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2. A distal record of the Middle Miocene silicic eruption of the Carpathian-Pannonian Region stored within the Dinaride Lake System: implications for tephrostratigraphy and emplacement of volcaniclastic deposits

Author

Brlek, Mihovil, Trinajstić, Nina, Schindlbeck-Belo, Julie Christin, Kutterolf, Steffen, Vukovski, Matija, Guillong, Marcel, Markovic, Sava, Šuica, Sanja, Wang, Kuo-Lung, Lee, Hao-Yang, Gaynor, Sean P., Brčić, Vlatko, Mišur, Ivan, Grizelj, Anita, Kurečić, Tomislav, Lazar, Jasmina Martinčević, Milošević, Monika, Baranyi, Viktória, Kukoč, Duje, Gilg, H. Albert, Georgiev, Stoyan, and Lukács, Réka

Published
2024
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4. Gluing GAP to RAS Mutants: A New Approach to an Old Problem in Cancer Drug Development

Author

Ranđelović, Ivan, Nyíri, Kinga, Koppány, Gergely, Baranyi, Marcel, Tóvári, József, Kigyós, Attila, Timár, József, Vértessy, Beáta G., and Grolmusz, Vince

Subjects
Quantitative Biology - Biomolecules, Computer Science - Computational Engineering, Finance, and Science
Abstract

Mutated genes may lead to cancer development in numerous tissues. While more than 600 cancer-causing genes are known today, some of the most widespread mutations are connected to the RAS gene: RAS mutations are found in approximately 25% of all human tumors. Specifically, KRAS mutations are involved in the three most lethal cancers in U.S.: pancreatic ductal adenocarcinoma, colorectal adenocarcinoma, and lung adenocarcinoma. These cancers are among the most difficult to treat, and they are frequently excluded from chemotherapeutic attacks as hopeless cases. The mutated KRAS proteins have specific 3-dimensional conformations, which perturb functional interaction with the GAP protein on the GAP:RAS complex surface leading to a signaling cascade and uncontrolled cell growth. Here we describe a gluing docking method for finding small molecules that bind to both the GAP and the mutated KRAS molecules. These small molecules glue together the GAP and the mutated KRAS molecules and may serve as new cancer drugs for the most lethal, most difficult-to-treat carcinomas. As a proof of concept, we identify two new, drug-like small molecules with the new method: these compounds specifically inhibit the growth of PANC-1 cell line with KRAS mutation G12D in vitro and in vivo. Importantly, the two new compounds show significantly lower IC50 and higher specificity against the G12D KRAS mutant as compared to the recently described MRTX-1133 inhibitor against the G12D KRAS mutant.

Published
2023

6. Dipeptide metabolite, glutamyl-glutamate mediates microbe-host interaction to boost spermatogenesis

Author

Balázs Juhász, Krisztina Horváth, Dániel Kuti, Jian Shen, Annette Feuchtinger, Chaoyang Zhang, Ildikó Bata-Vidács, István Nagy, József Kukolya, Michael Witting, Mária Baranyi, Szilamér Ferenczi, Axel Walch, Na Sun, and Krisztina J. Kovács

Subjects
Medicine, Science
Abstract

Abstract The decrease in sperm count and infertility is a global issue that remains unresolved. By screening environmental bacterial isolates, we have found that a novel lactic acid bacterium, Lactiplantibacillus plantarum SNI3, increased testis size, testosterone levels, sperm count, sexual activity and fertility in mice that have consumed the bacteria for four weeks. The abundance of L. plantarum in the colon microbiome was positively associated with sperm count. Fecal microbiota transplantation (FMT) from L. plantarum SNI3-dosed mice improved testicular functions in microbiome-attenuated recipient animals. To identify mediators that confer pro-reproductive effects on the host, untargeted in situ mass spectrometry metabolomics was performed on testis samples of L. plantarum SNI3-treated and control mice. Enrichment pathway analysis revealed several perturbed metabolic pathways in the testis of treated mice. Within the testis, a dipeptide, glutamyl-glutamate (GluGlu) was the most upregulated metabolite following L. plantarum SNI3 administration. To validate the pro-reproductive feature of GluGlu, systemic and local injections of the dipeptide have been performed. γ-GluGlu increased sperm count but had no effect on testosterone. These findings highlight the role of γ-GluGlu in mediating spermatogenetic effects of L. plantarum on the male mouse host and –following relevant human clinical trials- may provide future tools for treating certain forms of male infertility.

Published
2024
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7. Differential effects of hypoxia on motility using various in vitro models of lung adenocarcinoma

Author

Sára Eszter Surguta, Marcell Baranyi, Laura Svajda, Mihály Cserepes, Ivan Ranđelović, Enikő Tátrai, Balázs Hegedűs, and József Tóvári

Subjects
Medicine, Science
Abstract

Abstract Lung cancer is the leading cause of cancer-related death globally. Metastasis is the most common reason of mortality in which hypoxia is suggested to have a pivotal role. However, the effect of hypoxia on the metastatic potential and migratory activity of cancer cells is largely unexplored and warrants detailed scientific investigations. Accordingly, we analyzed changes on cell proliferation and migratory activity both in single-cell migration and invasion under normoxic and hypoxic conditions in lung adenocarcinoma cell lines. Alterations in crucial genes and proteins associated with cellular response to hypoxia, epithelial-mesenchymal transition, proliferation and apoptosis were also analyzed. Generally, we observed no change in proliferation upon hypoxic conditions and no detectable induction of apoptosis. Interestingly, we observed that single-cell motility was generally reduced while invasion under confluent conditions using scratch assay was enhanced by hypoxia in most of the cell lines. Furthermore, we detected changes in the expression of EMT markers that are consistent with enhanced motility and metastasis-promoting effect of hypoxia. In summary, our study indicated cell line-, time of exposure- and migrational type-dependent effects of hypoxia in cellular proliferation, motility and gene expression. Our results contribute to better understanding and tackling cancer metastasis.

Published
2024
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11. Mapping protein binding sites by photoreactive fragment pharmacophores

Author

Ábrányi-Balogh, Péter, Bajusz, Dávid, Orgován, Zoltán, Keeley, Aaron B., Petri, László, Péczka, Nikolett, Szalai, Tibor Viktor, Pálfy, Gyula, Gadanecz, Márton, Grant, Emma K., Imre, Tímea, Takács, Tamás, Ranđelović, Ivan, Baranyi, Marcell, Marton, András, Schlosser, Gitta, Ashraf, Qirat F., de Araujo, Elvin D., Karancsi, Tamás, Buday, László, Tóvári, József, Perczel, András, Bush, Jacob T., and Keserű, György M.

Published
2024
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15. HUNCHEST-II contributes to a shift to earlier-stage lung cancer detection: final results of a nationwide screening program

Author

Kerpel-Fronius, Anna, Megyesfalvi, Zsolt, Markóczy, Zsolt, Solymosi, Diana, Csányi, Péter, Tisza, Judit, Kecskés, Anita, Baranyi, Beatrix, Csánky, Eszter, Dóka, Adrienn, Gálffy, Gabriella, Göcző, Katalin, Győry, Csilla, Horváth, Zsolt, Juhász, Tünde, Kállai, Árpád, Kincses, Zsigmond T., Király, Zsolt, Király-Incze, Enikő, Kostyál, László, Kovács, Anita, Kovács, András, Kuczkó, Éva, Makra, Zsuzsanna, Maurovich Horvát, Pál, Merth, Gabriella, Moldoványi, István, Müller, Veronika, Pápai-Székely, Zsolt, Papp, Dávid, Polgár, Csaba, Rózsa, Péter, Sárosi, Veronika, Szalai, Zsuzsanna, Székely, András, Szuhács, Marianna, Tárnoki, Dávid, Tavaszi, Gábor, Turóczi-Kirizs, Róbert, Tóth, László, Urbán, László, Vaskó, Attila, Vigh, Éva, Dome, Balazs, and Bogos, Krisztina

Published
2024
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17. Mapping protein binding sites by photoreactive fragment pharmacophores

Author

Péter Ábrányi-Balogh, Dávid Bajusz, Zoltán Orgován, Aaron B. Keeley, László Petri, Nikolett Péczka, Tibor Viktor Szalai, Gyula Pálfy, Márton Gadanecz, Emma K. Grant, Tímea Imre, Tamás Takács, Ivan Ranđelović, Marcell Baranyi, András Marton, Gitta Schlosser, Qirat F. Ashraf, Elvin D. de Araujo, Tamás Karancsi, László Buday, József Tóvári, András Perczel, Jacob T. Bush, and György M. Keserű

Subjects
Chemistry, QD1-999
Abstract

Abstract Fragment screening is a popular strategy of generating viable chemical starting points especially for challenging targets. Although fragments provide a better coverage of chemical space and they have typically higher chance of binding, their weak affinity necessitates highly sensitive biophysical assays. Here, we introduce a screening concept that combines evolutionary optimized fragment pharmacophores with the use of a photoaffinity handle that enables high hit rates by LC-MS-based detection. The sensitivity of our screening protocol was further improved by a target-conjugated photocatalyst. We have designed, synthesized, and screened 100 diazirine-tagged fragments against three benchmark and three therapeutically relevant protein targets of different tractability. Our therapeutic targets included a conventional enzyme, the first bromodomain of BRD4, a protein-protein interaction represented by the oncogenic KRasG12D protein, and the yet unliganded N-terminal domain of the STAT5B transcription factor. We have discovered several fragment hits against all three targets and identified their binding sites via enzymatic digestion, structural studies and modeling. Our results revealed that this protocol outperforms screening traditional fully functionalized and photoaffinity fragments in better exploration of the available binding sites and higher hit rates observed for even difficult targets.

Published
2024
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19. Targeting hypoxia in combination with paclitaxel to enhance therapeutic efficacy in breast and ovarian cancer

Author

Laura Svajda, Ivan Ranđelović, Sára Eszter Surguta, Marcell Baranyi, Mihály Cserepes, and József Tóvári

Subjects
Tumor hypoxia, Migration, Metastasis, Hypoxia targeted therapy, Combination therapy, Therapeutics. Pharmacology, RM1-950
Abstract

The poor vascularization of solid tumors results in oxygen-deprived areas within the tumor mass. This phenomenon is defined as tumor hypoxia and is considered to be a major contributor to tumor progression in breast and ovarian cancers due to hypoxia-cascade-promoted increased metastasizing capacity. Hence, targeting hypoxia is a strategic cancer treatment approach, however, the hypoxia-modulating drugs face several limitations in monotherapies. Here, we investigated the impact of the potent hypoxia-inducible factor inhibitory compound acriflavine on tumor cell proliferation, migration, and metabolism under hypoxic conditions. We identified that acriflavine inhibited the proliferation of breast and ovarian tumor cells. To model the potential benefits of additional hypoxia response inhibition next to standard chemotherapy, we combined acriflavine with a frequently used chemotherapeutic agent, paclitaxel. In most breast and ovarian cancer cell lines used, we identified additive effects between the two drugs. The most significant findings were detected in triple-negative breast cancer cell lines, where we observed synergism. The drug combination effectively impeded tumor growth and metastasis formation in an in vivo orthotopic triple-negative breast cancer model as well. Additionally, we demonstrated that an epithelial-mesenchymal transition inhibitory drug, rolipram, combined with acriflavine and paclitaxel, notably reduced the motility of hypoxic triple-negative breast cancer cells. In conclusion, we identified novel drug combinations that can potentially combat triple-negative breast cancer by inhibiting hypoxia signaling and hindering cell migration and metastasis formation.

Published
2024
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20. Using linked cohort data to help address residual confounding in analyses of population administrative data

Author

Richard Silverwood, Gergo Baranyi, Lisa Calderwood, Bianca De Stavola, George Ploubidis, and Katie Harron

Subjects
Demography. Population. Vital events, HB848-3697
Abstract

Objectives Analyses of population administrative data can often only be minimally adjusted due to the unavailability of a full set of control variables, leading to bias due to residual confounding. Cohort studies will often contain rich information on potential confounders but may not be sufficiently powered to meaningfully address the research question of interest. We aimed to use linked cohort data to help address residual confounding in analyses of population administrative data. Approach We propose a multiple imputation-based approach, introduced through application to simulated data. We then apply this approach to a real-world problem – examining the association between pupil mobility (changing schools at non-standard times) and Key Stage 2 attainment using data from the UK National Pupil Database (NPD). The limited control variables available in the NPD are supplemented by multiple measures of socioeconomic deprivation captured in linked Millennium Cohort Study (MCS) data. Results The proposed approach is observed to perform well when using simulated data. The association between pupil mobility and Key Stage 2 attainment was attenuated after supplementing the NPD analysis with information from linked MCS data, though with a decrease in precision. Conclusion We have demonstrated the potential of the proposed approach, but more work is required. Implications The principles underlying this innovative approach are widely applicable: any analysis of administrative data where confounder control is limited by the availability of information could potentially be strengthened by linking a subset of individuals into richer cohort data and leveraging the additional information to inform population-level analyses.

Published
2024
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21. Screening for psychological distress in childhood and mental health-related hospital attendance among young adults

Author

Gergo Baranyi, Katie Harron, Nasir Rajah, and Emla Fitzsimons

Subjects
Demography. Population. Vital events, HB848-3697
Abstract

Objectives The prevalence of mental disorders is high and increasing among children and young people. Investigating the relationship between self-reported poor mental health and mental health service utilisation can provide evidence on the benefits of universal screening, but longitudinal data is rare. Approach Data from a nationally representative English cohort (Next Steps) were linked to NHS Hospital Episode Statistics. GHQ-12 assessed psychological distress in Next Steps at age 15; participants were followed until their first mental health-related hospital presentations or were censored at the end of the study (age 27). Cox proportionate hazard models with survey weights estimated associations. Results Out of 4058 young people included in the analyses, 19% reported high levels of distress at age 15. During the 12-year follow-up, 5.3%, 2.9% and 2.7% of the participants had at least one mental disorder, drug/alcohol misuse and self-harm presentation, respectively, and 4.2% had a mental health treatment. Higher GHQ-12 scores were associated with mental disorder presentations (HR=1.10, 95% CI:1.04-1.16), and mental health treatments (HR=1.14, 95% CI:1.08-1.20). Associations were weaker for young people living in deprived areas, or if their main parent had lower education. Conclusions Adolescent psychological distress predicts subsequent hospital attendance in young adulthood, but there are treatment gaps in service utilisation among more disadvantaged individuals. Detecting youth with mental health difficulties through universal screening, may facilitate early intervention, improve life-course outcomes, and reduce secondary healthcare use. Implications Linked cohort and administrative data can improve our understanding on long-term healthcare utilisation and treatment needs.

Published
2024
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26. Analysis, Implementation, and Assessment of a Serious Game for Smoking Cessation: Investigating Design and Playtesting Outcomes

Author

Aigner, Christoph, Baranyi, René, Hoelbling, Dominik, Baur, Kevin, Zeillinger, Victoria, Grechenig, Thomas, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Costin, Hariton-Nicolae, editor, and Petroiu, Gladiola Gabriela, editor

Published
2024
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27. Causal Vector Autoregression Enhanced with Covariance and Order Selection

Author

Bolla, Marianna, Ye, Dongze, Wang, Haoyu, Ma, Renyuan, Frappier, Valentin, Thompson, William, Donner, Catherine, Baranyi, Máté, and Abdelkhalek, Fatma

Subjects
Statistics - Methodology, 15B05, 62M10, 65F99, 65F30
Abstract

A causal vector autoregressive (CVAR) model is introduced for weakly stationary multivariate processes, combining a recursive directed graphical model for the contemporaneous components and a vector autoregressive model longitudinally. Block Cholesky decomposition with varying block sizes is used to solve the model equations and estimate the path coefficients along a directed acyclic graph (DAG). If the DAG is decomposable, i.e. the zeros form a reducible zero pattern (RZP) in its adjacency matrix, then covariance selection is applied that assigns zeros to the corresponding path coefficients. Real life applications are also considered, where for the optimal order $p\ge 1$ of the fitted CVAR$(p)$ model, order selection is performed with various information criteria.

Published
2022

28. Rediscovering the unusual, solitary bryozoan Monobryozoon ambulans Remane, 1936: first molecular and new morphological data clarify its phylogenetic position

Author

Thomas Schwaha, Sebastian H. Decker, Christian Baranyi, and Ahmed J. Saadi

Subjects
Meiofauna, Heligoland, Solitary, Phylogenetic relationship, Solitary bryozoa, Mitogenome, Zoology, QL1-991
Abstract

Abstract Background One of the most peculiar groups of the mostly colonial phylum Bryozoa is the taxon Monobryozoon, whose name already implies non-colonial members of the phylum. Its peculiarity and highly unusual lifestyle as a meiobenthic clade living on sand grains has fascinated many biologists. In particular its systematic relationship to other bryozoans remains a mystery. Despite numerous searches for M. ambulans in its type locality Helgoland, a locality with a long-lasting marine station and tradition of numerous courses and workshops, it has never been reencountered until today. Here we report the first observations of this almost mythical species, Monobryozoon ambulans. Results For the first time since 1938, we present new modern, morphological analyses of this species as well as the first ever molecular data. Our detailed morphological analysis confirms most previous descriptions, but also ascertains the presence of special ambulatory polymorphic zooids. We consider these as bud anlagen that ultimately consecutively separate from the animal rendering it pseudo-colonial. The remaining morphological data show strong ties to alcyonidioidean ctenostome bryozoans. Our morphological data is in accordance with the phylogenomic analysis, which clusters it with species of Alcyonidium as a sister group to multiporate ctenostomes. Divergence time estimation and ancestral state reconstruction recover the solitary state of M. ambulans as a derived character that probably evolved in the Late Cretaceous. In this study, we also provide the entire mitogenome of M. ambulans, which—despite the momentary lack of comparable data—provides important data of a unique and rare species for comparative aspects in the future. Conclusions We were able to provide first sequence data and modern morphological data for the unique bryozoan, M. ambulans, which are both supporting an alcyonidioidean relationship within ctenostome bryozoans.

Published
2024
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29. Dual-Control Design

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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30. Preparation of TS Fuzzy Models for Further Design

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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31. Revealing the qLPV Structure Using the TS Fuzzy Model Transformation

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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32. Example II: TS Fuzzy Model Variants of the Aeroelastic Wing Section

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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33. Generalized TS Fuzzy Model Transformation

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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34. Example I: TS Fuzzy Model Variants of the TORA System

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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35. TP Grid Structure of Functions

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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36. TS Fuzzy Model Transformation

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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37. Pseudo TP/TS Fuzzy Model Transformation

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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38. Outline of the Book

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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39. Discretization Via Random and Rectangular Grids Leading to Bi-Linear Approximations

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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40. TP Model Transformation

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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41. How to Manipulate the Input Space

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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42. Notations and Basic Concepts

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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43. Key Messages of the Book

Author

Baranyi, Péter, Rudas, Imre J., Series Editor, Szakál, Anikó, Series Editor, Batyrshin, Ildar, Editorial Board Member, Bokor, József, Editorial Board Member, De Baets, Bernard, Editorial Board Member, Fujita, Hamido, Editorial Board Member, Fukuda, Toshio, Editorial Board Member, Harashima, Fumio, Editorial Board Member, Hirota, Kaoru, Editorial Board Member, Pap, Endre, Editorial Board Member, Wilamowski, Bogdan M., Editorial Board Member, Baranyi, P., Advisory Editor, Bodenhofer, U., Advisory Editor, Fichtinger, G., Advisory Editor, Fullér, R., Advisory Editor, Galántai, A., Advisory Editor, Hluchý, L., Advisory Editor, Jamshidi, M. O., Advisory Editor, Kelemen, J., Advisory Editor, Kocur, D., Advisory Editor, Korondi, P., Advisory Editor, Kovács, G., Advisory Editor, Kóczy, L. T., Advisory Editor, Madarász, L., Advisory Editor, Nguyen, CH. C., Advisory Editor, Petriu, E., Advisory Editor, Precup, R.-E., Advisory Editor, Preitl, S., Advisory Editor, Prostean, O., Advisory Editor, Puri, V., Advisory Editor, Sallai, G. Y., Advisory Editor, Somló, J., Advisory Editor, Takács, M., Advisory Editor, Tar, J., Advisory Editor, Ungvari, L., Advisory Editor, Várkonyi-Kóczy, A. R., Advisory Editor, Várlaki, P., Advisory Editor, Vokorokos, L., Advisory Editor, and Baranyi, Péter

Published
2023
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44. Effect of finned networks on PCM based battery thermal management system for cylindrical Li-ion batteries

Author

Hrishav Dey, Sukumar Pati, Pitambar R. Randive, and László Baranyi

Subjects
Battery thermal management systems, Finned networks, Li-ion batteries, Phase change materials, Engineering (General). Civil engineering (General), TA1-2040
Abstract

The present numerical work investigates the effect of finned structures on the passive thermal management of cylindrical Lithium-ion batteries. Novel hexagonal thermal conduction networks using metal fins are proposed. The electrochemical-thermal coupling for the numerical modeling is achieved using the Newman-Tiedemann-Gu-Kim (NTGK) semi-empirical method extended with the enthalpy model to incorporate phase change materials. Firstly, the effect of the different structures on the thermal behavior and the delivered capacity for a high discharge rate of 4 C is analyzed. The addition of base PCM (phase change materials) decreases the overall increase in temperature by about 71.9 %, and up to 75.58 % for the optimal thermal conduction network. The finned structures also show more temperature uniformity in the battery module. Next, the effect of the ambient temperature on the thermal performance of the proposed designs is shown. Further, the behavior of the enhanced system is studied under a stressed discharge rate of 6 C and an abuse discharge rate of 8 C. The study is further extended to examine the viability of the proposed battery thermal management system (BTMS) when the cell arrangement is externally shorted with a small resistance of 0.5 Ω. Based on the numerical analysis the proposed designs perform well.

Published
2024
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48. Internal dynamics of patent reference networks using the Bray–Curtis dissimilarity measure

Author

József Baranyi, Szilveszter Csorba, Zsuzsa Farkas, Tünde Pacza, and Ákos Józwiak

Subjects
Patents, Intellectual ecology, Technological development, Bray–Curtis dissimilarity, Network analysis, Emerging patterns, Computer engineering. Computer hardware, TK7885-7895, Information technology, T58.5-58.64, Electronic computers. Computer science, QA75.5-76.95
Abstract

Abstract Background Patents are indicators of technological developments. The science & technology categories, to which they are assigned to, form a directed, weighted network where the links are the references between patents belonging to the respective categories. This network can be conceived as a kind of intellectual ecology, lending itself to mathematical analyses analogous to those carried out in numerical ecology. The non-metric Bray–Curtis dissimilarity, commonly used in quantitative ecology, can be used to describe the internal dynamics of this network. Results While the degree-distribution of the network remained stable during the studied years, that of the sub-networks of with at least k links showed that k = 5 is a critical number of citations: this many are needed that the bias towards already highly cited works come into effect (preferential attachment). Using the d ij Bay-Curtis dissimilarity between nodes i and j, a surprising pattern emerged: the log-probability of a change in d ij during a quarter of year depended linearly, with a negative coefficient, on the magnitude of the change itself. Conclusions The developed methodology could be useful to detect emerging technological developments, to aid decisions, for example, on resource allocation. The pattern found on the internal dynamics of the system depends on the categorisation of the patents, therefore it can serve as an indicator when comparing different categorisation methods. Graphical Abstract

Published
2024
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49. Blood oxygen regulation via P2Y12R expressed in the carotid body

Author

András Iring, Mária Baranyi, Bernadett Iring-Varga, Paula Mut-Arbona, Zsuzsanna T. Gál, Dorina Nagy, László Hricisák, János Varga, Zoltán Benyó, and Beáta Sperlágh

Subjects
Chemoreceptor, Hypoxia, O2 sensing, Purinergic signalling, Signal transduction, Cardiorespiratory regulation, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Peripheral blood oxygen monitoring via chemoreceptors in the carotid body (CB) is an integral function of the autonomic cardiorespiratory regulation. The presence of the purinergic P2Y12 receptor (P2Y12R) has been implicated in CB; however, the exact role of the receptor in O2 sensing and signal transduction is unknown. Methods The presence of P2Y12R was established by immunoblotting, RT qPCR and immunohistochemistry. Primary glomus cells were used to assess P2Y12R function during hypoxia and hypercapnia, where monoamines were measured by HPLC; calcium signal was recorded utilizing OGB-1 and N-STORM Super-Resolution System. Ingravescent hypoxia model was tested in anaesthetized mice of mixed gender and cardiorespiratory parameters were recorded in control and receptor-deficient or drug-treated experimental animals. Results Initially, the expression of P2Y12R in adult murine CB was confirmed. Hypoxia induced a P2Y12R-dependent release of monoamine transmitters from isolated CB cells. Receptor activation with the endogenous ligand ADP promoted release of neurotransmitters under normoxic conditions, while blockade disrupted the amplitude and duration of the intracellular calcium concentration. In anaesthetised mice, blockade of P2Y12R expressed in the CB abrogated the initiation of compensatory cardiorespiratory changes in hypoxic environment, while centrally inhibited receptors (i.e. microglial receptors) or receptor-deficiency induced by platelet depletion had limited influence on the physiological adjustment to hypoxia. Conclusions Peripheral P2Y12R inhibition interfere with the complex mechanisms of acute oxygen sensing by influencing the calcium signalling and the release of neurotransmitter molecules to evoke compensatory response to hypoxia. Prospectively, the irreversible blockade of glomic receptors by anti-platelet drugs targeting P2Y12Rs, propose a potential, formerly unrecognized side-effect to anti-platelet medications in patients with pulmonary morbidities.

Published
2024
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50. Can smart city planning enhance the sustainable transition of the E.U. capitals? A project and strategy-based smart, sustainable performance analysis in the programming period 2014-2020

Author

Csete Mária Szalmáné and Baranyi Tímea

Subjects
smart urban policy, smart city, project-based evaluation, smart, sustainable urban performance assessment, Machine design and drawing, TJ227-240, Engineering machinery, tools, and implements, TA213-215
Abstract

Cities across the globe perceive their opportunities for digital transition pathways. This paper presents a project and strategy-based assessment of smart city ambitions in the light of sustainable urban development pathways in the European Union capitals considering the programming period 2014-2020. The purpose of the research is to understand better the smart city trends in Europe and identify any correlation between smart city and sustainability ambitions through the European capitals. The basis of the research was the official project result platforms of European funds with priorities related to smart cities. The collected best practices of transnational smart city projects provide statistics from the previous programming period and draw attention to the developing trends of smart city functions and the activity level of European capitals in the digital transition. Results show that between 2014 and 2020 nearly half of the capitals owned a specific smart city strategic document. Evaluating the smart urban performance of the capitals, it can be stated that most smart solutions were implemented related to mobility and environment in the previous period. Furthermore, it was also considered whether smart city projects could facilitate the shift toward sustainability. Based on the assessment of their planning strategies, a complex image of the European capitals has been revealed in their smart city development concepts; their strategic-level planning can be understood better, which is essential for policymaking in the era of digitalisation, identifying synergies with sustainable urban development ambitions, and monitoring the reached targets at the city level.

Published
2023
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