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Your search keyword '"Barhate, Chandan L."' showing total 17 results
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17 results on '"Barhate, Chandan L."'

7. Microscale purification in support of high-throughput medicinal chemistry

Author

Barhate, Chandan L., primary, Donnell, Andrew F., additional, Davies, Merrill, additional, Li, Ling, additional, Zhang, Yong, additional, Yang, Fukang, additional, Black, Regina, additional, Zipp, Greg, additional, Zhang, Yingru, additional, Cavallaro, Cullen L., additional, Priestley, E. Scott, additional, and Weller, Harold N., additional

Published
2021
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13. Salient Sub-Second Separations

Author

Wahab, M. Farooq, primary, Wimalasinghe, Rasangi M., additional, Wang, Yadi, additional, Barhate, Chandan L., additional, Patel, Darshan C., additional, and Armstrong, Daniel W., additional

Published
2016
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16. Ultrafast chiral separations for high throughput enantiopurity analysis.

Author

Joyce, Leo A., Makarov, Alexey A., Zawatzky, Kerstin, Bernardoni, Frank, Schafer, Wes A., Welch, Christopher J., Regalado, Erik L., Barhate, Chandan L., and Armstrong, Daniel W.

Subjects
SEPARATION of enantiomers, LIQUID chromatography, SUPERCRITICAL fluid chromatography
Abstract

Recent developments in fast chromatographic enantioseparations now make high throughput analysis of enantiopurity on the order of a few seconds achievable. Nevertheless, routine chromatographic determinations of enantiopurity to support stereochemical investigations in pharmaceutical research and development, synthetic chemistry and bioanalysis are still typically performed on the 5–20 min timescale, with many practitioners believing that sub-minute enantioseparations are not representative of the molecules encountered in day to day research. In this study we develop ultrafast chromatographic enantioseparations for a variety of pharmaceutically-related drugs and intermediates, showing that sub-minute resolutions are now possible in the vast majority of cases by both supercritical fluid chromatography (SFC) and reversed phase liquid chromatography (RP-LC). Examples are provided illustrating how such methods can be routinely developed and used for ultrafast high throughput analysis to support enantioselective synthesis investigations. [ABSTRACT FROM AUTHOR]

Published
2017
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17. Ni/Photoredox-Catalyzed C(sp 2 )-C(sp 3 ) Cross-Coupling of Alkyl Pinacolboronates and (Hetero)Aryl Bromides.

Author

Cauley AN, Ramirez A, Barhate CL, Donnell AF, Khandelwal P, Sezen-Edmonds M, Sherwood TC, Sloane JL, Cavallaro CL, and Simmons EM

Subjects
Catalysis, Esters, Nickel, Bromides, Quinolines
Abstract

Utilizing quinoline as a mild, catalytic additive, broadly applicable conditions for the Ni/photoredox-catalyzed C(sp 2 )-C(sp 3 ) cross-coupling of (hetero)aryl bromides and alkyl pinacolboronate esters were developed, which can be applied to both batch and flow reactions. In addition to primary benzylic nucleophiles, both stabilized and nonstabilized secondary alkyl boronic esters are effective coupling partners. Density functional theory calculations suggest that alkyl radical generation occurs from an alkyl-B(pin)-quinoline complex, which may proceed via an energy transfer process.

Published
2022
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