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4. Comparison of in vitro fosfomycin susceptibility testing methods with agar dilution for carbapenem resistant Klebsiella pneumoniaeand Escherichiacoli

Author

Pereira, Joanna Valanie, Bari, Anurag Kumar, Kokare, Rashmi, and Poojary, Aruna

Abstract

The emergence of Extensively drug resistant (XDR) pathogens like Carbapenem Resistant Klebsiella pneumoniae(CR Kpn) and Carbapenem Resistant Escherichia coli(CR Eco) has limited therapeutic options for treating them. Fosfomycin a broad-spectrum antibiotic, has emerged as a potential treatment option in combination with other agents. It is therefore important that accurate drug susceptibility testing (DST) results of fosfomycin should be available to all clinical microbiology laboratories. Agar dilution which is the recommended method for fosfomycin DST is not convenient to adopt in a routine set-up. This study aimed to determine the susceptibility pattern of CR Kpn and CR Eco to fosfomycin and to evaluate the discrepancies of the available manual MIC based alternative methods.

Published
2023
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5. Circulation of Third-Generation Cephalosporin Resistant Salmonella Typhi in Mumbai, India

Author

Argimón, Silvia, primary, Nagaraj, Geetha, additional, Shamanna, Varun, additional, Sravani, Dharmavaram, additional, Vasanth, Ashwini Kodlipet, additional, Prasanna, Akshatha, additional, Poojary, Aruna, additional, Bari, Anurag Kumar, additional, Underwood, Anthony, additional, Kekre, Mihir, additional, Baker, Stephen, additional, Aanensen, David M, additional, and Lingegowda, Ravikumar Kadahalli, additional

Published
2021
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6. Circulation of Third-Generation Cephalosporin Resistant Salmonella Typhi in Mumbai, India.

Author

Argimón, Silvia, Nagaraj, Geetha, Shamanna, Varun, Sravani, Dharmavaram, Vasanth, Ashwini Kodlipet, Prasanna, Akshatha, Poojary, Aruna, Bari, Anurag Kumar, Underwood, Anthony, Kekre, Mihir, Baker, Stephen, Aanensen, David M, and Lingegowda, Ravikumar Kadahalli

Subjects
GENETIC mutation, FLUOROQUINOLONES, TYPHOID fever, THIRD generation cephalosporins, SALMONELLA, BETA lactamases, DRUG resistance in microorganisms, MICROBIAL sensitivity tests
Abstract

We report the persistent circulation of third-generation cephalosporin resistant Salmonella Typhi in Mumbai, linked to the acquisition and maintenance of a previously characterized IncX3 plasmid carrying the ESBL gene bla SHV-12 and the fluoroquinolone resistance gene qnrB7 in the genetic context of a triple mutant also associated with fluoroquinolone resistance. [ABSTRACT FROM AUTHOR]

Published
2022
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