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1. Examination of Antibody Responses as a Measure of Exposure to Malaria in the Indigenous Batwa and Their Non-Indigenous Neighbors in Southwestern Uganda

Author

Kulkarni, MA, Garrod, G, Berrang Ford, L, Ssewanyana, I, Harper, SL, Baraheberwa, N, Donnelly, B, Patterson, K, Namanya, DB, Lwasa, S, and Drakeley, C

Subjects
parasitic diseases
Abstract

Understanding variations in malaria transmission and exposure is critical to identify populations at risk and enable better targeting of interventions. The indigenous Batwa of southwestern Uganda have a disproportionate burden of malaria infection compared with their non-indigenous neighbors. To better understand the individual- and community-level determinants of malaria exposure, a seroepidemiological study was conducted in 10 local council cells in Kanungu District, Uganda, in April 2014. The Batwa had twice the odds of being seropositive to two Plasmodium falciparum–specific antigens, apical membrane antigen-1 and merozoite surface protein-119, compared with the non-indigenous Bakiga (odds ratio = 2.08, 95% confidence interval = 1.51–2.88). This trend was found irrespective of altitude level and after controlling for cell location. Seroconversion rates in the Batwa were more than twice those observed in the Bakiga. For the Batwa, multiple factors may be associated with higher exposure to malaria and antibody levels relative to their non-indigenous neighbors.

Published
2016

2. Examination of Antibody Responses as a Measure of Exposure to Malaria in the Indigenous Batwa and Their Non-Indigenous Neighbors in Southwestern Uganda.

Author

Kulkarni MA, Garrod G, Berrang-Ford L, Ssewanyana I, Harper SL, Baraheberwa N, Donnelly B, Patterson K, Namanya DB, Lwasa S, and Drakeley C

Subjects
Adolescent, Adult, Antibodies, Protozoan immunology, Antigens, Protozoan immunology, Child, Child, Preschool, Female, Humans, Malaria, Falciparum epidemiology, Male, Membrane Proteins immunology, Merozoite Surface Protein 1 immunology, Population Groups statistics & numerical data, Protozoan Proteins immunology, Risk Factors, Seroepidemiologic Studies, Uganda epidemiology, Young Adult, Antibody Formation immunology, Malaria, Falciparum immunology
Abstract

Understanding variations in malaria transmission and exposure is critical to identify populations at risk and enable better targeting of interventions. The indigenous Batwa of southwestern Uganda have a disproportionate burden of malaria infection compared with their non-indigenous neighbors. To better understand the individual- and community-level determinants of malaria exposure, a seroepidemiological study was conducted in 10 local council cells in Kanungu District, Uganda, in April 2014. The Batwa had twice the odds of being seropositive to two Plasmodium falciparum -specific antigens, apical membrane antigen-1 and merozoite surface protein-1 19 , compared with the non-indigenous Bakiga (odds ratio = 2.08, 95% confidence interval = 1.51-2.88). This trend was found irrespective of altitude level and after controlling for cell location. Seroconversion rates in the Batwa were more than twice those observed in the Bakiga. For the Batwa, multiple factors may be associated with higher exposure to malaria and antibody levels relative to their non-indigenous neighbors., (© The American Society of Tropical Medicine and Hygiene.)

Published
2017
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