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3. Capturing sequence diversity in metagenomes with comprehensive and scalable probe design

Author

Metsky, Hayden C., Siddle, Katherine J., Gladden-Young, Adrianne, Qu, James, Yang, David K., Brehio, Patrick, Goldfarb, Andrew, Piantadosi, Anne, Wohl, Shirlee, Carter, Amber, Lin, Aaron E., Barnes, Kayla G., Tully, Damien C., Corleis, Bjӧrn, Hennigan, Scott, Barbosa-Lima, Giselle, Vieira, Yasmine R., Paul, Lauren M., Tan, Amanda L., Garcia, Kimberly F., Parham, Leda A., Odia, Ikponmwosa, Eromon, Philomena, Folarin, Onikepe A., Goba, Augustine, Simon-Lorière, Etienne, Hensley, Lisa, Balmaseda, Angel, Harris, Eva, Kwon, Douglas S., Allen, Todd M., Runstadler, Jonathan A., Smole, Sandra, Bozza, Fernando A., Souza, Thiago M. L., Isern, Sharon, Michael, Scott F., Lorenzana, Ivette, Gehrke, Lee, Bosch, Irene, Ebel, Gregory, Grant, Donald S., Happi, Christian T., Park, Daniel J., Gnirke, Andreas, Sabeti, Pardis C., and Matranga, Christian B.

Published
2019
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5. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum

Author

Bosch, Irene, de Puig, Helena, Hiley, Megan, Carré-Camps, Marc, Perdomo-Celis, Federico, Narváez, Carlos F., Salgado, Doris M., Senthoor, Dewahar, O’Grady, Madeline, Phillips, Elizabeth, Durbin, Ann, Fandos, Diana, Miyazaki, Hikaru, Yen, Chun-Wan, Gélvez-Ramírez, Margarita, Warke, Rajas V., Ribeiro, Lucas S., Teixeira, Mauro M., Almeida, Roque P., Muñóz-Medina, José E., Ludert, Juan E., Nogueira, Mauricio L., Colombo, Tatiana E., Terzian, Ana C. B., Bozza, Patricia T., Calheiros, Andrea S., Vieira, Yasmine R., Barbosa-Lima, Giselle, Vizzoni, Alexandre, Cerbino-Neto, José, Bozza, Fernando A., Souza, Thiago M. L., Trugilho, Monique R. O., de Filippis, Ana M. B., de Sequeira, Patricia C., Marques, Ernesto T. A., Magalhaes, Tereza, Díaz, Francisco J., Restrepo, Berta N., Marín, Katerine, Mattar, Salim, Olson, Daniel, Asturias, Edwin J., Lucera, Mark, Singla, Mohit, Medigeshi, Guruprasad R., de Bosch, Norma, Tam, Justina, Gómez-Márquez, Jose, Clavet, Charles, Villar, Luis, Hamad-Schifferli, Kimberly, and Gehrke, Lee

Published
2017
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6. Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection

Author

Souza, Thiago Moreno L., Vieira, Yasmine Rangel, Delatorre, Edson, Barbosa-Lima, Giselle, Luiz, Raul Leal Faria, Vizzoni, Alexandre, Jain, Komal, Miranda, Milene Mesquita, Bhuva, Nishit, Gogarten, Jan F., Ng, James, Thakkar, Riddhi, Calheiros, Andrea Surrage, Monteiro, Ana Paula Teixeira, Bozza, Patrícia T., Bozza, Fernando A., Tschoeke, Diogo A., Leomil, Luciana, Mendonça, Marcos Cesar Lima de, Rodrigues, Cintia Damasceno dos Santos, Torres, Maria C., Filippis, Ana Maria Bispo de, Nogueira, Rita Maria Ribeiro, Thompson, Fabiano L., Lemos, Cristina, Durovni, Betina, Cerbino-Neto, José, Morel, Carlos M., Lipkin, W. Ian, and Mishra, Nischay

Published
2019
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7. Dengue induces iNOS expression and nitric oxide synthesis in platelets through IL-1R.

Author

Mendonça Pinheiro, Mariana Brandi, Vicente Rozini, Stephane, Cecíllia Quirino-Teixeira, Anna, Barbosa-Lima, Giselle, Lopes, Juliana F., Sacramento, Carolina Q., Bozza, Fernando A., Bozza, Patrícia T., and Hottz, Eugenio D.

Subjects
NITRIC oxide, DENGUE, BLOOD platelets, HEMORRHAGIC fever, DENGUE viruses, PLATELET aggregation inhibitors
Abstract

Introduction: Dengue is an arthropod-born disease caused by dengue virus (DENV), that may manifest as a mild illness or severe form, characterized by hemorrhagic fever and shock. Nitric oxide (NO) is a vasodilator signaling molecule and an inhibitor of platelet aggregation known to be increased in platelets from dengue patients. However, the mechanisms underlying NO synthesis by platelets during dengue are not yet elucidated. IL-1β is a proinflammatory cytokine able to induce iNOS expression in leukocytes and present in dengue patients at high levels. Nevertheless, the role of IL-1β in platelet activation, especially regarding iNOS expression, are not clear. Methods: We prospectively followed a cohort of 28 dengue-infected patients to study NO synthesis in platelets and its relationship with disease outcomes. We used in vitro infection and stimulation models to gain insights on the mechanisms. Results and Discussion: We confirmed that platelets from dengue patients express iNOS and produce higher levels of NO during the acute phase compared to healthy volunteers, returning to normal levels after recovery. Platelet NO production during acute dengue infection was associated with the presence of warning signs, hypoalbuminemia and hemorrhagic manifestations, suggesting a role in dengue pathophysiology. By investigating the mechanisms, we evidenced increased iNOS expression in platelets stimulated with dengue patients' plasma, indicating induction by circulating inflammatory mediators. We then investigated possible factors able to induce platelet iNOS expression and observed higher levels of IL-1β in plasma from patients with dengue, which were correlated with NO production by platelets. Since platelets can synthesize and respond to IL-1β, we investigated whether IL-1β induces iNOS expression and NO synthesis in platelets. We observed that recombinant human IL-1β enhanced iNOS expression and dose-dependently increased NO synthesis by platelets. Finally, platelet infection with DENV in vitro induced iNOS expression and NO production, besides the secretion of both IL-1a and IL-1β. Importantly, treatment with IL-1 receptor antagonist or a combination of anti-IL-1α and anti-IL-1β antibodies prevented DENV-induced iNOS expression and NO synthesis. Our data show that DENV induces iNOS expression and NO production in platelets through mechanisms depending on IL-1 receptor signaling. [ABSTRACT FROM AUTHOR]

Published
2022
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8. Zika virus evolution and spread in the Americas

Author

Metsky, Hayden C., Matranga, Christian B., Wohl, Shirlee, Schaffner, Stephen F., Freije, Catherine A., Winnicki, Sarah M., West, Kendra, Qu, James, Baniecki, Mary Lynn, Gladden-Young, Adrianne, Lin, Aaron E., Tomkins-Tinch, Christopher H., Ye, Simon H., Park, Daniel J., Luo, Cynthia Y., Barnes, Kayla G., Shah, Rickey R., Chak, Bridget, Barbosa-Lima, Giselle, Delatorre, Edson, Vieira, Yasmine R., Paul, Lauren M., Tan, Amanda L., Barcellona, Carolyn M., Porcelli, Mario C., Vasquez, Chalmers, Cannons, Andrew C., Cone, Marshall R., Hogan, Kelly N., Kopp, Edgar W., Anzinger, Joshua J., Garcia, Kimberly F., Parham, Leda A., Ramrez, Rosa M. Glvez, Montoya, Maria C. Miranda, Rojas, Diana P., Brown, Catherine M., Hennigan, Scott, Sabina, Brandon, Scotland, Sarah, Gangavarapu, Karthik, Grubaugh, Nathan D., Oliveira, Glenn, Robles-Sikisaka, Refugio, Rambaut, Andrew, Gehrke, Lee, Smole, Sandra, Halloran, M. Elizabeth, Villar, Luis, Mattar, Salim, Lorenzana, Ivette, Cerbino-Neto, Jose, Valim, Clarissa, Degrave, Wim, Bozza, Patricia T., Gnirke, Andreas, Andersen, Kristian G., Isern, Sharon, Michael, Scott F., Bozza, Fernando A., Souza, Thiago M. L., Bosch, Irene, Yozwiak, Nathan L., MacInnis, Bronwyn L., and Sabeti, Pardis C.

Subjects
America -- Health aspects, Distribution, Natural history, Health aspects, Company distribution practices, Zika virus -- Natural history, Zika virus infection -- Distribution
Abstract

Author(s): Hayden C. Metsky [1, 2]; Christian B. Matranga [1]; Shirlee Wohl [1, 3]; Stephen F. Schaffner [1, 3, 4]; Catherine A. Freije [1, 3]; Sarah M. Winnicki [1]; Kendra [...]

Published
2017
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11. Corrigendum: The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication

Author

Sacramento, Carolina Q., de Melo, Gabrielle R., de Freitas, Caroline S., Rocha, Natasha, Hoelz, Lucas Villas Bôas, Miranda, Milene, Fintelman-Rodrigues, Natalia, Marttorelli, Andressa, Ferreira, André C., Barbosa-Lima, Giselle, Abrantes, Juliana L., Vieira, Yasmine Rangel, Bastos, Mônica M., Volotão, Eduardo de Mello, Nunes, Estevão Portela, Tschoeke, Diogo A., Leomil, Luciana, Loiola, Erick Correia, Trindade, Pablo, Rehen, Stevens K., Bozza, Fernando A., Bozza, Patrícia T., Boechat, Nubia, Thompson, Fabiano L., de Filippis, Ana M. B., Brüning, Karin, and Souza, Thiago Moreno L.

Subjects
Cell Survival, Zika Virus Infection, viruses, DNA-Directed RNA Polymerases, Genome, Viral, Zika Virus, Virus Replication, Corrigenda, Antiviral Agents, Article, Cell Line, Viral Proteins, Mutation, Humans, Sofosbuvir
Abstract

Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes neurological disorders during fetal development and in adulthood, antiviral drugs are necessary. Sofosbuvir is clinically approved for use against HCV and targets the protein that is most conserved among the members of the Flaviviridae family, the viral RNA polymerase. Indeed, we found that sofosbuvir inhibits ZIKV RNA polymerase, targeting conserved amino acid residues. Sofosbuvir inhibited ZIKV replication in different cellular systems, such as hepatoma (Huh-7) cells, neuroblastoma (SH-Sy5y) cells, neural stem cells (NSC) and brain organoids. In addition to the direct inhibition of the viral RNA polymerase, we observed that sofosbuvir also induced an increase in A-to-G mutations in the viral genome. Together, our data highlight a potential secondary use of sofosbuvir, an anti-HCV drug, against ZIKV.

Published
2017

12. Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication

Author

Ferreira, André C., primary, Reis, Patrícia A., additional, de Freitas, Caroline S., additional, Sacramento, Carolina Q., additional, Villas Bôas Hoelz, Lucas, additional, Bastos, Mônica M., additional, Mattos, Mayara, additional, Rocha, Natasha, additional, Gomes de Azevedo Quintanilha, Isaclaudia, additional, da Silva Gouveia Pedrosa, Carolina, additional, Rocha Quintino Souza, Leticia, additional, Correia Loiola, Erick, additional, Trindade, Pablo, additional, Rangel Vieira, Yasmine, additional, Barbosa-Lima, Giselle, additional, de Castro Faria Neto, Hugo C., additional, Boechat, Nubia, additional, Rehen, Stevens K., additional, Brüning, Karin, additional, Bozza, Fernando A., additional, Bozza, Patrícia T., additional, and Souza, Thiago Moreno L., additional

Published
2019
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13. Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

Author

de Freitas, Caroline S., primary, Higa, Luiza M., additional, Sacramento, Carolina Q., additional, Ferreira, André C., additional, Reis, Patrícia A., additional, Delvecchio, Rodrigo, additional, Monteiro, Fabio L., additional, Barbosa-Lima, Giselle, additional, James Westgarth, Harrison, additional, Vieira, Yasmine Rangel, additional, Mattos, Mayara, additional, Rocha, Natasha, additional, Hoelz, Lucas Villas Bôas, additional, Leme, Rennan Papaleo Paes, additional, Bastos, Mônica M., additional, L. Rodrigues, Gisele Olinto, additional, M. Lopes, Carla Elizabeth, additional, Queiroz-Junior, Celso Martins, additional, Lima, Cristiano X., additional, Costa, Vivian V., additional, Teixeira, Mauro M., additional, Bozza, Fernando A., additional, Bozza, Patrícia T., additional, Boechat, Nubia, additional, Tanuri, Amilcar, additional, and Souza, Thiago Moreno L., additional

Published
2019
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14. Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection

Author

Souza, Thiago Moreno L., primary, Vieira, Yasmine Rangel, additional, Delatorre, Edson, additional, Barbosa-Lima, Giselle, additional, Luiz, Raul Leal Faria, additional, Vizzoni, Alexandre, additional, Jain, Komal, additional, Mesquita, Milene, additional, Bhuva, Nishit, additional, Gogarten, Jan F., additional, Ng, James, additional, Thakkar, Riddhi, additional, Calheiros, Andrea Surrage, additional, Monteiro, Ana Paula Teixeira, additional, Bozza, Patrícia T., additional, Bozza, Fernando A., additional, Tschoeke, Diogo A., additional, Leomil, Luciana, additional, de Mendonça, Marcos Cesar Lima, additional, dos Santos Rodrigues, Cintia Damasceno, additional, Torres, Maria C., additional, de Filippis, Ana Maria Bispo, additional, Nogueira, Rita Maria Ribeiro, additional, Thompson, Fabiano L., additional, Lemos, Cristina, additional, Durovni, Betina, additional, Cerbino-Neto, José, additional, Morel, Carlos M., additional, Lipkin, W. Ian, additional, and Mishra, Nischay, additional

Published
2018
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15. Beyond members of the Flaviviridae family, sofosbuvir also inhibits chikungunya virus replication

Author

Ferreira, André C., primary, Reis, Patrícia A., additional, de Freitas, Caroline S., additional, Sacramento, Carolina Q., additional, Bôas Hoelz, Lucas Villas, additional, Bastos, Mônica M., additional, Mattos, Mayara, additional, Loiola, Erick Correia, additional, Trindade, Pablo, additional, Vieira, Yasmine Rangel, additional, Barbosa-Lima, Giselle, additional, de Castro Faria Neto, Hugo C., additional, Boechat, Nubia, additional, Rehen, Stevens K., additional, Brüning, Karin, additional, Bozza, Fernando A., additional, Bozza, Patrícia T., additional, and Souza, Thiago Moreno L., additional

Published
2018
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16. An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels

Author

Delatorre, Edson, primary, Miranda, Milene, additional, Tschoeke, Diogo A., additional, Carvalho de Sequeira, Patrícia, additional, Alves Sampaio, Simone, additional, Barbosa-Lima, Giselle, additional, Rangel Vieira, Yasmine, additional, Leomil, Luciana, additional, Bozza, Fernando A., additional, Cerbino-Neto, José, additional, Bozza, Patricia T., additional, Ribeiro Nogueira, Rita Maria, additional, Brasil, Patrícia, additional, Thompson, Fabiano L., additional, de Filippis, Ana M. B., additional, and Souza, Thiago Moreno L., additional

Published
2018
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17. Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

Author

Freitas, Caroline S. de, primary, Higa, Luiza M., additional, Sacramento, Carolina, additional, Ferreira, André C., additional, Reis, Patrícia A., additional, Delvecchio, Rodrigo, additional, Monteiro, Fabio Lima, additional, Barbosa-Lima, Giselle, additional, Vieira, Yasmine Rangel, additional, Mattos, Mayara, additional, Hoelz, Lucas Villas Bôas, additional, Leme, Rennan Papaleo Paes, additional, Bastos, Mônica M., additional, Bozza, Fernando A., additional, Bozza, Patrícia T., additional, Boechat, Nubia, additional, Tanuri, Amilcar, additional, and Souza, Thiago Moreno L., additional

Published
2018
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18. Detection of Zika Virus in April 2013 Patient Samples, Rio de Janeiro, Brazil

Author

Passos, Sonia R. Lambert, primary, Borges dos Santos, Maria A., additional, Cerbino-Neto, José, additional, Buonora, Sibelle N., additional, Souza, Thiago M.L., additional, de Oliveira, Raquel V.C., additional, Vizzoni, Alexandre, additional, Barbosa-Lima, Giselle, additional, Vieira, Yasmine R., additional, Silva de Lima, Marcondes, additional, and Hökerberg, Yara H. M., additional

Published
2017
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19. Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae

Author

Ferreira, André C., primary, Zaverucha-do-Valle, Camila, additional, Reis, Patrícia A., additional, Barbosa-Lima, Giselle, additional, Vieira, Yasmine Rangel, additional, Mattos, Mayara, additional, Silva, Priscila de Paiva, additional, Sacramento, Carolina, additional, de Castro Faria Neto, Hugo C., additional, Campanati, Loraine, additional, Tanuri, Amilcar, additional, Brüning, Karin, additional, Bozza, Fernando A., additional, Bozza, Patrícia T., additional, and Souza, Thiago Moreno L., additional

Published
2017
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20. Correction: Corrigendum: The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication

Author

Sacramento, Carolina Q., primary, de Melo, Gabrielle R., additional, de Freitas, Caroline S., additional, Rocha, Natasha, additional, Hoelz, Lucas Villas Bôas, additional, Miranda, Milene, additional, Fintelman-Rodrigues, Natalia, additional, Marttorelli, Andressa, additional, Ferreira, André C., additional, Barbosa-Lima, Giselle, additional, Abrantes, Juliana L., additional, Vieira, Yasmine Rangel, additional, Bastos, Mônica M., additional, Volotão, Eduardo de Mello, additional, Nunes, Estevão Portela, additional, Tschoeke, Diogo A., additional, Leomil, Luciana, additional, Loiola, Erick Correia, additional, Trindade, Pablo, additional, Rehen, Stevens K., additional, Bozza, Fernando A., additional, Bozza, Patrícia T., additional, Boechat, Nubia, additional, Thompson, Fabiano L., additional, de Filippis, Ana M. B., additional, Brüning, Karin, additional, and Souza, Thiago Moreno L., additional

Published
2017
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21. Zika virus evolution and spread in the Americas

Author

Institute for Medical Engineering and Science, Broad Institute of MIT and Harvard, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Metsky, Hayden C., Schaffner, Stephen F, Quigley, James Edwin, Ye, Simon Huang, Park, Daniel, Barnes, Kayla, Gehrke, Lee, Valim, Clarissa, Gnirke, Andreas, Andersen, Kristian, Bosch, Irene, Matranga, Christian B., Wohl, Shirlee, Freije, Catherine A., Winnicki, Sarah M., West, Kendra, Baniecki, Mary Lynn, Gladden-Young, Adrianne, Lin, Aaron E., Tomkins-Tinch, Christopher H., Luo, Cynthia Y., Shah, Rickey R., Chak, Bridget, Barbosa-Lima, Giselle, Delatorre, Edson, Vieira, Yasmine R., Paul, Lauren M., Tan, Amanda L., Barcellona, Carolyn M., Porcelli, Mario C., Vasquez, Chalmers, Cannons, Andrew C., Cone, Marshall R., Hogan, Kelly N., Kopp, Edgar W., Anzinger, Joshua J., Garcia, Kimberly F., Parham, Leda A., Ramírez, Rosa M. Gélvez, Montoya, Maria C. Miranda, Rojas, Diana P., Brown, Catherine M., Hennigan, Scott, Sabina, Brandon, Scotland, Sarah, Gangavarapu, Karthik, Grubaugh, Nathan D., Oliveira, Glenn, Robles-Sikisaka, Refugio, Rambaut, Andrew, Smole, Sandra, Halloran, M. Elizabeth, Villar, Luis, Mattar, Salim, Lorenzana, Ivette, Cerbino-Neto, Jose, Degrave, Wim, Bozza, Patricia T., Isern, Sharon, Michael, Scott F., Bozza, Fernando A., Souza, Thiago M. L., Yozwiak, Nathan L., MacInnis, Bronwyn L., Sabeti, Pardis C., Institute for Medical Engineering and Science, Broad Institute of MIT and Harvard, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Metsky, Hayden C., Schaffner, Stephen F, Quigley, James Edwin, Ye, Simon Huang, Park, Daniel, Barnes, Kayla, Gehrke, Lee, Valim, Clarissa, Gnirke, Andreas, Andersen, Kristian, Bosch, Irene, Matranga, Christian B., Wohl, Shirlee, Freije, Catherine A., Winnicki, Sarah M., West, Kendra, Baniecki, Mary Lynn, Gladden-Young, Adrianne, Lin, Aaron E., Tomkins-Tinch, Christopher H., Luo, Cynthia Y., Shah, Rickey R., Chak, Bridget, Barbosa-Lima, Giselle, Delatorre, Edson, Vieira, Yasmine R., Paul, Lauren M., Tan, Amanda L., Barcellona, Carolyn M., Porcelli, Mario C., Vasquez, Chalmers, Cannons, Andrew C., Cone, Marshall R., Hogan, Kelly N., Kopp, Edgar W., Anzinger, Joshua J., Garcia, Kimberly F., Parham, Leda A., Ramírez, Rosa M. Gélvez, Montoya, Maria C. Miranda, Rojas, Diana P., Brown, Catherine M., Hennigan, Scott, Sabina, Brandon, Scotland, Sarah, Gangavarapu, Karthik, Grubaugh, Nathan D., Oliveira, Glenn, Robles-Sikisaka, Refugio, Rambaut, Andrew, Smole, Sandra, Halloran, M. Elizabeth, Villar, Luis, Mattar, Salim, Lorenzana, Ivette, Cerbino-Neto, Jose, Degrave, Wim, Bozza, Patricia T., Isern, Sharon, Michael, Scott F., Bozza, Fernando A., Souza, Thiago M. L., Yozwiak, Nathan L., MacInnis, Bronwyn L., and Sabeti, Pardis C.

Abstract

Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention1,2, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests., National Institutes of Health (U.S.) (Grant NIAID U19AI110818)

Published
2017

22. The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication

Author

Sacramento, Carolina Q., primary, de Melo, Gabrielle R., additional, de Freitas, Caroline S., additional, Rocha, Natasha, additional, Hoelz, Lucas Villas Bôas, additional, Miranda, Milene, additional, Fintelman-Rodrigues, Natalia, additional, Marttorelli, Andressa, additional, Ferreira, André C., additional, Barbosa-Lima, Giselle, additional, Abrantes, Juliana L., additional, Vieira, Yasmine Rangel, additional, Bastos, Mônica M., additional, de Mello Volotão, Eduardo, additional, Nunes, Estevão Portela, additional, Tschoeke, Diogo A., additional, Leomil, Luciana, additional, Loiola, Erick Correia, additional, Trindade, Pablo, additional, Rehen, Stevens K., additional, Bozza, Fernando A., additional, Bozza, Patrícia T., additional, Boechat, Nubia, additional, Thompson, Fabiano L., additional, de Filippis, Ana M. B., additional, Brüning, Karin, additional, and Souza, Thiago Moreno L., additional

Published
2017
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23. The clinically approved antiviral drug sofosbuvir impairs brazilian zika virus replication

Author

Sacramento, Caroline Q., primary, de Melo, Gabrielle R., additional, Rocha, Natasha, additional, Bôas Hoelz, Lucas Villas, additional, Mesquita, Milene, additional, de Freitas, Caroline S., additional, Fintelman Rodrigues, Natalia, additional, Marttorelli, Andressa, additional, Ferreiral, André C., additional, Barbosa-Lima, Giselle, additional, Bastos, Mônica M., additional, de Mello Volotão, Eduardo, additional, Tschoeke, Diogo A., additional, Leomil, Luciana, additional, Bozza, Fernando A., additional, Bozza, Patrícia T., additional, Boechat, Nubia, additional, Thompson, Fabiano L., additional, de Filippis, Ana M. B., additional, Brüning, Karin, additional, and Souza, Thiago Moreno L., additional

Published
2016
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25. Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection

Author

Assunção-Miranda, Iranaia, primary, Amaral, Flavio A., additional, Bozza, Fernando A., additional, Fagundes, Caio T., additional, Sousa, Lirlandia P., additional, Souza, Danielle G., additional, Pacheco, Patrícia, additional, Barbosa-Lima, Giselle, additional, Gomes, Rachel N., additional, Bozza, Patrícia T., additional, Poian, Andrea T. Da, additional, Teixeira, Mauro M., additional, and Bozza, Marcelo T., additional

Published
2009
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26. Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 Controls Microtubule-Driven Biogenesis and Leukotriene B4-Synthesizing Function of Macrophage Lipid Bodies Elicited by Innate Immune Response

Author

Pacheco, Patricia, primary, Vieira-de-Abreu, Adriana, additional, Gomes, Rachel N., additional, Barbosa-Lima, Giselle, additional, Wermelinger, Leticia B., additional, Maya-Monteiro, Clarissa M., additional, Silva, Adriana R., additional, Bozza, Marcelo T., additional, Castro-Faria-Neto, Hugo C., additional, Bandeira-Melo, Christianne, additional, and Bozza, Patricia T., additional

Published
2007
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27. Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection.

Author

Assunçao-Miranda, Iranaia, Amaral, Flavio A., Bozza, Fernando A., Fagundes, Caio T., Sousa, Lirlandia P., Souza, Danielle G., Pacheco, Patricia, Barbosa-Lima, Giselle, Gomes, Rachel N., Bozza, Patricia T., Da Poian, Andrea T., Teixeira, Mauro M., and Bozza, Marcelo T.

Subjects
MACROPHAGES, DENGUE, HEMORRHAGIC fever, DENGUE viruses, LEUCOCYTES, LIVER cells, PATHOLOGY
Abstract

Dengue fever is an emerging viral disease transmitted by arthropods to humans in tropical countries. Dengue hemorrhagic fever (DHF) is escalating in frequency and mortality rates. Here we studied the involvement of macrophage migration inhibitory factor (MIF) in dengue virus (DENV) infection and its pathogenesis. Patients with DHF had elevated plasma concentrations of MIF. Both leukocytes from these patients and macrophages from healthy donors infected in vitro with DENV showed a substantial amount of MIF within lipid droplets. The secretion of MIF by macrophages and hepatocytes required a productive infection and occurred without an increase in gene transcription or cell death, thus indicating active secretion from preformed stocks. In vivo infection of wild-type and mif-deficient (Mif-/-) mice demonstrated a role of MIF in dengue pathogenesis. Clinical disease was less severe in Mif-/- mice, and they exhibited a significant delay in lethality, lower viremia, and lower viral load in the spleen than wild-type mice. This reduction in all parameters of severity on DENV infection in Mif-/- mice correlated with reduced proinflammatory cytokine concentrations. These results demonstrated the contribution of MIF to the pathogenesis of dengue and pointed to a possible beneficial role of neutralizing MIF as an adjunctive therapeutic approach to treat the severe forms of the disease. [ABSTRACT FROM AUTHOR]

Published
2010
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28. Detection of Zika Virus in April 2013 Patient Samples, Rio de Janeiro, Brazil.

Author

Lambert Passos, Sonia R., Borges dos Santos, Maria A., Cerbino-Neto, José, Buonora, Sibelle N., Souza, Thiago M. L., de Oliveira, Raquel V. C., Vizzoni, Alexandre, Barbosa-Lima, Giselle, Vieira, Yasmine R., des Silva de Lima, Marcon, Hökerberg, Yara H. M., Passos, Sonia R Lambert, and Silva de Lima, Marcondes

Subjects
ZIKA virus, ZIKA virus infections, DENGUE viruses, THERAPEUTICS, VIRAL transmission, PREVENTION
Abstract

We tested 210 dengue virus‒negative samples collected from febrile patients during a dengue virus type 4 outbreak in Rio de Janeiro in April 2013 and found 3 samples positive for Zika virus. Our findings support previously published entomological data suggesting Zika virus was introduced into Brazil during October 2012-May 2013. [ABSTRACT FROM AUTHOR]

Published
2017
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29. Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection

Author

Souza, Thiago Moreno L., Rangel Vieira, Yasmine, Delatorre, Edson, Barbosa-Lima, Giselle, Luiz, Raul Leal Faria, Vizzoni, Alexandre, Jain, Komal, Mesquita Miranda, Milene, Bhuva, Nishit, Gogarten, Jan F., Ng, James, Thakkar, Riddhi, Surrage Calheiros, Andrea, Monteiro, Ana Paula Teixeira, Bozza, Fernando A., Tschoeke, Diogo A., Leomil, Luciana, De Mendonça, Marcos Cesar Lima, Dos Santos Rodrigues, Cintia Damasceno, Torres, Maria C., Bispo De Filippis, Ana Maria, Ribeiro Nogueira, Rita Maria, Thompson, Fabiano L., Lemos, Christina, Durovni, Betina, Cerbino-Neto, José, Morel, Carlos M., Lipkin, W. Ian, and Mishra, Nischay

Subjects
FOS: Computer and information sciences, Viral epidemiology, Bioinformatics, viruses, virus diseases, 610 Medizin und Gesundheit, 3. Good health
Abstract

Brazil, which is hyperendemic for dengue virus (DENV), has had recent Zika (ZIKV) and (CHIKV) Chikungunya virus outbreaks. Since March 2016, CHIKV is the arbovirus infection most frequently diagnosed in Rio de Janeiro. In the analysis of 1835 syndromic patients, screened by real time RT-PCR, 56.4% of the cases were attributed to CHIKV, 29.6% to ZIKV, and 14.1% to DENV-4. Sequence analyses of CHIKV from sixteen samples revealed that the East-Central-South-African (ECSA) genotype of CHIKV has been circulating in Brazil since 2013 [95% bayesian credible interval (BCI): 03/2012-10/2013], almost a year before it was detected by arbovirus surveillance program. Brazilian cases are related to Central African Republic sequences from 1980’s. To the best of our knowledge, given the available sequence published here and elsewhere, the ECSA genotype was likely introduced to Rio de Janeiro early on 2014 (02/2014; BCI: 07/2013-08/2014) through a single event, after primary circulation in the Bahia state at the Northestern Brazil in the previous year. The observation that the ECSA genotype of CHIKV was circulating undetected underscores the need for improvements in molecular methods for viral surveillance.

30. Beyond Members of the FlaviviridaeFamily, Sofosbuvir Also Inhibits Chikungunya Virus Replication

Author

Ferreira, André C., Reis, Patrícia A., de Freitas, Caroline S., Sacramento, Carolina Q., Villas Bôas Hoelz, Lucas, Bastos, Mônica M., Mattos, Mayara, Rocha, Natasha, Gomes de Azevedo Quintanilha, Isaclaudia, da Silva Gouveia Pedrosa, Carolina, Rocha Quintino Souza, Leticia, Correia Loiola, Erick, Trindade, Pablo, Rangel Vieira, Yasmine, Barbosa-Lima, Giselle, de Castro Faria Neto, Hugo C., Boechat, Nubia, Rehen, Stevens K., Brüning, Karin, Bozza, Fernando A., Bozza, Patrícia T., and Souza, Thiago Moreno L.

Abstract

Chikungunya virus (CHIKV) causes a febrile disease associated with chronic arthralgia, which may progress to neurological impairment. Chikungunya fever (CF) is an ongoing public health problem in tropical and subtropical regions of the world, where control of the CHIKV vector, Aedesmosquitos, has failed.

Published
2018
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