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Your search keyword '"Barbuzano, Fernanda Gonçalves"' showing total 3 results
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3 results on '"Barbuzano, Fernanda Gonçalves"'

2. miR-15a and 16-1 Are Downregulated in CD4+ T Cells of Multiple Sclerosis Relapsing Patients.

Author

Lorenzi, Julio Cesar Cetrulo, Brum, Doralina G., Zanette, Dalila L., de Paula Alves Souza, Alessandra, Barbuzano, Fernanda Gonçalves, dos Santos, Antonio Carlos, Barreira, Amilton Antunes, and da Silva, Wilson Araujo

Subjects
CD4 antigen, T cells, MULTIPLE sclerosis, IMMUNE response, APOPTOSIS, GENE expression, MICRORNA, PATHOLOGY, BCL-2 genes, PATIENTS
Abstract

The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. The influence of microRNAs on the immune response has been shown to occur in different pathways of lymphocyte differentiation and function. Here, the expression of the miRNAs miR-15a/16-1 in PBMC, CD4+, and CD8+ from RR-MS patients has been investigated. BCL2, a known miR-15a/16-1 target, has also been analyzed. The results have shown that miR-15a/16-1 is downregulated in CD4+ T cells, whereas BCL2 is highly expressed in RR-MS patients only. Our data suggest that miR-15a/16-1 can also modulate the BCL2 gene expression in CD4+ T cells from RR-MS patients, thereby affecting apoptosis processes. [ABSTRACT FROM AUTHOR]

Published
2012
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3. miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients.

Author

Lorenzi JC, Brum DG, Zanette DL, de Paula Alves Souza A, Barbuzano FG, Dos Santos AC, Barreira AA, and da Silva WA

Subjects
Adult, CD8-Positive T-Lymphocytes metabolism, Case-Control Studies, Cell Proliferation, Disability Evaluation, Female, Humans, Lymphocyte Activation immunology, Male, MicroRNAs genetics, Proto-Oncogene Proteins c-bcl-2 metabolism, RNA, Messenger metabolism, Young Adult, CD4-Positive T-Lymphocytes metabolism, Down-Regulation immunology, MicroRNAs metabolism, Multiple Sclerosis, Relapsing-Remitting genetics, Multiple Sclerosis, Relapsing-Remitting immunology, Multiple Sclerosis, Relapsing-Remitting metabolism
Abstract

The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. The influence of microRNAs on the immune response has been shown to occur in different pathways of lymphocyte differentiation and function. Here, the expression of the miRNAs miR-15a/16-1 in PBMC, CD4(+), and CD8(+) from RR-MS patients has been investigated. BCL2, a known miR-15a/16-1 target, has also been analyzed. The results have shown that miR-15a/16-1 is downregulated in CD4(+) T cells, whereas BCL2 is highly expressed in RR-MS patients only. Our data suggest that miR-15a/16-1 can also modulate the BCL2 gene expression in CD4(+) T cells from RR-MS patients, thereby affecting apoptosis processes.

Published
2012
Full Text
View/download PDF

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