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1. Juvenile Uveitis

Author

Eidherr, Markus, Jarz-Lackner, Hildrun, Bolz, Matthias, Barisani-Asenbauer, Talin, and Strauß, Rupert W.

Published
2024
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2. The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 2—global current practice patterns for the management of Cytomegalovirus anterior uveitis

Author

Thng, Zheng Xian, Putera, Ikhwanuliman, Testi, Ilaria, Chan, Kevin, Westcott, Mark, Chee, Soon-Phaik, Dick, Andrew D., Kempen, John H., Bodaghi, Bahram, Thorne, Jennifer E., Barisani-Asenbauer, Talin, de Smet, Marc D., Smith, Justine R., McCluskey, Peter, La Distia Nora, Rina, Jabs, Douglas A., de Boer, Joke H., Sen, H. Nida, Goldstein, Debra A., Khairallah, Moncef, Davis, Janet L., Rosenbaum, James T., Jones, Nicholas P., Nguyen, Quan Dong, Pavesio, Carlos, Agrawal, Rupesh, and Gupta, Vishali

Published
2024
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3. The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 1—global current practice patterns for the management of Herpes Simplex Virus and Varicella Zoster Virus anterior uveitis

Author

Thng, Zheng Xian, Putera, Ikhwanuliman, Testi, Ilaria, Chan, Kevin, Westcott, Mark, Chee, Soon-Phaik, Dick, Andrew D., Kempen, John H., Bodaghi, Bahram, Thorne, Jennifer E., Barisani-Asenbauer, Talin, de Smet, Marc D., Smith, Justine R., McCluskey, Peter, La Distia Nora, Rina, Jabs, Douglas A., de Boer, Joke H., Sen, H. Nida, Goldstein, Debra A., Khairallah, Moncef, Davis, Janet L., Rosenbaum, James T., Jones, Nicholas P., Nguyen, Quan Dong, Pavesio, Carlos, Agrawal, Rupesh, and Gupta, Vishali

Published
2024
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8. Immunoglobulins

Author

Barisani-Asenbauer, Talin, Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor

Published
2016
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13. A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis - A phase I clinical trial

Author

Thurau, Stephan, Deuter, Christoph ME, Heiligenhaus, Arnd, Pleyer, Uwe, Van Calster, Joachim, Barisani-Asenbauer, Talin, Obermayr, Franz, Sperl, Stefan, Seda-Zehetner, Romana, and Wildner, Gerhild

Subjects
Science & Technology, experimental autoimmune uveitis, macular edema, visual acuity, AUTOIMMUNE, DE-NOVO, General Medicine, STANDARDIZATION, LYMPHOCYTES, clinical phase 1 trial, INTERMEDIATE, Medicine, General & Internal, INFLAMMATION, POSTERIOR, General & Internal Medicine, B-CELLS, TERIFLUNOMIDE, uveitis, MAST-CELLS, rat, humans, Life Sciences & Biomedicine, intravitreal therapy
Abstract

Uveitis is a T cell-mediated, intraocular inflammatory disease and one of the main causes of blindness in industrialized countries. There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-infectious uveitis. A new small molecule inhibitor of dihydroorotate dehydrogenase (DHODH), an enzyme pivotal forde novosynthesis of pyrimidines, has a high potency for suppressing T and B cells and has already proven highly effective for treating uveitis in experimental rat models. Systemic and intraocular application of KIO-100 (PP-001) (previously called PP-001, now KIO-100) could efficiently suppress rat uveitis in a preventive as well as therapeutic mode. Here we describe the outcome of the first clinical phase 1 trial comparing three different doses of a single intraocular injection of KIO-100 (PP-001) in patients with non-infectious posterior segment uveitis. No toxic side effects on intraocular tissues or other adverse events were observed, while intraocular inflammation decreased, and visual acuity significantly improved. Macular edema, a sight-threatening complication in uveitis, showed regression 2 weeks after intraocular KIO-100 (PP-001) injection in some patients, indicating that this novel small molecule has a high potential as a new intraocular therapy for uveitis.Clinical trial registration[https://www.clinicaltrials.gov/ct2/show/NCT03634475], identifier [NCT03634475].

Published
2022

17. The standardisation of uveitis nomenclature (SUN) project.

Author

Jabs, Douglas A., McCluskey, Peter, Palestine, Alan G., Thorne, Jennifer E., The Standardization of Uveitis Nomenclature Working Group, Accorinti, Massimo, Acharya, Nisha, Amer, Radgonde, Atmaca, Leyla S., Bar, Asaf, Barisani‐Asenbauer, Talin, Becker, Matthias D., Bélair, Marie‐Lyne, Belfort, Rubens, Bhatt, Nirali P., Biswas, Jyotirmay, Blodi, Barbara, Bodaghi, Bahram, Brézin, Antoine P., and Butler, Nicholas J.

Subjects
UVEITIS, EYE inflammation, MACHINE learning, TRANSLATIONAL research, IRIDOCYCLITIS
Abstract

The uveitides are a collection of over 30 diseases characterised by intraocular inflammation. Previous work demonstrated that the agreement among uveitis experts on diagnosis was modest at best with some pairs of experts having chance alone agreement on selected diseases. The Standardisation of Uveitis Nomenclature (SUN) is a17‐year collaboration among experts in uveitis, ocular image grading, informatics, and machine learning to improve clinical and translational uveitis research. The SUN "Developing Classification Criteria for the Uveitides" project used a rigorous, multi‐phase approach to develop classification criteria for 25 of the most common uveitic diseases. The project's phases were: (1) informatics; (2) case collection; (3) case selection; (4) machine learning; and (5) consensus review and publication. The results were classification criteria with a high degree of accuracy (93.3%–99.3% depending on anatomic class of the uveitis), the goal of which is to form the basis for future uveitis research. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Characteristics of Chlamydia suis Ocular Infection in Pigs

Author

Unterweger, Christine, primary, Inic-Kanada, Aleksandra, additional, Setudeh, Sara, additional, Knecht, Christian, additional, Duerlinger, Sophie, additional, Stas, Melissa, additional, Vanrompay, Daisy, additional, Kiekens, Celien, additional, Steinparzer, Romana, additional, Gerner, Wilhelm, additional, Ladinig, Andrea, additional, and Barisani-Asenbauer, Talin, additional

Published
2021
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21. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis

Author

Agrawal, Rupesh, Testi, Ilaria, Bodaghi, Baharam, Barisani-Asenbauer, Talin, McCluskey, Peter, Agarwal, Aniruddha, Kempen, John H, Gupta, Amod, Smith, Justine R, de Smet, Marc D, Yuen, Yew Sen, Mahajan, Sarakshi, Kon, Onn Min, Nguyen, Quan Dong, Pavesio, Carlos, and Gupta, Vishali

Subjects
education, 610 Medicine & health
Abstract

TOPIC The Collaborative Ocular Tuberculosis Study (COTS), supported by the International Ocular Inflammation Society, International Uveitis Study Group, and Foster Ocular Immunological Society, set up an international, expert-led consensus project to develop evidence- and experience-based guidelines for the management of tubercular uveitis (TBU). CLINICAL RELEVANCE The absence of international agreement on the use of antitubercular therapy (ATT) in patients with TBU contributes to a significant heterogeneity in the approach to the management of this condition. METHODS Consensus statements for the initiation of ATT in TBU were generated using a 2-step modified Delphi technique. In Delphi step 1, a smart web-based survey based on background evidence from published literature was prepared to collect the opinion of 81 international experts on the use of ATT in different clinical scenarios. The survey included 324 questions related to tubercular anterior uveitis (TAU), tubercular intermediate uveitis (TIU), tubercular panuveitis (TPU), and tubercular retinal vasculitis (TRV) administered by the experts, after which the COTS group met in November 2019 for a systematic and critical discussion of the statements in accordance with the second round of the modified Delphi process. RESULTS Forty-four consensus statements on the initiation of ATT in TAU, TIU, TPU, and TRV were obtained, based on ocular phenotypes suggestive of TBU and corroborative evidence of tuberculosis, provided by several combinations of immunologic and radiologic test results. Experts agreed on initiating ATT in recurrent TAU, TIU, TPU, and active TRV depending on the TB endemicity. In the presence of positive results for any 1 of the immunologic tests along with radiologic features suggestive of past evidence of tuberculosis infection. In patients with a first episode of TAU, consensus to initiate ATT was reached only if both immunologic and radiologic test results were positive. DISCUSSION The COTS consensus guidelines were generated based on the evidence from published literature, specialists' opinions, and logic construction to address the initiation of ATT in TBU. The guidelines also should inform public policy by adding specific types of TBU to the list of conditions that should be treated as tuberculosis.

Published
2021
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23. The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 1—global current practice patterns for the management of Herpes Simplex Virus and Varicella Zoster Virus anterior uveitis

Author

Thng, Zheng Xian, Putera, Ikhwanuliman, Testi, Ilaria, Chan, Kevin, Westcott, Mark, Chee, Soon-Phaik, Dick, Andrew D., Kempen, John H., Bodaghi, Bahram, Thorne, Jennifer E., Barisani-Asenbauer, Talin, de Smet, Marc D., Smith, Justine R., McCluskey, Peter, La Distia Nora, Rina, Jabs, Douglas A., de Boer, Joke H., Sen, H. Nida, Goldstein, Debra A., Khairallah, Moncef, Davis, Janet L., Rosenbaum, James T., Jones, Nicholas P., Nguyen, Quan Dong, Pavesio, Carlos, Agrawal, Rupesh, and Gupta, Vishali

Abstract

Aims: To present current expert practice patterns and to formulate a consensus for the management of HSV and VZV AU by uveitis specialists worldwide. Methods: A two-round online modified Delphi survey with masking of the study team was conducted. Responses were collected from 76 international uveitis experts from 21 countries. Current practices in the diagnosis and treatment of HSV and VZV AU were identified. A working group (The Infectious Uveitis Treatment Algorithm Network [TITAN]) developed data into consensus guidelines. Consensus is defined as a particular response towards a specific question meeting ≥75% of agreement or IQR ≤ 1 when a Likert scale is used. Results: Unilaterality, increased intraocular pressure (IOP), decreased corneal sensation and diffuse or sectoral iris atrophy are quite specific for HSV or VZV AU from consensus opinion. Sectoral iris atrophy is characteristic of HSV AU. Treatment initiation is highly variable, but most experts preferred valacyclovir owing to simpler dosing. Topical corticosteroids and beta-blockers should be used if necessary. Resolution of inflammation and normalisation of IOP are clinical endpoints. Conclusions: Consensus was reached on several aspects of diagnosis, choice of initial treatment, and treatment endpoints for HSV and VZV AU. Treatment duration and management of recurrences varied between experts.

Published
2023
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24. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis—Report 1

Author

Agrawal, Rupesh, primary, Testi, Ilaria, additional, Mahajan, Sarakshi, additional, Yuen, Yew Sen, additional, Agarwal, Aniruddha, additional, Kon, Onn Min, additional, Barisani-Asenbauer, Talin, additional, Kempen, John H., additional, Gupta, Amod, additional, Jabs, Douglas A., additional, Smith, Justine R., additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, Gupta, Vishali, additional, Agarwal, Mamta, additional, Agarwal, Manisha, additional, Aggarwal, Ashutosh, additional, Aggarwal, Kanika, additional, Agrawal, Mukesh, additional, Al-Dhibi, Hassan, additional, Androudi, Sofia, additional, Asyari, Fatma, additional, Balasundaram, Manohar Babu, additional, Murthy, Kalpana Babu, additional, Baglivo, Edoardo, additional, Banker, Alay, additional, Bansal, Reema, additional, Basu, Soumyava, additional, Behera, Digamber, additional, Biswas, Jyotirmay, additional, Bodaghi, Bahram, additional, Carreño, Ester, additional, Caspers, Laure, additional, Chee, Soon Phaik, additional, Chhabra, Romi, additional, Cimino, Luca, additional, Concha del Rio, Luz Elena, additional, Cunningham, Emmett T., additional, Land Curi, Andrè Luiz, additional, Das, Dipankar, additional, Davis, Janet, additional, DeSmet, Marc, additional, Denisova, Ekaterina, additional, Denniston, Alastair K., additional, Errera, Marie-Hélène, additional, Fonollosa, Alejandro, additional, George, Amala, additional, Goldstein, Debra A., additional, Crosier, Yan Guex, additional, Gunasekeran, Dinesh Visva, additional, Gurbaxani, Avinash, additional, Invernizzi, Alessandro, additional, Isa, Hazlita M., additional, Islam, Shah Md., additional, Jones, Nicholas, additional, Katoch, Deeksha, additional, Khairallah, Moncef, additional, Khosla, Amit, additional, Kramer, Michal, additional, Kumar, Amitabh, additional, Kumar, Atul, additional, La Distia Nora, Rina, additional, Lee, Richard, additional, Lowder, Careen, additional, Luthra, Saurabh, additional, Mahendradas, Padmamalini, additional, Makhoul, Dorine, additional, Mazumdar, Shahana, additional, McCluskey, Peter, additional, Mehta, Salil, additional, Miserocchi, Elisabetta, additional, Mochizuki, Manabu, additional, Mohamed, Oli S., additional, Muccioli, Cristina, additional, Munk, Marion R., additional, Murthy, Somasheila, additional, Narain, Shishir, additional, Nascimento, Heloisa, additional, Neri, Piergiorgio, additional, Nguyen, Myhanh, additional, Okada, Annabelle A., additional, Ozdal, Pinar, additional, Palestine, Alan, additional, Pichi, Francesco, additional, Raje, Dhananjay, additional, Rathinam, S.R., additional, Rousselot, Andres, additional, Schlaen, Ariel, additional, Sehgal, Shobha, additional, Sen, H. Nida, additional, Sharma, Aman, additional, Sharma, Kusum, additional, Shoughy, Samir S., additional, Singh, Nirbhai, additional, Singh, Ramandeep, additional, Soheilian, Masoud, additional, Sridharan, Sudharshan, additional, Thorne, Jennifer E., additional, Tappeiner, Christoph, additional, Teoh, Stephen, additional, Tognon, Maria Sofia, additional, Tugal-Tutkun, Ilknur, additional, Tyagi, Mudit, additional, Uy, Harvey, additional, Vasconcelos Santos, Daniel Vitor, additional, Valentincic, Natasa Vidovic, additional, Westcott, Mark, additional, Yanai, Ryoji, additional, Alvarez, Bety Yanez, additional, Zahedur, Rahman, additional, and Zierhut, Manfred, additional

Published
2021
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25. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis—Report 2

Author

Agrawal, Rupesh, primary, Testi, Ilaria, additional, Bodaghi, Baharam, additional, Barisani-Asenbauer, Talin, additional, McCluskey, Peter, additional, Agarwal, Aniruddha, additional, Kempen, John H., additional, Gupta, Amod, additional, Smith, Justine R., additional, de Smet, Marc D., additional, Yuen, Yew Sen, additional, Mahajan, Sarakshi, additional, Kon, Onn Min, additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, Gupta, Vishali, additional, Agrawal, Rupesh, additional, Agarwal, Mamta, additional, Agarwal, Manisha, additional, Aggarwal, Ashutosh, additional, Aggarwal, Kanika, additional, Agrawal, Mukesh, additional, Al-Dhibi, Hassan, additional, Androudi, Sofia, additional, Asyari, Fatma, additional, Balasundaram, Manohar Babu, additional, Murthy, Kalpana Babu, additional, Baglivo, Edoardo, additional, Banker, Alay, additional, Bansal, Reema, additional, Basu, Soumyava, additional, Behera, Digamber, additional, Biswas, Jyotirmay, additional, Carreño, Ester, additional, Caspers, Laure, additional, Chee, Soon Phaik, additional, Chhabra, Romi, additional, Cimino, Luca, additional, Concha del Rio, Luz Elena, additional, Cunningham, Emmett T., additional, Land Curi, Andrè Luiz, additional, Das, Dipankar, additional, Davis, Janet, additional, DeSmet, Marc, additional, Denisova, Ekaterina, additional, Denniston, Alastair K., additional, Errera, Marie-Hélène, additional, Fonollosa, Alejandro, additional, George, Amala, additional, Goldstein, Debra A., additional, Crosier, Yan Guex, additional, Gunasekeran, Dinesh Visva, additional, Gurbaxani, Avinash, additional, Invernizzi, Alessandro, additional, Isa, Hazlita M., additional, Islam, Shah M.d., additional, Jones, Nicholas, additional, Katoch, Deeksha, additional, Khairallah, Moncef, additional, Khosla, Amit, additional, Kramer, Michal, additional, Kumar, Amitabh, additional, Kumar, Atul, additional, La Distia Nora, Rina, additional, Lee, Richard, additional, Lowder, Careen, additional, Luthra, Saurabh, additional, Mahendradas, Padmamalini, additional, Makhoul, Dorine, additional, Mazumdar, Shahana, additional, Mehta, Salil, additional, Miserocchi, Elisabetta, additional, Mochizuki, Manabu, additional, Mohamed, Oli S., additional, Muccioli, Cristina, additional, Munk, Marion R., additional, Murthy, Somasheila, additional, Narain, Shishir, additional, Nascimento, Heloisa, additional, Neri, Piergiorgio, additional, Nguyen, Myhanh, additional, Okada, Annabelle A., additional, Ozdal, Pinar, additional, Palestine, Alan, additional, Pichi, Francesco, additional, Raje, Dhananjay, additional, Rathinam, S.R., additional, Rousselot, Andres, additional, Schlaen, Ariel, additional, Sehgal, Shobha, additional, Nida Sen, H., additional, Sharma, Aman, additional, Sharma, Kusum, additional, Shoughy, Samir S., additional, Singh, Nirbhai, additional, Singh, Ramandeep, additional, Soheilian, Masoud, additional, Sridharan, Sudharshan, additional, Thorne, Jennifer E., additional, Tappeiner, Christoph, additional, Teoh, Stephen, additional, Tognon, Maria Sofia, additional, Tugal-Tutkun, Ilknur, additional, Tyagi, Mudit, additional, Uy, Harvey, additional, Vasconcelos Santos, Daniel Vitor, additional, Valentincic, Natasa Vidovic, additional, Westcott, Mark, additional, Yanai, Ryoji, additional, Alvarez, Bety Yanez, additional, Zahedur, Rahman, additional, Zierhut, Manfred, additional, and Xian, Zheng, additional

Published
2021
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26. Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia

Author

Stojanović, Marijana, Lukić, Ivana, Marinković, Emilija, Kovačević, Ana, Miljković, Radmila, Tobias, Joshua, Schabussova, Irma, Zlatović, Mario, Barisani-Asenbauer, Talin, Wiedermann, Ursula, Inic-Kanada, Aleksandra, Stojanović, Marijana, Lukić, Ivana, Marinković, Emilija, Kovačević, Ana, Miljković, Radmila, Tobias, Joshua, Schabussova, Irma, Zlatović, Mario, Barisani-Asenbauer, Talin, Wiedermann, Ursula, and Inic-Kanada, Aleksandra

Abstract

Vaccines can have heterologous effects on the immune system, i.e., effects other than triggering an immune response against the disease targeted by the vaccine. We investigated whether monoclonal antibodies (mAbs) specific for tetanus could cross-react with Chlamydia and confer heterologous protection against chlamydial infection. The capability of two tetanus-specific mAbs, namely mAb26 and mAb51, to prevent chlamydial infection has been assessed: (i) in vitro, by performing a neutralization assay using human conjunctival epithelial (HCjE) cells infected with Chlamydia trachomatis serovar B, and (ii) in vivo, by using a guinea pig model of Chlamydiacaviae-induced inclusion conjunctivitis. The mAb26 has been superior in comparison with mAb51 in the prevention of chlamydial infection in HCjE cells. The mAb26 has conferred ≈40% inhibition of the infection, compared to less than 5% inhibition in the presence of the mAb51. In vivo, mAb26 significantly diminished ocular pathology intensity in guinea pigs infected with C. caviae compared to either the mAb51-treated or sham-treated guinea pigs. Our data provide insights that tetanus immunization generates antibodies which induce heterologous chlamydial immunity and promote protection beyond the intended target pathogen.

Published
2020

27. DNA methylation of miR-200 clusters promotes epithelial to mesenchymal transition in human conjunctival epithelial cells.

Author

Rajić, Jovana, Dinić, Svetlana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Tolić, Anja, Đorđević, Marija, Đorđević, Miloš, Poznanović, Goran, Mihailović, Mirjana, Inic-Kanada, Aleksandra, Barisani-Asenbauer, Talin, Grdović, Nevena, Vidaković, Melita, Rajić, Jovana, Dinić, Svetlana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Tolić, Anja, Đorđević, Marija, Đorđević, Miloš, Poznanović, Goran, Mihailović, Mirjana, Inic-Kanada, Aleksandra, Barisani-Asenbauer, Talin, Grdović, Nevena, and Vidaković, Melita

Abstract

Epithelial to mesenchymal transition (EMT) contributes to fibrosis associated pathologies including scarring of different ocular tissues. Recently targeting EMT is seen as an appropriate therapeutic approach for different fibrosis related eye diseases such as macular degeneration or glaucoma surgery related fibrosis. Nevertheless, for ocular surface diseases, target genes specific for particular cell type or condition are still undefined. This study aimed to expose the complex regulatory mechanisms that trigger EMT in human conjunctival epithelial (HCjE) cells. EMT was induced by prolonged treatment with two TGF-β isoforms, TGF-β1 and TGF-β2, and their combination. TGF-β1 showed the strongest potential for initiating EMT in HCjE cells, reflected on morphological changes, cell migration and the levels of mRNA expression of different epithelial (CDH1, OCLN, DSP) and mesenchymal (CDH2, FN1, VIM, SNAI1, ZEB2, TWIST1) marker genes. Co-treatment with the DNA demethylating agent 5-Azacytidine (5-AzaC) was capable of stopping the transition of HCjE cells towards a mesenchymal phenotype, based on morphological features, reduced cell mobility and mRNA and protein expression levels of epithelial and mesenchymal marker genes. An EMT qRT-PCR-based array revealed that EMT induced considerable alterations in gene expression, with downregulation of the majority of epithelial marker genes and upregulation of genes specific for the mesenchymal state. The major effect of 5-AzaC treatment was observed as a suppression of mesenchymal marker genes, suggesting the involvement of upstream negative regulator(s) whose promoter demethylation and subsequent expression will in turn promote EMT switch off. The expression level of miRNAs potentially important for EMT induction was determined using qRT-PCR-based array which pointed at members of miR-200 family as main regulators of EMT process in HCjE cells. 5-AzaC treatment induced increased expression of miR-200a, -200b, -200c and miR-141 toward

Published
2020

28. Supplementary information for the article: Stojanović, M.; Lukić, I.; Marinković, E.; Kovačević, A.; Miljković, R.; Tobias, J.; Schabussova, I.; Zlatović, M.; Barisani-Asenbauer, T.; Wiedermann, U.; Inić-Kanada, A. Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia. Vaccines 2020, 8 (4), 719. https://doi.org/10.3390/vaccines8040719.

Author

Stojanović, Marijana, Lukić, Ivana, Marinković, Emilija, Kovačević, Ana, Miljković, Radmila, Tobias, Joshua, Schabussova, Irma, Zlatović, Mario, Barisani-Asenbauer, Talin, Wiedermann, Ursula, Inić-Kanada, Aleksandra, Stojanović, Marijana, Lukić, Ivana, Marinković, Emilija, Kovačević, Ana, Miljković, Radmila, Tobias, Joshua, Schabussova, Irma, Zlatović, Mario, Barisani-Asenbauer, Talin, Wiedermann, Ursula, and Inić-Kanada, Aleksandra

Abstract

Table S1: Characteristics of selected anti-tetanus mAbs [35,36].

Published
2020

29. Cross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydia

Author

Stojanović, Marijana M., Lukić, Ivana, Marinković, Emilija, Kovačević, Ana, Miljković, Radmila, Tobias, Joshua, Schabussova, Irma, Zlatović, Mario, Barisani-Asenbauer, Talin, Wiedermann, Ursula, Inic-Kanada, Aleksandra, Stojanović, Marijana M., Lukić, Ivana, Marinković, Emilija, Kovačević, Ana, Miljković, Radmila, Tobias, Joshua, Schabussova, Irma, Zlatović, Mario, Barisani-Asenbauer, Talin, Wiedermann, Ursula, and Inic-Kanada, Aleksandra

Abstract

Vaccines can have heterologous effects on the immune system, i.e., effects other than triggering an immune response against the disease targeted by the vaccine. We investigated whether monoclonal antibodies (mAbs) specific for tetanus could cross-react with Chlamydia and confer heterologous protection against chlamydial infection. The capability of two tetanus-specific mAbs, namely mAb26 and mAb51, to prevent chlamydial infection has been assessed: (i) in vitro, by performing a neutralization assay using human conjunctival epithelial (HCjE) cells infected with Chlamydia trachomatis serovar B, and (ii) in vivo, by using a guinea pig model of Chlamydiacaviae-induced inclusion conjunctivitis. The mAb26 has been superior in comparison with mAb51 in the prevention of chlamydial infection in HCjE cells. The mAb26 has conferred ≈40% inhibition of the infection, compared to less than 5% inhibition in the presence of the mAb51. In vivo, mAb26 significantly diminished ocular pathology intensity in guinea pigs infected with C. caviae compared to either the mAb51-treated or sham-treated guinea pigs. Our data provide insights that tetanus immunization generates antibodies which induce heterologous chlamydial immunity and promote protection beyond the intended target pathogen.

Published
2020

34. The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis

Author

Agrawal, Rupesh, primary, Betzler, Bjorn Kaijun, additional, Testi, Ilaria, additional, Mahajan, Sarakshi, additional, Agarwal, Aniruddha, additional, Gunasekeran, Dinesh Visva, additional, Raje, Dhananjay, additional, Aggarwal, Kanika, additional, Murthy, Somasheila I, additional, Westcott, Mark, additional, Chee, Soon-Phaik, additional, McCluskey, Peter, additional, Ho, Su Ling, additional, Teoh, Stephen, additional, Cimino, Luca, additional, Biswas, Jyotirmay, additional, Narain, Shishir, additional, Agarwal, Manisha, additional, Mahendradas, Padmamalini, additional, Khairallah, Moncef, additional, Jones, Nicholas, additional, Tugal-Tutkun, Ilknur, additional, Babu, Kalpana, additional, Basu, Soumayava, additional, Carreño, Ester, additional, Lee, Richard, additional, Al-Dhibi, Hassan, additional, Bodaghi, Bahram, additional, Invernizzi, Alessandro, additional, Goldstein, Debra A, additional, Barisani-Asenbauer, Talin, additional, González-López, Julio J, additional, Androudi, Sofia, additional, Bansal, Reema, additional, Moharana, Bruttendu, additional, Esposti, Simona Degli, additional, Tasiopoulou, Anastasia, additional, Nadarajah, Sengal, additional, Agarwal, Mamta, additional, Abraham, Sharanaya, additional, Vala, Ruchi, additional, Singh, Ramandeep, additional, Sharma, Aman, additional, Sharma, Kusum, additional, Zierhut, Manfred, additional, Kon, Onn Min, additional, Cunningham, Emmett T, additional, Kempen, John H, additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, and Gupta, Vishali, additional

Published
2020
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35. The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population

Author

Testi, Ilaria, primary, Agrawal, Rupesh, additional, Mahajan, Sarakshi, additional, Agarwal, Aniruddha, additional, Gunasekeran, Dinesh Visva, additional, Raje, Dhananjay, additional, Aggarwal, Kanika, additional, Murthy, Somasheila I., additional, Westcott, Mark, additional, Chee, Soon-Phaik, additional, Mccluskey, Peter, additional, Ho, Su Ling, additional, Teoh, Stephen, additional, Cimino, Luca, additional, Biswas, Jyotirmay, additional, Narain, Shishir, additional, Agarwal, Manisha, additional, Mahendradas, Padmamalini, additional, Khairallah, Moncef, additional, Jones, Nicholas, additional, Tugal-Tutkun, Ilknur, additional, Babu, Kalpana, additional, Basu, Soumayava, additional, Carreño, Ester, additional, Lee, Richard, additional, Al-Dhibi, Hassan, additional, Bodaghi, Bahram, additional, Invernizzi, Alessandro, additional, Goldstein, Debra A., additional, Herbort, Carl P., additional, Barisani-Asenbauer, Talin, additional, González-López, Julio J, additional, Androudi, Sofia, additional, Bansal, Reema, additional, Moharana, Bruttendu, additional, Esposti, Simona Degli, additional, Tasiopoulou, Anastasia, additional, Nadarajah, Sengal, additional, Agarwal, Mamta, additional, Abraham, Sharanaya, additional, Vala, Ruchi, additional, Singh, Ramandeep, additional, Sharma, Aman, additional, Sharma, Kusum, additional, Zierhut, Manfred, additional, Kon, Onn Min, additional, Cunningham, Emmett T., additional, Kempen, John H., additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, and Gupta, Vishali, additional

Published
2020
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36. DNA methylation of miR-200 clusters promotes epithelial to mesenchymal transition in human conjunctival epithelial cells

Author

Rajić, Jovana, primary, Dinić, Svetlana, additional, Uskoković, Aleksandra, additional, Arambašić Jovanović, Jelena, additional, Tolić, Anja, additional, Đorđević, Marija, additional, Đorđević, Miloš, additional, Poznanović, Goran, additional, Mihailović, Mirjana, additional, Inic-Kanada, Aleksandra, additional, Barisani-Asenbauer, Talin, additional, Grdović, Nevena, additional, and Vidaković, Melita, additional

Published
2020
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37. Visual Morbidity in Ocular Tuberculosis – Collaborative Ocular Tuberculosis Study (COTS)-1: Report #6

Author

Agrawal, Rupesh, primary, Gunasekeran, Dinesh Visva, additional, Agarwal, Aniruddha, additional, Testi, Ilaria, additional, Carreño, Ester, additional, Westcott, Mark, additional, Mahajan, Sarakshi, additional, Raje, Dhananjay, additional, Aggarwal, Kanika, additional, Murthy, Somasheila I, additional, Chee, Soon-Phaik, additional, Mccluskey, Peter, additional, Ho, Su Ling, additional, Teoh, Stephen, additional, Cimino, Luca, additional, Biswas, Jyotirmay, additional, Narain, Shishir, additional, Agarwal, Manisha, additional, Mahendradas, Padmamalini, additional, Khairallah, Moncef, additional, Jones, Nicholas, additional, Tugal-Tutkun, Ilknur, additional, Babu, Kalpana, additional, Basu, Soumayava, additional, Lee, Richard, additional, Al-Dhibi, Hassan, additional, Bodaghi, Bahram, additional, Invernizzi, Alessandro, additional, Goldstein, Debra A., additional, Herbort, Carl P., additional, Barisani-Asenbauer, Talin, additional, González-López, Julio J, additional, Androudi, Sofia, additional, Bansal, Reema, additional, Moharana, Bruttendu, additional, Esposti, Simona Degli, additional, Tasiopoulou, Anastasia, additional, Nadarajah, Sengal, additional, Agarwal, Mamta, additional, Abraham, Sharanaya, additional, Vala, Ruchi, additional, Singh, Ramandeep, additional, Sharma, Aman, additional, Sharma, Kusum, additional, Zierhut, Manfred, additional, Kon, Onn Min, additional, Cunningham, Emmett T., additional, Kempen, John H., additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, and Gupta, Vishali, additional

Published
2020
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38. The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis

Author

Agrawal, Rupesh, primary, Betzler, Bjorn, additional, Testi, Ilaria, additional, Mahajan, Sarakshi, additional, Agarwal, Aniruddha, additional, Gunasekeran, Dinesh Visva, additional, Raje, Dhananjay, additional, Aggarwal, Kanika, additional, Murthy, Somasheila I, additional, Westcott, Mark, additional, Chee, Soon-Phaik, additional, Mccluskey, Peter, additional, Ho, Su Ling, additional, Teoh, Stephen, additional, Cimino, Luca, additional, Biswas, Jyotirmay, additional, Narain, Shishir, additional, Agarwal, Manisha, additional, Mahendradas, Padmamalini, additional, Khairallah, Moncef, additional, Jones, Nicholas, additional, Tugal-Tutkun, Ilknur, additional, Babu, Kalpana, additional, Basu, Soumayava, additional, Carreño, Ester, additional, Lee, Richard, additional, Al-Dhibi, Hassan, additional, Bodaghi, Bahram, additional, Invernizzi, Alessandro, additional, Goldstein, Debra A., additional, Herbort, Carl P., additional, Barisani-Asenbauer, Talin, additional, González-López, Julio J, additional, Androudi, Sofia, additional, Bansal, Reema, additional, Moharana, Bruttendu, additional, Esposti, Simona, additional, Tasiopoulou, Anastasia, additional, Nadarajah, Sengal, additional, Agarwal, Mamta, additional, Abraham, Sharanya, additional, Vala, Ruchi, additional, Singh, Ramandeep, additional, Sharma, Aman, additional, Sharma, Kusum, additional, Zierhut, Manfred, additional, Kon, Onn Min, additional, Cunningham, Emmett T., additional, Kempen, John H., additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, and Gupta, Vishali, additional

Published
2020
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39. Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the “Cure” in Ocular Tuberculosis

Author

Agarwal, Aniruddha, primary, Agrawal, Rupesh, additional, Raje, Dhananjay, additional, Testi, Ilaria, additional, Mahajan, Sarakshi, additional, Gunasekeran, Dinesh Visva, additional, Aggarwal, Kanika, additional, Murthy, Somasheila I., additional, Westcott, Mark, additional, Chee, Soon-Phaik, additional, Mccluskey, Peter, additional, Ho, Su Ling, additional, Teoh, Stephen, additional, Cimino, Luca, additional, Biswas, Jyotirmay, additional, Narain, Shishir, additional, Agarwal, Manisha, additional, Mahendradas, Padmamalini, additional, Khairallah, Moncef, additional, Jones, Nicholas, additional, Tugal-Tutkun, Ilknur, additional, Babu, Kalpana, additional, Basu, Soumayava, additional, Carreño, Ester, additional, Lee, Richard, additional, Al-Dhibi, Hassan, additional, Bodaghi, Bahram, additional, Invernizzi, Alessandro, additional, Goldstein, Debra A., additional, Herbort, Carl P., additional, Barisani-Asenbauer, Talin, additional, González-López, Julio J., additional, Androudi, Sofia, additional, Bansal, Reema, additional, Moharana, Bruttendu, additional, Esposti, Simona Degli, additional, Tasiopoulou, Anastasia, additional, Nadarajah, Sengal, additional, Agarwal, Mamta, additional, Abraham, Sharanya, additional, Vala, Ruchi, additional, Singh, Ramandeep, additional, Sharma, Aman, additional, Sharma, Kusum, additional, Zierhut, Manfred, additional, Kon, Onn Min, additional, Cunningham, Emmett T., additional, Kempen, John H., additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, and Gupta, Vishali, additional

Published
2020
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40. The Collaborative Ocular Tuberculosis Study (COTS) Consensus (CON) Group Meeting Proceedings

Author

Agrawal, Rupesh, primary, Testi, Ilaria, additional, Mahajan, Sarakshi, additional, Yuen, Yew Sen, additional, Agarwal, Aniruddha, additional, Rousselot, Andres, additional, Raje, Dhananjay, additional, Gunasekeran, Dinesh Visva, additional, Kon, Onn Min, additional, Barisani-Asenbauer, Talin, additional, Kempen, John H., additional, Gupta, Amod, additional, Jabs, Douglas A., additional, Smith, Justine R., additional, Bodaghi, Bahram, additional, Zierhut, Manfred, additional, DeSmet, Marc, additional, Cluskey, Peter Mc, additional, Agarwal, Mamta, additional, Agarwal, Manisha, additional, Aggarwal, Kanika, additional, Agrawal, Mukesh, additional, Al-Dhibi, Hassan, additional, Androudi, Sofia, additional, Asyari, Fatma, additional, Balasundaram, Manohar Babu, additional, Murthy, Kalpana Babu, additional, Baglivo, Edoardo, additional, Banker, Alay, additional, Bansal, Reema, additional, Basu, Soumyava, additional, Behera, Digamber, additional, Biswas, Jyotirmay, additional, Carreño, Ester, additional, Caspers, Laure, additional, Chee, Soon Phaik, additional, Chhabra, Romi, additional, Cimino, Luca, additional, del Rio, Luz Elena Concha, additional, Cunningham, Emmett T., additional, Curi, Andrè Luiz Land, additional, Das, Dipankar, additional, Denisova, Ekaterina, additional, Denniston, Alastair K, additional, Errera, Marie-Hélène, additional, Fonollosa, Alejandro, additional, George, Amala, additional, Goldstein, Debra A., additional, Crosier, Yan Guex, additional, Gurbaxani, Avinash, additional, Invernizzi, Alessandro, additional, Isa, Hazlita M., additional, Md. Islam, Shah, additional, Jones, Nicholas, additional, Katoch, Deeksha, additional, Khairallah, Moncef, additional, Khosla, Amit, additional, Kramer, Michal, additional, Kumar, Amitabh, additional, Kumar, Atul, additional, Nora, Rina La Distia, additional, Lee, Richard, additional, Lowder, Careen, additional, Luthra, Saurabh, additional, Mahendradas, Padmamalini, additional, Makhoul, Dorine, additional, Mazumdar, Shahana, additional, Mehta, Salil, additional, Miserocchi, Elisabetta, additional, Mochizuki, Manabu, additional, Mohamed, Oli S., additional, Muccioli, Cristina, additional, Munk, Marion R, additional, Murthy, Somasheila, additional, Narain, Shishir, additional, Nascimento, Heloisa, additional, Neri, Piergiorgio, additional, Nguyen, Myhanh, additional, Okada, Annabelle A., additional, Ozdal, Pinar, additional, Palestine, Alan, additional, Pichi, Francesco, additional, Rathinam, S.R, additional, Schlaen, Ariel, additional, Sehgal, Shobha, additional, Sen, H Nida, additional, Sharma, Aman, additional, Sharma, Kusum, additional, Shoughy, Samir S., additional, Singh, Nirbhai, additional, Singh, Ramandeep, additional, Soheilian, Masoud, additional, Sridharan, Sudharshan, additional, Thorne, Jennifer E., additional, Tappeiner, Christoph, additional, Teoh, Stephen, additional, Tognon, Maria Sofia, additional, Tugal-Tutkun, Ilknur, additional, Tyagi, Mudit, additional, Uy, Harvey, additional, Santos, Daniel Vitor Vasconcelos, additional, Valentincic, Natasa Vidovic, additional, Westcott, Mark, additional, Yanai, Ryoji, additional, Alvarez, Bety Yanez, additional, Zahedur, Rahman, additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, and Gupta, Vishali, additional

Published
2020
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41. Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Author

Testi, Ilaria, primary, Agrawal, Rupesh, additional, Mahajan, Sarakshi, additional, Agarwal, Aniruddha, additional, Gunasekeran, Dinesh Visva, additional, Raje, Dhananjay, additional, Aggarwal, Kanika, additional, Murthy, Somasheila I., additional, Westcott, Mark, additional, Chee, Soon Phaik, additional, McCluskey, Peter, additional, Ho, Su Ling, additional, Teoh, Stephen, additional, Cimino, Luca, additional, Biswas, Jyotirmay, additional, Narain, Shishir, additional, Agarwal, Manisha, additional, Mahendradas, Padmamalini, additional, Khairallah, Moncef, additional, Jones, Nicholas, additional, Tugal-Tutkun, Ilknur, additional, Babu, Kalpana, additional, Basu, Soumayava, additional, Carreño, Ester, additional, Lee, Richard, additional, Al-Dhibi, Hassan, additional, Bodaghi, Bahram, additional, Invernizzi, Alessandro, additional, Goldstein, Debra A., additional, Herbort, Carl P., additional, Barisani-Asenbauer, Talin, additional, González-López, Julio J., additional, Androudi, Sofia, additional, Bansal, Reema, additional, Moharana, Bruttendu, additional, Esposti, Simona Degli, additional, Tasiopoulou, Anastasia, additional, Nadarajah, Sengal, additional, Agarwal, Mamta, additional, Abraham, Sharanya, additional, Vala, Ruchi, additional, Singh, Ramandeep, additional, Sharma, Aman, additional, Sharma, Kusum, additional, Zierhut, Manfred, additional, Rousselot, Andres, additional, Grant, Robert, additional, Kon, Onn Min, additional, Cunningham, Emmett T., additional, Kempen, John, additional, Nguyen, Quan Dong, additional, Pavesio, Carlos, additional, and Gupta, Vishali, additional

Published
2019
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45. Linguatula serrata tongue worm in human eye, Austria

Author

Koehsler, Martina, Walochnik, Julia, Georgopoulos, Michael, Pruente, Christian, Boeckeler, Wolfgang, Auer, Herbert, and Barisani-Asenbauer, Talin

Subjects
Parasitic diseases -- Causes of -- Distribution -- Prevention -- Research, Company distribution practices, Health
Abstract

The species Linguatula serrata belongs to the Pentastomida, a still-enigmatic group of worm-like, bloodsucking parasites that inhabit the upper respiratory tract of terrestrial, carnivorous vertebrates, mostly reptiles and birds; L. [...]

Published
2011
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47. Uveitis- a rare disease often associated with systemic diseases and infections- a systematic review of 2619 patients

Author

Barisani-Asenbauer Talin, Maca Saskia M, Mejdoubi Lamiss, Emminger Wolfgang, Machold Klaus, and Auer Herbert

Subjects
Uveitis, Etiology, Systemic associations, Arthritis, Infections, Medicine
Abstract

Abstract Background Uveitis is an autoimmune disease of the eye that refers to any of a number of intraocular inflammatory conditions. Because it is a rare disease, uveitis is often overlooked, and the possible associations between uveitis and extra-ocular disease manifestations are not well known. The aim of this study was to characterize uveitis in a large sample of patients and to evaluate the relationship between uveitis and systemic diseases. Methods The present study is a cross-sectional study of a cohort of patients with uveitis. Records from consecutive uveitis patients who were seen by the Uveitis Service in the Department of Ophthalmology at the Medical University of Vienna between 1995 and 2009 were selected from the clinical databases. The cases were classified according to the Standardization of Uveitis Nomenclature Study Group criteria for Uveitis. Results Data were available for 2619 patients, of whom 59.9% suffered from anterior, 14.8% from intermediate, 18.3% from posterior and 7.0% from panuveitis. 37.2% of all cases showed an association between uveitis and extra-organ diseases; diseases with primarily arthritic manifestations were seen in 10.1% of all cases, non-infectious systemic diseases (i.e., Behçet´s disease, sarcoidosis or multiple sclerosis) in 8.4% and infectious uveitis in 18.7%. 49.4% of subjects suffering from anterior uveitis tested positively for the HLA-B27 antigen. In posterior uveitis cases 29% were caused by ocular toxoplasmosis and 17.7% by multifocal choroiditis. Conclusion Ophthalmologists, rheumatologists, infectiologists, neurologists and general practitioners should be familiar with the differential diagnosis of uveitis. A better interdisciplinary approach could help in tailoring of the work-up, earlier diagnosis of co-existing diseases and management of uveitis patients.

Published
2012
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48. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative

Author

Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, and Fortin, Eric

Subjects
Ophthalmology
Abstract

Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. Clinical Relevance: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. Methods: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review. A total of 44 globally representative group members met in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence. Results: In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agents; what data to collect before treatment; when to modify or withdraw treatment; how to select agents based on individual efficacy and safety profiles; and evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed. Conclusions: Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents.

Published
2018

50. Detection of Chlamydiaceae and Chlamydia-like organisms on the ocular surface of children and adults from a trachoma-endemic region

Author

Ghasemian, Ehsan; https://orcid.org/0000-0003-1019-6572, Inic-Kanada, Aleksandra; https://orcid.org/0000-0001-7854-3812, Collingro, Astrid; https://orcid.org/0000-0002-4100-832X, Tagini, Florian, Stein, Elisabeth, Alchalabi, Hadeel, Schuerer, Nadine, Keše, Darja, Babiker, Balgesa Elkheir, Borel, Nicole; https://orcid.org/0000-0002-1556-9262, Greub, Gilbert; https://orcid.org/0000-0001-9529-3317, Barisani-Asenbauer, Talin, Ghasemian, Ehsan; https://orcid.org/0000-0003-1019-6572, Inic-Kanada, Aleksandra; https://orcid.org/0000-0001-7854-3812, Collingro, Astrid; https://orcid.org/0000-0002-4100-832X, Tagini, Florian, Stein, Elisabeth, Alchalabi, Hadeel, Schuerer, Nadine, Keše, Darja, Babiker, Balgesa Elkheir, Borel, Nicole; https://orcid.org/0000-0002-1556-9262, Greub, Gilbert; https://orcid.org/0000-0001-9529-3317, and Barisani-Asenbauer, Talin

Abstract

Trachoma, the leading infectious cause of blindness, is caused by Chlamydia trachomatis (Ct), a bacterium of the phylum Chlamydiae. Recent investigations revealed the existence of additional families within the phylum Chlamydiae, also termed Chlamydia-like organisms (CLOs). In this study, the frequency of Ct and CLOs was examined in the eyes of healthy Sudanese (control) participants and those with trachoma (case). We tested 96 children (54 cases and 42 controls) and 93 adults (51 cases and 42 controls) using broad-range Chlamydiae and Ct-specific (omcB) real-time PCR. Samples positive by broad-range Chlamydiae testing were subjected to DNA sequencing. Overall Chlamydiae prevalence was 36%. Sequences corresponded to unclassified and classified Chlamydiae. Ct infection rate was significantly higher in children (31.5%) compared to adults (0%) with trachoma (p < 0.0001). In general, 21.5% of adults and 4.2% of children tested positive for CLOs (p = 0.0003). Our findings are consistent with previous investigations describing the central role of Ct in trachoma among children. This is the first study examining human eyes for the presence of CLOs. We found an age-dependent distribution of CLO DNA in human eyes with significantly higher positivity in adults. Further studies are needed to understand the impact of CLOs in trachoma pathogenicity and/or protection.

Published
2018

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