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2. Leishmania genetic exchange is mediated by IgM natural antibodies

Author

Serafim, Tiago D., Iniguez, Eva, Barletta, Ana Beatriz F., Cecilio, Pedro, Doehl, Johannes S. P., Short, Mara, Lack, Justin, Nair, Vinod, Disotuar, Maria, Wilson, Timothy, Coutinho-Abreu, Iliano V., Meneses, Claudio, Andersen, John, Alves E Silva, Thiago Luiz, Oliveira, Fabiano, Vega-Rodriguez, Joel, Barillas-Mury, Carolina, Ribeiro, José M. C., Beverley, Stephen M., Kamhawi, Shaden, and Valenzuela, Jesus G.

Published
2023
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8. Human norovirus targets enteroendocrine epithelial cells in the small intestine

Author

Green, Kim Y., Kaufman, Stuart S., Nagata, Bianca M., Chaimongkol, Natthawan, Kim, Daniel Y., Levenson, Eric A., Tin, Christine M., Yardley, Allison Behrle, Johnson, Jordan A., Barletta, Ana Beatriz F., Khan, Khalid M., Yazigi, Nada A., Subramanian, Sukanya, Moturi, Sangeetha R., Fishbein, Thomas M., Moore, Ian N., and Sosnovtsev, Stanislav V.

Published
2020
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9. The Aedes aegypti peritrophic matrix controls arbovirus vector competence through HPx1, a heme–induced peroxidase

Author

Talyuli, Octavio A. C., primary, Oliveira, Jose Henrique M., additional, Bottino-Rojas, Vanessa, additional, Silveira, Gilbert O., additional, Alvarenga, Patricia H., additional, Barletta, Ana Beatriz F., additional, Kantor, Asher M., additional, Paiva-Silva, Gabriela O., additional, Barillas-Mury, Carolina, additional, and Oliveira, Pedro L., additional

Published
2023
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13. List of Contributors

Author

Asgari, Sassan, primary, Barillas-Mury, Carolina V., additional, Barletta, Ana Beatriz F., additional, Blair, Carol D., additional, Caragata, Eric P., additional, Christophides, George K., additional, Costero-Saint Denis, Adriana, additional, Foy, Brian D., additional, Gendrin, Mathilde, additional, Jacobs-Lorena, Marcelo, additional, Leitner, Wolfgang W., additional, Luckhart, Shirley, additional, Meyers, Jacob I., additional, Michel, Kristin, additional, Moreira, Luciano A., additional, Olson, Ken E., additional, Pan, Xiaoling, additional, Pietri, Jose E., additional, Ramirez, Jose L., additional, Rhodes, Victoria L.M., additional, Riehle, Michael A., additional, Rodgers, Faye H., additional, Strand, Michael R., additional, Thiem, Suzanne, additional, Vigneron, Aurélien, additional, Wali, Tonu M., additional, Wang, Sibao, additional, Weiss, Brian L., additional, and Xi, Zhiyong, additional

Published
2017
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15. Genetic exchange in Leishmania is facilitated by IgM natural antibodies

Author

Serafim, Tiago D., primary, Iniguez, Eva, additional, Barletta, Ana Beatriz F., additional, Doehl, Johannes S.P., additional, Short, Mara, additional, Lack, Justin, additional, Cecilio, Pedro, additional, Nair, Vinod, additional, Disotuar, Maria, additional, Wilson, Timothy, additional, Coutinho-Abreu, Iliano V., additional, Oliveira, Fabiano, additional, Meneses, Claudio, additional, Barillas-Mury, Carolina, additional, Andersen, John, additional, Ribeiro, José M.C., additional, Beverley, Stephen M., additional, Kamhawi, Shaden, additional, and G.Valenzuela, Jesus, additional

Published
2022
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16. Corrigendum to: Morphological Characterization of the Antennal Sensilla of the Afrotropical Sand Fly, Phlebotomus duboscqi (Diptera: Psychodidae)

Author

Bahia, Ana Cristina, primary, Barletta, Ana Beatriz F, additional, Pinto, Luciana Conceição, additional, Orfanó, Alessandra S, additional, Nacif-Pimenta, Rafael, additional, Volfova, Vera, additional, Volf, Petr, additional, Secundino, Nágila Francinete Costa, additional, de Freitas Fernandes, Fernando, additional, and Pimenta, Paulo Filemon P, additional

Published
2021
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17. Leishmaniagenetic exchange is mediated by IgM natural antibodies

Author

Serafim, Tiago D., Iniguez, Eva, Barletta, Ana Beatriz F., Cecilio, Pedro, Doehl, Johannes S. P., Short, Mara, Lack, Justin, Nair, Vinod, Disotuar, Maria, Wilson, Timothy, Coutinho-Abreu, Iliano V., Meneses, Claudio, Andersen, John, Alves E Silva, Thiago Luiz, Oliveira, Fabiano, Vega-Rodriguez, Joel, Barillas-Mury, Carolina, Ribeiro, José M. C., Beverley, Stephen M., Kamhawi, Shaden, and Valenzuela, Jesus G.

Abstract

Host factors that mediate Leishmaniagenetic exchange are not well defined. Here we demonstrate that natural IgM (IgMn)1–4antibodies mediate parasite genetic exchange by inducing the transient formation of a spherical parasite clump that promotes parasite fusion and hybrid formation. We establish that IgMn from Leishmania-free animals binds to the surface of Leishmaniaparasites to induce significant changes in the expression of parasite transcripts and proteins. Leishmaniabinding to IgMn is partially lost after glycosidase treatment, although parasite surface phosphoglycans, including lipophosphoglycan, are not required for IgMn-induced parasite clumping. Notably, the transient formation of parasite clumps is essential for Leishmaniahybridization in vitro. In vivo, we observed a 12-fold increase in hybrid formation in sand flies provided a second blood meal containing IgMn compared with controls. Furthermore, the generation of recombinant progeny from mating hybrids and parental lines were only observed in sand flies provided with IgMn. Both in vitro and in vivo IgM-induced Leishmaniacrosses resulted in full genome hybrids that show equal patterns of biparental contribution. Leishmaniaco-option of a host natural antibody to facilitate mating in the insect vector establishes a new paradigm of parasite–host–vector interdependence that contributes to parasite diversity and fitness by promoting genetic exchange.

Published
2023
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18. Mosquito cellular immunity at single-cell resolution

Author

Raddi, Gianmarco, Barletta, Ana Beatriz F., Efremova, Mirjana, Ramirez, Jose Luis, Cantera, Rafael, Teichmann, Sarah A., Barillas-Mury, Carolina, Billker, Oliver, Raddi, Gianmarco, Barletta, Ana Beatriz F., Efremova, Mirjana, Ramirez, Jose Luis, Cantera, Rafael, Teichmann, Sarah A., Barillas-Mury, Carolina, and Billker, Oliver

Abstract

Hemocytes limit the capacity of mosquitoes to transmit human pathogens. Here we profile the transcriptomes of 8506 hemocytes of Anopheles gambiae and Aedes aegypti mosquito vectors. Our data reveal the functional diversity of hemocytes, with different subtypes of granulocytes expressing distinct and evolutionarily conserved subsets of effector genes. A previously unidentified cell type in An. gambiae, which we term "megacyte," is defined by a specific transmembrane protein marker (TM7318) and high expression of lipopolysaccharide-induced tumor necrosis factor-a transcription factor 3 (LL3). Knockdown experiments indicate that LL3 mediates hemocyte differentiation during immune priming. We identify and validate two main hemocyte lineages and find evidence of proliferating granulocyte populations. This atlas of medically relevant invertebrate immune cells at single-cell resolution identifies cellular events that underpin mosquito immunity to malaria infection.

Published
2020
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19. Morphological Characterization of the Antennal Sensilla of the Afrotropical Sand Fly, Phlebotomus duboscqi (Diptera: Psychodidae)

Author

Bahia, Ana Cristina, primary, Barletta, Ana Beatriz F, additional, Pinto, Luciana Conceição, additional, Orfanó, Alessandra S, additional, Nacif-Pimenta, Rafael, additional, Volfova, Vera, additional, Volf, Petr, additional, Secundino, Nágila Francinete Costa, additional, de Freitas Fernandes, Fernando, additional, and Pimenta, Paulo Filemon P, additional

Published
2020
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20. Prostaglandins regulate humoral immune responses in Aedes aegypti

Author

Barletta, Ana Beatriz Ferreira, primary, Alves e Silva, Thiago Luiz, additional, Talyuli, Octavio A. C., additional, Luna-Gomes, Tatiana, additional, Sim, Shuzhen, additional, Angleró-Rodríguez, Yesseinia, additional, Dimopoulos, George, additional, Bandeira-Melo, Christianne, additional, and Sorgine, Marcos H. Ferreira, additional

Published
2020
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22. Mosquito cellular immunity at single-cell resolution

Author

Raddi, Gianmarco, primary, Barletta, Ana Beatriz F., additional, Efremova, Mirjana, additional, Ramirez, Jose Luis, additional, Cantera, Rafael, additional, Teichmann, Sarah A., additional, Barillas-Mury, Carolina, additional, and Billker, Oliver, additional

Published
2020
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23. Ultrastructure of the Antennae and Sensilla of Nyssomyia intermedia (Diptera: Psychodidae), Vector of American Cutaneous Leishmaniasis

Author

Fernandes, Fernando de Freitas, primary, Barletta, Ana Beatriz F, additional, Orfanó, Alessandra S, additional, Pinto, Luciana C, additional, Nacif-Pimenta, Rafael, additional, Miranda, Jose Carlos, additional, Secundino, Nágila F C, additional, Bahia, Ana Cristina, additional, and Pimenta, Paulo F P, additional

Published
2020
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25. A mosquito juvenile hormone binding protein (mJHBP) regulates the activation of innate immune defenses and hemocyte development

Author

Kim, Il Hwan, primary, Castillo, Julio César, additional, Aryan, Azadeh, additional, Martin-Martin, Inés, additional, Nouzova, Marcela, additional, Noriega, Fernando G., additional, Barletta, Ana Beatriz F., additional, Calvo, Eric, additional, Adelman, Zachary N., additional, Ribeiro, José M. C., additional, and Andersen, John F., additional

Published
2020
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27. Morphological Characterization of the Antennal Sensilla of the Afrotropical Sand Fly, Phlebotomus duboscqi(Diptera: Psychodidae)

Author

Bahia, Ana Cristina, Barletta, Ana Beatriz F, Pinto, Luciana Conceição, Orfanó, Alessandra S, Nacif-Pimenta, Rafael, Volfova, Vera, Volf, Petr, Secundino, Nágila Francinete Costa, de Freitas Fernandes, Fernando, and Pimenta, Paulo Filemon P

Abstract

We investigated by scanning electron microscopy the morphology, distribution, and abundance of antennal sensilla of females Phlebotomus duboscqisand fly, an important vector of zoonotic cutaneous leishmaniasis at Afrotropical region. Thirteen well-differentiated sensilla were identified, among six types of cuticular sensilla. The probable function of these sensillary types is discussed in relation to their external structure and distribution. Five sensillary types were classified as olfactory sensilla, as they have specific morphological characters of sensilla with this function. Number and distribution of sensilla significantly differed between antennal segments. The results of the present work, besides corroborating in the expansion of the morphological and ultrastructural knowledge of P. duboscqi, can foment future electrophysiological studies for the development of volatile semiochemicals, to be used as attractants in traps for monitoring and selective vector control of this sand fly.

Published
2021
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28. Ultrastructure of the Antennae and Sensilla of Nyssomyia intermedia(Diptera: Psychodidae), Vector of American Cutaneous Leishmaniasis

Author

Fernandes, Fernando de Freitas, Barletta, Ana Beatriz F, Orfanó, Alessandra S, Pinto, Luciana C, Nacif-Pimenta, Rafael, Miranda, Jose Carlos, Secundino, Nágila F C, Bahia, Ana Cristina, and Pimenta, Paulo F P

Abstract

The antennal sensilla and the antenna of females Nyssomyia intermedia, one of the main vectors of American cutaneous leishmaniasis, were studied by scanning electron microscopy. The main goal was to characterize the quantity, typology, and topography of the sensilla with particular attention to the olfactory types. The insects were captured in the city of Corte de Pedra, State of Bahia, Brazil, by CDC-type light traps and raised in a laboratory as a new colony. Fourteen well-differentiated sensilla were identified, among six cuticular types: trichoidea, campaniformia, squamiformia, basiconica, chaetica, and coeloconica. Of these, six sensilla were classified as olfactory sensilla due to their specific morphological features. Smaller noninnervated pilosities of microtrichiaetype were also evidenced by covering all antennal segments. The antennal segments differ in shapes and sizes, and the amount and distribution of types and subtypes of sensilla. This study may foment future taxonomic and phylogenetic analysis for a better evolutionary understanding of the sand flies. Besides, it may assist the targeting of future electrophysiological studies by Single Sensillum Recording, and aim to develop alternative measures of monitoring and control of this vector.

Published
2020
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35. Mosquito midgut stem cell cellular defense response limits Plasmodium parasite infection.

Author

Barletta AF, Smith JC, Burkart E, Bondarenko S, Sharakhov I, Criscione F, O'Brochta D, and Barillas-Mury C

Abstract

A novel cellular response of midgut progenitors (stem cells and enteroblasts) to Plasmodium berghei infection was investigated in Anopheles stephensi. The presence of developing oocysts triggers proliferation of midgut progenitors that is modulated by the Jak/STAT pathway, and proportional to the number of oocysts on individual midguts. The percentage of parasites in direct contact with enteroblasts increases over time, as progenitors proliferate. Enhancing proliferation of progenitors significantly decreases oocyst numbers, while limiting proliferation increases oocyst survival. Live imaging revealed that enteroblasts interact directly with oocysts and eliminate them. Midgut progenitors sense the presence of Plasmodium oocysts and mount a cellular defense response that involves extensive proliferation and tissue remodeling, followed by oocysts lysis and phagocytosis of parasite remnants by enteroblasts., Competing Interests: Competing interests The authors declare no competing financial interests.

Published
2023
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37. Morphological Characterization of the Antennal Sensilla of the Afrotropical Sand Fly, Phlebotomus duboscqi (Diptera: Psychodidae).

Author

Bahia AC, Barletta ABF, Pinto LC, Orfanó AS, Nacif-Pimenta R, Volfova V, Petr V, Secundino NFC, de Freitas Fernandes F, and Pimenta PFP

Subjects
Animals, Female, Phlebotomus physiology, Sensilla physiology, Phlebotomus ultrastructure, Sensilla ultrastructure
Abstract

We investigated by scanning electron microscopy the morphology, distribution, and abundance of antennal sensilla of females Phlebotomus duboscqi sand fly, an important vector of zoonotic cutaneous leishmaniasis at Afrotropical region. Thirteen well-differentiated sensilla were identified, among six types of cuticular sensilla. The probable function of these sensillary types is discussed in relation to their external structure and distribution. Five sensillary types were classified as olfactory sensilla, as they have specific morphological characters of sensilla with this function. Number and distribution of sensilla significantly differed between antennal segments. The results of the present work, besides corroborating in the expansion of the morphological and ultrastructural knowledge of P. duboscqi, can foment future electrophysiological studies for the development of volatile semiochemicals, to be used as attractants in traps for monitoring and selective vector control of this sand fly., (© The Author(s) 2020. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2021
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