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1. Correction: Clinical and cost-effectiveness of a New psychosocial intervention to support Independence in Dementia (NIDUS-family) for family carers and people living with dementia in their own homes: a randomised controlled trial

Author

Burton, Alexandra, Rapaport, Penny, Palomo, Marina, Lord, Kathryn, Budgett, Jessica, Barber, Julie, Hunter, Rachael, Butler, Laurie, Vickerstaff, Victoria, Rockwood, Kenneth, Ogden, Margaret, Smith, Debs, Lang, Iain, Livingston, Gill, Dow, Briony, Kales, Helen, Manthorpe, Jill, Walters, Kate, Hoe, Juanita, Orgeta, Vasiliki, Samus, Quincy, and Cooper, Claudia

Published
2024
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2. Feasibility and acceptability of NIDUS-Professional, a training and support intervention for homecare workers caring for clients living with dementia: a cluster-randomised feasibility trial protocol

Author

Zabihi, Sedigheh, Duffy, Larisa, Kelleher, Daniel, Lord, Kathryn, Dar, Ayesha, Koutsoubelis, Freya, Banks, Sara, Rapaport, Penny, Mason, Clare, Vickerstaff, Victoria, Barber, Julie A, Manthorpe, Jill, Walters, Kate, Lang, Iain, Rockwood, Kenneth, Duggan, Sandra, Kales, Helen, and Cooper, Claudia

Subjects
Health Services and Systems, Nursing, Health Sciences, Dementia, Clinical Trials and Supportive Activities, Clinical Research, Acquired Cognitive Impairment, Brain Disorders, Management of diseases and conditions, 7.1 Individual care needs, Neurological, Humans, Feasibility Studies, Single-Blind Method, Caregivers, Home Care Services, Randomized Controlled Trials as Topic, dementia, old age psychiatry, clinical trials, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

IntroductionMost people living with dementia want to remain living in their own homes, and are supported to do so by family carers and homecare workers. There are concerns that homecare is often unable to meet the needs of this client group, with limited evidence regarding effective interventions to improve it for people living with dementia. We have developed a training and support programme for homecare workers (NIDUS-Professional) to be delivered alongside support sessions for people living with dementia and their family carers (NIDUS-Family). We aim to assess (1) its acceptability among homecare workers and employing agencies, and (2) the feasibility of homecare workers, people living with dementia and their family carers completing the outcomes of intervention in a future randomised controlled trial.Methods and analysisThis is a cluster-randomised (2:1) single-blind, multisite feasibility trial. We aim to recruit 60-90 homecare workers, 30-60 clients living with dementia and their family carers through 6-9 English homecare agencies. In the intervention arm, homecare staff will be offered six group sessions on video call over three months, followed by monthly group sessions over the subsequent three-month period. Outcome measures will be collected at baseline and at six months.Ethics and disseminationThe study received ethical approval on 7 January 2020 from the Camden & King's Cross Research Ethics Committee. Study reference: 19/LO/1667. Findings will be disseminated through a peer-reviewed journal, conference presentation and blog to research and clinical audiences; we will attend forums to present findings to participating homecare agencies and their clients.Trial registration numberISRCTN15757555.

Published
2022

3. Clinical effectiveness of DREAMS START (Dementia Related Manual for Sleep; Strategies for Relatives) versus usual care for people with dementia and their carers: a single-masked, phase 3, parallel-arm, superiority randomised controlled trial

Author

Rapaport, Penny, Amador, Sarah, Adeleke, Mariam O, Barber, Julie A, Banerjee, Sube, Charlesworth, Georgina, Clarke, Chris, Espie, Colin A, Gonzalez, Lina, Horsley, Rossana, Hunter, Rachael, Kyle, Simon D, Manela, Monica, Raczek, Malgorzata, Walker, Zuzana, Webster, Lucy, Yuan, Hang, and Livingston, Gill

Published
2024
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5. Clinical and cost-effectiveness of a New psychosocial intervention to support Independence in Dementia (NIDUS-family) for family carers and people living with dementia in their own homes: a randomised controlled trial

Author

Burton, Alexandra, Rapaport, Penny, Palomo, Marina, Lord, Kathryn, Budgett, Jessica, Barber, Julie, Hunter, Rachael, Butler, Laurie, Vickerstaff, Jessica, Rockwood, Kenneth, Ogden, Margaret, Smith, Debs, Lang, Iain, Livingston, Gill, Dow, Briony, Kales, Helen, Manthorpe, Jill, Walters, Kate, Hoe, Juanita, Orgeta, Vasiliki, Samus, Quincy, and Cooper, Claudia

Subjects
Allied Health and Rehabilitation Science, Health Services and Systems, Nursing, Health Sciences, Clinical Research, Brain Disorders, Behavioral and Social Science, Neurodegenerative, Clinical Trials and Supportive Activities, Aging, Alzheimer's Disease, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, 7.1 Individual care needs, Management of diseases and conditions, Neurological, Good Health and Well Being, COVID-19, Caregivers, Cost-Benefit Analysis, Humans, Pandemics, Psychosocial Intervention, Quality of Life, SARS-CoV-2, Family carer, Psychosocial intervention, Independence, NIDUS study team, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, General & Internal Medicine, Clinical sciences, Epidemiology, Health services and systems
Abstract

BackgroundMost people living with dementia want to remain living in their own homes and are supported to do so by family carers. No interventions have consistently demonstrated improvements to people with dementia's life quality, functioning, or other indices of living as well as possible with dementia. We have co-produced, with health and social care professionals and family carers of people with dementia, a new intervention (NIDUS-family). To our knowledge, NIDUS-family is the first manualised intervention that can be tailored to personal goals of people living with dementia and their families and is delivered by facilitators without clinical training. The intervention utilizes components of behavioural management, carer support, psychoeducation, communication and coping skills training, enablement, and environmental adaptations, with modules selected to address dyads' selected goals. We will evaluate the effect of NIDUS-family and usual care on goal attainment, as measured by Goal Attainment Scaling (GAS) rated by family carers, compared to usual care alone at 12-month follow-up. We will also determine whether NIDUS-family and usual care is more cost-effective than usual care alone over 12 months.MethodsA randomised, two-arm, single-masked, multi-site clinical trial involving 297 people living with dementia-family carer dyads. Dyads will be randomised 2:1 to receive the NIDUS-family intervention with usual care (n = 199) or usual care alone (n = 98). The intervention group will be offered, over 1 year, via 6-8 video call or telephone sessions (or face to face if COVID-19 restrictions allow in the recruitment period) in the initial 6 months, followed by telephone follow-ups every 1-2 months to support implementation, with a trained facilitator.DiscussionIncreasing the time lived at home by people living with dementia is likely to benefit lives now and in the future. Our intervention, which we adapted to include remote delivery prior to trial commencement due to the COVID-19 pandemic, aims to address barriers to living as well and as independently as possible that distress people living with dementia, exacerbate family carer(s) stress, negatively affect relationships, lead to safety risks, and frequently precipitate avoidable moves to a care home.Trial registrationInternational Standard Randomised Controlled Trials Number ISRCTN11425138 . Registered on 7 October 2019.

Published
2021

6. Social connectedness and dementia prevention: Pilot of the APPLE-Tree video-call intervention during the Covid-19 pandemic

Author

Cooper, Claudia, Mansour, Hassan, Carter, Christine, Rapaport, Penny, Morgan-Trimmer, Sarah, Marchant, Natalie L, Poppe, Michaela, Higgs, Paul, Brierley, Janine, Solomon, Noa, Budgett, Jessica, Bird, Megan, Walters, Kate, Barber, Julie, Wenborn, Jennifer, Lang, Iain A, Huntley, Jonathan, Ritchie, Karen, Kales, Helen C, Brodaty, Henry, Aguirre, Elisa, Betz, Anna, and Palomo, Marina

Subjects
Health Services and Systems, Health Sciences, Clinical Trials and Supportive Activities, Brain Disorders, Behavioral and Social Science, Aging, Dementia, Mental Health, Clinical Research, Prevention, Acquired Cognitive Impairment, Nutrition, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Good Health and Well Being, Adult, COVID-19, Humans, Pandemics, SARS-CoV-2, cognition, mild cognitive impairment, eHealth, remote, internet, subjective cognitive decline, older adult, Clinical Sciences, Nursing, Cognitive Sciences, Geriatrics, Health services and systems
Abstract

Background and objectivesThe Covid-19 pandemic reduced access to social activities and routine health care that are central to dementia prevention. We developed a group-based, video-call, cognitive well-being intervention; and investigated its acceptability and feasibility; exploring through participants' accounts how the intervention was experienced and used in the pandemic context.Research design and methodWe recruited adults aged 60+ years with memory concerns (without dementia). Participants completed baseline assessments and qualitative interviews/focus groups before and after the 10-week intervention. Qualitative interview data and facilitator notes were integrated in a thematic analysis.Results12/17 participants approached completed baseline assessments, attended 100/120 (83.3%) intervention sessions and met 140/170 (82.4%) of goals set. Most had not used video calling before. In the thematic analysis, our overarching theme was social connectedness. Three sub-themes were as follows: Retaining independence and social connectedness: social connectedness could not be at the expense of independence; Adapting social connectedness in the pandemic: participants strived to compensate for previous social connectedness as the pandemic reduced support networks; Managing social connections within and through the intervention: although there were tensions, for example, between sharing of achievements feeling supportive and competitive, participants engaged with various lifestyle changes; social connections supported group attendance and implementation of lifestyle changes.Discussion and implicationsOur intervention was acceptable and feasible to deliver by group video-call. We argue that dementia prevention is both an individual and societal concern. For more vulnerable populations, messages that lifestyle change can help memory should be communicated alongside supportive, relational approaches to enabling lifestyle changes.

Published
2021

7. A psychosocial goal-setting and manualised support intervention for independence in dementia (NIDUS-Family) versus goal setting and routine care: a single-masked, phase 3, superiority, randomised controlled trial

Author

Cooper, Claudia, Vickerstaff, Victoria, Barber, Julie, Phillips, Rosemary, Ogden, Margaret, Walters, Kate, Lang, Iain, Rapaport, Penny, Orgeta, Vasiliki, Rockwood, Kenneth, Banks, Sara, Palomo, Marina, Butler, Laurie T, Lord, Kathyrn, Livingston, Gill, Banerjee, Sube, Manthorpe, Jill, Dow, Briony, Hoe, Juanita, Hunter, Rachael, Samus, Quincy, and Budgett, Jessica

Published
2024
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9. Effectiveness-implementation of COPD case finding and self-management action plans in low- and middle-income countries: global excellence in COPD outcomes (GECo) study protocol

Author

Siddharthan, Trishul, Pollard, Suzanne L, Quaderi, Shumonta A, Mirelman, Andrew J, Cárdenas, Maria Kathia, Kirenga, Bruce, Rykiel, Natalie A, Miranda, J Jaime, Shrestha, Laxman, Chandyo, Ram K, Cattamanchi, Adithya, Michie, Susan, Barber, Julie, Checkley, William, and Hurst, John R

Subjects
Health Services and Systems, Health Sciences, Chronic Obstructive Pulmonary Disease, Lung, Clinical Trials and Supportive Activities, Clinical Research, Health Services, Comparative Effectiveness Research, Prevention, Respiratory, Adult, Cost-Benefit Analysis, Humans, Peak Expiratory Flow Rate, Pulmonary Disease, Chronic Obstructive, Randomized Controlled Trials as Topic, Self Care, Spirometry, Surveys and Questionnaires, COPD, COPD exacerbations, COPD case finding, COPD action plan, Non-communicable disease, Self-management, GECo Study Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, General & Internal Medicine, Clinical sciences, Epidemiology, Health services and systems
Abstract

BackgroundChronic obstructive pulmonary disease (COPD) is the end result of a susceptible individual being exposed to sufficiently deleterious environmental stimuli. More than 90% of COPD-related deaths occur in low- and middle-income countries (LMICs). LMICs face unique challenges in managing COPD; for example, deficient primary care systems present challenges for proper diagnosis and management. Formal diagnosis of COPD requires quality-assured spirometry, which is often limited to urban health centres. Similarly, standard treatment options for COPD remain limited where few providers are trained to manage COPD. The Global Excellence in COPD Outcomes (GECo) studies aim to assess the performance of a COPD case-finding questionnaire with and without peak expiratory flow (PEF) to diagnose COPD, and inform the effectiveness and implementation of COPD self-management Action Plans in LMIC settings. The ultimate goal is to develop simple, low-cost models of care that can be implemented in LMICs. This study will be carried out in Nepal, Peru and Uganda, three distinct LMIC settings.Methods/designWe aim to assess the diagnostic accuracy of a simple questionnaire with and without PEF to case-find COPD (GECo1), and examine the effectiveness, cost-effectiveness and implementation of a community-health-worker-supported self-management Action Plan strategy for managing exacerbations of COPD (GECo2). To achieve the first aim, we will enrol a randomly selected sample of up to 10,500 adults aged ≥ 40 years across our three sites, with the goal to enrol 240 participants with moderate-to-severe COPD in to GECo2. We will apply two case-finding questionnaires (Lung Function Questionnaire and CAPTURE) with and without PEF and compare performance against spirometry. We will report ROC areas, sensitivity and specificity. Individuals who are identified as having COPD grades B-D will be invited to enrol in an effectiveness-implementation hybrid randomised trial of a multi-faceted COPD self-management Action Plan intervention delivered by CHWs. The intervention group will receive (1) COPD education, (2) facilitated-self management Action Plans for COPD exacerbations and (3) monthly visits by community health workers. The control group will receive COPD education and standard of care treatment provided by local health providers. Beginning at baseline, we will measure quality of life with the EuroQol-5D (EQ-5D) and St. George's Respiratory Questionnaire (SGRQ) every 3 months over a period of 1 year. The primary endpoint is SGRQ at 12 months. Quality-adjusted life years (QALYs) using the Short-Form 36 version 2 will also be calculated. We will additionally assess the acceptability and feasibility of implementing COPD Action Plans in each setting among providers and individuals with COPD.DiscussionThis study should provide evidence to inform the use of pragmatic models of COPD diagnosis and management in LMIC settings.Trial registrationNCT03359915 (GECo1). Registered on 2 December 2017 and NCT03365713 (GECo2). Registered on 7 December 2017. Trial acronym: Global Excellence in COPD Outcomes (GECo1; GECo2).

Published
2018

10. Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV

Author

Booth, John, Waters, Anele, Hand, James, Clarke, Chris, Murphy, Sarah, Murphy, Maurice, Campbell, Marion, Clarke, Amanda, Richardson, Celia, Knott, Alyson, Weir, Gemma, Cleig, Rebecca, Soviarova, Helena, Barbour, Lisa, Adams, Tanya, Kennard, Vicky, Trevitt, Vittorio, Jones, Rachael, Levy, Jeremy, Schoolmeester, Alexandra, Duro, Serah, Hilton, Rachel, Fox, Julie, Rabuya, May, Hamzah, Lisa, Jordan, Deborah, Solano, Teresa, Uzu, Hiromi, Williams, Karen, Lwanga, Julianne, Reid-Amoruso, Linda Ekaette, Gamlen, Hannah, Stocker, Robert J., Ryan, Fiona, Mahiouz, Karina, Cheetham, Tess, Williams, Claire, Nori, Achyuta, Thomas, Caroline, Venkateshwaran, Sivaraj, Doctor, Jessica, Berlanga, Andrea, Post, Frank, Santana-Suarez, Beatriz, McQueen, Leigh, Bhagwandin, Priya, Campbell, Lucy, Barbini, Bee, Wandolo, Emily, Appleby, Tim, Driver, Lois, Parr, Sophy, Deng, Hongbo, Barber, Julie, Crowe, Andrew, Taylor, Chris, Poulton, Mary, Boateng, Vida, Klein, Marie-Pierre, O'Brien, Caitlin, Ohene-Adomako, Samuel, Buckingham, Christian, Trotman, Daniel, Quinn, Killian, Flanagan, Kate, Sullivan, Verity, Middleditch, Holly, Samuel, Itty, Hamlyn, Elizabeth, McDonald, Candice, Canoso, Ana, Agbasi, Emeka, Liskova, Maria, Barber, Sarah, Samarawickrama, Amanda, Ottaway, Zoe, Norcross, Claire, Oliveira, Amelia, Bramham, Kate, Minton, Jane, Lamont, Gary, Cross, Ruby, Saiyad, Gaushiya, Ahmed, Shadia, Ashworth, Rebecca, Window, Nicola, Murira, J., Phyu, Khine, Ustianowski, Andrew, Lindergard, Gabriella, Shaw, Jonathan, Holland, Sarah, Fox, Claire, Flaherty, Jan, Bevan, Margaret-Anne, George, Valerie, Chadwick, David, Branch, Marie, Lambert, Pauline, Craggs, Adele, Pett, Sarah, Lukha, Hinal, Vora, Nina, Fiorino, Marzia, Nunez, Maria Muller, Sally, Deirdre, Burns, James E., Pool, Erica, Matthews, Rebecca, Price, David Ashley, Stothard, Tara, Patel, Bijal, McVittie, Ian, Kennedy, Ciara, Shwab, Uli, Payne, Brendan, Duncan, Sarah, Dixon, Jill, Schmid, Mathias, Evans, Adam, Duncan, Christopher, Hunter, Ewan, Taha, Yusri, Astill, Natasha, Winkler, Cheryl, Binns-Roemer, Elizabeth, David, Victor, Ainsworth, Jonathan, Vincent, Rachel, Kegg, Stephen, Saad, Chloe, Skinner, Sarah, Azzoug, Hocine, Russell, Judith, Moussaoui, Tarik, Mabonga, Emily, Ward, Donna, Francoise, J., Larbi, W., Mitchell, Sue, Manning, A., Russell, V., Burns, Fiona, Harber, Mark, Ngwu, Nnenna, Edwards, Jonathan, Hemat, Nargis, Fernandez, Tom, Ferro, Filippo, Ferreira, Jorge, Nightingale, Alice, Oakes-Monger, Tasha, Matila, Darwin, Nogueira, Pedro, Mutagwanya, Victoria, Cosgrove, Catherine, Isitt, Catherine Emily, Webb, Helen, Popoola, Joyce, Korley, Kate, Mencias, Mark, Ribeiro, Patricia, Ramkhelawn, Rajeshwar, Lara, Sandra Oliva, Sajijad, Sara, Winston, Alan, Shaw, Amber, Petersen, Claire, Ring, Kyle, Rosenvinge, Melanie, Moyo, Thembi, Odong, Faith, Gantert, Katherine, Ibe, Tina, Onyango, Denis, Sabin, Caroline, Hill, Teresa, Hung, Rachel K.Y., Booth, John W., Price, David A., Sabin, Caroline A., Winkler, Cheryl A., and Post, Frank A.

Published
2022
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11. Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV

Author

Booth, John, Waters, Anele, Hand, James, Clarke, Chris, Murphy, Sarah, Murphy, Maurice, Campbell, Marion, Clarke, Amanda, Richardson, Celia, Knott, Alyson, Weir, Gemma, Cleig, Rebecca, Soviarova, Helena, Barbour, Lisa, Adams, Tanya, Kennard, Vicky, Trevitt, Vittorio, Jones, Rachael, Levy, Jeremy, Schoolmeester, Alexandra, Duro, Serah, Hilton, Rachel, Fox, Julie, Rabuya, May, Hamzah, Lisa, Jordan, Deborah, Solano, Teresa, Uzu, Hiromi, Williams, Karen, Lwanga, Julianne, Reid-Amoruso, Linda Ekaette, Gamlen, Hannah, Stocker, Robert J., Ryan, Fiona, Mahiouz, Karina, Cheetham, Tess, Williams, Claire, Nori, Achyuta, Thomas, Caroline, Venkateshwaran, Sivaraj, Doctor, Jessica, Berlanga, Andrea, Post, Frank, Santana-Suarez, Beatriz, McQueen, Leigh, Bhagwandin, Priya, Campbell, Lucy, Barbini, Bee, Wandolo, Emily, Appleby, Tim, Driver, Lois, Parr, Sophy, Deng, Hongbo, Barber, Julie, Crowe, Andrew, Taylor, Chris, Poulton, Mary, Boateng, Vida, Klein, Marie-Pierre, O’Brien, Caitlin, Ohene-Adomako, Samuel, Buckingham, Christian, Trotman, Daniel, Quinn, Killian, Flanagan, Kate, Sullivan, Verity, Middleditch, Holly, Samuel, Itty, Hamlyn, Elizabeth, McDonald, Candice, Canoso, Ana, Agbasi, Emeka, Liskova, Maria, Barber, Sarah, Samarawickrama, Amanda, Ottaway, Zoe, Norcross, Claire, Oliveira, Amelia, Bramham, Kate, Minton, Jane, Lamont, Gary, Cross, Ruby, Saiyad, Gaushiya, Ahmed, Shadia, Ashworth, Rebecca, Window, Nicola, Murira, J., Phyu, Khine, Ustianowski, Andrew, Lindergard, Gabriella, Shaw, Jonathan, Holland, Sarah, Fox, Claire, Flaherty, Jan, Bevan, Margaret-Anne, George, Valerie, Chadwick, David, Branch, Marie, Lambert, Pauline, Craggs, Adele, Pett, Sarah, Lukha, Hinal, Vora, Nina, Fiorino, Marzia, Nunez, Maria Muller, Sally, Deirdre, Burns, James E., Pool, Erica, Matthews, Rebecca, Price, David Ashley, Stothard, Tara, Patel, Bijal, McVittie, Ian, Kennedy, Ciara, Shwab, Uli, Payne, Brendan, Duncan, Sarah, Dixon, Jill, Schmid, Mathias, Evans, Adam, Duncan, Christopher, Hunter, Ewan, Taha, Yusri, Astill, Natasha, Winkler, Cheryl, Binns-Roemer, Elizabeth, David, Victor, Ainsworth, Jonathan, Vincent, Rachel, Kegg, Stephen, Saad, Chloe, Skinner, Sarah, Azzoug, Hocine, Russell, Judith, Moussaoui, Tarik, Mabonga, Emily, Ward, Donna, Francoise, J., Larbi, W., Mitchell, Sue, Manning, A., Russell, V., Burns, Fiona, Harber, Mark, Ngwu, Nnenna, Edwards, Jonathan, Hemat, Nargis, Fernandez, Tom, Ferro, Filippo, Ferreira, Jorge, Nightingale, Alice, Oakes-Monger, Tasha, Matila, Darwin, Nogueira, Pedro, Mutagwanya, Victoria, Cosgrove, Catherine, Isitt, Catherine Emily, Webb, Helen, Popoola, Joyce, Korley, Kate, Mencias, Mark, Ribeiro, Patricia, Ramkhelawn, Rajeshwar, Lara, Sandra Oliva, Sajijad, Sara, Winston, Alan, Shaw, Amber, Petersen, Claire, Ring, Kyle, Rosenvinge, Melanie, Moyo, Thembi, Odong, Faith, Gantert, Katherine, Ibe, Tina, Onyango, Denis, Sabin, Caroline, Hill, Teresa, Hung, Rachel K.Y., Booth, John W., Price, David A., Sharpe, Claire C., Sabin, Caroline A., Winkler, Cheryl A., and Post, Frank A.

Published
2022
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12. A process evaluation of the NIDUS-Professional dementia training intervention for UK homecare workers

Author

Kelleher, Daniel, primary, Windle, Karen, additional, Randell, Rebecca, additional, Lord, Kathryn, additional, Duffy, Larisa, additional, Akhtar, Amirah, additional, Budgett, Jessica, additional, Zabihi, Sedigheh, additional, Banks, Sara, additional, Rapaport, Penny, additional, Lee, Teresa, additional, Barber, Julie, additional, Orgeta, Vasiliki, additional, Manthorpe, Jill, additional, Walters, Kate, additional, Rockwood, Kenneth, additional, Dow, Briony, additional, Hoe, Juanita, additional, Banerjee, Sube, additional, and Cooper, Claudia, additional

Published
2024
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14. Short-term effects of an unprecedented heatwave on intertidal bivalve populations: fisheries management surveys provide an incomplete picture.

Author

Raymond, Wendel W., Tobin, Elizabeth D., Barber, Julie S., Hayford, Hilary A., Raymond, Ann E. T., Speck, Camille A., Rogers, Doug, and Brown, Rana

Subjects
HEAT waves (Meteorology), FISHERY management, OYSTER populations, BIVALVES, INTERTIDAL organisms, TIDAL flats, INTERTIDAL zonation
Abstract

Introduction: Coastal marine ecosystems, are particularly susceptible to climate change. One such threat is atmospheric heatwaves, which are predicted to increase in frequency, duration, and intensity. Many intertidal organisms already live at the edge of their thermal tolerance limits and heatwaves can outstretch an organism's ability to compensate in the short term. In June 2021 the Pacific Northwest region of North America, including the Salish Sea, experienced a significant atmospheric heatwave during some of the lowest tides of the year. This was followed by numerous reports of dead and dying intertidal marine organisms region-wide. A semi-quantitative rapid assessment found a range of both species- and location-specific effects but generally recorded widespread negative impacts to intertidal shellfish species across the Salish Sea. Methods: Following these results, we opportunistically analyzed data collected by intertidal bivalve resource managers from the region. These datasets allowed us to examine regional density and size data for clam and oyster populations before and after the heatwave to increase our quantitative understanding of heatwave effects. Results: We found a range of responses including positive and negative effects of the heatwave on clam and oyster density. While we generally found small changes in bivalve size, some site-species combinations displayed large shifts in size frequency. Many of our analyses did not indicate even moderate statistical support, even with large changes in the mean, driven in part by high variability in the data. Time intervals between surveys, ranging from 2 to over 25 months, had little effect on observed variability indicating that any heatwave-induced effects may be masked by variability inherent to the population ecology and/or survey methodology. Discussion: This analysis has highlighted the need for intertidal resource managers, and the greater research community, to consider alternative survey approaches designed to constrain variability in order to detect the effects of acute or extreme events. With the effects of climate change predicted to become more intense, targeted survey approaches may be needed to detect the effects and implications of such events and to continue effective management of intertidal bivalves in the Salish Sea and worldwide. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Process evaluation of a New psychosocial goal-setting and manualised support intervention for Independence in Dementia (NIDUS-Family).

Author

Wyman, Danielle, Butler, Laurie T, Morgan-Trimmer, Sarah, Bright, Peter, Barber, Julie, Budgett, Jessica, Walters, Kate, Lang, Iain, Rapaport, Penny, Banks, Sara, Palomo, Marina, Orgeta, Vasiliki, Livingston, Gill, Rockwood, Kenneth, Lord, Kathryn, Manthorpe, Jill, Dow, Briony, Hoe, Juanita, and Cooper, Claudia

Subjects
TREATMENT of dementia, PSYCHOTHERAPY, RESEARCH funding, QUALITATIVE research, EVALUATION of human services programs, QUESTIONNAIRES, INTERVIEWING, GOAL (Psychology), SERVICES for caregivers, JUDGMENT sampling, DESCRIPTIVE statistics, TREATMENT effectiveness, FAMILIES, THEMATIC analysis, MATHEMATICAL models, RESEARCH methodology, PATIENT-professional relations, SOCIAL support, THEORY, DEMENTIA, CHANGE theory, WELL-being, CAREGIVER attitudes
Abstract

Introduction We report a mixed-methods process evaluation embedded within a randomised controlled trial. We aimed to test and refine a theory of change model hypothesising key causal assumptions to understand how the New Interventions for Independence in Dementia Study (NIDUS)-Family (a manualised, multimodal psychosocial intervention), was effective relative to usual care, on the primary outcome of Goal Attainment Scaling (GAS) over 1 year. Methods In 2021–2022, intervention-arm dyads completed an acceptability questionnaire developed to test causal assumptions. We conducted qualitative interviews with dyads and intervention facilitators, purposively selected for diverse follow-up GAS scores. We collected observational data from intervention session recordings. We thematically analysed data, then integrated qualitative and quantitative data. Results 174/204 (85.3%) dyads allocated to NIDUS-Family, fully completed it, 18 partially completed, while 12 received no intervention. We interviewed 27/192 (14%) of dyads receiving any sessions, and 9/10 facilitators; and observed 12 sessions. 47/192 (24.5%) of carers completed the acceptability questionnaire. We identified four themes: (A) 'Someone to talk to helps dyads feel supported'; (B) 'NIDUS-Family helps carers change their perspective'; (C) 'Personalisation helps people living with dementia maintain their identity' and (D) 'Small steps help dyads move forward'. Conclusion Key causal pathway mechanisms were: a respectful, trusting and impartial relationship with the facilitator: supporting the development of meaningful goals and support to find manageable solutions. Core implementation factors were delivery of the modules from a consistent facilitator across regular sessions. Core contextual factors influencing these mechanisms were dyadic participation and understanding of abilities. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The Impact of Specialist Care on Teenage and Young Adult Patient-Reported Outcomes in England: A BRIGHTLIGHT Study.

Author

Taylor, Rachel M., Whelan, Jeremy S., Barber, Julie A., Alvarez-Galvez, Javier, Feltbower, Richard G., Gibson, Faith, Stark, Dan P., and Fern, Lorna A.

Subjects
TUMOR treatment, MEDICAL care for teenagers, ATTITUDES toward illness, HEALTH status indicators, RESEARCH funding, TUMORS in children, CANCER patient medical care, MEDICAL care, QUESTIONNAIRES, HEALTH policy, AGE, DESCRIPTIVE statistics, LONGITUDINAL method, SURVEYS, RESEARCH, HEALTH outcome assessment, CANCER patient psychology, SOCIAL support, CONFIDENCE intervals, COMPARATIVE studies, PATIENTS' attitudes
Abstract

Purpose: In England, health care policy promotes specialized age-appropriate cancer services for teenagers and young adults (TYA), for those aged 13–24 years at diagnosis. Specialist Principal Treatment Centers (PTCs) provide enhanced age-specific care for TYA, although many still receive all or some of their care in adult or children's cancer services. Our aim was to determine the patient-reported outcomes associated with TYA-PTC based care. Methods: We conducted a multicenter cohort study, recruiting 1114 TYA aged 13–24 years at diagnosis. Data collection involved a bespoke survey at 6,12,18, 24, and 36 months after diagnosis. Confounder adjusted analyses of perceived social support, illness perception, anxiety and depression, and health status, compared patients receiving NO-TYA-PTC care with those receiving ALL-TYA-PTC and SOME-TYA-PTC care. Results: Eight hundred and thirty completed the first survey. There was no difference in perceived social support, anxiety, or depression between the three categories of care. Significantly higher illness perception was observed in the ALL-TYA-PTC and SOME-TYA-PTC group compared to the NO-TYA-PTC group, (adjusted difference in mean (ADM) score on Brief Illness Perception scale 2.28 (95% confidence intervals [CI] 0.48–4.09) and 2.93 [1.27–4.59], respectively, p = 0.002). Similarly, health status was significantly better in the NO-TYA-PTC (ALL-TYA-PTC: ADM −0.011 [95%CI −0.046 to 0.024] and SOME-TYA-PTC: −0.054 [−0.086 to −0.023]; p = 0.006). Conclusion: The reason for the difference in perceived health status is unclear. TYA who accessed a TYA-PTC (all or some care) had higher perceived illness. This may reflect greater education and promotion of self-care by health care professionals in TYA units. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Process evaluation of a New psychosocial goal-setting and manualised support intervention for Independence in Dementia (NIDUS-Family)

Author

Wyman, Danielle Laura, primary, Butler, L T, additional, Morgan-Trimmer, Sarah, additional, Bright, Peter, additional, Barber, Julie, additional, Budgett, Jessica, additional, Walters, Kate, additional, Lang, I, additional, Rapaport, P, additional, Banks, Sara, additional, Palomo, Marina, additional, Orgeta, Vasiliki, additional, Livingston, Gill, additional, Rockwood, K, additional, Lord, K, additional, Manthorpe, J, additional, Dow, B, additional, Hoe, J, additional, and Cooper, Claudia, additional

Published
2024
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18. Clinical and cost-effectiveness of DREAMS START (Dementia RElAted Manual for Sleep; STrAtegies for RelaTives) for people living with dementia and their carers: a study protocol for a parallel multicentre randomised controlled trial

Author

Rapaport, Penny, primary, Amador, Sarah, additional, Adeleke, Mariam, additional, Banerjee, Sube, additional, Barber, Julie, additional, Charlesworth, Georgina, additional, Clarke, Christopher, additional, Connell, Caroline, additional, Espie, Colin, additional, Gonzalez, Lina, additional, Horsley, Rossana, additional, Hunter, Rachael, additional, Kyle, Simon D, additional, Manela, Monica, additional, Morris, Sarah, additional, Pikett, Liam, additional, Raczek, Malgorzata, additional, Thornton, Emma, additional, Walker, Zuzana, additional, Webster, Lucy, additional, and Livingston, Gill, additional

Published
2024
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19. Clinical effectiveness of the NIDUS randomised control trial of a tailored, goal‐focused intervention for increasing goal attainment in people living with dementia and their family carers

Author

Budgett, Jessica, primary, Barber, Julie, additional, Hunter, Rachael M, additional, Rapaport, Penny, additional, Lord, Kathryn, additional, Livingston, Gill, additional, Manthorpe, Jill, additional, Hoe, Juanita, additional, Rockwood, Kenneth, additional, Howard, Robert J, additional, Butler, Laurie, additional, Orgeta, Vasiliki, additional, Walters, Kate, additional, and Cooper, Claudia, additional

Published
2023
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20. APPLE‐Tree remote secondary dementia prevention; opportunities for scalable public health interventions to reduce dementia risk

Author

Cooper, Claudia, primary, Barber, Julie, additional, Aguirre, Elisa M, additional, Whitfield, Elenyd M, additional, Parnell‐Johnson, Sukey M, additional, Martin, Wendy M, additional, Higgs, Paul, additional, Minihane, Anne‐Marie, additional, Poppe, Michaela, additional, Burton, Alexandra, additional, Marchant, Natalie L, additional, Bass, Nicholas, additional, Morgan‐Trimmer, Sarah, additional, Rapaport, Penny, additional, Kales, Helen C, additional, Huntley, Jonathan D, additional, Ritchie, Karen, additional, Hunter, Rachael M, additional, Walker, Zuzana, additional, Brodaty, Henry, additional, Lang, Iain A, additional, Petersen, Irene, additional, Rio, Miguel, additional, Wenborn, Jennifer, additional, Adeleke, Mariam M, additional, and Walters, Kate, additional

Published
2023
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22. DISTRIBUTION AND TRANSPORT OF OLYMPIA OYSTER OSTREA LURIDA LARVAE IN NORTHERN PUGET SOUND, WASHINGTON

Author

Grossman, Sarah K., Grossman, Eric E., Barber, Julie S., Gamblewood, Sanoosh K., and Crosby, Sean C.

Subjects
United States. Geological Survey -- International economic relations, Estuaries, Coastal ecosystems, Biological sciences, Zoology and wildlife conservation, Washington University
Abstract

As efforts for restoring Olympia oyster Ostrea lurida populations have expanded, there is an increased need to understand local factors that could influence the long-term success of these projects. To address concerns over potential limitations to recruitment at a restoration site in northern Puget Sound. WA, a study was developed to characterize physical processes governing larval transport in conjunction with larval abundance and environmental factors. Larval presence was not associated with tide cycle, season, or a combination of tide cycle and season. In terms of location, larvae were more likely to be present at offshore and intertidal sites versus the estuarine lagoon, where the adult population resides. Larval density was higher during late summer ebbs versus early summer floods. Across sampling dates and locations, larval sizes ranged from 184 to 263 [micro]m, indicating that larvae were released into the water column throughout the reproductive season and retained in the embayment for at least ~ 16 days. Throughout different tidal cycles in Skagit Bay, acoustic Doppler current profilers were used to measure current direction and velocities, concurrent with plankton sampling. Surface currents in the study area alternated between a clockwise and a counterclockwise gyre during initial ebb and flood tides, respectively. Larvae exported from the source population during initial to midebbs are swept into a northward gyre and potentially retained at intertidal sites alongshore. These results will provide resource managers attempting to restore native bivalves with the ability to expand populations by identifying optimal areas for habitat enhancement through natural recruitment. KEY WORDS: Ostrea lurida, nearshore circulation, Olympia oyster, larval transport, Puget Sound, recruitment, restoration, INTRODUCTION Successful restoration of marine invertebrate species with complex life cycles is often highly dependent on larval dispersal and the recruitment dynamics of the species. Sessile invertebrate populations are particularly [...]

Published
2020
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23. Clinical and cost-effectiveness of the Managing Agitation and Raising Quality of Life (MARQUE) intervention for agitation in people with dementia in care homes: a single-blind, cluster-randomised controlled trial

Author

Livingston, Gill, Barber, Julie, Marston, Louise, Stringer, Aisling, Panca, Monica, Hunter, Rachael, Cooper, Claudia, Laybourne, Anne, La Frenais, Francesca, Reeves, Suzanne, Manela, Monica, Lambe, Katie, Banerjee, Sube, and Rapaport, Penny

Published
2019
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24. Feasibility and acceptability of NIDUS-professional, a training and support intervention for homecare workers caring for clients living with dementia: a cluster-randomised feasibility trial.

Author

Cooper, Claudia, Zabihi, Sedigheh, Akhtar, Amirah, Lee, Teresa, Isaaq, Abdinasir, Novere, Marie Le, Barber, Julie, Lord, Kathryn, Rapaport, Penny, Banks, Sara, Duggan, Sandra, Ogden, Margaret, Walters, Kate, Orgeta, Vasiliki, Rockwood, Kenneth, Butler, Laurie T, Manthorpe, Jill, Dow, Briony, Hoe, Juanita, and Hunter, Rachael

Subjects
TEACHING methods, PATIENT care, DESCRIPTIVE statistics, CONFIDENCE intervals, DEMENTIA, DEMENTIA patients, MEDICAL care costs
Abstract

Introduction In the first randomised controlled trial of a dementia training and support intervention in UK homecare agencies, we aimed to assess: acceptability of our co-designed, manualised training, delivered by non-clinical facilitators; outcome completion feasibility; and costs for a future trial. Methods This cluster-randomised (2:1) single-blind, feasibility trial involved English homecare agencies. Intervention arm agency staff were offered group videocall sessions: 6 over 3 months, then monthly for 3 months (NIDUS-professional). Family carers (henceforth carers) and clients with dementia (dyads) were offered six to eight complementary, individual intervention sessions (NIDUS-Family). We collected potential trial measures as secondary outcomes remotely at baseline and 6 months: HCW (homecare worker) Work-related Strain Inventory (WRSI), Sense of Competence (SoC); proxy-rated Quality of Life (QOL), Disability Assessment for Dementia scale (DAD), Neuropsychiatric Inventory (NPI) and Homecare Satisfaction (HCS). Results From December 2021 to September 2022, we met agency (4 intervention, 2 control) and HCWs (n  = 62) recruitment targets and recruited 16 carers and 16/60 planned clients. We met a priori progression criteria for adherence (≥4/6 sessions: 29/44 [65.9%,95% confidence interval (CI): 50.1,79.5]), HCW or carer proxy-outcome completion (15/16 (93.8% [69.8,99.8]) and proceeding with adaptation for HCWs outcome completion (46/63 (73.0% [CI: 60.3,83.4]). Delivery of NIDUS-Professional costs was £6,423 (£137 per eligible client). WRSI scores decreased and SoC increased at follow-up, with no significant between-group differences. For intervention arm proxy-rated outcomes, carer-rated QOL increased, HCW-rated was unchanged; carer and HCW-rated NPI decreased; DAD decreased (greater disability) and HCS was unchanged. Conclusion A pragmatic trial is warranted; we will consider using aggregated, agency-level client outcomes, including neuropsychiatric symptoms. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Chronic Obstructive Pulmonary Disease Self-Management in Three Low- and Middle-Income Countries: A Pilot Randomized Trial

Author

Pollard, Suzanne L., primary, Siddharthan, Trishul, additional, Hossen, Shakir, additional, Rykiel, Natalie A., additional, Flores-Flores, Oscar, additional, Alupo, Patricia, additional, Quaderi, Shumonta, additional, Ascencio, Ivonne, additional, Barber, Julie A., additional, Chandyo, Ram, additional, Das, Santa K., additional, Gianella, Gonzalo, additional, Kirenga, Bruce, additional, Grunstra, Kelli, additional, Miranda, J. Jaime, additional, Mohan, Sakshi, additional, Ricciardi, Federico, additional, Sharma, Arun K., additional, Shrestha, Laxman, additional, Soares, Marta O., additional, Wosu, Adaeze C., additional, Hurst, John R., additional, Checkley, William, additional, Michie, Susan, additional, Anastasiou, Zachos, additional, Robertson, Nicole, additional, Wise, Robert A, additional, Yogi, Karbir N., additional, Mawanda, Denis, additional, Nassali, Faith, additional, Kalyesubula, Robert, additional, Romani-Huacani, Elisa, additional, and Cattamanchi, Adithya, additional

Published
2023
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26. Recruitment, growth and mortality of an Antarctic hexactinellid sponge, Anoxycalyx joubini.

Author

Dayton, Paul K, Kim, Stacy, Jarrell, Shannon C, Oliver, John S, Hammerstrom, Kamille, Fisher, Jennifer L, O'Connor, Kevin, Barber, Julie S, Robilliard, Gordon, Barry, James, Thurber, Andrew R, and Conlan, Kathy

Subjects
Animals, Porifera, Biomass, Ice Cover, Geography, Time Factors, Antarctic Regions, Oceans and Seas, General Science & Technology
Abstract

Polar ecosystems are sensitive to climate forcing, and we often lack baselines to evaluate changes. Here we report a nearly 50-year study in which a sudden shift in the population dynamics of an ecologically important, structure-forming hexactinellid sponge, Anoxycalyx joubini was observed. This is the largest Antarctic sponge, with individuals growing over two meters tall. In order to investigate life history characteristics of Antarctic marine invertebrates, artificial substrata were deployed at a number of sites in the southern portion of the Ross Sea between 1967 and 1975. Over a 22-year period, no growth or settlement was recorded for A. joubini on these substrata; however, in 2004 and 2010, A. joubini was observed to have settled and grown to large sizes on some but not all artificial substrata. This single settlement and growth event correlates with a region-wide shift in phytoplankton productivity driven by the calving of a massive iceberg. We also report almost complete mortality of large sponges followed over 40 years. Given our warming global climate, similar system-wide changes are expected in the future.

Published
2013

29. Unmet Diagnostic and Therapeutic Opportunities for Chronic Obstructive Pulmonary Disease in Low- and Middle-Income Countries

Author

Florman, Katia E.H., primary, Siddharthan, Trishul, additional, Pollard, Suzanne L., additional, Alupo, Patricia, additional, Barber, Julie A., additional, Chandyo, Ram K., additional, Flores-Flores, Oscar, additional, Kirenga, Bruce, additional, Mendes, Renata Gonçalves, additional, Miranda, J. Jaime, additional, Mohan, Sakshi, additional, Ricciardi, Federico, additional, Rykiel, Natalie A., additional, Sharma, Arun K., additional, Wosu, Adaeze C., additional, Checkley, William, additional, Hurst, John R., additional, Cárdenas, Maria Kathia, additional, Kumar Das, Santa, additional, Hossen, Shakir, additional, Kalyesubula, Robert, additional, Mawanda, Denis, additional, Nassali, Faith, additional, Quaderi, Shumonta A., additional, Robertson, Nicole, additional, Shrestha, Laxman, additional, and Yogi, Karbir N., additional

Published
2023
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31. Point‐of‐care Analysis for Non‐invasive Diagnosis of Oral cancer (PANDORA): A technology‐development proof of concept diagnostic accuracy study of dielectrophoresis in patients with oral squamous cell carcinoma and dysplasia

Author

Hughes, Michael P., primary, Labeed, Fatima H., additional, Hoettges, Kai F., additional, Porter, Stephen, additional, Mercadante, Valeria, additional, Kalavrezos, Nicholas, additional, Liew, Colin, additional, McCaul, James A., additional, Kulkarni, Raghav, additional, Cymerman, James, additional, Kerawala, Cyrus, additional, Barber, Julie, additional, Lewis, Mark P., additional, and Fedele, Stefano, additional

Published
2023
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32. LB2304. INHALE WP3: Results of a multi-centre randomised controlled trial (INHALE) testing the utility of rapid multiplex PCR at point-of-care for the antibiotic management of hospital-acquired and ventilator-associated pneumonia in critical care.

Author

Enne, Virve, primary, Stirling, Susan, additional, Barber, Julie, additional, High, Juliet, additional, Russell, Charlotte, additional, Dresser, Kerry, additional, Dhesi, Zaneeta, additional, Brealey, David, additional, Singh, Suveer, additional, Swart, Ann Marie, additional, Livermore, David, additional, and Gant, Vanya, additional

Published
2022
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33. Unmet Diagnostic and Therapeutic Opportunities for COPD in Low- and Middle-Income Countries

Author

Florman, Katia Eh, Siddharthan, Trishul, Pollard, Suzanne L., Alupo, Patricia, Barber, Julie A., Chandyo, Ram K., Flores-Flores, Oscar, Kirenga, Bruce, Mendes, Renata Gonçalves, Miranda, J. Jaime, Mohan, Sakshi, Ricciardi, Federico, Rykiel, Natalie A., Sharma, Arun K., Wosu, Adaeze C., Checkley, William, and Hurst, John R.

Subjects
LMIC, Rehabilitación, Países en Desarrollo, Enfermedad Pulmonar Obstructiva Crónica, COPD, Pulmonary Rehabilitation, Guidelines, Bronchodilator, Guías como Asunto
Abstract

RATIONALE: Chronic obstructive pulmonary disease (COPD) is a prevalent and burdensome condition in low- and middle-income countries (LMICs). Challenges to better care include more effective diagnosis, and access to affordable interventions. There are no previous reports describing therapeutic needs in LMIC populations with COPD identified through screening. OBJECTIVE: To describe unmet therapeutic need in screening-detected COPD in LMIC settings. METHODS: We compared interventions recommended by the international 'GOLD' COPD strategy document, with that received, in 1000 people with COPD identified by population screening at three LMIC sites in Nepal, Peru and Uganda. We calculated costs using data on the availability and affordability of medicines. MEASUREMENT AND MAIN RESULTS: The greatest unmet need for non-pharmacological interventions was for education and vaccinations (applicable to all), pulmonary rehabilitation (49%), smoking cessation (30%) and advice on biomass smoke exposure (26%). 95% of cases were previously undiagnosed and few were receiving therapy (4.5% had short-acting beta-agonists). Only three of 47 people (6%) with a previous COPD diagnosis had access to drugs consistent with recommendations. None of those with more severe COPD were accessing appropriate maintenance inhalers. Even when available, maintenance treatments were unaffordable with 30 days of treatment more than a low-skilled workers' daily average wage. CONCLUSION: We found significant missed opportunity to reduce the burden of COPD in LMIC settings, with most cases undiagnosed. Whilst there is unmet need in developing novel therapies, in LMICs where the burden is greatest, better diagnosis together with access to affordable interventions could translate to immediate benefit.

Published
2023

38. Low temperature brooding of Olympia oysters (Ostrea lurida) in northern Puget Sound

Author

Barber, Julie S., Dexter, Jackie E., Grossman, Sarah K., Greiner, Courtney M., and McArdle, James T.

Subjects
Crassostrea -- Growth -- Environmental aspects, Oysters -- Growth -- Environmental aspects, Company growth, Biological sciences, Zoology and wildlife conservation
Abstract

ABSTRACT Olympia oysters (Ostrea lurida) traditionally played important ecological, economic, and cultural roles as the only oyster native to the west coast of North America. Yet overfishing, pollution, and the [...]

Published
2016
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39. Process evaluation of the New Interventions for independence in\ud Dementia Study (NIDUS) Family stream randomised controlled trial: protocol

Author

Wyman, Danielle L., Butler, Laurie T., Cooper, Claudia, Bright, Peter, Morgan-Trimmer, Sarah, and Barber, Julie

Abstract

Introduction New Interventions for independence in Dementia Study (NIDUS)-Family is an Alzheimer’s Society funded new manualised, multimodal psychosocial intervention to support people living with dementia (PLWD) to achieve goals that they and their family carers set,\ud towards living as independently and as well as possible at home for longer. This process evaluation will be embedded within the NIDUS- Family Randomised Controlled Trial intervention-arm (n=199), testing how the intervention influences change, as measured by goal attainment.\ud The evaluation will test, refine and develop the NIDUS-Family theoretical model, associated causal assumptions and logic model to identify key mechanisms of impact,\ud implementation and contextual factors influencing the intervention’s effectiveness. Findings will inform how the programme is implemented in practice. \ud Methods and analysis The process evaluation will be theory driven and apply a convergent mixed-methods design. Dyads (PLWD and family carer) will be purposively sampled based on high or low Goal Attainment Scaling\ud scores (trial primary outcome). Qualitative interviews with dyads (approx. n=30) and their respective facilitators post-trial will explore their experiences of receiving and delivering the intervention. Interviews will be iteratively thematically analysed. Matching observational quantitative\ud data will be collected concurrently from videorecordings and/or audiorecordings of NIDUS-Family dyad trial sessions. Further quantitative data will be collected through an acceptability questionnaire for all intervention-arm dyads (n=199). Mixed-method integration will use\ud an interactive analysis strategy, considering qualitative and quantitative findings through mixed-method matrix for dyadic level ‘case studies’, and a joint display for ‘population’ level analysis and interpretation.

Published
2022

40. GSTM1 Copy Number and Kidney Disease in People With HIV

Author

Hung, Rachel K.Y., primary, Rosenberg, Kerry-Lee, additional, David, Victor, additional, Binns-Roemer, Elizabeth, additional, Booth, John W., additional, Hilton, Rachel, additional, Fox, Julie, additional, Burns, Fiona, additional, Ustianowski, Andrew, additional, Cosgrove, Catherine, additional, Hamzah, Lisa, additional, Burns, James E., additional, Clarke, Amanda, additional, Chadwick, David, additional, Price, David A., additional, Kegg, Stephen, additional, Campbell, Lucy, additional, Bramham, Kate, additional, Sabin, Caroline A., additional, Post, Frank A., additional, Winkler, Cheryl A., additional, Waters, Anele, additional, Hand, James, additional, Clarke, Chris, additional, Murphy, Sarah, additional, Murphy, Maurice, additional, Campbell, Marion, additional, Richardson, Celia, additional, Knott, Alyson, additional, Weir, Gemma, additional, Cleig, Rebecca, additional, Soviarova, Helena, additional, Barbour, Lisa, additional, Adams, Tanya, additional, Kennard, Vicky, additional, Trevitt, Vittorio, additional, Jones, Rachael, additional, Levy, Jeremy, additional, Schoolmeester, Alexandra, additional, Duro, Serah, additional, Rabuya, May, additional, Jordan, Deborah, additional, Solano, Teresa, additional, Uzu, Hiromi, additional, Williams, Karen, additional, Lwanga, Julianne, additional, Reid-Amoruso, Linda Ekaette, additional, Gamlen, Hannah, additional, Stocker, Robert J., additional, Ryan, Fiona, additional, Mahiouz, Karina, additional, Cheetham, Tess, additional, Williams, Claire, additional, Nori, Achyuta, additional, Thomas, Caroline, additional, Venkateshwaran, Sivaraj, additional, Doctor, Jessica, additional, Berlanga, Andrea, additional, Santana-Suarez, Beatriz, additional, McQueen, Leigh, additional, Bhagwandin, Priya, additional, Barbini, Bee, additional, Wandolo, Emily, additional, Appleby, Tim, additional, Driver, Lois, additional, Parr, Sophy, additional, Deng, Hongbo, additional, Barber, Julie, additional, Crowe, Andrew, additional, Taylor, Chris, additional, Poulton, Mary, additional, Boateng, Vida, additional, Klein, Marie-Pierre, additional, O'Brien, Caitlin, additional, Ohene-Adomako, Samuel, additional, Buckingham, Christian, additional, Trotman, Daniel, additional, Quinn, Killian, additional, Flanagan, Kate, additional, Sullivan, Verity, additional, Middleditch, Holly, additional, Samuel, Itty, additional, Hamlyn, Elizabeth, additional, McDonald, Candice, additional, Canoso, Ana, additional, Agbasi, Emeka, additional, Liskova, Maria, additional, Barber, Sarah, additional, Samarawickrama, Amanda, additional, Ottaway, Zoe, additional, Norcross, Claire, additional, Oliveira, Amelia, additional, Minton, Jane, additional, Lamont, Gary, additional, Cross, Ruby, additional, Saiyad, Gaushiya, additional, Ahmed, Shadia, additional, Ashworth, Rebecca, additional, Window, Nicola, additional, Murira, J., additional, Phyu, Khine, additional, Lindergard, Gabriella, additional, Shaw, Jonathan, additional, Holland, Sarah, additional, Fox, Claire, additional, Flaherty, Jan, additional, Bevan, Margaret-Anne, additional, George, Valerie, additional, Branch, Marie, additional, Lambert, Pauline, additional, Craggs, Adele, additional, Pett, Sarah, additional, Lukha, Hinal, additional, Vora, Nina, additional, Fiorino, Marzia, additional, Nunez, Maria Muller, additional, Sally, Deirdre, additional, Pool, Erica, additional, Matthews, Rebecca, additional, Stothard, Tara, additional, Patel, Bijal, additional, McVittie, Ian, additional, Kennedy, Ciara, additional, Shwab, Uli, additional, Payne, Brendan, additional, Duncan, Sarah, additional, Dixon, Jill, additional, Schmid, Mathias, additional, Evans, Adam, additional, Duncan, Christopher, additional, Hunter, Ewan, additional, Taha, Yusri, additional, Astill, Natasha, additional, Ainsworth, Jonathan, additional, Vincent, Rachel, additional, Saad, Chloe, additional, Skinner, Sarah, additional, Azzoug, Hocine, additional, Russell, Judith, additional, Moussaoui, Tarik, additional, Mabonga, Emily, additional, Ward, Donna, additional, Francoise, J., additional, Larbi, W., additional, Mitchell, Sue, additional, Manning, A., additional, Russell, V., additional, Harber, Mark, additional, Ngwu, Nnenna, additional, Edwards, Jonathan, additional, Hemat, Nargis, additional, Fernandez, Tom, additional, Ferro, Filippo, additional, Ferreira, Jorge, additional, Nightingale, Alice, additional, Oakes-Monger, Tasha, additional, Matila, Darwin, additional, Nogueira, Pedro, additional, Mutagwanya, Victoria, additional, Isitt, Catherine Emily, additional, Webb, Helen, additional, Popoola, Joyce, additional, Korley, Kate, additional, Mencias, Mark, additional, Ribeiro, Patricia, additional, Ramkhelawn, Rajeshwar, additional, Lara, Sandra Oliva, additional, Sajijad, Sara, additional, Winston, Alan, additional, Shaw, Amber, additional, Petersen, Claire, additional, Ring, Kyle, additional, Rosenvinge, Melanie, additional, Moyo, Thembi, additional, Odong, Faith, additional, Gantert, Katherine, additional, Ibe, Tina, additional, Onyango, Denis, additional, and Hill, Teresa, additional

Published
2022
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41. Cost-Accuracy Analysis of Chronic Obstructive Pulmonary Disease Screening in Low- and Middle-Income Countries

Author

Mohan, Sakshi, primary, Cárdenas, Maria Kathia, additional, Ricciardi, Federico, additional, Siddharthan, Trishul, additional, Pollard, Suzanne L., additional, Rykiel, Natalie A., additional, Checkley, William, additional, Hurst, John R., additional, Soares, Marta O., additional, Alupo, Patricia, additional, Barber, Julie A., additional, Kathia Cárdenas, Maria, additional, Chandyo, Ram K., additional, Das, Santa Kumar, additional, Flores-Flores, Oscar, additional, Kirenga, Bruce, additional, Jaime Miranda, J., additional, Mohan, Sakshi, additional, Quaderi, Shumonta A., additional, Sharma, Arun K., additional, Shrestha, Laxman, additional, and Wosu, Adaeze C., additional

Published
2022
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43. The APPLE Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: Randomised Controlled Trial

Author

Poppe, Michaela, primary, Duffy, Larisa, additional, Marchant, Natalie, additional, Barber, Julie, additional, Hunter, Rachael, additional, Bass, Nick, additional, Minihane, Annemarie, additional, Walters, Kate, additional, Higgs, Paul, additional, Rapaport, Penny, additional, Lang, Iain, additional, Morgan-Trimmer, Sarah, additional, Huntley, Jonathan, additional, Walker, Zuzana, additional, Brodaty, Henry, additional, Kales, Helen, additional, Ritchie, Karen, additional, Burton, Alexandra, additional, Wenborn, Jennifer, additional, Betz, Anna, additional, and Cooper, Claudia, additional

Published
2022
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44. GSTM1 Copy Number and Kidney Disease in People With HIV

Author

Waters, Anele, Hand, James, Clarke, Chris, Murphy, Sarah, Murphy, Maurice, Campbell, Marion, Richardson, Celia, Knott, Alyson, Weir, Gemma, Cleig, Rebecca, Soviarova, Helena, Barbour, Lisa, Adams, Tanya, Kennard, Vicky, Trevitt, Vittorio, Jones, Rachael, Levy, Jeremy, Schoolmeester, Alexandra, Duro, Serah, Rabuya, May, Jordan, Deborah, Solano, Teresa, Uzu, Hiromi, Williams, Karen, Lwanga, Julianne, Reid-Amoruso, Linda Ekaette, Gamlen, Hannah, Stocker, Robert J., Ryan, Fiona, Mahiouz, Karina, Cheetham, Tess, Williams, Claire, Nori, Achyuta, Thomas, Caroline, Venkateshwaran, Sivaraj, Doctor, Jessica, Berlanga, Andrea, Santana-Suarez, Beatriz, McQueen, Leigh, Bhagwandin, Priya, Barbini, Bee, Wandolo, Emily, Appleby, Tim, Driver, Lois, Parr, Sophy, Deng, Hongbo, Barber, Julie, Crowe, Andrew, Taylor, Chris, Poulton, Mary, Boateng, Vida, Klein, Marie-Pierre, O'Brien, Caitlin, Ohene-Adomako, Samuel, Buckingham, Christian, Trotman, Daniel, Quinn, Killian, Flanagan, Kate, Sullivan, Verity, Middleditch, Holly, Samuel, Itty, Hamlyn, Elizabeth, McDonald, Candice, Canoso, Ana, Agbasi, Emeka, Liskova, Maria, Barber, Sarah, Samarawickrama, Amanda, Ottaway, Zoe, Norcross, Claire, Oliveira, Amelia, Minton, Jane, Lamont, Gary, Cross, Ruby, Saiyad, Gaushiya, Ahmed, Shadia, Ashworth, Rebecca, Window, Nicola, Murira, J., Phyu, Khine, Lindergard, Gabriella, Shaw, Jonathan, Holland, Sarah, Fox, Claire, Flaherty, Jan, Bevan, Margaret-Anne, George, Valerie, Branch, Marie, Lambert, Pauline, Craggs, Adele, Pett, Sarah, Lukha, Hinal, Vora, Nina, Fiorino, Marzia, Nunez, Maria Muller, Sally, Deirdre, Pool, Erica, Matthews, Rebecca, Stothard, Tara, Patel, Bijal, McVittie, Ian, Kennedy, Ciara, Shwab, Uli, Payne, Brendan, Duncan, Sarah, Dixon, Jill, Schmid, Mathias, Evans, Adam, Duncan, Christopher, Hunter, Ewan, Taha, Yusri, Astill, Natasha, Ainsworth, Jonathan, Vincent, Rachel, Saad, Chloe, Skinner, Sarah, Azzoug, Hocine, Russell, Judith, Moussaoui, Tarik, Mabonga, Emily, Ward, Donna, Francoise, J., Larbi, W., Mitchell, Sue, Manning, A., Russell, V., Harber, Mark, Ngwu, Nnenna, Edwards, Jonathan, Hemat, Nargis, Fernandez, Tom, Ferro, Filippo, Ferreira, Jorge, Nightingale, Alice, Oakes-Monger, Tasha, Matila, Darwin, Nogueira, Pedro, Mutagwanya, Victoria, Isitt, Catherine Emily, Webb, Helen, Popoola, Joyce, Korley, Kate, Mencias, Mark, Ribeiro, Patricia, Ramkhelawn, Rajeshwar, Lara, Sandra Oliva, Sajijad, Sara, Winston, Alan, Shaw, Amber, Petersen, Claire, Ring, Kyle, Rosenvinge, Melanie, Moyo, Thembi, Odong, Faith, Gantert, Katherine, Ibe, Tina, Onyango, Denis, Hill, Teresa, Hung, Rachel K.Y., Rosenberg, Kerry-Lee, David, Victor, Binns-Roemer, Elizabeth, Booth, John W., Hilton, Rachel, Fox, Julie, Burns, Fiona, Ustianowski, Andrew, Cosgrove, Catherine, Hamzah, Lisa, Burns, James E., Clarke, Amanda, Chadwick, David, Price, David A., Kegg, Stephen, Campbell, Lucy, Bramham, Kate, Sabin, Caroline A., Post, Frank A., and Winkler, Cheryl A.

Published
2022
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47. Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV

Author

Hung, Rachel K.Y., primary, Binns-Roemer, Elizabeth, additional, Booth, John W., additional, Hilton, Rachel, additional, Harber, Mark, additional, Santana-Suarez, Beatriz, additional, Campbell, Lucy, additional, Fox, Julie, additional, Ustianowski, Andrew, additional, Cosgrove, Catherine, additional, Burns, James E., additional, Clarke, Amanda, additional, Price, David A., additional, Chadwick, David, additional, Onyango, Denis, additional, Hamzah, Lisa, additional, Bramham, Kate, additional, Sabin, Caroline A., additional, Winkler, Cheryl A., additional, Post, Frank A., additional, Booth, John, additional, Waters, Anele, additional, Hand, James, additional, Clarke, Chris, additional, Murphy, Sarah, additional, Murphy, Maurice, additional, Campbell, Marion, additional, Richardson, Celia, additional, Knott, Alyson, additional, Weir, Gemma, additional, Cleig, Rebecca, additional, Soviarova, Helena, additional, Barbour, Lisa, additional, Adams, Tanya, additional, Kennard, Vicky, additional, Trevitt, Vittorio, additional, Jones, Rachael, additional, Levy, Jeremy, additional, Schoolmeester, Alexandra, additional, Duro, Serah, additional, Rabuya, May, additional, Jordan, Deborah, additional, Solano, Teresa, additional, Uzu, Hiromi, additional, Williams, Karen, additional, Lwanga, Julianne, additional, Reid-Amoruso, Linda Ekaette, additional, Gamlen, Hannah, additional, Stocker, Robert J., additional, Ryan, Fiona, additional, Mahiouz, Karina, additional, Cheetham, Tess, additional, Williams, Claire, additional, Nori, Achyuta, additional, Thomas, Caroline, additional, Venkateshwaran, Sivaraj, additional, Doctor, Jessica, additional, Berlanga, Andrea, additional, Post, Frank, additional, McQueen, Leigh, additional, Bhagwandin, Priya, additional, Barbini, Bee, additional, Wandolo, Emily, additional, Appleby, Tim, additional, Driver, Lois, additional, Parr, Sophy, additional, Deng, Hongbo, additional, Barber, Julie, additional, Crowe, Andrew, additional, Taylor, Chris, additional, Poulton, Mary, additional, Boateng, Vida, additional, Klein, Marie-Pierre, additional, O'Brien, Caitlin, additional, Ohene-Adomako, Samuel, additional, Buckingham, Christian, additional, Trotman, Daniel, additional, Quinn, Killian, additional, Flanagan, Kate, additional, Sullivan, Verity, additional, Middleditch, Holly, additional, Samuel, Itty, additional, Hamlyn, Elizabeth, additional, McDonald, Candice, additional, Canoso, Ana, additional, Agbasi, Emeka, additional, Liskova, Maria, additional, Barber, Sarah, additional, Samarawickrama, Amanda, additional, Ottaway, Zoe, additional, Norcross, Claire, additional, Oliveira, Amelia, additional, Minton, Jane, additional, Lamont, Gary, additional, Cross, Ruby, additional, Saiyad, Gaushiya, additional, Ahmed, Shadia, additional, Ashworth, Rebecca, additional, Window, Nicola, additional, Murira, J., additional, Phyu, Khine, additional, Lindergard, Gabriella, additional, Shaw, Jonathan, additional, Holland, Sarah, additional, Fox, Claire, additional, Flaherty, Jan, additional, Bevan, Margaret-Anne, additional, George, Valerie, additional, Branch, Marie, additional, Lambert, Pauline, additional, Craggs, Adele, additional, Pett, Sarah, additional, Lukha, Hinal, additional, Vora, Nina, additional, Fiorino, Marzia, additional, Nunez, Maria Muller, additional, Sally, Deirdre, additional, Pool, Erica, additional, Matthews, Rebecca, additional, Price, David Ashley, additional, Stothard, Tara, additional, Patel, Bijal, additional, McVittie, Ian, additional, Kennedy, Ciara, additional, Shwab, Uli, additional, Payne, Brendan, additional, Duncan, Sarah, additional, Dixon, Jill, additional, Schmid, Mathias, additional, Evans, Adam, additional, Duncan, Christopher, additional, Hunter, Ewan, additional, Taha, Yusri, additional, Astill, Natasha, additional, Winkler, Cheryl, additional, David, Victor, additional, Ainsworth, Jonathan, additional, Vincent, Rachel, additional, Kegg, Stephen, additional, Saad, Chloe, additional, Skinner, Sarah, additional, Azzoug, Hocine, additional, Russell, Judith, additional, Moussaoui, Tarik, additional, Mabonga, Emily, additional, Ward, Donna, additional, Francoise, J., additional, Larbi, W., additional, Mitchell, Sue, additional, Manning, A., additional, Russell, V., additional, Burns, Fiona, additional, Ngwu, Nnenna, additional, Edwards, Jonathan, additional, Hemat, Nargis, additional, Fernandez, Tom, additional, Ferro, Filippo, additional, Ferreira, Jorge, additional, Nightingale, Alice, additional, Oakes-Monger, Tasha, additional, Matila, Darwin, additional, Nogueira, Pedro, additional, Mutagwanya, Victoria, additional, Isitt, Catherine Emily, additional, Webb, Helen, additional, Popoola, Joyce, additional, Korley, Kate, additional, Mencias, Mark, additional, Ribeiro, Patricia, additional, Ramkhelawn, Rajeshwar, additional, Lara, Sandra Oliva, additional, Sajijad, Sara, additional, Winston, Alan, additional, Shaw, Amber, additional, Petersen, Claire, additional, Ring, Kyle, additional, Rosenvinge, Melanie, additional, Moyo, Thembi, additional, Odong, Faith, additional, Gantert, Katherine, additional, Ibe, Tina, additional, Sabin, Caroline, additional, and Hill, Teresa, additional

Published
2022
Full Text
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48. Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV

Author

Hung, Rachel K.Y., primary, Binns-Roemer, Elizabeth, additional, Booth, John W., additional, Hilton, Rachel, additional, Fox, Julie, additional, Burns, Fiona, additional, Harber, Mark, additional, Ustianowski, Andrew, additional, Hamzah, Lisa, additional, Burns, James E., additional, Clarke, Amanda, additional, Price, David A., additional, Kegg, Stephen, additional, Onyango, Denis, additional, Santana-Suarez, Beatriz, additional, Campbell, Lucy, additional, Bramham, Kate, additional, Sharpe, Claire C., additional, Sabin, Caroline A., additional, Winkler, Cheryl A., additional, Post, Frank A., additional, Booth, John, additional, Waters, Anele, additional, Hand, James, additional, Clarke, Chris, additional, Murphy, Sarah, additional, Murphy, Maurice, additional, Campbell, Marion, additional, Richardson, Celia, additional, Knott, Alyson, additional, Weir, Gemma, additional, Cleig, Rebecca, additional, Soviarova, Helena, additional, Barbour, Lisa, additional, Adams, Tanya, additional, Kennard, Vicky, additional, Trevitt, Vittorio, additional, Jones, Rachael, additional, Levy, Jeremy, additional, Schoolmeester, Alexandra, additional, Duro, Serah, additional, Rabuya, May, additional, Jordan, Deborah, additional, Solano, Teresa, additional, Uzu, Hiromi, additional, Williams, Karen, additional, Lwanga, Julianne, additional, Reid-Amoruso, Linda Ekaette, additional, Gamlen, Hannah, additional, Stocker, Robert J., additional, Ryan, Fiona, additional, Mahiouz, Karina, additional, Cheetham, Tess, additional, Williams, Claire, additional, Nori, Achyuta, additional, Thomas, Caroline, additional, Venkateshwaran, Sivaraj, additional, Doctor, Jessica, additional, Berlanga, Andrea, additional, Post, Frank, additional, McQueen, Leigh, additional, Bhagwandin, Priya, additional, Barbini, Bee, additional, Wandolo, Emily, additional, Appleby, Tim, additional, Driver, Lois, additional, Parr, Sophy, additional, Deng, Hongbo, additional, Barber, Julie, additional, Crowe, Andrew, additional, Taylor, Chris, additional, Poulton, Mary, additional, Boateng, Vida, additional, Klein, Marie-Pierre, additional, O’Brien, Caitlin, additional, Ohene-Adomako, Samuel, additional, Buckingham, Christian, additional, Trotman, Daniel, additional, Quinn, Killian, additional, Flanagan, Kate, additional, Sullivan, Verity, additional, Middleditch, Holly, additional, Samuel, Itty, additional, Hamlyn, Elizabeth, additional, McDonald, Candice, additional, Canoso, Ana, additional, Agbasi, Emeka, additional, Liskova, Maria, additional, Barber, Sarah, additional, Samarawickrama, Amanda, additional, Ottaway, Zoe, additional, Norcross, Claire, additional, Oliveira, Amelia, additional, Minton, Jane, additional, Lamont, Gary, additional, Cross, Ruby, additional, Saiyad, Gaushiya, additional, Ahmed, Shadia, additional, Ashworth, Rebecca, additional, Window, Nicola, additional, Murira, J., additional, Phyu, Khine, additional, Lindergard, Gabriella, additional, Shaw, Jonathan, additional, Holland, Sarah, additional, Fox, Claire, additional, Flaherty, Jan, additional, Bevan, Margaret-Anne, additional, George, Valerie, additional, Chadwick, David, additional, Branch, Marie, additional, Lambert, Pauline, additional, Craggs, Adele, additional, Pett, Sarah, additional, Lukha, Hinal, additional, Vora, Nina, additional, Fiorino, Marzia, additional, Nunez, Maria Muller, additional, Sally, Deirdre, additional, Pool, Erica, additional, Matthews, Rebecca, additional, Price, David Ashley, additional, Stothard, Tara, additional, Patel, Bijal, additional, McVittie, Ian, additional, Kennedy, Ciara, additional, Shwab, Uli, additional, Payne, Brendan, additional, Duncan, Sarah, additional, Dixon, Jill, additional, Schmid, Mathias, additional, Evans, Adam, additional, Duncan, Christopher, additional, Hunter, Ewan, additional, Taha, Yusri, additional, Astill, Natasha, additional, Winkler, Cheryl, additional, David, Victor, additional, Ainsworth, Jonathan, additional, Vincent, Rachel, additional, Saad, Chloe, additional, Skinner, Sarah, additional, Azzoug, Hocine, additional, Russell, Judith, additional, Moussaoui, Tarik, additional, Mabonga, Emily, additional, Ward, Donna, additional, Francoise, J., additional, Larbi, W., additional, Mitchell, Sue, additional, Manning, A., additional, Russell, V., additional, Ngwu, Nnenna, additional, Edwards, Jonathan, additional, Hemat, Nargis, additional, Fernandez, Tom, additional, Ferro, Filippo, additional, Ferreira, Jorge, additional, Nightingale, Alice, additional, Oakes-Monger, Tasha, additional, Matila, Darwin, additional, Nogueira, Pedro, additional, Mutagwanya, Victoria, additional, Cosgrove, Catherine, additional, Isitt, Catherine Emily, additional, Webb, Helen, additional, Popoola, Joyce, additional, Korley, Kate, additional, Mencias, Mark, additional, Ribeiro, Patricia, additional, Ramkhelawn, Rajeshwar, additional, Lara, Sandra Oliva, additional, Sajijad, Sara, additional, Winston, Alan, additional, Shaw, Amber, additional, Petersen, Claire, additional, Ring, Kyle, additional, Rosenvinge, Melanie, additional, Moyo, Thembi, additional, Odong, Faith, additional, Gantert, Katherine, additional, Ibe, Tina, additional, Sabin, Caroline, additional, and Hill, Teresa, additional

Published
2022
Full Text
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49. Multicentre evaluation of two multiplex PCR platforms for the rapid microbiologicalinvestigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study

Author

Enne, Virve I, Aydin, Alp, Baldan, Rossella, Owen, Dewi R, Richardson, Hollian, Ricciardi, Federico, Russell, Charlotte, Nomamiukor-Ikeji, Brenda O., Swart, Ann Marie, High, Juliet, Colles, Antony, Barber, Julie A, Gant, Vanya, Livermore, David M, O’Grady, Justin, and Morton, Ben

Subjects
qy_4, qw_4, wc_202, wf_20
Abstract

Background \ud Culture-based microbiological investigation of hospital-acquired or ventilator-associated pneumonia (HAP or VAP) is insensitive, with aetiological agents often unidentified. This can lead to excess antimicrobial treatment of patients with susceptible pathogens, while those with resistant bacteria are treated inadequately for prolonged periods. Using PCR to seek pathogens and their resistance genes directly from clinical samples may improve therapy and stewardship.\ud \ud Methods \ud Surplus routine lower respiratory tract samples were collected from intensive care unit patients about to receive new or changed antibiotics for hospital-onset lower respiratory tract infections at 15 UK hospitals. Testing was performed using the BioFire FilmArray Pneumonia Panel (bioMérieux) and Unyvero Pneumonia Panel (Curetis). Concordance analysis compared machine and routine microbiology results, while Bayesian latent class (BLC) analysis estimated the sensitivity and specificity of each test, incorporating information from both PCR panels and routine microbiology.\ud \ud Findings \ud In 652 eligible samples; PCR identified pathogens in considerably more samples compared with routine microbiology: 60.4% and 74.2% for Unyvero and FilmArray respectively vs 44.2% by routine microbiology. PCR tests also detected more pathogens per sample than routine microbiology. For common HAP/VAP pathogens, FilmArray had sensitivity of 91.7%–100.0% and specificity of 87.5%–99.5%; Unyvero had sensitivity of 50.0%–100.0%%, and specificity of 89.4%–99.0%. BLC analysis indicated that, compared with PCR, routine microbiology had low sensitivity, ranging from 27.0% to 69.4%.\ud \ud Interpretation \ud Conventional and BLC analysis demonstrated that both platforms performed similarly and were considerably more sensitive than routine microbiology, detecting potential pathogens in patient samples reported as culture negative. The increased sensitivity of detection realised by PCR offers potential for improved antimicrobial prescribing.

Published
2022

50. Time to reflect is a rare and valued opportunity; a pilot of the NIDUS‐professional dementia training intervention for homecare workers during the Covid‐19 pandemic

Author

Kelleher, Daniel, primary, Lord, Kathryn, additional, Duffy, Larisa, additional, Rapaport, Penny, additional, Barber, Julie, additional, Manthorpe, Jill, additional, Leverton, Monica, additional, Dow, Briony, additional, Budgett, Jessica, additional, Banks, Sara, additional, Duggan, Sandra, additional, and Cooper, Claudia, additional

Published
2022
Full Text
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