1,399 results on '"Barbato, E"'
Search Results
2. Physiological and angiographic outcomes of PCI in calcified lesions after rotational atherectomy or intravascular lithotripsy
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Gallinoro, E., Monizzi, G., Sonck, J., Candreva, A., Mileva, N., Nagumo, S., Munhoz, D., Buytaert, D., Mastrangelo, A., Andreini, D., Galli, S., Bartorelli, A.L., Barbato, E., De Bruyne, B., and Collet, C.
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- 2022
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3. Ten‐Year Outcome of Recanalization or Medical Therapy for Concomitant Chronic Total Occlusion After Myocardial Infarction
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van Veelen, Anna, primary, Coerkamp, Casper F., additional, Somsen, Yvemarie B.O., additional, Råmunddal, Truls, additional, Ioanes, Dan, additional, Laanmets, Peep, additional, van der Schaaf, René J., additional, Eriksen, Erlend, additional, Bax, Matthijs, additional, Suttorp, Maarten Jan, additional, Strauss, Bradley H., additional, Barbato, Emanuele, additional, Marques, Koen M., additional, Meuwissen, Martijn, additional, Bertrand, Olivier, additional, van der Ent, Martin, additional, Knaapen, Paul, additional, Tijssen, Jan G.P., additional, Claessen, Bimmer E.P.M., additional, Hoebers, Loes P.C., additional, Elias, Joëlle, additional, Henriques, José P.S., additional, Henriques, J.P.S., additional, Piek, J.J., additional, de Winter, R.J., additional, Koch, K.T., additional, Vis, M.M., additional, Baan, J., additional, Wykrzykowska, J., additional, Marques, K.M., additional, Meuwissen, M., additional, Koolen, J., additional, Bax, M., additional, Schotborgh, C.E., additional, van der Ent, M., additional, van der Schaaf, R.J., additional, Slagboom, T., additional, Amoroso, G., additional, Suttorp, M.J., additional, Råmunddal, T., additional, Ioanes, D., additional, Laanmets, P., additional, Eriksen, E., additional, Tuseth, V., additional, Strauss, B.H., additional, Bertrand, O., additional, and Barbato, E., additional
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- 2024
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4. Predictors Of Percutaneous Coronary Intervention Derived From Coronary Ct Angiography In Patients With Chronic Coronary Syndromes
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Belmonte, M., primary, Paolisso, P., additional, Gallinoro, E., additional, Bertolone, D., additional, Leone, A., additional, Sonck, J., additional, Vanderheyden, M., additional, Collet, C., additional, De Bruyne, B., additional, Andreini, D., additional, Penicka, M., additional, and Barbato, E., additional
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- 2024
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5. Gender-related differences in absolute coronary flow and microvascular resistance in patients with angina and non-obstructed coronary arteries (ANOCA)
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Belmonte, M, primary, Gallinoro, E, additional, Bertolone, D, additional, Paolisso, P, additional, Viscusi, M M, additional, Storozhenko, T, additional, Sakai, K, additional, Botti, G, additional, Barbato, E, additional, Vanderheyden, M M, additional, Collet, C, additional, and De Bruyne, B, additional
- Published
- 2023
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6. Poor prognosis of total culprit artery occlusion in patients presenting with NSTEMI
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Herman, R, primary, Smith, S W, additional, Meyers, H P, additional, Bertolone, D T, additional, Leone, A, additional, Bermpeis, K, additional, Viscusi, M, additional, Martonak, M, additional, Bahyl, J, additional, Demolder, A, additional, Perl, L, additional, Wojakowski, W, additional, Bartunek, J, additional, and Barbato, E, additional
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- 2023
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7. Endotypes of coronary microvascular dysfunction in patients with and without Diabetes Mellitus
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Gallinoro, E, primary, Paolisso, P, additional, Bertolone, D T, additional, Belmonte, M, additional, Esposito, G, additional, Munhoz, D, additional, Sakai, K, additional, Bermpeis, K, additional, Ohashi, H, additional, Storozhenko, T, additional, Seki, R, additional, Sonck, J, additional, Collet, C, additional, De Bruyne, B, additional, and Barbato, E, additional
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- 2023
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8. Impact of SGLT2-inhibitors on contrast-induced acute kidney injury in diabetic patients with acute myocardial infarction: data from SGLT2-I AMI PROTECT Registry
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Paolisso, P, primary, Bergamaschi, L, additional, Cesaro, A, additional, Gallinoro, E, additional, Gragnano, F, additional, Sardu, C, additional, Mileva, N, additional, Foa', A, additional, Esposito, G, additional, Oreglia, J A, additional, Casella, G, additional, Calabro', P, additional, Barbato, E, additional, Marfella, R, additional, and Pizzi, C, additional
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- 2023
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9. ECG-based deep learning for detecting epicardial coronary occlusion in acute myocardial infarction
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Herman, R, primary, Meyers, H P, additional, Smith, S W, additional, Demolder, A, additional, Bertolone, D T, additional, Leone, A, additional, Bermpeis, K, additional, Viscusi, M M, additional, Boza, V, additional, Kresnakova, V, additional, Martonak, M, additional, Perl, L, additional, Hatala, R, additional, Bartunek, J, additional, and Barbato, E, additional
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- 2023
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10. Cardiovascular risk and the COVID-19 pandemic: a retrospective observational study in a population of healthcare professionals
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Solfanelli, G, primary, Tropea, A, additional, Giaccio, D, additional, Bucicovschi, V, additional, Gallo, G, additional, Tocci, G, additional, Musumeci, M B, additional, Marcellini, L, additional, Barbato, E, additional, Volpe, M, additional, and Battistoni, A, additional
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- 2023
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11. Comparison of non-invasive and invasive cardiac damage staging in patients with clinically significant aortic stenosis
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Belmonte, M, primary, Paolisso, P, additional, Bertolone, D, additional, Viscusi, M M, additional, Gallinoro, E, additional, Esposito, G, additional, Addeo, L, additional, Shumkova, M, additional, De Oliveira, E, additional, Botti, G, additional, De Bruyne, B, additional, Barbato, E, additional, Bartunek, J, additional, Penicka, M, additional, and Vanderheyden, M, additional
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- 2023
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12. Are intraoral radiographs reliable in determining peri-implant marginal bone level changes? The correlation between open surgical measurements and peri-apical radiographs
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Cassetta, M., Di Giorgio, R., and Barbato, E.
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- 2018
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13. The year in cardiovascular medicine 2022: the top 10 papers in interventional cardiology
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Barbato, E., primary, McEntegart, M., additional, and Gori, T., additional
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- 2023
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14. Predictors Of Percutaneous Coronary Intervention Derived From Coronary Ct Angiography In Patients With Chronic Coronary Syndromes
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Belmonte, M., primary, Paolisso, P., additional, Gallinoro, E., additional, Bertolone, D., additional, Caglioni, S., additional, Leone, A., additional, De Colle, C., additional, Bermpeis, K., additional, Storozhenko, T., additional, Mileva, N., additional, Sonck, J., additional, Wyffels, E., additional, Venderheyden, M., additional, Collet, C., additional, De Bruyne, B., additional, Andreini, D., additional, Penicka, M., additional, and Barbato, E., additional
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- 2023
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15. Does percutaneous coronary stent implantation increase platelet reactivity?
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Janssen, P.W.A., Mol, E.A., Geene, S.M.C., Barbato, E., and ten Berg, J.M.
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- 2017
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16. RETRACTED ARTICLE: Epidemiological characteristic of Orofacial clefts and its associated congenital anomalies: retrospective study
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Impellizzeri, A., Giannantoni, I., Polimeni, A., Barbato, E., and Galluccio, G.
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- 2019
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17. Cardiovascular risk and the COVID-19 pandemic: a retrospective observational study in a population of healthcare professionals
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Solfanelli, G., primary, Giaccio, D., additional, Tropea, A., additional, Bucicovschi, V., additional, Gallo, G., additional, Tocci, G., additional, Musumeci, B., additional, Marcellini, L., additional, Barbato, E., additional, Volpe, M., additional, and Battistoni, A., additional
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- 2023
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18. ′Study of the maxillary yaw on cone beam computed tomography: A preliminary report and comparison between two different dento‐skeletal malocclusions′
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Vernucci, R. A., primary, Da Mommio, L., additional, Vellone, V., additional, De Stefano, A., additional, Barbato, E., additional, Di Giorgio, R., additional, and Galluccio, G., additional
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- 2023
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19. Periprocedural continuation versus interruption of oral anticoagulant drugs during transcatheter aortic valve implantation: rationale and design of the POPular PAUSE TAVI trial.
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Ginkel, D.J. van, Bor, W.L., Dubois, C.L., Aarts, H.M., Rooijakkers, M.J.P., Bergeijk, K.H. van, Rosseel, L., Veenstra, L., Backer, O. De, Mieghem, N.M. van, Kley, F. van der, Wilgenhof, A., Leonora, R., Halim, J., Schotborgh, C.E., Barbato, E., Heyden, J.A.S. Van der, Frambach, P., Ferdinande, B., Mylotte, D., Fabris, E., Rensing, B.J., Timmers, L., Swaans, M.J., Brouwer, Jorn, Nijenhuis, V.J., Peper, J., Vriesendorp, P.A., Laat, B. de, Ninivaggi, M., Stragier, H., Voskuil, M., IJsselmuiden, A.J.J., Hermanides, R.S., Agostoni, P., Hof, A.W. van 't, Wykrzykowska, J.J., Royen, N. van, Delewi, R., Berg, J.M. ten, Ginkel, D.J. van, Bor, W.L., Dubois, C.L., Aarts, H.M., Rooijakkers, M.J.P., Bergeijk, K.H. van, Rosseel, L., Veenstra, L., Backer, O. De, Mieghem, N.M. van, Kley, F. van der, Wilgenhof, A., Leonora, R., Halim, J., Schotborgh, C.E., Barbato, E., Heyden, J.A.S. Van der, Frambach, P., Ferdinande, B., Mylotte, D., Fabris, E., Rensing, B.J., Timmers, L., Swaans, M.J., Brouwer, Jorn, Nijenhuis, V.J., Peper, J., Vriesendorp, P.A., Laat, B. de, Ninivaggi, M., Stragier, H., Voskuil, M., IJsselmuiden, A.J.J., Hermanides, R.S., Agostoni, P., Hof, A.W. van 't, Wykrzykowska, J.J., Royen, N. van, Delewi, R., and Berg, J.M. ten
- Abstract
Item does not contain fulltext, About one-third of patients undergoing transcatheter aortic valve implantation (TAVI) use oral anticoagulants (OAC), mainly due to atrial fibrillation. General guidelines advise interrupting OAC in patients with a high risk of bleeding undergoing interventions. However, preliminary observational data suggest that the continuation of OAC during TAVI is safe and may reduce the risk of periprocedural thromboembolic events. The Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI) is a multicentre, randomised clinical trial with open-label treatment and blinded endpoint assessment. Patients are randomised 1:1 to periprocedural continuation versus interruption of OAC and are stratified for vitamin K antagonist or direct oral anticoagulant use. The primary endpoint is a composite of cardiovascular mortality, all stroke, myocardial infarction, major vascular complications and type 2-4 bleeding within 30 days after TAVI, according to the Valve Academic Research Consortium-3 criteria. Secondary endpoints include separate individual and composite outcomes, quality of life and cost-effectiveness. Since continuation of OAC is associated with the ancillary benefit that it simplifies periprocedural management, the primary outcome is first analysed for non-inferiority; if non-inferiority is proven, superiority will be tested. Recruitment started in November 2020, and the trial will continue until a total of 858 patients have been included and followed for 90 days. In summary, POPular PAUSE TAVI is the first randomised clinical trial to assess the safety and efficacy of periprocedural continuation versus interruption of OAC in patients undergoing TAVI.
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- 2023
20. Minimally invasive corticotomy in orthodontics using a three-dimensional printed CAD/CAM surgical guide
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Cassetta, M., Giansanti, M., Di Mambro, A., Calasso, S., and Barbato, E.
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- 2016
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21. Saline-induced coronary hyperemia with continuous intracoronary thermodilution is mediated by intravascular hemolysis
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Bertolone, D, primary, Gallinoro, E, additional, Candreva, A, additional, Fernandez Peregrina, E, additional, Bailleul, E, additional, Meeus, P, additional, Sonck, J, additional, Bermpeis, K, additional, Esposito, G, additional, Paolisso, P, additional, Heggermont, W, additional, Adjedj, J, additional, Barbato, E, additional, Collet, C, additional, and De Bruyne, B, additional
- Published
- 2022
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22. Repeatability of bolus and continuous thermodilution for assessing coronary microvasculatory function
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Gallinoro, E, primary, Fernandez-Peregrina, E, additional, Bertolone, D T, additional, Paolisso, P, additional, Bermpeis, K, additional, Esposito, G, additional, Belmonte, M, additional, Candreva, A, additional, Mileva, N, additional, Munhoz, D, additional, Sonck, J, additional, Barbato, E, additional, Collet, C, additional, and De Bruyne, B, additional
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- 2022
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23. Impact of aortic regurgitation on long-term outcomes in heart failure with preserved ejection fraction
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De Colle, C, primary, Paolisso, P, additional, Gallinoro, E, additional, Bertolone, D T, additional, Mileva, N, additional, Fabbricatore, D, additional, Valeriano, C, additional, Mancusi, C, additional, Collet, C, additional, Vanderheyden, M, additional, De Luca, N, additional, Van Camp, G, additional, Barbato, E, additional, Bartunek, J, additional, and Penicka, M, additional
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- 2022
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24. Diagnostic and prognostic role of cardiac magnetic resonance in patients with MINOCA
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Mileva, N, primary, Paolisso, P, additional, Gallinoro, E, additional, Bergamaschi, L, additional, Pizzi, C, additional, Barbato, E, additional, Penicka, M, additional, Andreini, D, additional, and Vassilev, D I, additional
- Published
- 2022
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25. Assessment of absolute coronary flow and microvascular resistance reserve in patients with severe aortic stenosis
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Gallinoro, E, primary, Paolisso, P, additional, Vanderheyden, M, additional, Esposito, G, additional, Bertolone, D T, additional, Mileva, N, additional, Bermpeis, K, additional, Belmonte, M, additional, De Colle, C, additional, Candreva, A, additional, Penicka, M, additional, Collet, C, additional, Sonck, J, additional, De Bruyne, B, additional, and Barbato, E, additional
- Published
- 2022
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26. Microvascular dysfunction in patients with diabetes mellitus: assessment of absolute coronary flow and microvascular resistance reserve
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Paolisso, P, primary, Gallinoro, E, additional, Belmonte, M, additional, Bertolone, D T, additional, Bermpeis, K, additional, Esposito, G, additional, Seki, R, additional, Fabbricatore, D, additional, Bartunek, J, additional, Vanderheyden, M, additional, Wyffels, E, additional, Sonck, J, additional, Collet, C, additional, De Bruyne, B, additional, and Barbato, E, additional
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- 2022
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27. Prevalence of atrial fibrillation and feasibility of pulmonary vein isolation after patent foramen ovale closure
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Fabbricatore, D, primary, Paolisso, P P, additional, Gallinoro, E G, additional, De Colle, C D C, additional, Valeriano, C V, additional, De Schouwer, K D S, additional, Geelen, P G, additional, Barbato, E B, additional, and De Potter, T D P, additional
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- 2022
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28. 581 Effects of cystic fibrosis transmembrane conductance regulator genotype on circadian system function
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Barbato, E., primary, Kelley, T., additional, and Darrah, R., additional
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- 2022
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29. Infarct size, inflammatory burden and admission hyperglycemia in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: a multicenter international registry
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Sansonetti, A, primary, Paolisso, P, additional, Bergamaschi, L, additional, Santulli, G, additional, Gallinoro, E, additional, Cesaro, A, additional, Gragnano, F, additional, Sardu, C, additional, Mileva, N, additional, Mauro, C, additional, Vassilev, D, additional, Marfella, R, additional, Calabro', P, additional, Barbato, E, additional, and Pizzi, C, additional
- Published
- 2022
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30. Percutaneous revascularization strategies in small-vessel disease
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Puymirat, E. and Barbato, E.
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- 2014
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31. How does an error in positioning the template affect the accuracy of implants inserted using a single fixed mucosa-supported stereolithographic surgical guide?
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Cassetta, M., Di Mambro, A., Giansanti, M., Stefanelli, L.V., and Barbato, E.
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- 2014
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32. Williams Syndrome: Oral Findings and Orthodontic Management of a Rare Disease
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Putrino, A., Altieri, F., Giovannoni, D., Di Giorgio, R., Barbato, E., Galluccio, G., and Cassetta, M.
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medicine.medical_specialty ,business.industry ,Williams syndrome ,dento-skeletal anomalies ,orthodontics, genetics ,medicine.disease ,Dermatology ,Medicine ,genetics ,orthodontics ,business ,General Dentistry ,Rare disease - Published
- 2021
33. Correlation between generalised joint hypermobility and temporomandibular joint disc displacement in adolescent patients: Magnetic Resonance Imaging study
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Boboc, A M, De Stefano, A, Impellizzeri, A, Barbato, E, and Galluccio, G
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Joint Instability ,joint laxity ,Adolescent ,Temporomandibular Joint ,Temporomandibular Joint Disc ,temporomandibular disorders ,Humans ,joint instability ,magnetic resonance imaging ,temporomandibular joint disc ,temporomandibular joint disorders ,Temporomandibular Joint Disorders ,Magnetic Resonance Imaging - Abstract
Temporomandibular disorders (TMD), in particular disc displacement, are recognised to have a multifactorial aetiology. Ligamentous laxity has been suggested as a potential risk factor for TMD. Ligamentous laxity can lead to generalised joint hypermobility (GJH) involving multiple joints, including the temporomandibular joint (TMJ). The aim of this work is to evaluate the correlation between GJH and disc displacement (DD) assessed on magnetic resonance images (MRI) of the TMJ in adolescent patients.The study was included 40 adolescent patients (10-16 years), divided into two groups, a Study Group (SG), composed of 20 subjects with GJH, and a Control Group (CG), composed of 20 subjects without GJH. The GJH was assessed by the Beighton test with a threshold value of ≥ 4. The severity of the TMD was determined using the Fonseca Questionnaire and a clinical evaluation of the type of TMD. The condylar-discal relationship and the condylar mobility of the TMJ were evaluated by MRI. Pearson's χ2 Test was performed for the analysis of the statistical correlation.This study suggests that adolescents with GJH have a greater risk of developing TMJ disc displacement, especially disc displacement without reduction.
- Published
- 2022
34. 437 Accuracy Of The FFRCTPlanner In Coronary Calcific Lesions
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Belmonte, M., primary, Collet, C., additional, Nørgaard, B., additional, Otake, H., additional, Koo, B., additional, Andreini, D., additional, Mizukami, T., additional, Updegrove, A., additional, Barbato, E., additional, De Bruyne, B., additional, Leipsic, J., additional, Taylor, C., additional, Maeng, M., additional, and Sonck, J., additional
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- 2022
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35. European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1—epidemiology, pathophysiology, and diagnosis
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Baigent, C., Windecker, S., Andreini, D., Arbelo, E., Barbato, E., Bartorelli, A.L., Baumbach, A., Behr, E.R., Berti, S., Bueno, H., Capodanno, D., Cappato, R., Chieffo, A., Collet, J.P., Cuisset, T., Simone, G. de, Delgado, V., Dendale, P., Dudek, D., Edvardsen, T., Elvan, A., Gonzalez-Juanatey, J.R., Gori, M., Grobbee, D., Guzik, T.J., Halvorsen, S., Haude, M., Heidbuchel, H., Hindricks, G., Ibanez, B., Karam, N., Katus, H., Klok, F.A., Konstantinides, S.V., Landmesser, U., Leclercq, C., Leonardi, S., Lettino, M., Marenzi, G., Mauri, J., Metra, M., Morici, N., Mueller, C., Petronio, A.S., Polovina, M.M., Potpara, T., Praz, F., Prendergast, B., Prescott, E., Price, S., Pruszczyk, P., Rodriguez-Leor, O., Roffi, M., Romaguera, R., Rosenkranz, S., Sarkozy, A., Scherrenberg, M., Seferovic, P., Senni, M., Spera, F.R., Stefanini, G., Thiele, H., Tomasoni, D., Torracca, L., Touyz, R.M., Wilde, A.A., Williams, B., Task Force Management Covid-19 Eur, Nuffield Department of Population Health [Oxford], University of Oxford, Bern University Hospital [Berne] (Inselspital), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Glasgow, Amsterdam UMC - Amsterdam University Medical Center, University College of London [London] (UCL), Baigent, C, Cardiology, Task Force for the management of COVID-19 of the European Society of, Cardiology, ACS - Heart failure & arrhythmias, Task Force Management Covid-19 Eur, University of Oxford [Oxford], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), delgado, victoria/0000-0002-9841-2737, BUENO, HECTOR/0000-0003-0277-7596, Karam, Nicole/0000-0002-3861-6914, Baigent, Colin/0000-0003-4856-7420, Behr, Elijah/0000-0002-8731-2853, Williams, Bryan/0000-0002-8094-1841, Rodriguez-Leor, Oriol/0000-0003-2657-5657, BUENO, HECTOR/0000-0003-0277-7596, Rodriguez-Leor, Oriol/0000-0003-2657-5657, Williams, Bryan/0000-0002-8094-1841, Karam, and Nicole/0000-0002-3861-6914
- Subjects
ACE2 ,Arrhythmias ,Biomarkers ,Cardiogenic shock ,COVID-19 ,Myocardial ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Physiology ,Myocardial injury ,Myocarditis ,Non-invasive imaging ,Humans ,Pandemics ,Prospective Studies ,Cardiology ,Cardiovascular Diseases ,Settore MED/11 - Malattie dell'Apparato Cardiovascolare ,Disease ,Special Article ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Physiology (medical) ,injury ,Pandemic ,Epidemiology ,Medicine ,AcademicSubjects/MED00200 ,Intensive care medicine ,business.industry ,Pathophysiology ,Human medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims Since its emergence in early 2020, the novel severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019 (COVID-19) has reached pandemic levels, and there have been repeated outbreaks across the globe. The aim of this two-part series is to provide practical knowledge and guidance to aid clinicians in the diagnosis and management of cardiovascular disease (CVD) in association with COVID-19. Methods and results A narrative literature review of the available evidence has been performed, and the resulting information has been organized into two parts. The first, reported here, focuses on the epidemiology, pathophysiology, and diagnosis of cardiovascular (CV) conditions that may be manifest in patients with COVID-19. The second part, which will follow in a later edition of the journal, addresses the topics of care pathways, treatment, and follow-up of CV conditions in patients with COVID-19. Conclusion This comprehensive review is not a formal guideline but rather a document that provides a summary of current knowledge and guidance to practicing clinicians managing patients with CVD and COVID-19. The recommendations are mainly the result of observations and personal experience from healthcare providers. Therefore, the information provided here may be subject to change with increasing knowledge, evidence from prospective studies, and changes in the pandemic. Likewise, the guidance provided in the document should not interfere with recommendations provided by local and national healthcare authorities., Graphical Abstract Graphical Abstract
- Published
- 2022
36. Functional Patterns of Coronary Disease: Diffuse, Focal, and Serial Lesions
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Scarsini, R., Fezzi, S., Leone, Antonio Maria, De Maria, Giovanni Luigi, Pighi, M., Marcoli, M., Tavella, D., Pesarini, G., Banning, A. P., Barbato, E., Wijns, W., Ribichini, F. L., Leone A. M. (ORCID:0000-0002-1276-9883), De Maria G. L. (ORCID:0000-0003-3572-1855), Scarsini, R., Fezzi, S., Leone, Antonio Maria, De Maria, Giovanni Luigi, Pighi, M., Marcoli, M., Tavella, D., Pesarini, G., Banning, A. P., Barbato, E., Wijns, W., Ribichini, F. L., Leone A. M. (ORCID:0000-0002-1276-9883), and De Maria G. L. (ORCID:0000-0003-3572-1855)
- Abstract
The physiological assessment of coronary lesions is influenced by the pattern and distribution of coronary artery disease (CAD), including focal lesions, serial lesions, diffuse disease, and mixed patterns. These various patterns of CAD impact the accuracy of pressure wire and angiography-derived physiology indexes, and diffuse disease in particular is an important determinant of the anticipated outcome of percutaneous coronary intervention. Therefore, identification of the physiological pattern of disease provides relevant information for the management of CAD and percutaneous coronary intervention procedural planning. At present, the classification of physiological patterns and its implications for the tailored management of a patient with CAD are poorly defined. This state-of-the-art review provides an overview of the available evidence on functional patterns of CAD with a special focus on their diagnostic and therapeutic implications. It also aims to provide clear definitions of physiological patterns of CAD based on the available evidence and expert opinion. A practical algorithm is provided to optimize the use of pressure wire and angiography-derived indexes of coronary physiology in the settings of focal, serial, and diffuse lesions, with the addition of intracoronary imaging in selected cases.
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- 2022
37. Periprocedural variations of platelet reactivity during elective percutaneous coronary intervention
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MANGIACAPRA, F., BARTUNEK, J., BIJNENS, N., PEACE, A.J., DIERICKX, K., BAILLEUL, E., DI SERAFINO, L., PYXARAS, S.A., FRAEYMAN, A., MEEUS, P., RUTTEN, M., DE BRUYNE, B., WIJNS, W., VAN de VOSSE, F., and BARBATO, E.
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- 2012
- Full Text
- View/download PDF
38. Severe side effects on all the anterior lower teeth of a bonded retainer: a clinical case : Gravi effetti collaterali sui denti anteriori inferiori di un retainer fisso: un caso clinico
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Grenga, C., Guarnieri, R., Galluccio, G., Grenga, V., and Barbato, E.
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fixed retainers ,side effects ,case reports ,orthodontic retreatment ,orthodontics - Published
- 2022
39. Invasive Coronary Physiology After Stent Implantation: Another Step Toward Precision Medicine
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Biscaglia S., Uretsky B., Barbato E., Collet C., Onuma Y., Jeremias A., Tebaldi M., Hakeem A., Kogame N., Sonck J., Escaned J., Serruys P. W., Stone G. W., Campo G., Biscaglia, S., Uretsky, B., Barbato, E., Collet, C., Onuma, Y., Jeremias, A., Tebaldi, M., Hakeem, A., Kogame, N., Sonck, J., Escaned, J., Serruys, P. W., Stone, G. W., and Campo, G.
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coronary physiology ,quantitative flow ratio ,precision medicine ,percutaneous coronary intervention ,Coronary Artery Disease ,Coronary Angiography ,instantaneous wave-free ratio ,NO ,Fractional Flow Reserve, Myocardial ,Treatment Outcome ,Predictive Value of Tests ,fractional flow reserve ,outcome ,Humans ,Stents - Abstract
Intracoronary physiology is routinely used in setting the indication for percutaneous coronary intervention (PCI) but seldom in assessing procedural results. This attitude is increasingly challenged by accumulated evidence demonstrating the value of post-PCI functional assessment in predicting long-term patient outcomes. Besides fractional flow reserve, a number of new indexes recently incorporated to clinical practice, including nonhyperemic pressure and functional angiographic indexes, provide new opportunities for the physiological assessment of PCI results. Largely, the benefit of these tools is derived from longitudinal analysis of the treated vessel, which allows precise identification of the vessel segment accounting for a suboptimal functional result and enabling operators to perform accurate PCI optimization. In this document the authors review available evidence supporting why physiological assessment should be extended to immediate post-PCI with the aim of improving patient outcomes. A step-by-step guide on how available physiological tools can be used for such purpose is provided.
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- 2021
40. Performance of non-invasive myocardial work to predict the first hospitalization for de novo heart failure with preserved ejection fraction (HFpEF)
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Paolisso, P, primary, Gallinoro, E, additional, Mileva, N, additional, Moya, A, additional, Fabbricatore, D, additional, Esposito, G, additional, De Colle, C, additional, Spapen, J, additional, Heggermont, W, additional, Collet, C, additional, Van Camp, G, additional, Vanderheyden, M, additional, Barbato, E, additional, Bartunek, J, additional, and Penicka, M, additional
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- 2022
- Full Text
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41. European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1-epidemiology, pathophysiology, and diagnosis The Task Force for the management of COVID-19 of the European Society of Cardiology
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Baigent, C., Windecker, S., Andreini, D., Arbelo, E., Barbato, E., Bartorelli, A.L., Baumbach, A., Behr, E.R., Berti, S., Bueno, H., Capodanno, D., Cappato, R., Chieffo, A., Collet, J.P., Cuisset, T., Simone, G. de, Delgado, V., Dendale, P., Dudek, D., Edvardsen, T., Elvan, A., Gonzalez-Juanatey, J.R., Gori, M., Grobbee, D., Guzik, T.J., Halvorsen, S., Haude, M., Heidbuchel, H., Hindricks, G., Ibanez, B., Karam, N., Katus, H., Klok, F.A., Konstantinides, S.V., Landmesser, U., Leclercq, C., Leonardi, S., Lettino, M., Marenzi, G., Mauri, J., Metra, M., Morici, N., Mueller, C., Petronio, A.S., Polovina, M.M., Potpara, T., Praz, F., Prendergast, B., Prescott, E., Price, S., Pruszczyk, P., Rodriguez-Leor, O., Roffi, M., Romaguera, R., Rosenkranz, S., Sarkozy, A., Scherrenberg, M., Seferovic, P., Senni, M., Spera, F.R., Stefanini, G., Thiele, H., Tomasoni, D., Torracca, L., Touyz, R.M., Wilde, A.A., Williams, B., and European Soc Cardiology
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Myocarditis ,Myocardial injury ,Non-invasive imaging ,ACE2 ,COVID-19 ,Arrhythmias ,Cardiogenic shock ,Biomarkers - Abstract
Aims Since its emergence in early 2020, the novel severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019 (COVID-19) has reached pandemic levels, and there have been repeated outbreaks across the globe. The aim of this two-part series is to provide practical knowledge and guidance to aid clinicians in the diagnosis and management of cardiovascular disease (CVD) in association with COVID-19.Methods and results A narrative literature review of the available evidence has been performed, and the resulting information has been organized into two parts. The first, reported here, focuses on the epidemiology, pathophysiology, and diagnosis of cardiovascular (CV) conditions that may be manifest in patients with COVID-19. The second part, which will follow in a later edition of the journal, addresses the topics of care pathways, treatment, and follow-up of CV conditions in patients with COVID-19.Conclusion This comprehensive review is not a formal guideline but rather a document that provides a summary of current knowledge and guidance to practicing clinicians managing patients with CVD and COVID-19. The recommendations are mainly the result of observations and personal experience from healthcare providers. Therefore, the information provided here may be subject to change with increasing knowledge, evidence from prospective studies, and changes in the pandemic. Likewise, the guidance provided in the document should not interfere with recommendations provided by local and national healthcare authorities.[GRAPHICS].
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- 2021
42. Wytyczne ESC/ESH dotyczace postȩpowania w nadciśnieniu tȩtniczym (2018): Grupa Robocza Europejskiego Towarzystwa Kardiologicznego (ESC) i Europejskiego Towarzystwa Nadciśnienia Tȩtniczego (ESH) do spraw postȩpowania w nadciśnieniu tȩtniczym
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Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Windecker, S, Agewall, S, Barbato, E, Bueno, H, Collet, J, Coman, I, Dean, V, Delgado, V, Fitzsimons, D, Gaemperli, O, Hindricks, G, Iung, B, Juni, P, Katus, H, Knuuti, J, Lancellotti, P, Leclercq, C, Mcdonagh, T, Piepoli, M, Ponikowski, P, Richter, D, Roffi, M, Simpson, I, Sousa-Uva, M, Zamorano, J, Lurbe, E, Bochud, M, Jelakovic, B, Januszewicz, A, Polonia, J, Van De Borne, P, Borghi, C, Parati, G, Manolis, A, Lovic, D, Benkhedda, S, Zelveian, P, Siostrzonek, P, Najafov, R, Pavlova, O, De Pauw, M, Dizdarevic-Hudic, L, Raev, D, Karpettas, N, Olsen, M, Shaker, A, Viigimaa, M, Baranova, E, Metsarinne, K, Halimi, J, Pagava, Z, Thomopoulos, C, Bertomeu-Martinez, V, Wittekoek, J, Andersen, K, Shechter, M, Romanova, T, Bajraktari, G, Saade, G, Sakalyte, G, Noppe, S, Trusinskis, K, Vavlukis, M, Demarco, D, Caraus, A, Schunkert, H, Aksnes, T, Jankowski, P, Linhart, A, Vinereanu, D, Foscoli, M, Dikic, A, Filipova, S, Fras, Z, Burkard, T, Carlberg, B, Sdiri, W, Aydogdu, S, Sirenko, Y, Pall, D, Brady, A, Mercuro, G, Weber, T, Lazareva, I, De Backer, T, Sokolovic, S, Chazova, I, Porsti, I, Denolle, T, Stergiou, G, Segura, J, Miglinas, M, Kramer, B, Gerdts, E, Tykarski, A, De Carvalho Rodrigues, M, Widimsky, J, Dorobantu, M, Brguljan, J, Pechere-Bertschi, A, Gottsater, A, Erdine, S, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., Windecker S., Agewall S., Barbato E., Bueno H., Collet J. -P., Coman I. M., Dean V., Delgado V., Fitzsimons D., Gaemperli O., Hindricks G., Iung B., Juni P., Katus H. A., Knuuti J., Lancellotti P., Leclercq C., McDonagh T. A., Piepoli M. F., Ponikowski P., Richter D. J., Roffi M., Simpson I. A., Sousa-Uva M., Zamorano J. L., Lurbe E., Bochud M., Jelakovic B., Januszewicz A., Polonia J., Van De Borne P., Borghi C., Parati G., Manolis A., Lovic D., Benkhedda S., Zelveian P., Siostrzonek P., Najafov R., Pavlova O., De Pauw M., Dizdarevic-Hudic L., Raev D., Karpettas N., Olsen M. H., Shaker A. F., Viigimaa M., Baranova E. I., Metsarinne K., Halimi J. -M., Pagava Z., Thomopoulos C., Bertomeu-Martinez V., Wittekoek J., Andersen K., Shechter M., Romanova T., Bajraktari G., Saade G. A., Sakalyte G., Noppe S., Trusinskis K., Vavlukis M., DeMarco D. C., Caraus A., Schunkert H., Aksnes T. A., Jankowski P., Linhart A., Vinereanu D., Foscoli M., Dikic A. D., Filipova S., Fras Z., Burkard T., Carlberg B., Sdiri W., Aydogdu S., Sirenko Y., Pall D., Brady A., Mercuro G., Weber T., Lazareva I., De Backer T., Sokolovic S., Chazova I., Porsti I., Denolle T., Stergiou G. S., Segura J., Miglinas M., Kramer B. K., Gerdts E., Tykarski A., De Carvalho Rodrigues M., Widimsky J., Dorobantu M., Brguljan J., Pechere-Bertschi A., Gottsater A., Erdine S., Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Windecker, S, Agewall, S, Barbato, E, Bueno, H, Collet, J, Coman, I, Dean, V, Delgado, V, Fitzsimons, D, Gaemperli, O, Hindricks, G, Iung, B, Juni, P, Katus, H, Knuuti, J, Lancellotti, P, Leclercq, C, Mcdonagh, T, Piepoli, M, Ponikowski, P, Richter, D, Roffi, M, Simpson, I, Sousa-Uva, M, Zamorano, J, Lurbe, E, Bochud, M, Jelakovic, B, Januszewicz, A, Polonia, J, Van De Borne, P, Borghi, C, Parati, G, Manolis, A, Lovic, D, Benkhedda, S, Zelveian, P, Siostrzonek, P, Najafov, R, Pavlova, O, De Pauw, M, Dizdarevic-Hudic, L, Raev, D, Karpettas, N, Olsen, M, Shaker, A, Viigimaa, M, Baranova, E, Metsarinne, K, Halimi, J, Pagava, Z, Thomopoulos, C, Bertomeu-Martinez, V, Wittekoek, J, Andersen, K, Shechter, M, Romanova, T, Bajraktari, G, Saade, G, Sakalyte, G, Noppe, S, Trusinskis, K, Vavlukis, M, Demarco, D, Caraus, A, Schunkert, H, Aksnes, T, Jankowski, P, Linhart, A, Vinereanu, D, Foscoli, M, Dikic, A, Filipova, S, Fras, Z, Burkard, T, Carlberg, B, Sdiri, W, Aydogdu, S, Sirenko, Y, Pall, D, Brady, A, Mercuro, G, Weber, T, Lazareva, I, De Backer, T, Sokolovic, S, Chazova, I, Porsti, I, Denolle, T, Stergiou, G, Segura, J, Miglinas, M, Kramer, B, Gerdts, E, Tykarski, A, De Carvalho Rodrigues, M, Widimsky, J, Dorobantu, M, Brguljan, J, Pechere-Bertschi, A, Gottsater, A, Erdine, S, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., Windecker S., Agewall S., Barbato E., Bueno H., Collet J. -P., Coman I. M., Dean V., Delgado V., Fitzsimons D., Gaemperli O., Hindricks G., Iung B., Juni P., Katus H. A., Knuuti J., Lancellotti P., Leclercq C., McDonagh T. A., Piepoli M. F., Ponikowski P., Richter D. J., Roffi M., Simpson I. A., Sousa-Uva M., Zamorano J. L., Lurbe E., Bochud M., Jelakovic B., Januszewicz A., Polonia J., Van De Borne P., Borghi C., Parati G., Manolis A., Lovic D., Benkhedda S., Zelveian P., Siostrzonek P., Najafov R., Pavlova O., De Pauw M., Dizdarevic-Hudic L., Raev D., Karpettas N., Olsen M. H., Shaker A. F., Viigimaa M., Baranova E. I., Metsarinne K., Halimi J. -M., Pagava Z., Thomopoulos C., Bertomeu-Martinez V., Wittekoek J., Andersen K., Shechter M., Romanova T., Bajraktari G., Saade G. A., Sakalyte G., Noppe S., Trusinskis K., Vavlukis M., DeMarco D. C., Caraus A., Schunkert H., Aksnes T. A., Jankowski P., Linhart A., Vinereanu D., Foscoli M., Dikic A. D., Filipova S., Fras Z., Burkard T., Carlberg B., Sdiri W., Aydogdu S., Sirenko Y., Pall D., Brady A., Mercuro G., Weber T., Lazareva I., De Backer T., Sokolovic S., Chazova I., Porsti I., Denolle T., Stergiou G. S., Segura J., Miglinas M., Kramer B. K., Gerdts E., Tykarski A., De Carvalho Rodrigues M., Widimsky J., Dorobantu M., Brguljan J., Pechere-Bertschi A., Gottsater A., and Erdine S.
- Published
- 2019
43. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
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Ray, K, Colhoun, H, Szarek, M, Baccara-Dinet, M, Bhatt, D, Bittner, V, Budaj, A, Diaz, R, Goodman, S, Hanotin, C, Harrington, R, Jukema, J, Loizeau, V, Lopes, R, Moryusef, A, Murin, J, Pordy, R, Ristic, A, Roe, M, Tunon, J, White, H, Zeiher, A, Schwartz, G, Steg, P, Tricoci, P, Mahaffey, K, Edelberg, J, Lecorps, G, Sasiela, W, Tamby, J, Aylward, P, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, N, Prieto, J, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Ostadal, P, Viigimaa, M, Nieminen, M, Chumburidze, V, Marx, N, Danchin, N, Liberopoulos, E, Montenegro Valdovinos, P, Tse, H, Kiss, R, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, H, Kim, S, Erglis, A, Laucevicius, A, Kedev, S, Yusoff, K, Ramos Lopez, G, Alings, M, Halvorsen, S, Correa Flores, R, Morais, J, Dorobantu, M, Karpov, Y, Chua, T, Fras, Z, Dalby, A, de Silva, H, Hagstrom, E, Landmesser, U, Chiang, C, Sritara, P, Guneri, S, Parkhomenko, A, Moriarty, P, Vogel, R, Chaitman, B, Kelsey, S, Olsson, A, Rouleau, J, Simoons, M, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, E, Alexander, J, Armaganijan, L, Bagai, A, Bahit, M, Brennan, J, Clifton, S, Devore, A, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Harrison, R, Hess, C, Hlatky, M, Jordan, J, Knowles, J, Kolls, B, Kong, D, Leonardi, S, Lillis, L, Maron, D, Marcus, J, Mathews, R, Mehta, R, Mentz, R, Moreira, H, Patel, C, Bernardez-Pereira, S, Perkins, L, Povsic, T, Puymirat, E, Schuyler Jones, W, Shah, B, Sherwood, M, Stringfellow, K, Sujjavanich, D, Toma, M, Trotter, C, Van Diepen, S, Wilson, M, Yan, A, Schiavi, L, Garrido, M, Alvarisqueta, A, Sassone, S, Bordonava, A, Alves De Lima, A, Schmidberg, J, Duronto, E, Caruso, O, Novaretto, L, Hominal, M, Montana, O, Caccavo, A, Gomez Vilamajo, O, Lorenzatti, A, Cartasegna, L, Paterlini, G, Mackinnon, I, Caime, G, Amuchastegui, M, Salomone, O, Codutti, O, Jure, H, Bono, J, Hrabar, A, Vallejos, J, Ahuad Guerrero, R, Novoa, F, Patocchi, C, Zaidman, C, Giuliano, M, Dran, R, Vico, M, Carnero, G, Guzman, P, Medrano Allende, J, Garcia Brasca, D, Bustamante Labarta, M, Nani, S, Blumberg, E, Colombo, H, Liberman, A, Fuentealba, V, Luciardi, H, Waisman, G, Berli, M, Garcia Duran, R, Cestari, H, Luquez, H, Giordano, J, Saavedra, S, Zapata, G, Costamagna, O, Llois, S, Waites, J, Collins, N, Soward, A, Hii, C, Shaw, J, Arstall, M, Horowitz, J, Ninio, D, Rogers, J, Colquhoun, D, Oqueli Flores, R, Roberts-Thomson, P, Raffel, O, Lehman, S, Aroney, C, Coverdale, S, Garrahy, P, Starmer, G, Sader, M, Carroll, P, Dick, R, Zweiker, R, Hoppe, U, Huber, K, Berger, R, Delle-Karth, G, Frey, B, Weidinger, F, Faes, D, Hermans, K, Pirenne, B, Leone, A, Hoffer, E, Vrolix, M, De Wolf, L, Wollaert, B, Castadot, M, Dujardin, K, Beauloye, C, Vervoort, G, Striekwold, H, Convens, C, Roosen, J, Barbato, E, Claeys, M, Cools, F, Terzic, I, Barakovic, F, Midzic, Z, Pojskic, B, Fazlibegovic, E, Kulic, M, Durak-Nalbantic, A, Vulic, D, Muslibegovic, A, Goronja, B, Reis, G, Sousa, L, Nicolau, J, Giorgeto, F, Silva, R, Nigro Maia, L, Rech, R, Rossi, P, Cerqueira, M, Duda, N, Kalil, R, Kormann, A, Abrantes, J, Pimentel Filho, P, Soggia, A, de Santos, M, Neuenschwander, F, Bodanese, L, Michalaros, Y, Eliaschewitz, F, Vidotti, M, Leaes, P, Botelho, R, Kaiser, S, Manenti, E, Precoma, D, Moura Jorge, J, de B Silva, P, Silveira, J, Saporito, W, Marin-Neto, J, Feitosa, G, Ritt, L, de Souza, J, Costa, F, Souza, W, Reis, H, Machado, L, Ayoub, J, Todorov, G, Nikolov, F, Velcheva, E, Tzekova, M, Benov, H, Petranov, S, Tumbev, H, Shehova-Yankova, N, Markov, D, Raev, D, Mollov, M, Kichukov, K, Ilieva-Pandeva, K, Ivanova, R, Gospodinov, M, Mincheva, V, Lazov, P, Dimov, B, Senaratne, M, Stone, J, Kornder, J, Pearce, S, Dion, D, Savard, D, Pesant, Y, Pandey, A, Robinson, S, Gosselin, G, Vizel, S, Hoag, G, Bourgeois, R, Morisset, A, Sabbah, E, Sussex, B, Kouz, S, Macdonald, P, Diaz, A, Michaud, N, Fell, D, Leung, R, Vuurmans, T, Lai, C, Nigro, F, Davies, R, Nogareda, G, 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S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. 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R., Troquay R. P., Viergever E. P., Al-Windy N. Y., Bartels G. L., Cornel J. H., Hermans W. R., Herrman J. P., Bos R. J., Groutars R. G., Van Der Zwaan C. C., Kaplan R., Lionarons R., Ronner E., Groenemeijer B. E., Bronzwaer P. N., Liem A. A., Rensing B. J., Bokern M. J., Nijmeijer R., Hersbach F. M., Willems F. F., Gosselink A. T., Rasoul S., Elliott J., Wilkins G., Fisher R., Scott D., Hart H., Stewart R., Harding S., Ternouth I., Fisher N., Wilson S., Aitken D., Anscombe R., Davidson L., Tomala T., Nygard O., Sparby J. A., Andersen K., Gullestad L., Jortveit J., Munk P. S., Singsaas E. G., Hurtig U., Calderon Ticona J. R., Durand Velasquez J. R., Negron Miguel S. A., Sanabria Perez E. S., Carrion Chambilla J. M., Chavez Ayala C. A., Castillo Leon R. P., Vargas Gonzales R. J., Hernandez Zuniga J. D., Camacho Cosavalente L. A., Bravo Mannucci J. E., Heredia Landeo J., Llerena Navarro N. C., Roldan Concha Y. M., Rodriguez Chavez V. E., Anchante Hernandez H. A., Zea Nunez C. A., Mogrovejo Ramos W., Ferrolino A., Sy R. A. G., Tirador L., Sy R. G., Matiga G., Coching R. M., Bernan A., Rogelio G., Morales D. D., Tan E., Sulit D. J., Wlodarczak A., Jaworska K., Skonieczny G., Pawlowicz L., Wojewoda P., Busz-Papiez B., Bednarski J., Goch A., Staneta P., Dulak E., Saminski K., Krasowski W., Sudnik W., Zurakowski A., Skorski M., Miklaszewicz B., Kubica J., Andrzej Lipko J., Kostarska-Srokosz E., Piepiorka M., Drzewiecka A., Stasiewski A., Blicharski T., Bystryk L., Szpajer M., Korol M., Czerski T., Mirek-Bryniarska E., Gniot J., Lubinski A., Gorny J., Franek E., Raczak G., Szwed H., Monteiro P., Mesquita Bastos J., Pereira H. H., Martins D., Seixo F., Mendonca C., Botelho A., Caetano F., Minescu B., Istratoaie O., Tesloianu D. N., Cristian G., Dumitrescu S., Podoleanu C. G., Constantinescu M. C., Bengus C. M., Militaru C., Rosu D., Parepa I. R., Matei A. V., Alexandru T. M., Malis M., Coman I., Stanescu-Cioranu R., Dimulescu D., Shvarts Y., Orlikova O., Kobalava Z., Barbarash O. L., Markov V., Lyamina N., Gordienko A., Zrazhevsky K., Vishnevsky A. Y., Gurevich V., Stryuk R., Lomakin N. V., Bokarev I., Khlevchuk T., Shalaev S., Khaisheva L., Chizhov P., Viktorova I., Osokina N., Shchekotov V., Akatova E., Chumakova G., Libov I., Voevoda M. I., Tretyakova T. V., Baranov E., Shustov S., Yakushin S., Gordeev I., Khasanov N., Reshetko O., Sotnikova T., Molchanova O., Nikolaev K., Gapon L., Baranova E., Shogenov Z., Kosmachova E., Povzun A., Egorova L., Tyrenko V. V., Ivanov I. G., Ilya M., Kanorsky S., Simic D., Ivanovic N., Davidovic G., Tasic N., Asanin M. R., Stojic S., Apostolovic S. R., Ilic S., Putnikovic Tosic B., Stankovic A., Arandjelovic A., Radovanovic S., Todic B., Balinovac J., Dincic D. V., Seferovic P., Karadzic A., Dodic S., Dimkovic S., Jakimov T., Poh K. -K., Ong H. Y., Tang I-Shing J., Micko K., Nociar J., Pella D., Fulop P., Hranai M., Palka J., Mazur J., Majercak I., Dzupina A., Fazekas F., Gonsorcik J., Bugan V., Selecky J., Kamensky G., Strbova J., Smik R., Dukat A., Zuran I., Poklukar J., Cernic Suligoj N., Cevc M., Cyster H. P., Ranjith N., Corbett C., Bayat J., Makotoko E. M., du Toit Theron H., Kapp I. E., de V Basson M. M., Lottering H., Van Aswegen D., Van Zyl L. J., Sebastian P. J., Pillay T., Saaiman J. A., Commerford P. J., Cassimjee S., Riaz G., Ebrahim I. O., Sarvan M., Mynhardt J. H., Reuter H., Moodley R., Vida M., Cequier Fillat A. R., Bodi Peris V., Fuentes Jimenez F., Marin F., Cruz Fernandez J. M., Hidalgo Urbano R. J., Gil-Extremera B., Toledo P., Worner Diz F., Garcia-Dorado D., Iniguez A., Gonzalez-Juanatey J. R., Fernandez Portales J., Civeira Murillo F., Matas Pericas L., Zamorano J. L., De Mora Martin M., Bruguera Cortada J., Alonso Martin J. J., Serrano Antolin J. M., De Berrazueta Fernandez J. R., Vazquez de Prada J. A., Diaz Fernandez J. F., Garcia Lledo J. A., Cosin Sales J., Botas Rodriguez J., Gusi Tragant G., Benedicto A., Gonzalez-Juanatey C., Camprubi Potau M., Plaza Perez I., De La Tassa C. M., Loma-Osorio Rincon P., Balaguer Recena J., Escudier J. M., Payeras A. C., Alonso Orcajo N., Valdivielso P., Constantine G., Haniffa R., Tissera N., Amarasekera S., Ponnamperuma C., Fernando N., Fernando K., Jayawardena J., Wijeyasingam S., Ranasinghe G., Ekanayaka R., Mendis S., Senaratne V., Mayurathan G., Sirisena T., Rajapaksha A., Herath J. I., Amarasena N., Berglund S., Rasmanis G., Vedin O., Witt N., Mourtzinis G., Nicol P., Hansen O., Romeo S., Agergaard Jensen S., Torstensson I., Ahremark U., Sundelin T., Moccetti T., Muller C., Mach F., Binde R., Tsai W. -C., Ueng K. -C., Lai W. -T., Liu M. -E., Hwang J. -J., Yin W. -H., Hsieh I. -C., Hsieh M. -J., Lin W. 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M., Subkovas E., Braganza D., Sarkar D., Storey R., Griffiths H., McClure S., Muthusamy R., Smith S., Kurian J., Levy T., Barr C., Kadr H., Gerber R., Simaitis A., Soran H., Mathur A., Brodison A., Ayaz M., Cheema M., Oliver R., Thackray S., Mudawi T., Rahman G., Sultan A., Sharman D., Sprigings D., Butler R., Wilkinson P., Lip G. Y., Halcox J., Gallagher S., Ossei-Gerning N., Vardi G., Baldari D., Brabham D., Treasure II C., Dahl C., Palmer B., Wiseman A., Puri S., Mohart A. E., Ince C., Flores E., Wright S., Cheng S. -C., Rosenberg M., Rogers W., Kosinski E., Forgosh L., Waltman J., Khan M., Shoukfeh M., Dagher G., Cambier P., Lieber I., Kumar P., East C., Krichmar P., Hasan M., White L., Knickelbine T., Haldis T., Gillespie E., Amidon T., Suh D., Arif I., Abdallah M., Akhter F., Carlson E., D'Urso M., El-Ahdab F., Nelson W., Moriarty K., Harris B., Cohen S., Carter L., Doty D., Sabatino K., Haddad T., Malik A., Rao S., Mulkay A., Jovin I., Klancke K., Malhotra V., Devarapalli S. K., Koren M., Chandna H., Dodds III G., Goraya T., Bengston J., Janik M., Moran J., Sumner A., Kobayashi J., Davis W., Yazdani S., Pasquini J., Thakkar M., Vedere A., Leimbach W., Rider J., Fenton S., Singh N., Shah A. V., Janosik D., Pepine C., Berman B., Gelormini J., Daniels C., Richard K., Keating F., Kondo N. I., Shetty S., Levite H., Waider W., Takata T., Abu-Fadel M., Shah V., Aggarwal R., Izzo M., Kumar A., Hattler B., Do R., Link C., Bortnick A., Kinzfogl III G., Ghitis A., Larry J., Teufel E., Kuhlman P., Mclaurin B., Zhang W., Thew S., Abbas J., White M., Islam O., Subherwal S., Ranadive N., Vakili B., Gring C., Henderson D., Schuchard T., Farhat N., Kline G., Mahal S., Whitaker J., Speirs S., Andersen R., Daboul N., Horwitz P., Zahr F., Ponce G., Jafar Z., Mcgarvey J., Panchal V., Voyce S., Blok T., Sheldon W., Azizad M. M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. 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F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. A., and McClanahan M. A.
- Abstract
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring
- Published
- 2019
44. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
- Author
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Knuuti, Juhani, Wijns, William, Saraste, Antti, Capodanno, Davide, Barbato, Emanuele, Funck-Brentano, Christian, Prescott, Eva, Storey, Robert F, Deaton, Christi, Cuisset, Thomas, Agewall, Stefan, Dickstein, Kenneth, Edvardsen, Thor, Escaned, Javier, Gersh, Bernard J, Svitil, Pavel, Gilard, Martine, Hasdai, David, Hatala, Robert, Mahfoud, Felix, Masip, Josep, Muneretto, Claudio, Valgimigli, Marco, Achenbach, Stephan, Bax, Jeroen J, Neumann FJ, Sechtem U, Banning AP, Bonaros N, Bueno H, Bugiardini R, Chieffo A, Crea F, Czerny M, Delgado V, Dendale P, Flachskampf FA, Gohlke H, Grove EL, James S, Katritsis D, Landmesser U, Lettino M, Matter CM, Nathoe H, Niessner A, Patrono C, Petronio AS, Pettersen SE, Piccolo R, Piepoli MF, Popescu BA, Räber L, Richter DJ, Roffi M, Roithinger FX, Shlyakhto E, Sibbing D, Silber S, Simpson IA, Sousa-Uva M, Vardas P, Witkowski A, Zamorano JL, Achenbach S, Agewall S, Barbato E, Bax JJ, Capodanno D, Cuisset T, Deaton C, Dickstein K, Edvardsen T, Escaned J, Funck-Brentano C, Gersh BJ, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Prescott E, Saraste A, Storey RF, Svitil P, Valgimigli M, Windecker S, Aboyans V, Baigent C, Collet JP, Dean V, Fitzsimons D, Gale CP, Grobbee D, Halvorsen S, Hindricks G, Iung B, Jüni P, Katus HA, Leclercq C, Lewis BS, Merkely B, Mueller C, Petersen S, Touyz RM, Benkhedda S, Metzler B, Sujayeva V, Cosyns B, Kusljugic Z, Velchev V, Panayi G, Kala P, Haahr-Pedersen SA, Kabil H, Ainla T, Kaukonen T, Cayla G, Pagava Z, Woehrle J, Kanakakis J, Tóth K, Gudnason T, Peace A, Aronson D, Riccio C, Elezi S, Mirrakhimov E, Hansone S, Sarkis A, Babarskiene R, Beissel J, Maempel AJC, Revenco V, de Grooth GJ, Pejkov H, Juliebø V, Lipiec P, Santos J, Chioncel O, Duplyakov D, Bertelli L, Dikic AD, Studenčan M, Bunc M, Alfonso F, Bäck M, Zellweger M, Addad F, Yildirir A, Sirenko Y, Clapp B, Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de pharmacologie médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département de Cardiologie [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE)-Assistance Publique - Hôpitaux de Marseille (APHM), Knuuti, Juhani, Wijns, William, Saraste, Antti, Capodanno, Davide, Barbato, Emanuele, Funck-Brentano, Christian, Prescott, Eva, Storey, Robert F, Deaton, Christi, Cuisset, Thoma, Agewall, Stefan, Dickstein, Kenneth, Edvardsen, Thor, Escaned, Javier, Gersh, Bernard J, Svitil, Pavel, Gilard, Martine, Hasdai, David, Hatala, Robert, Mahfoud, Felix, Masip, Josep, Muneretto, Claudio, Valgimigli, Marco, Achenbach, Stephan, Bax, Jeroen J, Neumann FJ, Sechtem U, Banning AP, Bonaros N, Bueno H, Bugiardini R, Chieffo A, Crea F, Czerny M, Delgado V, Dendale P, Flachskampf FA, Gohlke H, Grove EL, James S, Katritsis D, Landmesser U, Lettino M, Matter CM, Nathoe H, Niessner A, Patrono C, Petronio AS, Pettersen SE, Piccolo R, Piepoli MF, Popescu BA, Räber L, Richter DJ, Roffi M, Roithinger FX, Shlyakhto E, Sibbing D, Silber S, Simpson IA, Sousa-Uva M, Vardas P, Witkowski A, Zamorano JL, Achenbach S, Agewall S, Barbato E, Bax JJ, Capodanno D, Cuisset T, Deaton C, Dickstein K, Edvardsen T, Escaned J, Funck-Brentano C, Gersh BJ, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Prescott E, Saraste A, Storey RF, Svitil P, Valgimigli M, Windecker S, Aboyans V, Baigent C, Collet JP, Dean V, Delgado V, Fitzsimons D, Gale CP, Grobbee D, Halvorsen S, Hindricks G, Iung B, Jüni P, Katus HA, Landmesser U, Leclercq C, Lettino M, Lewis BS, Merkely B, Mueller C, Petersen S, Petronio AS, Richter DJ, Roffi M, Shlyakhto E, Simpson IA, Sousa-Uva M, Touyz RM, Benkhedda S, Metzler B, Sujayeva V, Cosyns B, Kusljugic Z, Velchev V, Panayi G, Kala P, Haahr-Pedersen SA, Kabil H, Ainla T, Kaukonen T, Cayla G, Pagava Z, Woehrle J, Kanakakis J, Tóth K, Gudnason T, Peace A, Aronson D, Riccio C, Elezi S, Mirrakhimov E, Hansone S, Sarkis A, Babarskiene R, Beissel J, Maempel AJC, Revenco V, de Grooth GJ, Pejkov H, Juliebø V, Lipiec P, Santos J, Chioncel O, Duplyakov D, Bertelli L, Dikic AD, Studenčan M, Bunc M, Alfonso F, Bäck M, Zellweger M, Addad F, Yildirir A, Sirenko Y, Clapp B, Clinical sciences, Cardio-vascular diseases, Cardiology, Knuuti, Juhani [0000-0003-3156-9593], Apollo - University of Cambridge Repository, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), University of Zurich, Knuuti, J., Wijns, W., Achenbach, S., Agewall, S., Barbato, E., Bax, J. J., Capodanno, D., Cuisset, T., Deaton, C., Dickstein, K., Edvardsen, T., Escaned, J., Funck-Brentano, C., Gersh, B. J., Gilard, M., Hasdai, D., Hatala, R., Mahfoud, F., Masip, J., Muneretto, C., Prescott, E., Saraste, A., Storey, R. F., Svitil, P., Valgimigli, M., Windecker, S., Aboyans, V., Baigent, C., Collet, J. -P., Dean, V., Delgado, V., Fitzsimons, D., Gale, C. P., Grobbee, D. E., Halvorsen, S., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Landmesser, U., Leclercq, C., Lettino, M., Lewis, B. S., Merkely, B., Mueller, C., Petersen, S., Petronio, A. S., Richter, D. J., Roffi, M., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Touyz, R. M., Benkhedda, S., Metzler, B., Sujayeva, V., Cosyns, B., Kusljugic, Z., Velchev, V., Panayi, G., Kala, P., Haahr-Pedersen, S. A., Kabil, H., Ainla, T., Kaukonen, T., Cayla, G., Pagava, Z., Woehrle, J., Kanakakis, J., Toth, K., Gudnason, T., Peace, A., Aronson, D., Riccio, C., Elezi, S., Mirrakhimov, E., Hansone, S., Sarkis, A., Babarskiene, R., Beissel, J., Cassar Maempel, A. J., Revenco, V., de Grooth, G. J., Pejkov, H., Juliebo, V., Lipiec, P., Santos, J., Chioncel, O., Duplyakov, D., Bertelli, L., Dikic, A. D., Studencan, M., Bunc, M., Alfonso, F., Back, M., Zellweger, M., Addad, F., Yildirir, A., Sirenko, Y., and Clapp, B.
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anti-ischaemic drug ,chronic coronary syndromes ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,lipid-lowering drugs ,Diagnostic Techniques, Cardiovascular ,antithrombotic therapy ,Disease ,030204 cardiovascular system & hematology ,Guideline ,Coronary artery disease ,0302 clinical medicine ,Disease management (health) ,Societies, Medical ,ComputingMilieux_MISCELLANEOUS ,chronic coronary syndrome ,angina pectori ,Disease Management ,food and beverages ,imaging ,risk assessment ,Syndrome ,3. Good health ,Natural history ,Europe ,Cardiology ,Cardiology and Cardiovascular Medicine ,coronary artery disease ,medicine.medical_specialty ,lifestyle modifications ,anti-ischaemic drugs ,Ischemia ,610 Medicine & health ,vasospastic angina ,Guidelines ,Revascularization ,diagnostic testing ,11171 Cardiocentro Ticino ,2705 Cardiology and Cardiovascular Medicine ,03 medical and health sciences ,angina pectoris ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,medicine ,Journal Article ,Humans ,business.industry ,screening ,fungi ,030229 sport sciences ,medicine.disease ,lipid-lowering drug ,Angina pectoris ,Anti-ischaemic drugs ,Antithrombotic therapy ,Chronic coronary syndromes ,Diagnostic testing ,Imaging ,Lifestyle modifications ,Lipid-lowering drugs ,Microvascular angina ,Myocardial ischaemia ,Myocardial revascularization ,Risk assessment ,Screening ,Vasospastic angina ,myocardial ischaemia ,myocardial revascularization ,Heart failure ,microvascular angina ,Chronic Disease ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,lifestyle modification ,Coronary Artery Disease/diagnosis ,business ,Fibrinolytic agent - Abstract
Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This process can be modified by lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve disease stabilization or regression. The disease can have long, stable periods but can also become unstable at any time, typically due to an acute atherothrombotic event caused by plaque rupture or erosion. However, the disease is chronic, most often progressive, and hence serious, even in clinically apparently silent periods. The dynamic nature of the CAD process results in various clinical presentations, which can be conveniently categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS). The Guidelines presented here refer to the management of patients with CCS. The natural history of CCS is illustrated in Figure 1.
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- 2019
45. Management of myocardial revascularisation failure: an expert consensus document of the EAPCI
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Stefanini G. G., Alfonso F., Barbato E., Byrne R. A., Capodanno D., Colleran R., Escaned J., Giacoppo D., Kunadian V., Lansky A., Mehilli J., Neumann F. -J., Regazzoli D., Sanz-Sanchez J., Wijns W., Baumbach A., Vahanian A., Stefanini, G. G., Alfonso, F., Barbato, E., Byrne, R. A., Capodanno, D., Colleran, R., Escaned, J., Giacoppo, D., Kunadian, V., Lansky, A., Mehilli, J., Neumann, F. -J., Regazzoli, D., Sanz-Sanchez, J., Wijns, W., Baumbach, A., and Vahanian, A.
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medicine.medical_specialty ,Percutaneous ,Consensus ,Bypass grafting ,Stent thrombosi ,Psychological intervention ,MEDLINE ,Multidisciplinary Heart Team ,Consensu ,Coronary Artery Disease ,Coronary artery disease ,Quality of life ,medicine ,Myocardial Revascularization ,Humans ,Intensive care medicine ,Prior PCI ,business.industry ,Myocardial revascularisation ,Expert consensus ,Drug-Eluting Stents ,medicine.disease ,Treatment Outcome ,Quality of Life ,Saphenous vein graft ,Cardiology and Cardiovascular Medicine ,business ,In-stent restenosi ,Prior cardiovascular surgery ,Human - Abstract
Myocardial revascularisation represents the most frequently performed therapeutic intervention worldwide. Current percutaneous and surgical revascularisation techniques provide excellent short- and long-term clinical outcomes. However, despite the technological and procedural advances with the widespread use of drug-eluting stents and arterial bypass grafts in contemporary practice, a considerable proportion of patients require repeat revascularisation procedures during long-term follow-up. The need for repeat revascularisation has a major impact on patients' quality of life and is associated with a significant economic burden. This consensus document summarises the views on the management of myocardial revascularisation failure of an expert panel of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). The present document provides a broad and pragmatic overview of the clinical management of myocardial revascularisation failure with a focus on the three key underlying mechanisms leading to repeat revascularisation: 1) failure of percutaneous coronary interventions, 2) failure of coronary artery bypass grafting, and 3) progression of coronary artery disease in native coronary segments previously untreated. The aim of the present position document is to provide a patient-oriented approach for the management of myocardial revascularisation failure.
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- 2020
46. [Role of proteinuria in clinical research: for each old-answer, a new key-question.]
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Provenzano M., Garofalo C., Chiodini P., Mancuso C., Barbato E., Nicola L. D., Andreucci M., Provenzano, M., Garofalo, C., Chiodini, P., Mancuso, C., Barbato, E., Nicola, L. D., and Andreucci, M.
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urogenital system ,Prognosi ,urologic and male genital diseases ,Cardiovascular risk ,Prognosis ,female genital diseases and pregnancy complications ,End-stage-kidney-disease ,Proteinuria ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Risk Factors ,Chronic kidney disease ,Albuminuria ,Humans ,Kidney Failure, Chronic ,Kidney Diseases - Abstract
The presence of proteinuria, i.e. an abnormal amount of proteins in the urine is a well documented cardiovascular (CV) and renal risk factor either in the general population or in high-risk populations such as patients with type 2 diabetes, previous CV disease and patients under regular nephrology care. Indeed, the increase in proteinuria levels, even if of small entity, is associated to a faster decline in renal function over time, increased risk of End-Stage-Kidney-Disease and CV mortality. The deleterious effect of proteinuria on the kidney is attributable to the primitive glomerular damage as well as to the direct toxicity the proteinuria exerts on the tubule-interstitium. In addition, the more general association with the increased CV risk can be explained by the evidence that proteinuria can be considered a marker of systemic and renal endothelial damage. A reduction in proteinuria over time (a 30% decrease after 6 months of treatment in proteinuria is considered acceptable) as response to antihypertensive or antiproteinuric drugs protects against the development of all mentioned endpoints. Further studies are needed to better clarify: What is the normal value of proteinuria excretion, how many measures should be done during follow-up to truely assess the risk of future outcomes, what is the exact prognostic role of proteinuria.
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- 2020
47. Fractional Flow Reserve–Based Coronary Artery Bypass Surgery: Current Evidence and Future Directions
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Spadaccio, C., Glineur, D., Barbato, E., Di Franco, A., Oldroyd, K. G., Biondi-Zoccai, G., Crea, Filippo, Fremes, S. E., Angiolillo, D. J., Gaudino, Mario Fulvio Luigi, Spadaccio, C., Glineur, D., Barbato, E., Di Franco, A., Oldroyd, K. G., Biondi-Zoccai, G., Crea, F., Fremes, S. E., Angiolillo, D. J., and Gaudino, M.
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Cardiac Catheterization ,Coronary Artery Bypa ,Predictive Value of Test ,Coronary Artery Disease ,Coronary Angiography ,Fractional Flow Reserve ,FFR ,Article ,Fractional Flow Reserve, Myocardial ,surgical procedures, operative ,Treatment Outcome ,Predictive Value of Tests ,myocardial revascularization ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Myocardial ,Humans ,Coronary Artery Bypass ,CABG ,Vascular Patency ,Human - Abstract
Fractional flow reserve (FFR) provides an objective measurement of the severity of ischemia caused by coronary stenoses in downstream myocardial regions. Data from the interventional cardiology realm have suggested benefits of a FFR-guided percutaneous coronary intervention (PCI) strategy. Limited evidence is available on the use of FFR to guide coronary artery bypass grafting (CABG). The most recent data have shown that FFR might simplify CABG procedures and optimize patency of arterial grafts without any clear impact on clinical outcomes. The aim of this review is to summarize the available data on FFR-based CABG and discuss the rationale and potential consequences of a switch towards FFR-based surgical revascularization strategy.
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- 2020
48. Physiological and angiographic outcomes of PCI in calcified lesions after rotational atherectomy or intravascular lithotripsy
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Gallinoro, E, Monizzi, G, Sonck, J, Candreva, A, Mileva, N, Nagumo, S, Munhoz, D, Buytaert, D, Mastrangelo, A, Andreini, D, Galli, S, Bartorelli, A L, Barbato, E, De Bruyne, B, Collet, C, University of Zurich, and Collet, C
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Atherectomy, Coronary ,Fractional Flow Reserve, Myocardial ,Percutaneous Coronary Intervention ,Treatment Outcome ,Lithotripsy ,10209 Clinic for Cardiology ,Humans ,610 Medicine & health ,Coronary Artery Disease ,Cardiology and Cardiovascular Medicine ,Coronary Angiography ,Vascular Calcification ,2705 Cardiology and Cardiovascular Medicine - Abstract
Percutaneous coronary interventions (PCI) in calcified coronary artery lesions are associated with impaired stent expansion, higher rate of periprocedural complications and cardiac mortality. Lesion preparation using calcium modifying techniques such as Rotational Atherectomy (RA) or Intravascular Lithotripsy (IVL) has been advocated. Studies comparing these technologies are lacking. We aimed to compare in-stent pressure gradients, evaluated by vessel fractional flow reserve (vFFR), in calcific lesions treated using either RA or IVL.Patients undergoing either RA- or IVL-assisted PCI from two European centers were included. Propensity score matching (1:2) was performed to control for potential bias. Primary outcome was post-PCI in-stent pressure gradients calculated by vFFR (vFFRgrad). Secondary outcomes included the proportion of patients with complete functional revascularization defined as distal vFFR post-PCI (vFFRpost) ≥ 0.90.From a cohort of 210 patients, 105 matched patients (70 RA and 35 IVL) were included. Pre-PCI vFFR did not differ between groups (0.65 ± 0.13 RA and 0.67 ± 0.11 IVL). After PCI, in-stent pressure gradients were significantly lower in the IVL group (0.032 ± 0.026 vs 0.043 ± 0.026 in the RA group, p = 0.024). The proportions of vessels with functional complete revascularization was similar between the two groups (32.9% vs. 37.1% in the RA and IVL group, respectively; p = 0.669).Calcific lesions preparation with IVL is effective and resulted in lower in-stent pressure gradients compared to RA. Approximately one third of the patients undergoing PCI for a severely calcified lesion achieved functional revascularization with no difference between rotational RA and IVL.
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- 2021
49. 652: Microtubule stability is a regulator of the circadian timing system in cystic fibrosis
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Barbato, E., primary, Darrah, R., additional, and Kelley, T., additional
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- 2021
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- View/download PDF
50. Angiography vs physiology-based deferral of revascularization in patients with reduced left ventricular ejection fraction: a 10-year clinical follow-up
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Gallinoro, E, primary, Paolisso, P, additional, Bermpeis, K, additional, Peregrina, E F, additional, Candreva, A, additional, Esposito, G, additional, Fabbricatore, D, additional, Sonck, J, additional, Di Gioia, G, additional, Vanderheyden, M, additional, Bartunek, J, additional, Collet, C, additional, De Bruyne, B, additional, and Barbato, E, additional
- Published
- 2021
- Full Text
- View/download PDF
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