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11. Effectiveness of the Unified Protocol for transdiagnostic treatment of emotional disorders in group format in Spain: Results from a randomized controlled trial with 6-months follow-up.

Author

Osma, J., Peris-Baquero, O., Suso-Ribera, C., Farchione, T. J., and Barlow, D. H.

Subjects
RANDOMIZED controlled trials, COGNITIVE therapy, MEDICAL protocols, MENTAL depression, MENTAL health
Abstract

The present study aims to investigate the effectiveness of the Unified Protocol (UP), a transdiagnostic treatment of emotional disorders (EDs), when applied in a group format in the public mental health system in Spain. 488 participants with a primary diagnosis of ED were randomized to the UP group or to the treatment as usual (TAU; individual, disorder-specific cognitive behavioral therapy). Personality, depression and anxiety symptoms, affect, and quality of life were assessed at pre-treatment, 3 months after treatment onset (coinciding with the end of the UP treatment), and 6 and 9 months after treatment onset (follow-ups). The moderating effect of the treatment condition and the number of sessions received in the evolution of study outcomes was investigated with a linear mixed model analysis. A significant improvement in outcomes occurred in both conditions, except for extraversion in the TAU. Improvements in depression, anxiety and quality of life were larger in the UP condition. After the treatment, improvements were maintained at follow-ups in all study outcomes. An interaction between Time*Condition*Sessions was found for depression. The results add to the existing evidence on the effectiveness of the UP and may be important for implementation purposes in the Spanish or other similar public mental health systems. Trial registration number NCT03064477 (March 10, 2017). [ABSTRACT FROM AUTHOR]

Published
2022
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23. Ulipristal acetate versus leuprolide acetate for uterine fibroids

Author

Donnez J., Tomaszewski J., Vaszquez F., Bouchard P., Lemieszczuk B., Barò F., Nouri K., Selvaggi L., Sodowski K., Bestel E., Terrill P., Osterloh I., Loumaye E., Barlow D. H., Barri P. N., Bergeron C., Bornstein J., Caraco Y., Carmona F., Caruso A., Diedrich K., Donnez O., Fauser B. C., Ferenczy A., Gilabert J., Giuliani A., Glezerman M., Goettker Schnetmann W., Hillemanns P., Huber J., Jimenez J. S., Kay R., Kiesel L., Kotarski J., Layani L., Mannering M., Marshall J., Martinez S., McPherson K., Melis G. B., Milani R., Morris E., Nisolle M., Palacios S., Parrilla J. J., Paul N. W., Pawlaczyk A., Pellicer A., Perino A., Vazquez F., Williams A. R., de Ziegler D., NAPPI, CARMINE, Donnez, J., Tomaszewski, J., Vaszquez, F., Bouchard, P., Lemieszczuk, B., Barò, F., Nouri, K., Selvaggi, L., Sodowski, K., Bestel, E., Terrill, P., Osterloh, I., Loumaye, E., Barlow, D. H., Barri, P. N., Bergeron, C., Bornstein, J., Caraco, Y., Carmona, F., Caruso, A., Diedrich, K., Donnez, O., Fauser, B. C., Ferenczy, A., Gilabert, J., Giuliani, A., Glezerman, M., Goettker Schnetmann, W., Hillemanns, P., Huber, J., Jimenez, J. S., Kay, R., Kiesel, L., Kotarski, J., Layani, L., Mannering, M., Marshall, J., Martinez, S., Mcpherson, K., Melis, G. B., Milani, R., Morris, E., Nappi, Carmine, Nisolle, M., Palacios, S., Parrilla, J. J., Paul, N. W., Pawlaczyk, A., Pellicer, A., Perino, A., Vazquez, F., Williams, A. R., and de Ziegler, D.

Subjects
myoma, fibroid, ulipristal
Published
2012

24. The community prevalence of chronic pelvic pain in women and associated illness behaviour

Author

Zondervan, K. T., Yudkin, P. L., Vessey, M. P., Jenkinson, C. P., Martin Dawes, Barlow, D. H., and Kennedy, S. H.

Subjects
Research Article
Abstract

BACKGROUND: Chronic pelvic pain has often been described as a major women's health issue, but no information exists on the extent of the problem in the United Kingdom. AIM: To investigate the community prevalence of chronic pelvic pain and its effect on the lives of consulting and non-consulting women. DESIGN OF STUDY: Postal questionnaire survey. SETTING: Women aged 18 to 49 (n = 3916) randomly selected from the Oxfordshire Health Authority Register. METHOD: The questionnaire response rate (adjusted for non-deliveries) was 74% (2304/3106). Chronic pelvic pain was defined as recurrent or constant pelvic pain of at least six months' duration, unrelated to periods, intercourse, or pregnancy. Case subgroups comprised recent consulters, past consulters, and non-consulters. Women who reported dysmenorrhoea alone formed a comparison group. RESULTS: The three-month prevalence of chronic pelvic pain was 24.0% (95% CI = 22.1% to 25.8%). One-third of women reported pain that started more than five years ago. Recent consulters (32% of cases) were most affected by their symptoms in terms of pain severity, use of health care, physical and mental health scores, sleep quality, and pain-related absence from work. Non-consulters (41% of cases) did not differ from women with dysmenorrhoea in terms of symptom-related impairment. Irrespective of consulting behaviour, a high rate of symptom-related anxiety was found in women with chronic pelvic pain (31%) compared with women with dysmenorrhoea (7%). CONCLUSIONS: This study showed a high community prevalence of chronic pelvic pain in women of reproductive age. Cases varied substantially in the degree to which they were affected by their symptoms. The high symptom-related anxiety in these women emphasises the need for more information about chronic pelvic pain and its possible causes.

Published
2001

30. Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26

Author

Treloar, S. A., Wicks, J., Nyholt, D. R., Montgomery, G. W., Bahlo, M., Smith, V., Dawson, G., Mackay, I. J., Weeks, D. E., Bennett, S. T., Carey, A., Ewen-White, K. R., Duffy, D. L., O'Connor D, T., Barlow, D. H., Martin, N. G., Kennedy, S. H., Treloar, S. A., Wicks, J., Nyholt, D. R., Montgomery, G. W., Bahlo, M., Smith, V., Dawson, G., Mackay, I. J., Weeks, D. E., Bennett, S. T., Carey, A., Ewen-White, K. R., Duffy, D. L., O'Connor D, T., Barlow, D. H., Martin, N. G., and Kennedy, S. H.

Abstract

Free to read on publisher website Endometriosis is a common gynecological disease that affects up to 10% of women in their reproductive years. It causes pelvic pain, severe dysmenorrhea, and subfertility. The disease is defined as the presence of tissue resembling endometrium in sites outside the uterus. Its cause remains uncertain despite >50 years of hypothesis-driven research, and thus the therapeutic options are limited. Disease predisposition is inherited as a complex genetic trait, which provides an alternative route to understanding the disease. We seek to identify susceptibility loci, using a positional-cloning approach that starts with linkage analysis to identify genomic regions likely to harbor these genes. We conducted a linkage study of 1,176 families (931 from an Australian group and 245 from a U.K. group), each with at least two members--mainly affected sister pairs--with surgically diagnosed disease. We have identified a region of significant linkage on chromosome 10q26 (maximum LOD score [MLS] of 3.09; genomewide P = .047) and another region of suggestive linkage on chromosome 20p13 (MLS = 2.09). Minor peaks (with MLS > 1.0) were found on chromosomes 2, 6, 7, 8, 12, 14, 15, and 17. This is the first report of linkage to a major locus for endometriosis. The findings will facilitate discovery of novel positional genetic variants that influence the risk of developing this debilitating disease. Greater understanding of the aberrant cellular and molecular mechanisms involved in the etiology and pathophysiology of endometriosis should lead to better diagnostic methods and targeted treatments.

Published
2005

43. Endometriosis 1991: a discussion document.

Author

UCL, Audebert, A, Bäckström, T, Barlow, D H, Benagiano, G, Brosens, I., Bühler, K, Donnez, Jacques, Evers, J L, Pellicer, A., Mettler, L, UCL, Audebert, A, Bäckström, T, Barlow, D H, Benagiano, G, Brosens, I., Bühler, K, Donnez, Jacques, Evers, J L, Pellicer, A., and Mettler, L

Published
1992

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