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The care and services offered in the treatment of active military personnel and veterans with PTSD take a variety of forms, ranging from residential to outpatient treatment programs. The differences in the organization of care between these programs make comparisons difficult; however, an intermediate alternative exists in the form of intensive outpatient programs (IOPs), whose organization and range of care are closer to that offered in residential programs. This review compares and evaluates the effectiveness of residential programs to that of IOPs in the treatment of PTSD in active military personnel and veterans. Nine databases were searched from September/November 2022 to include primary studies evaluating the treatment of PTSD in active military personnel and veterans in residential programs and IOPs. Results were summarized in a narrative synthesis. A meta-analysis using a random effects model examined changes in standardized mean differences in PTSD symptom scores at baseline and discharge. Thirty-two studies in 41 publications were included. There was a notable decrease in PTSD symptom scores at the end of treatment in both programs, and no significant difference was found between them. However, IOPs effectiveness may be influenced by patient type (active military personnel or veterans). Regardless, our results suggest a positive effect of both types of programs on reducing PTSD symptoms. It is essential to be aware of the constraints inherent in the literature on the subject, including the lack of comparative studies, the potential impact of comorbidities, and the differential response of active military personnel and veterans to similar treatments. [ABSTRACT FROM AUTHOR]

Background The exact impact of ageing on skeletal muscle phenotype and mitochondrial and lipid content remains controversial, probably because physical activity, which greatly influences muscle physiology, is rarely accounted for. The present study was therefore designed to investigate the effects of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, and mitochondrial and intramyocellular lipid content in men. Methods Recreationally active young adult (20-30 yo; YA); active (ACT) and sedentary (SED) middle-age (50-65 yo; MA-ACT and MA-SED); and older (65 + yo; 65 + ACT and 65 + SED) and pre-frail older (65 + PF) men were recruited. Muscle biopsies from the vastus lateralis were collected to assess, on muscle cross sections, muscle phenotype (using myosin heavy chain isoforms immunolabelling), the fibre type-specific content of mitochondria (by quantifying the succinate dehydrogenase stain intensity), and the fibre type-specific lipid content (by quantifying the Oil Red O stain intensity). Results Only 65 + SED and 65 + PF displayed significantly lower overall and type IIa fibre sizes vs. YA. 65 + SED displayed a lower type IIa fibre proportion vs. YA. MA-SED and 65 + SED displayed a higher hybrid type IIa/IIx fibre proportion vs. YA. Sedentary and pre-frail, but not active, men displayed lower mitochondrial content irrespective of fibre type vs. YA. 65 + SED, but not 65 + ACT, displayed a higher lipid content in type I fibres vs. YA. Finally, mitochondrial content, but not lipid content, was positively correlated with indices of muscle function, functional capacity, and insulin sensitivity across all subjects. Conclusions Taken altogether, our results indicate that ageing in sedentary men is associated with (i) complex changes in muscle phenotype preferentially affecting type IIa fibres; (ii) a decline in mitochondrial content affecting all fibre types; and (iii) an increase in lipid content in type I fibres. They also indicate that physical activity partially protects from the effects of ageing on muscle phenotype, mitochondrial content, and lipid accumulation. No skeletal specific muscle phenotype of pre-frailty was observed. [ABSTRACT FROM AUTHOR]

Background Sarcopenic obese (SO) individuals are a unique subset of subjects that combines obesity and sarcopenia. Traditional weight loss programmes including aerobic exercises may worsen their condition by further reducing their lean mass. The objective of this observational and retrospective study was to verify the effect of a mixed weight loss programme combining caloric restriction and exercise on body composition, and lipid-lipoprotein profile of obese women according to their sarcopenic status. Methods One hundred and forty-six obese women (body mass index ≥ 30 kg/m2 and fat mass ≥ 40%) participated to the 3 week usual and institutionalized weight-reducing programme combining a dietary plan (1400 ± 200 kcal/day) and aerobic exercise (1 h/day, 6 days/week) of a specialized medical institution. The lean body mass index (LMI; lean mass/height2) was calculated, and women in the lowest tertile of LMI were considered SO. Results At baseline, SO women were older, and their body weight and LMI were lower than non-sarcopenic obese (N-SO) women ( p < 0.05). N-SO and SO women similarly lost fat mass and improved their lipid-lipoprotein profile ( p < 0.05), while differences in LMI between groups persisted at the end of the weight-reducing programme. Indeed, N-SO women lost lean mass ( p < 0.05) while SO did not. Conclusions These findings suggest that a short weight loss programme combining caloric restriction and aerobic exercise may significantly reduce fat mass and improve lipid-lipoprotein profile in obese women, independently of their sarcopenic status. Such programmes may have deleterious effects on lean mass in N-SO subjects, only. [ABSTRACT FROM AUTHOR]

Mitochondrial dysfunction is implicated in skeletal muscle atrophy and dysfunction with aging, with strong support for an increased mitochondrial-mediated apoptosis in sedentary rodent models. Whether this applies to aged human muscle is unknown, nor is it clear whether these changes are caused by sedentary behavior. Thus, we examined mitochondrial function [respiration, reactive oxygen species (ROS) emission, and calcium retention capacity (CRC)] in permeabilized myofibers obtained from vastus lateralis muscle biopsies of healthy physically active young (23.7±2.7 yr; mean±SD) and older (71.2±4.9 yr) men. Although mitochondrial ROS and maximal respiratory capacity were unaffected, the acceptor control ratio was reduced by 18% with aging, suggesting mild uncoupling of oxidative phosphorylation. CRC was reduced by 50% with aging, indicating sensitization of the mitochondrial permeability transition pore (mPTP) to apoptosis. Consistent with the mPTP sensitization, older muscles showed a 3-fold greater fraction of endonuclease G (a mitochondrial proapoptotic factor)-positive myonuclei. Aged muscles also had lower mitophagic potential, based on a 43% reduction in Parkin to the voltagedependent anion channel (VDAC) protein ratio. Collectively, these results show that mitochondrial-mediated apoptotic signaling is increased in older human muscle and suggest that accumulation of dysfunctional mitochondria with exaggerated apoptotic sensitivity is due to impaired mitophagy.--Gouspillou, G., Sgarioto, N., Kapchinsky, S., Purves-Smith, F., Norris, B., Pion, C. H., Barbat-Artigas, S., Le mieux, F., Taivassalo, T., Morais, J. A., Aubertin-Leheudre, M., Hepple, R. T. Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans. [ABSTRACT FROM AUTHOR]

Background: Obesity has been associated with metabolic complications. However, two subgroups of obese individuals (namely 'sarcopenic obese' and 'metabolically healthy but obese' individuals) with low muscle mass appear to have a better metabolic profile. Despite having a lower muscle mass, these individuals appear to have higher muscle strength, suggesting higher muscle quality. Studies have reported insulin sensitivity to be related to muscle quality. Therefore, the aim of the present study was to test the hypothesis that low muscle mass was associated with better muscle quality in obese individuals. Methods: A total of 112 postmenopausal women aged between 50 and 77 years (means, 61±6 years) were recruited. Body composition (bioelectrical impedancemetry), muscle strength (hand dynamometer), and functional capacity (chair stand test, alternate step test and balance test) were measured. Results: Skeletal muscle mass (SM; kg) was significantly positively correlated with muscle strength (kg) in normal weight ( r=0.43; P=0.003) and overweight ( r=0.42; P=0.020) women, but not in obese ( r=0.28; P=0.13) women. Muscle mass (kg) was significantly negatively correlated with muscle quality (kg/SMkg) in normal weight ( r=−0.41, P=0.005), overweight ( r=−0.59; P<0.001) and obese ( r=−0.59; P<0.001) individuals. Skeletal muscle mass index (kg/m2) was significantly negatively correlated with muscle quality in normal weight ( r=−0.33, P=0.025), overweight ( r=−0.47, P=0.008), and obese ( r=−0.43, P=0.015) women. Finally, type II sarcopenic individuals had higher muscle quality than type I sarcopenic ( P=0.002) and nonsarcopenic ( P=0.001) individuals. Conclusions: Our results support our hypothesis and showed that muscle quality increased as muscle mass and muscle mass index decreased. Thus, muscle quality may potentially explain the favorable metabolic profile observed in metabolically healthy but obese and sarcopenic obese postmenopausal women. Further studies including metabolic data are needed to confirm our results. [ABSTRACT FROM AUTHOR]