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3. Efficacy, feasibility and tolerability of ketogenic diet for the treatment of poor response to bariatric surgery

Author

Vinciguerra, F. (F.), Longhitano, S. (S.), Carrubba, N. (N.), Piazza, L. (L.), Di Stefano, C. (C.), Arpi, M. L. (M. L.), Baratta, R. (R.), Hagnäs, M. (M.), Frittitta, L. (L.), Vinciguerra, F. (F.), Longhitano, S. (S.), Carrubba, N. (N.), Piazza, L. (L.), Di Stefano, C. (C.), Arpi, M. L. (M. L.), Baratta, R. (R.), Hagnäs, M. (M.), and Frittitta, L. (L.)

Abstract

Purpose: Poor response to bariatric surgery, namely insufficient weight loss (IWL) or weight regain (WR), is a critical issue in the treatment of obesity. The purpose of our study was to assess the efficacy, feasibility, and tolerability of very low-calorie ketogenic diet (VLCKD) for the management of this condition. Methods: A real-life prospective study was conducted on twenty-two patients who experienced poor response after bariatric surgery and followed a structured VLCKD. Anthropometric parameters, body composition, muscular strength, biochemical analyses, and nutritional behavior questionnaires were evaluated. Results: A significant weight loss (mean 14.1 ± 4.8%), mostly due to fat mass, was observed during VLCKD with the preservation of muscular strength. The weight loss obtained allowed patients with IWL to reach a body weight significantly lower than that obtained at the post-bariatric surgery nadir and to report the body weight of patients with WR at the nadir observed after surgery. The significantly beneficial changes in nutritional behaviors and metabolic profiles were observed without variations in kidney and liver function, vitamins, and iron status. The nutritional regimen was well tolerated, and no significant side effects were detected. Conclusion: Our data demonstrate the efficacy, feasibility, and tolerability of VLCKD in patients with poor response after bariatric surgery.

Published
2023

6. Minore (Sottrazione internazionale)

Author

Almureden, E, Amagliani, R, Astone, F, Auletta, T, Azzarri, F, Balestra, L, Baratta, R, Bargelli, E, Bariatti, S, Bartoli, R, Battelli, E, Benigni, R, Bertolino, M, Bianca, M, Bugetti, M, Calogero, M, Campiglio, C, Carratta, A, Cipriani, N, Damascelli, D, del Tufo, M, Di Blase, A, Dilandro, A, Dimartino, A, Dirosa, G, Favilli, C, Garlati, L, Gigliotti, F, Gorgoni, M, Iannicelli, A, Lenzi, R, Lipari, N, Marella, MR, Martino, M, Merli, A, Morozzo, P, Paladini, M, Palazzo, M, Paradiso, M, Patti, S, Poliseno, B, Renda, A, Rimini, C, Salanitro, U, Sesta, M, Spadafora, A, Spena, A, Tuo, C, Viarengo, I, Macario, F, Honorati, C, Almureden, E, Amagliani, R, Astone, F, Auletta, T, Azzarri, F, Balestra, L, Baratta, R, Bargelli, E, Bariatti, S, Bartoli, R, Battelli, E, Benigni, R, Bertolino, M, Bianca, M, Bugetti, M, Calogero, M, Campiglio, C, Carratta, A, Cipriani, N, Damascelli, D, del Tufo, M, Di Blase, A, Dilandro, A, Dimartino, A, Dirosa, G, Favilli, C, Garlati, L, Gigliotti, F, Gorgoni, M, Iannicelli, A, Lenzi, R, Lipari, N, Marella, MR, Martino, M, Merli, A, Morozzo, P, Paladini, M, Palazzo, M, Paradiso, M, Patti, S, Poliseno, B, Renda, A, Rimini, C, Salanitro, U, Sesta, M, Spadafora, A, Spena, A, Tuo, C, Viarengo, I, Macario, F, and Honorati, C

Published
2022

11. Prevalence and clinical characteristics of children and adolescents with metabolically healthy obesity:role of insulin sensitivity

Author

Vinciguerra, F. (Federica), Tumminia, A. (Andrea), Baratta, R. (Roberto), Ferro, A. (Alfredo), Alaimo, S. (Salvatore), Hagnäs, M. (Maria), Graziano, M. (Marco), Vigneri, R. (Riccardo), and Frittitta, L. (Lucia)

Subjects
children, insulin resistance, nutritional and metabolic diseases, metabolically healthy obesity, adolescents, metabolic syndrome
Abstract

Obesity represents a major risk factor for metabolic disorders, but some individuals, “metabolically healthy” (MHO), show less clinical evidence of these complications, in contrast to “metabolically unhealthy” (MUO) individuals. The aim of this cross-sectional study is to assess the prevalence of the MHO phenotype in a cohort of 246 overweight/obese Italian children and adolescents, and to evaluate their characteristics and the role of insulin resistance. Homeostasis model assessment–insulin resistance (HOMA-IR), insulin sensitivity index (ISI), insulinogenic index (IGI) and disposition index (DI) were all calculated from the Oral Glucose Tolerance Test (OGTT). MHO was defined by either: (1) HOMA-IR < 2.5 (MHO-IRes), or (2) absence of the criteria for metabolic syndrome (MHO-MetS). The MHO prevalence, according to MHO-MetS or MHO-IRes criteria, was 37.4% and 15.8%, respectively. ISI was the strongest predictor of the MHO phenotype, independently associated with both MHO-IRes and MHO-MetS. The MHO-MetS group was further subdivided into insulin sensitive or insulin resistant on the basis of HOMA-IR (either < or ≥ 2.5). Insulin sensitive MHO-MetS patients had a better metabolic profile compared to both insulin resistant MHO-MetS and MUO-MetS individuals. These data underscore the relevance of insulin sensitivity to identifying, among young individuals with overweight/obesity, the ones who have a more favorable metabolic phenotype.

Published
2020

14. The economic impact of cultural events: a focus on residents’ expenditures

Author

Baratta, R., Cassia, F., Simeoni, F., and Vigolo, V.

Subjects
direct economic impact, committed participants, occasional participants, residents’ retained expenditures, cultural events, festivals, direct economic impact, committed participants, occasional participants, residents’ retained expenditures, cultural events, festivals, Settore SECS-P/08 - Economia e Gestione delle Imprese
Published
2019

33. Obesità

Author

Frittitta, Lucia, Baratta, R, and Nigro, A.

Published
2011

42. Il diritto applicabile dal Tribunale unificato: il coordinamento tra fonti e i rapporti tra accordo TUB e regolamento (UE) n. 1257/2012

Author

Baratta, R, Bosshard, N, De Miguel Asensio, P, Di Cataldo, V, Guglielmetti, G, Honorati, C, Modiano, M, Pocar, F., Ricolfi, M, Sandrini, L, Scuffi, M, Tavassi, M, HONORATI, COSTANZA, Baratta, R, Bosshard, N, De Miguel Asensio, P, Di Cataldo, V, Guglielmetti, G, Honorati, C, Modiano, M, Pocar, F., Ricolfi, M, Sandrini, L, Scuffi, M, Tavassi, M, and HONORATI, COSTANZA

Abstract

Uno dei punti di maggiore complessità del futuro quadro di tutela berevettuale è costituito dal diritto applicabile dal Tribunale unificato. L'art. 24 dell'accordo TUB indica una pluralità di fonti (diritto UE, diritto convenzionale, diritto nazionale) che devono essere coordinati tra loro. Il contributo in oggetto mira a esaminerne il funzionamento, soffermandosi in particolare sul meccanismo di cui all'art. 7 TUB che, nel disporre il rinvio (materiale) al diritto nazionale, giunge per tale via a rendere applicabile le norme poste dallo stesso TUB. Attenzione è dedicata anche all'ambito di applicazione lasciato alle diverse fonti nei casi di contraffazione e ai rapporti tra profili di giurisdizione e di legge applicabile., One of the crucial issues of the future patent system is the law applicable to patent protection as applied by the upcoming Unfied Patent Court. Article 24 UPCA prescribes application of EU law, treaty law (included but not limited to UPCA and EPA) and national law. All these rules need to be coordinated one with each other. The present study analyzes how such coordination will actually work in regard of different issues. It focus in particular on Article 7 UPCA mechanism as such rule, while prescribing a (material) referrral to national law, aims to make applicable the conventional rules set in the UPCA. Special consideration is also given to the scope of application of the different rules in regards of patent infringement and to the difficult relation between rules on jurisdiction and rules on applicable law.

Published
2014

45. Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Author

Bonora, E., Capaldo, B., Perin, P. C., Del Prato, S., De Mattia, G., Frittitta, L., Frontoni, S., Leonetti, F., Luzi, L., Marchesini, G., Marini, M. A., Natali, A., Paolisso, G., Piatti, P. M., Pujia, A., Solini, A., Vettor, R., Bonadonna, R. C., Ferrannini, E., Baratta, R., Graci, S., Bracaglia, D., Monti, L., Setola, E., Montalcini, T., Sesti, G., De Kreutzenberg, S. V., E. Bonora, B. Capaldo, P. Cavallo Perin, S. Del Prato, G. De Mattia, L. Frittitta, S. Frontoni, F. Leonetti, L. Luzi, G. Marchesini Reggiani, M.A. Marini, A. Natali, G. Paolisso, P.M. Piatti, A .Pujia, A. Solini, R. Vettor, R.C. Bonadonna, Bonora, E, Capaldo, B, Perin, Pc, DEL PRATO, S, DE MATTIA, G, Frittitta, L, Frontoni, S, Leonetti, F, Luzi, L, Marchesini, G, Marini, Ma, Natali, A, Paolisso, Giuseppe, Piatti, Pm, Pujia, A, Solini, A, Vettor, R, Bonadonna, Rc, and GROUP OF ITALIAN SCIENTISTS OF INSULIN RESISTANCE, Gisir

Subjects
Adult, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Medicine (miscellaneous), Settore MED/13 - Endocrinologia, chemistry.chemical_compound, Insulin resistance, High-density lipoprotein, Internal medicine, Hyperinsulinism, Hyperinsulinemia, Medicine, Humans, Insulin, Hyperuricemia, Triglycerides, Aged, Aged, 80 and over, Nutrition and Dietetics, business.industry, Hypertriglyceridemia, Cholesterol, HDL, blood pressure, HDL-cholesterol, insulin, insulin resistance, triglycerides, uric acid, nutritional and metabolic diseases, Middle Aged, medicine.disease, Lipids, Endocrinology, Blood pressure, chemistry, Uric acid, Cardiology and Cardiovascular Medicine, business
Abstract

Backgound and Aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in nondiabetic subjects. Methods and Results: A database of hyperinsulinemic euglycemic clamp carried out with standard technique (40 mU per min per square meter of body surface area) in nondiabetic Italian subjects has been recently established. In this database we evaluated the relationships existing between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in nondiabetic subjects with fasting plasma glucose

Published
2008

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