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16 results on '"Barbaglia, Matteo Nazzareno"'

1. SAT-524 Risk of hepatocellular carcinoma and death among cirrhotics who carry genetic variants of epidermal growth factor, Adiponutrin and 17β-Hydroxysteroid Dehydrogenase-13: a long-term cohort study

Author

De Benedittis, Carla, primary, Caldarone, Francesca, additional, Lepore, Maia, additional, Strada, Angelo, additional, Burlone, Michela, additional, Rigamonti, Cristina, additional, Smirne, Carlo, additional, Barbaglia, Matteo Nazzareno, additional, Minisini, Rosalba, additional, and Pirisi, Mario, additional

Published
2024
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3. Liquid biopsy for hepatocellular carcinoma: Preliminary results on the association between postoperative early recurrence and the expression pattern of circulating tumor cells

Author

Ciulli, Cristina, primary, Famularo, Simone, additional, Barbaglia, Matteo Nazzareno, additional, Salmi, Livia, additional, Carissimi, Francesca, additional, De Carlis, Luciano, additional, Minisini, Rosalba, additional, Romano, Fabrizio, additional, and Pirisi, Mario, additional

Published
2022
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4. Finding the seed of recurrence: Hepatocellular carcinoma circulating tumor cells and their potential to drive the surgical treatment

Author

Carissimi, Francesca, primary, Barbaglia, Matteo Nazzareno, additional, Salmi, Livia, additional, Ciulli, Cristina, additional, Roccamatisi, Linda, additional, Cordaro, Giuseppe, additional, Mallela, Venkata Ramana, additional, Minisini, Rosalba, additional, Leone, Biagio Eugenio, additional, Donadon, Matteo, additional, Torzilli, Guido, additional, Pirisi, Mario, additional, Romano, Fabrizio, additional, and Famularo, Simone, additional

Published
2021
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5. Sex differences in hepatitis C virus infection: characterisation of 17,?-estradiol-modulated antiviral defences in an HCV cell culture system

Author

BARBAGLIA, Matteo Nazzareno

Abstract

Chronic hepatitis C is one of the most widespread liver diseases in the world, with over 170 million individuals infected with the hepatitis C virus (HCV). Several clinical studies have observed a protective effect of female sex against HCV infection and HCV-related liver diseases. Our group have demonstrated that 17,?-estradiol (E2) is able to inhibit HCV life cycle in vitro but the antiviral mechanisms are still unknown. In the first part of the present study, we evaluated the E2-mediated activation of hepatocytes innate immunity. Several studies showed the relationship between hypoxia and E2 signaling pathway and the cellular hypoxic state appears to influence HCV infection and may play a significant role in viral hepatocarcinogenesis. In the second part of the study, we evaluated the relationship between HCV infection, hypoxia (induced by dimethyloxalylglycine (DMOG) treatment) and E2. We evaluated the persistence of the E2-mediated antiviral status after treatment removal and its impact on the infection susceptibility. The E2 antiviral activity loss resulted to be time-treatment dependent. Gene expression analysis of interferon-related genes was performed on E2-treated cells (w and w/o infection). We demonstrated that E2 up-regulate the innate immune gene transcription in na�ve or infected cells. Also the conditioned medium (CM) produced by HuH7 cells post E2 treatment showed antiviral properties. Adding to E2 and CM treatment the an inhibitor of the IFN-?/IFNAR interaction, we obtained the complete antiviral effect loss; demonstrating that the E2-induced antiviral agents are linked to the interferon type I system. In the second part of the study, we found that the DMOG exerts opposite effects on viral infection, depending on exposure timing. Using the estrogen receptor (ER) agonist (E2) and antagonist (fulvestrant) compounds in combination with DMOG, we demonstrated a mutual interaction between the ER pathway and DMOG treatment effect on viral infection.

Published
2021
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7. Interplay of PNPLA and HSD17B13 variants in modulating the risk of hepatocellular carcinoma among hepatitis C virus infected patients

Author

De Benedittis, Carla, primary, Crevola, Martina, additional, Mallela, Venkata Ramana, additional, Barbaglia, Matteo Nazzareno, additional, Fangazio, Stefano, additional, Elisa, Ceriani, additional, Bellan, Mattia, additional, Rigamonti, Cristina, additional, Minisini, Rosalba, additional, and Pirisi, Mario, additional

Published
2020
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8. Role of Gas6 and TAM Receptors in the Identification of Cardiopulmonary Involvement in Systemic Sclerosis and Scleroderma Spectrum Disorders

Author

Bellan, Mattia, primary, Dimagli, Arnaldo, additional, Piccinino, Cristina, additional, Giubertoni, Ailia, additional, Ianniello, Aurora, additional, Grimoldi, Federico, additional, Sguazzotti, Maurizio, additional, Nerviani, Alessandra, additional, Barini, Michela, additional, Carriero, Alessandro, additional, Smirne, Carlo, additional, Burlone, Michela Emma, additional, Rigamonti, Cristina, additional, Minisini, Rosalba, additional, Salmi, Livia, additional, Barbaglia, Matteo Nazzareno, additional, Castello, Luigi Mario, additional, Sola, Daniele, additional, Marino, Paolo, additional, Avanzi, Gian Carlo, additional, Pirisi, Mario, additional, and Sainaghi, Pier Paolo, additional

Published
2020
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9. Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients

Author

De Benedittis, Carla, primary, Bellan, Mattia, additional, Crevola, Martina, additional, Boin, Elena, additional, Barbaglia, Matteo Nazzareno, additional, Mallela, Venkata Ramana, additional, Ravanini, Paolo, additional, Ceriani, Elisa, additional, Fangazio, Stefano, additional, Sainaghi, Pier Paolo, additional, Burlone, Michela Emma, additional, Minisini, Rosalba, additional, and Pirisi, Mario, additional

Published
2020
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11. THU-187-Objective evidence of neurocognitive impairment associated with hepatitis C virus infection and of its regression after viral clearance with direct antivirals

Author

Vaghi, Gloria, primary, Barbaglia, Matteo Nazzareno, additional, Gori, Benedetta, additional, Strigaro, Gionata, additional, Burlone, Michela Emma, additional, Tondo, Giacomo, additional, Minisini, Rosalba, additional, Cantello, Roberto, additional, and Pirisi, Mario, additional

Published
2019
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13. Severity of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus: Relationship between Nongenetic Factors and PNPLA3/HSD17B13 Polymorphisms

Author

Bellan, Mattia, primary, Colletta, Cosimo, additional, Barbaglia, Matteo Nazzareno, additional, Salmi, Livia, additional, Clerici, Roberto, additional, Mallela, Venkata Ramana, additional, Castello, Luigi Mario, additional, Saglietti, Giuseppe, additional, Carnevale Schianca, Gian Piero, additional, Minisini, Rosalba, additional, and Pirisi, Mario, additional

Published
2019
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15. Gas6 as a predictor of esophageal varices in patients affected by hepatitis C virus related-chronic liver disease

Author

Bellan, Mattia, primary, Sainaghi, Pier Paolo, additional, Minh, Margherita Tran, additional, Minisini, Rosalba, additional, Molinari, Luca, additional, Baldrighi, Marco, additional, Salmi, Livia, additional, Barbaglia, Matteo Nazzareno, additional, Castello, Luigi Mario, additional, Ravanini, Paolo, additional, Avanzi, Gian Carlo, additional, and Pirisi, Mario, additional

Published
2018
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