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9 results on '"Barez, Pierre-Yves"'

2. WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?

Author

Gillet Nicolas, Carpentier Alexandre, Barez Pierre-Yves, and Willems Luc

Subjects
HTLV-1, Tax, HBZ, p53, Wip1, PPM1D, MDM2, DNA damage response, Genomic stress, ATM, Chk2, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-induced phosphatase 1 (Wip1), contributes to Tax-induced oncogenesis in a mouse model. Wip1 may therefore be a novel target for therapeutic approaches.

Published
2012
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3. Quantification of cell turnover in the bovine Leukemia virus model

Author

de Brogniez, Alix, Barez, Pierre-Yves, Carpentier, Alexandre, Gutiérrez, Gerónimo, Reichert, Michal, Trono, Karina Gabriela, and Willems, Luc

Subjects
Ciencias Biológicas, HTLV-1, CFDA-SE, Otras Ciencias Biológicas, DELTARETROVIRUS, PROLIFERATION, BOVINE LEUKEMIA VIRUS, CIENCIAS NATURALES Y EXACTAS, APOPTOSIS
Abstract

In a perspective of a comparative virology approach, characterization of the bovine leukemia virus (BLV) model may be helpful to better understand infection by the related human T-lymphotropic virus type 1 (HTLV-1). In this paper, we first provide detailed protocols to inoculate cloned BLV proviruses into sheep or cattle. We also describe methods to quantify apoptosis ex vivo and cell turnover in vivo. Fil: de Brogniez, Alix. Université de Liège; Bélgica Fil: Barez, Pierre-Yves. Université de Liège; Bélgica Fil: Carpentier, Alexandre. Université de Liège; Bélgica Fil: Gutiérrez, Gerónimo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires; Argentina Fil: Reichert, Michal. National Veterinary Research Institute; Polonia Fil: Trono, Karina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires; Argentina Fil: Willems, Luc. Université de Liège; Bélgica

Published
2017
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4. From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound

Author

Hamaidia, Malik, primary, Barez, Pierre-Yves, primary, Carpentier, Alexandre, primary, Lebecque, Simon, primary, Miazek, Krystian, primary, Paul, Aman, primary, Sriramareddy, Sathya Neelature, primary, Staumont, Bernard, primary, Danthine, Sabine, primary, Deleu, Magali, primary, Frédérich, Michel, primary, Pauw, Edwin De, primary, Delaplace, Pierre, primary, Delvigne, Frank, primary, Goffin, Dorothée, primary, Ongena, Marc, primary, Duysinx, Bernard, primary, Louis, Renaud, primary, Cosse, Jean-Philippe, primary, and Willems, Luc, primary

Published
2016
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5. Recent Advances in BLV Research

Author

Barez, Pierre-Yves, primary, de Brogniez, Alix, additional, Carpentier, Alexandre, additional, Gazon, Hélène, additional, Gillet, Nicolas, additional, Gutiérrez, Gerónimo, additional, Hamaidia, Malik, additional, Jacques, Jean-Rock, additional, Perike, Srikanth, additional, Neelature Sriramareddy, Sathya, additional, Renotte, Nathalie, additional, Staumont, Bernard, additional, Reichert, Michal, additional, Trono, Karina, additional, and Willems, Luc, additional

Published
2015
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9. Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence.

Author

Gazon, Hélène, de Brogniez, Alix, Willems, Luc, Carpentier, Alexandre, Barez, Pierre-Yves, Hamaidia, Malik, Perike, Srikanth, and Gillet, Nicolas

Subjects
HTLV-I, VIRAL replication, RETROVIRUS diseases, VIRION, DNA replication, RNA modification & restriction, GENETICS
Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy--tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans. [ABSTRACT FROM AUTHOR]

Published
2015
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