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1. The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Author

Raule, Nicola, Sevini, Federica, Li, Shengting, Barbieri, Annalaura, Tallaro, Federica, Lomartire, Laura, Vianello, Dario, Montesanto, Alberto, Moilanen, Jukka S., Bezrukov, Vladyslav, Blanché, Hélène, Hervonen, Antti, Christensen, Kaare, Deiana, Luca, Gonos, Efstathios S., Kirkwood, Tom B. L., Kristensen, Peter, Leon, Alberta, Pelicci, Pier Giuseppe, Poulain, Michel, Rea, Irene M., Remacle, Josè, Robine, Jean Marie, Schreiber, Stefan, Sikora, Ewa, Slagboom, Peternella Eline, Spazzafumo, Liana, Stazi, Maria Antonietta, Toussaint, Olivier, Vaupel, James W., Rose, Giuseppina, Majamaa, Kari, Perola, Markus, Johnson, Thomas E., Bolund, Lars, Yang, Huanming, Passarino, Giuseppe, and Franceschi, Claudio

Published
2014
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3. Correction: Analysis of Population Substructure in Two Sympatric Populations of Gran Chaco, Argentina

Author

Sevini, Federica, primary, Yao, Daniele Yang, additional, Lomartire, Laura, additional, Barbieri, Annalaura, additional, Vianello, Dario, additional, Ferri, Gianmarco, additional, Moretti, Edgardo, additional, Dasso, Maria Cristina, additional, Garagnani, Paolo, additional, Pettener, Davide, additional, Franceschi, Claudio, additional, Luiselli, Donata, additional, and Franceschi, Zelda Alice, additional

Published
2014
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4. The co‐occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Author

Raule, Nicola, primary, Sevini, Federica, additional, Li, Shengting, additional, Barbieri, Annalaura, additional, Tallaro, Federica, additional, Lomartire, Laura, additional, Vianello, Dario, additional, Montesanto, Alberto, additional, Moilanen, Jukka S., additional, Bezrukov, Vladyslav, additional, Blanché, Hélène, additional, Hervonen, Antti, additional, Christensen, Kaare, additional, Deiana, Luca, additional, Gonos, Efstathios S., additional, Kirkwood, Tom B. L., additional, Kristensen, Peter, additional, Leon, Alberta, additional, Pelicci, Pier Giuseppe, additional, Poulain, Michel, additional, Rea, Irene M., additional, Remacle, Josè, additional, Robine, Jean Marie, additional, Schreiber, Stefan, additional, Sikora, Ewa, additional, Eline Slagboom, Peternella, additional, Spazzafumo, Liana, additional, Antonietta Stazi, Maria, additional, Toussaint, Olivier, additional, Vaupel, James W., additional, Rose, Giuseppina, additional, Majamaa, Kari, additional, Perola, Markus, additional, Johnson, Thomas E., additional, Bolund, Lars, additional, Yang, Huanming, additional, Passarino, Giuseppe, additional, and Franceschi, Claudio, additional

Published
2013
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5. Analysis of Population Substructure in Two Sympatric Populations of Gran Chaco, Argentina

Author

Sevini, Federica, primary, Yao, Daniele Yang, additional, Lomartire, Laura, additional, Barbieri, Annalaura, additional, Vianello, Dario, additional, Ferri, Gianmarco, additional, Moretti, Edgardo, additional, Dasso, Maria Cristina, additional, Garagnani, Paolo, additional, Pettener, Davide, additional, Franceschi, Claudio, additional, Luiselli, Donata, additional, and Franceschi, Zelda Alice, additional

Published
2013
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6. Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

Author

Salvioli, Stefano, primary, Monti, Daniela, additional, Lanzarini, Catia, additional, Conte, Maria, additional, Pirazzini, Chiara, additional, Giulia Bacalini, Maria, additional, Garagnani, Paolo, additional, Giuliani, Cristina, additional, Fontanesi, Elisa, additional, Ostan, Rita, additional, Bucci, Laura, additional, Sevini, Federica, additional, Lukas Yani, Stella, additional, Barbieri, Annalaura, additional, Lomartire, Laura, additional, Borelli, Vincenzo, additional, Vianello, Dario, additional, Bellavista, Elena, additional, Martucci, Morena, additional, Cevenini, Elisa, additional, Pini, Elisa, additional, Scurti, Maria, additional, Biondi, Fiammetta, additional, Santoro, Aurelia, additional, Capri, Miriam, additional, and Franceschi, Claudio, additional

Published
2013
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7. The co-occurrence of mt DNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific.

Author

Raule, Nicola, Sevini, Federica, Li, Shengting, Barbieri, Annalaura, Tallaro, Federica, Lomartire, Laura, Vianello, Dario, Montesanto, Alberto, Moilanen, Jukka S., Bezrukov, Vladyslav, Blanché, Hélène, Hervonen, Antti, Christensen, Kaare, Deiana, Luca, Gonos, Efstathios S., Kirkwood, Tom B. L., Kristensen, Peter, Leon, Alberta, Pelicci, Pier Giuseppe, and Poulain, Michel

Subjects
MITOCHONDRIAL DNA, GENETIC mutation, OXIDATIVE phosphorylation, LONGEVITY, NUCLEOTIDE sequence, CONTROL groups
Abstract

To re-examine the correlation between mt DNA variability and longevity, we examined mt DNAs from samples obtained from over 2200 ultranonagenarians (and an equal number of controls) collected within the framework of the GEHA EU project. The samples were categorized by high-resolution classification, while about 1300 mt DNA molecules (650 ultranonagenarians and an equal number of controls) were completely sequenced. Sequences, unlike standard haplogroup analysis, made possible to evaluate for the first time the cumulative effects of specific, concomitant mt DNA mutations, including those that per se have a low, or very low, impact. In particular, the analysis of the mutations occurring in different OXPHOS complex showed a complex scenario with a different mutation burden in 90+ subjects with respect to controls. These findings suggested that mutations in subunits of the OXPHOS complex I had a beneficial effect on longevity, while the simultaneous presence of mutations in complex I and III (which also occurs in J subhaplogroups involved in LHON) and in complex I and V seemed to be detrimental, likely explaining previous contradictory results. On the whole, our study, which goes beyond haplogroup analysis, suggests that mitochondrial DNA variation does affect human longevity, but its effect is heavily influenced by the interaction between mutations concomitantly occurring on different mt DNA genes. [ABSTRACT FROM AUTHOR]

Published
2014
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