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2 results on '"Barbara Paccaloni"'

1. A large series of molecular and serological specimens to evaluate mother-to-child SARS-CoV-2 transmission: a prospective study from the Italian Obstetric Surveillance System

Author

Edoardo Corsi Decenti, Michele Antonio Salvatore, Alessandro Mancon, Giuseppe Portella, Arianna Rocca, Caterina Vocale, Serena Donati, Irene Alberi, Gaia Maria Anelli, Federica Baltaro, Maria Bisulli, Stefano Brusa, Ilaria Cataneo, Irene Cetin, Marianna Cuomo, Pietro Dal Rì, Lidia Di Cerbo, Alice Ferretti, Maria Rita Gismondo, Gianpaolo Grisolia, Stefania Livio, Mariavittoria Locci, Francesca Malentacchi, Federico Mecacci, Barbara Paccaloni, Maria Federica Pedna, Enrica Perrone, Lucrezia Pignatti, Martina Piras, Alessandra Primavera, Valeria Savasi, Serena Simeone, Fabrizio Taddei, Roberta Tironi, and Arianna Torri

Subjects
SARS-CoV-2, COVID-19, Specimen handling, Serological test, Immunological response, Mother-to-child transmission, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: To assay the presence of the SARS-CoV-2 genome in vaginal, rectal, and placental swabs among pregnant women and in newborn nasopharyngeal swabs and to investigate the immunological response and maternal antibody transfer through the umbilical cord blood and milk of unvaccinated mothers. Methods: Vaginal, rectal, and placental specimens, maternal and neonatal serum, and milk were collected from a wide cohort of pregnant Italian women with confirmed SARS-CoV-2 infection admitted to the hospital between February 25, 2020 and June 30, 2021. Samples were tested in selected reference laboratories according to a shared interlaboratory protocol. Results: Among 1086 enrolled women, the SARS-CoV-2 positive rate detected in all specimens ranged from 0.7% to 8.4%. Respectively, 45.2% of maternal sera collected during pregnancy and 39.7% of those collected at birth tested positive for immunoglobulin G, whereas 50.5% tested positive among neonates. Nasopharyngeal swabs were positive in 0.8% of the newborns, and immunoglobulin G was detected in 3.0% of the milk samples. The highest immunological response was recorded within 30 days during pregnancy and within 60 days of birth and in the neonatal population. Conclusion: Vertical transmission should be considered a rare event; although, a good maternal immunological response and antibodies transfer throughout the umbilical cord blood was detected.

Published
2023
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2. Ultrasound screening for congenital pyelectasis in term pregnancies

Author

Antonio Farina, Barbara Paccaloni, Adolfo V. P. Cella, Valentina Ciardelli, Giulia Magini, Nicola Rizzo, Lucia Rinaldi, Gian Paolo Salvioli, Marcello Lanari, Luciano Bovicelli, Ciardelli V., Rizzo N., Lanari M., Farina A., Magini GM., Paccaloni B., Rinaldi L., Cella AV., Salvioli G., and Bovicelli L.

Subjects
medicine.medical_specialty, Routine ultrasound, Pregnancy Trimester, Third, Sensitivity and Specificity, Ultrasonography, Prenatal, Pyelectasis, Predictive Value of Tests, Pregnancy, Ultrasound screening, Humans, Medicine, Kidney Pelvis, Prospective cohort study, perinatal, Fetus, business.industry, Obstetrics, screening, Obstetrics and Gynecology, Predictive value, medicine.anatomical_structure, pyelectasi, Pediatrics, Perinatology and Child Health, Gestation, Female, Kidney Diseases, business, Renal pelvis
Abstract

The purpose of this study was to compare the role of antenatal ultrasound screening for congenital pyelectasis at term with postnatal screening. An ultrasonographic prospective study of 231 fetuses of low-risk pregnancies was performed, evaluating the renal pelvis at term (38 to 42 weeks gestation) and after birth (first and third months of life). Cut-off points used were 9 mm antenatally, and 10 and 12 mm, respectively postnatally, all in an anteroposterior view. A sensitivity of 20% and a specificity of 93.4% was obtained when comparing the antenatal versus the third-month scan, whereas when we compared the sonograms from the first versus the third month of life, we found a sensitivity of 60% and a specificity of 89.7%, with a positive predictive value of 14.7% in the first case and 25% in the second case. A p value < 0.001 was obtained when comparing the sensitivities; a p value of 0.2 was reported when comparing the specificities. Data on a comparative screening of the renal pelvis measured antenatally at term and postnatally do not exist. Although it is extremely feasible, the measurement of the fetal renal pelvis during the routine ultrasound scan at term of gestation seems of no benefit in terms of sensitivity and positive predictive values in identifying infants affected by congenital pyelectasis. Because of the low values of sensitivity obtained in our study, a screening program for the renal pelvis dilation both in fetuses and newborns cannot be recommended.

Published
2005

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