost, Kirsten, Gröntoft, Knut-Christian, Oldrizzi, Lamberto, Haydock, Lesley, Vogt, Liffert, Wilkinson, Lily, Gesualdo, Loreto, Schramm, Lothar, Biancone, Luigi, Nowak, Łukasz, Raasveld, Maarten, Durlik, Magdalena, Magnano, Manuela, Vervloet, Marc, Ricardi, Marco, Carmody, Margaret, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Stendahl, Maria, Svensson, Maria, Weetman, Maria, van Buren, Marjolijn, Joinson, Martin, Ferraresi, Martina, Dutton, Mary, van Diepen, Merel, Matthews, Michael, Provenzano, Michele, Hopf, Monika, Malaguti, Moreno, Wuttke, Nadja, Morgan, Neal, Palmieri, Nicola, Frischmuth, Nikolaus, Bleakley, Nina, Murrone, Paola, Cockwell, Paul, Leurs, Paul, Roderick, Paul, Voskamp, Pauline, Kashioulis, Pavlos, Ichtiaris, Pawlos, Blankestijn, Peter, Kirste, Petra, Schulz, Petra, Mason, Phil, Kalra, Philip, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Sajith, Rincy, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Aign, Sabine, Cäsar, Sabine, van Esch, Sadie, Chapman, Sally, Biribauer, Sandra, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Manan, Sherin, Röser, Silke, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Boorsma, Siska, Heidenreich, Stefan, Melander, Stefan, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Palm, Stephanie, Konings, Stijn, Mathavakkannan, Suresh, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Dorota, Szyszkowska, Cicchetti, Teresa, Nieszporek, Teresa, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Rappa, Tiziana, Almquist, Tora, Stövesand, Torsten, Bahner, Udo, Jensen, Ulrika, Palazzo, Valentina, De Simone, Walter, Seeger, Wolfgang, Kuan, Ying, Heleniak, Zbigniew, Aydin, Zeynep, Ramspek, Chava L., Boekee, Rosemarijn, Evans, Marie, Heimburger, Olof, Snead, Charlotte M., Caskey, Fergus J., Torino, Claudia, Szymczak, Maciej, Krajewska, Magdalena, Drechsler, Christiane, Wanner, Christoph, Chesnaye, Nicholas C., Jager, Kitty J., Dekker, Friedo W., Snoeijs, Maarten G.J., and Rotmans, Joris I.

Published
2022
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5. Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients

Author

Ramspek, Chava L., primary, Boekee, Rosemarijn, additional, Evans, Marie, additional, Heimburger, Olof, additional, Snead, Charlotte M., additional, Caskey, Fergus J., additional, Torino, Claudia, additional, Porto, Gaetana, additional, Szymczak, Maciej, additional, Krajewska, Magdalena, additional, Drechsler, Christiane, additional, Wanner, Christoph, additional, Chesnaye, Nicholas C., additional, Jager, Kitty J., additional, Dekker, Friedo W., additional, Snoeijs, Maarten G.J., additional, Rotmans, Joris I., additional, van Diepen, Merel, additional, Cupisti, Adamasco, additional, Sagliocca, Adelia, additional, Ferraro, Alberto, additional, Musiała, Aleksandra, additional, Mele, Alessandra, additional, Naticchia, Alessandro, additional, Còsaro, Alex, additional, Woodman, Alistair, additional, Ranghino, Andrea, additional, Stucchi, Andrea, additional, Jonsson, Andreas, additional, Schneider, Andreas, additional, Pignataro, Angelo, additional, Schrander, Anita, additional, Torp, Anke, additional, McKeever, Anna, additional, Szymczak, Anna, additional, Blom, Anna-Lena, additional, De Blasio, Antonella, additional, Pani, Antonello, additional, Tsalouichos, Aris, additional, Ullah, Asad, additional, McLaren, Barbara, additional, van Dam, Bastiaan, additional, Iwig, Beate, additional, Antonio, Bellasi, additional, Di Iorio, Biagio Raffaele, additional, Rogland, Björn, additional, Perras, Boris, additional, Alessandra, Butti, additional, Harron, Camille, additional, Wallquist, Carin, additional, Siegert, Carl, additional, Barrett, Carla, additional, Gaillard, Carlo, additional, Garofalo, Carlo, additional, Abaterusso, Cataldo, additional, Beerenhout, Charles, additional, O'Toole, Charlotte, additional, Somma, Chiara, additional, Marx, Christian, additional, Summersgill, Christina, additional, Blaser, Christof, additional, D'alessandro, Claudia, additional, Emde, Claudia, additional, Zullo, Claudia, additional, Pozzi, Claudio, additional, Geddes, Colin, additional, Verburgh, Cornelis, additional, Bergamo, Daniela, additional, Ciurlino, Daniele, additional, Motta, Daria, additional, Glowski, Deborah, additional, McGlynn, Deborah, additional, Vargas, Denes, additional, Krieter, Detlef, additional, Russo, Domenico, additional, Fuchs, Dunja, additional, Sands, Dympna, additional, Hoogeveen, Ellen, additional, Irmler, Ellen, additional, Dimény, Emöke, additional, Favaro, Enrico, additional, Platen, Eva, additional, Olczyk, Ewelina, additional, Hoorn, Ewout, additional, Vigotti, Federica, additional, Ansali, Ferruccio, additional, Conte, Ferruccio, additional, Cianciotta, Francesca, additional, Giacchino, Francesca, additional, Cappellaio, Francesco, additional, Pizzarelli, Francesco, additional, Sundelin, Fredrik, additional, Uhlin, Fredrik, additional, Greco, Gaetano, additional, Roy, Geena, additional, Bigatti, Giada, additional, Marinangeli, Giancarlo, additional, Cabiddu, Gianfranca, additional, Hirst, Gillian, additional, Fumagalli, Giordano, additional, Caloro, Giorgia, additional, Piccoli, Giorgina, additional, Capasso, Giovanbattista, additional, Gambaro, Giovanni, additional, Tognarelli, Giuliana, additional, Bonforte, Giuseppe, additional, Conte, Giuseppe, additional, Toscano, Giuseppe, additional, Del Rosso, Goffredo, additional, Welander, Gunilla, additional, Augustyniak-Bartosik, Hanna, additional, Boots, Hans, additional, Schmidt-Gürtler, Hans, additional, King, Hayley, additional, McNally, Helen, additional, Schlee, Hendrik, additional, Boom, Henk, additional, Naujoks, Holger, additional, Masri-Senghor, Houda, additional, Murtagh, Hugh, additional, Rayner, Hugh, additional, Miśkowiec-Wiśniewska, Ilona, additional, Schlee, Ines, additional, Capizzi, Irene, additional, Hernandez, Isabel Bascaran, additional, Baragetti, Ivano, additional, Manitius, Jacek, additional, Turner, Jane, additional, Eijgenraam, Jan-Willem, additional, Kooman, Jeroen, additional, Beige, Joachim, additional, Pondel, Joanna, additional, Wilcox, Joanne, additional, Berdeprado, Jocelyn, additional, Röthele, Jochen, additional, Wong, Jonathan, additional, Rotmans, Joris, additional, Banda, Joyce, additional, Mazur, Justyna, additional, Hahn, Kai, additional, Jędrzejak, Kamila, additional, Nowańska, Katarzyna, additional, Blouin, Katja, additional, Neumeier, Katrin, additional, Jones, Kirsteen, additional, Anding-Rost, Kirsten, additional, Gröntoft, Knut-Christian, additional, Oldrizzi, Lamberto, additional, Haydock, Lesley, additional, Vogt, Liffert, additional, Wilkinson, Lily, additional, Gesualdo, Loreto, additional, Schramm, Lothar, additional, Biancone, Luigi, additional, Nowak, Łukasz, additional, Raasveld, Maarten, additional, Durlik, Magdalena, additional, Magnano, Manuela, additional, Vervloet, Marc, additional, Ricardi, Marco, additional, Carmody, Margaret, additional, Di Bari, Maria, additional, Laudato, Maria, additional, Sirico, Maria Luisa, additional, Stendahl, Maria, additional, Svensson, Maria, additional, Weetman, Maria, additional, van Buren, Marjolijn, additional, Joinson, Martin, additional, Ferraresi, Martina, additional, Dutton, Mary, additional, Matthews, Michael, additional, Provenzano, Michele, additional, Hopf, Monika, additional, Malaguti, Moreno, additional, Wuttke, Nadja, additional, Morgan, Neal, additional, Palmieri, Nicola, additional, Frischmuth, Nikolaus, additional, Bleakley, Nina, additional, Murrone, Paola, additional, Cockwell, Paul, additional, Leurs, Paul, additional, Roderick, Paul, additional, Voskamp, Pauline, additional, Kashioulis, Pavlos, additional, Ichtiaris, Pawlos, additional, Blankestijn, Peter, additional, Kirste, Petra, additional, Schulz, Petra, additional, Mason, Phil, additional, Kalra, Philip, additional, Cirillo, Pietro, additional, Dattolo, Pietro, additional, Acampora, Pina, additional, Sajith, Rincy, additional, Nigro, Rita, additional, Boero, Roberto, additional, Scarpioni, Roberto, additional, Sicoli, Rosa, additional, Malandra, Rosella, additional, Aign, Sabine, additional, Cäsar, Sabine, additional, van Esch, Sadie, additional, Chapman, Sally, additional, Biribauer, Sandra, additional, Navjee, Santee, additional, Crosbie, Sarah, additional, Brown, Sharon, additional, Tickle, Sheila, additional, Manan, Sherin, additional, Röser, Silke, additional, Savoldi, Silvana, additional, Bertoli, Silvio, additional, Borrelli, Silvio, additional, Boorsma, Siska, additional, Heidenreich, Stefan, additional, Melander, Stefan, additional, Maxia, Stefania, additional, Maffei, Stefano, additional, Mangano, Stefano, additional, Palm, Stephanie, additional, Konings, Stijn, additional, Mathavakkannan, Suresh, additional, Schwedler, Susanne, additional, Delrieux, Sylke, additional, Renker, Sylvia, additional, Schättel, Sylvia, additional, Dorota, Szyszkowska, additional, Cicchetti, Teresa, additional, Nieszporek, Teresa, additional, Stephan, Theresa, additional, Schmiedeke, Thomas, additional, Weinreich, Thomas, additional, Leimbach, Til, additional, Rappa, Tiziana, additional, Almquist, Tora, additional, Stövesand, Torsten, additional, Bahner, Udo, additional, Jensen, Ulrika, additional, Palazzo, Valentina, additional, De Simone, Walter, additional, Seeger, Wolfgang, additional, Kuan, Ying, additional, Heleniak, Zbigniew, additional, and Aydin, Zeynep, additional

Published
2022
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6. SARS-CoV-2 and Hemodialysis: diffusion and mortality in patients and health care team. Reflections from the Lombardy experience

Author

Rombolà, G, Heidempergher, M, Cornacchiari, M, Baragetti, I, Pieruzzi, F, Rombolà, Giuseppe, Heidempergher, Marco, Cornacchiari, Marina, Baragetti, Ivano, Pieruzzi, Federico, Rombolà, G, Heidempergher, M, Cornacchiari, M, Baragetti, I, Pieruzzi, F, Rombolà, Giuseppe, Heidempergher, Marco, Cornacchiari, Marina, Baragetti, Ivano, and Pieruzzi, Federico

Published
2021

7. Symptom Burden before and after Dialysis Initiation in Older Patients

Author

de Rooij, Esther N.M., Meuleman, Yvette, de Fijter, Johan W., Jager, Kitty J., Chesnaye, Nicholas C., Evans, Marie, Caskey, Fergus J., Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Dekker, Friedo W., Hoogeveen, Ellen K., Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Drechsler, Christiane, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Alessandra, Butti, Abaterusso, Cataldo, Somma, Chiara, D’alessandro, Claudia, Torino, Claudia, Zullo, Claudia, Pozzi, Claudio, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Russo, Domenico, Favaro, Enrico, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Greco, Gaetano, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Capizzi, Irene, Baragetti, Ivano, Oldrizzi, Lamberto, Gesualdo, Loreto, Biancone, Luigi, Magnano, Manuela, Ricardi, Marco, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Ferraresi, Martina, Provenzano, Michele, Malaguti, Moreno, Palmieri, Nicola, Murrone, Paola, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Cicchetti, Teresa, Rappa, Tiziana, Palazzo, Valentina, De Simone, Walter, Schrander, Anita, van Dam, Bastiaan, Siegert, Carl, Gaillard, Carlo, Beerenhout, Charles, Verburgh, Cornelis, Janmaat, Cynthia, Hoogeveen, Ellen, Hoorn, Ewout, Dekker, Friedo, Boots, Johannes, Boom, Henk, Eijgenraam, Jan-Willem, Kooman, Jeroen, Rotmans, Joris, Jager, Kitty, Vogt, Liffert, Raasveld, Maarten, Vervloet, Marc, van Buren, Marjolijn, van Diepen, Merel, Chesnaye, Nicholas, Leurs, Paul, Voskamp, Pauline, Blankestijn, Peter, van Esch, Sadie, Boorsma, Siska, Berger, Stefan, Konings, Constantijn, Aydin, Zeynep, Musiała, Aleksandra, Szymczak, Anna, Olczyk, Ewelina, Augustyniak-Bartosik, Hanna, Miśkowiec-Wiśniewska, Ilona, Manitius, Jacek, Pondel, Joanna, Jędrzejak, Kamila, Nowańska, Katarzyna, Nowak, Łukasz, Szymczak, Maciej, Durlik, Magdalena, Dorota, Szyszkowska, Nieszporek, Teresa, Heleniak, Zbigniew, Jonsson, Andreas, Blom, Anna-Lena, Rogland, Björn, Wallquist, Carin, Vargas, Denes, Dimény, Emöke, Sundelin, Fredrik, Uhlin, Fredrik, Welander, Gunilla, Hernandez, Isabel Bascaran, Gröntoft, Knut-Christian, Stendahl, Maria, Svensson, Maria, Evans, Marie, Heimburger, Olof, Kashioulis, Pavlos, Melander, Stefan, Almquist, Tora, Jensen, Ulrika, Woodman, Alistair, McKeever, Anna, Ullah, Asad, McLaren, Barbara, Harron, Camille, Barrett, Carla, O'Toole, Charlotte, Summersgill, Christina, Geddes, Colin, Glowski, Deborah, McGlynn, Deborah, Sands, Dympna, Caskey, Fergus, Roy, Geena, Hirst, Gillian, King, Hayley, McNally, Helen, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Turner, Jane, Wilcox, Joanne, Berdeprado, Jocelyn, Wong, Jonathan, Banda, Joyce, Jones, Kirsteen, Haydock, Lesley, Wilkinson, Lily, Carmody, Margaret, Weetman, Maria, Joinson, Martin, Dutton, Mary, Matthews, Michael, Morgan, Neal, Bleakley, Nina, Cockwell, Paul, Roderick, Paul, Mason, Phil, Kalra, Philip, Sajith, Rincy, Chapman, Sally, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Mathavakkannan, Suresh, and Kuan, Ying

Published
2022
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9. P0366SAFETY OF STEROID THERAPY IN IGA NEPHROPATHY: THE CLINICAL EXPERIENCE OF 48 NEPHROLOGY UNITS IN ITALY

Author

Baragetti, Ivano, primary, Ferrario, Francesca, primary, Alberici, Federico, primary, Amendola, Andrea, primary, Luise, Maria Carmen, primary, Sarcina, C, primary, Sorrentino, Anna Sara, primary, Rollino, Cristiana, primary, Giannese, Domenico, primary, Mancini, Elena, primary, Pola, Alessandra, primary, Cozzolino, Mario, primary, and Pozzi, Claudio, primary

Published
2020
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10. MO040LONG-TERM FOLLOW-UP OF IGA NEPHROPATHY PATIENTS AT HIGH RISK OF PROGRESSION ACCORDING TO THE THERAPEUTIC APPROACH EMPLOYED: A MULTICENTER RETROSPECTIVE STUDY OF 947 PATIENTS

Author

Alberici, Federico, primary, Baragetti, Ivano, primary, Ferrario, Francesca, primary, Ponti, Serena, primary, Salviani, Chiara, primary, Del Vecchio, Lucia, primary, Viazzi, Francesca, primary, Pani, Antonello, primary, Manno, Carlo, primary, Boscutti, Giuliano, primary, Di Cesare, Grazia, primary, and Pozzi, Claudio, primary

Published
2020
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11. The low-protein diet for chronic kidney disease: 8 years of clinical experience in a nephrology ward

Author

Baragetti, Ivano, primary, De Simone, Ilaria, primary, Biazzi, Cecilia, primary, Buzzi, Laura, primary, Ferrario, Francesca, primary, Luise, Maria Carmen, primary, Santagostino, Gaia, primary, Furiani, Silvia, primary, Alberghini, Elena, primary, Capitanio, Chiara, primary, Terraneo, Veronica, primary, Milia, Vicenzo La, primary, and Pozzi, Claudio, primary

Published
2019
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12. Association Between Renal Function and Troponin T Over Time in Stable Chronic Kidney Disease Patients

Author

Chesnaye, Nicholas C., primary, Szummer, Karolina, additional, Bárány, Peter, additional, Heimbürger, Olof, additional, Magin, Hasan, additional, Almquist, Tora, additional, Uhlin, Fredrik, additional, Dekker, Friedo W., additional, Wanner, Christoph, additional, Jager, Kitty J, additional, Evans, Marie, additional, Cupisti, Adamasco, additional, Sagliocca, Adelia, additional, Ferraro, Alberto, additional, Musiała, Aleksandra, additional, Mele, Alessandra, additional, Naticchia, Alessandro, additional, Còsaro, Alex, additional, Woodman, Alistair, additional, Ranghino, Andrea, additional, Stucchi, Andrea, additional, Jonsson, Andreas, additional, Schneider, Andreas, additional, Pignataro, Angelo, additional, Schrander, Anita, additional, Torp, Anke, additional, McKeever, Anna, additional, Szymczak, Anna, additional, Blom, Anna‐Lena, additional, De Blasio, Antonella, additional, Pani, Antonello, additional, Tsalouichos, Aris, additional, Ullah, Asad, additional, McLaren, Barbara, additional, van Dam, Bastiaan, additional, Iwig, Beate, additional, Antonio, Bellasi, additional, Iorio, Biagio Raffaele Di, additional, Rogland, Björn, additional, Perras, Boris, additional, Alessandra, Butti, additional, Harron, Camille, additional, Wallquist, Carin, additional, Siegert, Carl, additional, Barrett, Carla, additional, Gaillard, Carlo, additional, Abaterusso, Cataldo, additional, Beerenhout, Charles, additional, O'Toole, Charlotte, additional, Somma, Chiara, additional, Marx, Christian, additional, Drechsler, Christiane, additional, Summersgill, Christina, additional, Blaser, Christof, additional, D'alessandro, Claudia, additional, Emde, Claudia, additional, Torino, Claudia, additional, Zullo, Claudia, additional, Pozzi, Claudio, additional, Geddes, Colin, additional, Verburgh, Cornelis, additional, Janmaat, Cynthia, additional, Bergamo, Daniela, additional, Ciurlino, Daniele, additional, Motta, Daria, additional, Glowski, Deborah, additional, McGlynn, Deborah, additional, Vargas, Denes, additional, Krieter, Detlef, additional, Russo, Domenico, additional, Fuchs, Dunja, additional, Sands, Dympna, additional, Hoogeveen, Ellen, additional, Irmler, Ellen, additional, Dimény, Emöke, additional, Favaro, Enrico, additional, Platen, Eva, additional, Olczyk, Ewelina, additional, Hoorn, Ewout, additional, Vigotti, Federica, additional, Caskey, Fergus, additional, Ansali, Ferruccio, additional, Conte, Ferruccio, additional, Cianciotta, Francesca, additional, Giacchino, Francesca, additional, Cappellaio, Francesco, additional, Pizzarelli, Francesco, additional, Sundelin, Fredrik, additional, Greco, Gaetano, additional, Roy, Geena, additional, Porto, Gaetana, additional, Bigatti, Giada, additional, Marinangeli, Giancarlo, additional, Cabiddu, Gianfranca, additional, Hirst, Gillian, additional, Fumagalli, Giordano, additional, Caloro, Giorgia, additional, Piccoli, Giorgina, additional, Capasso, Giovanbattista, additional, Gambaro, Giovanni, additional, Tognarelli, Giuliana, additional, Bonforte, Giuseppe, additional, Conte, Giuseppe, additional, Toscano, Giuseppe, additional, Rosso, Goffredo Del, additional, Welander, Gunilla, additional, Augustyniak‐Bartosik, Hanna, additional, Boots, Johannes, additional, Schmidt‐Gürtler, Hans, additional, King, Hayley, additional, McNally, Helen, additional, Schlee, Hendrik, additional, Boom, Henk, additional, Naujoks, Holger, additional, Masri‐Senghor, Houda, additional, Murtagh, Hugh, additional, Rayner, Hugh, additional, Miśkowiec‐Wiśniewska, Ilona, additional, Schlee, Ines, additional, Capizzi, Irene, additional, Cäsar, Sabine, additional, Hernandez, Isabel Bascaran, additional, Baragetti, Ivano, additional, Manitius, Jacek, additional, Turner, Jane, additional, Eijgenraam, Jan‐Willem, additional, Kooman, Jeroen, additional, Beige, Joachim, additional, Pondel, Joanna, additional, Wilcox, Joanne, additional, Berdeprado, Jocelyn, additional, Röthele, Jochen, additional, Wong, Jonathan, additional, Rotmans, Joris, additional, Banda, Joyce, additional, Mazur, Justyna, additional, Hahn, Kai, additional, Jędrzejak, Kamila, additional, Nowańska, Katarzyna, additional, Blouin, Katja, additional, Neumeier, Katrin, additional, Jones, Kirsteen, additional, Anding‐Rost, Kirsten, additional, Gröntoft, Knut‐Christian, additional, Oldrizzi, Lamberto, additional, Haydock, Lesley, additional, Vogt, Liffert, additional, Wilkinson, Lily, additional, Gesualdo, Loreto, additional, Schramm, Lothar, additional, Biancone, Luigi, additional, Nowak, Łukasz, additional, Raasveld, Maarten, additional, Szymczak, Maciej, additional, Durlik, Magdalena, additional, Magnano, Manuela, additional, Vervloet, Marc, additional, Ricardi, Marco, additional, Carmody, Margaret, additional, Di Bari, Maria, additional, Laudato, Maria, additional, Sirico, Maria Luisa, additional, Stendahl, Maria, additional, Svensson, Maria, additional, Weetman, Maria, additional, van Buren, Marjolijn, additional, Joinson, Martin, additional, Ferraresi, Martina, additional, Dutton, Mary, additional, Postorino, Maurizio, additional, van Diepen, Merel, additional, Matthews, Michael, additional, Provenzano, Michele, additional, Hopf, Monika, additional, Malaguti, Moreno, additional, Wuttke, Nadja, additional, Morgan, Neal, additional, Palmieri, Nicola, additional, Frischmuth, Nikolaus, additional, Bleakley, Nina, additional, Murrone, Paola, additional, Cockwell, Paul, additional, Leurs, Paul, additional, Roderick, Paul, additional, Voskamp, Pauline, additional, Kashioulis, Pavlos, additional, Ichtiaris, Pawlos, additional, Blankestijn, Peter, additional, Kirste, Petra, additional, Schulz, Petra, additional, Mason, Phil, additional, Kalra, Philip, additional, Cirillo, Pietro, additional, Dattolo, Pietro, additional, Acampora, Pina, additional, Sajith, Rincy, additional, Nigro, Rita, additional, Boero, Roberto, additional, Scarpioni, Roberto, additional, Sicoli, Rosa, additional, Malandra, Rosella, additional, Aign, Sabine, additional, van Esch, Sadie, additional, Chapman, Sally, additional, Biribauer, Sandra, additional, Navjee, Santee, additional, Crosbie, Sarah, additional, Brown, Sharon, additional, Tickle, Sheila, additional, Manan, Sherin, additional, Röser, Silke, additional, Savoldi, Silvana, additional, Bertoli, Silvio, additional, Borrelli, Silvio, additional, Boorsma, Siska, additional, Heidenreich, Stefan, additional, Melander, Stefan, additional, Maxia, Stefania, additional, Maffei, Stefano, additional, Mangano, Stefano, additional, Palm, Stephanie, additional, Konings, Constantijn, additional, Mathavakkannan, Suresh, additional, Schwedler, Susanne, additional, Delrieux, Sylke, additional, Renker, Sylvia, additional, Schättel, Sylvia, additional, Dorota, Szyszkowska, additional, Cicchetti, Teresa, additional, Nieszporek, Teresa, additional, Stephan, Theresa, additional, Schmiedeke, Thomas, additional, Weinreich, Thomas, additional, Leimbach, Til, additional, Rappa, Tiziana, additional, Stövesand, Torsten, additional, Bahner, Udo, additional, Jensen, Ulrika, additional, Palazzo, Valentina, additional, De Simone, Walter, additional, Seeger, Wolfgang, additional, Kuan, Ying, additional, Heleniak, Zbigniew, additional, and Aydin, Zeynep, additional

Published
2019
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17. Kidney Failure Prediction Models: A Comprehensive External Validation Study in Patients with Advanced CKD

Author

Ramspek, Chava L., Evans, Marie, Wanner, Christoph, Drechsler, Christiane, Chesnaye, Nicholas C., Szymczak, Maciej, Krajewska, Magdalena, Torino, Claudia, Porto, Gaetana, Hayward, Samantha, Caskey, Fergus, Dekker, Friedo W., Jager, Kitty J., van Diepen, Merel, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Musiała, Aleksandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Woodman, Alistair, Ranghino, Andrea, Stucchi, Andrea, Jonsson, Andreas, Schneider, Andreas, Pignataro, Angelo, Schrander, Anita, Torp, Anke, McKeever, Anna, Szymczak, Anna, Blom, Anna-Lena, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Ullah, Asad, McLaren, Barbara, van Dam, Bastiaan, Iwig, Beate, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Rogland, Björn, Perras, Boris, Alessandra, Butti, Harron, Camille, Wallquist, Carin, Siegert, Carl, Barrett, Carla, Gaillard, Carlo, Garofalo, Carlo, Abaterusso, Cataldo, Beerenhout, Charles, O’Toole, Charlotte, Somma, Chiara, Marx, Christian, Summersgill, Christina, Blaser, Christof, D’alessandro, Claudia, Emde, Claudia, Zullo, Claudia, Pozzi, Claudio, Geddes, Colin, Verburgh, Cornelis, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Glowski, Deborah, McGlynn, Deborah, Vargas, Denes, Krieter, Detlef, Russo, Domenico, Fuchs, Dunja, Sands, Dympna, Hoogeveen, Ellen, Irmler, Ellen, Dimény, Emöke, Favaro, Enrico, Platen, Eva, Olczyk, Ewelina, Hoorn, Ewout, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Sundelin, Fredrik, Uhlin, Fredrik, Greco, Gaetano, Roy, Geena, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Hirst, Gillian, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Welander, Gunilla, Augustyniak-Bartosik, Hanna, Boots, Hans, Schmidt-Gürtler, Hans, King, Hayley, McNally, Helen, Schlee, Hendrik, Boom, Henk, Naujoks, Holger, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Miśkowiec-Wiśniewska, Ilona, Schlee, Ines, Capizzi, Irene, Bascaran Hernandez, Isabel, Baragetti, Ivano, Manitius, Jacek, Turner, Jane, Eijgenraam, Jan-Willem, Kooman, Jeroen, Beige, Joachim, Pondel, Joanna, Wilcox, Joanne, Berdeprado, Jocelyn, Röthele, Jochen, Wong, Jonathan, Rotmans, Joris, Banda, Joyce, Mazur, Justyna, Hahn, Kai, Jędrzejak, Kamila, Nowańska, Katarzyna, Blouin, Katja, Neumeier, Katrin, Jones, Kirsteen, Anding-Rost, Kirsten, Gröntoft, Knut-Christian, Oldrizzi, Lamberto, Haydock, Lesley, Vogt, Liffert, Wilkinson, Lily, Gesualdo, Loreto, Schramm, Lothar, Biancone, Luigi, Nowak, Łukasz, Raasveld, Maarten, Durlik, Magdalena, Magnano, Manuela, Vervloet, Marc, Ricardi, Marco, Carmody, Margaret, Di Bari, Maria, Laudato, Maria, Luisa Sirico, Maria, Stendahl, Maria, Svensson, Maria, Weetman, Maria, van Buren, Marjolijn, Joinson, Martin, Ferraresi, Martina, Dutton, Mary, van Diepen, Merel, Matthews, Michael, Provenzano, Michele, Hopf, Monika, Malaguti, Moreno, Wuttke, Nadja, Morgan, Neal, Palmieri, Nicola, Frischmuth, Nikolaus, Bleakley, Nina, Murrone, Paola, Cockwell, Paul, Leurs, Paul, Roderick, Paul, Voskamp, Pauline, Kashioulis, Pavlos, Ichtiaris, Pawlos, Blankestijn, Peter, Kirste, Petra, Schulz, Petra, Mason, Phil, Kalra, Philip, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Sajith, Rincy, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Aign, Sabine, Cäsar, Sabine, van Esch, Sadie, Chapman, Sally, Biribauer, Sandra, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Manan, Sherin, Röser, Silke, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Boorsma, Siska, Heidenreich, Stefan, Melander, Stefan, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Palm, Stephanie, Konings, Stijn, Mathavakkannan, Suresh, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Dorota, Szyszkowska, Cicchetti, Teresa, Nieszporek, Teresa, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Rappa, Tiziana, Almquist, Tora, Stövesand, Torsten, Bahner, Udo, Jensen, Ulrika, Palazzo, Valentina, De Simone, Walter, Seeger, Wolfgang, Kuan, Ying, Heleniak, Zbigniew, and Aydin, Zeynep

Published
2021
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18. The low-protein diet for chronic kidney disease: 8 years of clinical experience in a nephrology ward.

Author

Baragetti, Ivano, Simone, Ilaria De, Biazzi, Cecilia, Buzzi, Laura, Ferrario, Francesca, Luise, Maria Carmen, Santagostino, Gaia, Furiani, Silvia, Alberghini, Elena, Capitanio, Chiara, Terraneo, Veronica, Milia, Vicenzo La, and Pozzi, Claudio

Subjects
*LOW-protein diet, *CHRONIC kidney failure, *BODY mass index, *GLOMERULAR filtration rate, *DIETARY proteins
Abstract

Background Guidelines indicate that a low-protein diet (LPD) delays dialysis in severe chronic kidney disease (CKD). We assessed the value of these guidelines by performing a retrospective analysis in our renal clinical practice. Methods The analysis was performed from 1 January 2010 to 31 March 2018 in 299 CKD Stage 4 patients followed for 70 months in collaboration with a skilled nutritionist. The patients included 43 patients on a controlled protein diet (CPD) of 0.8 g/kg/day [estimated glomerular filtration rate (eGFR) 20–30 mL/min/1.73 m2 body surface (b.s.)], 171 patients on an LPD of 0.6 g/kg/day and 85 patients on an unrestricted protein diet (UPD) who were not followed by our nutritionist (LPD and UPD, eGFR <20 mL/min/1.73 m2 b.s.). Results eGFR was higher in CPD patients than in UPD and LPD patients (21.9 ± 7.4 mL/min/1.73 m2 versus 17.6 ± 8.00 mL/min/1.73 m2 and 17.1 ± 7.5 mL/min/1.73 m2; P = 0.008). The real daily protein intake was higher in UPD patients than in LPD and CDP patients (0.80 ± 0.1 g/kg/day versus 0.6 ± 0.2 and 0.63 ± 0.2 g/kg/day; P = 0.01). Body mass index (BMI) was stable in the LPD and CPD groups but decreased from 28.5 ± 4.52 to 25.4 ± 3.94 kg/m2 in the UPD group (P < 0.001). The renal survival of UPD, LPD and CPD patients was 47.1, 84.3 and 90.7%, respectively, at 30 months (P < 0.001), 42.4, 72.0 and 79.1%, respectively, at 50 months (P < 0.001) and 42.4, 64.1 and 74.4%, respectively, at 70 months (P < 0.001). The LPD patients started dialysis nearly 24 months later than the UPD patients. Diet was an independent predictor of dialysis [−67% of RR reduction (hazard ratio = 0.33; confidence interval 0.22–0.48)] together with a reduction in BMI. Conclusions An LPD recommended by nephrologists in conjunction with skilled dietitians delays dialysis and preserves nutritional status in severe CKD. [ABSTRACT FROM AUTHOR]

Published
2020
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19. New agents to reduce cholesterol levels: implications for nephrologists.

Author

Vecchio, Lucia Del, Baragetti, Ivano, and Locatelli, Francesco

Subjects
*BLOOD cholesterol, *CHOLESTEROL, *RNA interference, *CHRONIC kidney failure, *REDUCING agents
Abstract

Statins and ezetimibe effectively reduce the burden of cardiovascular (CV) disease in patients with chronic kidney disease (CKD). Unfortunately, many subjects still die or have CV events despite cholesterol-lowering therapy. This is particularly true in patients with more advanced CKD. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that induces the degradation of the low-density lipoprotein receptor by targeting it for lysosomal destruction. Its inhibition causes a dramatic fall in cholesterol levels on top of maximized statin therapy. This goal is obtained with different therapeutic approaches, spanning from monoclonal antibodies to non sense oligonucleotides and silencing RNA (siRNA). Two human, monoclonal antibodies are approved for clinical use; they are still very expensive. Both agents significantly lower cholesterol levels. Evolocumab and alirocumab reduce significantly the risk for CV disease without relevant safety issues. Inclisiran is an siRNA molecule that produces PCSK9-specific RNA silencing. Data from a Phase II study showed significant cholesterol-lowering efficacy. The experience accumulated so far is limited in the CKD population. PCSK9 inhibition also has the potential to reduce the burden of CV in this subset by obtaining a much greater decrease in serum cholesterol compared with statin therapy or ezetimibe. Doubts exist that this approach will improve the outcome of dialysis patients, in whom vascular calcifications predominate. [ABSTRACT FROM AUTHOR]

Published
2020
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22. Changes in Proteinuria and Side Effects of Corticosteroids Alone or in Combination with Azathioprine at Different Stages of IgA Nephropathy

Author

Sarcina, Cristina, primary, Tinelli, Carmine, additional, Ferrario, Francesca, additional, Pani, Antonello, additional, De Silvestri, Annalisa, additional, Scaini, Patrizia, additional, Del Vecchio, Lucia, additional, Alberghini, Elena, additional, Buzzi, Laura, additional, Baragetti, Ivano, additional, and Pozzi, Claudio, additional

Published
2016
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23. Ultrasound-Accelerated Thrombolysis: An Innovative Technique to Treat Native Arteriovenous Fistula Acute Thrombosis

Author

Buzzi, Laura, Alberghini, Elena, Ferrario, Francesca, Baragetti, Ivano, Santagostino, Gaia, Furiani, Silvia, Corghi, Enzo, Sarcina, Cristina, Terraneo, Veronica, Rastelli, Francesco, Gambirasio, Maria Cristina, Bacchini, Giuseppe, Pozzi, Claudio, Buzzi, Laura, Alberghini, Elena, Ferrario, Francesca, Baragetti, Ivano, Santagostino, Gaia, Furiani, Silvia, Corghi, Enzo, Sarcina, Cristina, Terraneo, Veronica, Rastelli, Francesco, Gambirasio, Maria Cristina, Bacchini, Giuseppe, and Pozzi, Claudio

Abstract

Native arteriovenous fistula (AVF) acute thrombosis is the first cause of vascular access failure. Different procedures can restore AVF patency: pharmacological thrombolysis, mechanical thrombolysis and surgical thrombectomy. At the same time vascular stenosis must always be found and treated by angioplasty. Direct thrombolysis with endovascular catheter with or without mechanical thrombolysis is becoming the treatment of first choice. Ultrasound-accelerated thrombolysis by the EkoSonic Endovascular System (EKOS) is an innovative technique: a multilumen catheter releases low-dose ultrasound energy in addition to thrombolytic infusion inside the thrombus. EKOS thrombolysis is faster, more effective and less dangerous than standard thrombolysis. This technique brings neither thrombus fracture or breakage nor hemolysis, so it is better than mechanical thrombolysis. Ultrasound-accelerated thrombolysis is used to treat acute arterious and deep venous thrombosis and massive pulmonary thromboembolism. We first used microsonic accelerated thrombolysis to treat a 20 cm long thrombosis of a distal radio-cephalic fistula involving the forearm superficial venous circle. EKOS® system permitted a rapid resolution of vein thrombosis, restored the forearm superficial venous circle patency without any injury and allowed an immediate use of the AVF for dialysis. After 15 months, the AVF is still patent and well functioning., Il trattamento della trombosi della FAV con vasi nativi, che è la causa più frequente della perdita dell'accesso vascolare, può avvalersi di diverse tecniche: trombolisi farmacologica, trombolisi meccanica e trombectomia chirurgica, cui associare la correzione della stenosi che ha provocato la trombosi. La trombolisi diretta mediante cateterismo endovascolare con o senza tombolisi meccanica sta diventando la terapia di prima scelta. La tombolisi accelerata microsonica (TAM) è un trattamento endovascolare innovativo: grazie all'emissione di ultrasuoni da parte di un catetere multilume che rilascia contemporaneamente il fibrinolitico all'interno del trombo, la TAM è più rapida, più efficace e più sicura rispetto alla sola fibrinolisi e, rispetto alla tombolisi meccanica, non è traumatica, ha un bassissimo rischio di embolizzazione e non provoca emolisi. La TAM, da poco impiegata nelle trombosi acute arteriose e venose profonde e nelle tromboembolie polmonari massive, è stata da noi utilizzata per la prima volta per trattare la trombosi acuta di una FAV radio-cefalica estesa all'intero circolo venoso superficiale dell'avambraccio per una lunghezza complessiva di 20 cm. La TAM è risultata una tecnica semplice, ben tollerata e mini-invasiva che ha reso utilizzabile la FAV subito dopo la tombolisi. Dopo 15 mesi, la FAV è pervia e funziona bene.

Published
2013

24. Trombolisi accelerata microsonica: trattamento innovativo della trombosi di una fistola artero-venosa nativa

Author

Buzzi, Laura, primary, Alberghini, Elena, additional, Ferrario, Francesca, additional, Baragetti, Ivano, additional, Santagostino, Gaia, additional, Furiani, Silvia, additional, Corghi, Enzo, additional, Sarcina, Cristina, additional, Terraneo, Veronica, additional, Rastelli, Francesco, additional, Gambirasio, Maria Cristina, additional, Bacchini, Giuseppe, additional, and Pozzi, Claudio, additional

Published
2013
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25. -374 T/A RAGE Polymorphism Is Associated with Chronic Kidney Disease Progression in Subjects Affected by Nephrocardiovascular Disease

Author

Baragetti, Ivano, primary, Norata, Giuseppe Danilo, additional, Sarcina, Cristina, additional, Baragetti, Andrea, additional, Rastelli, Francesco, additional, Buzzi, Laura, additional, Grigore, Liliana, additional, Garlaschelli, Katia, additional, Pozzi, Claudio, additional, and Catapano, Alberico Luigi, additional

Published
2013
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26. Ultrasound-accelerated thrombolysis: an innovative technique to treat native arteriovenous fistula acute thrombosis

Author

Buzzi, Laura, primary, Alberghini, Elena, additional, Ferrario, Francesca, additional, Baragetti, Ivano, additional, Santagostino, Gaia, additional, Furiani, Silvia, additional, Corghi, Enzo, additional, Sarcina, Cristina, additional, Terraneo, Veronica, additional, Rastelli, Francesco, additional, Gambirasio, Maria Cristina, additional, Bacchini, Giuseppe, additional, and Pozzi, Claudio, additional

Published
2013
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28. Reduction of the Homocysteine Plasma Concentration by Intravenously Administered Folinic Acid and Vitamin B12 in Uraemic Patients on Maintenance Haemodialysis

Author

Buccianti, Gherardo, primary, Bamonti Catena, Fabrizia, additional, Patrosso, Cristina, additional, Corghi, Enzo, additional, Novembrino, Cristina, additional, Baragetti, Ivano, additional, Lando, Giuliana, additional, De Franceschi, Michela, additional, and Maiolo, Anna Teresa, additional

Published
2001
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34. Reduction of the Homocysteine Plasma Concentration by Intravenously Administered Folinic Acid and Vitamin B12in Uraemic Patients on Maintenance Haemodialysis

Author

Buccianti, Gherardo, Bamonti Catena, Fabrizia, Patrosso, Cristina, Corghi, Enzo, Novembrino, Cristina, Baragetti, Ivano, Lando, Giuliana, De Franceschi, Michela, and Maiolo, Anna Teresa

Abstract

Background:Hyperhomocysteinaemia is an independent cardiovascular risk factor which can induce vascular lesions, thus contributing to the early development of atherosclerosis. Low-dose folic acid supplementation reduces the pretreatment homocysteine plasma levels by 25–35%. Recent studies report that higher intravenous or oral administration of the active form of folic acid reduces the homocysteine plasma concentration by nearly 70%. The reduction could also be influenced by the thermolabile variant of methylenetetrahydrofolate reductase (tMTHFR) and by the dialysis modality. Methods:A cross-sectional clinical study was performed to evaluate the effect of a drug containing folinic acid and vitamin B12 on the plasma homocysteine concentration and whether this variable could also be influenced by the presence of a genetic variant of the methionine pathway and the use of different dialysis modalities. The plasma homocysteine concentration was measured in 55 patients undergoing haemodialysis, 27 of whom have been treated intravenously for megaloblastic anaemia using a drug containing low concentrations of folinic acid and vitamin B12 at the end of each dialysis session for 6 months. The presence of tMTHFR was sought by molecular analysis, and the role of the dialysis modality was also investigated. Results:The patients given the folic acid treatment had lower homocysteine plasma levels than those not so treated. The plasma homocysteine concentration was significantly higher in the tMRHFR homozygotes than in the patients with a normal genotype, significantly lower in the treated than in the untreated homozygotes, and significantly higher in the untreated homozygotes than in the untreated subgroup with a normal genotype. The homocysteine level was also significantly lower in the patients who underwent convective haemodialysis than in those who received standard bicarbonate dialysis. Conclusions:A drug containing low concentrations of folinic acid combined with vitamin B12 using an intermittent intravenous regimen is effective in reducing the homocysteine plasma concentration in uraemic patients. The homocysteine levels seem also to depend on genotype and dialysis modality.

Published
2001
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35. Renal involvement in sarcoidosis: histological patterns and prognosis, an Italian survey.

Author

Rastelli F, Baragetti I, Buzzi L, Ferrario F, Benozzi L, Di Nardo F, Devoti E, Cancarini G, Mezzina N, Napodano P, Gallieni M, Santoro D, Buemi M, Pecchini P, Malberti F, Colombo V, Colussi G, Sabadini E, Remuzzi G, Argentiero L, Gesualdo L, Gatti G, Trevisani F, Slaviero G, Spotti D, Baraldi O, La Manna G, Pignone E, Saltarelli M, Heidempergher M, Tedesco M, Genderini A, Ferro M, Rollino C, Roccatello D, Guzzo G, Clari R, Barbara Piccoli G, Comotti C, Brunori G, Cameli P, Bargagli E, Rottoli P, Dugo M, Cristina Maresca M, Bertoli M, Giozzet M, Brugnano R, Giovanni Nunzi E, D'Amico M, Minoretti C, Acquistapace I, Colturi C, Minola E, Camozzi M, Tosoni A, Nebuloni M, Ferrario F, Dell'Antonio G, Cusinato S, Feriozzi S, and Pozzi C

Abstract

Background: Granulomatous interstitial nephritis in sarcoidosis (sGIN) is generally clinically silent, but in <1% causes acute kidney injury (AKI)., Methods: This Italian multicentric retrospective study included 39 sarcoidosis-patients with renal involvement at renal biopsy: 31 sGIN-AKI, 5 with other patterns (No-sGIN-AKI), 3 with nephrotic proteinuria. We investigate the predictive value of clinical features, laboratory, radiological parameters and histological patterns regarding steroid response. Primary endpoint: incident chronic kidney disease (CKD) beyond the 1°follow-up (FU) year; secondary endpoint: response at 1°line steroid therapy; combined endpoint: the association of initial steroid response and outcome at the end of FU., Results: Complete recovery in all 5 No-sGIN-AKI-patients, only in 45% (13/29) sGIN-AKI-patients (p=0.046) (one lost in follow-up, for another not available renal function after steroids). Nobody had not response. Primary endpoint of 22 sGIN-AKI subjects: 65% (13/20) starting with normal renal function developed CKD (2/22 had basal CKD; median FU 77 months, 15-300). Combined endpoint: 29% (6/21) had complete recovery and final normal renal function (one with renal relapse), 48% (10/21) had partial recovery and final CKD (3 with renal relapse, of whom one with basal CKD) (p=0.024). Acute onset and hypercalcaemia were associated to milder AKI and better recovery than subacute onset and patients without hypercalcaemia, women had better endpoints than men. Giant cells, severe interstitial infiltrate and interstitial fibrosis seemed negative predictors in terms of endpoints., Conclusions: sGIN-AKI-patients with no complete recovery at 1°line steroid should be treated with other immunosuppressive to avoid CKD, in particular if males with subacute onset and III stage-not hypercalcaemic AKI., Competing Interests: Special thanks to Jacqueline Rodriguez, who revised the manuscript for English language, and to Claudia Giuliani, for graphic support. We express gratitude to Immunopathology Group of Italian Society of Nephrology and to ACSI Onlus “Amici contro la Sarcoidosi Italia”, the Italian national society of Sarcoidosis patients.Francesco Rastelli and Ivano Baragetti were responsible for the work. Other authors contributed to the data collection and reviewed and revised the manuscript as supervisors.Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article., (Copyright: © 2021 SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES.)

Published
2021
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36. [Utility of computerized vascular access monitoring: a pilot study].

Author

Grasso G, Buzzi L, Gambirasio MC, Fabbrini P, and Baragetti I

Subjects
Humans, Pilot Projects, Renal Dialysis, Retrospective Studies, Vascular Patency, Arteriovenous Shunt, Surgical, Thrombosis
Abstract

The surveillance of a vascular access (VA) is of primary importance for its outcome and for the patients' survival. However, there is still confusion about its usefulness, who should make it (physician or nurse) and when, and what is the best functional test to use. This retrospective analysis reports our experience of VA monitoring; it is based on the collaboration between concept doctors and nurses and on parameters integration, realized with the help of a software for vascular access monitoring (SMAV) designed by us. The analysis confronts the data gathered on a group of 100 patients, 13 months before the adoption of the SMAV, and another 100 patients, 19 months after. Of these patients, 13 belonged to both groups and were "controls of themselves". The number of thrombosis and angioplasties (PTA) plummeted in the 19 months in which the SMAV was used, from 10 (10%; 0.008 thrombosis/patient month) to 1 (1%; 0.0005 thrombosis/patient month) (p <0.01) and from 49 (49%; 0.037 PTA/patient month) to 27 (27%; 0.014PTA/patient month) (p <0.05) respectively. In the 13 control patients, a reduction of 70% in the number of PTA (from 26 to 8) was observed. SMAV allowed us to integrate the many functional parameters, making it easy to share information, encouraging teamwork, strengthening professional skills, and favouring the best management of AVs. The result was a reduction in thrombotic events and, surprisingly, a reduction of the need for PTA, most likely thanks to the higher level of attention in the evaluation and puncture of AV., (Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.)

Published
2020

37. New agents to reduce cholesterol levels: implications for nephrologists.

Author

Del Vecchio L, Baragetti I, and Locatelli F

Subjects
Humans, Kidney Diseases metabolism, Kidney Diseases pathology, Nephrologists, Anticholesteremic Agents therapeutic use, Cardiovascular Diseases prevention & control, Cholesterol metabolism, Kidney Diseases drug therapy, PCSK9 Inhibitors
Abstract

Statins and ezetimibe effectively reduce the burden of cardiovascular (CV) disease in patients with chronic kidney disease (CKD). Unfortunately, many subjects still die or have CV events despite cholesterol-lowering therapy. This is particularly true in patients with more advanced CKD. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that induces the degradation of the low-density lipoprotein receptor by targeting it for lysosomal destruction. Its inhibition causes a dramatic fall in cholesterol levels on top of maximized statin therapy. This goal is obtained with different therapeutic approaches, spanning from monoclonal antibodies to non sense oligonucleotides and silencing RNA (siRNA). Two human, monoclonal antibodies are approved for clinical use; they are still very expensive. Both agents significantly lower cholesterol levels. Evolocumab and alirocumab reduce significantly the risk for CV disease without relevant safety issues. Inclisiran is an siRNA molecule that produces PCSK9-specific RNA silencing. Data from a Phase II study showed significant cholesterol-lowering efficacy. The experience accumulated so far is limited in the CKD population. PCSK9 inhibition also has the potential to reduce the burden of CV in this subset by obtaining a much greater decrease in serum cholesterol compared with statin therapy or ezetimibe. Doubts exist that this approach will improve the outcome of dialysis patients, in whom vascular calcifications predominate., (© The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)

Published
2020
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38. [Assisted peritoneal dialysis].

Author

Alberghini E, Rastelli F, Di Nardo R, Rognoni L, Gambirasio MC, Ferrario F, Furiani S, Corghi E, Baragetti I, Buzzi L, Santagostino G, De Simone I, Krefta A, and Pozzi C

Subjects
Home Care Services, Humans, Italy, Allied Health Personnel, Peritoneal Dialysis economics, Peritoneal Dialysis statistics & numerical data
Abstract

Peritoneal dialysis (PD) has a prevalence in Italy that does not exceed 10% of patients in substitution treatment. Among the barriers, which hinder access to DP, the lack of patient autonomy or family support has great importance. In 2012 in Lombardy, the lack of support has prevented 155 new patients to use DP and has forced 17 to stop it. According to the Italian Census of 2012, made by the Peritoneal Dialysis Study Group, Assisted DP involved the 24.5% of patients in 2010. In these cases, the caregiver was a family member in 80.8% of cases, a carer in 12.4%, a homecare nurse in 2.5% and the retirement home staff in 3.9%. In Italy, several regional Governments have sought to encourage home dialysis with economic contributions to the patient or the family. However, so far, none of these interventions has managed to increase the use of DP. In January 2004, we started a program of Assisted PD, using health worker as caregiver, in agreement with ASL Milano and ICP Milano Hospital. In the first 6 months of activity we treated 4 patients, 3 of them had been treated with hemodialysis. We had no critical cases and patients have welcomed this solution. In addition, the costs related to the Assisted PD are lower in comparison with the costs of the hospital hemodialysis. Considering the reliability of the first results, ASL has decided to raise the economic contribution for this activity, allowing us to increase the number of patients to include in Assisted PD.

Published
2014

39. [The ambiguous concept of predialysis: proposal for a model].

Author

Alberghini E, Gambirasio MC, Sarcina C, Biazzi C, Ferrario F, Corghi E, Baragetti I, Buzzi L, Visciano B, Terraneo V, Santagostino G, and Pozzi C

Subjects
Decision Making, Dietetics, Humans, Italy, Kidney Failure, Chronic diet therapy, Kidney Failure, Chronic nursing, Kidney Failure, Chronic psychology, Kidney Failure, Chronic surgery, Kidney Transplantation, Nephrology, Nurse's Role, Physician's Role, Renal Replacement Therapy, Teaching Materials, Terminology as Topic, Hemodialysis Units, Hospital organization & administration, Kidney Failure, Chronic therapy, Models, Theoretical, Patient Care Team, Patient Education as Topic methods
Abstract

In 2009, 90% of nephrology centers in Lombardy declared to have a ''predialysis'' outpatient department, without, however, specifying its meaning. Research carried out in 2008 among nephrology centers in Piemonte showed how ambiguous this term was. According to the 2007 EDTA-ERA Registry, about 68% of European nephrology centers stated that they had an outpatient department for stage 4-5 CKD patients, but no information was available about the role of patients in the choice of dialysis. It is known that when the predialysis phase is poorly managed, the patient's rehabilitation will be more difficult. Dissatisfaction with dialysis often leads to withdrawal from dialysis, as several registries have shown. For this reason, we created a predialysis course at our center, involving a nephrologist, a nurse, and a dietician. The nephrologist helps the patient choose the most suitable therapeutic strategy, which means that doctor and patient share the responsibility for the treatment choice. The offered options are hemodialysis, peritoneal dialysis, preemptive kidney transplant, and a conservative dietary-pharmacological program. The nurse plans at least 4 meetings: 1) to talk with the patient in order to get to know him or her and his/her family; 2) to provide information about the dialysis procedure and establish the patient's preferences; 3) to clear any doubts about the treatment and deliver a booklet with information about the chosen dialysis procedure; 4) to explain the chosen dialysis procedure; 5) to meet the patient after their preparation for dialysis (vascular access or peritoneal catheter). The dietician manages the dietary programs both for patients who are close to starting dialysis and those on a longlasting conservative program. The predialysis course includes a meeting among all those involved with the patient (nephrologists, nurses, dieticians) to exchange information with the purpose of shared evaluation and decision-making.

Published
2011

40. Plasma homocysteine levels and cardiovascular mortality in patients with end-stage renal disease.

Author

Buccianti G, Baragetti I, Bamonti F, Furiani S, Dorighet V, and Patrosso C

Subjects
Cardiovascular Diseases blood, Cardiovascular Diseases complications, Cholesterol, LDL blood, Female, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic therapy, Male, Middle Aged, Regression Analysis, Renal Dialysis, Risk Factors, Serum Albumin analysis, Survival Analysis, Cardiovascular Diseases mortality, Homocysteine blood, Kidney Failure, Chronic blood
Abstract

Hyperhomocysteinemia is considered an independent risk factor for atherosclerosis in patients with normal renal function. Plasma homocysteine (Hcy) is increased in patients with chronic renal failure (CRF) and could be linked to their high cardiovascular (CV) morbidity and mortality. We prospectively studied 77 patients (47 males and 30 females aged 62.85 +/- 1.53 yrs) who had been on maintenance hemodialysis (HD) (4 hr/x3/week) for 65.5 +/- 7.23 months. Patients were followed-up for 44 months. At baseline, blood samples were taken for hemoglobin (Hb), total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, serum calcium, serum phosphates, parathyroid hormone (PTH), Hcy, vitamin B12, serum and erythrocyte folate and methylentetrahydrofolate-reductase (t-MTH-FR) genotype determination. Plasma Hcy levels of patients were divided into four quartiles. The univariate analysis demonstrated a significant relationship between Hcy and diastolic blood pressure (BP) (r=0.45; p=0.003), and both plasma (r=-0.30; p=0.03) and erythrocyte (r=-0.48; p=0.01) folate levels and CV score (r=0.39; p=0.007). Kaplan-Meier analysis showed that the mortality rate due to CV events was statistically significantly higher in the 4th Hcy quartile (68%; 12 patients) vs. the 3rd quartile (12%; two patients), the 2nd quartile (28%; four patients) and the 1st quartile (14%; two patients) (log-rank test p=0.02). Cox's regression analysis for CV survival showed that Hcy was a positive CV mortality predictor (beta=0.02; hazard ratio=1.031; 95% confidence interval (95% CI): 1.013-1.050; p=0.001), while LDL cholesterol and albumin related negatively to CV mortality (LDL cholesterol: beta=-0.02; hazard ratio=0.095; 95% CI: 0.0957-0.0997; p=0.035; albumin: beta=-2.35; hazard ratio=0.097; 95% CI: 0.011-0.847; p=0.026). Our results show that Hcy is a strong independent mortality predictor in HD patients with a 3% increase in mortality for each 1 micromol/L increase in plasma Hcy concentration. This agrees with previous findings confirming the role of Hcy in predicting CV risk factors in uremic patients.

Published
2004

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